Information on EC 1.8.1.6 - cystine reductase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.8.1.6
-
RECOMMENDED NAME
GeneOntology No.
cystine reductase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2 L-cysteine + NAD+ = L-cystine + NADH + H+
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
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redox reaction
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-
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reduction
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
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cysteine metabolism
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SYSTEMATIC NAME
IUBMB Comments
L-cysteine:NAD+ oxidoreductase
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SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
cystine reductase (NADH)
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-
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cystine reductase (NADH2)
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L-cysteine:NAD+ oxidoreductase
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NADH-dependent cystine reductase
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NADH2:L-cystine oxidoreductase
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reductase, cystine
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-
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CAS REGISTRY NUMBER
COMMENTARY
9029-18-9
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Ajellomyces capsulatus
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-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-cystine + glutathione
L-cysteine + GSSG
show the reaction diagram
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-
-
-
?
NADH + L-cystine
NAD+ + L-cysteine
show the reaction diagram
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-
-
?
NADH + L-cystine
NAD+ + L-cysteine
show the reaction diagram
-
-
-
?
NADH + L-cystine
NAD+ + L-cysteine
show the reaction diagram
-
-
-
?
NADH + L-cystine
NAD+ + L-cysteine
show the reaction diagram
-
-
-
?
NADH + L-cystine
NAD+ + L-cysteine
show the reaction diagram
Ajellomyces capsulatus
-
-
-
?
NADH + L-cystine
?
show the reaction diagram
Ajellomyces capsulatus
-
the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form
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-
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NADH + L-cystine + H+
NAD+ + L-cysteine
show the reaction diagram
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-
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
NADH + L-cystine
?
show the reaction diagram
Ajellomyces capsulatus
-
the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NADH
Ajellomyces capsulatus
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-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
amphotericin
-
100% inhibition at a concentration of 0.032 mg/ml
chlorpromazine
-
100% inhibition at a concentration of 0.032 mg/ml
ketoconazole
-
100% inhibition at a concentration of 0.032 mg/ml
Mepacrine
-
100% inhibition at a concentration of 0.032 mg/ml
metronidazole
-
26% inhibition at a concentration of 0.032 mg/ml
Miconazole
-
100% inhibition at a concentration of 0.032 mg/ml
p-Chloromercuriphenylsulfonic acid
Ajellomyces capsulatus
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strong
Pentamidine
-
58% inhibition at a concentration of 0.032 mg/ml
trifluoroperazine
-
100% inhibition at a concentration of 0.032 mg/ml
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
amphotericin
-
29% enhancement of activity at a concentration of 0.032 mg/ml
Mepacrine
-
56% enhancement of activity at a concentration of 0.032 mg/ml
metronidazole
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4fold stimulation at a concentration of 0.032 mg/ml
Rifampicin
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147% enhancement of activity at a concentration of 0.032 mg/ml
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.11
L-cystine
Ajellomyces capsulatus
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-
0.9
L-cystine
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-
additional information
additional information
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
Ajellomyces capsulatus
-
the enzyme is phase specific it is not present in mycelium appears early in the transition of mycelium to yeast
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni2+ affinity column chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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