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Information on EC 1.7.1.7 - GMP reductase and Organism(s) Rattus norvegicus and UniProt Accession Q9Z244

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Rattus norvegicus
UNIPROT: Q9Z244 not found.
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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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IMP
+
NH3
+
NADP+
=
GMP
+
NADPH
+
H+
+
+
=
+
+
Synonyms
gmp reductase, gmpr2, guanosine monophosphate reductase, guanosine 5'-monophosphate reductase, tbgmpr, guanosine-5'-monophosphate reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Guanosine 5'-monophosphate oxidoreductase
-
-
-
-
guanosine 5'-monophosphate reductase
-
-
-
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guanosine monophosphate reductase
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-
-
-
guanylate reductase
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-
-
-
NADPH:GMP oxidoreductase (deaminating)
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-
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reductase, guanylate
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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-
-
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oxidation
-
-
-
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reduction
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-
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reductive deamination
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-
-
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
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CAS REGISTRY NUMBER
COMMENTARY hide
9029-32-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
NADPH + guanosine 5'-phosphate
NADP+ + inosine 5'-phosphate + NH3
show the reaction diagram
enzyme may play a role in brown fat response
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
mRNA increases 30fold in brown adipose tissue within 6 h of cold exposure
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
5fold lower than in unstimulated brown adipose tisssue, no increase during cold-stress
Manually annotated by BRENDA team
weak expression in cold-stimulated animals
Manually annotated by BRENDA team
5fold lower than in unstimulated brown adipose tisssue, no increase during cold-stress
Manually annotated by BRENDA team
additional information
not expressed in testis, lung, liver or spleen
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GMPR1_RAT
345
0
37488
Swiss-Prot
other Location (Reliability: 4)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Salvatore, D.; Bartha, T.; Larsen, P.R.
The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure
J. Biol. Chem.
273
31092-31096
1998
Rattus norvegicus (Q9Z244)
Manually annotated by BRENDA team