Information on EC 1.8.1.6 - cystine reductase

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The enzyme appears in viruses and cellular organisms

top print hide
EC NUMBER
COMMENTARY hide
1.8.1.6
-
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RECOMMENDED NAME
GeneOntology No.
cystine reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 L-cysteine + NAD+ = L-cystine + NADH + H+
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
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-
cysteine metabolism
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-
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SYSTEMATIC NAME
IUBMB Comments
L-cysteine:NAD+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
9029-18-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-cystine + glutathione
L-cysteine + GSSG
show the reaction diagram
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-
-
-
?
NADH + L-cystine
?
show the reaction diagram
-
the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form
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-
-
NADH + L-cystine
NAD+ + L-cysteine
show the reaction diagram
NADH + L-cystine + H+
NAD+ + L-cysteine
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
NADH + L-cystine
?
show the reaction diagram
-
the enzyme may provide reduced sulfhydryl groups involved in the transition of mycelium to yeast form
-
-
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amphotericin
-
100% inhibition at a concentration of 0.032 mg/ml
chlorpromazine
ketoconazole
-
100% inhibition at a concentration of 0.032 mg/ml
Mepacrine
-
100% inhibition at a concentration of 0.032 mg/ml
metronidazole
-
26% inhibition at a concentration of 0.032 mg/ml
miconazole
p-Chloromercuriphenylsulfonic acid
-
strong
Pentamidine
-
58% inhibition at a concentration of 0.032 mg/ml
trifluoroperazine
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amphotericin
-
29% enhancement of activity at a concentration of 0.032 mg/ml
Mepacrine
-
56% enhancement of activity at a concentration of 0.032 mg/ml
metronidazole
-
4fold stimulation at a concentration of 0.032 mg/ml
rifampicin
-
147% enhancement of activity at a concentration of 0.032 mg/ml
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.11 - 0.9
L-cystine
additional information
additional information
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-
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
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the enzyme is phase specific it is not present in mycelium appears early in the transition of mycelium to yeast
Manually annotated by BRENDA team
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni2+ affinity column chromatography
-
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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LINKS TO OTHER DATABASES (specific for EC-Number 1.8.1.6)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)