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Disease on EC 1.6.99.1 - NADPH dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
46, XX Disorders of Sex Development
Immunohistochemical description of nitric oxide synthase isoforms in human clitoris.
Aberrant Crypt Foci
Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor.
Abortion, Habitual
Polymorphisms in NOS3, ACE and PAI-1 genes and risk of spontaneous recurrent miscarriage in the Gaza Strip.
Polymorphisms of the angiotensinogen gene, the endothelial nitric oxide synthase gene, and the interleukin-1beta gene promoter in women with idiopathic recurrent miscarriage.
Abortion, Spontaneous
Adrenomedullin and nitric oxide synthase at the maternal-decidual interface in early spontaneous abortion.
[Association of genetic polymorphisms in endothelial nitric oxide osynthase 3 gene with recurrent early spontaneous abortion]
Acantholysis
Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase.
Acidosis
Effect of pH changes on reactivity of rat mesenteric artery segments at different magnitude of stretch.
Nitric oxide synthase inhibition by L-NAME during repetitive focal cerebral ischemia in rabbits.
Nitric oxide synthase inhibition by L-NAME prevents brain acidosis during focal cerebral ischemia in rabbits.
No effect of metabolic acidosis on nitric oxide production in hypoxic and hyperoxic lung regions in pigs.
NOS and COX isoforms and abnormal microvessel responses to CO2 and H+ in hyperoxia-injured lungs.
Prolonged hypercapnia-evoked cerebral hyperemia via K(+) channel- and prostaglandin E(2)-dependent endothelial nitric oxide synthase induction.
Prolonged isoflurane anesthesia-induced acidosis decreases penile intracavernous pressure in rats.
Small for gestational age: a new insight?
Ultrasound improves tissue perfusion in ischemic tissue through a nitric oxide dependent mechanism.
[Effects of glutamine on alpha-sarcomeric actin and its mRNA expression of myocardium in rats with endotoxemia]
Acquired Immunodeficiency Syndrome
Absence of the inducible form of nitric oxide synthase in the brains of patients with the acquired immunodeficiency syndrome.
Antioxidants in infection.
Expression of inducible nitric oxide synthase in cytomegalovirus-infected glial cells of retinas from AIDS patients.
Identification by mRNA differential display of two up-regulated genes as candidate mediators of AIDS dementia.
Increased NADPH-diaphorase reactivity and cytokine expression in dorsal root ganglia in acquired immunodeficiency syndrome.
Nitric oxide mediates mecamylamine- and naloxone-precipitated nicotine withdrawal.
Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients.
Acute Chest Syndrome
ET-1 and ecNOS gene polymorphisms and susceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia.
ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia.
Nitric oxide metabolism and the acute chest syndrome of sickle cell anemia.
Acute Coronary Syndrome
Association of endothelial constitutive nitric oxide synthase gene polymorphism with acute coronary syndrome in Koreans.
Nitric oxide production by neutrophils obtained from patients during acute coronary syndromes: expression of the nitric oxide synthase isoforms.
Plasma total nitric oxide and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism: a study in a South Indian population.
Acute Kidney Injury
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality.
DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.
Decreased expression of brain nitric oxide synthase in macula densa cells and glomerular epithelial cells of rats with mercury chloride-induced acute renal failure.
Effect of inhibition of nitric oxide synthase in acute renal failure due to endotoxin shock in dogs.
Endotoxin-induced acute renal failure in rats: effects of L-arginine and nitric oxide synthase inhibition on renal function.
Estradiol attenuates ischemia reperfusion-induced acute kidney injury through PPAR-? stimulated eNOS activation in rats.
Hemodynamic response magnetic resonance imaging: application for renal hemodynamic characterization.
Increased nitric oxide synthase activity despite lack of response to endothelium-dependent vasodilators in postischemic acute renal failure in rats.
Involvement of nitric oxide in the suppressive effect of 17beta-estradiol on endothelin-1 overproduction in ischemic acute renal failure.
Nitric Oxide Protects against Ischemic Acute Renal Failure through the Suppression of Renal Endothelin-1 Overproduction.
Nitric oxide synthase inhibition and acute renal ischemia: effect on systemic hemodynamics and mortality.
Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats.
Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.
Role of angiotensin II, endothelin-1, and nitric oxide in HgCl2-induced acute renal failure.
Role of nitric oxide synthase activity in experimental ischemic acute renal failure in rats.
The impact of intrarenal nitric oxide synthase inhibition on renal blood flow and function in mild and severe hyperdynamic sepsis.
Acute Lung Injury
An Active Drimane-Type Lactone from Polygonum jucundum Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Through TLR4-MAPKs Signaling Pathway.
Beneficial Effects of Concomitant Neuronal and Inducible Nitric Oxide Synthase Inhibition in Ovine Burn and Inhalation Injury.
Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats.
Effect of ONO1714, a specific inducible nitric oxide synthase inhibitor, on lung lymph filtration and gas exchange during endotoxemia in unanesthetized sheep.
Effect of Radix Paeoniae Rubra on the expression of HO-1 and iNOS in rats with endotoxin-induced acute lung injury.
Effects of an endogenous nitric oxide synthase inhibitor on phorbol myristate acetate-induced acute lung injury in rats.
Effects of nitric oxide synthase inhibitors on systemic hypotension, cytokines and inducible nitric oxide synthase expression and lung injury following endotoxin administration in rats.
Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-?/Smad signaling pathway.
Lung ischemia reperfusion injury: the therapeutic role of dipeptidyl peptidase 4 inhibition.
Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine.
Nitric oxide mediates acute lung injury by modulation of inflammation.
ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits.
Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases.
Ovariectomy aggravates hypersensitivity reactions to paclitaxel in rats.
Pneumotoxicity of lipopolysaccharide in nitric oxide-deficient rats is limited by a thromboxane synthase inhibitor.
Protective effect of interleukin-1 receptor antagonist on oleic acid-induced lung injury.
Pulmonary expression of nitric oxide synthase isoforms in sheep with smoke inhalation and burn injury.
Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.
The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate.
[Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS].
[Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and transforming growth factor -?/Smad signaling pathway].
Acute Radiation Syndrome
The Ability of the Nitric Oxide Synthases Inhibitor T1023 to Selectively Protect the Non-Malignant Tissues.
Adenocarcinoma
Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer.
Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells.
Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation.
Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma.
Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.
Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion.
Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas.
Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma.
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line.
Reactivity of tumor-draining lymph nodes and the nitric oxide pathway.
Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells.
Role of phenolic compounds in nitric oxide synthase activity in colon and breast adenocarcinoma.
[Histocytospectrophotometric characteristics of lung cancer]
Adenocarcinoma of Lung
Significant correlation of nitric oxide synthase activity and p53 gene mutation in stage I lung adenocarcinoma.
Adenoma
Modulation of inducible nitric oxide synthase expression in rat intestinal cells by colon tumor promoters.
Adenoma, Pleomorphic
Are myoepithelial cells responsible for the widespread expression of inducible nitric oxide synthase in pleomorphic adenoma? An immunohistochemical study.
Expression of nitric oxide synthase in pleomorphic adenomas of the parotid.
Adenomatous Polyposis Coli
Nitric oxide synthase 2 mRNA expression in relation to p53 and adenomatous polyposis coli mutations in primary colorectal adenocarcinomas.
Aggressive Periodontitis
Nitric oxide synthase activity in neutrophils from patients with localized aggressive periodontitis.
Albuminuria
Genetic factors in diabetic nephropathy.
Reduction of albuminuria by angiotensin receptor blocker beyond blood pressure lowering: evaluation in megsin/receptor for advanced glycation end products/inducible nitric oxide synthase triple transgenic diabetic nephropathy mouse model.
Alkalosis
Multiple Ca(2+)-dependent modulators mediate alkalosis-induced vasodilation in newborn piglet lungs.
Studies of hypoxemic/reoxygenation injury: with aortic clamping. XIII. Interaction between oxygen tension and cardioplegic composition in limiting nitric oxide production and oxidant damage.
Altitude Sickness
B-type natriuretic peptide, vascular endothelial growth factor, endothelin-1, and nitric oxide synthase in chronic mountain sickness.
Decrease of asymmetric dimethylarginine predicts acute mountain sickness.
[Ketamine and L-NAME inhibit NOS and somatostatin mRNA expression induced by altitude hypoxia in the rat hypothalamus]
Alveolar Bone Loss
Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study.
Exenatide and Sitagliptin Decrease Interleukin 1?, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis.
Alzheimer Disease
Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration.
Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation.
Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid.
Alzheimer's disease: A contextual link with nitric oxide synthase.
Amyloid-? Decreases Nitric Oxide Production in Cultured Retinal Neurons: A Possible Mechanism for Synaptic Dysfunction in Alzheimer's Disease?
Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease.
Association of Cigarette Smoking With Cerebrospinal Fluid Biomarkers of Neurodegeneration, Neuroinflammation, and Oxidation.
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease.
Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease.
Decrease of TGF-beta1 plasma levels and increase of nitric oxide synthase activity in leukocytes as potential biomarkers of Alzheimer's disease.
Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease.
Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model.
Expression of nitric oxide system in clinically evaluated cases of Alzheimer's disease.
Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease.
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.
Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders.
NADPH diaphorase histochemistry of the human hypothalamus.
NADPH-diaphorase-containing neurons in cortex, subcortical white matter and neostriatum are selectively spared in Alzheimer's disease.
NADPH-diaphorase-positive cell populations in the human amygdala and temporal cortex: neuroanatomy, peptidergic characteristics and aspects of aging and Alzheimer's disease.
Naringin and Rutin Alleviates Episodic Memory Deficits in Two Differentially Challenged Object Recognition Tasks.
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease.
Neuronal nitric oxide synthase (nNOS) mRNA expression and NADPH-diaphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer's disease brains.
Neuroprotective properties of statins.
Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments.
Nitric Oxide Decreases the Enzymatic Activity of Insulin Degrading Enzyme in APP/PS1 Mice.
Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene delivery.
Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease.
Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies.
Nitric oxide-mediated regulation of ?-amyloid clearance via alterations of MMP-9/TIMP-1.
nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease.
No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease.
Oxidative Stress Induced Mitochondrial DNA Deletion as a Hallmark for the Drug Development in the Context of the Cardiovascular Diseases.
Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases.
Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.
Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells.
Sparing of NADPH-diaphorase striatal neurons in Parkinson's and Alzheimer's diseases.
Subset of neurons characterized by the presence of NADPH-diaphorase in human substantia innominata.
The nitric oxide synthase 3 G894T polymorphism associated with Alzheimer's disease risk: a meta-analysis.
The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease.
The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.
[Association between Alzheimer's disease and nitric oxide synthase III polymorphism]
[Inducible nitric oxide synthase induces beta-amyloid neurotoxicity in vivo].
[Reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with Alzheimer type dementia and aged controls]
Amblyopia
Expression of nitric oxide synthase in the retina of monocular deprivation amblyopia rats.
Amnesia
7-Nitro indazole, a neuron-specific nitric oxide synthase inhibitor, produces amnesia in the chick.
An inhibitor of nitric oxide synthesis prevents memory formation in the chick.
BACOPA MONNIERA ALLEVIATES L-NNA INDUCED BUT NOT MK801 INDUCED AMNESIA: A MOUSE MORRIS WATER MAZE STUDY.
Nitric oxide blockade in mediodorsal thalamus impaired nicotine/ethanol-induced memory retrieval in rats via inhibition of prefrontal cortical pCREB/CREB signaling pathway.
Nitric oxide in the nucleus accumbens is involved in retrieval of inhibitory avoidance memory by nicotine.
Possible interaction of hippocampal nitric oxide and calcium/calmodulin-dependent protein kinase II on reversal of spatial memory impairment induced by morphine.
Amyotrophic Lateral Sclerosis
Administration of nitric oxide synthase inhibitors does not alter disease course of amyotrophic lateral sclerosis SOD1 mutant transgenic mice.
Altered reaction of facial motoneurons to axonal damage in the presymptomatic phase of a murine model of familial amyotrophic lateral sclerosis.
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Decrease in Asymmetrical Dimethylarginine, an Endogenous Nitric Oxide Synthase Inhibitor, in Cerebrospinal Fluid during Elderly Aging and in Patients with Sporadic Form of Amyotrophic Lateral Sclerosis.
Expression of nitric oxide synthase in the spinal cord in amyotrophic lateral sclerosis.
Expression of nitric oxide synthase isoforms in spinal cord in amyotrophic lateral sclerosis.
Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis.
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.
Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation.
Nitric oxide synthase expression in cervical spinal cord in sporadic amyotrophic lateral sclerosis.
Partial loss of NADPH-diaphorase/nitric oxide synthase-complex in amyotrophic lateral sclerosis and human type-II myofiber atrophy.
Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients.
The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPH-diaphorase in the spinal cord of wobbler mouse, a model for amyotrophic lateral sclerosis.
Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis.
Anaphylaxis
A plant histaminase modulates cardiac anaphylactic response in guinea pig.
An inhibitor of nitric oxide synthase, N omega-nitro-L-arginine-methyl ester, attenuates hypotension but does not improve cardiac depression in anaphylaxis in dogs.
Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock.
Effects of hyperthermia pretreatment on expression of heme oxygenase-1 and nitric oxide synthase in rats subjected to experimental anaphylactic shock.
Methylene blue for clinical anaphylaxis treatment: a case report.
Methylene blue for refractory hypotension: a case report.
Nitric oxide synthase inhibition is detrimental to cardiac function and promotes bronchospasm in anaphylaxis in rabbits.
Pre-exposure to vasopressin potentiates the vasoconstrictive effect of epinephrine in rat aorta isolated during late anaphylaxis.
Role of nitric oxide in anaphylactic shock.
Role of nitric oxide production in anaphylaxis and its relevance for the treatment of anaphylactic hypotension with methylene blue.
Symptomatic and pathophysiological observations in a modified animal model of allergic rhinitis.
What's in a name? eNOS and anaphylactic shock.
Anemia
Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients.
Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells.
Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression.
High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anaemia.
Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway.
Inhibition of nitric oxide synthase isoforms by porphyrins.
Red blood cell nitric oxide synthase modulates red blood cell deformabilityin sickle cell anemia.
Anemia, Iron-Deficiency
Inhibition of nitric oxide synthase isoforms by porphyrins.
Up-regulation of renal and vascular nitric oxide synthase in iron-deficiency anemia.
Anemia, Sickle Cell
Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients.
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
High red blood cell nitric oxide synthase activation is not associated with improved vascular function and red blood cell deformability in sickle cell anaemia.
Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway.
Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition.
Nitric oxide in gingival crevicular fluid and nitric oxide synthase expression in the gingiva of patients with sickle cell disease.
Nitric oxide metabolism and the acute chest syndrome of sickle cell anemia.
Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin.
Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis.
Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease.
Red blood cell nitric oxide synthase modulates red blood cell deformabilityin sickle cell anemia.
Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation.
Aneurysm
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms.
Epidemiology and genetics of intracranial aneurysms.
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.
Nitric oxide in experimental aneurysm formation: early events and consequences of nitric oxide inhibition.
Relationship of genetic factors with development of aortic dissection and aneurysm.
Aneurysm, Dissecting
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.
Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice.
Relationship of genetic factors with development of aortic dissection and aneurysm.
Aneurysm, Ruptured
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms.
Angina, Unstable
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina.
Anosmia
Persistent c-fos expression and NADPH-d reactivity in the medulla and the lumbar spinal cord in rat with short-term peripheral anosmia.
Anovulation
[Comparative morphofunctional characteristics of the ovaries in women of reproduction age in the norm and with chronic anovulatory infertility]
Aortic Aneurysm
Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice.
Aortic Aneurysm, Abdominal
Experimental abdominal aortic aneurysms in mice lacking expression of inducible nitric oxide synthase.
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.
Neovascularization in the abdominal aortic aneurysm. Endothelial nitric oxide synthase, nitric oxide, and elastolysis.
Aortic Valve Stenosis
Aortic stenosis is associated with elevated plasma levels of asymmetric dimethylarginine (ADMA).
Aphakia
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
argininosuccinate synthase deficiency
Prenatal diagnosis of citrullinemia and argininosuccinic aciduria: evidence for a transmission ratio distortion in citrullinemia.
Argininosuccinic Aciduria
Requirement of argininosuccinate lyase for systemic nitric oxide production.
Arrhythmias, Cardiac
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Modulation of Cardiac Ventricular Excitability by GLP-1 (Glucagon-Like Peptide-1).
Nitric oxide mediates neuro-glial interaction that shapes Drosophila circadian behavior.
Protective effect of polydatin against ischemia/reperfusion injury in rat heart.
The role of cromakalim and a nitric oxide synthase blocker in cardiac arrhythmia in the intact baboon model.
Arteriosclerosis
Crosstalk between Oxidative and Nitrosative Stress and Arterial Stiffness.
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis.
Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model.
The PAI-1 Antagonist TM5441 Attenuates L-NAME-Induced Hypertension and Vascular Senescence.
Arteritis
Immunohistochemical study on inducible type of nitric oxide (iNOS), basic fibroblast growth factor (bFGF) and tumor growth factor-beta1 (TGF-beta1) in arteritis induced in rats by fenoldopam and theophylline, vasodilators.
Obliterative arteritis with nitric oxide synthase and HLA-DR expression in Crohn's colitis.
Arthralgia
Influence of temporomandibular joint pain on sleep patterns: role of nitric oxide.
Arthritis
Blockade of joint inflammation and secondary hyperalgesia by L-NAME, a nitric oxide synthase inhibitor.
Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis.
Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.
Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.
Design of isoform-selective inhibitors of nitric oxide synthase.
Effects of nitric oxide on neutrophil influx depends on the tissue: role of leukotriene B4 and adhesion molecules.
Endothelial dysfunction in rat adjuvant-induced arthritis: Up-regulation of the vascular arginase pathway.
In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuricae.
Inducible nitric oxide synthase is expressed in joints of goats in the late stage of infection with caprine arthritis encephalitis virus.
Influence of dipyridamole and its combination with NO donor or NO synthase inhibitor on adjuvant arthritis.
Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice.
Inhibitors of nitric oxide synthase in inflammatory arthritis.
Nitric oxide enhances cyclooxygenase activity in articular cartilage.
Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair.
Nitric oxide synthase and cyclooxygenases: distribution, regulation, and intervention in arthritis.
Suppression of arthritis by an inhibitor of nitric oxide synthase.
Suppression of inflammatory arthritis by simultaneous inhibition of nitric oxide synthase and NADPH oxidase.
The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.
The ubiquitin proteasome system and efficacy of proteasome inhibitors in diseases.
Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats.
Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.
[NADPH-diaphorase topochemistry in human and rat knee joint structures and its changes in experimental arthritis]
Arthritis, Experimental
Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.
In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuricae.
N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats.
Suppression of adjuvant arthritis and synovial macrophage inducible nitric oxide by N-iminoethyl-L-ornithine, a nitric oxide synthase inhibitor.
[NADPH-diaphorase topochemistry in human and rat knee joint structures and its changes in experimental arthritis]
Arthritis, Gouty
[Effect of Electroacupuncture on Synovial M 1/M 2 Macrophage Polarization in Rats with Acute Gouty Arthritis].
Arthritis, Infectious
Inhibition of nitric oxide synthase (NOS) aggravates Staphylococcus aureus septicaemia and septic arthritis.
Arthritis, Rheumatoid
A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.
Association of the nitric oxide synthase (eNOS) gene polymorphism with increased risk for both lupus glomerulonephritis and rheumatoid arthritis in a single genetically homogeneous population.
Increased expression of blood mononuclear cell nitric oxide synthase type 2 in rheumatoid arthritis patients.
Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity.
Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis.
Nitric oxide synthase is expressed in the lymphomononuclear cells of synovial fluid in patients with rheumatoid arthritis.
Plasma asymmetric dimethylarginine is related to anticitrullinated protein antibodies in rheumatoid arthritis of short duration.
Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2).
Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation.
Asthenozoospermia
Association of nitric oxide synthase 3 gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study.
Nitric oxide synthase and tyrosine nitration in idiopathic asthenozoospermia: an immunohistochemical study.
Asthma
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics.
Allergen-induced impairment of bronchoprotective nitric oxide synthesis in asthma.
Arginines Plasma Concentration and Oxidative Stress in Mild to Moderate COPD.
Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels.
Associations between nitric oxide synthase genes and exhaled NO-related phenotypes according to asthma status.
Asymmetric Dimethylarginine Potentiates Lung Inflammation in a Mouse Model of Allergic Asthma.
Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure.
Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes.
Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma.
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
Elevated nitric oxide synthase activity concurrent with antigen-induced airway hyperresponsiveness in rats.
Epithelially derived endothelin and nitric oxide in asthma.
Expired nitric oxide as a marker for childhood asthma.
Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma.
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells.
Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections.
Increased Ornithine-Derived Polyamines cause Airways Hyperresponsiveness in a Mouse Model of Asthma.
Inducible nitric oxide synthase (iNOS): role in asthma pathogenesis.
Induction of calcium-independent nitric oxide synthase by allergen challenge in sensitized rat lung in vivo.
Induction of nitric oxide synthase in asthma.
Inhibitory effect of di-catechol rooperol on VCAM-1 and iNOS expression in cytokine-stimulated endothelium.
Localization and distribution of NOS1 in murine airways.
Localization of inducible nitric oxide synthase and endothelial constitutive nitric oxide synthase in airway mucosa of toluene diisocyanate-induced asthma.
Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide?
Neuronal nitric oxide synthase is associated with airway obstruction in BALB/c mice exposed to ozone.
Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease.
Nitric oxide synthase in bronchial epithelium and nitric oxide metabolites in the lungs of rats with bronchial asthma after fenoterol inhalation.
Nitric oxide synthase in neurons in the nucleus dorsalis and ganglion nodosum of the vagus nerve and changes during inhalation of acetylcholine in normal conditions and in experimental bronchial asthma.
Nitric oxide synthase inhibition: therapeutic potential in asthma.
Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children.
Nitric oxide: a regulator of mast cell activation and mast cell-mediated inflammation.
NOS 1 is required for allergen-induced expression of NOS 2 in mice.
Overexpression of dimethylarginine dimethylaminohydrolase 1 attenuates airway inflammation in a mouse model of asthma.
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
Regulation of NO-producing function of the lungs with salmeterol.
Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects.
Safranal of Crocus sativus L. Inhibits Inducible Nitric Oxide Synthase and Attenuates Asthma in a Mouse Model of Asthma.
The "gianic faces" of nitric oxide in asthma: role for the inducible and the constitutive nitric oxide synthase isoforms.
The effect of the nitric oxide synthase inhibitor, L-NMMA, on sodium metabisulphite-induced bronchoconstriction and refractoriness in asthma.
Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.
[An experimental study on the effect of nitric oxide synthase in bronchial asthma]
[Arginine metabolism in bronchial asthma]
[Detection of ET-1, TNF-alpha, oxidative radicals in sera of asthmatics and in sera and lung tissue of asthmatic guinea pigs]
[Genomic medicine in the solution of pulmonological problems]
[Increased production of nitric oxide in the immediate and late asthmatic responses in guinea pigs]
[Increased production of nitric oxide in the immediate and late asthmatic responses in models of guinea pig experimental asthma]
[Lung NADPH-diaphorase in rats with experimental bronchial asthma]
[Nitric oxide synthase in neurons of the vagal nucleus dorsalis and ganglion nodosum and its changes following acetylcholine inhalation in the norm and in experimental bronchial asthma]
[The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude.]
[The role of nitric oxide and nitric oxide synthase in the pathogenesis of asthma]
[The role of nitric oxide in the pathogenesis of asthma]
Asthma, Occupational
Induction of nitric oxide synthase in a model of allergic occupational asthma.
Ataxia
An increase of neuropeptide Y but not nitric oxide synthase-immunoreactive nerves in the bladder neck from male patients with bladder neck dyssynergia.
Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: a comparison to other classes of antinociceptive agent.
Atherosclerosis
A possible involvement of crosstalk between advanced glycation end products (AGEs) and asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor in accelerated atherosclerosis in diabetes.
Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice.
ADMA/SDMA in elderly subjects with asymptomatic carotid atherosclerosis: values and site-specific association.
Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence.
Angiotensin-converting enzyme and endothelial constitutive nitric oxide synthase polymorphisms in Turkish renal transplant population and possible influence on renal artery atherosclerosis and graft survival.
Anti-atherosclerotic effects of vitamin E--myth or reality?
Apolipoprotein E polymorphism modulation of asymmetric dimethylarginine in hypertensive patients is determined by renal function.
Arginase type I as a marker of coronary heart disease in hemodialysis patients.
Asymmetric dimethyarginine as marker and mediator in ischemic stroke.
Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population.
Asymmetric dimethylarginine and coronary artery calcium scores are increased in patients infected with human immunodeficiency virus.
Asymmetric dimethylarginine as a risk marker for early-onset ischemic stroke in Indian population.
Asymmetric dimethylarginine triggers macrophage apoptosis via the endoplasmic reticulum stress pathway.
Asymmetric dimethylarginine: a molecule responsible for the coexistence of insulin resistance and atherosclerosis via dual nitric oxide synthase inhibition.
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
Asymmetrical dimethylarginine is related to renal function, chronic inflammation and macroangiopathy in patients with Type 2 diabetes and albuminuria.
Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.
Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease.
Atherosclerosis and oxidative stress.
Beyond blood pressure: the endothelium and atherosclerosis progression.
Calpain inhibitor attenuates atherosclerosis and inflammation in atherosclerotic rats through eNOS/NO/NF-?B pathway.
Crosstalk between Oxidative and Nitrosative Stress and Arterial Stiffness.
Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography.
Detrimental effects of a bout of physical exercise on circulating endogenous inhibitors of endothelial function in patients with coronary artery disease.
Down-regulation of endogenous nitric oxide synthase inhibitors on endothelial SK3 expression.
Effect of 17beta-estradiol in hypercholesterolemic rabbits with severe endothelial dysfunction.
Effect of Lowering Asymmetric Dimethylarginine (ADMA) on Vascular Pathology in Atherosclerotic ApoE-Deficient Mice with Reduced Renal Mass.
Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes.
Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis.
Endothelial damage, asymmetric dimethylarginine and cardiovascular risk in end-stage renal disease.
Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.
Genetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease.
High Plasma Dimethylarginine Levels are Associated with Adverse Clinical Outcome After Stroke.
Histochemical evidence for inducible nitric oxide synthase in advanced but non-ruptured human atherosclerotic carotid arteries.
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.
Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin.
Inducible and endothelial nitric oxide synthase expression in human atherogenesis: an immunohistochemical and ultrastructural study.
Inflammation may be a bridge connecting hypertension and atherosclerosis.
Influence of 12-week Nordic Walking training on biomarkers of endothelial function in healthy postmenopausal women.
Inhibitory effect of di-catechol rooperol on VCAM-1 and iNOS expression in cytokine-stimulated endothelium.
Initial validation of a novel rat model of vasculogenic erectile dysfunction with generalized atherosclerosis.
iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach.
Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction.
Kidney disease as an independent risk factor for cardiovascular events.
Lack of antioxidant activity of the antiatherogenic compound L-arginine.
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.
Methylentetrahydrofolate Reductase and Nitric Oxide Synthase Polymorphism in Patients with Atherosclerosis and Diabetes.
Modulation of the nitric oxide synthase pathway in atherosclerosis.
Nitric oxide synthase gene therapy for cardiovascular disease.
Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
Nitric oxide synthase plays a role in Chlamydia pneumoniae-induced atherosclerosis.
Non-invasive assessment of coronary flow reserve and ADMA levels: a case-control study of early rheumatoid arthritis patients.
Noninvasive metabolic syndrome model using an extremely small minipig, the microminipig.
NOS inhibition accelerates atherogenesis: reversal by exercise.
NOS1 Methylation and Carotid Artery Intima Media Thickness in Children.
Perilla Oil Reduces Fatty Streak Formation at Aortic Sinus via Attenuation of Plasma Lipids and Regulation of Nitric Oxide Synthase in ApoE KO Mice.
Pharmacological effects of xanthones as cardiovascular protective agents.
Plasma asymmetric dimethylarginine (ADMA), nitrate and the indices of low-density lipoprotein oxidation.
Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography.
Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis.
Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits.
Programmed cell death 5 suppresses AKT-mediated cytoprotection of endothelium.
Role of oxidative stress in atherosclerosis.
Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation.
Statins ameliorate atherosclerosis induced by inhibition of nitric oxide synthase: another novel vascular protective mechanism?
Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.
Tetrahydrobiopterin Inhibits PDGF-stimulated Migration and Proliferation in Rat Aortic Smooth Muscle Cells via the Nitric Oxide Synthase-independent Pathway.
The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity.
The effect of myocardial bridging of the coronary artery on vasoactive agents and atherosclerosis localization.
Tongxinluo Induces nNOS Expression Through ERK Activation: Possible Contribution to the Effects of Tongxinluo to Attenuate Vasoconstriction.
Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility.
[Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis]
[Influence of L-arginine on development of atherosclerosis: what is the therapeutically assured?]
[Relationship between nitric oxide synthase, endothelin and the initiation of hypertension and atherosclerosis]
[Therapeutic strategies in the treatment of endothelial dysfunction: facts and outlook]
Atrial Fibrillation
Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke.
Effects of Rosuvastatin on Serum Asymmetric Dimethylarginine Levels and Atrial Structural Remodeling in Atrial Fibrillation Dogs.
L-arginine, asymmetric dimethylarginine and rhythm outcome after electrical cardioversion for atrial fibrillation.
Thrombosis and occlusion of vascular access in hemodialyzed patients.
Atrioventricular Block
Atrial Sources of Reactive Oxygen Species Vary With the Duration and Substrate of Atrial Fibrillation: Implications for the Antiarrhythmic Effect of Statins.
Autoimmune Diseases
Aberrant timing in epidermal expression of inducible nitric oxide synthase after UV irradiation in cutaneous lupus erythematosus.
Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.
Detection of serum nitrite and nitrate in primary biliary cirrhosis: possible role of nitric oxide in bile duct injury.
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors.
Lack of inducible nitric oxide synthase activity in T cell clones and T lymphocytes from naive and Leishmania major-infected mice.
Modulation of autoimmune diseases by nitric oxide.
The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.
Bacteremia
Endotoxin versus bacteremia: a comparison focusing on clinical relevance.
Nitric oxide mediates redistribution of intrarenal blood flow during bacteremia.
Nitric oxide synthase inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia.
Bacterial Infections
Bacterial infection induces nitric oxide synthase in human neutrophils.
Effects of lipopolysaccharide on TNF-alpha production, hepatic NOS2 activity, and hepatic toxicity in rats with cirrhosis.
Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection.
Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections.
Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.
Stable expression in a Chinese hamster ovary (CHO) cell line of bioactive recombinant chelonianin, which plays an important role in protecting fish against pathogenic infection.
Bartter Syndrome
Abnormalities of Gq-mediated cell signaling in Bartter and Gitelman syndromes.
Behcet Syndrome
Evaluation of nitric oxide synthase activity, nitric oxide, and homocysteine levels in patients with active Behcet's disease.
Nitric oxide synthase and superoxide dismutase gene polymorphisms in Behçet disease.
Blindness
The promoter of inducible nitric oxide synthase implicated in glaucoma based on genetic analysis and nuclear factor binding.
Blister
From Polyplacophora to Cephalopoda: comparative analysis of nitric oxide signalling in mollusca.
Photosensitivity in lupus erythematosus.
Bone Neoplasms
Role of nitric oxide synthase in the development of bone cancer pain and effect of L?NMMA.
Bone Resorption
A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma.
Inhibition of nitric oxide synthase blocks osteoclastic bone resorption in adaptive bone modeling.
Nitric oxide synthase in tissues around failed hip prostheses.
Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats.
Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase.
Rac-GTPase, osteoclast cytoskeleton and bone resorption.
The C-Terminal Domain of Chondroadherin: A New Regulator of Osteoclast Motility Counteracting Bone Loss.
Borna Disease
Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes.
Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.
Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase.
Boutonneuse Fever
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.
Bradycardia
Altered nitroxidergic and NMDA receptor-mediated modulation of baroreflex-mediated heart rate in obese Zucker rats.
Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.
Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis.
Involvement of nitric oxide in the mediation of the hypotensive action of the essential oil of Mentha x villosa in normotensive conscious rats.
Nitric oxide synthases in vagal neurons are crucial for the regulation of heart rate in awake dogs.
Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery.
The role of nitric oxide in the control by the vagal nerves of the heart of the ferret.
Brain Concussion
Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury.
Brain Contusion
Nitric oxide synthase expression after human brain contusion.
Brain Death
A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.
Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death.
Brain Diseases
Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase.
Cognitive deficits after systemic induction of inducible nitric oxide synthase: a randomised trial in rats.
Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.
Retraction. Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase.
[Effects of Ginaton on nitric oxide and nitric oxide synthase in patients with delayed encephalopathy after carbon monoxide poisoning].
Brain Edema
Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema.
Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide.
Nitric oxide synthase immunoreactivity related to cold-induced brain edema.
Production of nitrite by primary rat astrocytes in response to pneumococci.
Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion.
The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.
[Effects of Cinnabar and Realgar in Angong Niuhuang powder on heat shock protein, nitric oxide synthase and inflammatory cytokines in contusion cerebral edema]
Brain Infarction
Association between the Glu298Asp polymorphism in the endothelial constitutive nitric oxide synthase gene and brain infarction. The GENIC Investigators.
Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia.
Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia.
Brain Injuries
A narrow therapeutical window of a nitric oxide synthase inhibitor against transient ischemic brain injury.
A new antioxidant compound H-290/51 attenuates nitric oxide synthase and heme oxygenase expression following hyperthermic brain injury. An experimental study using immunohistochemistry in the rat.
Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.
Alterations of inducible and constitutive nitric oxide synthase after hippocampal injury in rats.
Effect of nitric oxide synthase inhibition on cerebral blood flow and injury volume during focal ischemia in cats.
Estrogen and the brain: beyond ER-alpha and ER-beta.
Expression of NADPH-diaphorase (NOS) in rat hypothalamo-neurohypophysial system after ischemic and traumatic brain injury.
Free radical pathways in CNS injury.
Identification of a by-product of nitric oxide synthase activity in human acute brain injury with in vivo proton magnetic resonance spectroscopy.
Influence of exercise training on ischemic brain injury in type 1 diabetic rats.
Inhibition of nitric oxide synthase aggravates brain injury in diabetic rats with traumatic brain injury.
Interleukin-1 in cerebral ischemia.
Melatonin regulates nitric oxide synthase expression in ischemic brain injury.
Nitric oxide synthase in hypoxic or ischemic brain injury.
Organophosphate-induced brain injuries: delayed apoptosis mediated by nitric oxide.
Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury.
The influence of chronic moderate ethanol administration on NADPH-diaphorase (nitric oxide synthase) activity in rat brain.
The protective effect of aminoguanidine on cerebral ischemic damage in the rat brain.
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
Vigorous Exercise Training Improves Reactivity of Cerebral Arterioles and Reduces Brain Injury Following Transient Focal Ischemia.
[Effect of hyperbaric oxygen on the expression of nitric oxide synthase mRNA in cortex after acute traumatic cerebral injury].
Brain Injuries, Diffuse
[Effects of nitric oxide synthase inhibitor on dentate gyrus neurogenesis after diffuse brain injury in adult rats]
Brain Injuries, Traumatic
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality.
Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat.
Effects of moderate hypothermia on constitutive and inducible nitric oxide synthase activities after traumatic brain injury in the rat.
Effects of moderate, central fluid percussion traumatic brain injury on nitric oxide synthase activity in rats.
Endogenous nitric-oxide synthase inhibitor ADMA after acute brain injury.
Expression of NADPH-diaphorase (NOS) in rat hypothalamo-neurohypophysial system after ischemic and traumatic brain injury.
Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat.
Expression of the inducible nitric oxide synthase in distinct cellular types after traumatic brain injury: an in situ hybridization and immunocytochemical study.
Induction of nitric oxide synthase by traumatic brain injury.
Inhibition of nitric oxide synthase aggravates brain injury in diabetic rats with traumatic brain injury.
Inhibition of nitric oxide synthase potentiates hypertension and increases mortality in traumatically brain-injured rats.
Mercaptoethylguanidine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expressions induced in rats after fluid-percussion brain injury.
Neuroprotective effect of allicin against traumatic brain injury via Akt/endothelial nitric oxide synthase pathway-mediated anti-inflammatory and anti-oxidative activities.
Nitric oxide synthase expression after human brain contusion.
Nitric Oxide Synthase Inhibition with the Antipterin VAS203 Improves Outcome in Moderate and Severe Traumatic Brain Injury: A Placebo-Controlled Randomized Phase IIa Trial (NOSTRA).
Reduction of the neurological deficit in mice with traumatic brain injury by nitric oxide synthase inhibitors.
Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury.
Simvastatin attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
Simvastatin combined with antioxidant attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
Suppression of cortical TRPM7 protein attenuates oxidative damage after traumatic brain injury via Akt/endothelial nitric oxide synthase pathway.
Suppression of the inducible form of nitric oxide synthase prior to traumatic brain injury improves cytochrome c oxidase activity and normalizes cellular energy levels.
The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.
Brain Ischemia
A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat.
A Pentapeptide Monocyte Locomotion Inhibitory Factor Protects Brain Ischemia Injury by Targeting the eEF1A1/Endothelial Nitric Oxide Synthase Pathway.
Altered histochemical staining with reduced nicotinamide adenine dinucleotide phosphate diaphorase in Mongolian gerbil brain after cerebral ischemia.
Antioxidant effect of N omega-nitro-L-arginine methyl ester (L-NAME) on global cerebral ischemia in a rat model.
Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice.
Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling.
Biphasic enhancement of nitric oxide synthase activity and cGMP level following brain ischemia in gerbils.
Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat.
Contribution of nitric oxide synthase (NOS) activity in blood-brain barrier disruption and edema after acute ischemia/reperfusion in aortic coarctation-induced hypertensive rats.
Contribution of nitric oxide synthase (NOS) in blood-brain barrier disruption during acute focal cerebral ischemia in normal rat.
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion in the rat pup.
Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion.
Damage to neurons and oligodendrocytes in the hippocampal CA1 sector after transient focal ischemia in rats.
DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study.
Effect of desmethyl tirilazad, dizocilpine maleate and nimodipine on brain nitric oxide synthase activity and cyclic guanosine monophosphate during cerebral ischemia in rats.
Effect of intermittent reperfusion and nitric oxide synthase inhibition on infarct volume during reversible focal cerebral ischemia.
Effect of magnesium on nitric oxide synthase of neurons in cortex during early period of cerebral ischemia.
Effect of tirilazad on brain nitric oxide synthase activity during cerebral ischemia in rats.
Effects of central inhibition of nitric oxide synthase on focal cerebral ischemia in rats.
Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia.
Effects of inhibition of nitric oxide synthase on blood-brain barrier transport in focal cerebral ischemia.
Effects of nitric oxide synthase inhibition on brain infarction in SOD-1-transgenic mice following transient focal cerebral ischemia.
Effects of sodium magnesium fructose diphosphate on free calcium concentration and nitric oxide synthase activity of ischemic synaptosome.
Effects of VEGF and nitric oxide synthase inhibition on blood-brain barrier disruption in the ischemic and non-ischemic cerebral cortex.
Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor.
Failure to prevent selective CA1 neuronal death and reduce cortical infarction following cerebral ischemia with inhibition of nitric oxide synthase.
Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia.
Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia.
G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene.
Induction of NADPH-diaphorase activity in the hippocampus in a rat model of cerebral ischemia and ischemic tolerance.
Induction of NADPH-diaphorase activity in the rat forebrain after middle cerebral artery occlusion.
Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia.
Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage.
Inhibition of nitric oxide synthase increases extracellular cerebral glutamate concentration after global ischemia.
Inhibition of nitric oxide synthase with 7-nitroindazole does not modify early metabolic recovery following focal cerebral ischemia in rats.
Inhibition of sevoflurane postconditioning against cerebral ischemia reperfusion-induced oxidative injury in rats.
Inhibitory role of N omega-nitro-L-arginine methyl ester (L-NAME), a potent nitric oxide synthase inhibitor, on brain malondialdehyde and conjugated diene levels during focal cerebral ischemia in rats.
Is intracellular brain pH a dependent factor in NOS inhibition during focal cerebral ischemia?
Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury?
Lubeluzole following traumatic brain injury in the rat.
Marked induction of calcium-independent nitric oxide synthase activity after focal cerebral ischemia.
Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia.
Modulation of cerebral RAGE expression following nitric oxide synthase inhibition in rats subjected to focal cerebral ischemia.
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by local nitric oxide synthase inhibition.
Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition.
Neuroprotective efficacy of N omega-nitro-L-arginine after focal cerebral ischemia in the mouse and inhibition of cortical nitric oxide synthase.
Neuroprotective properties of statins.
Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells.
Nitric oxide production during focal cerebral ischemia in rats.
Nitric oxide synthase expression in cerebral ischemia: neurochemical, immunocytochemical, and molecular approaches.
Nitric oxide synthase in cerebral ischemia. Possible contribution of nitric oxide synthase activation in brain microvessels to cerebral ischemic injury.
Nitric oxide synthase inhibition alters cerebral blood flow and oxygen balance in focal cerebral ischemia in rats.
Nitric oxide synthase inhibition and delayed cerebral injury after severe cerebral ischemia in fetal sheep.
Nitric oxide synthase inhibition attenuates delayed vasodilation and increases injury after cerebral ischemia in fetal sheep.
Nitric oxide synthase inhibition by L-NAME during repetitive focal cerebral ischemia in rabbits.
Nitric oxide synthase inhibition by L-NAME prevents brain acidosis during focal cerebral ischemia in rabbits.
Nitric oxide synthase inhibition reduces caudate injury following transient focal ischemia in cats.
Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats.
Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: In vitro and in vivo evaluation.
Repeated, short-term ischemia augments bradykinin-mediated opening of the blood-tumor barrier in rats with RG2 glioma.
Role of nitric oxide in pathogenesis underlying ischemic cerebral damage.
Roles of nitric oxide in brain hypoxia-ischemia.
Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage.
Temporal profiles of Ca2+/calmodulin-dependent and -independent nitric oxide synthase activity in the rat brain microvessels following cerebral ischemia.
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
The effect of nitric oxide synthase inhibition on infarct volume after reversible focal cerebral ischemia in conscious rats.
The effects of nitric oxide synthase inhibitor, L-NAME on NO production during focal cerebral ischemia in rats: could L-NAME be the future treatment of sudden deafness?
The role of nitric oxide synthase inhibition in the adverse effects of etomidate in the setting of focal cerebral ischemia in rats.
Time course of nitric oxide synthase activity in neuronal, glial, and endothelial cells of rat striatum following focal cerebral ischemia.
Transcriptional activation following cerebral ischemia in mice of a promoter-deleted nitric oxide synthase-2 gene.
Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1.
[Effect of +Gz-induced cerebral ischemia on the distribution of nitric oxide synthase in rabbit brain]
[Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils]
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat]
[The effect of electro-acupuncture on endogenous EPCs and serum cytokines in cerebral ischemia-reperfusion rat].
Brain Neoplasms
Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere Generation.
Nitric oxide synthase expression and enzymatic activity in human brain tumors.
Roles of nitric oxide and polyamines in brain tumor growth.
[Nitric oxide synthase in neuroepithelial brain tumors]
Breast Neoplasms
Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line.
Cancer cell metabolism and the modulating effects of nitric oxide.
Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer.
Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer.
EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase.
Electrophoretic assay of specific estrogen receptors: a contribution to methodology.
Endothelial cell nitric oxide synthase in peritumoral microvessels is a favorable prognostic indicator in premenopausal breast cancer patients.
Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells.
High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer.
Identification of genes and pathways associated with MDR in MCF-7/MDR breast cancer cells by RNA-seq analysis.
Impaired binding of insulin to erythrocyte membrane receptor and the activation of nitric oxide synthase by the hormone in human breast cancer.
Impairment of stimulation by estrogen of insulin-activated nitric oxide synthase in human breast cancer.
In vitro generation of peroxynitrite by 2- and 4-hydroxyestrogens in the presence of nitric oxide.
Inhibition of Tumor Progression by NG-Nitro-L-arginine Methyl Ester in 7,12- dimethylbenz(a)anthracene Induced Breast Cancer: Nitric Oxide Synthase Inhibition as an Antitumor Prevention.
Investigations on the inducible and endothelial nitric oxide synthases in human breast cancer cell line MCF-7 - estrogen has an influence on e-NOS, but not on i-NOS.
L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo.
Lack of association between NOS3 Glu298Asp and breast cancer risk: a case-control study.
Mitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: Implications for breast Cancer.
NG-nitro-L-arginine methyl ester inhibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model.
Nitric oxide decreases motility and increases adhesion in human breast cancer cells.
Nitric oxide synthase activity in human breast cancer.
Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation.
Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors.
Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors.
Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial.
Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer.
Opioids are non-competitive inhibitors of nitric oxide synthase in T47D human breast cancer cells.
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
Progesterone enhances cytokine-stimulated nitric oxide synthase II expression and cell death in human breast cancer cells.
Prognostic role of syncytin expression in breast cancer.
Role of phenolic compounds in nitric oxide synthase activity in colon and breast adenocarcinoma.
S-nitrosylation of Ras in breast cancer.
Simultaneous expression of nitric oxide synthase and estrogen receptor in human breast cancer cell lines.
Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase.
Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour.
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer.
Tumor growth enhancing effects of vascular endothelial growth factor are associated with increased nitric oxide synthase activity and inhibition of apoptosis in human breast carcinoma xenografts.
Bronchial Spasm
Methylene blue for clinical anaphylaxis treatment: a case report.
Nitric oxide synthase inhibition is detrimental to cardiac function and promotes bronchospasm in anaphylaxis in rabbits.
Role of nitric oxide in anaphylactic shock.
Bronchiolitis
Immunohistochemical localization of nitric oxide synthase and the oxidant peroxynitrite in lung transplant recipients with obliterative bronchiolitis.
Bunion
The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses.
Candidiasis
Susceptibility of germfree phagocyte oxidase- and nitric oxide synthase 2-deficient mice, defective in the production of reactive metabolites of both oxygen and nitrogen, to mucosal and systemic candidiasis of endogenous origin.
Carcinogenesis
Association of endothelial nitric oxide synthase (eNOS) polymorphisms with EGFR-mutated lung adenocarcinoma in Taiwan.
Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in inflammation and the risk of lung cancer: A case-control study in Japan.
Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis.
Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis.
Diagnosis, Staging, and Treatment of Cholangiocarcinoma.
Effects of nitric oxide synthase inhibition on diethylstilbestrol-induced hyperprolactinaemia and pituitary tumourigenesis in rats.
Effects of the T-786C, G894T, and Intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene on the risk of prostate cancer.
Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis.
Human cytomegalovirus may promote tumour progression by upregulating arginase-2.
Implication of nitric oxide synthase in carcinogenesis: analysis of the human inducible nitric oxide synthase gene.
Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival.
Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells.
Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse.
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms.
Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats.
Nitric oxide synthase and cytochrome c oxidase changes in the tumoural and peritumoural cerebral cortex.
Nitric oxide synthase type 3 is increased in squamous hyperplasia, dysplasia, and squamous cell carcinoma of the head and neck.
NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells.
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells.
Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression.
PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation.
Resveratrol as an anticancer nutrient: molecular basis, open questions and promises.
Studies on mode of action of hexaammine Co(III) chloride against diethylnitrosamine-induced hepatocarcinogenesis in mice.
Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells.
Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells.
The T -786C, G894T, and Intron 4 VNTR (4a/b) Polymorphisms of the Endothelial Nitric Oxide Synthase Gene in Prostate Cancer Cases.
U.S.-Japan Cooperative Cancer Research Program: seminar on nitric oxide synthase and carcinogenesis.
Carcinoma
?Np63?/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure.
Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa.
Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line.
Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2.
Ca2+/calmodulin-dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180.
Changes in the colonic enteric nervous system in rats with chemically induced colon dysplasia and carcinoma.
Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma.
Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism.
Distribution of nitric oxide synthase containing neurons in the rectal myenteric plexus and anal canal. Morphologic evidence that nitric oxide mediates the rectoanal inhibitory reflex.
Does type II nitric oxide synthase expression correlate with cellular proliferation in oral squamous cell carcinoma and dysplasia?
Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.
Electrophoretic assay of specific estrogen receptors: a contribution to methodology.
Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis.
Expression of iNOS--a favourable prognostic marker for early-stage carcinoma of the uterine cervix.
Expression of nitric oxide synthase in human gastric carcinoma and its relation to p53, PCNA.
Expression of nitric oxide synthase type 3 in reflux-induced esophageal lesions.
Expression of type 2 nitric oxide synthase and p21 in oral squamous cell carcinoma.
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck.
Immunohistochemical findings of nitric oxide synthase expression in urothelial transitional cell carcinoma including dysplasia.
Immunolocalization of inducible and constitutive nitric oxide synthases in human bladder cancer.
In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study.
Metabolism of L-arginine through polyamine and nitric oxide synthase pathways in proliferative or differentiated human colon carcinoma cells.
NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions.
Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns.
Nitric oxide synthase 2 (nos2) expression in histologically normal margins of oral squamous cell carcinoma.
NITRIC OXIDE SYNTHASE ACTIVITY AND ITS CONCENTRATION IN THE TISSUES OF HUMAN THYROID CARCINOMAS.
Nitric oxide synthase activity in human renal cell carcinoma.
Nitric oxide synthase activity in human squamous cell carcinoma of the head and neck.
Nitric oxide synthase expression and nitric oxide production in human colon carcinoma tissue.
Nitric oxide synthase expression is downregulated in basal cell carcinoma of the head and neck.
Nitric oxide synthase immunoreactivity in human bladder carcinoma.
Nitric oxide synthase inhibitor and IL-18 enhance the anti-tumor immune response of rats carrying an intrahepatic colon carcinoma.
Nitric oxide synthase type 3 is increased in squamous hyperplasia, dysplasia, and squamous cell carcinoma of the head and neck.
Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma.
The impact of immunohistochemical expression of nitric oxide synthases on clinical and pathological features of renal cell carcinoma.
The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
Type II nitric oxide synthase (NOS2) expression correlates with lymph node status in oral squamous cell carcinoma.
[Expression of inductive nitric oxide synthase and vascular endothelial growth factor in colonic carcinoma, and their effects on tumor angiogenesis]
[Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis]
[Histocytospectrophotometric characteristics of lung cancer]
Carcinoma, Adenoid Cystic
Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.
Carcinoma, Basal Cell
Nitric oxide synthase expression is downregulated in basal cell carcinoma of the head and neck.
Carcinoma, Hepatocellular
Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line.
Antitumoral gene-based strategy involving nitric oxide synthase type III overexpression in hepatocellular carcinoma.
Fresh aromatic herbs containing methylchavicol did not exhibit the pro-oxidative effects of pure methylchavicol on a human hepatoma cell line, HepG2.
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity.
Influence of NOS3 rs2070744 genotypes on hepatocellular carcinoma patients treated with lenvatinib.
Nitric Oxide Synthase Type III Overexpression By Gene Therapy Exerts Antitumoral Activity In Mouse Hepatocellular Carcinoma.
Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by insulin or insulin-like growth factor-I.
Suppression of hepatoma growth and angiogenesis by a fumagillin derivative TNP470: possible involvement of nitric oxide synthase.
Suppressive effect of endogenous regucalcin on nitric oxide synthase activity in cloned rat hepatoma H4-II-E cells overexpressing regucalcin.
[Expression and significance of nitric oxide synthase in human hepatocellular carcinoma]
[Nitric oxide synthase and vascular endothelial growth factor expression in hepatocellular carcinoma and their relation to angiogenesis]
Carcinoma, Non-Small-Cell Lung
Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer.
Influence of chemotherapy on nitric oxide synthase, indole-amine-2,3-dioxygenase and CD124 expression in granulocytes and monocytes of non-small cell lung cancer.
Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma.
Single nucleotide polymorphisms in NOS2A and NOS3 genes are not associated with treatment response of non-small cell lung cancer patients following the definitive radiochemotherapy.
Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of Kras mutation-positive, non-small cell lung cancer.
Carcinoma, Renal Cell
Nitric oxide synthase activity in human renal cell carcinoma.
The impact of immunohistochemical expression of nitric oxide synthases on clinical and pathological features of renal cell carcinoma.
Carcinoma, Squamous Cell
?Np63?/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure.
Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade.
Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck.
Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns.
Nitric oxide synthase activity in human squamous cell carcinoma of the head and neck.
Nitric oxide synthase inhibition enhances the antitumor effect of radiation in the treatment of squamous carcinoma xenografts.
Nitric oxide synthase type 3 is increased in squamous hyperplasia, dysplasia, and squamous cell carcinoma of the head and neck.
[Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis]
[Histocytospectrophotometric characteristics of lung cancer]
Carcinoma, Transitional Cell
Immunohistochemical findings of nitric oxide synthase expression in urothelial transitional cell carcinoma including dysplasia.
Carcinosarcoma
Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.
The comparative effects of the NOS inhibitor, Nomega-nitro-L-arginine, and the haemoxygenase inhibitor, zinc protoporphyrin IX, on tumour blood flow.
Cardiac Output, Low
Rationale, design and baseline characteristics of the PRO-TECT II study: PROpofol CardioproTECTion for Type II diabetics A randomized, controlled trial of high-dose propofol versus isoflurane preconditioning in patients undergoing on-pump coronary artery bypass graft surgery.
Cardio-Renal Syndrome
Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease.
The CAT-1 is out of the bag: endothelial Cationic Amino Acid Transporter-1 is a critical player in cardiorenal syndrome type 2.
Cardiomegaly
17beta-estradiol regulates constitutive nitric oxide synthase expression differentially in the myocardium in response to pressure overload.
Cardiac and Kidney Weight Indices following Dietary Salt Loading and/or Chronic Nitric Oxide Synthase Inhibition in the Hooded (Aguti) Rat.
Cardiac weight in hypertension induced by nitric oxide synthase blockade.
Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy.
Imeglimin prevents heart failure with preserved ejection fraction by recovering the impaired unfolded protein response in mice subjected to cardiometabolic stress.
Nitric Oxide Synthase Inhibition Abolishes Exercise-Mediated Protection against Isoproterenol-Induced Cardiac Hypertrophy in Female Mice.
Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy.
Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition.
Salt-induced cardiac hypertrophy is independent of blood pressure and endothelin in obese, heart failure-prone SHHF rats.
Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats.
Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension.
Cardiomyopathies
Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection.
Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase.
Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase.
Congenital absence of nitric oxide synthase 3 potentiates cardiac dysfunction and reduces survival in doxorubicin- and trastuzumab-mediated cardiomyopathy.
Differential regulation of nitric oxide synthase isoforms in experimental acute chagasic cardiomyopathy.
Doxorubicin-induced apoptosis: implications in cardiotoxicity.
Functional nitric oxide synthase mislocalization in cardiomyopathy.
Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance.
Influence of nitric oxide synthase inhibition and endothelin-1 receptor blockade on acetylcholine-induced coronary artery contraction in vitro in dilated and ischemic cardiomyopathies.
Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease.
Nitric oxide synthase expressions in ADR-induced cardiomyopathy in rats.
Retraction. Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase.
Superoxide anions contribute to impaired regulation of blood pressure by nitric oxide during the development of cardiomyopathy.
Cardiomyopathy, Dilated
Differential nitric oxide synthase activity in ischemic and idiopathic dilated cardiomyopathy.
Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy.
Endomyocardial nitric oxide synthase and the hemodynamic phenotypes of human dilated cardiomyopathy and of athlete's heart.
Increased nitric oxide production in heart failure.
Inhibition of endogenous nitric oxide synthase augments contractile response to adenylyl cyclase stimulation without altering mechanical efficiency in patients with idiopathic dilated cardiomyopathy.
Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease.
Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy.
Selective endothelin ET(B) receptor antagonist improves left ventricular function but exaggerates degeneration of cardiomyocytes in J2N-k hamsters.
Cardiomyopathy, Hypertrophic
[Polymorphism of angiotensin-converting enzyme and endothelial nitric oxide synthase genes in people with arterial hypertension, left ventricular hypertrophy, and hypertrophic cardiomyopathy]
Cardiotoxicity
Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.
Doxorubicin induced nitrosative stress is mitigated by Vitamin C via the modulation of nitric oxide synthases.
Cardiovascular Diseases
?3-adrenoreceptor stimulation protects against myocardial infarction injury via eNOS and nNOS activation.
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.
Assessment of protein-incorporated arginine methylation in biological specimens by CZE UV-detection.
Association of the AGXT2 V140I Polymorphism with Risk for Coronary Heart Disease in a Chinese Population.
Asymmetric dimethylarginine (ADMA) accelerates cell senescence.
Asymmetric Dimethylarginine (ADMA) Levels Are Lower in Hemodialysis Patients Treated With Paricalcitol.
Asymmetric dimethylarginine independently predicts fatal and nonfatal myocardial infarction and stroke in women: 24-year follow-up of the population study of women in Gothenburg.
Asymmetric Dimethylarginine Induced Apoptosis and Dysfunction of Endothelial Progenitor Cells: Role of Endoplasmic Reticulum Stress Pathway.
Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow.
Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches.
Asymmetric dimethylarginine: Is it a risk facgtor in the repair of aortic coarctation?
Asymptomatic Helicobacter pylori infection increases asymmetric dimethylarginine levels in healthy subjects.
Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease.
Circulating concentrations of asymmetrical dimethyl-L-arginine are increased in women with previous gestational diabetes.
Coronary endothelial dysfunction is associated with erectile dysfunction and elevated asymmetric dimethylarginine in patients with early atherosclerosis.
Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases.
Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine.
Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians.
Effect of acute variations of insulin and glucose on plasma concentrations of asymmetric dimethylarginine in young people with Type 1 diabetes.
Effects of Eicosapentaenoic Acid on Asymmetric Dimethylarginine in Patients in the Chronic Phase of Cerebral Infarction: A Preliminary Study.
Effects of intranasal versus oral hormone therapy on asymmetric dimethylarginine in healthy postmenopausal women: a randomized study.
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.
Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence.
Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm.
Functional and analytical evidence for scavenging of oxygen radicals by L-arginine.
Genetic determinants of cardiovascular disease: the Renin-Angiotensin-aldosterone system, paraoxonases, endothelin-1, nitric oxide synthase and adrenergic receptors.
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
Hormonal Regulation of Nitric Oxide (NO) in Cardio-Metabolic Diseases.
HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids.
Hydrogen sulfide defends against the cardiovascular risk of Nw-nitro-L-argininemethyl ester-induced hypertension in rats via the nitric oxide/endothelial nitric oxide synthase pathway.
Increased asymmetric dimethylarginine in vitamin B12 deficient adolescents.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Measurement of asymmetric dimethylarginine in plasma: methodological considerations and clinical relevance.
Nitric oxide and passive limb movement: a new approach to assess vascular function.
Nitric oxide synthase gene polymorphism and its influence on cardiovascular disease.
Nitric oxide synthase gene therapy for cardiovascular disease.
Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?
Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases.
NOS1 Methylation and Carotid Artery Intima Media Thickness in Children.
Novel aspects of oxidative stress in cardiovascular diseases.
p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity.
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
Pharmacogenetic association of NOS3 variants with cardiovascular disease in patients with hypertension: the GenHAT study.
Pioglitazone decreases asymmetric dimethylarginine (ADMA) levels in patients with impaired glucose intolerance or type 2 diabetes.
Plasma arginine/ADMA ratio as a sensitive risk marker for atherosclerosis: Shimane CoHRE study.
Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative.
Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2.
Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension.
Serum from young, sedentary adults who underwent passive heat therapy improves endothelial cell angiogenesis via improved nitric oxide bioavailability.
Serum Methylarginines and Hearing Loss in a Population-based Cohort of Older Adults.
Simplified HPLC methodology for quantifying biological pterins by selective oxidation.
Skeletal Muscle Vascular Control During Exercise: Impact of Nitrite Infusion During Nitric Oxide Synthase Inhibition in Healthy Rats.
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease.
The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling.
The inducible nitric oxide synthase in vascular and cardiac tissue.
The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats.
Variation at the Angiotensin-converting enzyme and endothelial nitric oxide synthase genes is associated with the risk of esophageal varices among patients with alcoholic cirrhosis.
[Effects of yi-fu-ning soft capsule on sex hormone, NO, NOS, SOD and MDA levels in ovariectomized rat serum]
Carotid Artery Diseases
Plasma asymmetric dimethylarginine is related to anticitrullinated protein antibodies in rheumatoid arthritis of short duration.
Catalepsy
Catalepsy induced by intra-striatal administration of nitric oxide synthase inhibitors in rats.
Catalepsy induced by nitric oxide synthase inhibitors.
Coadministration of L-NOARG and tiapride: effects on catalepsy in male mice.
Combined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice.
Ginkgo biloba leaf extract (EGb 761) enhances catalepsy induced by haloperidol and L-nitroarginine in mice.
L-NOARG, an inhibitor of nitric oxide synthase, induces catalepsy in mice.
l-NOARG-induced catalepsy can be influenced by glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus.
Nitric oxide synthase inhibitors do not substitute in rats trained to discriminate phencyclidine from saline.
Role of nitric oxide in experimental models of psychosis in rats.
Serotonin modulation of catalepsy induced by N(G)-nitro-L-arginine in mice.
Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice.
The effect of nitric oxide on fentanyl and haloperidol-induced catalepsy in mice.
Tolerance to the cataleptic effect that follows repeated nitric oxide synthase inhibition may be related to functional enzymatic recovery.
Cataract
Inhibitive effects of enhanced lipid peroxidation on Ca(2+)-ATPase in lenses of hereditary cataract ICR/f rats.
Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products.
Nitric oxide participates in cataract development in selenite-treated rats.
Cauda Equina Syndrome
Cauda equina syndrome and nitric oxide synthase immunoreactivity in the spinal cord of the dog.
Incipient cauda equina syndrome as a model of somatovisceral pain in dogs: spinal cord structures involved as revealed by the expression of c-fos and NADPH diaphorase activity.
Celiac Disease
Increased activity and expression of iNOS in human duodenal enterocytes from patients with celiac disease.
Significantly increased levels of nitric oxide products in urine of children with celiac disease.
Central Nervous System Diseases
Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system.
Neuroprotective properties of statins.
Protective role of endothelial nitric oxide synthase following pressure-induced insult to the optic nerve.
[Distribution of nitric oxide synthase activity in rat brain--analysis by high performance liquid chromatography]
Central Nervous System Neoplasms
Expression of nitric oxide synthase in human central nervous system tumors.
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
Cerebellar Diseases
Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury.
Cerebral Amyloid Angiopathy
Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2.
Cerebral Hemorrhage
Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression.
Induction of NADPH-diaphorase activity in the forebrain in a model of intracerebral hemorrhage and its inhibition by the traditional Chinese medicine complex Nao Yi An.
Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation.
[Study on the changes in endogenous oxidation agents and levels of anti-oxidation agents in patients with cerebral vascular disease]
Cerebral Infarction
Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion.
MTHFR C677T, FII G20210A, FV Leiden G1691A, NOS3 intron 4 VNTR, and APOE epsilon4 gene polymorphisms are not associated with spontaneous cervical artery dissection.
Protective effect of Panax quinquefolium 20(S)-protopanaxadiol saponins, isolated from Pana quinquefolium, on permanent focal cerebral ischemic injury in rats.
Cerebral Palsy
Effect of acupuncture on inflammatory cytokines expression of spastic cerebral palsy rats.
Symmetric Double-Headed Aminopyridines, a Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase.
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
Cerebrovascular Disorders
Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology.
Common genetic variation in DDAH2 is associated with intracerebral hemorrhage in Chinese population: a multicenter case-control study in China.
Lovastatin Reduces Apoptosis and Downregulates the CD40 Expression Induced by TNF-alpha in Cerebral Vascular Endothelial Cells.
Cervical Intraepithelial Neoplasia
Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia.
Chagas Disease
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice.
Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice.
NOS is present in the brain of Triatoma infestans and is colocalized with CCK.
Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase.
Cholera
Cerebellar nitric oxide synthase is expressed within granule cell patches innervated by specific mossy fiber terminals: a developmental profile.
Cytochrome oxidase and NADPH-diaphorase on the afferent relay branch of the optokinetic reflex in the opossum.
Evidence for peptide co-transmission in retrograde- and anterograde-labelled central nucleus of amygdala neurones projecting to NTS.
Identification of neurons with acetylcholinesterase and NADPH-diaphorase activities in the centrifugal visual system of the chick.
Immunohistochemical characterization of cardiac vagal preganglionic neurons in the rat.
Localization of the origin of retinal efferents in the turtle brain and the involvement of nitric oxide synthase.
Nitric oxide modulation of the immune response against cholera toxin-adjuvated ovalbumin administered by the intranasal route.
Nitric oxide producing neurones in the rat medulla oblongata that project to nucleus tractus solitarii.
Nitric oxide-synthesizing neurons in the hamster suprachiasmatic nucleus: a combined NOS- and NADPH- staining and retinohypothalamic tract tracing study.
Presence of neuronal nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal glands of the cat: an immunofluorescent and retrograde tracer double-labeling study.
The organization of cholinergic projections in the visual thalamus of the mouse.
Cholestasis
Effects of nitric oxide synthase inhibitor (L-NAME) on cytopathologic changes due to cholestasis in hepatic cells of adult male rats.
Hypothalamic nitric oxide synthase is depressed in cholestatic rats.
Inhibition by L-NA, a nitric oxide synthase inhibitor, of naloxone-precipitated withdrawal signs in a mouse model of cholestasis.
Liver metabolic zonation in rat biliary cirrhosis: distribution is reverse of that in toxic cirrhosis.
Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Cholestasis, Intrahepatic
Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study.
Cholesteatoma
A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma.
Choriocarcinoma
Attenuation of human chorionic gonadotropin release by nitric oxide in choriocarcinoma cell lines.
Garlic can induce both GTP cyclohydrolase and nitric oxide synthase activity in choriocarcinoma cells.
Choroidal Neovascularization
Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization.
Chronic Limb-Threatening Ischemia
Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve.
Chronic Periodontitis
Effectiveness of scaling and root planing versus modified Widman flap on nitric oxide synthase and arginase activity in patients with chronic periodontitis.
Immunoexpression of angiogenesis, nitric oxide synthase, and proliferation markers in gingival samples of patients with aggressive and chronic periodontitis.
Nitric oxide synthase in gingival tissues of patients with chronic periodontitis and with and without diabetes.
Ciliary Motility Disorders
Expression of nitric oxide synthases in primary ciliary dyskinesia.
Nasal nitric oxide and nitric oxide synthase expression in primary ciliary dyskinesia.
Citrullinemia
Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia.
Prenatal diagnosis of citrullinemia and argininosuccinic aciduria: evidence for a transmission ratio distortion in citrullinemia.
Cluster Headache
Analysis of nitric oxide synthase genes in cluster headache.
Analysis of NOS Gene Polymorphisms in Relation to Cluster Headache and Predisposing Factors in Sweden.
Coccidioidomycosis
High levels of interleukin-10 impair resistance to pulmonary coccidioidomycosis in mice in part through control of nitric oxide synthase 2 expression.
Coinfection
Co-infection of H9N2 Influenza A Virus and Escherichia coli in a BALB/c Mouse Model Aggravates Lung Injury by Synergistic Effects.
Immunopathology and cytokine responses in broiler chickens coinfected with Eimeria maxima and Clostridium perfringens with the use of an animal model of necrotic enteritis.
Colitis
All-Trans Retinoic Acid Modulates TLR4/NF-?B Signaling Pathway Targeting TNF-? and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon.
Biochemical and histopathological evidence for the beneficial effects of modafinil on the rat model of inflammatory bowel disease: involvement of nitric oxide pathway.
Colitis and interleukin 1beta up-regulate inducible nitric oxide synthase and superoxide dismutase in rat myenteric neurons.
Deletion of SOCS2 Reduces Post-Colitis Fibrosis via Alteration of the TGF? Pathway.
Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons.
Differing effects of two nitric oxide synthase inhibitors on experimental colitis.
Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats.
Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats.
Effects of nitric oxide synthase inhibition or sulfasalazine on the spontaneous colitis observed in HLA-B27 transgenic rats.
Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity.
Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers.
Heparin and low-molecular-weight heparin (enoxaparin) significantly ameliorate experimental colitis in rats.
Induction of iNOS in a rat model of acute colitis.
Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats.
Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice.
Intracolonic release of nitric oxide during trinitrobenzene sulfonic acid rat colitis.
L-arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of nuclear factor-?B/p65.
N-Methyl-d-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat.
Nitric oxide synthase immunoreactivity of interstitial cells of Cajal in experimental colitis.
Obliterative arteritis with nitric oxide synthase and HLA-DR expression in Crohn's colitis.
Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis.
Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice.
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis.
Role of inducible nitric oxide synthase in dextran sulphate sodium-induced colitis.
Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut inflammation.
Role of nitric oxide synthase inhibitor in experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.
Successful treatment of megacolon associated with colitis with a nitric oxide synthase inhibitor.
Sulphydryl blocker-induced rat colitis is ameliorated by intravenous injection of antibody to colonic surfactant-like particle.
The profiling of bioactives in Akebia trifoliata pericarp and metabolites, bioavailability and in vivo anti-inflammatory activities in DSS-induced colitis mice.
Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase.
Variable response to probiotics in two models of experimental colitis in rats.
[Altered colonic transit in TNBS-induced experimental colitis in guinea pig and distribution of nitric oxide synthase in the colonic wall]
Colitis, Collagenous
Expression of isoforms of nitric oxide synthase in collagenous colitis.
Colitis, Ulcerative
All-Trans Retinoic Acid Modulates TLR4/NF-?B Signaling Pathway Targeting TNF-? and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
Changes in distribution of three isoforms of nitric oxide synthase in ulcerative colitis.
Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
Excess nitric oxide in ulcerative colitis may be generated by nitric oxide synthase independent pathways.
Expression of cyclooxygenase-2 and nitric oxide synthase 2 in swine ulcerative colitis caused by Salmonella typhimurium.
Expression of inducible and endothelial nitric oxide synthases in pouchitis.
Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment.
Expression of nitric oxide synthase in ulcerative colitis.
High nitric oxide synthase activity in endothelial cells in ulcerative colitis.
Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis.
Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease.
Multidrug resistance gene and its relationship to ulcerative colitis and immune status of ulcerative colitis.
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
[Nitric oxide and inflammatory bowel disease]
Colitis-Associated Neoplasms
All-Trans Retinoic Acid Modulates TLR4/NF-?B Signaling Pathway Targeting TNF-? and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
Colonic Neoplasms
COX-2 and iNOS, good targets for chemoprevention of colon cancer.
Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice.
Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation.
Mitochondrial NOS1 suppresses apoptosis in colon cancer cells through increasing SIRT3 activity.
NO-donating aspirin inhibits both the expression and catalytic activity of inducible nitric oxide synthase in HT-29 human colon cancer cells.
Reduction of Inflammatory Hyperplasia in the Intestine in Colon Cancer-prone Mice by Water-extract of Cistanche deserticola.
Colorectal Neoplasms
Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer.
Effect of a nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on invasion of human colorectal cancer cell line SL-174T.
Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis.
High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer.
Immunohistochemical expression of cytokine induced nitric oxide synthase in colorectal carcinoma.
Increased in situ expression of nitric oxide synthase in human colorectal cancer.
Nitric oxide synthase 2 (NOS2) promoter polymorphisms in colorectal cancer.
Nitric oxide synthase 3 gene variants and colorectal cancer: a meta-analysis.
Nitric oxide synthase activity and expression in human colorectal cancer.
Nitric oxide synthase as a marker in colorectal carcinoma.
Nitric oxide synthase inhibitors 1400W and L-NIO inhibit angiogenesis pathway of colorectal cancer.
Coma
A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.
Communicable Diseases
Antioxidants in infection.
Congenital Abnormalities
Modulation of nuclear factor-?B signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice.
Nonfatal congenital alveolar dysplasia due to abnormalities of NO synthase isoforms.
Congenital Hypothyroidism
Changes in nitric oxide synthase levels are associated with impaired cardiac function and tolerance to ischemia-reperfusion injury in male rats with transient congenital hypothyroidism.
NADPH-d/NOS reactivity in the lumbar dorsal horn of congenitally hypothyroid pups before and after formalin pain induction.
The Effects of De-Whiskering and Congenital Hypothyroidism on The Development of Nitrergic Neurons in Rat Primary Somatosensory and Motor Cortices.
Conjunctivitis
Suppressive effect of antiflammin-2 on compound 48/80-induced conjunctivitis. Role of phospholipase A2s and inducible nitric oxide synthase.
Corneal Edema
Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis.
Transient corneal edema induced by nitric oxide synthase inhibition.
Corneal Neovascularization
Potential involvement of nitric oxide synthase but not inducible nitric oxide synthase in the development of experimental corneal neovascularization.
Coronary Artery Disease
An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men.
Association between the NOS3 (-786 T/C) and the ACE (I/D) DNA genotypes and early coronary artery disease.
Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients.
Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease.
Changes in ADMA and TAFI levels after stenting in coronary artery disease patients.
Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein.
Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery.
Genetic etiology of coronary artery disease considering NOS 3 gene variant rs1799983.
Identification of plasma vascular endothelia-cadherin as a biomarker for coronary artery disease in Type 2 diabetes mellitus patients.
Inhibition of nitric oxide synthesis in human epicardial coronary arteries and stenoses in relation to serum lipid level.
Levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and risk of coronary artery disease: A meta-analysis based on 4713 participants.
Nitric oxide synthase 3 genotypes and inflammatory markers in coronary artery disease patients.
Nitric oxide synthase gene transfer restores activity of circulating angiogenic cells from patients with coronary artery disease.
Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.
Plasma asymmetric dimethylarginine level and extent of lesion at coronary angiography.
Plasma nitric oxide concentrations and nitric oxide synthase gene polymorphisms in coronary artery disease.
Relations between ACE gene and ecNOS gene polymorphisms and resistive index in type 2 diabetic patients with nephropathy.
Relationship of Asymmetric Dimethylarginine With Penile Doppler Ultrasound Parameters in Men with Vasculogenic Erectile Dysfunction.
Role of the microRNA, miR-206, and its target PIK3C2? in endothelial progenitor cell function – potential link with coronary artery disease.
Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism.
Short-term transdermal estradiol enhances nitric oxide synthase III and estrogen receptor mRNA expression in arteries of women with coronary artery disease.
Significance of vascular nitric oxide synthase pathways in coronary artery disease: a multiple-level biomarker strategy.
Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.
Systemic nitric oxide synthase inhibition improves coronary flow reserve to adenosine in patients with significant stenoses.
The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men.
[Analysis of gene complexes predisposing to coronary atherosclerosis]
[Plasma asymmetric dimethylarginine and cystatin C levels in patients with coronary artery disease].
Coronary Disease
Asymmetric dimethylarginine, smoking, and risk of coronary heart disease in apparently healthy men: prospective analysis from the population-based Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg study and experimental data.
Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women.
Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE study.
Perindopril alters vascular angiotensin-converting enzyme, AT(1) receptor, and nitric oxide synthase expression in patients with coronary heart disease.
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
Positive association between rs10918859 of the NOS1AP gene and coronary heart disease in male Han Chinese.
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine.
Stent placement in patients with coronary heart disease decreases plasma levels of the endogenous nitric oxide synthase inhibitor ADMA.
[Age related changes of regulatory mechanisms of cardio-vascular system and significance of nitric oxide synthase in the norm and pathology.]
[Relationship of plasma nitric oxide concentration and the activity of nitric oxide synthase with coronary heart disease]
Coronary Occlusion
Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts.
Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
Coronary Restenosis
Changes in ADMA and TAFI levels after stenting in coronary artery disease patients.
Coronary Vasospasm
Is it all in the genes...? Nitric oxide synthase and coronary vasospasm.
Recombinant gene transfer of endothelial nitric oxide synthase augments coronary artery relaxations during hypoxia.
Cough
Pharmacology of bradykinin evoked coughing in guinea pigs.
COVID-19
Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin.
Craniocerebral Trauma
Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia.
creatine kinase deficiency
The transcriptional cascade associated with creatine kinase down-regulation and mitochondrial biogenesis in mice sarcoma.
Crohn Disease
Distribution and colocalization of nitric oxide synthase and calretinin in myenteric neurons of developing, aging, and Crohn's disease human small intestine.
Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis.
Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment.
In situ generation of nitric oxide by myenteric neurons but not by mononuclear cells of the human colon.
Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease.
Nitric oxide and chronic gut inflammation: controversies in inflammatory bowel disease.
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
Proteasome inhibition attenuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis.
[Nitric oxide and inflammatory bowel disease]
Cryptorchidism
Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism.
Cystic Fibrosis
Arginines Plasma Concentration and Oxidative Stress in Mild to Moderate COPD.
Asymmetric Dimethylarginine Contributes to Airway Nitric Oxide Deficiency in Patients with Cystic Fibrosis.
Locally produced relaxin may affect testis and vas deferens function in rats.
Mechanisms of NOS2 regulation by Rho GTPase signaling in airway epithelial cells.
Neutrophils enhance expression of inducible nitric oxide synthase in human normal but not cystic fibrosis bronchial epithelial cells.
Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis.
Reduction of neuronal and inducible nitric oxide synthase gene expression in patients with cystic fibrosis.
Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells.
Cystitis
Aminoguanidine, Selective Nitric Oxide Synthase Inhibitor, Ameliorates Cyclophosphamide-induced Hemorrhagic Cystitis by Inhibiting Protein Nitration and PARS Activation.
Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors.
Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder.
Expression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated rats.
Inhibition of nitric oxide synthase prevents muscarinic and purinergic functional changes and development of cyclophosphamide-induced cystitis in the rat.
Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide.
Pharmacological modulation of the micturition pattern in normal and cyclophosphamide pre-treated conscious rats.
Cystitis, Interstitial
A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis.
Effect of long-term oral L-arginine on the nitric oxide synthase pathway in the urine from patients with interstitial cystitis.
Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine.
Localization of constitutive nitric oxide synthase isoforms and the nitric oxide target enzyme soluble guanylyl cyclase in the human bladder.
Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections.
Cysts
Long-term consequences of prenatal exposure to lead on brain development in rats.
Proangiogenetic molecules, hypoxia-inducible factor-1alpha and nitric oxide synthase isoforms in ovarian endometriotic cysts.
[Comparative morphofunctional characteristics of the ovaries in women of reproduction age in the norm and with chronic anovulatory infertility]
[Remote consequences of prenatal exposure to lead on the brain development in rats]
Cytomegalovirus Infections
Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.
Death, Sudden, Cardiac
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.
Nitric Oxide Synthase 1 Adaptor Protein, an Emerging New Genetic Marker for QT Prolongation and Sudden Cardiac Death.
Systematic Meta-Analysis of the Association Between a Common NOS1AP Genetic Polymorphism, the QTc Interval, and Sudden Death.
Decompression Sickness
Delayed effect of nitric oxide synthase inhibition on the survival of rats after acute decompression.
Differential effects on nitric oxide synthase, heat shock proteins and glutathione in human endothelial cells exposed to heat stress and simulated diving.
Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription.
Dehydration
Central inhibition of nitric oxide synthase preferentially augments release of oxytocin during dehydration.
Changes in NADPH diaphorase activity in forebrain structures of the laminae terminalis after chronic dehydration.
Effects of nitric oxide on expressions of nitrosocysteine and calcium-activated potassium channels in the supraoptic nuclei and neural lobe of dehydrated rats.
Nitric oxide is involved in dehydration/drought tolerance in Poncirus trifoliata seedlings through regulation of antioxidant systems and stomatal response.
Nitric oxide reduces hydrogen peroxide accumulation involved in water stress-induced subcellular anti-oxidant defense in maize plants.
Role of nitric oxide in the regulation of renin and vasopressin secretion.
The subfornical organ: biochemical and neuroendocrine comparisons with the hypothalamo-neurohypophysial system.
Dementia
Ellagic acid prevents dementia through modulation of PI3-kinase-endothelial nitric oxide synthase signalling in streptozotocin-treated rats.
Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.
Identification by mRNA differential display of two up-regulated genes as candidate mediators of AIDS dementia.
Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients.
Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies.
The nitric oxide synthase-3 codon 298 polymorphism is not associated with late-onset sporadic Alzheimer's dementia and Lewy body disease in a sample from Hungary.
[Reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with Alzheimer type dementia and aged controls]
Dementia, Vascular
Increased HO-1 expression and decreased iNOS expression in the hippocampus from adult spontaneously hypertensive rats.
[Effect of Shengmaisan on learning and memory abilities and hippocampal nitric oxide synthase expression and neuronal apoptosis in rats with vascular dementia]
Demyelinating Diseases
A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.
Antisense blockade of inducible nitric oxide synthase in glial cells derived from adult SJL mice.
Increased nitric oxide levels and nitric oxide synthase isoform expression in the cerebellum of the taiep rat during its severe demyelination stage.
Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection.
The role of nitric oxide in multiple sclerosis.
Dengue
A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis.
Nitric oxide synthase expression correlates with death in an experimental mouse model of dengue with CNS involvement.
Dentin Sensitivity
The enigma of potassium ion in the management of dentine hypersensitivity: is nitric oxide the elusive second messenger?
Dermatitis, Allergic Contact
Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses.
Dermatitis, Atopic
Clinical application of nitric oxide synthase inhibitor for atopic dermatitis.
Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses.
Dermatitis, Contact
Calcitonin gene-related peptide and nitric oxide are involved in ultraviolet radiation-induced immunosuppression.
Dermatomyositis
Reduction expression of thrombomodulin and endothelial cell nitric oxide synthase in dermatomyositis.
Diabetes Complications
Does nitric oxide mediate autoimmune destruction of beta-cells? Possible therapeutic interventions in IDDM.
Selective impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated resistance arteries of the streptozotocin-induced diabetic rat.
Diabetes Insipidus
Constitutive nitric oxide synthase in hypothalami of normal and hereditary diabetes insipidus rats and mice: role of nitric oxide in osmotic regulation and its mechanism.
Diabetes Insipidus, Nephrogenic
Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms.
Diabetes Insipidus, Neurogenic
Vasoplegia in septic shock (review).
Diabetes Mellitus
Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.
Alterations in the nitric oxide synthase binding sites and non-adrenergic, non-cholinergic mediated smooth muscle relaxation in the diabetic rabbit bladder outlet: possible relevance to the pathogenesis of diabetic cystopathy.
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.
Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus.
Association of the endothelial nitric oxide synthase gene G894T polymorphism with the risk of diabetic nephropathy in Qassim region, Saudi Arabia-A pilot study.
Astaxanthin improves cognitive deficits from oxidative stress, nitric oxide synthase and inflammation through upregulation of PI3K/Akt in diabetes rat.
Autoradiographic localization of nitric oxide synthase binding sites in normal and diabetic rat corpus cavernosum.
Brain nitric oxides synthase in major pelvic ganglia of aged (LETO) and diabetic (OLETF) rats.
Diabetes mellitus increases nitric oxide synthase in penises but not in major pelvic ganglia of rats.
Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
Diabetic urethropathy compounds the effects of diabetic cystopathy.
Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats.
Effect of diabetes and insulin treatment on nitric oxide synthase content in rat corpus cavernosum.
Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats.
Effects of Supervised Structured Aerobic Exercise Training Program on Interleukin-6, Nitric Oxide Synthase-1, and Cyclooxygenase-2 in Type 2 Diabetes Mellitus.
Expression of the inducible isoform of nitric oxide synthase in the retinas of human subjects with diabetes mellitus.
Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: Role of Ca(2+)/calmodulin-activated protein kinase II.
Gestational diabetes affects platelet behaviour through modified oxidative radical metabolism.
Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus.
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Increased superoxide production in hypertensive patients with diabetes mellitus: role of nitric oxide synthase.
Influence of nitric oxide synthase and kinin antagonists on metabolic parameters in chronic streptozotocin-induced diabetes mellitus.
Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice.
Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
New diagnostic and therapeutic possibilities for diastolic heart failure.
Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.
Nitric oxide synthase gene therapy for cardiovascular disease.
Pioglitazone decreases asymmetric dimethylarginine (ADMA) levels in patients with impaired glucose intolerance or type 2 diabetes.
Platelet signalling abnormalities in patients with type 2 diabetes mellitus: a review.
Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation.
Regular physical exercise normalizes elevated asymmetrical dimethylarginine concentrations in patients with type 1 diabetes mellitus.
RIPK3 blockade attenuates tubulointerstitial fibrosis in a mouse model of diabetic nephropathy.
Selective impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated resistance arteries of the streptozotocin-induced diabetic rat.
The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men.
The effect of pioglitazone on nitric oxide synthase in patients with type 2 diabetes mellitus.
The joint effect of the endothelin receptor B gene (EDNRB) polymorphism rs10507875 and nitric oxide synthase 3 gene (NOS3) polymorphism rs869109213 in Slovenian patients with type 2 diabetes mellitus and diabetic retinopathy.
Transdermal oestradiol replacement therapy enhances platelet constitutive nitric oxide synthase activity in postmenopausal women with type 2 diabetes mellitus.
Diabetes Mellitus, Type 1
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.
Characterization of the sphingomyelin content of isolated pancreatic islets. Evaluation of the role of sphingomyelin hydrolysis in the action of interleukin-1 to induce islet overproduction of nitric oxide.
Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients.
Effect of L-arginine-nitric oxide system on chemical-induced diabetes mellitus.
Exercise training normalizes impaired NOS-dependent responses of cerebral arterioles in type 1 diabetic rats.
Improving effect of combined inorganic nitrate and nitric oxide synthase inhibitor on pancreatic oxidative stress and impaired insulin secretion in streptozotocin induced-diabetic rats.
Influence of low density lipoprotein from insulin-dependent diabetic patients on platelet functions.
Inhibition of nitric oxide formation by aminoguanidine: an attempt to prevent insulin-dependent diabetes mellitus.
Inhibition of Rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes.
Interleukin 1beta-mediated inhibition of arginase in RINm5F cells.
Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes.
Platelet cNOS activity is reduced in patients with IDDM and NIDDM.
Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.
Regular physical exercise normalizes elevated asymmetrical dimethylarginine concentrations in patients with type 1 diabetes mellitus.
S-methyl-L-thiocitrulline counteracts interleukin 1 beta induced suppression of pancreatic islet function in vitro, but does not protect against multiple low-dose streptozotocin-induced diabetes in vivo.
Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells.
Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS.
Diabetes Mellitus, Type 2
A common variant of NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes.
A variation in NOS1AP gene is associated with repaglinide efficacy on insulin resistance in type 2 diabetes of Chinese.
Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway.
Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1.
Altered vasodilator role of nitric oxide synthase in the pancreas, heart and brain of rats with spontaneous type 2 diabetes.
Amino acid metabolism reflecting arginase activity is increased in patients with type 2 diabetes and associated with endothelial dysfunction.
Angiotensin-converting enzyme activity is involved in the mechanism of increased endogenous nitric oxide synthase inhibitor in patients with type 2 diabetes mellitus.
Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in Chinese subjects with type 2 diabetes.
Association of nitric oxide synthase 3 gene polymorphism with the risk of type 2 diabetes.
Association of the endothelial nitric oxide synthase gene G894T polymorphism with the risk of diabetic nephropathy in Qassim region, Saudi Arabia-A pilot study.
Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes.
Blunted response to systemic nitric oxide synthase inhibition in the cerebral circulation of patients with Type 2 diabetes.
Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients.
Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus.
Effects of 24-week treatment with acarbose on glucagon-like peptide 1 in newly diagnosed type 2 diabetic patients: a preliminary report.
Effects of Supervised Structured Aerobic Exercise Training Program on Interleukin-6, Nitric Oxide Synthase-1, and Cyclooxygenase-2 in Type 2 Diabetes Mellitus.
Expression levels of enzymes generating NO and CO in islets of murine and human diabetes.
G Protein-Coupled Receptor Kinase 2, With ?-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta.
Gestational diabetes affects platelet behaviour through modified oxidative radical metabolism.
Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase mu knockout mice.
Glutathione S-Transferase (GSTT1 rs17856199) and Nitric Oxide Synthase (NOS2 rs2297518) Genotype Combination as Potential Oxidative Stress-Related Molecular Markers for Type 2 Diabetes Mellitus.
Hyperfiltration, nitric oxide, and diabetic nephropathy.
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes.
Kininase 1 As a Preclinical Therapeutic Target for Kinin B1 Receptor in Insulin Resistance.
Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.
Nitric Oxide Synthase 2 Polymorphisms (rs2779248T/C and rs1137933C/T) and the Risk of Type 2 Diabetes in Zahedan, Southeastern Iran.
Nitric oxide synthase gene polymorphisms and nephropathy in Asians with Type 2 diabetes.
Nitric oxide synthase in skeletal muscle fibers of patients with type 2 diabetes.
Nitric oxide synthase inhibition reduces glucose uptake during exercise in individuals with type 2 diabetes more than in control subjects.
Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects.
Platelet cNOS activity is reduced in patients with IDDM and NIDDM.
Platelet signalling abnormalities in patients with type 2 diabetes mellitus: a review.
Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation.
Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species.
The effect of pioglitazone on nitric oxide synthase in patients with type 2 diabetes mellitus.
The joint effect of the endothelin receptor B gene (EDNRB) polymorphism rs10507875 and nitric oxide synthase 3 gene (NOS3) polymorphism rs869109213 in Slovenian patients with type 2 diabetes mellitus and diabetic retinopathy.
Transdermal oestradiol replacement therapy enhances platelet constitutive nitric oxide synthase activity in postmenopausal women with type 2 diabetes mellitus.
Diabetic Angiopathies
Blockade of chronic high glucose-induced endothelial apoptosis by Sasa borealis bamboo extract.
Diabetic Cardiomyopathies
Altered contractile response due to increased beta3-adrenoceptor stimulation in diabetic cardiomyopathy: the role of nitric oxide synthase 1-derived nitric oxide.
Cardiac oxidative stress is elevated at the onset of dilated cardiomyopathy in streptozotocin-diabetic rats.
Cobalt-Protoporphyrin Improves Heart Function by Blunting Oxidative Stress and Restoring NO Synthase Equilibrium in an Animal Model of Experimental Diabetes.
Role of nitric oxide in posthypoxic contractile dysfunction of diabetic cardiomyopathy.
Diabetic Foot
The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1.
Diabetic Ketoacidosis
Diabetic ketosis activates lymphomonocyte-inducible nitric oxide synthase.
Diabetic Nephropathies
-to: Rippin JD, Patel A, Belyaev ND, Gill GV, Barnett AH, Bain SC (2003) Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia 46:426-428.
A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy.
A meta-analysis on the relationship of eNOS 4b/a polymorphism and diabetic nephropathy susceptibility.
Amadori-configurated albumin induces nitric oxide-dependent apoptosis of endothelial cells: a possible mechanism of diabetic vasculopathy.
Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism.
Association of the endothelial nitric oxide synthase gene G894T polymorphism with the risk of diabetic nephropathy in Qassim region, Saudi Arabia-A pilot study.
Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes.
Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway.
Beraprost sodium, prostacyclin analogue, attenuates glomerular hyperfiltration and glomerular macrophage infiltration by modulating ecNOS expression in diabetic rats.
Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats.
Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats.
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-?B)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Down-regulation of nitric oxide synthase in the diabetic rabbit kidney: potential relevance to the early pathogenesis of diabetic nephropathy.
Effects of Folic Acid on Renal Endothelial Function in Patients with Diabetic Nephropathy: Results from a Randomized Trial.
Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy.
Glucagon-like peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.
High glucose increases inducible NO production in cultured rat mesangial cells. Possible role in fibronectin production.
Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy.
Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy.
Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals.
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.
Nitric oxide synthase derangements and hypertension in kidney disease.
Nitric oxide synthase gene polymorphisms and diabetic nephropathy.
Nitric oxide synthase inhibition in a spontaneously hypertensive rat model of diabetic nephropathy.
Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy.
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
Oxidative stress as a major culprit in kidney disease in diabetes.
Reduction of albuminuria by angiotensin receptor blocker beyond blood pressure lowering: evaluation in megsin/receptor for advanced glycation end products/inducible nitric oxide synthase triple transgenic diabetic nephropathy mouse model.
Renoprotective effects of a novel inhibitor of advanced glycation.
RIPK3 blockade attenuates tubulointerstitial fibrosis in a mouse model of diabetic nephropathy.
Role of renal nitric oxide synthase in diabetic kidney disease during the chronic phase of diabetes.
To: Rippin JD, Patel A, Belyaev ND, Gill GV, Barnett AH, Bain SC (2003) Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia 46:426-428.
Diabetic Neuropathies
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.
Effects of proinsulin C-peptide in experimental diabetic neuropathy: vascular actions and modulation by nitric oxide synthase inhibition.
Hyperalgesia and decreased neuronal nitric oxide synthase in diabetic rats.
Nitric oxide synthase activity and expression in experimental diabetic neuropathy.
Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats.
Diabetic Retinopathy
Bioinformatics analysis of diabetic retinopathy using functional protein sequences.
Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
Nitric oxide synthase 3 (NOS3) 4b/a, T-786C and G894T polymorphisms in association with diabetic retinopathy susceptibility: A meta-analysis.
Regulation of the early subnormal retinal oxygenation response in experimental diabetes by inducible nitric oxide synthase.
The joint effect of the endothelin receptor B gene (EDNRB) polymorphism rs10507875 and nitric oxide synthase 3 gene (NOS3) polymorphism rs869109213 in Slovenian patients with type 2 diabetes mellitus and diabetic retinopathy.
[Expression pattern of nitric oxide synthase in the retina of diabetic rats]
Disorders of Excessive Somnolence
Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence.
Disseminated Intravascular Coagulation
Effects of N omega-nitro-L-arginine methyl ester on the endotoxin-induced disseminated intravascular coagulation in porcine septic shock.
Down Syndrome
Molecular abnormalities of the brain in Down syndrome: relevance to Alzheimer's neurodegeneration.
VEGF and nitric oxide synthase immunoexpression in Down's syndrome amniotic fluid stem cells.
Drug Resistant Epilepsy
NADPH diaphorase reactive neurons in temporal lobe cortex of patients with intractable epilepsy and hippocampal sclerosis.
Drug-Related Side Effects and Adverse Reactions
Enhancement of bioreductive drug toxicity in murine tumours by inhibition of the activity of nitric oxide synthase.
Dry Eye Syndromes
Nitric oxide synthase induction and cytotoxic nitrogen-related oxidant formation in conjunctival epithelium of dry eye (Sjögren's syndrome).
Duodenal Ulcer
Bleeding duodenal ulcer and association with polymorphism of endothelial constitutive nitric oxide synthase gene.
Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients.
Dyskinesias
Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB/DeltaFosB expression.
Counteraction by Nitric Oxide Synthase Inhibitor of Neurochemical Alterations of Dopaminergic System in 6-OHDA-Lesioned Rats Under L-DOPA Treatment.
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease.
Interferon-? Involvement in the Neuroinflammation Associated with Parkinson's Disease and L-DOPA-Induced Dyskinesia.
Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease.
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
Nitric Oxide Synthase Inhibitor Improves De Novo and Long-Term l-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats.
Role of Nitric Oxide in Motor Control: Implications for Parkinson's Disease Pathophysiology and Treatment.
Dyslipidemias
Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome.
Lipids and endothelium-dependent vasodilation--a review.
Dystonia
Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia.
Striatal microinjections of nitric oxide synthase inhibitors and L-arginine fail to exert effects on paroxysmal dystonia in the dtsz mutant.
Eclampsia
Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia.
Ectromelia
Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication.
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.
Ectromelia, Infectious
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.
Eczema
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics.
Embolism, Air
Mechanisms of magnesium-induced vasodilation in cerebral penetrating arterioles.
Encephalitis
Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.
Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue.
Increased expression of nitric oxide synthase and dendritic injury in simian immunodeficiency virus encephalitis.
Inducible nitric oxide synthase is expressed in joints of goats in the late stage of infection with caprine arthritis encephalitis virus.
Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection.
The role of nitric oxide in multiple sclerosis.
Encephalitis, Japanese
Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role.
Encephalomyelitis
Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis.
An in Vitro Model of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis
An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients.
Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis.
Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response.
Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis.
Inhibition of nitric oxide synthase initiates relapsing remitting experimental autoimmune encephalomyelitis in rats, yet nitric oxide appears to be essential for clinical expression of disease.
Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat.
Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases.
Treatment of experimental autoimmune encephalomyelitis in rat by 1,25-dihydroxyvitamin D3 leads to early effects within the central nervous system.
Encephalomyelitis, Autoimmune, Experimental
Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis.
Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms.
An in Vitro Model of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis
An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients.
Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis.
Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase.
Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response.
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.
Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis.
Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis.
Inhibition of nitric oxide synthase initiates relapsing remitting experimental autoimmune encephalomyelitis in rats, yet nitric oxide appears to be essential for clinical expression of disease.
Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
Nitric oxide and the immunomodulation of experimental allergic encephalomyelitis.
Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis.
Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis.
Protective role of the cytokine-inducible isoform of nitric oxide synthase induction and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat.
Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases.
Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis.
Treatment of experimental autoimmune encephalomyelitis in rat by 1,25-dihydroxyvitamin D3 leads to early effects within the central nervous system.
End Stage Liver Disease
Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure.
Endolymphatic Hydrops
Effects of a nitric oxide synthase Type II inhibitor on compound action potential thresholds in experimental endolymphatic hydrops.
[Experimental endolymphatic hydrops under action of a type II nitric oxide synthase inhibitor: otoacoustic emissions evaluation and electrocochleography]
Endometrial Neoplasms
Cytoplasmic localization of endothelial constitutive nitric oxide synthase in endometrial carcinomas.
Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers.
Endometriosis
Increased expression of pattern recognition receptors and nitric oxide synthase in patients with endometriosis.
Prolonged gonadotropin-releasing hormone agonist therapy reduced expression of nitric oxide synthase in the endometrium of women with endometriosis and infertility.
[Influences of gonadotropin releasing hormone agonist treatment on nitric oxide synthase expression in women with endometriosis and infertility]
Endometritis
Endometrial nitric oxide synthase activity in mares susceptible or resistant to persistent breeding-induced endometritis and the effect of a specific iNOS inhibitor in vitro.
Nitric oxide levels and nitric oxide synthase expression in uterine samples from mares susceptible and resistant to persistent breeding-induced endometritis.
Endotoxemia
Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia.
Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice.
Alterations of gene expressions of preproET-1 and ET receptors in brains of endotoxemic Sprague-Dawley rats.
Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice.
Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia.
Detrimental effect of a non-selective nitric oxide synthase inhibitor on the energy state of the liver following acute endotoxemia in rabbits.
Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6.
Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.
Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response.
Effect of dexamethasone on nitric oxide synthase and Caspase-3 gene expressions in endotoxemia in neonate rat brain.
Effect of endotoxemia on plasma and tissue levels of nitric oxide metabolites and guanidino compounds.
Effect of NG-nitro-L-arginine-methyl-ester on cardiopulmonary function and biosynthesis of cyclooxygenase products during porcine endotoxemia.
Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep.
Effects of endotoxin on regulation of intestinal smooth muscle nitric oxide synthase and intestinal transit.
Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia.
Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.
Effects of selective nitric oxide synthase inhibition in hyperdynamic endotoxemia in dogs.
Effects of the nitric oxide synthase inhibitors N(G)-nitro-L-arginine methyl ester and aminoethyl-isothiourea on the liver microcirculation in rat endotoxemia.
Endotoxin versus bacteremia: a comparison focusing on clinical relevance.
Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia.
Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats.
Hemodynamic response to norepinephrine with and without inhibition of nitric oxide synthase in porcine endotoxemia.
Hepatic cytochrome P450 is directly inactivated by nitric oxide, not by inflammatory cytokines, in the early phase of endotoxemia.
Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducible nitric oxide synthase gene expression.
Hepatic oxygen metabolism in porcine endotoxemia: the effect of nitric oxide synthase inhibition.
Hepatocellular damage in porcine endotoxemia: beneficial effects of selective versus non-selective nitric oxide synthase inhibition?
HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro.
Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition.
Induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells.
L-arginine augments nitric oxide production and mesenteric blood flow in ovine endotoxemia.
Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors.
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats.
Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia.
Nitric oxide mediates hepatic cytochrome P450 dysfunction induced by endotoxin.
Nitric oxide synthase inhibition partially prevents decreased LV contractility during endotoxemia.
Nitric oxide synthase inhibition reduces venous return in porcine endotoxemia.
Nitric oxide synthase is not involved in cardiac contractile dysfunction in a rat model of endotoxemia without shock.
Nonselective versus selective inhibition of inducible nitric oxide synthase in experimental endotoxic shock.
Norepinephrine vs nitric oxide synthase inhibition in endotoxemia.
Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.
Right ventricular overload causes the decrease in cardiac output after nitric oxide synthesis inhibition in endotoxemia.
ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase.
Selective inhibition of endothelium-dependent vasodilator capacity by Escherichia coli endotoxemia.
Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia.
Selective versus non-selective suppression of nitric oxide synthase on regional hemodynamics in rats with or without LPS-induced endotoxemia.
Supercritical extract of Seabuckthorn Leaves (SCE200ET) inhibited endotoxemia by reducing inflammatory cytokines and nitric oxide synthase 2 expression.
The NO donor sodium nitroprusside reverses the negative effects on hepatic arterial flow induced by endotoxin and the NO synthase inhibitor L-NAME.
The pulmonary effect of nitric oxide synthase inhibition following endotoxemia in a swine model.
Use of selective and nonselective nitric oxide synthase inhibitors in rat endotoxemia: effects on hepatic morphology and function.
Ventilatory response to hypoxia during endotoxemia in young rats: role of nitric oxide.
Enterocolitis
Bowel dysfunction following pullthrough surgery is associated with an overabundance of nitrergic neurons in Hirschsprung disease.
Enterocolitis, Necrotizing
Effects of nitric oxide synthase inhibition on intestinal damage in rats with experimental necrotizing enterocolitis.
Intestinal O2 consumption in necrotizing enterocolitis: role of nitric oxide.
Low plasma concentrations of arginine and asymmetric dimethylarginine in premature infants with necrotizing enterocolitis.
Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis.
Nitric oxide synthase isoenzyme activities in a premature piglet model of necrotizing enterocolitis: effects of nitrergic manipulation.
Role of neuronal nitric oxide synthase and inducible nitric oxide synthase in intestinal injury in neonatal rats.
Enterovirus Infections
Expression of inducible nitric oxide synthase in experimental viral myocarditis.
Epilepsies, Partial
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.
Epilepsy
Anticonvulsion effect of acupuncture might be related to the decrease of neuronal and inducible nitric oxide synthases.
Effect of kainate-induced experimental epilepsy on NADPH-diaphorase and calcium-binding proteins in rat hippocampal neurons.
Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients.
Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.
Nitric oxide synthase expression in the cerebral cortex of patients with epilepsy.
Overexpression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs from frontal lobe epilepsy patients.
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.
The nitric oxide synthase inhibitor and serotonin-receptor agonist NXN-188 during the aura phase of migraine with aura: A randomized, double-blind, placebo-controlled cross-over study.
[The relation between changes of nitric oxide synthase in hippocampus and activities of excitatory amino acid receptor during epilepsy]
Epilepsy, Frontal Lobe
Overexpression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs from frontal lobe epilepsy patients.
Epilepsy, Generalized
NADPH-diaphorase-stained neurons after experimental epilepsy in rats.
Epilepsy, Reflex
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy.
Epilepsy, Temporal Lobe
Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes.
Erectile Dysfunction
Age-related changes in phosphorylation of endothelial nitric oxide synthase in the rat penis.
Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.
Classical and slow-binding inhibitors of human type II arginase.
Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction.
Dietary supplementation of tiger nut alters biochemical parameters relevant to erectile function in l-NAME treated rats.
Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats.
Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat.
Effects of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Extracts on NOS-cGMP-PDE5 Pathway in Rat Penile Smooth Muscle Cells.
Elevation of Nitric Oxide Synthase Activity by Dimethyladenosine from Silkworm Pupae in Aged Rats.
Elucidating Mechanisms of Long-Term Gasoline Vehicle Exhaust Exposure-Induced Erectile Dysfunction in a Rat Model.
Experimental Chronic Renal Failure-Associated Erectile Dysfunction: Molecular Alterations in Nitric Oxide Synthase Pathway and IGF-I System.
Gene therapy strategies for urological dysfunction.
Histopathological changes and nitric oxide synthase activity in corpus cavernosum from rats with neurogenic erectile dysfunction.
l-Arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Metformin restores the penile expression of nitric oxide synthase in high-fat-fed obese rats.
mRNA and protein expression of nitric oxide synthase and adrenoceptor alpha 1 in young and old rat penile tissues.
Nitric oxide and the endothelium: history and impact on cardiovascular disease.
Nitric oxide synthase gene therapy for cardiovascular disease.
Nitric oxide synthase gene therapy for erectile dysfunction: comparison of plasmid, adenovirus, and adenovirus-transduced myoblast vectors.
Nitric oxide synthase gene transfer for erectile dysfunction in a rat model.
Nitric oxide synthase: a new diagnostic tool for neurogenic impotence.
Off-Target Effect of Sildenafil on Postsurgical Erectile Dysfunction: Alternate Pathways and Localized Delivery System.
PDE-5 and NOS II mRNA expression in menopausal women: a molecular biology study.
Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction.
Relationship of Asymmetric Dimethylarginine With Penile Doppler Ultrasound Parameters in Men with Vasculogenic Erectile Dysfunction.
Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway.
Significance of nitric oxide and its modulation mechanisms by endogenous nitric oxide synthase inhibitors and arginase in the micturition disorders and erectile dysfunction.
Testosterone therapy in erectile dysfunction and hypogonadism.
The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men.
The distribution of nitric oxide synthase in human corpus cavernosum on various impotent patients.
Vardenafil reverses erectile dysfunction induced by paroxetine in rats.
[Expressions of NOS isoforms in the cavernous tissues of diabetic rat models]
[Nicotine reduces endogenous CO concentration and NOS activity in rat corpus cavernosum].
Erythema
Enzyme-independent nitric oxide formation during UVA challenge of human skin: characterization, molecular sources, and mechanisms.
Nitric oxide and peroxynitrite released by ultraviolet B-irradiated human endothelial cells are possibly involved in skin erythema and inflammation.
Nonenzymatic nitric oxide formation during UVA irradiation of human skin: experimental setups and ways to measure.
The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn.
Esophageal Achalasia
Abnormal internal anal sphincter innervation in patients with Hirschsprung's disease and allied disorders.
Absence of NADPH-diaphorase activity in internal anal sphincter (IAS) achalasia.
Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia.
Anti-myenteric neuronal antibodies in patients with achalasia. A prospective study.
Association between achalasia and nitric oxide synthase gene polymorphisms.
Calcium Receptor and Nitric Oxide Synthase Expression in Circular Muscle of Lower Esophagus from Patients with Achalasia.
Nitric oxide in the peripheral nervous system.
Nitric oxide synthase distribution in the enteric nervous system of children with cardiac achalasia.
Patients with achalasia lack nitric oxide synthase in the gastro-oesophageal junction.
Selective inhibition of nitric oxide synthase causes increased muscle thickness in rat esophagus.
Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia.
Esophageal and Gastric Varices
Activity of gastric mucosal nitric oxide synthase in portal hypertensive gastropathy.
Esophagitis
Effects of nitric oxide synthase inhibitor to esophagus in a feline esophagitis model.
Expression of NADPH-d in the vagal nuclei of the chronic esophagitis model in rats.
Nitric oxide and superoxide anion in low-grade esophagitis induced by acid and pepsin in rabbits.
Essential Hypertension
Alterations in nitric oxide synthase activity, superoxide anion generation, and platelet aggregation in systemic hypertension, and effects of celiprolol.
Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese.
Association analysis of TG repeat polymorphism of the neuronal nitric oxide synthase gene with essential hypertension.
Association of a variable number of tandem repeats in the endothelial constitutive nitric oxide synthase gene with essential hypertension in Japanese.
Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension.
Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease.
Examination of the role of nitric oxide synthase and renal kallikrein as candidate genes for essential hypertension.
Forearm blood flow responses to a nitric oxide synthase inhibitor in patients with treated essential hypertension.
Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension.
Impact of obesity and nitric oxide synthase gene G894T polymorphism on essential hypertension.
Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension.
Modulation of nitric oxide synthase activity in brain, liver, and blood vessels of spontaneously hypertensive rats by ascorbic acid: protection from free radical injury.
Nitric oxide dysfunction in vascular endothelium and platelets: role in essential hypertension.
Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
[Inherited defect of platelet nitric oxide synthase activity in essential hypertension]
[Linkage analysis of 13 vasoactivity-regulating short tandem genes loci in essential hypertension in Chinese]
[NOS activity in vascular smooth muscle cells of hypertension patients and the effect of AVP on NO synthesis]
[Study on the relationship between nitric oxide synthase gene G894T polymorphism and hypertension related risk factors in patients with essential hypertension in Chongqing city]
Exanthema
AQP1 and AQP3, psoriasin, and nitric oxide synthases 1-3 are inflammatory mediators in erythema toxicum neonatorum.
L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells.
Eye Infections
Effect of aminoguanidine, a nitric oxide synthase inhibitor, on ocular infection with herpes simplex virus in Balb/c mice.
Facial Nerve Injuries
The role of nitric oxide in facial motoneuronal death.
Facial Paralysis
Compression of the facial nerve caused increased nitric oxide synthase activity in the facial motor nucleus.
[Effects of L-nitroarginine on the recovery of traumatic facial paralysis]
Familial Primary Pulmonary Hypertension
Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension.
Decreased whole body endogenous nitric oxide production in patients with primary pulmonary hypertension.
Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function.
Fatty Liver
Heparin modulation on hepatic nitric oxide synthase in experimental steatohepatitis.
Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model.
Fetal Diseases
Reduction in embryonic malformations and alleviation of endoplasmic reticulum stress by nitric oxide synthase inhibition in diabetic embryopathy.
Fetal Growth Retardation
Conception and pharmacodynamic profile of drospirenone.
Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction.
Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction.
Effect of maternal NG-nitro-l-arginine administration on fetal growth and hypoxia-induced changes in newborn rats.
Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats.
Endothelin and the regulation of uteroplacental perfusion in nitric oxide synthase inhibition-induced fetal growth restriction.
Fetal growth retardation in rats may result from apoptosis: role of peroxynitrite.
Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition.
Impact of endothelin A receptor antagonist selectivity in chronic nitric oxide synthase inhibition-induced fetal growth restriction in the rat.
Inducible (type II) nitric oxide synthase in human placental villous tissue of normotensive, pre-eclamptic and intrauterine growth-restricted pregnancies.
Intrauterine growth retardation is associated with reduced activity and expression of the cationic amino acid transport systems y+/hCAT-1 and y+/hCAT-2B and lower activity of nitric oxide synthase in human umbilical vein endothelial cells.
L-arginine reverses the adverse pregnancy changes induced by nitric oxide synthase inhibition in the rat.
Long-term nitric oxide blockade in the pregnant rat: effects on blood pressure and plasma levels of endothelin-1.
Marked variation in responses to long-term nitric oxide inhibition during pregnancy in outbred rats from two different colonies.
Nitric oxide synthase activities in placental tissue from normotensive, pre-eclamptic and growth retarded pregnancies.
Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction.
Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action.
Pathophysiology of chronic nitric oxide synthase inhibition-induced fetal growth restriction in the rat.
Fetal Hypoxia
Prolonged mild fetal hypoxia up-regulates type I nitric oxide synthase expression in discrete areas of the late-gestation fetal sheep brain.
Fibrosarcoma
Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53.
Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-alpha-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain.
Potentiation of photodynamic therapy antitumor activity in mice by nitric oxide synthase inhibition is fluence rate dependent.
Food Hypersensitivity
Decrease in sensitisation rate and intestinal anaphylactic response after nitric oxide synthase inhibition in a food hypersensitivity model.
Foot Ulcer
The role of nitric oxide synthase isoforms and arginase in the pathogenesis of diabetic foot ulcers: possible modulatory effects by transforming growth factor beta 1.
Frontotemporal Dementia
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Ganglion Cysts
Distribution of nitric oxide in the nasal mucosa of the rat: a histochemical study.
Histochemical observation of nitric oxide synthase in trigeminal ganglion of rats with experimental pulpitis.
Gastritis
Gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide: down-regulation of nitric oxide synthase-2 and caspase-3 by sulglycotide.
NADPH-diaphorase in antral gastritis of childhood.
Up-regulation of endothelin-1 in gastric mucosal inflammatory responses to Helicobacter pylori Lipopolysaccharide: effect of omeprazole and sucralfate.
Gastroesophageal Reflux
[Model of gastroesophageal reflux concomitant with functional constipation in conditions of nitric oxide synthase inhibition]
Gastrointestinal Neoplasms
The role of fibronectin and nitric oxide (NO) in gastrointestinal cancers.
Gastroparesis
Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists.
Gastroschisis
Gastroschisis increases small bowel nitric oxide synthase activity.
Nitric oxide synthase inhibition prevents intestinal damage in gastroschisis: a morphological evaluation in chick embryos.
The effect on the intestines of continuous release of methylene blue from a drug delivery system: an experimental study in a chick embryo gastroschisis model.
Giant Cell Tumors
[Expression and significance of nitric oxide synthase mRNAs and proteins in giant cell tumors of bone]
Giardiasis
Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection.
Gingival Overgrowth
Immunohistochemical analysis of inducible and endothelial forms of nitric oxide synthase in cyclosporin a-induced gingival overgrowth.
Gingivitis
Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor l-NAME differently affects systemic nitric oxide formation after oral Porphyromonas gingivalis inoculation in mice.
Gitelman Syndrome
Constitutive nitric oxide synthase gene expression in Bartter's and Gitelman's syndrome and its relationship to their vascular hyporesponsiveness.
Glaucoma
Alterations of ocular nitric oxide synthase in human glaucoma.
Altered nitric oxide system in patients with open-angle glaucoma.
Aqueous humor oxidative stress proteomic levels in primary open angle glaucoma.
Association Between the Asymmetric Dimethylarginine Levels and Glaucoma Severity: A Cross-Sectional Analysis of the LIGHT Study.
Beyond intraocular pressure: neuroprotective strategies for future glaucoma therapy.
Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma.
Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.
Morphological and functional changes in experimental ocular hypertension and role of neuroprotective drugs.
Neuroprotection in Glaucoma.
Nitric oxide: a potential mediator of retinal ganglion cell damage in glaucoma.
No difference in genotype frequencies of polymorphisms of the nitric oxide pathway between Caucasian normal and high tension glaucoma patients.
Pharmacologic neuroprotection with an inhibitor of nitric oxide synthase for the treatment of glaucoma.
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Saving the nerve from glaucoma: memantine to caspaces.
The promoter of inducible nitric oxide synthase implicated in glaucoma based on genetic analysis and nuclear factor binding.
Topical application of a nitric oxide synthase inhibitor reduces intraocular pressure in rabbits with experimental glaucoma.
[Pressure influence on mRNA and protein expression of inducible nitric oxide synthase in purified retinal ganglion cells of rats]
Glaucoma, Open-Angle
Alterations of ocular nitric oxide synthase in human glaucoma.
Altered nitric oxide system in patients with open-angle glaucoma.
Aqueous humor oxidative stress proteomic levels in primary open angle glaucoma.
Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma.
Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking.
Expression of nitrotyrosine and oxidative consequences in the trabecular meshwork of patients with primary open-angle glaucoma.
Nitric oxide synthase in the human glaucomatous optic nerve head.
Reproductive factors and NOS3 variant interactions in primary open-angle glaucoma.
The Relation between Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions with Gender and Postmenopausal Hormone Use.
Glioblastoma
Cancer cell metabolism and the modulating effects of nitric oxide.
Cytochemical demonstration of nitric oxide synthase and 5' nucleotidase in human glioblastoma.
Differential expression of inducible nitric oxide synthase mRNA in human brain tumours.
Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma.
Expression of nitric oxide synthase isozymes (NOS I-III) by immunohistochemistry and DNA in situ hybridization. Correlation with macrophage presence, vascular endothelial growth factor (VEGF) and oedema volumetric data in 220 glioblastomas.
Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines.
Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere Generation.
Nitric oxide synthase activity in human glioblastoma : a histochemical study.
NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line.
Glioma
Advanced glycosylation end products induce nitric oxide synthase expression in C6 glioma cells: involvement of a p38 MAP kinase-dependent mechanism.
Cytokines regulate L-arginine-dependent cyclic GMP production in rat glial cells.
Duration of expression of inducible nitric oxide synthase in glial cells.
Effects of nitric oxide modulation on tumour blood flow and microvascular permeability in C6 glioma.
Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences.
Glioma tumourgenicity is decreased by iNOS knockout: experimental studies using the C6 striatal implantation glioma model.
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.
Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells.
Induction of nitric oxide synthase in glial cells.
Induction of nitric oxide synthase in rat C6 glioma cells.
Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration.
Leptin induces nitric oxide synthase type II in C6 glioma cells Role for nuclear factor-kappaB in hormone effect.
Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway.
Molecular changes during the genesis of human gliomas.
Nitric oxide synthase activity in human glioblastoma : a histochemical study.
Nitric oxide synthase is expressed in experimental malignant glioma and influences tumour blood flow.
Norepinephrine suppresses L-arginine uptake in rat glial cells.
NOS Expression and NO Function in Glioma and Implications for Patient Therapies.
Prolactin induction of nitric oxide synthase in rat C6 glioma cells.
Signal transduction pathways involved in protective effects of melatonin in C6 glioma cells.
The activity of oxidative enzymes in short-term explant cultures of gliomas in vitro. II. Coenzyme I and II-bound dehydrogenases and NADPH-diaphorase.
The effects of chronic nitric oxide synthase suppression on glioma pathophysiology.
The implications of nitric oxide metabolism in the treatment of glial tumors.
Glomerulonephritis
Anti-GBM glomerulonephritis in mice lacking nitric oxide synthase type 2.
Arginine metabolism in experimental glomerulonephritis: interaction between nitric oxide synthase and arginase.
Changes in inducible nitric oxide synthase expression in experimental glomerulonephritis.
Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.
Cytotoxic effect of autocrine and macrophage-derived nitric oxide on cultured rat mesangial cells.
Induction of nitric oxide synthase in rat immune complex glomerulonephritis.
Interaction between gene polymorphisms of nitric oxide synthase and renin-angiotensin system in the progression of membranous glomerulonephritis.
Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase.
Reduced nitric oxide synthase activity in rats with chronic renal disease due to glomerulonephritis.
The nitric oxide pathway in glomerulonephritis.
The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.
Glomerulonephritis, IGA
Coupled induction of iNOS and p53 upregulation in renal resident cells may be linked with apoptotic activity in the pathogenesis of progressive IgA nephropathy.
Glomerulonephritis, Membranous
Chronic inhibition of nitric oxide synthase in Heymann nephritis.
Interaction between gene polymorphisms of nitric oxide synthase and renin-angiotensin system in the progression of membranous glomerulonephritis.
Glucose Intolerance
Imeglimin prevents heart failure with preserved ejection fraction by recovering the impaired unfolded protein response in mice subjected to cardiometabolic stress.
Pioglitazone decreases asymmetric dimethylarginine (ADMA) levels in patients with impaired glucose intolerance or type 2 diabetes.
Goiter
Expression of nitric oxide synthase isoforms in the thyroid gland: evidence for a role of nitric oxide in vascular control during goiter formation.
Graft vs Host Disease
Attenuation of lethal graft-versus-host disease by inhibition of nitric oxide synthase.
Gram-Negative Bacterial Infections
Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila.
Granuloma
A role for lymphotoxin beta receptor in host defense against Mycobacterium bovis BCG infection.
Effect of nitric oxide synthase inhibition on Schistosoma japonicum egg-induced granuloma formation in the mouse liver.
IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness.
Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.
TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response.
Graves Disease
Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.
Headache Disorders
Nitric oxide synthase inhibitors for the treatment of chronic tension-type headache.
Pathophysiology of tension-type headache.
[Inhibition of nitric oxide synthase has an analgesic effect in chronic pain]
Hearing Loss, Noise-Induced
Disruption of ion-trafficking system in the cochlear spiral ligament prior to permanent hearing loss induced by exposure to intense noise: possible involvement of 4-hydroxy-2-nonenal as a mediator of oxidative stress.
Modulating central gain in tinnitus: changes in nitric oxide synthase in the ventral cochlear nucleus.
[Protection from noise-induced hearing loss by a nitric oxide synthase inhibitor and neurotrophin 3 in the guinea pig cochlea]
Hearing Loss, Sensorineural
[Effect of nitric oxide and nitric oxide synthase on sensorineural hearing loss secondary to secretory otitis media]
Heart Arrest
Cardiac arrest induces decrease of nitric oxide synthase activity and increase of free radical generation in rat brain regions.
Effect of nitric oxide synthase modulation on resuscitation success in a swine ventricular fibrillation cardiac arrest model.
Hemodynamic effects of nitric oxide synthase inhibition before and after cardiac arrest in infant piglets.
Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.
Postresuscitation changes in brain free radical-mediated processes and nitric oxide synthase activity in rats: effects of individual behavior in "emotional resonance" test.
Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice.
Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase.
Heart Defects, Congenital
eNOS correlates with mitochondrial biogenesis in hearts of congenital heart disease with cyanosis.
Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism.
Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension.
Heart Diseases
An evolutionarily ancient NO synthase (NOS) in shrimp.
Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology.
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
Down-Regulation of Porcine Heart Diaphorase Reactivity by Trimanganese Hexakis(3,5-Diisopropylsalicylate), Mn(3)(3,5-DIPS)6, and Down-Regulation of Nitric Oxide Synthase Reactivity by Mn(3)(3,5-DIPS)(6) and Cu(II)(2)(3,5-DIPS)(4).
Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease.
Negative inotropic effects of cytokines on the heart mediated by nitric oxide.
Nitric oxide synthase expression in lungs of pulmonary hypertensive patients with heart disease.
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
Role of estrogen in diastolic dysfunction.
Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling.
Heart Failure
?3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism.
A polymorphism of the endothelial nitric oxide synthase promoter is associated with an increase in autonomic imbalance in patients with congestive heart failure.
Abnormal desmopressin-induced forearm vasodilatation in patients with heart failure: dependence on nitric oxide synthase activity.
Abnormal vascular responses in human chronic cardiac failure are both endothelium dependent and endothelium independent.
Altered number of diaphorase (NOS) positive neurons in the hypothalamus of rats with heart failure.
Altered vasodilator response of coronary microvasculature in pacing-induced congestive heart failure.
Biopsy coupled to quantitative immunofluorescence: a new method to study the human vascular endothelium.
Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure.
Effect of sodium nitrite on local control of contracting skeletal muscle microvascular oxygen pressure in healthy rats.
Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression.
Effects of imidapril on NOS expression and myocardial remodelling in failing heart of Dahl salt-sensitive hypertensive rats.
Effects of nitric oxide synthase inhibition on the muscle blood flow response to exercise in rats with heart failure.
Effects of olmesartan on Apelin/APJ and Akt/endothelial nitric oxide synthase pathway in Dahl rats with end-stage heart failure.
Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure.
Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy.
Endothelin stimulates an endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine, in experimental heart failure.
Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure: role of endothelium-derived nitric oxide.
Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress.
High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level.
Impaired endothelium-dependent relaxation in large, but not small arteries in rats after coronary ligation.
Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure.
Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure.
Increased L-arginine uptake and inducible nitric oxide synthase activity in aortas of rats with heart failure.
Increased sensitivity to nitric oxide synthase inhibition in patients with heart failure: potentiation of beta-adrenergic inotropic responsiveness.
Influence of nitric oxide synthase inhibition and endothelin-1 receptor blockade on acetylcholine-induced coronary artery contraction in vitro in dilated and ischemic cardiomyopathies.
l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates ?-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy.
Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking ?3?adrenoreceptor/endothelial nitric oxide synthase pathway.
New diagnostic and therapeutic possibilities for diastolic heart failure.
Nitric oxide synthase activity in peripheral polymorphonuclear leukocytes in patients with chronic congestive heart failure.
Nitric oxide synthase II mRNA expression in cardiac tissue of patients with heart failure undergoing cardiac transplantation.
Nitric oxide synthase inhibition impairs myocardial efficiency and ventriculo-arterial matching in acute ischemic heart failure.
Overexpression myocardial inducible nitric oxide synthase exacerbates cardiac dysfunction and beta-adrenergic desensitization in experimental hypothyroidism.
Overexpression of endothelium nitric oxide synthase reverses the diminished vasorelaxation in the hindlimb vasculature in ischemic heart failure in vivo.
Oxidative stress and myocardial injury in the diabetic heart.
Oxidative stress and nitric oxide synthase in skeletal muscles of rats with post-infarction, compensated chronic heart failure.
Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting.
Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure.
Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases.
Statin therapy restores sympathovagal balance in experimental heart failure.
The effects of dietary fish oil on exercising skeletal muscle vascular and metabolic control in chronic heart failure rats.
The failing human heart does not release nitrogen oxides.
The therapeutic effect of natriuretic peptides in heart failure; differential regulation of endothelial and inducible nitric oxide synthases.
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium.
[Expression of nitric oxide synthase and its effects on heart failure]
[Study on establishing animal model of myocardial infarction of blood-stasis and Xin-qi deficiency syndrome or blood-stasis and Xin-yang deficiency syndrome type]
Heart Failure, Diastolic
The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.
HELLP Syndrome
Placental expression of nitric oxide synthase during HELLP syndrome: the correlation with maternal-fetal Doppler velocimetry.
Hematologic Neoplasms
Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies.
Hemochromatosis
Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting stenosis after myocardial infarction.
Hemoglobin C Disease
Red blood cell nitric oxide synthase activation is increased in patients with sickle cell hemoglobin C disease.
Hemoglobin SC Disease
Red blood cell nitric oxide synthase activation is increased in patients with sickle cell hemoglobin C disease.
Hepatic Encephalopathy
Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure: role of nitric oxide synthase isoforms.
Portacaval shunting and hyperammonemia stimulate the uptake of L-[3H] arginine but not of L-[3H]nitroarginine into rat brain synaptosomes.
Hepatitis
Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system.
Resveratrol attenuates lipopolysaccharide-induced hepatitis in d-galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1.
Hepatitis B, Chronic
[Nitric oxide and nitric oxide synthase in patients with chronic hepatitis B]
Hepatitis C
Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes.
Hepatitis C, Chronic
Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis.
Hepatitis E
Role of nitric oxide synthase genes in hepatitis E virus infection.
Hepatitis, Chronic
Effect of the nitric oxide donor and the nitric oxide synthase inhibitor on the liver of rats with chronic hepatitis induced by dimethylnitrosamine.
Expression of the inducible form of the nitric oxide synthase gene in the livers of mice with chronic hepatitis.
Hepatoblastoma
Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells.
Hepatopulmonary Syndrome
A severe (type II) hepatopulmonary syndrome in a patient with idiopathic portal hypertension and treatment with paroxetine.
Analysis of pulmonary heme oxygenase-1 and nitric oxide synthase alterations in experimental hepatopulmonary syndrome.
Levofloxacin decreased chest wall mechanical inhomogeneities and airway and vascular remodeling in rats with induced hepatopulmonary syndrome.
Prevention of hepatopulmonary syndrome and hyperdynamic state by pentoxifylline in cirrhotic rats.
Hernias, Diaphragmatic, Congenital
Decreased pulmonary nitric oxide synthase activity in the rat model of congenital diaphragmatic hernia.
Expression of Nitric Oxide Synthase Interacting Protein (NOSIP) is Decreased in the Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.
Pathophysiology of congenital diaphragmatic hernia. X: Localization of nitric oxide synthase in the intima of pulmonary artery trunks of lambs with surgically created congenital diaphragmatic hernia.
Herpes Simplex
Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.
Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice.
Effect of aminoguanidine, a nitric oxide synthase inhibitor, on ocular infection with herpes simplex virus in Balb/c mice.
Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication.
Gene therapeutic approaches for medullary thyroid carcinoma treatment.
Herpes simplex virus encephalitis: long-term comparative study of viral load and the expression of immunologic nitric oxide synthase in mouse brain tissue.
Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1.
The effect of herpes simplex virus-1 on nitric oxide synthase in the rat brain: the role of glucocorticoids.
Herpes Zoster
Differences in the NADPH-diaphorase positivity of the cholinergic brain stem neurons following damage of their thalamic termination field.
Nitric oxide synthase inhibition in human sperm affects sperm-oocyte fusion but not zona pellucida binding.
Relationships between NADPH diaphorase staining and neuronal, endothelial, and inducible nitric oxide synthase and cytochrome P450 reductase immunoreactivities in guinea-pig tissues.
Hirschsprung Disease
Distribution of nitric oxide synthase-containing nerves in the aganglionic intestine of mutant rats: a histochemical study.
Interstitial cells of Cajal in human colon and in Hirschsprung's disease.
Lack of expression of NADPH-diaphorase and neural cell adhesion molecule (NCAM) in colonic muscle of patients with Hirschsprung's disease.
NADPH diaphorase-containing nerve fibers and neurons in the myenteric plexus are resistant to postmortem changes: studies in Hirschsprung's disease and normal autopsy material.
NADPH-diaphorase histochemical staining of suction rectal biopsies in the diagnosis of Hirschsprung's disease and allied disorders.
NADPH-diaphorase histochemistry: a reliable test for the intraoperative diagnosis of Hirschsprung's disease.
Nitric oxide in the peripheral nervous system.
Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease.
Nitric oxide synthase is deficient in the aganglionic colon of patients with Hirschsprung's disease.
Nitric oxide-containing nerves in bowel segments of patients with Hirschsprung's disease.
The distribution and co-localization of nitric oxide synthase and vasoactive intestinal polypeptide in nerves of the colons with Hirschsprung's disease.
HIV Infections
Antioxidants in infection.
Hodgkin Disease
Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin's disease.
Holoprosencephaly
Selective Depletion of Molecularly Defined Cortical Interneurons in Human Holoprosencephaly with Severe Striatal Hypoplasia.
Huntington Disease
Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease.
Age-dependent changes in nitric oxide synthase activity and protein expression in striata of mice transgenic for the Huntington's disease mutation.
Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism.
Chronic intrastriatal L-pyroglutamate: neuropathology and neuron sparing like Huntington's disease.
Chronic intrastriatal quinolinic acid produces reversible changes in perikaryal calbindin and parvalbumin immunoreactivity.
Compartmental loss of NADPH diaphorase in the neuropil of the human striatum in Huntington's disease.
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease.
NADPH diaphorase-containing striatal or cortical neurons are resistant to apoptosis.
NADPH-diaphorase histochemistry and functional analysis of human fetal striatal brain tissue transplanted into a rodent model of Huntington's disease.
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
Neuropeptide Y in cortex and striatum. Ultrastructural distribution and coexistence with classical neurotransmitters and neuropeptides.
Nitric oxide and nitric oxide synthase in Huntington's disease.
Quinolinic acid stimulates somatostatin gene expression in cultured rat cortical neurons.
Selective sparing of a class of striatal neurons in Huntington's disease.
The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.
Hydatidiform Mole
Messenger RNA expression of endothelin-1, endothelin-A receptor and endothelial constitutive nitric oxide synthase in hydatididorm moles.
Hydrocephalus
Cerebral white matter oxidation and nitrosylation in young rodents with kaolin-induced hydrocephalus.
Hyperalgesia
A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy.
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice.
Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw.
Acute thermal hyperalgesia in the rat is produced by activation of N-methyl-D-aspartate receptors and protein kinase C and production of nitric oxide.
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
Application of nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats.
Asymmetric dimethylarginine may mediate increased heat pain threshold in experimental chronic kidney disease.
Blockade of joint inflammation and secondary hyperalgesia by L-NAME, a nitric oxide synthase inhibitor.
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model.
Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Comparison of the peripheral mediator background of heat injury- and plantar incision-induced drop of the noxious heat threshold in the rat.
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice.
Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats.
Effect of cyclooxygenase and nitric oxide synthase inhibitors on vincristine induced hyperalgesia in rats.
Effect of prolonged administration of bovine lactoferrin in neuropathic pain: involvement of opioid receptors, nitric oxide and TNF-alpha.
Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia.
Effects of selective inhibitors of neuronal nitric oxide synthase on carrageenan-induced mechanical and thermal hyperalgesia.
Evidence that spinal segmental nitric oxide mediates tachyphylaxis to peripheral local anesthetic nerve block.
Experiments with nitric oxide synthase inhibitors in spinal nerve ligated rats provide no evidence of a role for nitric oxide in neuropathic mechanical allodynia.
Expression of nitric oxide synthase type II in the spinal cord under conditions producing thermal hyperalgesia.
HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
Implication of a nitric oxide synthase mechanism in the action of substance P: L-NAME blocks thermal hyperalgesia induced by endogenous and exogenous substance P in the rat.
Increase in the number of NADPH-diaphorase-positive neurons in the lumbar dorsal root ganglia following lipopolysaccharide exposure of the sciatic nerve.
Induction of spinal NADPH-diaphorase by nerve injury is attenuated by adrenal medullary transplants.
Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-?B, Caspase-1/11, ASC, NOX, and NOS Isoforms.
Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil.
Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice.
Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse.
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2.
mRNA expression of interleukins, phospholipase A2, and nitric oxide synthase in the nerve root and dorsal root ganglion induced by autologous nucleus pulposus in the rat.
N-methyl D-aspartate induced mechanical allodynia is blocked by nitric oxide synthase and cyclooxygenase-2 inhibitors.
Nitric oxide in the rat spinal cord in Freund's adjuvant-induced hyperalgesia.
Nitric oxide involvement in the trigeminal hyperalgesia in diabetic rats.
Nitric oxide is involved in ibuprofen preemptive analgesic effect in the plantar incisional model of postsurgical pain in mice.
Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice.
Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model.
Nitric oxide modulates the hyperalgesic response to mechanical noxious stimuli in sleep-deprived rats.
Nitric oxide signaling in pain and nociceptor sensitization in the rat.
Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice.
Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat.
Pathways for the bradykinin B1 receptor-mediated diabetic hyperalgesia in mice.
Peripheral nitric oxide in carrageenan-induced inflammation.
Possible mechanism of painful radiculopathy in lumbar disc herniation.
Pre-emptive anti-hyperalgesic effect of electroacupuncture in carrageenan-induced inflammation. Role of nitric oxide.
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia.
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
Sexual dimorphism for protein kinase c epsilon signaling in a rat model of vincristine-induced painful peripheral neuropathy.
Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat.
Spinal cord NADPH-diaphorase histochemical staining but not nitric oxide synthase immunoreactivity increases following carrageenan-produced hindpaw inflammation in the rat.
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
Spinal pharmacology of tactile allodynia in diabetic rats.
Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats.
The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat.
The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat.
The role of systemic, spinal and supraspinal L-arginine-nitric oxide-cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice.
Therapeutic administration of nitric oxide synthase inhibitors reverses hyperalgesia but not inflammation in a rat model of polyarthritis.
Transient up-regulation of spinal cyclooxygenase-2 and neuronal nitric oxide synthase following surgical inflammation.
[Intrathecal injection of Sar9, Met(O2)11-substance P, neurokinin-1 receptor agonist, increases nitric oxide synthase expression and nitric oxide production in the rat spinal cord]
[MK-801 attenuates NOS expression and NO content in the spinal cord of rats with inflammatory pain]
Hyperandrogenism
Detrimental effects of hyperandrogenism on uterine functions.
Hypercholesterolemia
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans.
Detrusor Overactivity in Hyperchoelsterolemia Rats.
Effect of diet induced hypercholesterolemia and selenium supplementation on nitric oxide synthase activity.
Effects of asymmetric dimethylarginine (ADMA) infusion in humans.
Endothelial dysfunction in atherosclerosis.
Hypercholesterolemia Abrogates Sevoflurane-Induced Delayed Preconditioning Against Myocardial Infarct in Rats by Alteration of Nitric Oxide Synthase Signaling.
Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.
Hypercholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-N omega nitroarginine, by less synthesis of bile acids.
Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin.
Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction.
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
Selenium supplementation and diet induced hypercholesterolemia in the rat: changes in lipid levels, malonyldialdehyde production and the nitric oxide synthase activity.
Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.
Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease.
The effect of insufficiency of tetrahydrobiopterin on endothelial function and vasoactivity.
The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes.
The endothelium in health and disease: A discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes.
The new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism.
[Protective effect of insulin-like growth factor-1 on vascular endothelial function in hypercholesterolemia and the underlying mechanism].
Hyperemia
Acid transport through gastric mucus.
Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: impact upon post-ischemic hyperemia and the electroretinogram.
Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema.
Cholecystokinin secretagogue-induced gastroprotection: role of nitric oxide and blood flow.
Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1.
Competitive inhibition of nitric oxide synthase prevents the cortical hyperemia associated with peripheral nerve stimulation.
Cutaneous Constitutive Nitric Oxide Synthase Activation in Postural Tachycardia Syndrome with Splanchnic Hyperemia.
Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans.
Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension.
Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats.
Effect of nitric oxide synthase inhibition on postischemic cerebral hyperemia.
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation.
Effects of antiaggregant and antiinflammatory doses of aspirin on coronary hemodynamics and myocardial reactive hyperemia in conscious dogs.
Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves.
Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease.
In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound.
Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.
Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia.
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs.
Nitric oxide synthase inhibition attenuates hypoglycemic cerebral hyperemia in piglets.
Nitric oxide synthase inhibition negates bombesin-induced gastroprotection.
Nitric oxide synthase inhibitors do not alter functional hyperemia in canine skeletal muscle.
Nitric oxide synthesis couples cerebral blood flow and metabolism.
Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide.
Role of nitric oxide in PGF2 alpha-induced ocular hyperemia.
Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.
Severity of hypertension affects improved resistance artery endothelial function by angiotensin-converting enzyme inhibition.
Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice?
The contribution of nitric oxide to exercise hyperemia in the human forearm.
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Value of echocardiography for evaluation of the flow-dependent epicardial coronary vasodilation in vivo.
Hyperglycemia
Adjuvant strategies for prevention of glomerulosclerosis.
Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase.
Constitutive nitric oxide synthase (cNOS) activity in Langerhans islets from streptozotocin diabetic rats.
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
Diabetic gastroenteropathy: An underdiagnosed complication.
Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists.
Effect of chronic treatment with vitamin E on endothelial dysfunction in a type I in vivo diabetes mellitus model and in vitro.
Effect of hyperglycemia and nitric oxide synthase inhibition on heat tolerance and induction of heat shock protein 72 kDa in vivo.
Effects of nitric oxide synthase inhibitors and melatonin on the hyperglycemic response to streptozotocin in rats.
Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.
Hyperglycemia alters enzyme activity and cell number in spinal sensory ganglia.
Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells.
Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress.
Inhibitory effects of a nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), on 2-deoxy-D-glucose-induced hyperglycemia in rats.
Involvement of nitric oxide in nickel-induced hyperglycemia in rats.
Modulation of nuclear factor-?B signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice.
NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, affects the central nervous system to produce peripheral hyperglycemia in conscious rats.
The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.
Ultrastructural changes and immunohistochemical localization of nitric oxide synthase, advanced glycation end products and NF-kappa B in aorta of streptozotocin treated Mongolian gerbils.
Hyperhidrosis
Effects of chronic sympathectomy on vascular function in the human forearm.
Hyperhomocysteinemia
Asymmetric dimethylarginine, homocysteine and renal function--is there a relation?
Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients.
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.
Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction.
Thrombosis and occlusion of vascular access in hemodialyzed patients.
Hyperinsulinism
Animal models of preeclampsia.
Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.
Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice.
Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin.
Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation.
Hyperlipidemias
Effects of glucomannan/spirulina-surimi on liver oxidation and inflammation in Zucker rats fed atherogenic diets.
Relationship of Asymmetric Dimethylarginine With Penile Doppler Ultrasound Parameters in Men with Vasculogenic Erectile Dysfunction.
Hyperprolactinemia
Effects of nitric oxide synthase inhibition on diethylstilbestrol-induced hyperprolactinaemia and pituitary tumourigenesis in rats.
Hypersensitivity
Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase.
Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume.
Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group.
Different mechanisms underlie the effects of acute and long-term inhibition of nitric oxide synthases in antigen-induced pulmonary eosinophil recruitment in BALB/C mice.
Effect of in vivo nitrate tolerance on hypersensitivity to NO donors after NO-synthase blockade.
Localization of nitric oxide synthase in human nasal mucosa with nasal allergy.
Nitric oxide synthase inhibition augments acute allergic reactions in the pig airways in vivo.
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Pain-related behavior following REM sleep deprivation in the rat: influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide.
Pathobiology of neuropathic pain.
Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca(2+)-NOS pathway.
The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis.
Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury.
[Influence of Xinqin tablets on guinea-pig nasal hypersensitivity]
Hypertension
A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression.
Absence of linkage for "endothelial" nitric oxide synthase locus to blood pressure in Dahl rats.
Activation of Central Angiotensin Type 2 Receptors Suppresses Norepinephrine Excretion and Blood Pressure in Conscious Rats.
Active food ingredients production from cold pressed processing residues of Camellia oleifera and Camellia sinensis seeds for regulation of blood pressure and vascular function.
Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases.
Acute hypertension after nitric oxide synthase inhibition is mediated primarily by increased endothelin vasoconstriction.
Aliskiren in early postnatal life prevents hypertension and reduces asymmetric dimethylarginine in offspring exposed to maternal caloric restriction.
Alterations in nitric oxide synthase activity, superoxide anion generation, and platelet aggregation in systemic hypertension, and effects of celiprolol.
Alterations of nitric oxide synthase expression with aging and hypertension in rats.
Altered nitric oxide synthase 3 distribution in mesenteric arteries of hypertensive rats.
Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats.
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.
An intron 4 gene polymorphism in endothelial cell nitric oxide synthase might modulate volume-dependent hypertension in patients on hemodialysis.
Angiopoietin-1 gene therapy attenuates hypertension and target organ damage in nitric oxide synthase inhibited spontaneously hypertensive rats.
Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition.
Angiotensin converting enzyme inhibitor potentiates the hypoglycaemic effect of NG-nitro-L-arginine methyl ester (L-NAME) in rats.
Angiotensin II type 1 receptor blockade restores nitric oxide-dependent renal vascular responses in renovascular hypertension.
Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition.
Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.
Angiotensin-converting enzyme inhibitors and AT1-receptor antagonist restore nitric oxide synthase (NOS) activity and neuronal NOS expression in the adrenal glands of spontaneously hypertensive rats.
Animal models of hypertension.
Animal models of spontaneous intracerebral hemorrhage.
Antihypertensive and cardioprotective effects of pumpkin seed oil.
Antihypertensive and vasoprotective effects of Clausena lansium fruits extract in L-NAME induced hypertensive rats.
Aortic connexin43 is decreased during hypertension induced by inhibition of nitric oxide synthase.
Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging.
Apocynin Ameliorates Cadmium-Induced Hypertension Through Elevation of Endothelium Nitric Oxide Synthase.
Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats Part I: Cardiovascular and renal hemodynamic effects of Arbutus unedo in L-NAME-induced hypertensive rats.
Arterial function in mineralocorticoid-NaCl hypertension: influence of angiotensin-converting enzyme inhibition.
Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with hypertension in a Tunisian population.
Asymmetric dimethylarginine and hemodynamic regulation in middle-aged men.
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension.
Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension.
AT1 receptor expression in glomeruli from NO-deficient rats.
Attenuation in rat brain nitric oxide synthase activity in the coarctation model of hypertension.
Attenuation of hypertension, cardiomyocyte hypertrophy, and myocardial fibrosis by beta-adrenoceptor blockers in rats under long-term blockade of nitric oxide synthesis.
beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine.
Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
Blood flow regulates the development of vascular hypertrophy, smooth muscle cell proliferation, and endothelial cell nitric oxide synthase in hypertension.
Blunted vascular response to endothelin-a receptor blockade in cyclosporine-treated lung transplant recipients.
Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities.
Brain nitric oxide synthase activity in spontaneously hypertensive rats during the development of hypertension.
Brain nitric oxide synthase in hypertension.
Brain nitric oxide synthase messenger RNA in central mineralocorticoid hypertension.
Brain Stem NOS and ROS in Neural Mechanisms of Hypertension.
Captopril prevents NO-deficient hypertension and left ventricular hypertrophy without affecting nitric oxide synthase activity in rats.
Cardiac weight in hypertension induced by nitric oxide synthase blockade.
Cardiovascular effects of chronic nitric oxide synthase inhibition in genetically hypertensive rats.
Cardiovascular system of offsprings of hypertensive rats with defective nitric oxide production.
Central and peripheral mechanisms involved in hypertension induced by chronic inhibition of nitric oxide synthase in rats.
Chronic administration of adrenomedullin attenuates the hypertension and increases renal nitric oxide synthase in Dahl salt-sensitive rats.
Chronic central nervous system MC3/4R blockade attenuates hypertension induced by nitric oxide synthase inhibition but not by angiotensin II infusion.
Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.
Chronic inhibition of nitric oxide synthase induces hypertension and cardiomyocyte mitochondrial and myocardial collagen remodelling in the absence of hypertrophy.
Chronic nitric oxide inhibition with L-NAME: effects on autonomic control of the cardiovascular system.
Chronic studies on the interaction between nitric oxide and endothelin in cardiovascular and renal function.
Combination of low-dose valsartan and enalapril improves endothelial dysfunction and coronary reserve in Nomega-nitro-L-arginine methyl ester-treated spontaneously hypertensive rats.
Combination of polymorphisms in the beta2-adrenergic receptor and nitric oxide synthase 3 genes increases the risk for hypertension.
Conception and pharmacodynamic profile of drospirenone.
Contribution of nitric oxide synthase (NOS) activity in blood-brain barrier disruption and edema after acute ischemia/reperfusion in aortic coarctation-induced hypertensive rats.
Correction of hypertension by normalization of endothelial levels of fibroblast growth factor and nitric oxide synthase in spontaneously hypertensive rats.
CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant.
Critical role for copper/zinc-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.
Daily exercise normalizes the number of diaphorase (NOS) positive neurons in the hypothalamus of hypertensive rats.
Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension.
Depressed renal and vascular nitric oxide synthase expression in cyclosporine-induced hypertension.
Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.
Dietary composition as a determinant of plasma asymmetric dimethylarginine in subjects with mild hypercholesterolemia.
Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension.
Differential effects of antihypertensive drugs on renal and glomerular hemodynamics and injury in the chronic nitric-oxide-suppressed rat.
Differential regulation of kallikrein, kininogen, and kallikrein-binding protein in arterial hypertensive rats.
Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats.
Down-regulation of renal glutathione synthesis by systemic nitric oxide synthesis inhibition in spontaneously hypertensive rats.
Downregulation of neuronal nitric oxide synthase and interleukin-1beta mediates angiotensin II-dependent stimulation of sympathetic nerve activity.
Dual effect of polyphenolic compounds on cardiac Na+/K+-ATPase during development and persistence of hypertension in rats.
Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophyandGlomerulosclerosis.
Dysregulation of angiotensin II synthesis is associated with salt sensitivity in the spontaneous hypertensive rat.
Effect of aluminum on the blood-brain barrier permeability during nitric oxide-blockade-induced chronic hypertension in rats.
Effect of exercise on blood pressure in rats with chronic NOS inhibition.
Effect of exercise training on resistance arteries in rats with chronic NOS inhibition.
Effect of hypertension induced by nitric oxide synthase inhibition on structure and function of resistance arteries in the rat.
Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension.
Effect of insulin on nitric oxide synthase-like immunostaining of arteries in various organs in Zucker diabetic fatty rats.
Effect of magnesium on vascular reactivity in NOS inhibition-induced hypertension.
Effect of magnesium supplementation on blood pressure and vascular reactivity in nitric oxide synthase inhibition-induced hypertension model.
Effect of magnesium supplementation on blood rheology in NOS inhibition-induced hypertension model.
Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity.
Effect of polyphenolic compounds on the renal Na(+),K(+)-ATPase during the restoration of normotension after experimentally induced hypertension in rats.
Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
Effects of a nitric oxide synthase inhibitor on pressor response to angiotensin II in conscious rats.
Effects of asymmetric dimethylarginine (ADMA) infusion in humans.
Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression.
Effects of bulbus Fritillaria water extract on blood pressure and renal functions in the L-NAME-induced hypertensive rats.
Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system.
Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension.
Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract.
Effects of NOS inhibition on the cardiopulmonary system and brain microvascular markers after intermittent hypoxia in rats.
Effects of NOS3 Glu298Asp polymorphism on hemodynamic reactivity to stress: influences of ethnicity and obesity.
Effects of vitamin E and L-arginine on cardiopulmonary function and ascites parameters in broiler chickens reared under subnormal temperatures.
Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats.
Elevated preoperative serum asymmetrical dimethylarginine (ADMA) is associated with poor outcomes after pediatric cardiac surgery.
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt.
Endothelial function and hypertension.
Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking.
Endothelin A receptor blockade alleviates hypertension and renal lesions associated with chronic nitric oxide synthase inhibition.
Endothelin and blood pressure regulation in the female rat: studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension.
Enhanced expression of serum and glucocorticoid-inducible kinase-1 in kidneys of L-NAME-treated rats.
Enhanced vascular responsiveness to Bay K 8644 in mineralocorticoid- and N-nitro arginine-induced hypertension.
Erythropoietin administration in vivo increases vascular nitric oxide synthase expression.
Essential role of AT1A receptor in the development of 2K1C hypertension.
Evidence that reduced renal medullary nitric oxide synthase activity of dahl s rats enables small elevations of arginine vasopressin to produce sustained hypertension.
Expression of nitric oxide synthase isoforms in hypothalamo-pituitary-adrenal axis during the development of spontaneous hypertension in rats.
From sodium intake restriction to nitrate supplementation: Different measures with converging mechanistic pathways?
Functional characterization of brain mitochondrial nitric oxide synthase during hypertension and aging.
Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis.
Gene expression of brain nitric oxide synthase and soluble guanylyl cyclase in hypothalamus and medulla of two-kidney, one clip hypertensive rats.
Gene therapy for hypertension: a review of potential targets.
Genetic polymorphisms and endothelial dysfunction in patients with essential hypertension: a cross-sectional case-control study.
Glomerular profile numerical density per area and mean glomerular volume in rats submitted to nitric oxide synthase blockade.
Heme oxygenase-1 overexpression fails to attenuate hypertension when the nitric oxide synthase system is not fully operative.
High salt intake inhibits nitric oxide synthase expression and aggravates hypertension in rats with chronic renal failure.
High salt medium activates RhoA/ROCK and downregulates eNOS expression via the upregulation of ADMA.
Human cytomegalovirus infection is a novel etiology for essential hypertension.
Hydrogen sulfide defends against the cardiovascular risk of Nw-nitro-L-argininemethyl ester-induced hypertension in rats via the nitric oxide/endothelial nitric oxide synthase pathway.
Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling.
Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice.
Hypertension induced by nitric oxide synthase inhibition activates the atrial natriuretic peptide (ANP) system.
Hypertension induced by nitric oxide synthase inhibitor increases responsiveness of ventricular myocardium and aorta of rat tissue to adrenomedullin stimulation in vitro.
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells.
Hyperuricemia induces endothelial dysfunction.
Hypoadiponectinemia and endogenous nitric oxide synthase inhibitor in hypertension.
Impact of tannic acid on blood pressure, oxidative stress and urinary parameters in L-NNA-induced hypertensive rats.
Impaired vasodilation and nitric oxide synthase activity in glucocorticoid-induced hypertension.
Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.
Increase in renal medullary nitric oxide synthase activity protects from norepinephrine-induced hypertension.
Increased activity of constitutive nitric oxide synthase in cardiac endothelium in spontaneous hypertension.
Increased HO-1 expression and decreased iNOS expression in the hippocampus from adult spontaneously hypertensive rats.
Increased renal expression of nitric oxide synthase and atrial natriuretic peptide in rats with glycyrrhizic-acid-induced hypertension.
Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes.
Increased vascular endothelin-1 gene expression with unaltered nitric oxide synthase levels in fructose-induced hypertensive rats.
Inflammation and oxidative stress caused by nitric oxide synthase uncoupling might lead to left ventricular diastolic and systolic dysfunction in patients with hypertension.
Influence of dietary sodium intake on renal medullary nitric oxide synthase.
Influence of fat intake and BMI on the association of rs1799983 NOS3 polymorphism with blood pressure levels in an Iberian population.
Influence of hypertension on nitric oxide synthase expression and vascular effects of lipopolysaccharide in rat mesenteric arteries.
Inhibition of l-arginine transport in platelets by asymmetric dimethylarginine and N-monomethyl-l-arginine: effects of arterial hypertension.
Inhibition of Nitric Oxide Synthase 1 Induces Salt-Sensitive Hypertension in Nitric Oxide Synthase 1? Knockout and Wild-Type Mice.
Inhibition of nitric oxide synthase potentiates hypertension and increases mortality in traumatically brain-injured rats.
Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension.
Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats.
Interaction between cholinergic and nitrergic vasodilation: a novel mechanism of blood pressure control.
Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension.
Investigation of local ACE activity and structural alterations during development of L-NAME-induced hypertension.
Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights.
Kidneys in hypertensive rats show reduced response to nitric oxide synthase inhibition as evaluated by BOLD MRI.
L-arginine fails to protect against myocardial remodelling in L-NAME-induced hypertension.
L-arginine reverses the adverse pregnancy changes induced by nitric oxide synthase inhibition in the rat.
L-NAME-induced protein remodeling and fibrosis in the rat heart.
Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: lessons from endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice.
Lack of linkage between the endothelial nitric oxide synthase gene and hypertension.
Left ventricular adaptation to chronic pressure overload induced by inhibition of nitric oxide synthase in rats.
Lifestyle Modifications to Prevent and Control Hypertension.
Locally activated renin-angiotensin system associated with TGF-beta1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats.
Long-term nitric oxide blockade in the pregnant rat: effects on blood pressure and plasma levels of endothelin-1.
Losartan-sensitive renal damage caused by chronic NOS inhibition does not involve increased renal angiotensin II concentrations.
Loss of alpha2B-adrenoceptors increases magnitude of hypertension following nitric oxide synthase inhibition.
Lower than normal expression of brain nitric oxide synthase gene in the hypothalamus of deoxycorticosterone acetate-salt hypertensive rats.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Macula Densa Nitric Oxide Synthase 1? Protects against Salt-Sensitive Hypertension.
Marked variation in responses to long-term nitric oxide inhibition during pregnancy in outbred rats from two different colonies.
Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.
Maternal N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and prevents programmed hypertension in male offspring exposed to prenatal dexamethasone and postnatal high-fat diet.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
MCP-1 and RANTES are expressed in renal cortex of rats chronically treated with nitric oxide synthase inhibitor. Involvement in macrophage and monocyte recruitment.
Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension.
Mechanism of hypertension and proteinuria during angiogenesis inhibition: evolving role of endothelin-1.
Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction.
Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rats.
Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids.
Myocardial oxidative stress and antioxidants in hypertension as a result of nitric oxide synthase inhibition.
N(G)-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: inhibition by angiotensin II type 1 receptor antagonism.
N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats.
Nephron-Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion.
Neural mechanism of hypertension by nitric oxide synthase inhibitor in dogs.
Neural mechanism of pressor action of nitric oxide synthase inhibitor in anesthetized monkeys.
Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension.
NF-?B blockade during short-term l-NAME and salt overload strongly attenuates the late development of chronic kidney disease.
Nitric oxide affects angiotensin II pressor response: possible mechanism of attenuated pressor response during pregnancy and etiology of pregnancy-induced hypertension.
Nitric oxide deficiency in chronic renal disease.
Nitric oxide in hypertension: relationship with renal injury and left ventricular hypertrophy.
Nitric oxide in streptozotocin-induced diabetes mellitus in rats.
Nitric oxide pathway as new drug targets for refractory hypertension.
Nitric oxide synthase (NOS) single nucleotide polymorphisms are associated with coronary heart disease and hypertension in the INTERGENE study.
Nitric oxide synthase activity and renal injury in genetic hypertension.
Nitric oxide synthase activity in adrenocorticotrophin-induced hypertension in the rat.
Nitric oxide synthase activity in genetic hypertension.
Nitric oxide synthase and hypertension.
Nitric oxide synthase derangements and hypertension in kidney disease.
Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase.
Nitric oxide synthase expression in the course of lead-induced hypertension.
Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.
Nitric oxide synthase gene therapy for cardiovascular disease.
Nitric oxide synthase inhibitors and hypertension in children and adolescents.
Nitric oxide synthase inhibitors cause sustained, but reversible, hypertension and hindquarters vasoconstriction in Brattleboro rats.
Nitric oxide synthase, ADMA, SDMA, and nitric oxide activity in the paraventricular nucleus throughout the etiology of renal wrap hypertension.
No evidence for vascular remodelling during hypertension induced by chronic inhibition of nitric oxide synthase in Brattleboro rats.
Nonfatal congenital alveolar dysplasia due to abnormalities of NO synthase isoforms.
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.
Partial adherence to antihypertensive therapy fails to achieve full cardiovascular benefits in hypertensive rats.
Pattern of sympathetic vasomotor activity in a model of hypertension induced by nitric oxide synthase blockade.
Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring.
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
Pivotal role of angiotensin II receptor subtype 1A in the development of two-kidney, one-clip hypertension: study in angiotensin II receptor subtype 1A knockout mice.
Plasma adrenaline responses to long-term modification of blood pressure in normotensive rats and hypertensive rats.
Plasma asymmetric dimethylarginine and retinal vessel diameters in middle-aged men.
Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition.
Polymorphisms in Endothelial Nitric Oxide Synthase (eNOS) and Vascular Endothelial Growth Factor (VEGF) Predict Sunitinib-Induced Hypertension.
Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension.
Postobstructive regeneration of kidney is derailed when surge in renal stem cells during course of unilateral ureteral obstruction is halted.
Potassium augments vascular relaxation mediated by nitric oxide in the carotid arteries of hypertensive Dahl rats.
PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension.
Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistance.
Preglomerular sudanophilia in L-NAME hypertensive rats: involvement of endothelin.
Pressure-dependent renin release during chronic blockade of nitric oxide synthase.
Prolonged NOS inhibition in the brain elevates blood pressure in normotensive rats.
Prolonged reduction of high blood pressure with human nitric oxide synthase gene delivery.
Propolis reduces oxidative stress in l-NAME-induced hypertension rats.
Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade.
Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats.
Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.
Quinapril prevents hypertension and enhanced vascular reactivity in nitroarginine-treated rats.
Reactive oxygen species: roles in blood pressure and kidney function.
Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension.
Regulatory role of nitric oxide on the cardiac Na, K-ATPase in hypertension.
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
Relationship of Asymmetric Dimethylarginine With Penile Doppler Ultrasound Parameters in Men with Vasculogenic Erectile Dysfunction.
Renal Sodium-Glucose Cotransporter Activity and Aquaporin-2 Expression in Rat Kidney during Chronic Nitric Oxide Synthase Inhibition.
Renoprotective effects of captopril in hypertension induced by nitric oxide synthase inhibition in experimental nephritis.
Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery.
Resistance artery structure and neuroeffector mechanisms in hypertension induced by inhibition of nitric oxide synthase.
Response to hypoadiponectinemia and endogenous nitric oxide synthase inhibitor in hypertension.
Resveratrol did not alter blood pressure in rats with nitric oxide synthase-inhibited hypertension.
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Role of ANG II in hypertension produced by chronic inhibition of nitric oxide synthase in conscious rats.
Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice.
Role of endothelin-1 in hypertension induced by long-term inhibition of nitric oxide synthase.
Role of glutathione in stabilization of nitric oxide during hypertension developed by inhibition of nitric oxide synthase in the rat.
Role of kinins and nitric oxide in the antihypertrophic effect of ramipril.
ROLE OF NITRIC OXIDE AS A KEY MEDIATOR ON CARDIOVASCULAR ACTIONS OF ATRIAL NATRIURETIC PEPTIDE IN SPONTANEOUSLY HYPERTENSIVE RATS.
Role of nitric oxide in regulation of the renal medulla in normal and hypertensive kidneys.
Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet.
Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome.
Salt and nitric oxide synthase inhibition-induced hypertension: kidney dysfunction and brain anti-oxidant capacity.
Salt-sensitive hypertension resulting from nitric oxide synthase inhibition is associated with loss of regulation of angiotensin II in the rat.
Secondary endothelial dysfunction: hypertension and heart failure.
Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension.
Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
Sodium thiosulfate improves renal function and oxygenation in L-NNA-induced hypertension in rats.
Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
Spironolactone suppresses inflammation and prevents L-NAME-induced renal injury in rats.
Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.
Stimulation of endogenous nitric oxide pathway by L-arginine reduces declamp mortality and attenuates hypertension associated with aortic cross-clamp-induced hindlimb ischemia in rats.
Sub-acute effect of N(G)-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices in rats: Protective effects of Kolaviron and extract of Curcuma longa L.
Susceptibility to provoked cerebral infarction is not increased in a rat model of pharmacologically-induced hypertension despite endothelial dysfunction.
Sympathetic functions in NG-nitro-L-arginine-methyl-ester-induced hypertension: modulation by the renin-angiotensin system.
Sympathetically mediated hypertension caused by chronic inhibition of nitric oxide.
Systemic Aldosterone, But Not Angiotensin II, Plays a Pivotal Role in the Pathogenesis of Renal Injury in Chronic Nitric Oxide-Deficient Male Rats.
Taurine Ameliorates Thyroid Hypofunction and Renal Injury in L-NAME-Induced Hypertensive Rats.
The antioxidant effects of green tea reduces blood pressure and sympathoexcitation in an experimental model of hypertension.
The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men.
The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.
The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice.
The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents.
The Effects of Irisin on L-Name Induced Hypertension in Rats
The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension.
The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats.
The PAI-1 Antagonist TM5441 Attenuates L-NAME-Induced Hypertension and Vascular Senescence.
The potential role of nitric oxide in the hypertrophic growth of the left ventricle.
The relationship between constitutive nitric oxide synthase (cNOS) and pregnancy induced hypertension.
The role of endothelial nitric oxide synthase expression in the development of pulmonary hypertension in chronically hypoxic infant swine.
The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase.
Thrombosis and occlusion of vascular access in hemodialyzed patients.
Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension.
Trans-cinnamaldehyde promotes nitric oxide release via the protein kinase-B /v-Akt murine thymoma viral oncogene -endothelial nitric oxide synthase pathway to alleviate hypertension in SHR.Cg-Leprcp/NDmcr rats.
TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure.
Unchanged cardiac angiotensin II levels accompany losartan-sensitive cardiac injury due to nitric oxide synthase inhibition.
Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors.
Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility.
Vascular and Macrophage Heme Oxygenase-1 in Hypertension: A Mini-Review.
Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock.
Vascular peroxidase 1 up regulation by angiotensin II attenuates nitric oxide production through increasing asymmetrical dimethylarginine in HUVECs.
Vascular reactivity and flow-pressure curve in isolated kidneys from rats with N-nitro-L-arginine methyl ester-induced hypertension.
Vascular reactivity in mesenteric resistance arteries following chronic nitric oxide synthase inhibition in Wistar rats.
Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension.
Vitamin E alleviates renal injury, but not hypertension, during chronic nitric oxide synthase inhibition in rats.
[A study on the role of contractile and relaxant reaction of umbilical vein in vitro and local changes of nitrix oxide synthase in the pathogenesis of pregnancy induced hypertension]
[Changes of placental nitric oxide synthase in patients with pregnancy induced hypertension]
[Clonidine prevents development of hypertension in N (omega)-nitro-L-arginine-treated rats]
[Contribution of L-arginine-derived nitric oxide to the structural integrity of coronary artery and cardiac interstitium, and to the regulation of sympathetic nerve activity: assessment using a rat model produced by chronic nitric oxide inhibition]
[Effect of jiangya capsule on levels of serum nitric oxide synthase activity, malondialdehyde, plasma neuropeptide Y and homocysteine in patients with senile simple systolic hypertension]
[Effects of obstructive sleep apnea style intermittent hypoxia on endothelin-1, nitric oxide, and nitric oxide synthase in endothelium: experiment with human umbilical vein endothelial cells]
[Nitric oxide and isolated aortic contraction in a pregnant hypertension model by the inhibition of nitric oxide synthase in pregnant Wistar rats]
[NOS activity in vascular smooth muscle cells of hypertension patients and the effect of AVP on NO synthesis]
[Polymorphism of angiotensin-converting enzyme and endothelial nitric oxide synthase genes in people with arterial hypertension, left ventricular hypertrophy, and hypertrophic cardiomyopathy]
[Receptor system of brain vessels in arterial hypertension.]
[Relationship between nitric oxide synthase, endothelin and the initiation of hypertension and atherosclerosis]
[Role of nitric oxide in cholecystokinin octapeptide alleviation of tumor necrosis factor alpha induced changes in rabbit pulmonary arterial reactivity]
[Some markers of oxidative stress in hypertension induced by chronic inhibition of nitric oxide syntase]
[Study on establishing animal model of myocardial infarction of blood-stasis and Xin-qi deficiency syndrome or blood-stasis and Xin-yang deficiency syndrome type]
[Study on roles of L-arginine to nitric oxide pathway for the cardiovascular control: assessment with a new model of hypertension produced by the chronic administration of nitric oxide synthase inhibitor]
[Study on the relationship between nitric oxide synthase gene G894T polymorphism and hypertension related risk factors in patients with essential hypertension in Chongqing city]
Hypertension, Malignant
Comparison of effect of endothelin antagonism and angiotensin-converting enzyme inhibition on blood pressure and vascular structure in spontaneously hypertensive rats treated with N omega-nitro-L-arginine methyl ester. Correlation with topography of vascular endothelin-1 gene expression.
Renal nitric oxide synthase and antioxidant preservation in cyp1a1-ren-2 transgenic rats with inducible malignant hypertension.
Renal thrombotic microangiopathy in a genetic model of hypertension in mice.
Vascular structure and expression of endothelin-1 gene in L-NAME-treated spontaneously hypertensive rats.
Hypertension, Portal
A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.
Aminoguanidine reverses aortic hyporeactivity to noradrenaline in portal vein-ligated rats.
Antioxidant properties of glutamine and its role in VEGF-Akt pathways in portal hypertension gastropathy.
Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats.
Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: implications for nitric oxide production.
Effects of Sapropterin on Portal and Systemic Hemodynamics in Patients With Cirrhosis and Portal Hypertension: A Bicentric Double-Blind Placebo-Controlled Study.
Endothelial calcium-calmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats.
Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension.
Hemodynamic, renal, and endocrine effects of acute inhibition of nitric oxide synthase in compensated cirrhosis.
Hepatic and mesenteric nitric oxide synthase expression in a rat model of CCl(4)-induced cirrhosis.
Hippocampal mitochondrial dysfunction with decreased mtNOS activity in prehepatic portal hypertensive rats.
Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats.
Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: role in modulating mesenteric vascular reactivity.
Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension.
Integrin-linked kinase regulates endothelial cell nitric oxide synthase expression in hepatic sinusoidal endothelial cells.
Low NO bioavailability in CCl4 cirrhotic rat livers might result from low NO synthesis combined with decreased superoxide dismutase activity allowing superoxide-mediated NO breakdown: A comparison of two portal hypertensive rat models with healthy controls.
Nitric oxide synthase activity in portal-hypertensive and cirrhotic rats.
Nitric oxide synthase expression in the splanchnic hyposensitivity to glypressin of a hemorrhage-transfused rat model with portal hypertension.
Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats.
Portal Hypertension Triggers Local Activation of Inducible Nitric Oxide Synthase Gene in Colonic Mucosa.
Protective role of intracellular glutathione against nitric oxide-induced necrosis in rat gastric mucosal cells.
Role of aortic nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension.
Role of nitric oxide in hyporeactivity to noradrenaline of isolated aortic rings in portal hypertensive rats.
Role of nitric oxide synthase and cyclooxygenase in hyperdynamic splanchnic circulation of portal hypertension.
Salviae miltiorrhizae ameliorates cirrhosis and portal hypertension by inhibiting nitric oxide in cirrhotic rats.
Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure.
The role of nitric oxide in the inhibition of gastric epithelial proliferation in portal hypertensive rats.
The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice.
Transplantation of EPCs ameliorates vascular dysfunction and portal hypertension in CCl(4) -induced rat liver cirrhotic model.
Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension.
Tumor Necrosis Factor-Alpha Regulates Inducible Nitric Oxide Synthase Gene Expression in the Portal Hypertensive Gastric Mucosa of the Rat.
Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice.
[Differences of nitric oxide synthase expression and activity between splanchnic arterial and venous vessels of cirrhotic rats]
[Effect of herbal compound 861 on expression and activity of nitric oxide synthase in hepatic stellate cells]
[The role of nitric oxide in hyperdynamic circulation in portal hypertensive rats]
Hypertension, Pregnancy-Induced
Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibition.
Gestational hypertension plasma and human umbilical vein endothelial cells: an in vitro study.
Macula Densa NOS1? Modulates Renal Hemodynamics and Blood Pressure During Pregnancy: Role in Gestational Hypertension.
Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.
The relationship between constitutive nitric oxide synthase (cNOS) and pregnancy induced hypertension.
[A study on the role of contractile and relaxant reaction of umbilical vein in vitro and local changes of nitrix oxide synthase in the pathogenesis of pregnancy induced hypertension]
[Changes of placental nitric oxide synthase in patients with pregnancy induced hypertension]
[Ganoderma spores may regulate the levels of mitochondria-related molecular substances in hippocampus of young rats birthed by rats with gestational hypertension]
Hypertension, Pulmonary
Asymmetric dimethyl arginine and symmetric dimethyl arginine levels in infants with persistent pulmonary hypertension of the newborn.
Cardiopulmonary effects of combined nitric oxide inhibition and inhaled nitric oxide in porcine endotoxic shock.
Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung.
Decreased pulmonary nitric oxide synthase activity in the rat model of congenital diaphragmatic hernia.
Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock.
Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation, reactive oxygen species production, permeability, intercellular adhesion molecule-1, and occludin expression.
Effects of Salvia miltiorrhiza extracts on rat hypoxic pulmonary hypertension, heme oxygenase-1 and nitric oxide synthase.
Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Endothelin-1 and asymmetric dimethylarginine in children with left-to-right shunt after intracardiac repair.
Endothelin-1 is elevated in monocrotaline pulmonary hypertension.
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Expression of nitric oxide synthase isoforms (NOS II and NOS III) in adult rat lung in hyperoxic pulmonary hypertension.
Gene expressions of nitric oxide synthase and matrix metalloproteinase-2 in monocrotaline-induced pulmonary hypertension in rats after bosentan treatment.
Hyperglycemia increased the responsiveness of isolated rabbit's pulmonary arterial rings to serotonin.
Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1.
Inhibition of endogenous nitric oxide synthase potentiates nitrovasodilators in experimental pulmonary hypertension.
Iptakalim ameliorates hypoxia-impaired human endothelial colony-forming cells proliferation, migration, and angiogenesis via Akt/eNOS pathways.
L-arginine prevents reduced expression of endothelial nitric oxide synthase (NOS) in pulmonary arterioles of broilers exposed to cool temperatures.
Lack of endotoxin-induced hyporesponsiveness to U46619 in isolated neonatal porcine pulmonary but not mesenteric arteries.
Nitric oxide inhalation and nitric oxide synthase inhibitor supplement for endotoxin-induced hypotension.
Nitric oxide synthase 3 and endothelin 1 immunoreactivity in pulmonary hypertension.
Nitric oxide synthase expression in the endothelium of pulmonary arterioles in normal and pulmonary hypertensive chickens subjected to chronic hypobaric hypoxia.
Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice.
Oxidant stress from uncoupled nitric oxide synthase impairs vasodilation in fetal lambs with persistent pulmonary hypertension.
PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.
Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension.
Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone.
Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy.
Role of nitric oxide in sepsis-associated pulmonary edema.
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.
Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.
Unaltered vasoconstrictor responsiveness after iNOS inhibition in lungs from chronically hypoxic rats.
Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS.
Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension.
[A study of the effects of L-arginine in pathogenesis of hypoxic pulmonary hypertension]
[Changes of nitric oxide synthase in hypoxic pulmonary hypertension and the effect of L-arg and L-NAME on pulmonary circulation]
[Collagen expression of intra-acinar pulmonary arteries and right ventricle and intervention of Radix Astragali in rats with hypoxic pulmonary hypertension]
[Expression of endothelin-1 mRNA, endothelin receptor-A and nitric oxide synthase mRNA in pulmonary artery and right ventriculus cordis of rats exposed to hypoxia]
[Gene therapy for pulmonary hypertension]
Hypertension, Renal
Acupuncture reduces experimental renovascular hypertension through mechanisms involving nitric oxide synthases.
Attenuation in rat brain nitric oxide synthase activity in the coarctation model of hypertension.
Hypertension, Renovascular
Altered expression of angiotensin AT1a and vasopressin V1a receptors and nitric oxide synthase mRNA in the brain of rats with renovascular hypertension.
Essential role of AT1A receptor in the development of 2K1C hypertension.
Parallel regulation of constitutive NO synthase and renin at JGA of rat kidney under various stimuli.
Hyperthyroidism
Effects of coenzyme Q10 on the heart ultrastructure and nitric oxide synthase during hyperthyroidism.
Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism.
Impaired Cardiovascular Function in Male Rats with Hypo- and Hyperthyroidism: Involvement of Imbalanced Nitric Oxide Synthase Levels.
Influence of hyperthyroidism on the activity of liver nitric oxide synthase in the rat.
Nitric oxide synthase activity in hyperthyroid and hypothyroid rats.
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients.
The involvement of the pentose shunt in thyroid metabolism after stimulation with TSH or with immunoglobulins from patients with thyroid disease. II. The reoxidation of NADPH and stimulation of hormone synthesis.
Hypertriglyceridemia
Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats.
Effects of asymmetric dimethylarginine (ADMA) infusion in humans.
Hypertrophy, Left Ventricular
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.
Captopril prevents NO-deficient hypertension and left ventricular hypertrophy without affecting nitric oxide synthase activity in rats.
Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy.
Endothelial dysfunction and cardiorenal injury in experimental salt-sensitive hypertension: effects of antihypertensive therapy.
L-arginine fails to protect against myocardial remodelling in L-NAME-induced hypertension.
Role of kinins and nitric oxide in the antihypertrophic effect of ramipril.
[Hereditary factors and left ventricular hypertrophy]
[Polymorphism of angiotensin-converting enzyme and endothelial nitric oxide synthase genes in people with arterial hypertension, left ventricular hypertrophy, and hypertrophic cardiomyopathy]
Hypertrophy, Right Ventricular
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3.
[Expression of endothelin-1 mRNA, endothelin receptor-A and nitric oxide synthase mRNA in pulmonary artery and right ventriculus cordis of rats exposed to hypoxia]
Hyperventilation
Effect of nitric oxide synthase inhibition on hypercapnia-induced hypothermia and hyperventilation.
Spontaneous fluctuations in cerebral oxygen supply. An introduction.
Hypocalcemia
Studies of hypoxemic/reoxygenation injury: with aortic clamping. XIII. Interaction between oxygen tension and cardioplegic composition in limiting nitric oxide production and oxidant damage.
Hypoglycemia
Effects of estradiol on lactoprivic signaling of the hindbrain upon the contraregulatory hormonal response and metabolic neuropeptide synthesis in hypoglycemic female rats.
Ethanol acutely stimulates islet blood flow, amplifies insulin secretion, and induces hypoglycemia via nitric oxide and vagally mediated mechanisms.
Examination of potential mechanisms in the enhancement of cerebral blood flow by hypoglycemia and pharmacological doses of deoxyglucose.
Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress.
NG-methyl-L-arginine and somatostatin decrease glucose and insulin and block endothelin-1 (ET-1)-induced insulin release but not ET-1-induced hypoglycemia.
Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death.
Hypogonadism
Impact of Sleep Deprivation on the Hypothalamic-Pituitary-Gonadal Axis and Erectile Tissue.
Hypokinesia
Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Hypotension
Activation of Flk-1/KDR mediates angiogenesis but not hypotension.
Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock.
Activation of the 5-HT7 receptor but not nitric oxide synthase is necessary for chronic 5-hydroxytryptamine-induced hypotension.
An inhibitor of nitric oxide synthase, N omega-nitro-L-arginine-methyl ester, attenuates hypotension but does not improve cardiac depression in anaphylaxis in dogs.
Anesthesia with sodium pentobarbital enhances lipopolysaccharide-induced cardiovascular dysfunction in rats.
Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats.
Brain stem oxidative stress and its associated signaling in the regulation of sympathetic vasomotor tone.
Cardiovascular autonomic modulation by nitric oxide synthases accounts for the augmented enalapril-evoked hypotension in ethanol-fed female rats.
Cardiovascular effects of eugenol, a phenolic compound present in many plant essential oils, in normotensive rats.
Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock.
Design of nitric oxide synthase inhibitors and their use to reverse hypotension associated with cancer immunotherapy.
Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta.
Effect of N(G)-nitro-L-arginine methyl ester on autonomic modulation of heart rate variability during hypovolemic shock.
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock.
Effects of a nitric oxide synthase inhibitor in humans with septic shock.
Effects of adrenergic, cholinergic and ganglionic blockade on acute depressor responses to metformin in spontaneously hypertensive rats.
Effects of aminoguanidine and L-NAME on histamine-induced blood pressure drop in the rat.
Effects of hypertonic arginine on cerebral blood flow and intracranial pressure after traumatic brain injury combined with hemorrhagic hypotension.
Effects of nitric oxide synthase inhibitors on systemic hypotension, cytokines and inducible nitric oxide synthase expression and lung injury following endotoxin administration in rats.
Effects of nitro-L-arginine on blood pressure and cardiac index in anesthetized rats: a pharmacokinetic-pharmacodynamic analysis.
Endothelium-dependent vasodilation in response to Pseudomonas aeruginosa lipopolysaccharide: an in vitro study on canine arteries.
Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats.
Failure of L-nitroarginine, a nitric oxide synthase inhibitor, to affect hypotension and plasma protein extravasation produced by tachykinin NK-1 receptor activation in rats.
First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia.
HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats.
Hypotension During Septic Shock Does Not Correlate With Plasma Levels of Nitric Oxide Metabolites in the Conscious Rat.
Hypotension induces Fos immunoreactivity in NADPH-diaphorase positive neurons in the paraventricular and supraoptic hypothalamic nuclei of the rat.
Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine.
Inhibition of neuronal nitric oxide synthase activity does not alter vasopressin secretion in septic rats.
Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs.
L-NAME, a nitric oxide synthase inhibitor, as a potential countermeasure to post-suspension hypotension in rats.
Lipopolysaccharide-induced hypotension and vascular hyporeactivity in the rat: tissue analysis of nitric oxide synthase mRNA and protein expression in the presence and absence of dexamethasone, NG-monomethyl-L-arginine or indomethacin.
Low-level expression and limited role for the inducible isoform of nitric oxide synthase in the vascular hyporeactivity and mortality associated with cecal ligation and puncture in the rat.
Methylene blue and vasoplegia: who, when, and how?
Methylene blue: potential use of an antique molecule in vasoplegic syndrome during cardiac surgery.
Modification of alpha1 -adrenoceptors by peroxynitrite as a possible mechanism of systemic hypotension in sepsis.
NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, reverses interleukin-2-induced hypotension.
Nitric oxide contributes to desipramine-induced hypotension in rats.
Nitric oxide does not mediate autoregulation of retinal blood flow in newborn pig.
Nitric oxide inhalation and nitric oxide synthase inhibitor supplement for endotoxin-induced hypotension.
Nitric oxide synthase activity is increased in relation to the severity of liver dysfunction.
Nitric oxide synthase inhibition depresses the height of the cerebral blood flow-pressure autoregulation curve during moderate hypotension.
Nitric oxide: a new area in intensive care.
Pharmacokinetics and steady-state tissue distribution of L- and D-isomers of nitroarginine in rats.
Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension.
Possible involvement of neuronal nitric oxide synthase enzyme in early-phase isoflurane-induced hypotension in rats.
Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase.
Reinforcement therapy using nitric oxide synthase inhibitors against endotoxin shock in dogs.
Reversal of hypotension induced by Vibrio vulnificus lipopolysaccharide in the rat by inhibition of nitric oxide synthase.
Reversal of refractory hypotension in septic shock by inhibitor of nitric oxide synthase.
Role of endogenous nitric oxide in septic shock.
Role of heparin and nitric oxide in the cardiac and regional hemodynamic properties of protamine in conscious chronically instrumented dogs.
Role of nitric oxide in anaphylactic shock.
Role of nitric oxide in regulation of brain stem circulation during hypotension.
Role of vascular nitric oxide synthase in endotoxin shock of Propionibacterium acnes-sensitized rats.
Spontaneous fluctuations in cerebral oxygen supply. An introduction.
The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone.
The role of nitric oxide in interleukin-2 therapy induced hypotension.
The role of nitric oxide in the reversal of hemorrhagic shock by oxotremorine.
Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide.
Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats.
Hypotension, Orthostatic
Orthostatic responses to nitric oxide synthase inhibition in persons with tetraplegia.
Hypothyroidism
Effect of nitrate and L-arginine therapy on nitric oxide levels in serum, heart, and aorta of fetal hypothyroid rats.
Hypothyroidism induces selective oxidative stress in amygdala and hippocampus of rat.
The effect of 131I-induced hypothyroidism on the levels of nitric oxide (NO), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-?), total nitric oxide synthase (NOS) activity, and expression of NOS isoforms in rats.
Hypoxia, Brain
Biochemical and histochemical studies of the effects of cerebral metabolism-improving drugs on NADPH diaphorase activity in mouse brain.
Hemodilutional anemia is associated with increased cerebral neuronal nitric oxide synthase gene expression.
Hypoxia-induced Bax and Bcl-2 protein expression, caspase-9 activation, DNA fragmentation, and lipid peroxidation in mitochondria of the cerebral cortex of newborn piglets: the role of nitric oxide.
Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet.
Hypoxia-Ischemia, Brain
Comment on "Neuronal nitric oxide synthase inhibition reduces brain damage by promoting collateral recruitment" in a cerebral hypoxia-ischemia mice model.
Effects of hypoxia-ischemia and inhibition of nitric oxide synthase on cerebral energy metabolism in newborn piglets.
Nitric Oxide Synthase Inhibition as a Neuroprotective Strategy Following Hypoxic-Ischemic Encephalopathy: Evidence From Animal Studies.
Prolonged suppression of brain nitric oxide synthase activity by 7-nitroindazole protects against cerebral hypoxic-ischemic injury in neonatal rat.
Ileitis
Amelioration of chronic ileitis by nitric oxide synthase inhibition.
Anti-inflammatory agents and substance P depletion in experimental ileitis.
Inhibition of calcium-dependent nitric oxide synthase causes ileitis and leukocytosis in guinea pigs.
Neurochemical coding in the small intestine of patients with Crohn's disease.
Nitric oxide as a modulator of intestinal water and electrolyte transport.
Ileus
Evaluation of nitric oxide as an inhibitory neurotransmitter in the equine ventral colon.
Impotence, Vasculogenic
Intracavernosal injection of vascular endothelial growth factor induces nitric oxide synthase isoforms.
Infarction, Middle Cerebral Artery
Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia.
Blood-letting punctures at twelve Jing-Well points of the hand can treat cerebral ischemia in a similar manner to mannitol.
Effect of magnesium on nitric oxide synthase of neurons in cortex during early period of cerebral ischemia.
Effect of nitric oxide synthase inhibition on cerebral blood flow and injury volume during focal ischemia in cats.
Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: detection of excitatory amino acids release and hydroxyl radical formation.
Expression of endothelial nitric oxide synthase in the ischemic penumbra: relationship to expression of neuronal nitric oxide synthase and vascular endothelial growth factor.
Expression of nitric oxide synthase (NOS)-2 following permanent focal ischemia and the role of nitric oxide in infarct generation in male, female and NOS-2 gene-deficient mice.
Induction of NADPH-diaphorase activity in the rat forebrain after middle cerebral artery occlusion.
Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion.
Inhibitory role of N omega-nitro-L-arginine methyl ester (L-NAME), a potent nitric oxide synthase inhibitor, on brain malondialdehyde and conjugated diene levels during focal cerebral ischemia in rats.
Mechanisms involved in the neuroprotective activity of a nitric oxide synthase inhibitor during focal cerebral ischemia.
Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia.
Nitric oxide production during focal cerebral ischemia in rats.
The effect of nitric oxide synthase inhibition on infarct volume after reversible focal cerebral ischemia in conscious rats.
The role of nitric oxide synthase inhibition in the adverse effects of etomidate in the setting of focal cerebral ischemia in rats.
Time course of expression of three nitric oxide synthase isoforms after transient middle cerebral artery occlusion in rats.
Infections
5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice.
A critical role for inducible nitric oxide synthase in host survival following coxsackievirus B4 infection.
A polarized Th1 type immune response to Cowdria ruminantium infection is detected in immune DBA/2 mice.
Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice.
Alterations in mRNA for inducible and endothelial nitric oxide synthase and plasma nitric oxide with rejection and/or infection of allotransplanted lungs.
Alternatively activated and immunoregulatory monocytes in human filarial infections.
Amelioration of virulent Babesia bovis infection in calves by administration of the nitric oxide synthase inhibitor aminoguanidine.
Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection.
Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase.
Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome.
Asymptomatic Helicobacter pylori infection increases asymmetric dimethylarginine levels in healthy subjects.
Augmented age-associated innate immune responses contribute to negative inotropic and lusitropic effects of lipopolysaccharide and interferon gamma.
Bacterial infection induces nitric oxide synthase in human neutrophils.
Candida albicans: the estrogen target for vaginal colonization.
Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host.
Catechins containing a galloyl moiety as potential anti-HIV-1 compounds.
CCR2 signaling contributes to the differentiation of protective inflammatory dendritic cells in Leishmania braziliensis infection.
Cell-free hemoglobin is a marker of systemic inflammation in mouse models of sepsis: a Raman spectroscopic study.
Defective Nitric Oxide Production by Alveolar Macrophages during Pneumocystis Pneumonia.
Differences in cytokine response and induction of nitric oxide synthase in endotoxin-resistant and endotoxin-sensitive mice after intravenous gram-negative infection.
Dual roles of amniotic fluid nitric oxide and prostaglandin E2 in preterm labor with intra-amniotic infection.
Effect of Helicobacter pylori infection on gastric mucosal pathologic change and level of nitric oxide and nitric oxide synthase.
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro.
Effect of the injection of an extract of Ascaris suum on macrophage activation during the early phase of Mycobacterium bovis BCG infection in C57Bl/6 mice.
Effects of aminoguanidine on latent murine tuberculosis.
Effects of daily oral doses of L-arginine on coccidiosis infections in chickens.
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis.
Effects of protein calorie malnutrition on tuberculosis in mice.
Efficient 5-OP-RU-Induced Enrichment of Mucosa-Associated Invariant T Cells in the Murine Lung Does Not Enhance Control of Aerosol Mycobacterium tuberculosis Infection.
Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni.
Expression of cyclooxygenase-2 and nitric oxide synthase 2 in swine ulcerative colitis caused by Salmonella typhimurium.
Expression of inducible nitric oxide synthase in skin lesions of patients with american cutaneous leishmaniasis.
Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis.
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.
Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection.
Genetic influence on nitric oxide production during Eimeria tenella infections in chickens.
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities: Secondary Analysis of a Randomized Clinical Trial.
Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren.
Identification of a Novel Inhibitor of HRV Replication and Inflammation in Airway Epithelial Cells.
Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences.
IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.
IL-22 Promotes IFN-?-Mediated Immunity against Histoplasma capsulatum Infection.
IL-27 Negatively Regulates Tip-DC Development during Infection.
IL-4 reduces resistance of mice to Trypanosoma cruzi infection.
Immunohistochemical localization of inducible nitric oxide synthase on human fetal amnion in intra-amniotic infection.
Immunomodulation by OK-432 and calcitonin gene-related peptide (CGRP) of nitric oxide synthase (NOS) and IL-1 beta gene expression and of HSV-1 pathogenicity in mouse skin Langerhans cells (LC).
Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice.
Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide.
Importance of nitric oxide synthase in the control of infection by Bacillus anthracis.
In vivo inhibition of inducible nitric oxide and evaluation of the brain tissue damage induced by Toxocara canis larvae in experimentally infected mice.
Increased density of neurons containing NADPH diaphorase and nitric oxide synthase in the cerebral cortex of patients with HIV-1 infection and drug abuse.
Increased inducible nitric oxide synthase expression in organs is associated with a higher severity of H5N1 influenza virus infection.
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii.
Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role.
Induction of nitric oxide synthase in Anopheles stephensi by Plasmodium falciparum: mechanism of signaling and the role of parasite glycosylphosphatidylinositols.
Induction of nitric oxide synthase with urinary tract infections.
Infection-responsive expansion of the hematopoietic stem and progenitor cell compartment in zebrafish is dependent upon inducible nitric oxide.
Influence of the ward colon tumor on the innate and endotoxin-induced inflammatory response of the rat.
Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone.
Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.
Innate immune responses of epididymal epithelial cells to Staphylococcus aureus infection.
Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection.
Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice.
Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis.
Interleukin-12-dependent mechanisms in the clearance of blood-stage murine malaria parasite Plasmodium berghei XAT, an attenuated variant of P. berghei NK65.
Involvement of p38 MAPK-dependent activator protein (AP-1) activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori by ghrelin.
Lethal Mycobacterium bovis Bacillus Calmette Guérin infection in nitric oxide synthase 2-deficient mice: cell-mediated immunity requires nitric oxide synthase 2.
Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways.
Liver infiltrating T lymphocytes express interferon gamma and inducible nitric oxide synthase in chronic hepatitis C virus infection.
Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection.
Macrophages expressing arginase 1 and nitric oxide synthase 2 accumulate in the small intestine during Giardia lamblia infection.
Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression.
Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection.
Midgut immune responses induced by bacterial infection in the silkworm, Bombyx mori.
Multitracer stable isotope quantification of arginase and nitric oxide synthase activity in a mouse model of pseudomonas lung infection.
Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection.
Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation.
NADPH diaphorase staining suggests a transient and localized contribution of nitric oxide to host defence against an intracellular pathogen in situ.
Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.
Neural circuitry of the kidney: NO-containing neurons.
Nitrate-reducing bacteria in diversion colitis: a clue to inflammation?
Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection.
Nitric oxide generation by peripheral blood cells in chronic renal failure.
Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria.
Nitric oxide participates in the toxicity of Bacillus thuringiensis Cry1Ab toxin to kill Manduca sexta larvae.
Nitric oxide produced by periostial hemocytes modulates the bacterial infection-induced reduction of the mosquito heart rate.
Nitric oxide production during Eimeria tenella infections in chickens.
Nitric oxide production is increased during murine vaccinia virus infection, but may not be essential for virus clearance.
Nitric oxide regulates MIP-1alpha expression in primary macrophages and T lymphocytes: implications for anti-HIV-1 response.
Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice.
Nitric oxide synthase and oxidative-nitrosative stress play a key role in placental infection by Trypanosoma cruzi.
Nitric oxide synthase induction with renal transplant rejection or infection.
Nitric oxide-mediated suppression of T cell responses during Trypanosoma brucei infection: soluble trypanosome products and interferon-gamma are synergistic inducers of nitric oxide synthase.
OmpA is the critical component for Escherichia coli invasion-induced astrocyte activation.
Parasite-induced Changes in Nitric Oxide levels in Drosophila paramelanica.
Pathophysiology of visceral leishmaniasis - some recent concepts.
Pretreatment with recombinant Flt3 ligand partially protects against progressive cutaneous leishmaniasis in susceptible BALB/c mice.
Profiling of jejunum inflammatory gene expression during murine eimeriosis.
Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection.
Protective role of intracellular glutathione against nitric oxide-induced necrosis in rat gastric mucosal cells.
Pseudorabies virus induces a rapid up-regulation of nitric oxide synthases in the nervous system of swine.
PTP1B negatively regulates STAT1-independent Pseudomonas aeruginosa killing by macrophages.
Quantitative and morphometric changes of subpopulations of myenteric neurons in swines with toxoplasmosis.
Quantitative real-time PCR analysis of Anopheles dirus TEP1 and NOS during Plasmodium berghei infection, using three reference genes.
Recombinant OmpA protein fragments mediate interleukin-17 regulation to prevent Escherichia coli meningitis.
Regional changes in constitutive, but not inducible NOS expression in the brains of mice infected with the LP-BM5 leukemia virus.
Regulation of Chemokines, CCL3 and CCL4, by Interferon ? and Nitric Oxide Synthase 2 in Mouse Macrophages and During Salmonella enterica Serovar Typhimurium Infection.
Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP.
Relationship of tumor necrosis factor alpha, the nitric oxide synthase pathway, and lipopolysaccharide to the killing of gamma interferon-treated macrophage-like RAW264.7 cells by Rickettsia prowazekii.
Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages.
Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo.
Role of chronic Helicobacter pylori infection in hyperdynamic circulation of cirrhotic patients.
Role of nasal nitric oxide in the resolution of experimental rhinovirus infection.
Role of nitric oxide synthase genes in hepatitis E virus infection.
Role of nitric oxide synthase type 2 in acute infection with murine cytomegalovirus.
Role of oxidative stress in infectious diseases. A review.
Role of superoxide and reactive nitrogen intermediates in Rhodnius prolixus (Reduviidae)/Trypanosoma rangeli interactions.
Serum nitrite plus nitrate in infection with human immunodeficiency virus type-1.
Simian virus 40 infection down-regulates the expression of nitric oxide synthase in human mesothelial cells.
Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.
Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells.
Studies on nitric oxide synthase activity in haemocytes of shrimps Fenneropenaeus chinensis and Marsupenaeus japonicus after white spot syndrome virus infection.
Supplementation with Abscisic Acid Reduces Malaria Disease Severity and Parasite Transmission.
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients.
Thaxtomin biosynthesis: the path to plant pathogenicity in the genus Streptomyces.
The effect of Channa striata extract and standard eradication regimen on asymmetric dimethylarginine in Helicobacter pylori gastritis rat model.
The STAT pathway mediates late-phase immunity against Plasmodium in the mosquito Anopheles gambiae.
Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages.
Toxoplasma gondii: identification of a putative nitric oxide synthase motif DNA sequence.
Transient block of respiratory chain by cyanide triggers NADPH-diaphorase activity (a marker for nitric oxide synthase) in Dunning rat prostatic epithelium.
Trypanosoma cruzi Infection Induces Myocardial Nitric Oxide Synthase.
Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice.
Type 1 interferon (IFNalpha/beta) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite.
Type 2 nitric oxide synthase and protein nitration in chronic lung infection.
Unimpaired clearance of Mycobacterium bovis BCG infection in selectively T-cell anergic TCR-V beta 8.2 transgenic mice.
Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections.
Infertility
Prolonged gonadotropin-releasing hormone agonist therapy reduced expression of nitric oxide synthase in the endometrium of women with endometriosis and infertility.
[Influences of gonadotropin releasing hormone agonist treatment on nitric oxide synthase expression in women with endometriosis and infertility]
[Relationship of nitric oxide and nitric oxide synthase with varicocele infertility]
Infertility, Female
Immunohistochemical localization of endothelial nitric oxide synthase in endometrial tissue of women with unexplained infertility.
Infertility, Male
Expression of NOS isoforms in internal spermatic veins of infertile men with varicocele.
Genetic variants in nitric oxide synthase genes and the risk of male infertility in a Chinese population: a case-control study.
Inflammatory Bowel Diseases
Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment.
Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors.
Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model.
Nitric oxide and chronic gut inflammation: controversies in inflammatory bowel disease.
Potentiation of cytokine induced iNOS expression in the human intestinal epithelial cell line, DLD-1, by cyclic AMP.
Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: influence of cell differentiation.
Influenza, Human
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.
Insulin Resistance
A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis.
Anti-inflammatory and angiogenic effects of exercise training in cardiac muscle of diabetic mice.
Apelin?13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high?fat diet.
Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance.
Asymmetric dimethylarginine: a molecule responsible for the coexistence of insulin resistance and atherosclerosis via dual nitric oxide synthase inhibition.
Blockade of hepatic nitric oxide synthase causes insulin resistance.
Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action.
Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians.
Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3.
Effects of asymmetric dimethylarginine (ADMA) infusion in humans.
Effects of cardiovascular angiotensin II type 1 receptor blockade on nitric oxide synthase inhibition in patients with insulin resistance syndrome.
Effects of central administration of insulin or l-NMMA on rat skeletal muscle microvascular perfusion.
Effects of Insulin on the Vasculature.
Elevated plasma asymmetric dimethylarginine as a marker of cardiovascular morbidity in early diabetic nephropathy in type 1 diabetes.
Endothelial nitric oxide production and insulin sensitivity. A physiological link with implications for pathogenesis of cardiovascular disease.
Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: Role of Ca(2+)/calmodulin-activated protein kinase II.
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting.
Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake.
Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.
iNOS as a metabolic enzyme under stress conditions.
Insulin resistance caused by nitric oxide synthase inhibition.
Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
Insulin resistance, the insulin resistance syndrome, and cardiovascular disease.
Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA.
Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver.
Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation.
Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats.
Involvement of increased endogenous asymmetric dimethylarginine in the hepatic endoplasmic reticulum stress of type 2 diabetic rats.
Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.
Kininase 1 As a Preclinical Therapeutic Target for Kinin B1 Receptor in Insulin Resistance.
Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment.
Neuronal nitric oxide synthase is phosphorylated in response to insulin stimulation in skeletal muscle.
Nitric oxide synthase 3 deficiency limits adverse ventricular remodeling after pressure overload in insulin resistance.
Obesity, insulin resistance, and skeletal muscle nitric oxide synthase.
p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity.
Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients.
Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistance.
Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.
Reversal of endothelial dysfunction in aorta of streptozotocin-nicotinamide-induced type-2 diabetic rats by S-Allylcysteine.
Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.
Systemic nitric oxide synthase inhibition increases insulin sensitivity in man.
The HISS story overview: a novel hepatic neurohumoral regulation of peripheral insulin sensitivity in health and diabetes.
The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
Vascular inflammation, insulin resistance, and endothelial dysfunction in salt-sensitive hypertension: role of nuclear factor kappa B activation.
von Willebrand factor antagonizes nitric oxide synthase to promote insulin resistance during hypoxia.
[Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus].
Insulinoma
Epiandrosterone and dehydroepiandrosterone affect glucose oxidation and interleukin-1 beta effects in pancreatic islets.
Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone.
Modulation of inducible nitric oxide synthase in RINm5F cells.
Nitric oxide involvement in pancreatic beta cell apoptosis by glibenclamide.
Intervertebral Disc Displacement
Histochemical demonstration of nitric oxide in herniated lumbar discs. A clinical and animal model study.
Nitric oxide as a mediator of nucleus pulposus-induced effects on spinal nerve roots.
The IL-1? (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation.
Intestinal Obstruction
Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction.
Intestinal Polyposis
Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.
Intracranial Aneurysm
Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysmal subarachnoid hemorrhage and cerebral vasospasm.
Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase.
Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm.
Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis.
Intracranial Hypertension
The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.
Iron Deficiencies
Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration.
Iron deficiency suppresses ileal nitric oxide synthase activity.
Nitrate reductase rather than nitric oxide synthase activity is involved in 24-epibrassinolide-induced nitric oxide synthesis to improve tolerance to iron deficiency in strawberry (Fragaria × annassa) by up-regulating the ascorbate-glutathione cycle.
Iron Overload
Iron is Responsible for Production of Reactive Oxygen Species Regulating Vasopressin Expression in the Mouse Paraventricular Nucleus.
Ischemic Attack, Transient
Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1.
Ischemic Stroke
A blinded, randomized study of l-arginine in small clot embolized rabbits.
Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients.
Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.
Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke.
Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats.
MTHFR C677T, FII G20210A, FV Leiden G1691A, NOS3 intron 4 VNTR, and APOE epsilon4 gene polymorphisms are not associated with spontaneous cervical artery dissection.
Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute ischaemic stroke.
Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review.
nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription.
Oxidative and nitrosative stress in acute ischaemic stroke.
Polymorphism of Nitric Oxide Synthase 1 Affects the Clinical Phenotypes of Ischemic Stroke in Korean Population.
Predictive role of polymorphisms in interleukin-5 receptor alpha-subunit, lipoprotein lipase, integrin A2 and nitric oxide synthase genes on ischemic stroke in type 2 diabetes-An 8-year prospective cohort analysis of 1327 Chinese patients.
Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women.
The 27-bp repeat polymorphism in intron 4 of the endothelial cell nitric oxide synthase gene and ischemic stroke in a Japanese population.
The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies.
Joint Diseases
Behaviour of nitric oxide synthase isoforms in inflammatory human joint diseases: an immunohistochemical study.
Keratitis
Effect of nitric oxide synthase inhibition in experimental Pseudomonas keratitis in rabbits.
Ketosis
Diabetic ketosis activates lymphomonocyte-inducible nitric oxide synthase.
Kidney Diseases
Asymmetric dimethylarginine, race, and mortality in hemodialysis patients.
Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease.
Genetic Polymorphisms in Nitric Oxide Synthase 3 Gene and Implications for Kidney Disease: A Meta-Analysis.
Kidney disease as an independent risk factor for cardiovascular events.
Nitric oxide synthase derangements and hypertension in kidney disease.
Kidney Failure, Chronic
Acute administration of L-arginine does not improve arterial endothelial function in chronic renal failure.
An intron 4 gene polymorphism in endothelial cell nitric oxide synthase might modulate lipid metabolism in nondiabetic patients on hemodialysis.
Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease.
Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach.
Differential regulation of nitric oxide synthase function in aorta and tail artery from 5/6 nephrectomized rats.
Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity.
Effects of nutritional status on the L-arginine-nitric oxide pathway in platelets from hemodialysis patients.
Endothelial nitric oxide synthase intron 4 polymorphism influences the progression of renal disease.
Erythrocyte nitric oxide metabolism in patients with chronic renal failure.
Evidence for association of endothelial cell nitric oxide synthase gene polymorphism with earlier progression to end-stage renal disease in a cohort of Hellens from Greece and Cyprus.
Functional Sympatholysis is Impaired in End-Stage Renal Disease.
Genetic analysis of nitric oxide and endothelin in end-stage renal disease.
High salt intake inhibits nitric oxide synthase expression and aggravates hypertension in rats with chronic renal failure.
Impact of Nitric Oxide Synthase Glu298Asp Polymorphism on the Development of End-Stage Renal Disease in Type 2 Diabetic Egyptian Patients.
Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure.
Levels of asymmetric dimethylarginine, nitric oxide and lipid peroxidation markers in patients with end-stage renal disease having peritoneal dialysis treatment.
Low dialysance of asymmetric dimethylarginine (ADMA)--in vivo and in vitro evidence of significant protein binding.
No Benefit of Hemodiafiltration over Hemodialysis in Lowering Elevated Levels of Asymmetric Dimethylarginine in ESRD Patients.
Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure.
Plasma from ESRD patients inhibits nitric oxide synthase activity in cultured human and bovine endothelial cells.
Removal of constitutive and inducible nitric oxide synthase-active compounds in a modified hemodiafiltration with on-line production of substitution fluid: the contribution of convection and diffusion.
The effect of n-3 fatty acids on levels of methylarginines in patients with end-stage renal disease.
The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.
The impact of chronic renal failure on nitric oxide synthase isoforms gene expression in the penis and pelvic ganglia of rats.
[Vascular damage in chronic renal failure. The increase of vascular nitrotyrosine and cytochines accumulation is accompanied by an increase of endothelial nitric oxide synthase (eNOS) expression]
Kidney Neoplasms
Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy.
Leg Ulcer
Expression of nitric oxide synthase isoforms and arginase in normal human skin and chronic venous leg ulcers.
Leishmaniasis
Impairment of cytochrome P(450) during Leishmaniasis: Role of nitric oxide synthase.
Metabolomic Profile of BALB/c Macrophages Infected with Leishmania amazonensis: Deciphering L-Arginine Metabolism.
The inhibition of arginase by N(omega)-hydroxy-l-arginine controls the growth of Leishmania inside macrophages.
Leishmaniasis, Cutaneous
TNF-alpha mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis.
Leishmaniasis, Visceral
Histological study of cell migration in the dermis of hamsters after immunisation with two different vaccines against visceral leishmaniasis.
Isolation of a nitric oxide synthase from the protozoan parasite, Leishmania donovani.
Leprosy
Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene in Brazilian patients with leprosy.
Leptospirosis
[Clinical significance of the activity of nitric oxide synthase in patients with leptospirosis]
Leukemia
Expression of a functional inducible nitric oxide synthase in hairy cell leukaemia and ESKOL cell line.
Interferon-gamma and interleukin-2 stimulate production of a soluble factor by L1210 and P815 tumor targets to promote macrophage activation.
Localization of the gene responsible for the op (osteopetrotic) defect in rats on chromosome 10.
Purification of an NADPH-dependent diaphorase from membrane of DMSO-induced differentiated human promyelocytic leukemia HL-60 cells.
Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations.
Target-oriented anti-implantation approaches for pregnancy interception: experiences in the rhesus monkey model.
[Nitric oxide synthase expression and multiple drug resistance in patients with acute leukemia]
Leukemia, Erythroblastic, Acute
Activation of nitric oxide synthase is involved in tamoxifen-induced apoptosis of human erythroleukemia K562 cells.
Leukemia, Hairy Cell
Expression of a functional inducible nitric oxide synthase in hairy cell leukaemia and ESKOL cell line.
Leukemia, Lymphocytic, Chronic, B-Cell
B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity.
CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant.
Leukemia, Myeloid
Cellular and plasma nitrite levels in myeloid leukemia - a pathogenetic decrease.
Leukocytosis
Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide.
Inhibition of calcium-dependent nitric oxide synthase causes ileitis and leukocytosis in guinea pigs.
Leukomalacia, Periventricular
[1400W blocks death pathway of LPS-induced activated-microglia to preOLs]
Leukostasis
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Lewy Body Disease
The nitric oxide synthase-3 codon 298 polymorphism is not associated with late-onset sporadic Alzheimer's dementia and Lewy body disease in a sample from Hungary.
Lichen Planus, Oral
Nitric oxide synthase isoenzyme expression in human oral lichen planus.
Liver Abscess, Amebic
Entamoeba histolytica: production of nitric oxide and in situ activity of NADPH diaphorase in amebic liver abscess of hamsters.
Liver Cirrhosis
Conservation of whole body nitric oxide metabolism in human alcoholic liver disease: implications for nitric oxide production.
Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats.
Expression of nitric oxide synthase isoforms in human liver cirrhosis.
Level of nitrated proteins in the plasma, platelets and liver of patients with liver cirrhosis.
Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis.
Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis.
Simvastatin Ameliorates Liver Fibrosis via Mediating Nitric Oxide Synthase in Rats with Non-Alcoholic Steatohepatitis-Related Liver Fibrosis.
Liver Cirrhosis, Biliary
Persistence of a liver metabolic zonation in extra-hepatic biliary atresia cirrhotic livers.
Splanchnic hyposensitivity to glypressin in a hemorrhage-transfused common bile duct-ligated rat model of portal hypertension: role of nitric oxide and bradykinin.
Liver Diseases
Asymmetric Di-methyl Arginine is Strongly Associated with Cognitive Dysfunction and Brain MR Spectroscopic Abnormalities in Cirrhosis.
Decreased constitutive hepatic nitric oxide synthase expression in secondary biliary fibrosis and its changes after Roux-en-Y choledocho-jejunostomy in the rat.
Dimethylarginine dimethylaminohydrolase 1 protects against high fat diet induced hepatic steatosis and insulin resistance in mice.
Hepatic Injury Correlates With Apoptosis, Regeneration, and Nitric Oxide Synthase Expression in Canine Chronic Liver Disease.
Increased nitric oxide synthesis and inducible nitric oxide synthase expression in patients with alcoholic and non-alcoholic liver cirrhosis.
iNOS as a metabolic enzyme under stress conditions.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Nitric oxide synthase activity is increased in relation to the severity of liver dysfunction.
Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistance.
Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.
The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase.
Liver Diseases, Alcoholic
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Liver Failure
The role of L-arginine in toxic liver failure: interrelation of arginase, polyamine catabolic enzymes and nitric oxide synthase.
Liver Failure, Acute
Detrimental effects of nitric oxide inhibition on hepatic encephalopathy in rats with thioacetamide-induced fulminant hepatic failure: role of nitric oxide synthase isoforms.
Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure.
Liver Neoplasms
Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer.
Lobomycosis
Detection of cytokines and nitric oxide synthase in skin lesions of Jorge Lobo's disease patients.
Lordosis
Cyclic GMP may potentiate lordosis behaviour by progesterone receptor activation.
The nitric oxide pathway participates in estrous behavior induced by progesterone and some of its ring A-reduced metabolites.
The nitric oxide pathway participates in lordosis behavior induced by central administration of leptin.
Lung Diseases
Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection.
Asymmetric dimethyl-arginine metabolism in a murine model of cigarette smoke-mediated lung inflammation.
Exhaled nitric oxide levels in alpha-1-antitrypsin PiMZ subjects.
Method development and validation for rat serum fingerprinting with CE-MS: application to ventilator-induced-lung-injury study.
Modulation of Lung Function by Increased Nitric Oxide Production.
Nitric oxide synthase activity is elevated in inflammatory lung disease in humans.
Proteomic analysis of the NOS2 interactome in human airway epithelial cells.
Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity.
Serum methylarginines and spirometry-measured lung function in older adults.
Surfactant blocks lipopolysaccharide signaling by inhibiting both NF?B and PARP activation in experimental ARDS.
[The NADPH-diaphorase activity of the bronchial epithelium in chronic lung diseases]
Lung Injury
A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice.
Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis.
Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric oxide synthase inhibitor.
Attenuation of bleomycin-induced lung fibrosis in rats by mesna.
Bubble CPAP Support after Discontinuation of Mechanical Ventilation Protects Rat Lungs with Ventilator-Induced Lung Injury.
Effects of hyperoxia on nitric oxide synthase expression, nitric oxide activity, and lung injury in rat pups.
Effects of nitric oxide synthase inhibitor on acid aspiration-induced lung injury in rats.
Effects of nitric oxide synthase inhibitors on systemic hypotension, cytokines and inducible nitric oxide synthase expression and lung injury following endotoxin administration in rats.
Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury.
Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-?/Smad signaling pathway.
Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice is Mediated via Angiopoietin 2.
Induction of nitric oxide synthase is a key determinant of progression to pulmonary injury in experimental pancreatitis.
Inhibition of cyclooxygenase and nitric oxide synthase in hypoxic vasoconstriction and oleic acid-induced lung injury.
Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury.
Is nitric oxide released in oleic acid lung injury?
Leukotoxin, 9,10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase.
Lung injury from smoke inhalation.
Lymph duct ligation during ischemia/reperfusion prevents pulmonary dysfunction in a rat model with omega-3 polyunsaturated fatty acid and glutamine.
Nitric Oxide Synthase Activity Correlates with OGG1 in Ozone-Induced Lung Injury Animal Models.
Nitric oxide synthase promotes distension-induced tracheal venular leukocyte adherence.
Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice.
O,O,S-trimethyl phosphorothioate increases Ca2+ independent nitric oxide synthase activity in the lung but decreases Ca2+/calmodulin dependent type in the cerebellum in Fischer 344 rats.
Ovariectomy aggravates hypersensitivity reactions to paclitaxel in rats.
Reperfusion Liver Injury Induces Down-Regulation of eNOS and Up-Regulation of iNOS in Lung Tissues.
The effect of composition, size, and solubility on acute pulmonary injury in rats following exposure to Mexico city ambient particulate matter samples.
[Effects of L-arginine and aminoguanidine on the endotoxin induced lung injury in rats].
[The effect of aminoguanidine, a nitric oxide synthase inhibitor, on bleomycin-induced lung injury in rats]
Lung Neoplasms
Cationic liposome-mediated nitric oxide synthase gene therapy enhances the antitumor effects of cisplatin in lung cancer.
Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer.
Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study.
Influence of chemotherapy on nitric oxide synthase, indole-amine-2,3-dioxygenase and CD124 expression in granulocytes and monocytes of non-small cell lung cancer.
Nitric oxide synthase activity in human lung cancer.
Nitric oxide synthase type 1 expression in human lung cancer and its relation to p53.
Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma.
Single nucleotide polymorphisms in NOS2A and NOS3 genes are not associated with treatment response of non-small cell lung cancer patients following the definitive radiochemotherapy.
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Treatment with the nitric oxide synthase inhibitor L-NAME provides a survival advantage in a mouse model of Kras mutation-positive, non-small cell lung cancer.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
[Association of Inorganics Accumulation with the Activation of NF-?B Signaling Pathway and the iNOS Expression of Lung Tissue in Xuanwei Lung Cancer Patients].
Lupus Erythematosus, Systemic
Increased nitric oxide production accompanied by the up-regulation of inducible nitric oxide synthase in vascular endothelium from patients with systemic lupus erythematosus.
Increased serum NG-hydroxy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity.
Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.
Lupus Nephritis
Association of the nitric oxide synthase (eNOS) gene polymorphism with increased risk for both lupus glomerulonephritis and rheumatoid arthritis in a single genetically homogeneous population.
Inducible Nitric Oxide Synthase Inhibitor SD-3651 Reduces Proteinuria in MRL/lpr Mice Deficient in the NOS2 Gene.
Lymphedema
Inflammation Precedes Fat Deposition in an Experimental Model of Lymphedema.
Lymphoma
Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats.
Differential expression of protein kinase C isoenzymes related to high nitric oxide synthase activity in a T lymphoma cell line.
Effect of hydrogen sulfide on myocardial protection in the setting of cardioplegia and cardiopulmonary bypass.
Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma.
Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin's lymphomas and multiple myeloma.
Induction of apoptosis in T lymphoma cells by long-term treatment with thyroxine involves PKC? nitration by nitric oxide synthase.
The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
Lymphoma, B-Cell
Genetic Polymorphisms in Nitric Oxide Synthase Genes Modify the Relationship between Vegetable and Fruit Intake and Risk of Non-Hodgkin Lymphoma.
Protective effect of vascular endothelial growth factor against cardiopulmonary bypass-associated acute kidney injury in beagles.
S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats.
The protective effects of propofol against CoCl2-induced HT22 cell hypoxia injury via PP2A/CAMKII?/nNOS pathway.
Lymphoma, Follicular
Genetic Polymorphisms in Nitric Oxide Synthase Genes Modify the Relationship between Vegetable and Fruit Intake and Risk of Non-Hodgkin Lymphoma.
Lymphoma, Large B-Cell, Diffuse
Genetic Polymorphisms in Nitric Oxide Synthase Genes Modify the Relationship between Vegetable and Fruit Intake and Risk of Non-Hodgkin Lymphoma.
Lymphoma, Non-Hodgkin
Genetic Polymorphisms in Nitric Oxide Synthase Genes Modify the Relationship between Vegetable and Fruit Intake and Risk of Non-Hodgkin Lymphoma.
The association between hepatitis C virus infection, genetic polymorphisms of oxidative stress genes and B-cell non-Hodgkin's lymphoma risk in Egypt.
Lymphopenia
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases.
Magnesium Deficiency
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Malaria
A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae.
Ambient temperature and dietary supplementation interact to shape mosquito vector competence for malaria.
Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene.
Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.
Immunogenic and Antioxidant Effects of a Pathogen-Associated Prenyl Pyrophosphate in Anopheles gambiae.
Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana.
Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin.
Induction of nitric oxide synthase in Anopheles stephensi by Plasmodium falciparum: mechanism of signaling and the role of parasite glycosylphosphatidylinositols.
Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.
Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection.
Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression.
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria.
Parasite killing in malaria non-vector mosquito Anopheles culicifacies species B: implication of nitric oxide synthase upregulation.
Placental malaria and pre-eclampsia through the looking glass backwards?
Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.
Prevalence of polymorphisms in glucose-6-phosphate dehydrogenase, sickle haemoglobin and nitric oxide synthase genes and their relationship with incidence of uncomplicated malaria in Iganga, Uganda.
Quantitative real-time PCR analysis of Anopheles dirus TEP1 and NOS during Plasmodium berghei infection, using three reference genes.
Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression.
The role of vitamin D in malaria.
Malaria, Cerebral
Malaria antigen and cytokine-induced production of reactive nitrogen intermediates by murine macrophages: no relevance to the development of experimental cerebral malaria.
Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria.
Malaria, Falciparum
Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene.
Malnutrition
Effect of neonatal malnutrition on expression of nitric oxide synthase enzyme, production of free radicals and in vitro viability of alveolar macrophages infected with methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
Effects of protein deprivation and re-feeding on P2X2 receptors in enteric neurons.
NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system.
NADPH-Diaphorase Containing Neurons and Biocytin-labelled Axon Terminals in the Visual Cortex of Adult Rats Malnourished During Development.
Thrombosis and occlusion of vascular access in hemodialyzed patients.
Marfan Syndrome
The Evaluation of Flow-Mediated Vasodilation in the Brachial Artery Correlates With Endothelial Dysfunction Evaluated by Nitric Oxide Synthase Metabolites in Marfan Syndrome Patients.
Mastitis
Nitric oxide production during endotoxin-induced mastitis in the cow.
Mastocytoma
Macrophage-derived superoxide is not required for nitric oxide mediated tumour cell killing by RAW 264 cells.
Meconium Aspiration Syndrome
Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs.
Mediastinal Cyst
NADPH-diaphorase positive cells in the chick and rat thymus.
Megacolon
Decreased vasoactive intestinal peptide levels and glutathione depletion in acquired megacolon.
Effect of Chagas' disease on nitric oxide-containing neurons in severely affected and unaffected intestine.
Nitric oxide production is diminished in colonic circular muscle from acquired megacolon.
Successful treatment of megacolon associated with colitis with a nitric oxide synthase inhibitor.
Megacolon, Toxic
Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon.
Melanoma
17?-Estradiol-Linked Nitro-l-arginine as Simultaneous Inducer of Apoptosis in Melanoma and Tumor-Angiogenic Vascular Endothelial Cells.
An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1.
Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.
Cancer cell metabolism and the modulating effects of nitric oxide.
Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.
Depletion of endogenous nitric oxide enhances cisplatin-induced apoptosis in a p53-dependent manner in melanoma cell lines.
Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development.
Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide.
Induction of endothelial nitric oxide synthase expression by melanoma sensitizes endothelial cells to tumor necrosis factor-driven cytotoxicity.
Inflammation drives nitric oxide synthase 2 expression by ?? T cells and affects the balance between melanoma and vitiligo associated melanoma.
Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine.
Monoclonal anti-tyrosine hydroxylase antibodies.
N-methyl-D-aspartate-induced excessive formation of nitric oxide in CHP100 neuroblastoma cells produces death of BMEL melanoma cells in co-culture.
Nitric oxide synthase 2 is involved in the pro-tumorigenic potential of ??17 T cells in melanoma.
Nitric oxide synthase activity is up-regulated in melanoma cell lines: a potential mechanism for metastases formation.
Role of Melanin Chemiexcitation in Melanoma Progression and Drug Resistance.
Memory Disorders
Anesthetic Ketamine Impairs Rats' Recall of Previous Information: The Nitric Oxide Synthase Inhibitor N-nitro-l-arginine methylester Antagonizes this Ketamine-induced Recognition Memory Deficit.
Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice.
Downregulation of the CB1-Mediated Endocannabinoid Signaling Underlies D-Galactose-Induced Memory Impairment.
Effects of phencyclidine on spatial learning and memory: nitric oxide-dependent mechanisms.
Effects of the nitric oxide synthase inhibitor L-NAME on recognition and spatial memory deficits produced by different NMDA receptor antagonists in the rat.
Nitric oxide synthase inhibitors protect cholinergic neurons against AlCl3 excitotoxicity in the rat brain.
Meningioma
Differential expression of inducible nitric oxide synthase mRNA in human brain tumours.
Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression.
Steroid hormone binding macromolecules in meningiomas. Failure to meet criteria of specific receptors.
Meningitis
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality.
Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels.
Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis.
Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat.
Meningitis, Bacterial
Brain injury in bacterial meningitis: therapeutic implications.
Meningitis, Pneumococcal
Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide.
Production of nitrite by primary rat astrocytes in response to pneumococci.
Menorrhagia
Nitric oxide synthase expression and steroid regulation in the uterus of women with menorrhagia.
Mesenteric Ischemia
Attenuated nitric oxide synthase activity and protein expression accompany intestinal ischemia/reperfusion injury in rats.
NADPH-diaphorase expression in the rat jejunum after intestinal ischemia/reperfusion.
The effects of L-NG-nitroarginine in a zymosan-induced multiple organ dysfunction syndrome model.
Metabolic Syndrome
Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.
Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology.
Blunted flow-mediated responses and diminished nitric oxide synthase expression in lymphatic thoracic ducts of a rat model of metabolic syndrome.
Effect of melatonin on blood pressure and nitric oxide generation in rats with metabolic syndrome.
Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats.
Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome.
IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative stress, and hypoxic response-induced mitochondrial loss in airway epithelial cells.
Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Obesity-Related Perivascular Adipose Tissue Damage Is Reversed by Sustained Weight Loss in the Rat.
Red wine extract decreases pro-inflammatory markers, nuclear factor-?B and inducible NOS, in experimental metabolic syndrome.
Role of nitric oxide synthase uncoupling at rostral ventrolateral medulla in redox-sensitive hypertension associated with metabolic syndrome.
Methemoglobinemia
Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.
Microvascular Angina
Nitric oxide synthase gene G298 allele Is it a marker for microvascular angina in hypertensive patients?
Migraine Disorders
Cocoa-enriched diets enhance expression of phosphatases and decrease expression of inflammatory molecules in trigeminal ganglion neurons.
Drugs targeting nitric oxide synthase for migraine treatment.
Expression of inducible nitric oxide synthase in trigeminal ganglion cells during culture.
Functional immunohistochemistry of neuropeptides and nitric oxide synthase in the nerve fibers of the supratentorial dura mater in an experimental migraine model.
Future drugs for migraine.
Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients.
Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism.
Migraine: emerging treatment options for preventive and acute attack therapy.
Modulation of nitric oxide synthase by nitric oxide donor compounds in migraine.
New Agents for Acute Treatment of Migraine: CGRP Receptor Antagonists, iNOS Inhibitors.
New targets for migraine therapy.
Nitric oxide in primary headaches.
Nitric oxide synthase inhibition in migraine.
Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks.
Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels.
No arguments for increased endothelial nitric oxide synthase activity in migraine based on peripheral biomarkers.
Preventive effects of AdR-siPTEN through the regulation of NMDA receptor NR2B subunit in trigeminal ganglia of migraine rats.
Targeted Nitric Oxide Synthase Inhibitors for Migraine.
The effect of sumatriptan on nitric oxide synthase enzyme production after iatrogenic inflammation in the brain stem of adolescent rats: A randomized, controlled, experimental study.
The nitric oxide synthase inhibitor and serotonin-receptor agonist NXN-188 during the aura phase of migraine with aura: A randomized, double-blind, placebo-controlled cross-over study.
The pathophysiology of migraine.
Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury.
Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.
[Molecular genetic findings in migraine]
[New horizons for acute and prophylactic treatments of migraine].
Migraine with Aura
The nitric oxide synthase inhibitor and serotonin-receptor agonist NXN-188 during the aura phase of migraine with aura: A randomized, double-blind, placebo-controlled cross-over study.
Migraine without Aura
Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients.
Mitochondrial Diseases
Nitric Oxide Deficiency in Mitochondrial Disorders: The Utility of Arginine and Citrulline.
The role of nitric oxide in muscle fibers with oxidative phosphorylation defects.
Mitochondrial Encephalomyopathies
Histological determination of nitric oxide synthase (NOS) and NADPH-diaphorase in ragged-red fibers from patients with mitochondrial encephalomyopathies.
Mucocutaneous Lymph Node Syndrome
Enhanced iNOS expression in leukocytes and circulating endothelial cells is associated with the progression of coronary artery lesions in acute Kawasaki disease.
Inducible and endothelial constitutive nitric oxide synthase gene polymorphisms in Kawasaki disease.
Multiple Myeloma
A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a newly established multiple myeloma severe combined immunodeficient mouse model.
Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin's lymphomas and multiple myeloma.
The role of Capon in multiple myeloma.
Multiple Sclerosis
Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.
An in Vitro Model of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis
Antisense blockade of inducible nitric oxide synthase in glial cells derived from adult SJL mice.
Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.
Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions.
Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis.
Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis lesions.
Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains.
Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis.
Myelin basic protein-primed T cells induce nitric oxide synthase in microglial cells. Implications for multiple sclerosis.
Nitric oxide synthase expression and enzymatic activity in multiple sclerosis.
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis.
No linkage or association of the nitric oxide synthase genes to multiple sclerosis.
Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.
Preliminary evidences of a NOS2A protective effect from relapsing-remitting multiple sclerosis.
Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase.
Pretreatment of astrocytes with interferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage.
Reactive nitrogen intermediates in human neuropathology: an overview.
The role of nitric oxide in multiple sclerosis.
Treatment of experimental autoimmune encephalomyelitis in rat by 1,25-dihydroxyvitamin D3 leads to early effects within the central nervous system.
Muscle Weakness
[Investigation of c-fos expression and NADPH-diaphorase activity in the spine cord and brain in the development of the neck muscle weakness in rats]
Muscular Atrophy
[Inhibitor of nitric oxide synthase on the denervated muscle atrophy]
[Stress and stress tolerance in chronic heart failure]
Muscular Diseases
Classical and slow-binding inhibitors of human type II arginase.
Nitric oxide-induced oxidative stress in autosomal recessive and dominant inclusion-body myopathies.
Muscular Dystrophies
A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice.
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Correlated NOS-Imu and myf5 expression by satellite cells in mdx mouse muscle regeneration during NOS manipulation and deflazacort treatment.
Expression of nitric oxide synthase in the spinal cord in C57BL/6J mice with congenital muscular dystrophy.
Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy.
Nitric oxide synthase in muscular dystrophies: a re-evaluation.
Nitric oxide synthase is up-regulated in muscle fibers in muscular dystrophy.
The susceptibility of muscle cells to oxidative stress is independent of nitric oxide synthase expression.
Muscular Dystrophy, Duchenne
Correlated NOS-Imu and myf5 expression by satellite cells in mdx mouse muscle regeneration during NOS manipulation and deflazacort treatment.
Fibre-related nitric oxide synthase (NOS) in Duchenne muscular dystrophy.
MicroRNAs involved in molecular circuitries relevant for the Duchenne muscular dystrophy pathogenesis are controlled by the dystrophin/nNOS pathway.
Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy.
Nitric oxide synthase I (NOS-I) is deficient in the sarcolemma of striated muscle fibers in patients with Duchenne muscular dystrophy, suggesting an association with dystrophin.
Selective loss of sarcolemmal nitric oxide synthase in Becker muscular dystrophy.
The serum nitric oxide levels in patients with Duchenne muscular dystrophy.
Myalgia
Inhibition of nitric oxide synthases prevents and reverses alpha,beta-meATP-induced neck muscle nociception in mice.
[Effect of muscle pain on c-fos expression and NADPH-diaphorase activity in the spinal cord]
Myasthenia Gravis
Muscle-derived nitric oxide synthase expression, differences associated with muscle fiber-type, and disease susceptibility in a rat model of myasthenia gravis.
Myocardial Infarction
Acute myocardial infarction in young adults: prognostic role of angiotensin-converting enzyme, angiotensin II type I receptor, apolipoprotein E, endothelial constitutive nitric oxide synthase, and glycoprotein IIIa genetic polymorphisms at medium-term follow-up.
An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning.
Association of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with myocardial infarction in Tunisian patients.
Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population.
Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction.
Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase.
August rats are more resistant to arrhythmogenic effect of myocardial ischemia and reperfusion than Wistar rats.
Brain natriuretic peptide limits myocardial infarct size dependent of nitric oxide synthase in rats.
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction.
Cardiomyocyte-specific overexpression of nitric oxide synthase 3: impact on left ventricular function and myocardial infarction.
Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.
Different effects of tirofiban and aspirin plus clopidogrel on myocardial no-reflow in a mini-swine model of acute myocardial infarction and reperfusion.
Differential expression of three types of nitric oxide synthase in both infarcted and non-infarcted left ventricles after myocardial infarction in the rat.
Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.
Enhanced cardioprotection against ischemia-reperfusion injury with combining sildenafil with low-dose atorvastatin.
Expert opinion on tilarginine in the treatment of shock.
Expression of an endothelial-type nitric oxide synthase isoform in human neutrophils: modification by tumor necrosis factor-alpha and during acute myocardial infarction.
Hypercholesterolemia Abrogates Sevoflurane-Induced Delayed Preconditioning Against Myocardial Infarct in Rats by Alteration of Nitric Oxide Synthase Signaling.
Immunohistochemistry in the identification of nitric oxide synthase isoenzymes in myocardial infarction.
In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism.
Induction of apoptosis in myocardial infarction and its possible relationship to nitric oxide synthase in macrophages.
Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure.
Inhibition of NOS2 ameliorates cardiac remodeling, improves heart function after myocardial infarction in rats.
Inhibition of Rho-kinase by fasudil restores the cardioprotection of ischemic postconditioninng in hypercholesterolemic rat heart.
Isolation and study of insulin activated nitric oxide synthase inhibitory protein in acute myocardial infarction subjects.
Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.
Low-dose celecoxib improves coronary function after acute myocardial ischaemia in rabbits.
Mechanism of the protective effect of Yulangsan flavonoid on myocardial ischemia/reperfusion injury in rats.
Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits.
Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels.
Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.
Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia-reperfusion injury in rats by activating the phosphatidylinositol 3-kinase pathway.
Protecting against ischemia-reperfusion injury: antiplatelet drugs, statins, and their potential interactions.
Protective effect of polydatin against ischemia/reperfusion injury in rat heart.
Protective Effects of Shenfu Injection against Myocardial Ischemia-Reperfusion Injury via Activation of eNOS in Rats.
Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction.
Sitagliptin prevents isoproterenol-induced myocardial infarction in rats by modulating nitric oxide synthase enzymes.
Spontaneous myocardial infarction and nitric oxide synthase.
Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.
The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans.
Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling.
Up-regulation of cardiac nitric oxide synthase 1-derived nitric oxide after myocardial infarction in senescent rats.
Myocardial Ischemia
Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice.
Extracellular Vesicle Injection Improves Myocardial Function and Increases Angiogenesis in a Swine Model of Chronic Ischemia.
Glibenclamide attenuates the antiarrhythmic effect of endotoxin with a mechanism not involving K(ATP) channels.
Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90.
Inhibition of nitric oxide synthase prevents myocardial protection by ramiprilat.
Medullary ventrolateral nitric oxide mediates the cardiac effect of electroacupuncture at "Neiguan" acupoint on acute myocardial ischemia in rats.
Plasma nitric oxide end products are increased in the ischemic canine heart.
The role of arginase and rho kinase in cardioprotection from remote ischemic perconditioning in non-diabetic and diabetic rat in vivo.
U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion.
Myocardial Reperfusion Injury
Angiotensin II inhibition during myocardial ischemia-reperfusion in dogs: effects on leukocyte infiltration, nitric oxide synthase isoenzymes activity and left ventricular ejection fraction.
Cardioselective nitric oxide synthase 3 gene transfer protects against myocardial reperfusion injury.
[Myocardial ischemic reperfusion injury affected by the isozymes of nitric oxide synthase and their gene expression: experimental study]
Myocardial Stunning
Myocardial stunning reduces the effects of nitric oxide on coronary capillary perfusion in the rabbit.
Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model.
Non-invasive technology that improves cardiac function after experimental myocardial infarction: Whole Body Periodic Acceleration (pGz).
The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning.
Myocarditis
Expression of nitric oxide synthase in a murine model of viral myocarditis induced by coxsackievirus B3.
L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes.
Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease.
Nitric oxide and murine coxsackievirus B3 myocarditis: aggravation of myocarditis by inhibition of nitric oxide synthase.
Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis.
Nitric oxide synthase in experimental autoimmune myocarditis dysfunction.
Oral administration of L-arginine prevents congestive heart failure in murine viral myocarditis.
Myoma
Nitric oxide synthesis in human nonpregnant myometrium and uterine myomas.
Myopia
Changes of nitric oxide synthase and cyclic guanosine mono-phosphate in form deprivation myopia in guinea pigs.
Differential expression of nitric oxide synthase isoforms in form-deprived chick eyes.
Effect of a nitric oxide synthase inhibitor on lens-induced myopia.
Effects of nitric oxide donors and nitric oxide synthase substrates on ciliary muscle contracted by carbachol and endothelin for possible use in myopia prevention.
Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken.
The effect of nitric oxide synthase inhibitor on form-deprivation myopia.
Upregulated expression of N-methyl-D-aspartate receptor 1 and nitric oxide synthase during form-deprivation myopia in guinea pigs.
Myositis
Changes in NADPH-diaphorase activity in the rat dorsal horn following an acute experimental myositis.
Have recent immunogenetic investigations increased our understanding of disease mechanisms in the idiopathic inflammatory myopathies?
Increase of nitric oxide synthases and nitrotyrosine in inclusion-body myositis.
NADPH-diaphorase reactivity and Fos-immunoreactivity within the ventral horn of the lumbar spinal cord of cats submitted to acute muscle inflammation induced by injection of carrageenan.
Nitric oxide production in relation to spontaneous B-cell lymphoma and myositis in SJL mice.
[NADPH-DIAPHORASE REACTIVITY IN THE VENTRAL HORN OF THE FELINE SPINAL CORD DURING ACUTE MUSCLE INFLAMMATION].
nadph dehydrogenase deficiency
Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin 2 and VEGF.
Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.
Mouse models of nitric oxide synthase deficiency.
Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy.
The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.
The serum nitric oxide levels in patients with Duchenne muscular dystrophy.
Nasal Obstruction
Different mechanisms between thromboxane A(2)- and leukotriene D(4)-induced nasal blockage in guinea pigs.
Nasal Polyps
Comparison of arginase isoform expression in patients with different subtypes of chronic rhinosinusitis.
Differential activity of nitric oxide synthase in human nasal mucosa and polyps.
Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyp epithelium.
Expression of nitric oxide synthases in primary ciliary dyskinesia.
High levels of nitric oxide synthase activity are associated with nasal polyp tissue from aspirin-sensitive asthmatics.
Increased exhaled nitric oxide and its oxidation metabolism in eosinophilic chronic rhinosinusitis.
[Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyps]
[Expression of nitric oxide synthase and its significance in nasal polyps]
[Expression of the inducible isoform of nitric oxide synthase mRNA and the role in nasal polyps]
Nasopharyngeal Carcinoma
Contribution of Nitric oxide synthase 3 genetic variants to nasopharyngeal carcinoma risk and progression in a Tunisian population.
Neonatal Sepsis
Detrimental effects of N(omega) nitro-L-arginine methyl ester (L-NAME)in experimental Escherichia coli sepsis in the newborn piglet.
Neoplasm Metastasis
Activation of nitric oxide synthase gene for inhibition of cancer metastasis.
Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma.
Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice.
Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer.
Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase.
Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.
Effect of a nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester on invasion of human colorectal cancer cell line SL-174T.
Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis.
Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.
Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism.
NG-nitro-L-arginine methyl ester inhibits bone metastasis after modified intracardiac injection of human breast cancer cells in a nude mouse model.
Nitric oxide and cancer therapy: the emperor has NO clothes.
Nitric oxide synthase activity is up-regulated in melanoma cell lines: a potential mechanism for metastases formation.
Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors.
Oedema extension in cerebral metastasis and correlation with the expression of nitric oxide synthase isozymes (NOS I-III).
Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors.
Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase.
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Neoplasms
17?-Ethynyl-androst-5-ene-3?,7?,17?-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease.
17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response.
A cohort of supporting metabolic enzymes is coinduced with nitric oxide synthase in human tumor cell lines.
A combination of tumor necrosis factor-alpha and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat.
A comparative study of the effects of whole red ginseng extract and polysaccharide and saponin fractions on influenza A (H1N1) virus infection.
A Novel and Selective p38 Mitogen-Activated Protein Kinase Inhibitor Attenuates LPS-Induced Neuroinflammation in BV2 Microglia and a Mouse Model.
A transient inflammatory reaction in the lung after experimental hemorrhagic shock and resuscitation with a hemoglobin-vesicles solution compared with rat RBC transfusion.
Activation and mitogen-activated protein kinase regulation of transcription factors Ets and NF-kappaB in Mycobacterium-infected macrophages and role of these factors in tumor necrosis factor alpha and nitric oxide synthase 2 promoter function.
Activation of nitric oxide synthase gene for inhibition of cancer metastasis.
Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies.
Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury.
Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs.
Acute Penicillium marneffei infection stimulates host M1/M2a macrophages polarization in BALB/C mice.
Adjuvant cationic liposomes presenting MPL and IL-12 induce cell death, suppress tumor growth, and alter the cellular phenotype of tumors in a murine model of breast cancer.
Aging Adversely Affects the Cigarette Smoke-induced Glutathione Adaptive Response in the Lung.
ALDH2 polymorphisms and bone mineral density in an elderly Japanese population.
All-Trans Retinoic Acid Modulates TLR4/NF-?B Signaling Pathway Targeting TNF-? and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic machinery.
Analgesic effect of total flavonoids from Sanguis draxonis on spared nerve injury rat model of neuropathic pain.
Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury.
Analysis of cytokine mRNAs in murine herpes simplex virus type 1 retinitis.
Analysis of Macrophage Activation Markers in an Experimental Model of Cutaneous Leishmaniasis Treated with Photodynamic Therapy Mediated by 5-Aminolevulinic Acid.
Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin.
Anti-inflammatory activity of 3?-hydroxycholest-5-en-7-one isolated from Hippocampus trimaculatus leach via inhibiting iNOS, TNF-?, and 1L-1? of LPS induced RAW 264.7 macrophage cells.
Anti-inflammatory Activity of ?-Carotene, Lycopene and Tri-
Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages.
Anti-Inflammatory Activity of Some Characteristic Constituents from the Vine Stems of Spatholobus suberectus.
Anti-inflammatory and angiogenic effects of exercise training in cardiac muscle of diabetic mice.
Anti-inflammatory and antinociceptive activities of bufalin in rodents.
Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice.
Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism.
Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cells.
Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites.
Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2.
Anti-inflammatory Potential of Petiveria alliacea on Activated RAW264.7 Murine Macrophages.
Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis.
Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways.
Anticoagulant from Taraxacum platycarpum.
Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats.
Antioxidant effects of N-acetylserotonin: possible mechanisms and clinical implications.
Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders.
Apelin?13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high?fat diet.
Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha.
Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors.
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Arginase I expression and activity in human mononuclear cells after injury.
Arginine and nutrition in renal disease.
Artesunate mitigates proliferation of tumor cells by alkylating heme-harboring nitric oxide synthase.
Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation.
Assessment of the expression of biomarkers of uremic inflammation in dogs with renal disease.
Association of Cigarette Smoking With Cerebrospinal Fluid Biomarkers of Neurodegeneration, Neuroinflammation, and Oxidation.
Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation.
Atractylenolide III attenuates bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation.
Atrial natriuretic peptide alleviates cardiovascular and metabolic disorders in a rat endotoxemia model: a possible role for its anti-inflammatory properties.
Attenuation of atherosclerotic complications by modulating inflammatory responses in hypercholesterolemic rats with dietary Njavara rice bran oil.
Attenuation of bleomycin-induced lung fibrosis in rats by mesna.
Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice.
Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue.
Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia.
beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality.
Biochemistry of nitric oxide.
Biomimetic nano-NOS mediated local NO release for inhibiting cancer-associated platelet activation and disrupting tumor vascular barriers.
Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers.
C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation.
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Calreticulin Transacetylase mediated activation of human platelet nitric oxide synthase by acetyl group donor compounds.
Can static electric fields increase the activity of nitric oxide synthase and induce oxidative stress and damage of spleen?
Cancer cell metabolism and the modulating effects of nitric oxide.
Candidate gene polymorphisms and risk of psoriasis: A pilot study.
Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-?-induced expression of nitric oxide synthase in dorsal root ganglion neurons.
Catechin-7-O-?-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats.
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1? S-Nitrosylation and Transcriptional Activity in Hypoxia.
CCR2 signaling contributes to the differentiation of protective inflammatory dendritic cells in Leishmania braziliensis infection.
CD40 and tumour necrosis factor-? co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages.
Cervine (Cervus elaphus) cytokine mRNA quantification by real-time polymerase chain reaction.
Changes in tumor vascular permeability in response to experimental radioimmunotherapy: a comparative study of 11 xenografts.
Characterization of estrogen-binding proteins in variants of a rat mammary tumor.
Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants.
CHEMICAL AND HISTOCHEMICAL STUDY OF THE EFFECT OF TRANSPLANTED TUMOR UPON ACTIVITY OF ADRENAL NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DIAPHORASE IN RATS.
Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.
Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase.
Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-?B-Mediated Inflammatory Pathway in Rats with Permanent Cerebral Ischemia.
Chronic peroxisome proliferator-activated receptor?/? agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.
Cigarette smoke inhibits macrophage sensing of Gram-negative bacteria and lipopolysaccharide: relative roles of nicotine and oxidant stress.
Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase.
Clinical Significance of M1/M2 Macrophages and Related Cytokines in Patients with Spinal Tuberculosis.
Cloning and functional expression of human inducible nitric oxide synthase (NOS) cDNA from a glioblastoma cell line A-172.
Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice.
Combined arginine and ascorbic acid treatment induces apoptosis in the hepatoma cell line HA22T/VGH and changes in redox status involving the pentose phosphate pathway and reactive oxygen and nitrogen species.
Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.
Comparative effect of horse gram and black gram on inflammatory mediators and antioxidant status.
Control of nitric oxide production by endogenous TNF-alpha in mouse retinal pigmented epithelial and Muller glial cells.
Coptis chinensis and Myrobalan (Terminalia chebula) Can Synergistically Inhibit Inflammatory Response In Vitro and In Vivo.
Correlation Between Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in Human Colorectal Adenocarcinoma: A Cross-Sectional Study.
Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma.
Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-?B, STAT1/3, and Akt signaling pathways.
Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages.
Cryptococcus neoformans fails to induce nitric oxide synthase in primed murine macrophage-like cells.
Cyclooxygenase and nitric oxide synthase pathways mediate the respiratory effects of TNF-? in rats.
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways.
Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism.
Cytotoxicity and Pro-/Anti-inflammatory Properties of Cinnamates, Acrylates and Methacrylates Against RAW264.7 Cells.
d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway.
Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-?B, and the induction of autophagy.
Decrease in IL-10 and increase in TNF-? levels in renal tissues during systemic inhibition of nitric oxide in anesthetized mice.
Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria.
Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Toll-like receptor agonists.
Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level.
Dendrobium nobile Alkaloids Protects against H2O2-Induced Neuronal Injury by Suppressing JAK-STATs Pathway Activation in N2A Cells.
Design of nitric oxide synthase inhibitors and their use to reverse hypotension associated with cancer immunotherapy.
Desmethylbellidifolin From Gentianella acuta Ameliorate TNBS-Induced Ulcerative Colitis Through Antispasmodic Effect and Anti-Inflammation.
Detection of inducible nitric oxide synthase (iNOS) mRNA by RT-PCR in ATL patients and HTLV-I infected cell lines: clinical features and apoptosis by NOS inhibitor.
Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide.
Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of tumor necrosis factor and interleukin-6.
Detrimental effects of a nitric oxide synthase inhibitor (N-omega-nitro-L-arginine-methyl-ester) in a murine sepsis model.
Development of a method to quantitatively monitor the effect of inhibition of nitric oxide synthase on tumour vascular activity using dynamic contrast-enhanced computed tomography.
Dexamethasone impairs pulmonary defence against Pseudomonas aeruginosa through suppressing iNOS gene expression and peroxynitrite production in mice.
Dexamethasone inhibits nitric oxide synthase mRNA induction by interleukin-1 alpha and tumor necrosis factor-alpha in vascular smooth muscle cells.
Dexmedetomidine attenuates neuropathic pain in chronic constriction injury by suppressing NR2B, NF-?B, and iNOS activation.
Diabetic ketosis activates lymphomonocyte-inducible nitric oxide synthase.
Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers.
Differential effects of monoclonal antibodies to tumor necrosis factor alpha and gamma interferon on induction of hepatic nitric oxide synthase in experimental gram-negative sepsis.
Differential effects of nitric oxide deficiency on primary tumour growth, pulmonary metastasis and prostacyclin/thromboxane A2 balance in orthotopic and intravenous murine models of 4T1 breast cancer.
Differential expression of nitric oxide synthase in human stomach cancer.
Differential expression of tumor necrosis factor ?, interleukin 1?, nuclear factor ?B in nasal mucosa among chronic rhinosinusitis patients with and without polyps.
Differential radio-adaptive responses in BALB/c and C57BL/6 mice: pivotal role of calcium and nitric oxide signalling.
Differential sensitivity of the tyrosyl radical of mouse ribonucleotide reductase to nitric oxide and peroxynitrite.
Differentially expressed lnc-NOS2P3-miR-939-5p axis in chronic heart failure inhibits myocardial and endothelial cells apoptosis via iNOS/TNF? pathway.
Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase.
Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for omega-3 fatty acids.
Does expression of inducible nitric oxide synthase correlate with severity of oral epithelial dysplasia?
Does vitreous silica contradict the toxicity of the crystalline silica paradigm?
Domoic acid-induced seizures in California sea lions (Zalophus californianus) are associated with neuroinflammatory brain injury.
Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti.
Downregulation of microglial activation by achillolide a.
Doxorubicin-induced apoptosis: implications in cardiotoxicity.
Dual Function of Nitric Oxide in Carcinogenesis, Reappraisal.
Dual regulatory effects of nitric oxide on plasminogen activator inhibitor type 1 expression in endothelial cells.
Effect of a nitric oxide synthase inhibitor and a CXC chemokine receptor-4 antagonist on tumor growth and metastasis in a xenotransplanted mouse model of adenoid cystic carcinoma of the oral floor.
Effect of acupuncture on inflammatory cytokines expression of spastic cerebral palsy rats.
Effect of alcoholic extract of aerial parts of Rosmarinus officinalis L. on pain, inflammation and apoptosis induced by chronic constriction injury (CCI) model of neuropathic pain in rats.
Effect of Anthocyanin-Rich Extract of Sour Cherry for Hyperglycemia-Induced Inflammatory Response and Impaired Endothelium-Dependent Vasodilation.
Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids.
Effect of intraperitoneally administered recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) on the cytotoxic potential of murine peritoneal cells.
Effect of mast cell granules on the gene expression of nitric oxide synthase and tumour necrosis factor-alpha in macrophages.
Effect of methylguanidine in carrageenan-induced acute inflammation in the rats.
Effect of Neuroprotective Drugs on Gene Expression in G93A/SOD1 Mice.
Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats.
Effectiveness of Atorvastatin in the Treatment of Asymptomatic Heart Failure After Myocardial Infarction: A Clinical Study.
Effects of Bacillus pumilus on growth performance, immunological indicators and gut microbiota of mice.
Effects of Berberine chloride on the liver of streptozotocin-induced diabetes in albino Wistar rats.
Effects of cytokines tumor necrosis factor alpha and interleukin 1 beta on endotoxin-mediated inhibition of endothelium-derived relaxing factor bioactivity and nitric oxide production in vascular endothelium.
Effects of glucomannan/spirulina-surimi on liver oxidation and inflammation in Zucker rats fed atherogenic diets.
Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice.
Effects of nitric oxide synthase inhibition on diethylstilbestrol-induced hyperprolactinaemia and pituitary tumourigenesis in rats.
Effects of protein calorie malnutrition on tuberculosis in mice.
Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion.
Effects of tumour necrosis factor-alpha on activity and nitric oxide synthase of endothelial progenitor cells from peripheral blood.
Efficacy of functional foods mixture in improving hypercholesterolemia, inflammatory and endothelial dysfunction biomarkers-induced by high cholesterol diet.
Electroacupuncture Pretreatment Alleviates Cerebral Ischemic Injury Through ?7 Nicotinic Acetylcholine Receptor-Mediated Phenotypic Conversion of Microglia.
Elucidation of toll-like receptor and adapter protein signaling in vascular dysfunction induced by gram-positive Staphylococcus aureus or gram-negative Escherichia coli.
Endostatin inhibits nitric oxide and diminishes VEGF and collagen XVIII in squamous carcinoma cells.
Endothelial dysfunction, nitric oxide and platelet activation in hypertensive and diabetic type II patients.
Endothelial function and dysfunction in heart failure.
Endothelial nitric oxide synthase gene polymorphism in gastric cancer.
Endothelial progenitor cells may participate in stress-induced tumour angiogenesis.
Enhanced Activity of the Macrophage M1/M2 Phenotypes and Phenotypic Switch to M1 in Periodontal Infection.
Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor.
Enhancement of bioreductive drug toxicity in murine tumours by inhibition of the activity of nitric oxide synthase.
Entamoeba histolytica modulates the nitric oxide synthase gene and nitric oxide production by macrophages for cytotoxicity against amoebae and tumour cells.
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression: Implications for Immune Regulation in Neurocysticercosis.
Epigenetic reprogramming in atherosclerosis.
Esculentoside A exerts anti-inflammatory activity in microglial cells.
Establishment of NF-?B sensing and interleukin-4 secreting mesenchymal stromal cells as an "on-demand" drug delivery system to modulate inflammation.
Ethanol Extract of Lilium Bulbs Plays an Anti-Inflammatory Role by Targeting the IKK[Formula: see text]/[Formula: see text]-Mediated NF-[Formula: see text]B Pathway in Macrophages.
Evaluation of a synthetic CArG promoter for nitric oxide synthase gene therapy of cancer.
Evaluation of the mechanism of vascular endothelial growth factor improvement of ischemic flap survival in rats.
Evidence for peroxynitrite-mediated modifications to p53 in human gliomas: possible functional consequences.
Exogenous interferon-gamma induces endogenous synthesis of interferon-alpha and -beta by murine macrophages for induction of nitric oxide synthase.
Experimental colitis reduces microglial cell activation in the mouse brain without affecting microglial cell numbers.
Expression of allograft inflammatory factor-1 in mouse uterus and poly(I:C)-induced fetal resorption.
Expression of an endothelial-type nitric oxide synthase isoform in human neutrophils: modification by tumor necrosis factor-alpha and during acute myocardial infarction.
Expression of nitric oxide synthase 2 and tumor necrosis factor alpha in swine naturally infected with Actinobacillus pleuropneumoniae.
Expression of nitric oxide synthase and nitric oxide-sensitive guanylate cyclase in the crustacean cardiac ganglion.
Expression of nitric oxide synthase in human central nervous system tumors.
Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer.
Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.
Expression of type 2 nitric oxide synthase and p53 in Warthin's tumour of the parotid.
Expression profile of NF-?B regulated genes in sporadic colorectal cancer patients.
Farnesol quells oxidative stress, reactive gliosis and inflammation during acrylamide-induced neurotoxicity: Behavioral and biochemical evidence.
Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-?B signaling pathways.
Fenofibrate ameliorates testicular damage in rats with streptozotocin-induced type 1 diabetes: role of HO-1 and p38 MAPK.
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.
First description of an olfactory neuroblastoma in goldfish Carassius auratus: a case report.
Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects.
Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells.
Fluorescence imaging microscopy of cellular markers in ischemic vs non-ischemic cardiomyopathy after left ventricular unloading.
Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.
Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia.
Function of neuronal nitric oxide synthase enzyme in temozolomide-induced damage of astrocytic tumor cells.
Functional benefit and molecular mechanism of vitamin C against perfluorooctanesulfonate-associated leukemia.
Galactosyl derivative of N(omega)-nitro-L-arginine: study of antiproliferative activity on human thyroid follicular carcinoma cells.
Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats.
Galangin Suppresses Renal Inflammation via the Inhibition of NF-?B, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells.
Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection.
Genetic polymorphisms of eNOS, hormone receptor status, and survival of breast cancer.
Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide.
Glial activation with concurrent up-regulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice.
Glioma tumourgenicity is decreased by iNOS knockout: experimental studies using the C6 striatal implantation glioma model.
Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E?.
Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass.
Glucocorticoid-induced leucine zipper (GILZ) over-expression in T lymphocytes inhibits inflammation and tissue damage in spinal cord injury.
Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells.
Glycyrrhiza glabra L. Extract Inhibits LPS-Induced Inflammation in RAW Macrophages.
Glycyrrhizic acid activates chicken macrophages and enhances their Salmonella-killing capacity in vitro.
GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.
Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice.
GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation.
Headache in patients with a meningioma correlates with a bone-invasive growth pattern but not with cytokine expression.
Hemodynamic effects of nitric oxide synthase inhibition at steady state and following tumor necrosis factor-alpha-induced myodepression.
Heparin and low-molecular-weight heparin (enoxaparin) significantly ameliorate experimental colitis in rats.
Heterozygosity at the A625C polymorphic site of the MyD88 gene is associated with Mycobacterium bovis infection in cattle.
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
High expression of endothelial cell nitric oxide synthase in peritumoral microvessels predicts increased disease-free survival in colorectal cancer.
Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling.
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity.
HIV-associated cardiomyopathy etiopathogenesis and clinical aspects.
Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart.
Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren.
Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway.
IL-12 induces T helper 1-directed antitumor response.
IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-gamma dependent manner.
IL-27 Negatively Regulates Tip-DC Development during Infection.
IL-6/NOS2 inflammatory signals regulate MMP-9 and MMP-2 activity and disease outcome in nasopharyngeal carcinoma patients.
Immunohistochemical characterization of nitric oxide synthase activity in squamous cell carcinoma of the head and neck.
Immunohistochemical localization of inducible and endothelial constitutive nitric oxide synthase in neoplastic and autoimmune thyroid disorders.
Immunohistochemical study on inducible type of nitric oxide (iNOS), basic fibroblast growth factor (bFGF) and tumor growth factor-beta1 (TGF-beta1) in arteritis induced in rats by fenoldopam and theophylline, vasodilators.
Immunomodulation of Tumor Microenvironment by Arginine-Loaded Iron Oxide Nanoparticles for Gaseous Immunotherapy.
Immunoregulating properties of peptides related to tumor rejection antigens: effect on human monocytes and natural killer cells.
Immunostaining for cell picking and real-time mRNA quantitation.
Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide.
Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition.
In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.
In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study.
In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents.
In vivo anti-inflammatory activities of the essential oil from Radix Angelicae dahuricae.
In vivo expression of monokine and inducible nitric oxide synthase in experimentally induced pulmonary granulomatous inflammation. Evidence for sequential production of interleukin-1, inducible nitric oxide synthase, and tumor necrosis factor.
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties.
Increased nitric oxide synthase activity as a cause of mitochondrial dysfunction in rat hepatocytes: roles for tumor necrosis factor alpha.
Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival.
Inducible nitric oxide synthase expression correlates with angiogenesis, lymphangiogenesis, and poor prognosis in gastric cancer patients.
Inducible nitric oxide synthase in a human glioblastoma cell line.
Inducible nitric oxide synthase in vascular smooth muscle.
Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide.
Inducible nitric oxide synthase-mediated proliferation of a T lymphoma cell line.
Induction of a macrophage-like nitric oxide synthase in cultured rat aortic endothelial cells. IL-1 beta-mediated induction regulated by tumor necrosis factor-alpha and IFN-gamma.
Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine.
Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets.
Induction of nitric oxide synthase (NOS) by soluble glucocorticoid induced tumor necrosis factor receptor (sGITR) is modulated by IFN-gamma in murine macrophage.
Induction of nitric oxide synthase activity in adrenal cells.
Induction of nitric oxide synthase and nitric oxide-mediated apoptosis in neuronal PC12 cells after stimulation with tumor necrosis factor-alpha/lipopolysaccharide.
Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role.
Induction of nitric oxide synthase in the neo-vasculature of experimental tumours in mice.
Induction of nitric oxide synthase is a necessary precondition for expression of tumor necrosis factor-independent tumoricidal activity by activated macrophages.
Induction of nitric oxide synthase is involved in the mechanism of Fas-mediated apoptosis in haemopoietic cells.
Induction of the nitric oxide-synthesizing pathway in fresh and interleukin 2-cultured rat natural killer cells.
Inflammatory and oxidative stress?associated factors in chronic intermittent hypoxia in Chinese patients, rats, lymphocytes and endotheliocytes.
Inflammatory mechanism of cerebral ischemia-reperfusion injury with treatment of stepharine in rats.
Inflammatory mediators stimulate arginine transport and arginine-derived nitric oxide production in a murine breast cancer cell line.
Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.
Influence of C-phycocyanin on hepatocellular parameters related to liver oxidative stress and Kupffer cell functioning.
Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis.
Infusion of exogenous tumor necrosis factor dose dependently alters the length of the luteal phase in cattle: differential responses to treatment with indomethacin and L-NAME, a nitric oxide synthase inhibitor.
Inhibition of induced nitric oxide synthase enhances the anti-tumor effects on cancer immunotherapy using TLR7 agonist in mice.
Inhibition of inducible nitric oxide synthase expression by endothelin in rat glial cells prepared from the neonatal rat brain.
Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice.
Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.
Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells.
Inhibition of prothrombin kringle-2-induced inflammation by minocycline protects dopaminergic neurons in the substantia nigra in vivo.
Inhibition of sevoflurane postconditioning against cerebral ischemia reperfusion-induced oxidative injury in rats.
Inhibition of Tumor Progression by NG-Nitro-L-arginine Methyl Ester in 7,12- dimethylbenz(a)anthracene Induced Breast Cancer: Nitric Oxide Synthase Inhibition as an Antitumor Prevention.
iNOS as a therapeutic target for treatment of human tumors.
Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells.
Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase.
Interaction of o, p'DDT with the estrogen-binding protein (EBP) in human mammary and uterine tumors.
Interaction of o,p'-DDT with the estrogen-binding protein (EBP) of DMBA-induced rat mammary tumors.
Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression.
Interferon-? plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways.
Interferon-gamma and interleukin-2 stimulate production of a soluble factor by L1210 and P815 tumor targets to promote macrophage activation.
Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
Interleukin (IL)-12 receptor beta1 or IL-12 receptor beta 2 deficiency in mice indicates that IL-12 and IL-23 are not essential for host recovery from viral encephalitis.
Interleukin 1 beta and tumour necrosis factor alpha induce a macrophage-type of nitric oxide synthase in rat renal mesangial cells.
Interleukin-10 gene transfer inhibits murine mammary tumors and elevates nitric oxide.
Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora.
Interleukin-12 promotes recovery from viral encephalitis.
Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis.
Intracochlear Bleeding Enhances Cochlear Fibrosis and Ossification: An Animal Study.
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.
Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site.
Involvement of nitric oxide synthase in antiproliferative activity of macrophages: induction of the enzyme requires two different kinds of signal acting synergistically.
Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere Generation.
INVOLVEMENT OF TUMOR NECROSIS FACTOR-{alpha} IN THE NATRIURETIC RESPONSE TO SYSTEMIC INFUSION OF NITRIC OXIDE SYNTHASE INHIBITOR IN ANESTHETIZED MICE.
Ionizing radiation potentiates the induction of nitric oxide synthase by interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines. Role of tumor necrosis factor-alpha.
Ischaemic preconditioning prevents the liver inflammatory response to lung ischaemia/reperfusion in a swine lung autotransplant model.
Ischemia reperfusion injury in tumors: the role of oxygen radicals and nitric oxide.
Isolation of bead phagosomes to study virulence function of M. tuberculosis cell wall lipids.
Isosteviol Sodium Protects Neural Cells Against Hypoxia-Induced Apoptosis Through Inhibiting MAPK and NF-?B Pathways.
Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy.
L-Type Calcium Channels and mu-Opioid Receptors are Involved in Mediating the Anti-Inflammatory Effects of Naloxone.
L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate.
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion.
Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.
Local lymphocytes and nitric oxide synthase in the uterine cervical stroma of patients with grade III cervical intraepithelial neoplasia.
Loss of NOS1 expression in high-grade renal cell carcinoma associated with a shift of NO signalling.
Lovastatin Reduces Apoptosis and Downregulates the CD40 Expression Induced by TNF-alpha in Cerebral Vascular Endothelial Cells.
Low-dose celecoxib improves coronary function after acute myocardial ischaemia in rabbits.
Low-dose combretastatin A4 phosphate enhances the immune response of tumor hosts to experimental colon carcinoma.
Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-?-induced inflammatory reactions in microglial cells.
Macrophage nitric oxide synthesis delays progression of ultraviolet light-induced murine skin cancers.
Mannose Receptor Mediates the Activation of Chitooligosaccharides on Blunt Snout Bream (Megalobrama amblycephala) Macrophages.
Maternal pomegranate juice attenuates maternal inflammation-induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-?B in a rat model.
Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis.
Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva.
Mechanism of neopterin-induced myocardial dysfunction in the isolated perfused rat heart.
Metabolic and clonogenic consequences of ischaemia reperfusion insult in solid tumours.
Methylene Blue inhibits the inflammatory process of the acetic acid-induced colitis in the rat colonic mucosa.
Micheliolide suppresses LPS-induced neuroinflammatory responses.
Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.
MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1.
Mitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: Implications for breast Cancer.
Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability.
Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine.
Modulation of growth factor and cytokine expression by nitric oxide during rat colon anastomotic healing.
Modulation of inducible nitric oxide synthase expression in rat intestinal cells by colon tumor promoters.
Modulation of protein tyrosine nitration and inflammatory mediators by isoprenylhydroquinone glucoside.
Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism.
Monochloramine induces acute and protracted colitis in the rat: response to pharmacological treatment.
Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair.
Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide.
Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants.
Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation.
MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression.
Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice.
Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
N-Methyl-d-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat.
NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions.
Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms.
Neuroprotective effect of total flavonoids from Ilex pubescens against focal cerebral ischemia/reperfusion injury in rats.
Neuroprotective properties of statins.
Neutralization by "antineoplastin" of insulin-activated nitric oxide synthase antibody and its effects in cancers.
Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model.
NF-?B activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock.
Nickel and Oxidative stress: Cell Signaling Mechanisms and Protective Role of Vitamin C.
Nitric oxide (NO) synthase activity in the lung and NO synthesis in alveolar macrophages of rats increased on exposure to asbestos.
Nitric oxide activates metalloprotease enzymes in articular cartilage.
Nitric oxide and cancer therapy: the emperor has NO clothes.
Nitric oxide and nitric oxide synthase mRNA induction in mouse islet cells by interferon-gamma plus tumor necrosis factor-alpha.
Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.
Nitric oxide enhances cyclooxygenase activity in articular cartilage.
Nitric oxide exposure of CC531 rat colon carcinoma cells induces gamma-glutamyltransferase which may counteract glutathione depletion and cell death.
Nitric Oxide in Hematological Cancers: Partner or Rival?
Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells.
Nitric oxide inhibits autophagy and promotes apoptosis in hepatocellular carcinoma.
Nitric oxide modulates capillary formation at the endothelial cell-tumor cell interface.
Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion.
Nitric oxide synthase (eNOS4a/b) gene polymorphism is associated with tumor recurrence and progression in superficial bladder cancer cases.
Nitric oxide synthase (NOS-I) in Leydig cells of the human testis.
Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns.
Nitric oxide synthase activity in fresh cells from ovarian tumour tissue: relationship of enzyme activity with clinical parameters of patients with ovarian cancer.
Nitric oxide synthase activity in human gynecological cancer.
Nitric oxide synthase activity in human squamous cell carcinoma of the head and neck.
Nitric oxide synthase and cytochrome c oxidase changes in the tumoural and peritumoural cerebral cortex.
Nitric oxide synthase and skin tumor promotion.
Nitric oxide synthase gene therapy enhances the toxicity of cisplatin in cancer cells.
Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production.
Nitric oxide synthase II suppresses the growth and metastasis of human cancer regardless of its up-regulation of protumor factors.
Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors.
Nitric oxide synthase inhibition and cancer.
Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors.
Nitric oxide synthase inhibition enhances the antitumor effect of radiation in the treatment of squamous carcinoma xenografts.
Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses.
Nitric oxide synthase inhibition results in synergistic anti-tumour activity with melphalan and tumour necrosis factor alpha-based isolated limb perfusions.
Nitric oxide synthase is expressed in experimental malignant glioma and influences tumour blood flow.
Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha.
Nitric oxide synthase mRNA in endothelial cells: synergistic induction by interferon-gamma, tumor necrosis factor-alpha and lipopolysaccharide and inhibition by dexamethasone.
Nitric Oxide Synthase Potentiates the Resistance of Cancer Cell Lines to Anticancer Chemotherapeutics.
Nitric oxide synthase-cyclooxygenase interactions are involved in tumor cell angiogenesis and migration.
Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis.
Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.
Nitric oxide--a novel therapeutic for cancer.
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses.
Nitric oxide-mediated promotion of mammary tumour cell migration requires sequential activation of nitric oxide synthase, guanylate cyclase and mitogen-activated protein kinase.
Nitric-oxide-donating NSAIDs as agents for cancer prevention.
NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study.
NO? and Pancreatic Cancer: A complex interaction with therapeutic potential.
NOS Expression and NO Function in Glioma and Implications for Patient Therapies.
NOS1
NOS1 expression promotes proliferation and invasion and enhances chemoresistance in ovarian cancer.
NOS1 upregulates ABCG2 expression contributing to DDP chemoresistance in ovarian cancer cells.
NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.
NOS2 as an Emergent Player in Progression of Cancer.
NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line.
Novel Interaction of Ornithine Decarboxylase with Sepiapterin Reductase Regulates Neuroblastoma Cell Proliferation.
NO• /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer.
Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha.
Obesity-Related Perivascular Adipose Tissue Damage Is Reversed by Sustained Weight Loss in the Rat.
On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Opiate signaling regulates microglia activities in the invertebrate nervous system.
Oral administration of recombinant epinecidin-1 protected grouper (Epinephelus coioides) and zebrafish (Danio rerio) from Vibrio vulnificus infection and enhanced immune-related gene expressions.
Origanum?Vulgare?L. Extracts Versus Thymol: An Anti?Inflammatory Study on Activated Microglial and Mixed Glial Cells
Osthole inhibits proliferation of kainic acid?activated BV?2 cells by modulating the Notch signaling pathway.
Overexpressed human RAD50 exhibits cell death in a p21(WAF1/CIP1)-dependent manner: its potential utility in local gene therapy of tumor.
Overexpression of endothelium-derived nitric oxide synthase isoform 3 in the vasculature of human pancreatic tumor biopsies.
Overexpression of inflammatory-related and nitric oxide synthase genes in olfactory bulbs from frontal lobe epilepsy patients.
Oxidative damage and antioxidants in cervical cancer.
Oxidative signalling and inflammatory pathways in Alzheimer's disease.
Oxidative stress, mitochondria, and apoptosis.
p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells.
Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells.
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Part I. Molecular and cellular characterization of high nitric oxide-adapted human breast adenocarcinoma cell lines.
Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines.
Pathogenesis of portal hypertensive gastropathy: a clinical and experimental review.
Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid.
Physiological and structural changes of the lung tissue in male albino rat exposed to immobilization stress.
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.
PKR inhibition mediates endotoxin tolerance in macrophages through inactivation of PI3K/AKT signaling.
Pleurotus nebrodensis polysaccharide (PN-S) enhances the immunity of immunosuppressed mice.
Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility.
Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury.
Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors.
Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats.
Potentiation of photodynamic therapy antitumor activity in mice by nitric oxide synthase inhibition is fluence rate dependent.
Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis.
Pretreatment with a monoclonal antibody/interleukin-2 fusion protein directed against DNA enhances the delivery of therapeutic molecules to solid tumors.
Prevention of hepatopulmonary syndrome and hyperdynamic state by pentoxifylline in cirrhotic rats.
Probiotic properties of novel probiotic Levilactobacillus brevis KU15147 isolated from radish kimchi and its antioxidant and immune-enhancing activities.
Profiling of jejunum inflammatory gene expression during murine eimeriosis.
Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia.
Propolis ameliorates tumor Nerosis factor-?, nitric oxide levels, caspase-3 and nitric oxide synthase activities in Kainic acid mediated excitotoxicity in rat brain.
Prospects for bioreductive drug development.
Protective effect of genistein on lipopolysaccharide/D-galactosamine- induced hepatic failure in mice.
Protective effect of genistein on lipopolysaccharide/d-galactosamine-induced hepatic failure in mice.
Protective Effect of MFG-E8 after Cutaneous Ischemia-Reperfusion Injury.
Protective effect of NG-monomethyl-L-arginine against hypotension inducted by combined tumour necrosis factor-alpha and whole body hyperthermia in rats.
Protective effect of vascular endothelial growth factor against cardiopulmonary bypass-associated acute kidney injury in beagles.
Protective effects of atorvastatin against morphine-induced tolerance and dependence in mice.
Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice.
Protective effects of maslinic acid against alcohol-induced acute liver injury in mice.
Proteolytic cleavage confers nitric oxide synthase inducing activity upon prolactin.
Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase.
Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model.
Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters.
Radical-scavenging and Pro-/anti-inflammatory Activity of Tetracycline and Related Phenolic Compounds With or Without Visible Light Irradiation.
Radiofrequency ablation of invasive breast carcinomas: a phase II trial.
Red bean extracts protect rats against intestinal inflammatory damage.
Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione.
Regulatory roles of PGE2 in LPS-induced tissue damage in bovine endometrial explants.
Relationship of tumor necrosis factor alpha, the nitric oxide synthase pathway, and lipopolysaccharide to the killing of gamma interferon-treated macrophage-like RAW264.7 cells by Rickettsia prowazekii.
Remote tissue injury primes hepatocytes for nitric oxide synthesis.
Research on mechanism of PCS in damaging vascular endothelial cells and promoting formation of atherosclerosis via TLR4/TREM-1.
Retraction. Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-alpha and nitric oxide synthase.
Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation.
RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE?
Role of angiotensin II, endothelin-1, and nitric oxide in HgCl2-induced acute renal failure.
Role of ecNOS-derived NO in mediating TNF-induced endothelial barrier dysfunction.
Role of nitric oxide in cell-mediated tumor cytotoxicity.
Role of nitric oxide in tumour progression: lessons from human tumours.
Role of phenolic compounds in nitric oxide synthase activity in colon and breast adenocarcinoma.
Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats.
Role of the nitric oxide synthase pathway in inhibition of growth of interferon-sensitive and interferon-resistant Rickettsia prowazekii strains in L929 cells treated with tumor necrosis factor alpha and gamma interferon.
Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock.
Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects.
Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.
Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium-induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation.
Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation.
Selenomethionine relieves inflammation in the chicken trachea caused by LPS though inhibiting the NF-?B pathway.
Sepiapterin Enhances Tumor Radio- and Chemosensitivities by Promoting Vascular Normalization.
Shenfu injection improves cerebral microcirculation and reduces brain injury in a porcine model of hemorrhagic shock.
Shikonofuran E plays an anti-inflammatory role by down-regulating MAPK and NF-?B signaling pathways in lipopolysaccharide-stimulated RAW264.7 macrophages.
Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells.
Simultaneous expression of nitric oxide synthase and estrogen receptor in human breast cancer cell lines.
Simvastatin prevents morphine-induced tolerance and dependence in mice.
Single nucleotide polymorphisms in NOS2A and NOS3 genes are not associated with treatment response of non-small cell lung cancer patients following the definitive radiochemotherapy.
Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis.
SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses.
Sphingosine 1-Phosphate (S1P)/S1P Receptor2/3 Axis Promotes Inflammatory M1 Polarization of Bone Marrow-Derived Monocyte/Macrophage via G(?)i/o/PI3K/JNK Pathway.
Stable expression in a Chinese hamster ovary (CHO) cell line of bioactive recombinant chelonianin, which plays an important role in protecting fish against pathogenic infection.
Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour.
Structure and biological activities of acapsular Cryptococcus neoformans 602 complemented with the CAP64 gene.
Study on different pathogenic factors in different disease stages of patients with Wilson disease.
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation.
Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation.
Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor.
Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by conjugated linoleic acid in murine macrophages.
Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade.
Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells.
Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-?B and MAPK signaling pathways.
Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NF?B inhibitors.
Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase.
Taenia solium and Taenia crassiceps: miRNomes of the larvae and effects of miR-10-5p and let-7-5p on murine peritoneal macrophages.
Targeted delivery of radioprotective agents to mitochondria.
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling.
Taxol provides a second signal for murine macrophage tumoricidal activity.
Temporal expression of tumor necrosis factor-alpha and nitric oxide synthase 2 in rat small intestine after endotoxin.
Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-?b and p38 pathways in zebrafish.
Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin.
Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure.
Thalidomide as a multi-template for development of biologically active compounds.
Thapsigargin, a Ca(2+)-ATPase inhibitor, relaxes guinea pig tracheal smooth muscle by producing epithelium-dependent relaxing factors.
The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Protein mRNA Level in Chicken Cartilage Tissue.
The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes.
The crustin-like peptide plays opposite role in shrimp immune response to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection.
The effect of 131I-induced hypothyroidism on the levels of nitric oxide (NO), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-?), total nitric oxide synthase (NOS) activity, and expression of NOS isoforms in rats.
The effects of chronic nitric oxide synthase suppression on glioma pathophysiology.
The impact of immunohistochemical expression of nitric oxide synthases on clinical and pathological features of renal cell carcinoma.
The importance of nitric oxide in the cytokine-induced inhibition of glucose formation by cultured hepatocytes incubated with insulin, dexamethasone, and glucagon.
The influence of nitric oxide on tumour vascular tone.
The Involvement of Arginase and Nitric Oxide Synthase in Breast Cancer Development: Arginase and NO Synthase as Therapeutic Targets in Cancer.
The Liver Protection Effects of Maltol, a Flavoring Agent, on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Inhibiting Apoptosis and Inflammatory Response.
The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses.
The modulation of IL-6 and TNF-alpha release by nitric oxide following stimulation of J774 cells with LPS and IFN-gamma.
The preventive role of breadfruit against inflammation-associated epithelial carcinogenesis in mice.
The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction.
The radiosensitizing effect of immunoadjuvant OM-174 requires cooperation between immune and tumor cells through interferon-gamma and inducible nitric oxide synthase.
The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.
The role of IL-10 in iNOS and cytokine mRNA expression during in vitro differentiation of bovine mononuclear phagocytes.
The role of nitric oxide in bacillus Calmette-Guérin mediated anti-tumour effects in human bladder cancer.
The role of nitric oxide in hepatic metabolism.
The role of nitric oxide in the treatment of tumours with aminolaevulinic acid-induced photodynamic therapy.
The Role of Nitric Oxide Synthase Uncoupling in Tumor Progression.
The Role of PARP-1 in Host-Pathogen Interaction and Cellular Stress Responses.
The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis.
The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin.
The role of thiamine in cancer: possible genetic and cellular signaling mechanisms.
The short-lived exostosis induced surgically versus the lasting genetic hereditary multiple exostoses.
The therapeutic role of interleukin-10 after spinal cord injury.
The transcriptional cascade associated with creatine kinase down-regulation and mitochondrial biogenesis in mice sarcoma.
Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders.
Thyroid hormones as modulators of immune activities at the cellular level.
Thyroid hormones increase inducible nitric oxide synthase gene expression downstream from PKC-zeta in murine tumor T lymphocytes.
Tipping the Balancing ACT.
TNFA locus is associated with beta degrees 39 thalassemia in Corsica and Sardinia.
Toll-Interleukin 1 Receptor domain-containing adaptor protein positively regulates BV2 cell M1 polarization.
Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury.
Total glucosides of paeony (TGP) alleviates constipation and intestinal inflammation in mice induced by Sjögren's syndrome.
Transfer factors as immunotherapy and supplement of chemotherapy in experimental pulmonary tuberculosis.
Transforming growth factor beta 2 inhibits interleukin 1 beta- and tumour necrosis factor alpha-induction of nitric oxide synthase in rat renal mesangial cells.
Transient block of respiratory chain by cyanide triggers NADPH-diaphorase activity (a marker for nitric oxide synthase) in Dunning rat prostatic epithelium.
Treatment with ginseng total saponins reduces the secondary brain injury in rat after cortical impact.
Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo.
Tumor growth enhancing effects of vascular endothelial growth factor are associated with increased nitric oxide synthase activity and inhibition of apoptosis in human breast carcinoma xenografts.
Tumor Necrosis Factor (TNF) -308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis.
Tumor necrosis factor ? decreases nitric oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limb.
Tumor necrosis factor alpha augments nitric oxide-dependent macrophage cytotoxicity against Entamoeba histolytica by enhanced expression of the nitric oxide synthase gene.
Tumor necrosis factor alpha regulates nitric oxide synthase expression in portal hypertensive gastric mucosa of rats.
Tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia.
Tumor Necrosis Factor-Alpha Regulates Inducible Nitric Oxide Synthase Gene Expression in the Portal Hypertensive Gastric Mucosa of the Rat.
Tumor-derived factor synergizes with IFN-gamma and LPS, IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF receptors for autocrine induction of nitric oxide synthase and enhanced nitric oxide-mediated tumor cytotoxicity.
Tumoricidal response of liver macrophages isolated from rats bearing liver metastases of colon adenocarcinoma.
Tumour necrosis factor alpha stimulates nitric oxide production more potently than interleukin-1beta in porcine articular chondrocytes.
Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line RAW 264.7.
U.S.-Japan Cooperative Cancer Research Program: seminar on nitric oxide synthase and carcinogenesis.
Ulinastatin attenuates experimental autoimmune encephalomyelitis by enhancing anti-inflammatory responses.
Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization.
Up-regulation of endothelin-1 in gastric mucosal inflammatory responses to Helicobacter pylori Lipopolysaccharide: effect of omeprazole and sucralfate.
Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways.
USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-?B signaling pathway in mice.
VitA or VitD ameliorates bronchopulmonary dysplasia by regulating the balance between M1 and M2 macrophages.
Vitamin D improves sunburns by increasing autophagy in M2 macrophages.
Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation.
Walking Training Improves Systemic and Local Pathophysiological Processes in Intermittent Claudication.
Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-?B and JNK MAPK Signaling in Adult Mice Challenged by LPS.
Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice.
Xenobiotic-metabolising enzymes in patients with adenocarcinoma of the breast: Correlation with clinical stage and menopausal status.
Xenobiotic-metabolizing enzymes in canine mammary tumours.
Zeaxanthin exerts protective effects on acetic acid-induced colitis in rats via modulation of pro-inflammatory cytokines and oxidative stress.
[6]-Gingerol impedes 7,12-dimethylbenz(a)anthracene-induced inflammation and cell proliferation-associated hamster buccal pouch carcinogenesis through modulating Nrf2 signaling events.
[Effect of decellularized adipose tissue combined with vacuum sealing drainage on wound inflammation in pigs].
[Effect of electroacupuncture on pulmonary function and M1 polarization of alveolar macrophages in rats with chronic obstructive pulmonary disease].
[Effect of ligation of mesenteric lymph duct on inflammation response of liver in hemorrhagic shock in rats]
[Effects of glutamine on alpha-sarcomeric actin and its mRNA expression of myocardium in rats with endotoxemia]
[Expression and significance of nitric oxide synthase mRNAs and proteins in giant cell tumors of bone]
[Expression of genes related to inflammatory response in myocardium of rats after burn injury]
[Expression of inductive nitric oxide synthase and vascular endothelial growth factor in colonic carcinoma, and their effects on tumor angiogenesis]
[Hepatitis A virus cell membrane protein receptor 2 promotes endotoxin tolerance in mouse macrophages].
[Histocytospectrophotometric characteristics of lung cancer]
[Relation between nitric oxide, nitric oxide synthase and angiogenesis in tumor]
[Research advances on tumor therapy via nitric oxide]
[Role of different isoforms of nitric oxide synthase in development of tumor mutants in Drosophila melanogaster]
[Role of nitric oxide in cholecystokinin octapeptide alleviation of tumor necrosis factor alpha induced changes in rabbit pulmonary arterial reactivity]
[The correlations between plasma TNF-alpha, NO, NOS levels and brain lateralization in mice]
[The protective effects and mechanisms of Trillium tschonoskii Maxim on rats' liver damage induced by lipopolysaccharide].
[The study of nitric oxide synthase in ovary tumor]
[Tumor necrosis factor-alpha and interferon-gamma modulate in vitro expression of nitric oxide synthase in human nasal epithelial cells]
Nephritis
Changes in inducible nitric oxide synthase expression in experimental glomerulonephritis.
Linomide administration to mice attenuates the induction of nitric oxide synthase elicited by lipopolysaccharide-activated macrophages and prevents nephritis in MRL/Mp-lpr/lpr mice.
Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase.
Nitric oxide synthase isoform expression in acute versus chronic anti-Thy 1 nephritis.
Renoprotective effects of captopril in hypertension induced by nitric oxide synthase inhibition in experimental nephritis.
Role of nitric oxide in rat nephrotoxic nephritis: comparison between inducible and constitutive nitric oxide synthase.
Nephritis, Interstitial
Inhibition of inducible nitric oxide synthase intensifies injury and functional deterioration in autoimmune interstitial nephritis.
Nephrolithiasis
Changes in nitric oxide production in the rat kidney due to CaOx nephrolithiasis.
Nephrosclerosis
Differential effects of antihypertensive drugs on renal and glomerular hemodynamics and injury in the chronic nitric-oxide-suppressed rat.
Nephrosis, Lipoid
Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.
Nephrotic Syndrome
Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria.
Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.
Nervous System Diseases
Biochemical and histochemical studies of the effects of cerebral metabolism-improving drugs on NADPH diaphorase activity in mouse brain.
Differential vulnerability of two subsets of spinal motor neurons in amyotrophic lateral sclerosis.
Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity.
Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition.
N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.
[Study on the changes in endogenous oxidation agents and levels of anti-oxidation agents in patients with cerebral vascular disease]
Neural Tube Defects
Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype.
Modulation of nuclear factor-?B signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice.
Neuralgia
A synthetic kainoid, (2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid (PSPA-1) serves as a novel anti-allodynic agent for neuropathic pain.
Analgesic effect of extracts of Chinese medicinal herbs Moutan cortex and Coicis semen on neuropathic pain in mice.
Application of nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats.
Aripiprazole prevents from development of vincristine-induced neuropathic nociception by limiting neural NOS overexpression and NF-kB hyperactivation.
Comparison of mechanisms of allodynia induced by acromelic acid A between early and late phases.
Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.
Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice.
Early hyperbaric oxygen effects on neuropathic pain and nitric oxide synthase isoforms in CCI rats.
Effect of intrathecal NG-nitro-L-arginine methyl ester administration on Fos expression in the spinal dorsal horn in rats following sciatic nerve ligation.
Effect of prolonged administration of bovine lactoferrin in neuropathic pain: involvement of opioid receptors, nitric oxide and TNF-alpha.
Effects of hyperbaric oxygen on pain-related behaviors and nitric oxide synthase in a rat model of neuropathic pain.
Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats.
Effects of selective inhibition of nNOS and iNOS on neuropathic pain in rats.
First-in-Class, Dual Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain.
Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain.
Increased nitric oxide synthase immunoreactivity in rat dorsal root ganglia in a neuropathic pain model.
Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain.
Local nitric oxide synthase activity in a model of neuropathic pain.
N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development.
NADPH-d and Fos reactivity in the rat spinal cord following experimental spinal cord injury and embryonic neural stem cell transplantation.
Neuropathic pain in rats is associated with altered nitric oxide synthase activity in neural tissue.
Neuropathic pain is associated with alterations of nitric oxide synthase immunoreactivity and catalytic activity in dorsal root ganglia and spinal dorsal horn.
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.
Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.
Phosphorylated neuronal nitric oxide synthase in neuropathic pain in rats.
Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain.
Relationship between neuronal nitric oxide synthase and NADPH-diaphorase in the dorsal root ganglia during neuropathic pain.
Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain.
Systemic agmatine attenuates tactile allodynia in two experimental neuropathic pain models in rats.
Time-course of neuropathic pain in mice deficient in neuronal or inducible nitric oxide synthase.
ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
[Effects of nitric oxide synthase inhibitor on hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury].
[Electroacupuncture relieved neuropathic pain by suppressing L-Arg/NO/cGMP pathway in the lumbar spinal cord in rats with spared nerve injury].
Neuritis
Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis.
Neuritis, Autoimmune, Experimental
Administration of nitric oxide synthase inhibitors in experimental autoimmune neuritis and experimental autoimmune encephalomyelitis.
Neurobehavioral Manifestations
mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease.
Neuroblastoma
Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines.
Expressional down-regulation of neuronal-type nitric oxide synthase I by glucocorticoids in N1E-115 neuroblastoma cells.
High concentration of L-arginine suppresses nitric oxide synthase activity and produces reactive oxygen species in NB9 human neuroblastoma cells.
Immunochemical characterization and measurement of neuronal type nitric oxide synthase in human neuroblastoma NB-OK-1 cell using novel anti-synthetic peptide antibody and specific immunoassay system.
Induction of adhesion/differentiation of human neuroblastoma cells by tumour necrosis factor-alpha requires the expression of an inducible nitric oxide synthase.
Induction of nitric oxide synthase in glial cells.
Low levels of selenium compounds are selectively toxic for a human neuron cell line through ROS/RNS increase and apoptotic process activation.
Mechanisms of cytokine-mediated inhibition of viral replication.
Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.
Nitric oxide synthase expression in human neuroblastoma cell line induced by cytokines.
Nitric oxide synthases in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity.
The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I.
Neurocysticercosis
Epigenetic Modulation of Microglial Inflammatory Gene Loci in Helminth-Induced Immune Suppression: Implications for Immune Regulation in Neurocysticercosis.
Neurodegenerative Diseases
A novel neuronal messenger molecule in brain: the free radical, nitric oxide.
Design of isoform-selective inhibitors of nitric oxide synthase.
Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.
Increases in [3H]FK-506 and [3H]L-N(G)-nitro-arginine binding in the rat brain after nigrostriatal dopaminergic denervation.
Induction of cytosolic NADPH-diaphorase/nitric oxide synthase in reactive microglia/macrophages after quinolinic acid lesions in the rat striatum: an electron and light microscopical study.
Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases.
Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations.
Neuritic sprouting with aberrant expression of the nitric oxide synthase III gene in neurodegenerative diseases.
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
Pathological implications of iNOS expression in central white matter: an ex vivo study of optic nerves from rats with experimental allergic encephalomyelitis.
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Potential role of ursodeoxycholic acid in suppression of nuclear factor kappa B in microglial cell line (BV-2).
Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture.
Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC.
Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors.
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
Neurogenic Inflammation
Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion.
Neuroinflammatory Diseases
Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry.
Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells.
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.
Simvastatin combined with antioxidant attenuates the cerebral vascular endothelial inflammatory response in a rat traumatic brain injury.
Synergic Therapeutic Potential of PEA-Um Treatment and NAAA Enzyme Silencing In the Management of Neuroinflammation.
The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.
Neurologic Manifestations
Nitric oxide reversibly impairs axonal conduction in Guinea pig spinal cord.
Neuroma
Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves.
Neutropenia
Role of neutrophils and nitric oxide in lung alveolar injury from smoke inhalation.
nitric-oxide synthase (nadph) deficiency
Nitric oxide in the peripheral nervous system.
Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.
Nocturnal Enuresis
Nitric oxide synthase gene polymorphisms in children with primary nocturnal enuresis: a preliminary study.
Non-alcoholic Fatty Liver Disease
Dimethylarginine dimethylaminohydrolase 1 protects against high fat diet induced hepatic steatosis and insulin resistance in mice.
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients.
Obesity
Anti-obesity and anti-diabetic effects of nitrate and nitrite.
Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study.
Cafeteria diet-induced obesity reduces leptin-stimulated NADPH-diaphorase reactivity in the hypothalamic arcuate nucleus of rats.
Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin.
Functional G894T (rs1799983) polymorphism and intron-4 VNTR variant of nitric oxide synthase (NOS3) gene are susceptibility biomarkers of obesity among Tunisians.
Hormonal Regulation of Nitric Oxide (NO) in Cardio-Metabolic Diseases.
Imeglimin prevents heart failure with preserved ejection fraction by recovering the impaired unfolded protein response in mice subjected to cardiometabolic stress.
Impact of obesity and nitric oxide synthase gene G894T polymorphism on essential hypertension.
iNOS as a metabolic enzyme under stress conditions.
Metformin restores the penile expression of nitric oxide synthase in high-fat-fed obese rats.
Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance.
Obesity, insulin resistance, and skeletal muscle nitric oxide synthase.
Obesity-Related Perivascular Adipose Tissue Damage Is Reversed by Sustained Weight Loss in the Rat.
Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: methods to quantitate mechanisms of insulin resistance.
Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine.
Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet.
Sex differences in renal nitric oxide synthase, NAD(P)H oxidase, and blood pressure in obese Zucker rats.
The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents.
The Role of Obesity in Preeclampsia.
The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action.
Thrombosis and occlusion of vascular access in hemodialyzed patients.
[Clinical study on female obesity complicated with climacteric syndrome treated by acupuncture]
Obstetric Labor, Premature
Dual roles of amniotic fluid nitric oxide and prostaglandin E2 in preterm labor with intra-amniotic infection.
Ocular Hypertension
Lamotrigine monotherapy does not provide protection against the loss of optic nerve axons in a rat model of ocular hypertension.
Oligodendroglioma
Nitric oxide synthase expression of oligodendrogliomas.
Opportunistic Infections
Blocking CXCL1-dependent neutrophil recruitment prevents immune damage and reduces pulmonary bacterial infection after inhalation injury.
Optic Nerve Injuries
Changes in NADPH diaphorase expression in the fish visual system during optic nerve regeneration and retinal development.
Characterization of NADPH-diaphorase-positive glial cells of the tench optic nerve after axotomy.
CNTF and BDNF have similar effects on retinal ganglion cell survival but differential effects on nitric oxide synthase expression soon after optic nerve injury.
Dose-dependent and combined effects of N-methyl-D-aspartate receptor antagonist MK-801 and nitric oxide synthase inhibitor nitro-L-arginine on the survival of retinal ganglion cells in adult hamsters.
Effects of axotomy on the expression of NADPH-diaphorase in the visual pathway of the tench.
Increased expression of NADPH-diaphorase in visual centres after unilateral optic nerve transection in the rat.
Orthostatic Intolerance
Cutaneous Constitutive Nitric Oxide Synthase Activation in Postural Tachycardia Syndrome with Splanchnic Hyperemia.
Osteoarthritis
A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage.
A novel mechanism of action of tetracyclines: effects on nitric oxide synthases.
Behaviour of nitric oxide synthase isoforms in inflammatory human joint diseases: an immunohistochemical study.
Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation.
Electromagnetic fields instantaneously modulate nitric oxide signaling in challenged biological systems.
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis.
Interactions between the inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) pathways: implications for therapeutic intervention in osteoarthritis.
Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism.
Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis.
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Tetracycline use in treating osteoarthritis: a systematic review.
WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology.
Osteonecrosis
Association between NOS3 polymorphisms and osteonecrosis of the femoral head.
Osteophyte
A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage.
Osteosarcoma
CoCr wear particles generated from CoCr alloy metal-on-metal hip replacements, and cobalt ions stimulate apoptosis and expression of general toxicology-related genes in monocyte-like U937 cells.
Otitis Media
Decreased Expression of TLR-9 and Cytokines in the Presence of Bacteria in Patients with Otitis Media with Effusion.
Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion.
Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion.
Nitric oxide synthase activity and nitric oxide level in erythrocytes of guinea pigs with experimental otitis media with effusion.
Toll-like receptors, cytokines & nitric oxide synthase in patients with otitis media with effusion.
Otitis Media with Effusion
Decreased Expression of TLR-9 and Cytokines in the Presence of Bacteria in Patients with Otitis Media with Effusion.
Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion.
Effects of tumor necrosis factor alpha antagonist, platelet activating factor antagonist, and nitric oxide synthase inhibitor on experimental otitis media with effusion.
Nitric oxide synthase activity and nitric oxide level in erythrocytes of guinea pigs with experimental otitis media with effusion.
Toll-like receptors, cytokines & nitric oxide synthase in patients with otitis media with effusion.
[Effect of nitric oxide and nitric oxide synthase on sensorineural hearing loss secondary to secretory otitis media]
Ototoxicity
Brain-derived neurotrophic factor and nitric oxide synthase inhibitor protect the vestibular organ against gentamicin ototoxicity.
Neuroprotection of vestibular sensory cells from gentamicin ototoxicity obtained using nitric oxide synthase inhibitors, reactive oxygen species scavengers, brain-derived neurotrophic factors and calpain inhibitors.
[Effect of injectio Salvia Miltiorrhiza on gentamicin ototoxicity-induced activity of nitric oxide synthase in cochlear stria vascularis of guinea pig].
[Effects of salvia miltiorrhiza injection on gentamicin-induced expression of nitric oxide synthase isoforms in guinea pig cochlea].
Ovarian Neoplasms
Cisplatin alters nitric oxide synthase levels in human ovarian cancer cells: involvement in p53 regulation and cisplatin resistance.
Different expression patterns of nitric oxide synthase isozymes in various gynecological cancers.
Functional role of SIRT1-induced HMGB1 expression and acetylation in migration, invasion and angiogenesis of ovarian cancer.
Nitric oxide synthase activity in fresh cells from ovarian tumour tissue: relationship of enzyme activity with clinical parameters of patients with ovarian cancer.
The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer.
Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
[The study of nitric oxide synthase in ovary tumor]
Pancreatic Neoplasms
Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line.
Other risk factors for pancreatic cancer: hormonal aspects.
Roles of nitric oxide synthase inhibition and vascular endothelial growth factor receptor-2 inhibition on vascular morphology and function in an in vivo model of pancreatic cancer.
Pancreatitis
Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs.
Association of Asymmetric Dimethylarginine With Acute Pancreatitis-Induced Hyperglycemia.
Cardiovascular homeostasis in hypotension associated with initial stages of severe acute pancreatitis.
Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein-induced rat acute pancreatitis, depending on the severity.
Effects of nitric oxide synthase inhibitors on retrograde bile salt-induced pancreatitis rats.
Expression of nitric oxide synthase isoforms and nitric oxide production in acute pancreatitis and associated lung injury.
First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.
Heparin and nitric oxide treatment in experimental acute pancreatitis in rats.
Increased proportion of nitric oxide synthase immunoreactive neurons in rat ileal myenteric ganglia after severe acute pancreatitis.
Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein.
Induction of nitric oxide synthase is a key determinant of progression to pulmonary injury in experimental pancreatitis.
Modulation of endogenous nitric oxide synthase in experimental acute pancreatitis: role of anti-ICAM-1 and oxygen free radical scavengers.
Nitric oxide synthase inhibition reduces albumin induced lung damage in acute pancreatitis.
Organ microcirculatory disturbances in experimental acute pancreatitis. A role of nitric oxide.
Prostanoid generation in early stages of acute pancreatitis: a role for nitric oxide.
The effect of combination therapy of hyperbaric oxygen, meropenem, and selective nitric oxide synthase inhibitor in experimental acute pancreatitis.
The effects of nitric oxide synthase inhibitors on acute necrotising pancreatitis in rats.
The expression of the inducible nitric oxide synthase messenger RNA on monocytes in severe acute pancreatitis.
The role of nitric oxide in mouse cerulein-induced pancreatitis with and without lipopolysaccharide pretreatment.
Pancreatitis, Graft
Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model.
pantoate-beta-alanine ligase (amp-forming) deficiency
Prenatal diagnosis of citrullinemia and argininosuccinic aciduria: evidence for a transmission ratio distortion in citrullinemia.
Paralysis
Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy.
Normalization of supine blood pressure after nitric oxide synthase inhibition in persons with tetraplegia.
Oxytocin-induced stimulation and inhibition of bladder activity in normal, conscious rats--influence of nitric oxide synthase inhibition.
Parasitemia
Effects of age and parasitemia on nitric oxide production/leukocyte nitric oxide synthase type 2 expression in asymptomatic, malaria-exposed children.
Induction of nitric oxide synthase protects against malaria in mice exposed to irradiated Plasmodium berghei infected mosquitoes: involvement of interferon gamma and CD8+ T cells.
Mice lacking inducible nitric oxide synthase develop exacerbated hepatic inflammatory responses induced by Plasmodium berghei NK65 infection.
Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia.
Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity.
Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide.
Parasitic Diseases
Ambient temperature and dietary supplementation interact to shape mosquito vector competence for malaria.
Parathyroid Neoplasms
Nitric Oxide Synthase in Human Parathyroid Glands and Parathyroid Adenomas.
Paratuberculosis
Blocking the mitogen activated protein kinase-p38 pathway is associated with increase expression of nitric oxide synthase and higher production of nitric oxide by bovine macrophages infected with Mycobacterium avium subsp paratuberculosis.
Parkinson Disease
Age- and sex- differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson's disease.
Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro.
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease.
Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.
Identification of NO-producing and -receptive cells in mesencephalic transplants in a rat model of Parkinson's disease: a study using NADPH-d enzyme- and NOSc/cGMP immunocytochemistry.
Increases in [3H]FK-506 and [3H]L-N(G)-nitro-arginine binding in the rat brain after nigrostriatal dopaminergic denervation.
Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons.
Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease.
Neuroprotective properties of statins.
Nitric oxide synthase and neuronal vulnerability in Parkinson's disease.
Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease.
Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease.
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
Nitric oxide synthase regulation and diversity: implications in Parkinson's disease.
Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene-Pesticide Interactions in a Case-Control Study of Parkinson's Disease, California (USA).
Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease.
The effect of a promoter polymorphism on the transcription of nitric oxide synthase 1 and its relevance to Parkinson's disease.
The role of nitric oxide on visual-evoked potentials in MPTP-induced Parkinsonism in mice.
[Effects of electroacupuncture on the expressions of neuroal nitric oxide synthase and astrocyte in dentate gyrus of rats with Parkinson's disease].
Parkinsonian Disorders
Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice.
Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats.
Pemphigus
Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO.
Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase.
Penile Induration
Implications of nitric oxide synthase isoforms in the pathophysiology of Peyronie's disease.
Peptic Ulcer
Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels.
Periapical Periodontitis
Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women.
Periodontal Diseases
Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study.
Systemic use of selective iNOS inhibitor 1400W or non-selective NOS inhibitor l-NAME differently affects systemic nitric oxide formation after oral Porphyromonas gingivalis inoculation in mice.
Periodontitis
Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis.
Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study.
Effect of aminoguanidine in ligature-induced periodontitis in rats.
Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products.
Exenatide and Sitagliptin Decrease Interleukin 1?, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis.
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Nitric oxide synthase inhibition prevents alveolar bone resorption in experimental periodontitis in rats.
[Alteration mechanisms of oxidative stress at periodontal tissues of rats in a simulated periodontitis and elaborate methods of their correction].
Peripheral Arterial Disease
Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study.
Peripheral Nerve Injuries
Effect of peripheral nerve injury on cGMP and nitric oxide synthase levels in rat dorsal root ganglia: time course and coexistence.
Increased expression of neuronal nitric oxide synthase in dorsal root ganglion neurons after systemic capsaicin administration.
Modulation of NMDA receptor expression in the rat spinal cord by peripheral nerve injury and adrenal medullary grafting.
Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury.
[Effects of nitric oxide synthase inhibitor on hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury].
Peripheral Nervous System Diseases
Agmatine co-treatment attenuates allodynia and structural abnormalities in cisplatin-induced neuropathy in rats.
Lysophosphatidylcholine causes neuropathic pain via the increase of neuronal nitric oxide synthase in the dorsal root ganglion and cuneate nucleus.
Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats.
Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat.
Peritonitis
A selective inhibitor of inducible in nitric oxide synthase prolongs survival in a rat model of bacterial peritonitis: comparison with two nonselective strategies.
Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis.
Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis.
Combination treatment of parenteral arginine and nitric oxide inhibitor N(G)-nitro-L-arginine methyl ester in rats with peritonitis.
Decrease in lung nitric oxide production after peritonitis in mice with sickle cell disease.
Dose Effects of Chronically Infused Nitric Oxide Synthase Inhibitor N(G)-Nitro-L-arginine Methyl Ester on Anabolic Response and Arginine Metabolism in Rats with Subacute Peritonitis.
Effects of nitric oxide on neutrophil influx depends on the tissue: role of leukotriene B4 and adhesion molecules.
Inhibition of nitric oxide synthase reverses changes in peritoneal permeability in a rat model of acute peritonitis.
Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis.
Nitric oxide synthase isoforms play distinct roles during acute peritonitis.
Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis.
Regulation of aquaporin-1 and nitric oxide synthase isoforms in a rat model of acute peritonitis.
Role of induced nitric oxide synthase and increased NO levels in zymosan peritonitis in the rat.
The dose-dependent immunoregulatory effects of the nitric oxide synthase inhibitor n(g)-nitro-L-arginine methyl ester in rats with sub-acute peritonitis.
The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis.
Phenylketonurias
Proceedings of the International Conference on Tetrahydrobiopterin, Phenylketonuria, and Nitric Oxide Synthase, St. Moritz/Champér, Switzerland, March 23-28, 2008.
Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states.
Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse.
Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.
The effects of tetrahydrobiopterin on intracerebral hemorrhage-induced brain injury in mice.
Pheochromocytoma
Growth factor induction of nitric oxide synthase in rat pheochromocytoma cells.
L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells.
Phyllodes Tumor
Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour.
Pituitary Neoplasms
Effects of nitric oxide synthase inhibition on diethylstilbestrol-induced hyperprolactinaemia and pituitary tumourigenesis in rats.
Immunohistochemical demonstration of nitric oxide synthase (NOS) in the normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas.
Nitric oxide synthase activity in human pituitary adenomas.
The clinical and pathological significance of nitric oxide synthase in human pituitary adenomas: a comparison with MIB-1.
Plague
Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection.
Plasmacytoma
A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a newly established multiple myeloma severe combined immunodeficient mouse model.
Pleural Effusion
Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion.
Pleurisy
Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy.
Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats.
Jungia sellowii suppresses the carrageenan-induced inflammatory response in the mouse model of pleurisy.
Regulation of prostaglandin generation in carrageenan-induced pleurisy by inducible nitric oxide synthase in knockout mice.
The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat.
Pleuropneumonia
Expression of nitric oxide synthase 2 and tumor necrosis factor alpha in swine naturally infected with Actinobacillus pleuropneumoniae.
Pneumococcal Infections
Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.
Pneumonia
Asymmetric Dimethylarginine Potentiates Lung Inflammation in a Mouse Model of Allergic Asthma.
Dexamethasone impairs pulmonary defence against Pseudomonas aeruginosa through suppressing iNOS gene expression and peroxynitrite production in mice.
Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammation.
Formaldehyde induces lung inflammation by an oxidant and antioxidant enzymes mediated mechanism in the lung tissue.
Inhibition of exhaled nitric oxide production during sepsis does not prevent lung inflammation.
Molecular mechanism of T-cell control of Chlamydia in mice: role of nitric oxide in vivo.
Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice.
Pretreatment with N-nitro-L-arginine methyl ester improved oxygenation after inhalation of nitric oxide in newborn piglets with Escherichia coli pneumonia and sepsis.
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.
Redox-sensitive regulation of macrophage-inducible nitric oxide synthase expression in vitro does not correlate with the failure of apocynin to prevent lung inflammation induced by endotoxin.
Role of nitric oxide on eosinophilic lung inflammation in allergic mice.
Suppression of herpes simplex virus type 1 (HSV-1)-induced pneumonia in mice by inhibition of inducible nitric oxide synthase (iNOS, NOS2).
The arginine-arginase balance in asthma and lung inflammation.
Polycystic Kidney Diseases
Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease.
Nitric oxide synthase and polycystic kidney disease.
The expression and activity of renal nitric oxide synthase and circulating nitric oxide in polycystic kidney disease rats.
Polycystic Kidney, Autosomal Dominant
Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease.
Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease.
Human Evaluation of the Glu298Asp Polymorphism in NOS3 Gene and its Relationship with Onset age of ESRD in Iranian Patients Suffering from ADPKD.
Polycythemia Vera
VEGF Regulation of Angiogenic Factors via Inflammatory Signaling in Myeloproliferative Neoplasms.
Polyneuropathies
[Expression of NADPH-diaphorase in the peripheral nerve and its changes at different stages of diphtheritic polyneuropathy]
[The ultrastructural localization of NO-synthase NADPH diaphorase in a peripheral nerve and its change in diphtheritic polyneuropathy]
Porphyrias
Mice brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs.
Porphyrias, Hepatic
Inhibition of nitric oxide synthase isoforms by porphyrins.
Post-Exercise Hypotension
Effect of systemic nitric oxide synthase inhibition on postexercise hypotension in humans.
Post-Traumatic Headache
Trigeminal Pain Molecules, Allodynia, and Photosensitivity Are Pharmacologically and Genetically Modulated in a Model of Traumatic Brain Injury.
Postural Orthostatic Tachycardia Syndrome
Cutaneous Constitutive Nitric Oxide Synthase Activation in Postural Tachycardia Syndrome with Splanchnic Hyperemia.
Pouchitis
Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: effects of probiotic treatment.
Expression of inducible and endothelial nitric oxide synthases in pouchitis.
Pre-Eclampsia
Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies.
Adrenomedullin attenuates the hypertension in hypertensive pregnant rats induced by N(G)-nitro-L-arginine methyl ester.
Animal models of preeclampsia.
Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications.
Associations between nitric oxide synthase 3 gene polymorphisms and preeclampsia risk: a meta-analysis.
Correlation of thioredoxin reductase (TrxR) and nitric oxide synthase (NOS) activities with serum trace elements in preeclampsia.
Different effects of different phosphodiesterase type-5 inhibitors in pre-eclampsia.
Differential mechanisms of endothelium-dependent vasodilator responses in human myometrial small arteries in normal pregnancy and pre-eclampsia.
Differential nitric oxide synthase activity in human platelets during normal pregnancy and pre-eclampsia.
Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study.
Effect of asymmetric dimethyl arginine on nitric oxide synthase activity in normal and pre-eclamptic placentae.
Effect of nitric oxide synthase inhibition on cardiovascular and hormonal regulation during pregnancy in the rat.
Effect of quercetine and glutathione on the level of superoxide dismutase, catalase, malonyldialdehyde, blood pressure and neonatal outcome in a rat model of pre-eclampsia induced by NG-nitro-L-arginine-methyl ester.
Effects of lipoproteins from pre-eclamptic women on umbilical endothelial cell 6-oxo-prostaglandin f1alpha and endothelin 1 synthesis, and nitric oxide synthase 3 mRNA expression.
Effects of preeclampsia-like symptoms at early gestational stage on feto-placental outcomes in a mouse model.
Electrolytes and pH changes in pre-eclamptic rats.
Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants.
Flow-mediated vasodilatation is enhanced in normal pregnancy but reduced in preeclampsia.
Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by l-NAME in rats.
Immunohistochemical characterization of placental nitric oxide synthase expression in preeclampsia.
Impairment of fetal endothelium-dependent relaxation in a rat model of preeclampsia by chronic nitric oxide synthase inhibition.
Inducible (type II) nitric oxide synthase in human placental villous tissue of normotensive, pre-eclamptic and intrauterine growth-restricted pregnancies.
Inhibition of nitric oxide synthase lowers fatty acid oxidation in preeclampsia-like mice at early gestational stage.
Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia.
L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species.
Levels of dimethylarginines and cytokines in mild and severe preeclampsia.
Marked variation in responses to long-term nitric oxide inhibition during pregnancy in outbred rats from two different colonies.
Nitric oxide synthase activities in placental tissue from normotensive, pre-eclamptic and growth retarded pregnancies.
Nitric oxide synthase activity and Doppler parameters in the fetoplacental and uteroplacental circulation in preeclampsia.
Nitric oxide synthase activity in placentae from women with pre-eclampsia.
Nitrotyrosine residues in placenta. Evidence of peroxynitrite formation and action.
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
Placental expression of endothelial constitutive nitric oxide synthase mRNA in pregnancy complicated by preeclampsia.
Placental malaria and pre-eclampsia through the looking glass backwards?
Placental nitric oxide synthase (NOS) activity and nitric oxide (NO) production in normal pregnancy, pre-eclampsia and eclampsia.
Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia.
Plasma from women with preeclampsia increases endothelial cell nitric oxide production.
Preeclampsia: evidence for impaired shear stress-mediated nitric oxide release in uterine circulation.
Reduction of placental nitric oxide synthase activity in pre-eclampsia.
Regulation of vascular adaptation during pregnancy and post-partum: effects of nitric oxide inhibition and steroid hormones.
Synergistic effect of renin-angiotensin system and nitric oxide synthase genes polymorphisms in pre-eclampsia.
The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia.
The eNOS gene: a candidate for the preeclampsia susceptibility locus?
The optimization of a chronic nitric oxide synthase (NOS) inhibition model of pre-eclampsia by evaluating physiological changes.
The Role of Nitric Oxide Synthase Inhibition by Asymmetric Dimethylarginine in the Pathophysiology of Preeclampsia.
The Role of Obesity in Preeclampsia.
Treatment with sildenafil prevents impairment of learning in rats born to pre-eclamptic mothers.
[Expression of endothelial nitric oxide synthase gene in placental villus of preeclampsia]
[Relationship between changes of endogenous nitric oxide synthase inhibitor and hydrolase and initiation of pre-eclampsia]
Pregnancy Complications, Infectious
Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice.
Pregnancy, Ectopic
Association between increased expression of endothelial isoform of nitric oxide synthase in the human fallopian tube and tubal ectopic pregnancy.
The regulation of nitric oxide synthase isoform expression in mouse and human fallopian tubes: potential insights for ectopic pregnancy.
Premature Birth
Genetic polymorphisms and spontaneous preterm birth.
Influence of MBL2 and NOS3 polymorphisms on spontaneous preterm birth in North East Brazil: genetics and preterm birth.
Progestational agents prevent preterm birth induced by a nitric oxide synthesis inhibitor in the mouse.
Priapism
Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation.
Primary Ovarian Insufficiency
Association of nitric oxide synthase gene polymorphisms (-786T>C, 4a4b, 894G>T) with primary ovarian insufficiency in Korean women.
Prion Diseases
Changes in the expression pattern of the nitrergic system of ovine cerebellum affected by scrapie.
Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease.
The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.
Prostatic Diseases
Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.
Prostatic Hyperplasia
An increase of neuropeptide Y but not nitric oxide synthase-immunoreactive nerves in the bladder neck from male patients with bladder neck dyssynergia.
Gene therapy strategies for urological dysfunction.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.
[Effects of soy bean isoflavone on inhibition of benign prostatic hyperplasia and the expressions of NO and NOS of rats]
Prostatic Neoplasms
Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression.
Association of endothelia nitric oxide synthase gene rs1799983 polymorphism with susceptibility to prostate cancer: a meta-analysis.
Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity.
Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study.
Expression of immunomodulating genes in prostate cancer and benign prostatic tissue.
Genetic variants within endothelial nitric oxide synthase gene and prostate cancer: a meta-analysis.
Human osteocalcin: a strong promoter for nitric oxide synthase gene therapy, with specificity for hormone refractory prostate cancer.
Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.
Nitric oxide synthase gene polymorphisms and prostate cancer risk.
Protein Deficiency
Maternal dietary protein deficiency decreases nitric oxide synthase and ornithine decarboxylase activities in placenta and endometrium of pigs during early gestation.
Proteinuria
Arginine as an exacerbating factor for glomerulonephritis in rats fed a methionine-threonine-supplemented low casein diet.
Co-administration of ezetimibe enhances proteinuria-lowering effects of pitavastatin in chronic kidney disease patients partly via a cholesterol-independent manner.
Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria.
Effect of nitric oxide synthase inhibition on proteinuria in glomerular immune injury.
Effect of quercetine and glutathione on the level of superoxide dismutase, catalase, malonyldialdehyde, blood pressure and neonatal outcome in a rat model of pre-eclampsia induced by NG-nitro-L-arginine-methyl ester.
Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats.
L-arginine reverses the adverse pregnancy changes induced by nitric oxide synthase inhibition in the rat.
Losartan-sensitive renal damage caused by chronic NOS inhibition does not involve increased renal angiotensin II concentrations.
Marked variation in responses to long-term nitric oxide inhibition during pregnancy in outbred rats from two different colonies.
Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids.
Regulation of vascular adaptation during pregnancy and post-partum: effects of nitric oxide inhibition and steroid hormones.
Renal kallikrein-kinin system damage and salt sensitivity: insights from experimental models.
Role of the eNOS-NO System in Regulating the Antiproteinuric Effects of VEGF Receptor 2 Inhibition in Diabetes.
Pseudomonas Infections
Effect of inhibition of nitric oxide synthase on Pseudomonas aeruginosa infection of respiratory mucosa in vitro.
Pseudorabies
Co-localization of NOS and NMDA receptor in esophageal premotor neurons of the rat.
Localization of nitric oxide synthase in the brain stem neural circuit controlling esophageal peristalsis in rats.
Neural circuitry of the kidney: NO-containing neurons.
Pseudorabies virus induces a rapid up-regulation of nitric oxide synthases in the nervous system of swine.
Pseudorabies virus-induced expression of nitric oxide synthase isoforms.
Psoriasis
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics.
Candidate gene polymorphisms and risk of psoriasis: A pilot study.
Detection of nitric oxide and nitric oxide synthases in psoriasis.
Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis.
Pulmonary Arterial Hypertension
Inhibition of nitric oxide synthase unmasks vigorous vasoconstriction in established pulmonary arterial hypertension.
The role of endothelial nitric oxide synthase expression in the development of pulmonary hypertension in chronically hypoxic infant swine.
[Role of nitric oxide in cholecystokinin octapeptide alleviation of tumor necrosis factor alpha induced changes in rabbit pulmonary arterial reactivity]
Pulmonary Disease, Chronic Obstructive
Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment.
Chronic endurance exercise induces quadriceps nitrosative stress in patients with severe COPD.
Direct effect of cigarette smoke on human pulmonary artery tension.
Expression of Nitric Oxide Synthase Isoenzyme in Lung Tissue of Smokers with and without Chronic Obstructive Pulmonary Disease.
Increased brachial intima-media thickness is associated with circulating levels of asymmetric dimethylarginine in patients with COPD.
NF-kappaB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight.
Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease.
Nitric Oxide Synthase Isoenzyme Expression and Activity in Peripheral Lungs of COPD Patients.
Nitric oxide synthase isoforms in lung parenchyma of patients with chronic obstructive pulmonary disease.
Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.
Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men.
[Expressions of and the effect of smoking on vascular endothelial growth factor and induced nitric oxide synthase in lung tissues of chronic obstructive pulmonary disease patients]
Pulmonary Edema
Decrease of asymmetric dimethylarginine predicts acute mountain sickness.
Effects of pneumonectomy on nitric oxide synthase expression and perivascular edema in the remaining lung of rats.
Hyperglycemia increased the responsiveness of isolated rabbit's pulmonary arterial rings to serotonin.
Inhibition of fibrin-induced neurogenic pulmonary edema by previous unilateral left-vagotomy correlates with increased levels of brain nitric oxide synthase in the nucleus tractus solitarii of rats.
Nitric oxide as a mediator of oxidant lung injury due to paraquat.
Polymorphisms of angiotensin converting enzyme and nitric oxide synthase 3 genes as risk factors of high-altitude pulmonary edema: a case-control study and meta-analysis.
Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: A systematic review.
Structural and functional alterations of nitric oxide synthase 3 due to missense variants associate with high-altitude pulmonary edema through dynamic study.
Pulmonary Fibrosis
Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice.
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.
Sevoflurane inhibits cardiac function in pulmonary fibrosis mice through the TLR4 signaling pathway.
[The effect of aminoguanidine, a nitric oxide synthase inhibitor, on bleomycin-induced lung injury in rats]
Pulpitis
Action of nitric oxide on healthy and inflamed human dental pulp tissue.
Histochemical observation of nitric oxide synthase in trigeminal ganglion of rats with experimental pulpitis.
Nitric oxide synthase in healthy and inflamed human dental pulp.
Pyloric Stenosis
Immunochemical characterization of neural cell adhesion molecule (NCAM), nitric oxide synthase, and neurofilament protein expression in pyloric muscle of patients with pyloric stenosis.
Nitric oxide synthase is absent in only a subset of cases of pyloric stenosis.
Pyloric Stenosis, Hypertrophic
A possible role of the plasmalemmal cytoskeleton, nitric oxide synthase, and innervation in infantile hypertrophic pyloric stenosis.
A possible role of the plasmalemmal cytoskeleton, nitric oxide synthase, and innervation in infantile hypertrophic pyloric stenosis. A confocal laser scanning microscopic study.
Nitric oxide in the peripheral nervous system.
Nitric oxide synthase activity in infantile hypertrophic pyloric stenosis.
Nonfatal congenital alveolar dysplasia due to abnormalities of NO synthase isoforms.
Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats.
[Role of nitric oxide synthase in the etiopathogenesis of hypertrophic pyloric stenosis in infants]
Quadriplegia
Direct and reflexive effects of nitric oxide synthase inhibition on blood pressure.
Effects of acute nitric oxide synthase inhibition on lower leg vascular function in chronic tetraplegia.
Normalization of supine blood pressure after nitric oxide synthase inhibition in persons with tetraplegia.
Orthostatic responses to nitric oxide synthase inhibition in persons with tetraplegia.
Rabies
Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.
Radicular Cyst
Production of human-inducible nitric oxide synthase in radicular cysts.
Rectal Neoplasms
Longitudinal muscle shows abnormal relaxation responses to nitric oxide and contains altered levels of NOS1 and elastin in uncomplicated diverticular disease.
Renal Insufficiency
Asymmetrical dimethylarginine is related to renal function, chronic inflammation and macroangiopathy in patients with Type 2 diabetes and albuminuria.
Effect of asymmetric dimethylarginine on osteoblastic differentiation.
Effects of Agmatine on Contrast-Induced Nephropathy in Rats and Rabbits.
Increased reduction of dimethylarginines and lowered interdialytic blood pressure by the use of biocompatible membranes.
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).
Reduced renal plasma clearance does not explain increased plasma asymmetric dimethylarginine in hypertensive subjects with mild to moderate renal insufficiency.
Relationship of Asymmetric Dimethylarginine With Penile Doppler Ultrasound Parameters in Men with Vasculogenic Erectile Dysfunction.
Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock.
Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy.
The protective impact of betaine on the tissue structure and renal function in isoproterenol-induced myocardial infarction in rat.
[Role of nitric oxide system in pathogenesis of experimental model of hepatorenal syndrome]
Renal Insufficiency, Chronic
5/6th nephrectomy in combination with high salt diet and nitric oxide synthase inhibition to induce chronic kidney disease in the Lewis rat.
Actin cytoskeleton-dependent pathways for ADMA-induced NF-?B activation and TGF-? high expression in human renal glomerular endothelial cells.
Arginine/asymmetric dimethylarginine ratio and cardiovascular risk factors in patients with predialytic chronic kidney disease.
Ascorbic acid: a promising agent in chronic kidney disease?
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-?1 synthesis.
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Asymmetric dimethylarginine is not a marker of arterial damage in children with glomerular kidney diseases.
Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms.
Downregulation of nitric oxide synthase in chronic renal insufficiency: role of excess PTH.
Effects of asymmetric dimethylarginine (ADMA) infusion in humans.
Elevated preoperative serum asymmetrical dimethylarginine (ADMA) is associated with poor outcomes after pediatric cardiac surgery.
Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).
Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats.
NF-?B blockade during short-term l-NAME and salt overload strongly attenuates the late development of chronic kidney disease.
Nitric Oxide in the Kidney : Its Physiological Role and Pathophysiological Implications.
Protection of wistar furth rats from chronic renal disease is associated with maintained renal nitric oxide synthase.
Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade.
Reduced nitric oxide synthase activity in rats with chronic renal disease due to glomerulonephritis.
Reduction of plasma asymmetric dimethylarginine in obese patients with chronic kidney disease after three years of a low-protein diet supplemented with keto-amino acids: a randomized controlled trial.
Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production.
Resistance to renal damage by chronic nitric oxide synthase inhibition in the Wistar-Furth rat.
The mechanism of long-term low-dose asymmetric dimethylarginine inducing transforming growth factor-? expression in endothelial cells.
Reperfusion Injury
Accounting for oxygen in the renal cortex: a computational study of factors that predispose the cortex to hypoxia.
Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusion.
Cardiac and hepatic role of r-AtHSP70: basal effects and protection against ischemic and sepsis conditions.
Changes in nitric oxide synthase levels are associated with impaired cardiac function and tolerance to ischemia-reperfusion injury in male rats with transient congenital hypothyroidism.
Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts.
Design of isoform-selective inhibitors of nitric oxide synthase.
Detection and quantification of nitric oxide (NO) synthase-independent generation of NO.
Different roles of nitric oxide synthase isoforms in cardiopulmonary resuscitation in pigs.
Effect of hyperglycemia and nitric oxide synthase inhibition on heat tolerance and induction of heat shock protein 72 kDa in vivo.
Effects and Mechanism of Action of Inducible Nitric Oxide Synthase on Apoptosis in a Rat Model of Cerebral Ischemia-Reperfusion Injury.
Effects of L-NAME and L-arginine on ischemia-reperfusion injury in rat skeletal muscle.
Effects of remote ischemic preconditioning in patients with concentric myocardial hypertrophy: A randomized, controlled trial with molecular insights.
Far red/near infrared light-induced protection against cardiac ischemia and reperfusion injury remains intact under diabetic conditions and is independent of nitric oxide synthase.
In vivo adenovirus-mediated endothelial nitric oxide synthase gene transfer ameliorates lung allograft ischemia-reperfusion injury.
Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow.
Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury?
Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors.
Melatonin attenuates renal ischemia-reperfusion injury in nitric oxide synthase inhibited rats.
Metabolic and clonogenic consequences of ischaemia reperfusion insult in solid tumours.
Moderately different NADPH-diaphorase positivity in the selected peripheral nerves after ischemia/ reperfusion injury of the spinal cord in rabbit.
Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase.
Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice.
N(G)-nitro-L-arginine methylester, a nitric oxide synthase inhibitor, diminishes apoptosis induced by ischemia-reperfusion in the rat bladder.
Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat: implications for renal transplantation.
Nitric oxide synthase in heart and thoracic aorta after liver ischemia and reperfusion injury: an experimental study in rats.
Nitric oxide synthase inhibitor, nitro-iminoethyl-L-ornithine, reduces ischemia-reperfusion injury in rabbit skeletal muscle.
Nitric oxide synthase protects the heart against ischemia-reperfusion injury in rabbits.
Nitric oxide synthase-independent generation of nitric oxide in muscle ischemia--reperfusion injury.
Platelet activating factor: the good and the bad in the ischemic/reperfused heart.
Platelet-activating factor and nitric oxide mediate microvascular permeability in ischemia-reperfusion injury.
Presence and activity of nitric oxide synthase isoforms in ischemia-reperfusion-injured flaps.
Propofol improves cardiac functional recovery after ischemia-reperfusion by upregulating nitric oxide synthase activity in the isolated rat hearts.
Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea.
Protective role of nitric oxide synthase against ischemia-reperfusion injury in guinea pig myocardial mitochondria.
Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway.
Responses of Endothelial Cells Towards Ischemic Conditioning Following Acute Myocardial Infarction.
Selenium deficiency increases the expression of inducible nitric oxide synthase in RAW 264.7 macrophages: role of nuclear factor-kappaB in up-regulation.
Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: role of endothelial cell nitric oxide synthase.
Simvastatin plus nitric oxide synthase inhibition modulates remote organ damage following skeletal muscle ischemia-reperfusion injury.
Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts.
Synergistic protective effects of antioxidant and nitric oxide synthase inhibitor in transient focal ischemia.
The dual effects of nitric oxide synthase inhibitors on ischemia-reperfusion injury in rat hearts.
The effect of hyperbaric oxygen on nitric oxide synthase activity and expression in ischemia-reperfusion injury.
The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats.
The effect of nitric oxide synthase inhibitor on reperfusion injury of the brain under hypothermic circulatory arrest.
The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes.
The endothelium in health and disease: A discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes.
The nitric oxide synthase cofactor tetrahydrobiopterin reduces allograft ischemia-reperfusion injury after lung transplantation.
The protective effect of L-arginine on ischemia-reperfusion injury in rat skin flaps.
The role of nitric oxide pathway in the renal ischemia-reperfusion injury in rats.
The role of nitric oxide synthase and heme oxygenase in the protective effect of hypothermia in ischemia-reperfusion injury.
Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways.
Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1.
[Effect of cardiomyopeptidin for injection on energy metabolism in isolated hearts of young rats after ischemia-reperfusion injury]
[Effect of electroacupuncture on nitric oxide synthase in rats with cerebral ischemia-reperfusion injury].
[Effect of electroacupuncture on plasma endogenous endothelial progenitor cell counts in cerebral ischemia-reperfusion rats]
[Effect of electroacupuncture preconditioning on nitric oxide, nitric oxide synthase and oxyradical during hepatic ischemia-reperfusion injury in rabbits].
[Effect of ischemia-reperfusion injury on the expression of nitric oxide synthase in rat retina]
[Influence of electroacupuncture on myocardial NO and NOS and intracellular Ca2+ contents in myocardial ischemia-reperfusion injury rats]
[Myocardial ischemic reperfusion injury affected by the isozymes of nitric oxide synthase and their gene expression: experimental study]
[Role of nitric oxide synthase III and guanosine 3':5'- cyclic monophosphate in the protection exerted by nitric oxide on hepatic ischemia-reperfusion injury]
[The effect of nitric oxide synthase inhibitor on reperfusion injury to the brain under hypothermic circulatory arrest]
Respiratory Distress Syndrome
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality.
Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome.
Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis.
Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice.
Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS).
Surfactant blocks lipopolysaccharide signaling by inhibiting both NF?B and PARP activation in experimental ARDS.
Respiratory Distress Syndrome, Newborn
Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population.
Retinal Neovascularization
Normal vascular development in mice deficient in endothelial NO synthase: possible role of neuronal NO synthase.
Retinal Vein Occlusion
Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease.
Retinitis Pigmentosa
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Retinoblastoma
Adventitial gene transfer to arterial wall.
Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation.
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Vascular gene transfer for the treatment of restenosis and atherosclerosis.
Vascular gene transfer.
Retinopathy of Prematurity
Correlation of interactions between NOS3 polymorphisms and oxygen therapy with retinopathy of prematurity susceptibility.
The relationship of retinopathy of prematurity with brain-derivated neurotrophic factor, vascular endotelial growth factor-A, endothelial PAD domain protein 1 and nitric oxide synthase 3 gene polymorphisms.
Rheumatic Diseases
Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases.
Rheumatic Heart Disease
Lack of association between endothelial constitutive nitric oxide synthase (ecNOS 4 b/a) gene polymorphism and rheumatic heart disease.
Rhinitis
Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects.
[Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyps]
Rhinitis, Allergic
Increased nitric oxide production in nasal epithelial cells from allergic patients--RT-PCR analysis and direct imaging by a fluorescence indicator: DAF-2 DA.
[Expression of cell adhesion molecule and nitric oxide synthase in nasal mucosa in allergic rhinitis]
Rhinitis, Vasomotor
Ultracytochemical localization of the NADPH-d activity in the human nasal respiratory mucosa in vasomotor rhinitis.
Rickettsia Infections
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis.
Sarcoma
Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways.
Sarcoma, Avian
Neural nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of rapamycin and focal adhesion kinase.
Sarcopenia
Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia.
Schistosomiasis
Inhibition of nitric oxide synthase activity reduces liver injury in murine schistosomiasis.
Scleroderma, Systemic
Abnormalities in endothelial form of nitric oxide synthase is pathogenic in limited cutaneous systemic sclerosis.
Morphometric evaluation of nitric oxide synthase isoforms and their cytokine regulators predict pulmonary dysfunction and survival in systemic sclerosis.
Scrapie
Changes in the expression pattern of the nitrergic system of ovine cerebellum affected by scrapie.
Comparison of NADPH diaphorase activity in the brains of hamsters infected with scrapie strains 139H or 263K or with normal hamster brain homogenate.
Seizures
7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats.
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
A role of nitric oxide in organophosphate-induced convulsions.
Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice.
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
alpha-Guanidinoglutaric acid as a free radical generator.
Amygdala kindling alters N-methyl-D-aspartate receptor subunit messenger RNA expression in the rat supraoptic nucleus.
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats.
Cerebral amino acid, norepinephrine and nitric oxide metabolism in CNS oxygen toxicity.
Comparative studies on the effects of clinically used anticonvulsants on the oxidative stress biomarkers in pentylenetetrazole-induced kindling model of epileptogenesis in mice.
Crystal structure of 180 degree K of bis-3, 5-diisopropylsalicylatobisdimethylsulfoxidozinc(II) and the inhibition of seizures and polymorphonuclear leukocyte chemiluminescence.
Cysteamine eliminates nitric oxide synthase activity but is not protective to the hypoxic-ischemic neonatal rat brain.
Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsions, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.
Different effects of nitric oxide synthase inhibitors on convulsions induced by nicotine in mice.
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.
Effects of nitric oxide synthase inhibition on the cerebral circulation and brain damage during kainic acid-induced seizures in newborn rabbits.
Expression of Fos in the superior lateral subdivision of the lateral parabrachial (LPBsl) area after generalized tonic seizures in rats.
Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-?B activation-induced nitric oxide synthase II expression.
HSP70 protects rats and hippocampal neurons from central nervous system oxygen toxicity by suppression of NO production and NF-?B activation.
Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation.
Induction of NO synthase and glial acidic fibrillary protein in astrocytes in the temporal cortex of the rat with audiogenic epileptiform reactions.
Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures.
Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
Inhibition of nitric oxide synthase on brain oxygenation in anesthetized rats exposed to hyperbaric oxygen.
Intestinal inflammation alters the susceptibility to pentylenetetrazole-induced seizure in mice.
Involvement of nitric oxide and nitric oxide synthase activity in anticonvulsive action.
Kainic Acid-induced Neuronal Death is Attenuated by Aminoguanidine but Aggravated by L-NAME in Mouse Hippocampus.
L-arginine-NO pathway and CNS oxygen toxicity.
L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice.
Lithium attenuates the proconvulsant effect of adolescent social isolation stress via involvement of the nitrergic system.
Long-term L-NAME treatment potentiates the blood-brain barrier disruption during pentylenetetrazole-induced seizures in rats.
Modification of kainate-induced behavioral and electrographic seizures following inhibition of nitric oxide synthase in mice.
Morphine sensitization in the pentylenetetrazole-induced clonic seizure threshold in mice: Role of nitric oxide and ? receptors.
N omega-nitro-L-arginine methyl ester interferes with pentylenetetrazol-induced kindling and has no effect on changes in glutamate binding.
NADPH diaphorase-containing nonpyramidal cells in the rat hippocampus exhibit differential sensitivity to kainic acid.
NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice.
Nitric oxide (NO) and convulsions induced by pentylenetetrazol.
Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium.
Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex.
Nitric oxide synthase inhibition suppresses wet dog shakes and augments convulsions in rats.
Nitric oxide synthase inhibitor facilitates aminopyridine induced neocortical seizure.
Nitric oxide synthase inhibitor facilitates focal seizures induced by aminopyridine in rat.
Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy.
Organophosphate-induced brain injuries: delayed apoptosis mediated by nitric oxide.
Phosphinothricin induces epileptic activity via nitric oxide production through NMDA receptor activation in adult mice.
Role of cerebral blood flow in seizures from hyperbaric oxygen exposure.
Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.
Seizures induced by alpha-guanidinoglutaric acid, a nitric oxide synthase inhibitor, are controlled by L-arginine.
Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures.
Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide.
The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide.
The effects of coenzyme Q10 on seizures in mice: The involvement of nitric oxide.
The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro.
The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice.
The lack of effects of zinc and nitric oxide in initial state of pilocarpine-induced seizures.
The role of nitric oxide in chemically- and electrically-induced seizures in mice.
[Induction of NO-synthase and glial fibrillary acidic protein in astrocytes of the temporal cortex in rats with audiogenic epileptiform reaction]
Sepsis
A yellow light for nitric oxide synthase inhibitors in sepsis: proceed with caution.
Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis.
Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock.
Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
Adrenomedullin and Adrenomedullin Binding Protein-1 Protect Endothelium-Dependent Vascular Relaxation in Sepsis.
Adrenomedullin and adrenomedullin binding protein-1 protect endothelium-dependent vascular relaxation in sepsis.
Arginine, citrulline, and nitric oxide metabolism in sepsis.
Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice.
Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III.
Bigendothelin-1 (1-21) fragment during early sepsis modulates tau, p38-MAPK phosphorylation and nitric oxide synthase activation.
Candidemia-induced pediatric sepsis and its association with free radicals, nitric oxide, and cytokine level in host.
Cardiopulmonary effects of combined nitric oxide inhibition and inhaled nitric oxide in porcine endotoxic shock.
Cell-free hemoglobin is a marker of systemic inflammation in mouse models of sepsis: a Raman spectroscopic study.
Cerebral blood flow is not altered in sheep with Pseudomonas aeruginosa sepsis treated with norepinephrine or nitric oxide synthase inhibition.
Clinical trials in sepsis: an update.
Cognitive deficits after systemic induction of inducible nitric oxide synthase: a randomised trial in rats.
Comment to: Septic shock; current pathogenetic concepts from a clinical perspective.
Cyclic nucleotides and vasoactive intestinal peptide production in a rabbit model of Escherichia coli septicemia.
Detrimental effects of a nitric oxide synthase inhibitor (N-omega-nitro-L-arginine-methyl-ester) in a murine sepsis model.
Detrimental effects of N(omega) nitro-L-arginine methyl ester (L-NAME)in experimental Escherichia coli sepsis in the newborn piglet.
Dexamethasone blocks sepsis-induced protection of the heart from ischemia reperfusion injury.
Diaphragm sarcolemmal injury is induced by sepsis and alleviated by nitric oxide synthase inhibition.
Differences in cytokine response and induction of nitric oxide synthase in endotoxin-resistant and endotoxin-sensitive mice after intravenous gram-negative infection.
Differential effects of monoclonal antibodies to tumor necrosis factor alpha and gamma interferon on induction of hepatic nitric oxide synthase in experimental gram-negative sepsis.
Differential effects of selective and non-selective NOS inhibition on renal arginine and protein metabolism during endotoxemia in rats.
Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-?B/iNOS signaling pathway.
Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock.
Effect of nitric oxide synthase inhibition and saline administration on blood pressure and renal sodium handling during experimental sepsis in rats.
Effect of nitric oxide synthase inhibition during group B streptococcal sepsis in neonatal piglets.
Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line.
Effects of a nitric oxide synthase inhibitor in humans with septic shock.
Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock.
Effects of lipopolysaccharide on intestinal injury; potential role of nitric oxide and lipid peroxidation.
Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice.
Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection.
Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients.
Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development.
Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture.
Endothelium-dependent vasodilation in response to Pseudomonas aeruginosa lipopolysaccharide: an in vitro study on canine arteries.
Endotoxin versus bacteremia: a comparison focusing on clinical relevance.
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis.
Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats.
Functional inhibition of constitutive nitric oxide synthase in a rat model of sepsis.
Hemodynamic and cardiovascular effects of nitric oxide modulation in the therapy of septic shock.
Heterogeneity of the effects of combined nitric oxide synthase inhibition on organ perfusion in ovine sepsis.
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors.
Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase.
Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice.
Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice.
Inhibition of nitric oxide synthase does not affect survival in a rat model of abdominal sepsis.
Inhibition of nitric oxide synthase during sepsis: revival because of isoform selectivity?
Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice.
Inhibition of nitric oxide synthase in experimental gram-negative sepsis.
Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone.
Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors.
Maintenance of renal vascular reactivity contributes to acute renal failure during endotoxemic shock.
Melatonin in septic shock: Some recent concepts.
Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways.
Modulation of cyclic guanosine monophosphate production during Escherichia coli septic shock.
Modulation of systemic hemodynamics by exogenous L-arginine in normal and bacteremic sheep.
N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.
N(G)-monomethyl-L-arginine improves survival in a pig model of abdominal sepsis.
Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.
Neuronal Nitric Oxide Synthase and Its Interaction With Soluble Guanylate Cyclase Is a Key Factor for the Vascular Dysfunction of Experimental Sepsis.
Nitric oxide and endothelial permeability.
Nitric oxide in the pathogenesis of sepsis.
Nitric oxide synthase 2 enhances the survival of mice during Salmonella Typhimurium infection-induced sepsis by increasing reactive oxygen species, inflammatory cytokines and recruitment of neutrophils to the peritoneal cavity.
Nitric oxide synthase activity is increased in patients with sepsis syndrome.
Nitric oxide synthase and vascular dysfunction in sepsis: should we target nitric oxide synthase 1, nitric oxide synthase 2, both, or neither?
Nitric oxide synthase inhibition as therapy for sepsis: a decade of promise.
Nitric oxide synthase inhibition during experimental sepsis improves renal excretory function in the presence of chronically increased atrial natriuretic peptide.
Nitric oxide synthase inhibition restores hypoxic pulmonary vasoconstriction in sepsis.
Nitric oxide synthase inhibition restores vasopressor effects of norepinephrine in ovine hyperdynamic sepsis.
Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats.
Nitric oxide synthase inhibition versus norepinephrine for the treatment of hyperdynamic sepsis in sheep.
Nitric oxide synthase inhibition versus norepinephrine in ovine sepsis: effects on regional blood flow.
Nitric oxide synthase inhibitors partially inhibit oxidative stress development in the rat brain during sepsis provoked by cecal ligation and puncture.
Nitric oxide synthase isoform III gene expression in rat liver is up-regulated by lipopolysaccharide and lipoteichoic acid.
Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.
Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence.
Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis.
Presence and absence of nitric oxide synthase in sepsis.
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs.
Pretreatment with N-nitro-L-arginine methyl ester improved oxygenation after inhalation of nitric oxide in newborn piglets with Escherichia coli pneumonia and sepsis.
Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases.
Purine nucleotides reduce superoxide production by nitric oxide synthase in a murine sepsis model.
Regional intestinal blood flow and nitric oxide synthase inhibition during sepsis in the rat.
Regulation of nitric oxide synthase activity in cultured human endothelial cells: effect of antioxidants.
Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.
Selective iNOS inhibition attenuates acetylcholine- and bradykinin-induced vasoconstriction in lipopolysaccharide-exposed rat lungs.
Sepsis decreases phenylephrine- and KCl-induced aortic ring contraction and decreases the frequency of oscillations in active wall tension.
Sepsis impairs anastomotic collagen gene expression and synthesis: a possible role for nitric oxide.
Sepsis increases NOS-2 activity and decreases non-NOS-mediated acetylcholine-induced dilation in rat aorta.
Sepsis inhibits reduction of dehydroascorbic acid and accumulation of ascorbate in astroglial cultures: intracellular ascorbate depletion increases nitric oxide synthase induction and glutamate uptake inhibition.
Sepsis is associated with reciprocal expressional modifications of constitutive nitric oxide synthase (NOS) in human skeletal muscle: down-regulation of NOS1 and up-regulation of NOS3.
Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism.
Sera from patients with sepsis induce nitric oxide production in vascular smooth muscle cells.
Significance of biopterin induction in rats with postburn Staphylococcus aureus sepsis.
Temporal relationships of cytokine production in mouse non-lethal sepsis: effect of nitric oxide synthase inhibitors.
Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone.
The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).
The changes of hepatic sinusoidal microcirculation and effects of nitric oxide synthase inhibitor during sepsis.
The effects of intravenous L-arginine supplementation on systemic and pulmonary hemodynamics and oxygen utilization during group B streptococcal sepsis in piglets.
The effects of propofol on hemodynamics and renal blood flow in healthy and in septic sheep, and combined with fentanyl in septic sheep.
The impact of intrarenal nitric oxide synthase inhibition on renal blood flow and function in mild and severe hyperdynamic sepsis.
Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide.
Type II nitric oxide synthase activity is cardio-protective in experimental sepsis.
Use of nitric oxide synthase inhibitors in animal models of sepsis.
Vasoplegia in septic shock (review).
[Impact of nitric oxide synthase 3 on myocardial dysfunction of sepsis]
Severe Dengue
A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis.
Expression of Nitric Oxide Synthase and Nitric Oxide Levels in Peripheral Blood Cells and Oxidized Low-Density Lipoprotein Levels in Saliva as Early Markers of Severe Dengue.
Shock, Cardiogenic
Cardiogenic shock: basics and clinical considerations.
Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.
Expert opinion on tilarginine in the treatment of shock.
Inflammation and cardiovascular diseases: lessons that can be learned for the patient with cardiogenic shock in the intensive care unit.
L-NMMA (a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock.
Lack of benefit from nitric oxide synthase inhibition in patients with cardiogenic shock: looking for the reasons.
LINCS: L-NAME (a NO synthase inhibitor) in the treatment of refractory cardiogenic shock: a prospective randomized study.
Newer approaches to the pharmacological management of heart failure.
Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: the TRIUMPH trial.
Nitric oxide synthase inhibitors in cardiogenic shock: present and future.
Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery.
Therapeutic strategies for cardiogenic shock, 2006.
Shock, Septic
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality.
Administration of nitric oxide synthase inhibitor 546C88 in septic shock.
Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group.
Antioxidants in infection.
Bench to bedside review: therapeutic modulation of nitric oxide in sepsis-an update.
Butanolides from Machilus thunbergii and their inhibitory activity on nitric oxide synthesis in activated macrophages.
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock.
Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
Cell damage and liberation of nitric oxide synthase in rat heart induced by endotoxin administration.
Characterization of the effects of two new arginine/citrulline analogues on constitutive and inducible nitric oxide synthases in rat aorta.
Clinical trials in sepsis: an update.
Comment to: Septic shock; current pathogenetic concepts from a clinical perspective.
Design of isoform-selective inhibitors of nitric oxide synthase.
Detrimental effect of a non-selective nitric oxide synthase inhibitor on the energy state of the liver following acute endotoxemia in rabbits.
Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock.
Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock.
Differential inducible nitric oxide synthase activity in circulating neutrophils vs. mononuclears of septic shock patients.
Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta.
Effect of antileukocyte adhesion molecule antibodies, nitric oxide synthase inhibitor, and corticosteroids on endotoxin shock in mice.
Effect of inhibition of nitric oxide synthase in acute renal failure due to endotoxin shock in dogs.
Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock.
Effect of the nitric oxide inhibitor, L-N(G)-monomethylarginine, on accumulation of interleukin-6 and interleukin-8, and nuclear factor-kappaB activity in a human endothelial cell line.
Effects of a nitric oxide synthase inhibitor in humans with septic shock.
Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock.
Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock.
Effects of nitric oxide synthase inhibition on regional hemodynamics and oxygen transport in endotoxic dogs.
Effects of nitro-L-arginine on blood pressure and cardiac index in anesthetized rats: a pharmacokinetic-pharmacodynamic analysis.
Endotoxin releases a substance from the aorta that dilates an isolated arteriole by up-regulating INOS.
Experimental study of the effect of nitric oxide inhibition on mesenteric blood flow and interleukin-10 levels with a lipopolysaccharide challenge.
Expert opinion on tilarginine in the treatment of shock.
Immunovascular communication: activation and deactivation of murine endothelial cell nitric oxide synthase by cytokines.
Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.
In vivo imaging of spin-trapped nitric oxide in rats with septic shock: MRI spin trapping.
Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice.
Induction of nitric oxide synthase activity by toxic shock syndrome toxin 1 in a macrophage-monocyte cell line.
Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock.
Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells.
Intestinal and hepatic perfusion and metabolism in hypodynamic endotoxic shock. Effects of nitric oxide synthase inhibition.
Lack of endotoxin-induced hyporesponsiveness to U46619 in isolated neonatal porcine pulmonary but not mesenteric arteries.
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
Mitochondrial nitric oxide synthase participates in septic shock myocardial depression by nitric oxide overproduction and mitochondrial permeability transition pore opening.
Modulation of cyclic guanosine monophosphate production during Escherichia coli septic shock.
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.
N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.
N(omega)-nitro-L-arginine methyl ester effects on neutrophil function and bacterial clearance.
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.
Nitric oxide in sepsis-syndrome: potential treatment of septic shock by nitric oxide synthase antagonists.
Nitric oxide supports atrial function in sepsis: relevance to side effects of inhibitors in shock.
Nitric oxide synthase inhibition by L-NAME in leukocytopenic patients with severe septic shock.
Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats.
Nitric oxide synthase inhibitor increases hepatic injury with formation of oxidative DNA damage and microcirculatory disturbance in endotoxemic rats.
Nitric oxide synthase inhibitors--a mechanism-based treatment of septic shock.
Nitric oxide synthase is downregulated, while haem oxygenase is increased, in patients with septic shock.
Nitric oxide synthase is not involved in cardiac contractile dysfunction in a rat model of endotoxemia without shock.
Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock.
Non-conventional vasopressors in septic shock: effects on hepatosplanchnic blood flow.
Pharmacokinetics and steady-state tissue distribution of L- and D-isomers of nitroarginine in rats.
Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group.
Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages.
Polymerized hemoglobin restores cardiovascular and kidney function in endotoxin-induced shock in the rat.
Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview.
Protective action of amlodipine on cardiac negative inotropism induced by lipopolysaccharide in rats.
Reinforcement therapy using nitric oxide synthase inhibitors against endotoxin shock in dogs.
Reversal of hypotension induced by Vibrio vulnificus lipopolysaccharide in the rat by inhibition of nitric oxide synthase.
Reversal of refractory hypotension in septic shock by inhibitor of nitric oxide synthase.
Right man, right time, right place?--on the time course of the mediator orchestra in septic shock.
Role of endogenous nitric oxide in septic shock.
Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock.
Role of vascular nitric oxide synthase in endotoxin shock of Propionibacterium acnes-sensitized rats.
Selective versus non-selective suppression of nitric oxide synthase on regional hemodynamics in rats with or without LPS-induced endotoxemia.
Sepsis, leukocytes and nitric oxide (NO): an intricate affair.
Tetrahydrobiopterin and GTP cyclohydrolase I in a rat model of endotoxic shock: relation to nitric oxide synthesis.
The effect of nitric oxide synthase inhibition on the plasma fibrinolytic system in septic shock in rats.
The effect of vasoactive intestinal peptide (VIP) and inhibition of nitric oxide synthase on survival rate in rats exposed to endotoxin shock.
The relationship of ventricular dynamics and mitochondrial nitric oxide synthase activity in septic shock models.
The role of mitochondrial nitric oxide synthase in inflammation and septic shock.
Tissue oxygenation and hemodynamic response to NO synthase inhibition in septic shock.
Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide.
Use of nitric oxide synthase inhibitors as a novel treatment for septic shock.
Use of nitric oxide synthase inhibitors to treat septic shock: the light has changed from yellow to red.
Vasoplegia in septic shock (review).
Vasopressors to treat refractory septic shock: a narrative review.
Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages.
[Effect of nitric oxide synthase inhibitors on the changes of hemodynamic parameters and aortic tension induced by septic shock in rats].
[Inhibition of nitric oxide synthase in septic shock. Therapeutic limits and perspectives]
[Nitric oxide--a basic mediator of vasodilation and septic shock]
[The alterations of nitric oxide synthase activity of ventricular cardiac muscle of rats in two septic shock models].
Sickle Cell Trait
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
Sinusitis
Acute purulent sinusitis triggered by topical nasal nitric oxide synthase inhibition.
Skin Neoplasms
17?-Estradiol-Linked Nitro-l-arginine as Simultaneous Inducer of Apoptosis in Melanoma and Tumor-Angiogenic Vascular Endothelial Cells.
Sleep Apnea, Obstructive
Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea.
Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome.
[Effects of obstructive sleep apnea style intermittent hypoxia on endothelin-1, nitric oxide, and nitric oxide synthase in endothelium: experiment with human umbilical vein endothelial cells]
Sleep Deprivation
Sleep deprivation inhibits expression of NADPH-d and NOS while activating microglia and astroglia in the rat hippocampus.
Systemic injection of a nitric oxide synthase inhibitor suppresses sleep responses to sleep deprivation in rats.
[Expression changes of nitric oxide synthase mRNA of hypothalamus after sleep deprivation in rats]
Smith-Magenis Syndrome
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Spasm
In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism.
Increased cerebral blood flow but no reversal or prevention of vasospasm in response to L-arginine infusion after subarachnoid hemorrhage.
Spermatic Cord Torsion
Increased expression of both constitutive and inducible forms of nitric oxide synthase in the delayed phase of acute experimental testicular torsion.
Spinal Cord Compression
Beneficial effects of nitric oxide synthase inhibition on the recovery of neurological function after spinal cord injury in rats.
Spinal Cord Injuries
A combination of tumor necrosis factor-alpha and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat.
A new antioxidant compound H-290151 attenuates spinal cord injury induced expression of constitutive and inducible isoforms of nitric oxide synthase and edema formation in the rat.
Acute nitric oxide synthase inhibition and cardiac conduction in persons with spinal cord injury: a short report.
Antioxidant effect of quercetin against acute spinal cord injury in rats and its correlation with the p38MAPK/iNOS signaling pathway.
Beneficial effects of nitric oxide synthase inhibition on the recovery of neurological function after spinal cord injury in rats.
Changes in nitric oxide synthase expression in young and adult rats after spinal cord injury.
Contusive spinal cord injury evokes localized changes in NADPH-d activity but extensive changes in Fos-like immunoreactivity in the rat.
Cyclosporin-A inhibits constitutive nitric oxide synthase activity and neuronal and endothelial nitric oxide synthase expressions after spinal cord injury in rats.
Cyclosporin-A inhibits inducible nitric oxide synthase activity and expression after spinal cord injury in rats.
Dynorphin neurotoxicity induced nitric oxide synthase expression in ventral horn cells of rat spinal cord.
Early changes in nitric oxide synthase activity in atrial intramural arteries following experimental spinal cord injury in rats.
Effects of nerve graft on nitric oxide synthase, NAD(P)H oxidase, and antioxidant enzymes in chronic spinal cord injury.
Epidural Cooling Minimizes Spinal Cord Injury after Aortic Cross-clamping through Induction of Nitric Oxide Synthase.
Glucocorticoid effects on Fos immunoreactivity and NADPH-diaphorase histochemical staining following spinal cord injury.
Histochemical evidence of the increased expression of nicotinamide adenine dinucleotide phosphate-dependent diaphorase in neurons of the myenteric plexus after acute spinal cord injury in adult rats.
In which period of injury is resveratrol treatment effective: ischemia or reperfusion?
Increased expression of nitric oxide synthase interacting protein (NOSIP) following traumatic spinal cord injury in rats.
Intrathecal infusion of the nitric oxide synthase inhibitor N-methyl L-arginine after experimental spinal cord injury in guinea pigs.
Moderately different NADPH-diaphorase positivity in the selected peripheral nerves after ischemia/ reperfusion injury of the spinal cord in rabbit.
NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury.
NADPH-d and Fos reactivity in the rat spinal cord following experimental spinal cord injury and embryonic neural stem cell transplantation.
NADPH-diaphorase histochemistry during the acute cardiovascular changes after spinal cord injury in the rat.
Neurochemical plasticity of nitric oxide synthase isoforms in neurogenic detrusor overactivity after spinal cord injury.
Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway.
The role of constitutive nitric oxide synthase in pathogenesis of secondary lesion after spinal cord injury. Preliminary results.
Transitory expression of NADPH diaphorase (NOS) in axonal swellings after spinal cord injury.
[Effects of high dose of dynorphin on NMDA receptor and NOS activities in spinal cord of rats]
[The effects of nitric oxide synthase on secondary spinal cord injury: an experimental research]
Spinal Cord Ischemia
Induction of neuronal and inducible nitric oxide synthase in the motoneurons of spinal cord following transient abdominal aorta occlusion in rats.
Inhibition of nitric oxide synthesis accelerates the recovery of polysynaptic reflex potentials after transient spinal cord ischemia in cats.
Moderately different NADPH-diaphorase positivity in the selected peripheral nerves after ischemia/ reperfusion injury of the spinal cord in rabbit.
Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions.
Selective sparing of NADPH-d positive spinal cord neurons affected by ischemia.
Short-term changes of NADPH diaphorase-exhibiting neuronal pools in the spinal cord of rabbit after repeated sublethal ischemia.
The effects of N(G)-nitro-L-arginine-methyl ester on neurologic and histopathologic outcome after transient spinal cord ischemia in rabbits.
Spinal Dysraphism
Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype.
Spondylitis, Ankylosing
Xinfeng capsule improves pulmonary function in ankylosing spondylitis patients via NF-?B-iNOS-NO signaling pathway.
Squamous Cell Carcinoma of Head and Neck
?Np63?/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure.
Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma.
Does type II nitric oxide synthase expression correlate with cellular proliferation in oral squamous cell carcinoma and dysplasia?
Expression of type 2 nitric oxide synthase and p21 in oral squamous cell carcinoma.
In vitro effects of nitric oxide synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study.
NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions.
Nitric oxide synthase (NOS2/3) expression in head and neck squamous cell carcinomas in correlation with clinical patterns.
Nitric oxide synthase 2 (nos2) expression in histologically normal margins of oral squamous cell carcinoma.
Nitric oxide synthase type 3 is increased in squamous hyperplasia, dysplasia, and squamous cell carcinoma of the head and neck.
Type II nitric oxide synthase (NOS2) expression correlates with lymph node status in oral squamous cell carcinoma.
Staphylococcal Infections
Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites.
Starvation
Interferon gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum.
Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.
[Laminar distribution of the active spinal neurons during the feeding-related stereotyped movements in the rat].
Status Epilepticus
Brain stem oxidative stress and its associated signaling in the regulation of sympathetic vasomotor tone.
Changes in NADPH-diaphorase positivity induced by status epilepticus in allocortical structures of the immature rat brain.
Comparison of NADPH diaphorase histochemistry, somatostatin immunohistochemistry, and silver impregnation in detecting structural and functional impairment in experimental status epilepticus.
Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-?B activation-induced nitric oxide synthase II expression.
Inhibition of neuronal (type 1) nitric oxide synthase prevents hyperaemia and hippocampal lesions resulting from kainate-induced seizures.
NADPH diaphorase-positive cells in the brain after status epilepticus.
Nitric oxide synthase immunoreactivity in the rat hippocampus after status epilepticus induced by perforant pathway stimulation.
Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus.
Upregulation of nitric oxide synthase II contributes to apoptotic cell death in the hippocampal CA3 subfield via a cytochrome c/caspase-3 signaling cascade following induction of experimental temporal lobe status epilepticus in the rat.
Stevens-Johnson Syndrome
Nitric oxide synthase in toxic epidermal necrolysis and Stevens-Johnson syndrome.
Stomach Neoplasms
Clinical significance of the long noncoding RNA RP11-19P22.6-001 in gastric cancer.
Differential expression of nitric oxide synthase in human stomach cancer.
Expression of differential nitric oxide synthase isoforms in human normal gastric mucosa and gastric cancer tissue.
Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer.
Expression of nitric oxide synthase in gastric cancer.
Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer.
Induction of apoptosis by L-NMMA, via FKHRL1/ROCK pathway in human gastric cancer cells.
Stomach Ulcer
Association of heparin with basic fibroblast growth factor, epidermal growth factor, and constitutive nitric oxide synthase on healing of gastric ulcer in rats.
Attenuation of stress-induced gastric lesions by lansoprazole, PD-136450 and ranitidine in rats.
Basic fibroblast growth factor increases constitutive nitric oxide synthase during healing of rat gastric ulcers.
Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing.
Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers.
Involvement of Glutathione, Sulfhydryl Compounds, Nitric Oxide, Vasoactive Intestinal Peptide, and Heat-Shock Protein-70 in the Gastroprotective Mechanism of Croton cajucara Benth. (Euphorbiaceae) Essential Oil.
Role of basic fibroblast growth factor in the suppression of apoptotic caspase-3 during chronic gastric ulcer healing.
Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice.
Stomatitis, Aphthous
Serum levels of total antioxidant status, nitric oxide and nitric oxide synthase in minor recurrent aphthous stomatitis patients.
Stroke
ADMA--a Possible Marker for Early Therapeutic Outcome in Acute Stroke.
Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling.
Brain nitric oxide synthase activity in normal, hypertensive, and stroke-prone rats.
Combination therapy for ischemic stroke: potential of neuroprotectants plus thrombolytics.
Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke.
Effects of poststroke losartan versus captopril treatment on myogenic and endothelial function in the cerebrovasculature of SHRsp.
Exacerbation of blood-brain barrier breakdown, edema formation, nitric oxide synthase upregulation and brain pathology after heat stroke in diabetic and hypertensive rats. Potential neuroprotection with cerebrolysin treatment.
Expression of endothelin receptors and nitric oxide synthase in the brain of stroke-prone spontaneously hypertensive rats with cerebral apoplexy.
Extracellular Vesicle Injection Improves Myocardial Function and Increases Angiogenesis in a Swine Model of Chronic Ischemia.
High Plasma Dimethylarginine Levels are Associated with Adverse Clinical Outcome After Stroke.
Inhibition of nitric oxide synthesis improves left ventricular contractility in neonatal pigs late after cardiopulmonary bypass.
Ischemia-reperfusion-related repair deficit after oxidative stress: implications of faulty transcripts in neuronal sensitivity after brain injury.
Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights.
Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition.
Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke.
Nitric oxide synthase inhibition by L-NAME in leukocytopenic patients with severe septic shock.
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.
Oxidative Stress Induced Mitochondrial DNA Deletion as a Hallmark for the Drug Development in the Context of the Cardiovascular Diseases.
Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases.
p21ras activation following hypoxia-ischemia in the newborn rat brain is dependent on nitric oxide synthase activity but p21ras does not contribute to neurologic injury.
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery.
Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women.
Renin-angiotensin system and nitric oxide synthase gene polymorphisms in relation to stroke.
Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthase.
The effect of nitric oxide synthase inhibition on acute platelet accumulation and hemodynamic depression in a rat model of thromboembolic stroke.
The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies.
Variants within the nitric oxide synthase 1 gene are associated with stroke susceptibility.
Strongyloidiasis
Inducible nitric oxide synthase controls experimental Strongyloides infection.
Subarachnoid Hemorrhage
6-Mercaptopurine reverses experimental vasospasm and alleviates the production of endothelins in NO-independent mechanism-a laboratory study.
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats.
Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys.
Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage.
Expression of inducible nitric oxide synthase in rats following subarachnoid hemorrhage.
Increased cerebrospinal fluid concentrations of asymmetric dimethylarginine correlate with adverse clinical outcome in subarachnoid hemorrhage patients.
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
Loss of nitric oxide synthase immunoreactivity in cerebral vasospasm.
Magnesium lithospermate B alleviates the production of endothelin-1 through an NO-dependent mechanism and reduces experimental vasospasm in rats.
Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarachnoid hemorrhage.
Nitric oxide synthase in acute alteration of nitric oxide levels after subarachnoid hemorrhage.
Role of inducible nitric oxide synthase in the cerebral vasospasm after subarachnoid hemorrhage in rats.
Sunburn
Nitric oxide and peroxynitrite released by ultraviolet B-irradiated human endothelial cells are possibly involved in skin erythema and inflammation.
Supranuclear Palsy, Progressive
Inducible nitric oxide synthase (iNOS)-like immunoreactivity in argyrophilic, tau-positive astrocytes in progressive supranuclear palsy.
Syncope, Vasovagal
Nitric oxide synthase inhibition restores orthostatic tolerance in young vasovagal syncope patients.
Postsynaptic ?1-Adrenergic Vasoconstriction Is Impaired in Young Patients With Vasovagal Syncope and Is Corrected by Nitric Oxide Synthase Inhibition.
Synovitis
Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors.
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Tachycardia
Cutaneous Constitutive Nitric Oxide Synthase Activation in Postural Tachycardia Syndrome with Splanchnic Hyperemia.
Effects of nitric oxide synthase inhibition on sympathetically-mediated tachycardia.
Hemin blunts the depressant effect of chronic nicotine on reflex tachycardia via activation of central NOS/PI3K pathway in female rats.
Tachycardia, Ventricular
Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts.
Tardive Dyskinesia
Association analysis of a neural nitric oxide synthase gene polymorphism and antipsychotics-induced tardive dyskinesia in Chinese schizophrenic patients.
Role of aging and striatal nitric oxide synthase activity in an animal model of tardive dyskinesia.
Temporomandibular Joint Disorders
Cocoa-enriched diets enhance expression of phosphatases and decrease expression of inflammatory molecules in trigeminal ganglion neurons.
Tension-Type Headache
Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial.
Nitric oxide in primary headaches.
Nitric oxide synthase inhibitors for the treatment of chronic tension-type headache.
Pathophysiology of tension-type headache.
Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache.
Tetanus
Nitric oxide is required for the maintenance but not initiation of ganglionic long-term potentiation.
Thiamine Deficiency
Nitric oxide synthase activities are selectively decreased in vulnerable brain regions in thiamine deficiency.
Thrombocytopenia
Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs.
Thrombophilia
Association between use of aspirin or non-aspirin non-steroidal anti-inflammatory drugs and erectile dysfunction: A systematic review.
Thrombosis
Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice.
Asymmetrical dimethylarginine level in atrial fibrillation.
Deep vein thrombosis resolution is impaired in diet-induced type 2 diabetic mice.
Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke.
High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress.
Involvement of nitric oxide and cyclooxygenase products in photoactivation-induced microvascular occlusion.
Mature coconut water exhibits antidiabetic and antithrombotic potential via L-arginine-nitric oxide pathway in alloxan induced diabetic rats.
microRNAs regulate nitric oxide release from endothelial cells by targeting NOS3.
Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol 3-kinase/Akt-dependent heat-shock protein/endothelial nitric oxide synthase signaling.
The effect of composition, size, and solubility on acute pulmonary injury in rats following exposure to Mexico city ambient particulate matter samples.
The nitric oxide synthase 3 gene polymorphisms and their association with deep vein thrombosis in Asian Indian patients.
Thrombotic Stroke
IGF-I activity may be a key determinant of stroke risk--a cautionary lesson for vegans.
Thymoma
SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese.
Trans-cinnamaldehyde promotes nitric oxide release via the protein kinase-B /v-Akt murine thymoma viral oncogene -endothelial nitric oxide synthase pathway to alleviate hypertension in SHR.Cg-Leprcp/NDmcr rats.
Thyroid Cancer, Papillary
NITRIC OXIDE SYNTHASE ACTIVITY AND ITS CONCENTRATION IN THE TISSUES OF HUMAN THYROID CARCINOMAS.
Thyroid Neoplasms
Galactosyl derivative of N(omega)-nitro-L-arginine: study of antiproliferative activity on human thyroid follicular carcinoma cells.
Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection.
NITRIC OXIDE SYNTHASE ACTIVITY AND ITS CONCENTRATION IN THE TISSUES OF HUMAN THYROID CARCINOMAS.
Thyroid Nodule
[Cyto-inactivation instantly induced by microwave ablation on thyroid nodules].
Tinnitus
Modulating central gain in tinnitus: changes in nitric oxide synthase in the ventral cochlear nucleus.
Tonsillitis
[NADH and NADPH dehydrogenase histochemistry in the tonsils in chronic tonsillitis]
Toxoplasmosis
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii.
Trauma, Nervous System
The brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3, and induced nitric oxide synthase expressions after low-level laser therapy in an axonotmesis experimental model.
Trichinellosis
Histochemical study of the nitric oxide synthase activity in experimental trichinellosis.
Triple Negative Breast Neoplasms
Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation.
Tuberculosis
1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line.
A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis.
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue.
Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2.
Effects of aminoguanidine on latent murine tuberculosis.
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis.
Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung.
Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-gamma genes and its association with susceptibility to tuberculosis.
Identification of nitric oxide synthase as a protective locus against tuberculosis.
Isolation of bead phagosomes to study virulence function of M. tuberculosis cell wall lipids.
MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression.
Nitric oxide modulates interleukin-1beta and tumour necrosis factor-alpha synthesis, and disease regression by alveolar macrophages in pulmonary tuberculosis.
Rapid induction of mRNA for nitric oxide synthase II in rat alveolar macrophages by intratracheal administration of Mycobacterium tuberculosis and Mycobacterium avium.
Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst.
The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis.
Transfer factors as immunotherapy and supplement of chemotherapy in experimental pulmonary tuberculosis.
Tuberculosis and lung cancer. An interesting case study.
Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice.
Tuberculosis, Multidrug-Resistant
Changes in nitric oxide synthase and nitrite and nitrate serum levels in patients with or without multidrug-resistant tuberculosis undergoing the intensive phase of antituberculosis therapy.
Tuberculosis, Pulmonary
Analysis of nitric oxide synthase and nitrotyrosine expression in human pulmonary tuberculosis.
Uremia
Chronic uremia induces permeability changes, increased nitric oxide synthase expression, and structural modifications in the peritoneum.
Effect of methylguanidine, guanidine and structurally related compounds on constitutive and inducible nitric oxide synthase activity.
Experimental Chronic Renal Failure-Associated Erectile Dysfunction: Molecular Alterations in Nitric Oxide Synthase Pathway and IGF-I System.
Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.
Toward better dialysis compatibility: advances in the biochemistry and pathophysiology of the peritoneal membranes.
Ureteral Obstruction
Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo.
Enhanced expression of vsmNOS mRNA in glomeruli from rats with unilateral ureteral obstruction.
Liposome-mediated transfer of nitric oxide synthase gene improves renal function in ureteral obstruction in rats.
Nitric oxide in obstructive uropathy: role of endothelial nitric oxide synthase.
Regional expression of inducible nitric oxide synthase in the kidney in dogs with unilateral ureteral obstruction.
Renal hemodynamic and ureteral pressure changes in response to ureteral obstruction: the role of nitric oxide.
Urethral Obstruction
Effects of acute complete outlet obstruction on the NADPH-diaphorase reactivity in the intramural ganglia of the guinea pig urinary bladder: light and electron microscopic studies.
Increased NADPH-diaphorase reactivity in bladder afferent pathways following urethral obstruction in guinea pigs.
Nitric oxide synthase--its distribution and alteration in the intramural ganglia of the urinary bladder in normal and urethra-obstructed guinea pigs.
Partial urethral obstruction enhances NADPH-diaphorase activity in the monkey (Macaca fascicularis) bladder: light and electron microscopic studies.
Urethral Stricture
The distribution of neuronal and inducible nitric oxide synthase in urethral stricture formation.
Urinary Bladder Diseases
Nitric oxide synthase expression in neurogenic bladder disease: a pilot study.
Nitric oxide synthase immunoreactivity in human bladder carcinoma.
Urinary Bladder Neck Obstruction
Correlation Between Nitric Oxide and Urodynamics in Men With Bladder Outlet Obstruction.
Distribution of interstitial cells of Cajal and expression of nitric oxide synthase after experimental bladder outlet obstruction in a rat model of bladder overactivity.
Effect of detrusor overactivity on the expression of aquaporins and nitric oxide synthase in rat urinary bladder following bladder outlet obstruction.
Effects of nitric oxide inhibitors in mice with bladder outlet obstruction.
Evaluation of a rat model of functional urinary bladder outlet obstruction produced by chronic inhibition of nitric oxide synthase.
Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.
Time-dependent up-regulation of endothelin-A receptors and down-regulation of endothelin-B receptors and nitric oxide synthase binding sites in the renal medulla of a rabbit model of partial bladder outlet obstruction: potential clinical relevance.
Up-regulation of endothelin (ET(A) and ET(B)) receptors and down-regulation of nitric oxide synthase in the detrusor of a rabbit model of partial bladder outlet obstruction.
Urinary Bladder Neoplasms
Bacillus Calmette-Guerin induces long-term local formation of nitric oxide in the bladder via the induction of nitric oxide synthase activity in urothelial cells.
Endogenously formed nitric oxide modulates cell growth in bladder cancer cell lines.
Nitric oxide synthase (eNOS4a/b) gene polymorphism is associated with tumor recurrence and progression in superficial bladder cancer cases.
Nitric oxide synthase expression in human bladder cancer and its relation to angiogenesis.
The (CCTTT)n microsatellite polymorphism in the nitric oxide synthase 2 gene may influence bladder cancer pathogenesis.
Urinary Bladder, Neurogenic
Nitric oxide synthase expression in neurogenic bladder disease: a pilot study.
Urinary Retention
Effects of acute complete outlet obstruction on the NADPH-diaphorase reactivity in the intramural ganglia of the guinea pig urinary bladder: light and electron microscopic studies.
Urinary Tract Infections
Bacterial infection induces nitric oxide synthase in human neutrophils.
Induction of nitric oxide synthase with urinary tract infections.
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients.
Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections.
Uterine Cervical Neoplasms
Effect of NOS1 regulating ABCG2 expression on proliferation and apoptosis of cervical cancer cells.
Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy.
Uveitis
Cellular localisation and dynamics of nitric oxide synthase expression in the rat anterior segment during endotoxin-induced uveitis.
Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats.
Concomitant treatment with a 5-lipoxygenase inhibitor improves the anti-inflammatory effect of the inhibition of nitric oxide synthase during the early phase of endotoxin-induced uveitis in the rabbit.
Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase.
Modulation of leukocyte-endothelium interaction by nitric oxide synthase inhibitors: effects on leukocyte adhesion in endotoxin-induced uveitis.
Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis.
Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis.
Role of nitric oxide synthase isozymes in endotoxin-induced uveitis.
The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine.
Uveitis, Anterior
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Vaccinia
Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication.
Identification by electron microscopy of the maturation steps in vaccinia virus morphogenesis inhibited by the interferon-induced enzymes, protein kinase (PKR), 2-5A synthetase, and nitric oxide synthase (iNOS).
Inhibition of vaccinia virus DNA replication by inducible expression of nitric oxide synthase.
Lack of N1L gene expression results in a significant decrease of vaccinia virus replication in mouse brain.
Vagus Nerve Injuries
Axonal transport of NADPH-diaphorase and [(3)H]nitro-L-arginine binding, but not [(3)H]cGMP binding, by the rat vagus nerve.
Varicocele
A global view of the pathophysiology of varicocele.
Expression of NOS isoforms in internal spermatic veins of infertile men with varicocele.
Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction.
Nitric oxide synthase patterns in normal and varicocele testis in adolescents.
Relation of nitric oxide synthase gene (NOS3) polymorphisms to varicocele risk and post-varicocelectomy seminal oxidative stress reduction.
[Relationship of nitric oxide and nitric oxide synthase with varicocele infertility]
Varicose Veins
Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins.
Expression of constitutive nitric oxide synthase isoforms in varicose vein wall; preliminary results.
Overexpression of transforming growth factor-beta1 correlates with increased synthesis of nitric oxide synthase in varicose veins.
Vascular Diseases
Adenoviral-mediated gene transfer of nitric oxide synthase isoforms and vascular cell proliferation.
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis.
Atherosclerosis and oxidative stress.
Beyond blood pressure: the endothelium and atherosclerosis progression.
Effects of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans.
Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study.
Endothelial dysfunction in pulmonary vascular disorders.
Endothelial function and coronary artery disease.
Gene expression of nitric oxide synthase by human umbilical vein endothelial cells: the effect of fetal plasma from pregnancy with umbilical placental vascular disease.
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
GTP cyclohydrolase 1 gene 3'-UTR C+243T variant predicts worsening outcome in patients with first-onset ischemic stroke.
Human recombinant erythropoietin augments serum asymmetric dimethylarginine concentrations but does not compromise nitric oxide generation in mice.
Hyperuricemia induces endothelial dysfunction.
Hypothermia Decreases Cerebrospinal Fluid Asymmetric Dimethylarginine Levels in Traumatic Brain Injury Children.
Inflammation may be a bridge connecting hypertension and atherosclerosis.
Influence of caveolin, cholesterol, and lipoproteins on nitric oxide synthase: implications for vascular disease.
Interleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cells.
Maternal plasma from pregnant women with umbilical placental vascular disease does not affect endothelial cell mRNA expression of nitric oxide synthase.
Nitric oxide synthase: role in the genesis of vascular disease.
Nitric oxide, nitric oxide synthase, and hypertensive vascular disease.
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes.
Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury.
Tetrahydrobiopterin Inhibits PDGF-stimulated Migration and Proliferation in Rat Aortic Smooth Muscle Cells via the Nitric Oxide Synthase-independent Pathway.
[Endothelial-derived nitric oxide mediates the peripheral vasodilatory effects of amrinone in humans]
Vascular Ring
Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide.
Kang Le Xin Reduces Blood Pressure Through Inducing Endothelial-Dependent Vasodilation by Activating the AMPK-eNOS Pathway.
Marked heterogeneity of endothelin-mediated contractility and contraction dynamics in mouse renal and femoral arteries.
The Lignan (-)-Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta.
Vascular System Injuries
Deficiency of nitric oxide synthase 2 results in increased neointima formation in a mouse model of vascular injury.
Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation.
Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury.
Inhibition of Apoptotic Signaling and Neointimal Hyperplasia by Tempol and Nitric Oxide Synthase following Vascular Injury.
Nitric oxide synthase gene transfer and treatment of restenosis: from bench to bedside.
Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy.
Normal vascular development in mice deficient in endothelial NO synthase: possible role of neuronal NO synthase.
Preclinical evaluation of inducible nitric oxide synthase lipoplex gene therapy for inhibition of stent-induced vascular neointimal lesion formation.
Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries.
Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors.
Vasculitis
Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.
Higher levels of SDMA and not ADMA are associated with poorer survival of trial patients with systemic ANCA-associated vasculitis.
Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.
Vasoplegia
Extended Duration Infusion of Hydroxocobalamin for Vasoplegic Rescue in Septic Shock.
Intraoperative vasoplegia: methylene blue to the rescue!
Methylene blue and vasoplegia: who, when, and how?
Methylene blue: potential use of an antique molecule in vasoplegic syndrome during cardiac surgery.
Vasoplegia in septic shock (review).
Vasoplegia in septic shock: Do we really fight the right enemy?
Vasospasm, Intracranial
Association of an endogenous inhibitor of nitric oxide synthase with cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Loss of nitric oxide synthase immunoreactivity in cerebral vasospasm.
Nitric oxide synthase gene therapy for cardiovascular disease.
Nitric oxide synthase inhibition attenuates vasoactive response to spinal cord stimulation in an experimental cerebral vasospasm model.
Nitric oxide synthase inhibitors and cerebral vasospasm.
Role of inducible nitric oxide synthase in the cerebral vasospasm after subarachnoid hemorrhage in rats.
Venous Thromboembolism
The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans.
Venous Thrombosis
Changes in ADMA and TAFI levels after stenting in coronary artery disease patients.
The nitric oxide synthase 3 gene polymorphisms and their association with deep vein thrombosis in Asian Indian patients.
Ventilator-Induced Lung Injury
Nitric oxide synthase 3 contributes to ventilator-induced lung injury.
Ventricular Dysfunction
Myocardial dysfunction in sepsis: clinical and experimental investigations.
Ventricular Dysfunction, Left
A high-lipid diet potentiates left ventricular dysfunction in nitric oxide synthase 3-deficient mice after chronic pressure overload.
Pulmonary hypertension secondary to left ventricular dysfunction: the role of nitric oxide and endothelin-1 in the control of pulmonary vascular tone.
Ventricular Fibrillation
Effect of nitric oxide synthase modulation on resuscitation success in a swine ventricular fibrillation cardiac arrest model.
Nitric oxide synthase isoform inhibition before whole body ischemia reperfusion in pigs: vital or protective?
Vesicular Stomatitis
Mechanisms of cytokine-mediated inhibition of viral replication.
Neuronal expression of NOS-1 is required for host recovery from viral encephalitis.
Virus Diseases
Activation of type III nitric oxide synthase in astrocytes following a neurotropic viral infection.
Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.
Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis.
Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.
Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes.
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.
Induction of nitric oxide synthase during Japanese encephalitis virus infection: evidence of protective role.
Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system.
Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler's virus infection.
Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection.
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.
Role of nitric oxide synthase genes in hepatitis E virus infection.
Studies on nitric oxide synthase activity in haemocytes of shrimps Fenneropenaeus chinensis and Marsupenaeus japonicus after white spot syndrome virus infection.
Vitiligo
Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo.
Inflammation drives nitric oxide synthase 2 expression by ?? T cells and affects the balance between melanoma and vitiligo associated melanoma.
Lipopolysaccharide and cytokines induce nitric oxide synthase and produce nitric oxide in cultured normal human melanocytes.
Whooping Cough
A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells.
Alterations in inotropy, nitric oxide and cyclic GMP synthesis, protein phosphorylation and ADP-ribosylation in the endotoxin-treated rat myocardium and cardiomyocytes.
Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway.
Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery.
Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices.
Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.
Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear.
Pertussis toxin-sensitive G proteins influence nitric oxide synthase III activity and protein levels in rat heart.
Regulation of cardiac ?3-adrenergic receptors in hyperglycemia.
Role of cholinergic neurons in the motor effects of glucagon-like peptide-2 in mouse colon.
Testosterone rapidly increases Ca(2+)-activated K(+) currents causing hyperpolarization in human coronary artery endothelial cells.
Time-dependent vascular actions of cannabidiol in the rat aorta.
Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors.