Reference on EC 1.6.5.2 - NAD(P)H dehydrogenase (quinone)
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Skelly, J.V.; Suter, D.A.; Knox, R.J.; Garman, E.; Stuart, D.I.; Sanderson, M.R.; Roberts, J.J.; Neidle, S.
Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line
J. Mol. Biol.
205
623-624
1989
Rattus norvegicus
Sharkis, D.H.; Swenson, R.P.
Purification by cibacron blue F3GA dye affinity chromatography and comparison of NAD(P)H:quinone reductase (E.C.1.6.99.2) from rat liver cytosol and microsomes
Biochem. Biophys. Res. Commun.
161
434-441
1989
Rattus norvegicus
Matsushita, K.; Otofuji, A.; Iwahashi, M.; Toyama, H.; Adachi, O.
NADH dehydrogenase of Corynebacterium glutamicum. Purification of an NADH dehydrogenase II homolog able to oxidize NADPH
FEMS Microbiol. Lett.
204
271-276
2001
Corynebacterium glutamicum
Giuditta, A.; Strecker, H.J.
Purification and some properties of a brain diaphorase
Biochim. Biophys. Acta
48
10-19
1961
Bos taurus
Wosilait, W.D.
The reduction of vitamin K1 by an enzyme from dog liver
J. Biol. Chem.
235
1196-1201
1960
Canis lupus familiaris
Di Prisco, G.; Casola, L.; Giuditta, A.
Purification and properties of a soluble reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase from the hepatopancreas of Octopus vulgaris
Biochem. J.
105
455-460
1967
Octopus vulgaris
Märki, F.; Martius, C.
Vitamin K-Reduktase, Darstellung und eigenschaften
Biochem. Z.
333
111-135
1960
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa, Tinca vulgaris, Xenopus laevis
-
Petitdemange, H.; Marczak, R.; Raval, G.; Gay, R.
Menadione reductase from Clostridium tyrobutyricum
Can. J. Microbiol.
26
324-329
1980
Clostridium tyrobutyricum
Rase, B.; Bartfai, T.; Ernster, L.
Purification of DT-diaphorase by affinity chromatography. Occurrence of two subunits and nonlinear Dixon and Scatchard plots of the inhibition by anticoagulants
Arch. Biochem. Biophys.
172
380-386
1976
Rattus norvegicus
Prestera, T.; Prochaska, H.J.; Talalay, P.
Inhibition of NAD(P)H:(quinone-acceptor) oxidoreductase by cibacron blue and related anthraquinone dyes: a structure-activity study
Biochemistry
31
824-833
1992
Rattus norvegicus
Segura-Aguilar, J.; Kaiser, R.; Lind, C.
Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol
Biochim. Biophys. Acta
1120
33-42
1992
Rattus norvegicus
Deng, P.S.K.; Zhao, S.H.; Iyanagi, T.; Chen, S.
Photodependent inhibition of rat liver NAD(P)H:quinone acceptor oxidoreductase by (A)-2-azido-NAD+ and (A)-8-azido-NAD
Biochemistry
30
6942-6948
1991
Rattus norvegicus
Cloete, F.; Viljoen, C.C.; Scott, W.E.; Oosthuizen, M.M.J.
A steady-state kinetic investigation of the mechanism of action of NAD(P)H dehydrogenase of the cyanobacterium, Microcystis aeruginosa
Biochim. Biophys. Acta
870
279-291
1986
Microcystis aeruginosa
-
Buswell, J.A.; Eriksson, K.E.
NAD(P)H dehydrogenase (quinone) from Sporotrichum pulverulentum
Methods Enzymol.
161
271-274
1988
Sporotrichum pulverulentum
Prochaska, H.J.
Purification and crystallization of rat liver NAD(P)H:(quinone-acceptor) oxidoreductase by cibacron blue affinity chromatography: identification of a new and potent inhibitor
Arch. Biochem. Biophys.
267
529-538
1988
Rattus norvegicus
Fasco, M.J.; Principe, L.M.
Vitamin K1 hydroquinone formation catalyzed by DT-diaphorase
Biochem. Biophys. Res. Commun.
104
187-192
1982
Rattus norvegicus
Prochaska, H.J.; Talalay, P.
Purification and characterization of two isofunctional forms of NAD(P)H: quinone reductase from mouse liver
J. Biol. Chem.
261
1372-1378
1986
Mus musculus
Amzel, L.M.; Bryant, S.H.; Prochaska, H.J.; Talalay, P.
Preliminary crystallographic X-ray data for an NAD(P)H:quinone reductase from mouse liver
J. Biol. Chem.
261
1379
1986
Mus musculus
Lind, C.; Cadenas, E.; Hochstein, P.; Ernster, L.
DT-diaphorase: purification, properties, and function
Methods Enzymol.
186
287-301
1990
Bos taurus, Rattus norvegicus
Viljoen, C.C.; Cloete, F.; Botes, D.P.; Kruger, H.
Isolation and characterization of NAD(P)H-dehydrogenases from seeds of the castor bean
Phytochemistry
22
365-370
1983
Ricinus communis
-
Lanyi, J.K.
Studies of the electron transport chain of extremely halophilic bacteria. VII. Solubilization properties of menadione reductase
J. Biol. Chem.
247
3001-3007
1972
Halobacterium salinarum
Constam, D.; Muheim, A.; Zimmermann, W.; Fiechter, A.
Purification and partial characterization of an intracellular NADH:quinone oxidoreductase from Phanerochaete chrysosporium
J. Gen. Microbiol.
137
2209-2214
1991
Phanerodontia chrysosporium
-
Wallin, R.
Some molecular properties of NAD(P)H dehydrogenase from rat liver
Biochem. J.
181
127-135
1979
Rattus norvegicus
Chen, S.; Clarke, P.E.; Martino, P.A.; Deng, P.S.K.; Yeh, C.H.; Lee, T.D.; Prochaska, H.J.; Talalay, P.
Mouse liver NAD(P)H:quinone acceptor oxidoreductase: protein sequence analysis by tandem mass spectrometry, cDNA cloning, expression in Escherichia coli, and enzyme activity analysis
Protein Sci.
3
1296-1304
1994
Homo sapiens, Mus musculus, Rattus norvegicus
Rescigno, A.; Sollai, F.; Masala, S.; Porcu, M.C.; Sanjust, E.; Rinaldi, A.C.; Curreli, N.; Grifi, D.; Rinaldi, A.
Purification and characterization of an NAD(P)H:quinone oxidoreductase from Glycine max seedlings
Prep. Biochem.
25
57-67
1995
Glycine max
Li, R.; Bianchet, M.A.; Talalay, P.; Amzel, L.M.
The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction
Proc. Natl. Acad. Sci. USA
92
8846-8850
1995
Rattus norvegicus
Chen, S.; Knox, R.; Lewis, A.D.; Friedlos, F.; Workman, P.; Deng, P.S.K.; Fung, M.; Ebenstein, D.; Wu, K.; Tsai, T.M.
Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes
Mol. Pharmacol.
47
934-939
1995
Homo sapiens, Mus musculus, Rattus norvegicus
Chen, S.; Deng, P.S.K.; Swiderek, K.; Li, M.; Chan, S.I.
Interaction of flavones and their bromoacetyl derivatives with NAD(P)H:quinone acceptor oxidoreductase
Mol. Pharmacol.
47
419-424
1995
Rattus norvegicus
Wu, K.; Knox, R.; Sun, X.Z.; Joseph, P.; Jaiswal, A.K.; Zhang, D.; Deng, P.S.K.; Chen, S.
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase
Arch. Biochem. Biophys.
347
221-228
1997
Homo sapiens
Wrobel, R.L.; Matvienko, M.; Yoder, J.I.
Heterologous expression and biochemical characterization of an NAD(P)H:quinone oxidoreductase from the hemiparasitic plant Triphysaria versicolor
Plant Physiol. Biochem.
40
265-272
2002
Triphysaria versicolor
-
Phillips, R.M.
Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development
Biochem. Pharmacol.
58
303-310
1999
Homo sapiens
Faig, M.; Bianchet, M.A.; Talalay, P.; Chen, S.; Winski, S.; Ross, D.; Amzel, L.M.
Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release
Proc. Natl. Acad. Sci. USA
97
3177-3182
2000
Homo sapiens (P15559), Homo sapiens, Mus musculus (Q64669), Mus musculus
Pink, J.J.; Planchon, S.M.; Tagliarino, C.; Varnes, M.E.; Siegel, D.; Boothman, D.A.
NAD(P)H:quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity
J. Biol. Chem.
275
5416-5424
2000
Homo sapiens
Jaiswal, A.K.
Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases
Arch. Biochem. Biophys.
375
62-68
2000
Rattus norvegicus
Sanchez, L.B.; Elmendorf, H.; Nash, T.E.; Muller, M.
NAD(P)H:menadione oxidoreductase of the amitochondriate eukaryote Giardia lamblia: a simpler homologue of the vertebrate enzyme
Microbiology
147
561-570
2001
Giardia intestinalis
Swann, E.; Barraja, P.; Oberlander, A.M.; Gardipee, W.T.; Hudnott, A.R.; Beall, H.D.; Moody, C.J.
Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2
J. Med. Chem.
44
3311-3319
2001
Homo sapiens
Winski, S.L.; Faig, M.; Bianchet, M.A.; Siegel, D.; Swann, E.; Fung, K.; Duncan, M.W.; Moody, C.J.; Amzel, L.M.; Ross, D.
Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches
Biochemistry
40
15135-15142
2001
Homo sapiens (P15559)
Bauer, A.K.; Faiola, B.; Abernethy, D.J.; Marchan, R.; Pluta, L.J.; Wong, V.A.; Roberts, K.; Jaiswal, A.K.; Gonzalez, F.J.; Butterworth, B.E.; Borghoff, S.; Parkinson, H.; Everitt, J.; Recio, L.
Genetic susceptibility to benzene-induced toxicity: role of NADPH:quinone oxidoreductase-1
Cancer Res.
63
929-935
2003
Mus musculus
Anusevicius, Z.; Sarlauskas, J.; Cenas, N.
Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships
Arch. Biochem. Biophys.
404
254-262
2002
Rattus norvegicus
Nemeikaite-Ceniene, A.; Sarlauskas, J.; Anusevicius, Z.; Nivinskas, H.; Cenas, N.
Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress
Arch. Biochem. Biophys.
416
110-118
2003
Rattus norvegicus
Vella, F.; Ferry, G.; Delagrange, P.; Boutin, J.A.
NRH:quinone reductase 2: an enzyme of surprises and mysteries
Biochem. Pharmacol.
71
1-12
2005
Homo sapiens (P15559)
Kutlu, M.; Suemer, S.; Oezata, A.
DT-diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase] in Gammarus pulex: Kinetics and some biochemical properties
Bull. Environ. Contam. Toxicol.
71
520-526
2003
Gammarus pulex
Stiborova, M.; Frei, E.; Sopko, B.; Sopkova, K.; Markova, V.; Lankova, M.; Kumstyrova, T.; Wiessler, M.; Schmeiser, H.H.
Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase
Carcinogenesis
24
1695-1703
2003
Homo sapiens, Rattus norvegicus
Gustafson, D.L.; Siegel, D.; Rastatter, J.C.; Merz, A.L.; Parpal, J.C.; Kepa, J.K.; Ross, D.; Long, M.E.
Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo
J. Pharmacol. Exp. Ther.
305
1079-1086
2003
Homo sapiens, Mus musculus, Rattus norvegicus
SantaCruz, K.S.; Yazlovitskaya, E.; Collins, J.; Johnson, J.; DeCarli, C.
Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease
Neurobiol. Aging
25
63-69
2004
Homo sapiens
Chareonthiphakorn, N.; Wititsuwannakul, D.; Golan-Goldhirsh, A.; Wititsuwannakul, R.
Purification and characterization of NAD(P)H quinone reductase from the latex of Hevea brasiliensis Müll.-Arg. (Euphorbiaceae)
Phytochemistry
61
123-128
2002
Hevea brasiliensis, Hevea brasiliensis Mull.-Arg.
Bello, R.I.; Kagan, V.E.; Tyurin, V.; Navarro, F.; Alcain, F.J.; Villalba, J.M.
Regeneration of lipophilic antioxidants by NAD(P)H:quinone oxidoreductase 1
Protoplasma
221
129-135
2003
Sus scrofa
Nemeikaite-Ceniene, A.; Dringeliene, A.; Sarlauskas, J.; Cenas, N.
Role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ
Acta Biochim. Pol.
52
937-941
2005
Ovis aries
Miseviciene, L.; Anusevicius, Z.; Sarlauskas, J.; Cenas, N.
Reduction of nitroaromatic compounds by NAD(P)H:quinone oxidoreductase (NQO1): the role of electron-accepting potency and structural parameters in the substrate specificity
Acta Biochim. Pol.
53
569-576
2006
Rattus norvegicus
Merker, M.P.; Audi, S.H.; Bongard, R.D.; Lindemer, B.J.; Krenz, G.S.
Influence of pulmonary arterial endothelial cells on quinone redox status: effect of hyperoxia-induced NAD(P)H:quinone oxidoreductase 1
Am. J. Physiol.
290
L607-619
2006
Bos taurus
Asher, G.; Dym, O.; Tsvetkov, P.; Adler, J.; Shaul, Y.
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol
Biochemistry
45
6372-6378
2006
Homo sapiens (P15559), Homo sapiens
Elbekai, R.H.; Duke, J.; El-Kadi, A.O.
Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+)
Cancer Lett.
246
54-62
2007
Mus musculus
Guo, W.; Reigan, P.; Siegel, D.; Zirrolli, J.; Gustafson, D.; Ross, D.
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition
Cancer Res.
65
10006-10015
2005
Homo sapiens
Lyn-Cook, B.D.; Yan-Sanders, Y.; Moore, S.; Taylor, S.; Word, B.; Hammons, G.J.
Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas
Cell Biol. Toxicol.
22
73-80
2006
Homo sapiens
Korashy, H.M.; El-Kadi, A.O.
Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper
Drug Metab. Dispos.
34
152-165
2006
Mus musculus
Han, E.H.; Hwang, Y.P.; Jeong, T.C.; Lee, S.S.; Shin, J.G.; Jeong, H.G.
Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase
FEBS Lett.
581
749-756
2007
Homo sapiens
Lee, Y.Y.; Westphal, A.H.; de Haan, L.H.; Aarts, J.M.; Rietjens, I.M.; van Berkel, W.J.
Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells
Free Radic. Biol. Med.
39
257-265
2005
Homo sapiens
van Horssen, J.; Schreibelt, G.; Bo, L.; Montagne, L.; Drukarch, B.; van Muiswinkel, F.L.; de Vries, H.E.
NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions
Free Radic. Biol. Med.
41
311-317
2006
Homo sapiens
Foppoli, C.; De Marco, F.; Blarzino, C.; Perluigi, M.; Cini, C.; Coccia, R.
Biological response of human diploid keratinocytes to quinone-producing compounds: role of NAD(P)H:quinone oxidoreductase 1
Int. J. Biochem. Cell Biol.
37
852-863
2005
Homo sapiens (P15559), Homo sapiens
Patridge, E.V.; Ferry, J.G.
WrbA from Escherichia coli and Archaeoglobus fulgidus is an NAD(P)H:quinone oxidoreductase
J. Bacteriol.
188
3498-3506
2006
Escherichia coli (P0A8G6), Escherichia coli, Archaeoglobus fulgidus (P58795), Archaeoglobus fulgidus
AbuKhader, M.; Heap, J.; De Matteis, C.; Kellam, B.; Doughty, S.W.; Minton, N.; Paoli, M.
Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex
J. Med. Chem.
48
7714-7719
2005
Homo sapiens
Guo, W.; Reigan, P.; Siegel, D.; Zirrolli, J.; Gustafson, D.; Ross, D.
The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins
Mol. Pharmacol.
70
1194-1203
2006
Homo sapiens
van der Logt, E.M.; Bergevoet, S.M.; Roelofs, H.M.; Te Morsche, R.H.; Dijk, Y.; Wobbes, T.; Nagengast, F.M.; Peters, W.H.
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer
Mutat. Res.
593
39-49
2006
Homo sapiens
Greenshields, D.L.; Liu, G.; Selvaraj, G.; Wei, Y.
Differential regulation of wheat quinone reductases in response to powdery mildew infection
Planta
222
867-875
2005
Triticum monococcum (Q5EI63), Triticum monococcum
Tsvetkov, P.; Asher, G.; Reiss, V.; Shaul, Y.; Sachs, L.; Lotem, J.
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin
Proc. Natl. Acad. Sci. USA
102
5535-5540
2005
Mus musculus
Covarrubias, V.G.; Lakhman, S.S.; Forrest, A.; Relling, M.V.; Blanco, J.G.
Higher activity of polymorphic NAD(P)H:quinone oxidoreductase in liver cytosols from blacks compared to whites
Toxicol. Lett.
164
249-258
2006
Homo sapiens
Moffit, J.S.; Aleksunes, L.M.; Kardas, M.J.; Slitt, A.L.; Klaassen, C.D.; Manautou, J.E.
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen
Toxicology
230
197-206
2007
Homo sapiens, Mus musculus, Mus musculus CD-1
Aleksunes, L.M.; Goedken, M.; Manautou, J.E.
Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury
World J. Gastroenterol.
12
1937-1940
2006
Homo sapiens
Gonzalez, C.F.; Ackerley, D.F.; Lynch, S.V.; Matin, A.
ChrR, a soluble quinone reductase of Pseudomonas putida that defends against H2O2.
J. Biol. Chem.
280
22590-22595
2005
Pseudomonas putida, Pseudomonas putida KT 2240
Hess, R.; Dietrich, F.M.
Cytochemical localization of dehydrogenase and diaphorase activity in Bacillus megaterium
J. Biophys. Biochem. Cytol.
8
546-550
1960
Priestia megaterium
Ergen, H.A.; Gormus, U.; Narter, F.; Zeybek, U.; Bulgurcuoglu, S.; Isbir, T.
Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer
Anticancer Res.
27
4107-4110
2008
Homo sapiens
Joung, E.J.; Li, M.H.; Lee, H.G.; Somparn, N.; Jung, Y.S.; Na, H.K.; Kim, S.H.; Cha, Y.N.; Surh, Y.J.
Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target
Antioxid. Redox Signal.
9
2087-2098
2007
Homo sapiens
Blanco, J.G.; Leisenring, W.M.; Gonzalez-Covarrubias, V.M.; Kawashima, T.I.; Davies, S.M.; Relling, M.V.; Robison, L.L.; Sklar, C.A.; Stovall, M.; Bhatia, S.
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer
Cancer
112
2789-2795
2008
Homo sapiens
Wang, Y.H.; Lee, Y.H.; Tseng, P.T.; Shen, C.H.; Chiou, H.Y.
Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan
J. Cancer Res. Clin. Oncol.
134
203-209
2008
Homo sapiens
Colucci, M.A.; Reigan, P.; Siegel, D.; Chilloux, A.; Ross, D.; Moody, C.J.
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity
J. Med. Chem.
50
5780-5789
2007
Homo sapiens
Hassani, M.; Cai, W.; Koelsch, K.H.; Holley, D.C.; Rose, A.S.; Olang, F.; Lineswala, J.P.; Holloway, W.G.; Gerdes, J.M.; Behforouz, M.; Beall, H.D.
Lavendamycin antitumor agents: structure-based design, synthesis, and NAD(P)H:quinone oxidoreductase 1 (NQO1) model validation with molecular docking and biological studies
J. Med. Chem.
51
3104-3115
2008
Homo sapiens (P15559), Homo sapiens
Wolfova, J.; Brynda, J.; Mesters, J.R.; Carey, J.; Grandori, R.; Smatanova, I.K.
Crystallographic study of Escherichia coli flavoprotein WrbA, a new NAD(P)H-dependent quinone oxidoreductase
Mater. Struct. Chem. Biol. Phys. Technol.
15
55-57
2008
Escherichia coli (P0A8G6)
-
Hong, Y.; Wang, G.; Maier, R.J.
The NADPH quinone reductase MdaB confers oxidative stress resistance to Helicobacter hepaticus
Microb. Pathog.
44
169-174
2008
Helicobacter hepaticus, Helicobacter hepaticus ATCC 51449
Fagerholm, R.; Hofstetter, B.; Tommiska, J.; Aaltonen, K.; Vrtel, R.; Syrjaekoski, K.; Kallioniemi, A.; Kilpivaara, O.; Mannermaa, A.; Kosma, V.M.; Uusitupa, M.; Eskelinen, M.; Kataja, V.; Aittomaeki, K.; von Smitten, K.; Heikkilae, P.; Lukas, J.; Holli, K.; Bartkova, J.; Blomqvist, C.; Bartek, J.
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Nat. Genet.
40
844-853
2008
Homo sapiens
Tijhuis, M.J.; Boerboom, A.M.; Visker, M.H.; Op den Camp, L.; Nagengast, F.M.; Tan, A.C.; Rietjens, I.M.; Kok, F.J.; Aarts, J.M.; Kampman, E.
The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population
Nutr. Cancer
60
204-215
2008
Homo sapiens, Homo sapiens (P15559)
Ahn, H.; Nam, J.W.; Seo, E.K.; Mar, W.
Induction of NAD(P)H:Quinone Reductase by Rutaecarpine Isolated from the Fruits of Evodia rutaecarpa in the Murine Hepatic Hepa-1c1c7 Cell Line
Planta Med.
74
1387-1390
2008
Mus musculus
Casalino, E.; Calzaretti, G.; Landriscina, M.; Sblano, C.; Fabiano, A.; Landriscina, C.
The Nrf2 transcription factor contributes to the induction of alpha-class GST isoenzymes in liver of acute cadmium or manganese intoxicated rats: comparison with the toxic effect on NAD(P)H:quinone reductase
Toxicology
237
24-34
2007
Rattus norvegicus
Reigan, P.; Colucci, M.A.; Siegel, D.; Chilloux, A.; Moody, C.J.; Ross, D.
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells
Biochemistry
46
5941-5950
2007
Homo sapiens (P15559), Homo sapiens
Jia, Z.; Zhu, H.; Misra, H.P.; Li, Y.
Potent induction of total cellular GSH and NQO1 as well as mitochondrial GSH by 3H-1,2-dithiole-3-thione in SH-SY5Y neuroblastoma cells and primary human neurons: protection against neurocytotoxicity elicited by dopamine, 6-hydroxydopamine, 4-hydroxy-2-no
Brain Res.
1197
159-169
2008
Homo sapiens
Korashy, H.M.; Brocks, D.R.; El-Kadi, A.O.
Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection
Cancer Lett.
258
135-143
2007
Mus musculus
Isbir, C.S.; Ergen, A.; Tekeli, A.; Zeybek, U.; Gormus, U.; Arsan, S.
The effect of NQO1 polymorphism on the inflammatory response in cardiopulmonary bypass
Cell Biochem. Funct.
26
534-538
2008
Homo sapiens
Fuentes, P.; Paris, I.; Nassif, M.; Caviedes, P.; Segura-Aguilar, J.
Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies
Chem. Res. Toxicol.
20
776-783
2007
Rattus norvegicus
Diaz-Veliz, G.; Paris, I.; Mora, S.; Raisman-Vozari, R.; Segura-Aguilar, J.
Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition
Chem. Res. Toxicol.
21
1180-1185
2008
Rattus norvegicus
Zhang, W.; Go, M.L.
Quinone reductase induction activity of methoxylated analogues of resveratrol
Eur. J. Med. Chem.
42
841-850
2007
Mus musculus
Song, C.W.; Chae, J.J.; Choi, E.K.; Hwang, T.S.; Kim, C.; Lim, B.U.; Park, H.J.
Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock
Int. J. Hyperthermia
24
161-169
2008
Homo sapiens, Mus musculus, Mus musculus C3H
Chen, C.Y.; Blumberg, J.B.
In vitro activity of almond skin polyphenols for scavenging free radicals and inducing quinone reductase
J. Agric. Food Chem.
56
4427-4434
2008
Mus musculus
Belchik, S.M.; Xun, L.
Functions of flavin reductase and quinone reductase in 2,4,6-trichlorophenol degradation by Cupriavidus necator JMP134
J. Bacteriol.
190
1615-1619
2008
Cupriavidus pinatubonensis JMP134
Augustine, L.M.; Fisher, C.D.; Lickteig, A.J.; Aleksunes, L.M.; Slitt, A.L.; Cherrington, N.J.
Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats
J. Biochem. Mol. Toxicol.
22
93-100
2008
Rattus norvegicus
Nolan, K.A.; Zhao, H.; Faulder, P.F.; Frenkel, A.D.; Timson, D.J.; Siegel, D.; Ross, D.; Burke, T.R.; Stratford, I.J.; Bryce, R.A.
Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity
J. Med. Chem.
50
6316-6325
2007
Homo sapiens (P15559), Homo sapiens
Kim, Y.J.; Choi, J.Y.; Paek, D.; Chung, H.W.
Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery
J. Toxicol. Environ. Health A
71
333-341
2008
Homo sapiens
Begleiter, A.; Hewitt, D.; Gibson, S.B.; Johnston, J.B.
Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia
Leuk. Res.
33
74-81
2008
Homo sapiens
Choi, E.K.; Terai, K.; Ji, I.M.; Kook, Y.H.; Park, K.H.; Oh, E.T.; Griffin, R.J.; Lim, B.U.; Kim, J.S.; Lee, D.S.; Boothman, D.A.; Loren, M.; Song, C.W.; Park, H.J.
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells
Neoplasia
9
634-642
2007
Homo sapiens
Sripathy, S.P.; Chaplin, L.J.; Gaikwad, N.W.; Rogan, E.G.; Montano, M.M.
hPMC2 is required for recruiting an ERbeta coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen
Oncogene
27
6376-6384
2008
Homo sapiens
Newsome, J.J.; Colucci, M.A.; Hassani, M.; Beall, H.D.; Moody, C.J.
Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1
Org. Biomol. Chem.
5
3665-3673
2007
Homo sapiens
Colucci, M.A.; Moody, C.J.; Couch, G.D.
Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential
Org. Biomol. Chem.
6
637-656
2008
Mus musculus, Rattus norvegicus, Homo sapiens (P15559), Homo sapiens
Munday, R.; Zhang, Y.; Munday, C.M.; Bapardekar, M.V.; Paonessa, J.D.
Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates
Pharm. Res.
25
2164-2170
2008
Rattus norvegicus
Lim, J.H.; Kim, K.M.; Kim, S.W.; Hwang, O.; Choi, H.J.
Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage
Pharmacol. Res.
57
325-331
2008
Rattus norvegicus
Wang, D.; Portis, A.R.
A novel nucleus-encoded chloroplast protein, PIFI, is involved in NAD(P)H dehydrogenase complex-mediated chlororespiratory electron transport in Arabidopsis
Plant Physiol.
144
1742-1752
2007
Arabidopsis thaliana
Carey, J.; Brynda, J.; Wolfova, J.; Grandori, R.; Gustavsson, T.; Ettrich, R.; Smatanova, I.K.
WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H:quinone oxidoreductases
Protein Sci.
16
2301-2305
2007
Escherichia coli
Stiborova, M.; Dracinska, H.; Mizerovska, J.; Frei, E.; Schmeiser, H.H.; Hudecek, J.; Hodek, P.; Phillips, D.H.; Arlt, V.M.
The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity
Toxicology
247
11-22
2008
Rattus norvegicus
Bianchet, M.A.; Erdemli, S.B.; Amzel, L.M.
Structure, function, and mechanism of cytosolic quinone reductases
Vitam. Horm.
78
63-84
2008
Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
Nivinskas, H.; Nemeikaite-Ceniene, A.; Maroziene, A.; Normantiene, T.; Cenas, N.
Prooxidant cytotoxicity of chromate in mammalian cells: the opposite roles of DT-diaphorase and glutathione reductase
Z. Naturforsch. C
61
889-895
2007
Ovis aries, Rattus norvegicus
Cabello, C.M.; Bair, W.B.; Bause, A.S.; Wondrak, G.T.
Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1
Biochem. Pharmacol.
78
344-354
2009
Homo sapiens
Bafana, A.; Chakrabarti, T.
Lateral gene transfer in phylogeny of azoreductase enzyme
Comput. Biol. Chem.
32
191-197
2008
Rattus norvegicus (P05982), Saccharomyces cerevisiae (Q07923), Mus musculus (Q64669), Cavia porcellus (Q8CHK7)
Fisher, N.; Warman, A.J.; Ward, S.A.; Biagini, G.A.
Type II NADH:quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays
Methods Enzymol.
456
303-320
2009
Plasmodium falciparum
Anwar-Mohamed, A.; El-Kadi, A.O.
Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells
Toxicol. Appl. Pharmacol.
236
261-269
2009
Mus musculus
Nolan, K.A.; Scott, K.A.; Barnes, J.; Doncaster, J.; Whitehead, R.C.; Stratford, I.J.
Pharmacological inhibitors of NAD(P)H quinone oxidoreductase, NQO1: structure/activity relationships and functional activity in tumour cells
Biochem. Pharmacol.
80
977-981
2010
Homo sapiens
Gonzalez-Aragon, D.; Alcain, F.J.; Ariza, J.; Jodar, L.; Barbarroja, N.; Lopez-Pedrera, C.; Villalba, J.M.
ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK
Chem. Biol. Interact.
186
174-183
2010
Homo sapiens
Nolan, K.A.; Doncaster, J.R.; Dunstan, M.S.; Scott, K.A.; Frenkel, A.D.; Siegel, D.; Ross, D.; Barnes, J.; Levy, C.; Leys, D.; Whitehead, R.C.; Stratford, I.J.; Bryce, R.A.
Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1)
J. Med. Chem.
52
7142-7156
2009
Homo sapiens (P15559), Homo sapiens
Douglas, M.; Lim, A.R.; Porter, J.R.; West, K.; Pink, M.M.; Ge, J.; Wylie, A.A.; Tibbits, T.T.; Biggs, K.; Curtis, M.; Palombella, V.J.; Adams, J.; Fritz, C.C.; Normant, E.
The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo
Mol. Cancer Ther.
8
3369-3378
2009
Homo sapiens
Adler, J.; Reuven, N.; Kahana, C.; Shaul, Y.
c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics
Mol. Cell. Biol.
30
3767-3778
2010
Homo sapiens
Murai, M.; Yamashita, T.; Senoh, M.; Mashimo, Y.; Kataoka, M.; Kosaka, H.; Matsuno-Yagi, A.; Yagi, T.; Miyoshi, H.
Characterization of the ubiquinone binding site in the alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling
Biochemistry
49
2973-2980
2010
Saccharomyces cerevisiae
Ian Menz, R.; Day, D.
Purification and characterization of a 43-kDa rotenone-insensitive NADH dehydrogenase from plant mitochondria
J. Biol. Chem.
271
23117-23120
1996
Beta vulgaris
Kim, I.K.; Yim, H.S.; Kim, M.K.; Kim, D.W.; Kim, Y.M.; Cha, S.S.; Kang, S.O.
Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli
J. Mol. Biol.
379
372-384
2008
Escherichia coli (P39315)
Zafar, M.; Tasca, F.; Gorton, L.; Patridge, E.; Ferry, J.; Nöll, G.
Tryptophan repressor-binding proteins from Escherichia coli and Archaeoglobus fulgidus as new catalysts for 1,4-dihydronicotinamide adenine dinucleotide-dependent amperometric biosensors and biofuel cells
Anal. Chem.
81
4082-4088
2009
Archaeoglobus fulgidus (O29904)
Mendoza, M.F.; Hollabaugh, N.M.; Hettiarachchi, S.U.; McCarley, R.L.
Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups
Biochemistry
51
8014-8026
2012
Homo sapiens
Zhang, W.; Go, M.L.
Methoxylation of resveratrol: effects on induction of NAD(P)H quinone-oxidoreductase 1 (NQO1) activity and growth inhibitory properties
Bioorg. Med. Chem. Lett.
21
1032-1035
2011
Homo sapiens, Mus musculus
Burke, P.J.; Wong, L.C.; Jenkins, T.C.; Knox, R.J.; Stanforth, S.P.
The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli
Bioorg. Med. Chem. Lett.
21
7447-7450
2011
Homo sapiens
Stiborova”, M.; Dracinska”, H.; Martinek, V.; Svaskova”, D.; Hodek, P.; Milichovsky, J.; Hejdukova”, Z.; Brotanek, J.; Schmeiser, H.; Frei, E.
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I)
Chem. Res. Toxicol.
26
290-299
2013
Rattus norvegicus
Bongard, R.D.; Krenz, G.S.; Gastonguay, A.J.; Williams, C.L.; Lindemer, B.J.; Merker, M.P.
Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells
Free Radic. Biol. Med.
50
953-962
2011
Bos taurus
Siegel, D.; Shieh, B.; Yan, C.; Kepa, J.K.; Ross, D.
Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells
J. Pharmacol. Exp. Ther.
336
874-880
2011
Homo sapiens
Nam, S.T.; Hwang, J.H.; Kim, D.H.; Park, M.J.; Lee, I.H.; Nam, H.J.; Kang, J.K.; Kim, S.K.; Hwang, J.S.; Chung, H.K.; Shong, M.; Lee, C.H.; Kim, H.
Role of NADH: quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells
BMB Rep.
47
494-499
2014
Mus musculus (Q64669)
Brock, B.J.; Rieble, S.; Gold, M.H.
Purification and Ccaracterization of a 1,4-benzoquinone reductase from the basidiomycete Phanerochaete chrysosporium
Appl. Environ. Microbiol.
61
3076-3081
1995
Phanerodontia chrysosporium (Q9Y763), Phanerodontia chrysosporium
Rougee, L.R.; Riches, Z.; Berman, J.M.; Collier, A.C.
The ontogeny and population variability of human hepatic NADPH dehydrogenase quinone oxido-reductase 1 (NQO1)
Drug Metab. Dispos.
44
967-974
2016
Homo sapiens, Homo sapiens (P15559)
Ramos, A.R.; Grein, F.; Oliveira, G.P.; Venceslau, S.S.; Keller, K.L.; Wall, J.D.; Pereira, I.A.
The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough
Environ. Microbiol.
17
2288-2305
2015
Desulfovibrio vulgaris (Q729F2 and Q729F1 and Q729F0), Desulfovibrio vulgaris Hildenborough (Q729F2 and Q729F1 and Q729F0)
Saroussi, S.I.; Wittkopp, T.M.; Grossman, A.R.
The type II NADPH dehydrogenase facilitates cyclic electron flow, energy-dependent quenching, and chlororespiratory metabolism during acclimation of Chlamydomonas reinhardtii to nitrogen deprivation
Plant Physiol.
170
1975-1988
2016
Chlamydomonas reinhardtii (A8JI60)
Sedlacek, V.; Klumpler, T.; Marek, J.; Kucera, I.
The structural and functional basis of catalysis mediated by NAD(P)H acceptor oxidoreductase (FerB) of Paracoccus denitrificans
PLoS ONE
9
e96262
2014
Paracoccus denitrificans (A1B9E3), Paracoccus denitrificans, Paracoccus denitrificans Pd 1222 (A1B9E3)
Maeda, T.; Tanabe-Fujimura, C.; Fujita, Y.; Abe, C.; Nanakida, Y.; Zou, K.; Liu, J.; Liu, S.; Nakajima, T.; Komano, H.
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-induced endoplasmic reticulum protein
Biochem. Biophys. Res. Commun.
473
1276-1280
2016
Mus musculus
Shrestha, A.K.; Patel, A.; Menon, R.T.; Jiang, W.; Wang, L.; Moorthy, B.; Shivanna, B.
Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice
Biochem. Biophys. Res. Commun.
485
195-200
2017
Mus musculus (Q64669)
Newsome, J.J.; Hassani, M.; Swann, E.; Bibby, J.M.; Beall, H.D.; Moody, C.J.
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones excellent substrates for NAD(P)H quinone oxidoreductase 1
Bioorg. Med. Chem.
21
2999-3009
2013
Homo sapiens (P15559), Homo sapiens
Sasaki, J.; Sano, K.; Hagimori, M.; Yoshikawa, M.; Maeda, M.; Mukai, T.
Synthesis and in vitro evaluation of radioiodinated indolequinones targeting NAD(P)H quinone oxidoreductase 1 for internal radiation therapy
Bioorg. Med. Chem.
22
6039-6046
2014
Homo sapiens (P15559), Homo sapiens
Bian, J.; Xu, L.; Deng, B.; Qian, X.; Fan, J.; Yang, X.; Liu, F.; Xu, X.; Guo, X.; Li, X.; Sun, H.; You, Q.; Zhang, X.
Synthesis and evaluation of (+-)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H quinone oxidoreductase 1 (NQO1)
Bioorg. Med. Chem. Lett.
25
1244-1248
2015
Homo sapiens (P15559)
Nagata, M.; Kimura, T.; Suzumura, T.; Kira, Y.; Nakai, T.; Umekawa, K.; Tanaka, H.; Matsuura, K.; Mitsuoka, S.; Yoshimura, N.; Oka, T.; Kudoh, S.; Hirata, K.
C609T polymorphism of NADPH quinone oxidoreductase 1 correlates clinical hematological toxicities in lung cancer patients treated with amrubicin
Clin. Med. Insights Oncol.
7
31-39
2013
Homo sapiens (P15559)
Zhang, X.; Han, K.; Yuan, D.H.; Meng, C.Y.
Overexpression of NAD(P)H quinone oxidoreductase 1 inhibits hepatocellular carcinoma cell proliferation and induced apoptosis by activating AMPK/PGC-1alpha pathway
DNA Cell Biol.
36
256-263
2017
Homo sapiens (P15559), Homo sapiens
Bian, J.; Li, X.; Xu, L.; Wang, N.; Qian, X.; You, Q.; Zhang, X.
Affinity-based small fluorescent probe for NAD(P)H quinone oxidoreductase 1 (NQO1). Design, synthesis and pharmacological evaluation
Eur. J. Med. Chem.
127
828-839
2017
Homo sapiens (P15559), Homo sapiens
Lienhart, W.D.; Gudipati, V.; Uhl, M.K.; Binter, A.; Pulido, S.A.; Saf, R.; Zangger, K.; Gruber, K.; Macheroux, P.
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H quinone oxidoreductase
FEBS J.
281
4691-4704
2014
Homo sapiens (P15559)
Lienhart, W.D.; Strandback, E.; Gudipati, V.; Koch, K.; Binter, A.; Uhl, M.K.; Rantasa, D.M.; Bourgeois, B.; Madl, T.; Zangger, K.; Gruber, K.; Macheroux, P.
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H quinone oxidoreductase 1 (NQO1)
FEBS J.
284
1233-1245
2017
Homo sapiens (P15559), Homo sapiens
Roubalova, L.; Dinkova-Kostova, A.T.; Biedermann, D.; K?en, V.; Ulrichova, J.; Vrba, J.
Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H quinone oxidoreductase 1 in Hepa1c1c7 cells
Fitoterapia
119
115-120
2017
Mus musculus (Q64669), Mus musculus
Atia, A.; Alrawaiq, N.; Abdullah, A.
Tocotrienol-rich palm oil extract induces NAD(P)H quinone oxidoreductase 1 (NQO1) expression in mice liver
J. Appl. Pharm. Sci.
6
127-134
2016
Mus musculus (Q64669)
-
Kummarapurugu, A.B.; Fischer, B.M.; Zheng, S.; Milne, G.L.; Ghio, A.J.; Potts-Kant, E.N.; Foster, W.M.; Soderblom, E.J.; Dubois, L.G.; Moseley, M.A.; Thompson, J.W.; Voynow, J.A.
NADPH quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation
J. Biol. Chem.
288
4681-4691
2013
Mus musculus (Q64669)
Jackson, S.J.; Singletary, K.W.; Murphy, L.L.; Venema, R.C.; Young, A.J.
Phytonutrients differentially stimulate NAD(P)H quinone oxidoreductase, inhibit proliferation, and trigger mitotic catastrophe in Hepa1c1c7 cells
J. Med. Food
19
47-53
2016
Mus musculus (Q64669)
Glorieux, C.; Sandoval, J.M.; Dejeans, N.; Ameye, G.; Poirel, H.A.; Verrax, J.; Calderon, P.B.
Overexpression of NAD(P)H quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones
Life Sci.
145
57-65
2016
Homo sapiens (P15559), Homo sapiens
Bang, H.; Park, S.; Saeidi, S.; Na, H.; Surh, Y.
Docosahexaenoic acid induces expression of heme oxygenase-1 and NAD(P)H Quinone oxidoreductase through activation of Nrf2 in human mammary epithelial cells
Molecules
22
E969
2017
Homo sapiens (P15559), Homo sapiens
Gayam, S.R.; Venkatesan, P.; Sung, Y.M.; Sung, S.Y.; Hu, S.H.; Hsu, H.Y.; Wu, S.P.
An NAD(P)H quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo
Nanoscale
8
12307-12317
2016
Homo sapiens
Cui, X.; Jin, T.; Wang, X.; Jin, G.; Li, Z.; Lin, L.
NAD(P)H quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer
Oncol. Rep.
32
2589-2595
2014
Homo sapiens (P15559), Homo sapiens
Okubo, A.; Yasuhira, S.; Shibazaki, M.; Takahashi, K.; Akasaka, T.; Masuda, T.; Maesawa, C.
NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol
Pigment cell Melanoma Res.
29
309-316
2016
Homo sapiens (P15559), Homo sapiens, Mus musculus (Q64669), Mus musculus
Biniek, C.; Heyno, E.; Kruk, J.; Sparla, F.; Trost, P.; Krieger-Liszkay, A.
Role of the NAD(P)H quinone oxidoreductase NQR and the cytochrome b AIR12 in controlling superoxide generation at the plasma membrane
Planta
245
807-817
2017
Arabidopsis thaliana (Q9LK88), Arabidopsis thaliana
Kasai, S.; Arakawa, N.; Okubo, A.; Shigeeda, W.; Yasuhira, S.; Masuda, T.; Akasaka, T.; Shibazaki, M.; Maesawa, C.
NAD(P)H quinone oxidoreductase-1 expression sensitizes malignant melanoma cells to the HSP90 inhibitor 17-AAG
PLoS ONE
11
e0153181
2016
Homo sapiens (P15559), Homo sapiens
Philbrook, N.A.; Winn, L.M.
Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase potential implications for fetal protection aga
Reprod. Toxicol.
43
30-37
2014
Mus musculus (Q64669)
Gray, J.P.; Karandrea, S.; Burgos, D.Z.; Jaiswal, A.A.; Heart, E.A.
NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) and cytochrome P450 oxidoreductase (CYP450OR) differentially regulate menadione-mediated alterations in redox status, survival and metabolism in pancreatic beta-cells
Toxicol. Lett.
262
1-11
2016
Rattus norvegicus (P05982)
Zhang, Y.; den Braver-Sewradj, S.P.; Vos, J.C.; Vermeulen, N.P.E.; Commandeur, J.N.M.
Human glutathione S-transferases- and NAD(P)H quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine Possible implications for susceptibility to amodiaquine-induced liver toxicity
Toxicol. Lett.
275
83-91
2017
Homo sapiens (P15559), Homo sapiens
html completed
