Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
Acidosis
The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation.
Acute Kidney Injury
NADPH oxidase 4 mediates TGF-?1/Smad signaling pathway induced acute kidney injury in hypoxia.
NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation.
Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury.
PPAR? and NAD(P)H oxidase system interaction in glycerol-induced acute renal failure: role of gp91phox subunit of NAD(P)H oxidase.
Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets.
Acute Lung Injury
Dual Oxidase 2 in Lung Epithelia Is Essential for Hyperoxia-Induced Acute Lung Injury in Mice.
Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization: comparative pharmacokinetics of nitrone-apocynin and its parent apocynin in rats.
Adenocarcinoma
Cambogin exerts anti-proliferative and pro-apoptotic effects on breast adenocarcinoma through the induction of NADPH oxidase 1 and the alteration of mitochondrial morphology and dynamics.
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
DUOX2, a New Biomarker for Disseminated Gastric Cancer's Response to Low Dose Radiation in Mice.
Expression of NOX Family Genes and Their Clinical Significance in Colorectal Cancer.
High Immunoreactivity of DUOX2 Is Associated With Poor Response to Preoperative Chemoradiation Therapy and Worse Prognosis in Rectal Cancers.
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells.
Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression.
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon.
Adenocarcinoma, Follicular
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma.
Adenoma
A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis.
Differential gene expression between flat adenoma and normal mucosa in the colon in a microarray analysis.
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon.
OXIDATIVE STRESS RELATED PROTEINS IN A CONN'S ADENOMA TISSUE. RELEVANCE FOR ALDOSTERONE'S PROOXIDATIVE AND PROINFLAMMATORY ACTIVITY.
Agammaglobulinemia
Structure-function effects in primary immunodeficiencies.
Agranulocytosis
Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis.
Albuminuria
Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.
Albuminuria, expression of nicotinamide adenine dinucleotide phosphate oxidase and monocyte chemoattractant protein-1 in the renal tubules of hypertensive Dahl salt-sensitive rats.
Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension.
Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice.
Efficacy of aliskiren, compared with angiotensin II blockade, in slowing the progression of diabetic nephropathy in db/db mice: should the combination therapy be a focus?
Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney.
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat.
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
Alzheimer Disease
Amyloid ?-induced astrogliosis is mediated by ?1-integrin via NADPH oxidase 2 in Alzheimer's disease.
NADPH-oxidase activation and cognition in Alzheimer's disease progression.
Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid.
Anemia
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease.
Infection-stimulated anemia results primarily from interferon gamma-dependent, signal transducer and activator of transcription 1-independent red cell loss.
Anemia, Iron-Deficiency
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Anemia, Sickle Cell
Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice.
Angina Pectoris
Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase.
Antiphospholipid Syndrome
Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome.
Endosomal NADPH-oxidase is critical for induction of the tissue factor gene in monocytes and endothelial cells. Lessons from the antiphospholipid syndrome.
Aortic Aneurysm
Smooth muscle NADPH oxidase 4 promotes angiotensin II-induced aortic aneurysm and atherosclerosis by regulating osteopontin.
Aortic Aneurysm, Abdominal
Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Arteritis
NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.
Arthritis
A case-control study of Rheumatoid arthritis identifies an associated SNP in the NCF4 gene supporting a role for the NOX-complex in autoimmunity.
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase.
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.
Positioning of a Polymorphic Quantitative Trait Nucleotide in the Ncf1 Gene Controlling Oxidative Burst Response and Arthritis Severity in Rats.
Redox Regulation of Pro-IL-1? Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice.
Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells.
Arthritis, Rheumatoid
Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population.
NADPH oxidase priming and p47phox phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis and spondylarthropathy.
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.
Superoxide production by polymorphonuclear leucocytes in rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase.
Synovial fluid polymorphonuclear leucocytes from patients with rheumatoid arthritis have reduced MPO and NADPH-oxidase activity.
The effect of pregnancy on polymorphonuclear leukocyte function.
Asbestosis
NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression.
Ascorbic Acid Deficiency
Phagocytosis and leukocyte enzymes in ascorbic acid deficient guinea pigs.
Aspergillosis
A Shifted Composition of the Lung Microbiota Conditions the Antifungal Response of Immunodeficient Mice.
Bronchocentric granulomatosis as a first clinical manifestation in an adult patient with p67phox deficiency.
Invasive aspergillosis in chronic granulomatous disease.
Invasive aspergillosis in primary immunodeficiencies.
Reduced nicotinamide adenine dinucleotide phosphate oxidase-independent resistance to Aspergillus fumigatus in alveolar macrophages.
Asthma
Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses.
Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model.
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.
Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization: comparative pharmacokinetics of nitrone-apocynin and its parent apocynin in rats.
NADPH oxidase 4 over-expression is associated with epithelial ciliary dysfunction in neutrophilic asthma.
Role of T cells in a gp91phox knockout murine model of acute allergic asthma.
Astrocytoma
Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis.
Ataxia Telangiectasia
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.
Atherosclerosis
A commercial extract of fruits and vegetables, Oxxynea, acts as a powerful antiatherosclerotic supplement in an animal model by reducing cholesterolemia, oxidative stress, and NADPH oxidase expression.
Active principle of kimchi, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, retards fatty streak formation at aortic sinus of apolipoprotein E knockout mice.
Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.
Anti-atherosclerotic effects of vitamin E--myth or reality?
Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.
Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells.
Cardiovascular disease and benefits of thiazolidinediones.
Cerebral vascular effects of reactive oxygen species: recent evidence for a role of NADPH-oxidase.
Coadministration of VDR and RXR agonists synergistically alleviates atherosclerosis through inhibition of oxidative stress: An in vivo and in vitro study.
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis.
Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox.
FcgammaRIIa mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4.
Flagellin-induced NADPH oxidase 4 activation is involved in atherosclerosis.
Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis.
Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction.
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis.
Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis.
Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice.
Implications of NADPH oxidase 5 in vascular diseases.
Importance of NAD(P)H oxidase-mediated oxidative stress and contractile type smooth muscle myosin heavy chain SM2 at the early stage of atherosclerosis.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
microRNA-363-3p reduces endothelial cell inflammatory responses in coronary heart disease via inactivation of the NOX4-dependent p38 MAPK axis.
NAD(P)H oxidase-induced oxidative stress in sympathetic ganglia of apolipoprotein E deficient mice.
NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis.
NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice.
NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis.
Nitric Oxide, NAD(P)H Oxidase and Atherosclerosis.
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology.
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries.
NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease.
NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis.
Oxidant stress and atherosclerosis.
Oxidant stress-a major cause of reduced endothelial nitric oxide availability in cardiovascular disease.
Oxidative stress, AGE, and atherosclerosis.
Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E.
p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells.
Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters.
Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease.
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase.
Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure.
Regression of atherosclerosis in monkeys reduces vascular superoxide levels.
Responses to reductive stress in the cardiovascular system.
Smooth muscle NADPH oxidase 4 promotes angiotensin II-induced aortic aneurysm and atherosclerosis by regulating osteopontin.
Splanchnic-aortic inflammatory axis in experimental portal hypertension.
The Effects of Dimethyl Fumarate on Atherosclerosis in the Apolipoprotein E-Deficient Mouse Model with Streptozotocin-Induced Hyperglycemia Mediated By the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element (Nrf2/ARE) Signaling Pathway.
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases.
UltraRapid communications : vascular superoxide production by NAD(P)H OxidaseAssociation with endothelial dysfunction and clinical risk factors
Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors.
Atrial Fibrillation
A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation.
Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium: A Novel Gene Therapy Approach to Atrial Fibrillation.
Autoimmune Diseases
Association of NCF2, NCF4, and CYBA Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population.
Azotemia
Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease.
NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE.
Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney.
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Bacterial Infections
Decreased STAT5 phosphorylation and GATA-3 expression in NOX2 deficient T cells: Role in T helper development.
JNK/FOXO mediated PeroxiredoxinV expression regulates redox homeostasis during Drosophila melanogaster gut infection.
NOX2 decoy peptides disrupt trauma-mediated neutrophil immunosuppression and protect against lethal peritonitis.
Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections.
Barrett Esophagus
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon.
Blast Crisis
Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia.
Bone Resorption
Loss of Functional NADPH Oxidase 2 Protects Against Alcohol-Induced Bone Resorption in Female p47phox(-/-) Mice.
Brain Edema
Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice.
NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury.
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.
Role of NADPH oxidase in the brain injury of intracerebral hemorrhage.
Brain Infarction
NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study.
The 2-(2-benzofuranyl)-2-imidazoline provides neuroprotection against focal cerebral ischemia-reperfusion injury in diabetic rats: Influence of microglia and possible mechanisms of action.
Brain Injuries
Alcohol-induced exacerbation of ischemic brain injury: role of NAD(P)H oxidase.
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice.
Oxidative-Nitrosative Stress in a Rabbit Pup Model of Germinal Matrix Hemorrhage. Role of NAD(P)H Oxidase.
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Role of NADPH oxidase in the brain injury of intracerebral hemorrhage.
Role of neuronal NADPH oxidase 1 in the peri-infarct regions after stroke.
Brain Injuries, Traumatic
An Effective NADPH Oxidase 2 Inhibitor Provides Neuroprotection and Improves Functional Outcomes in Animal Model of Traumatic Brain Injury.
Deletion of NADPH oxidase 4 reduces severity of traumatic brain injury.
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
NADPH oxidase 2 deletion enhances neurogenesis following traumatic brain injury.
NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury.
Regulatory Role of NADPH Oxidase 2 in the Polarization Dynamics and Neurotoxicity of Microglia/Macrophages after Traumatic Brain Injury.
Brain Ischemia
NADPH oxidase 2 does not contribute to early reperfusion-associated reactive oxygen species generation following transient focal cerebral ischemia.
NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke.
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke.
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Brain Neoplasms
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Breast Neoplasms
Aquaporin-3 Controls Breast Cancer Cell Migration by Regulating Hydrogen Peroxide Transport and Its Downstream Cell Signaling.
DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
Inhibition of breast cancer invasion by TIS21(/BTG2/Pc3)-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes.
Inhibition of NADPH oxidase 4 attenuates lymphangiogenesis and tumor metastasis in breast cancer.
Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells.
Candidiasis
Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth.
Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae.
Carcinogenesis
Allelic variation in gene expression in thyroid tissue.
DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon.
DuOx2 Promoter Regulation by Hormones, Transcriptional Factors and the Coactivator TAZ.
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma.
Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
High Immunoreactivity of DUOX2 Is Associated With Poor Response to Preoperative Chemoradiation Therapy and Worse Prognosis in Rectal Cancers.
Melatonin Attenuates Upregulation of Duox1 and Duox2 and Protects against Lung Injury following Chest Irradiation in Rats.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
NF-?B-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells.
Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract.
NOX1 mediates chemoresistance via HIF1?/MDR1 pathway in gallbladder cancer.
Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer.
Oxidative stress in thyroid carcinomas: biological and clinical significance.
Carcinoma
Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon.
DUOX2 promotes the elimination of the Klebsiella pneumoniae strain K5 from T24 cells through the reactive oxygen species pathway.
Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.
Induction of colonic epithelial cell apoptosis by p47-dependent oxidants.
NADPH oxidases and cancer.
NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines.
NOX5 mediates the crosstalk between tumor cells and cancer-associated fibroblasts via regulating cytokine network.
Redox-regulation of gelatinases during growth of cisplatin-sensitive and resistant Guerin carcinoma.
ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells.
Carcinoma in Situ
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
Carcinoma, Hepatocellular
Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma.
High nuclear NADPH oxidase 4 expression levels are correlated with cancer development and poor prognosis in hepatocellular carcinoma.
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling.
NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy.
NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
PKC? promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells.
Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells.
Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth.
Carcinoma, Squamous Cell
Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.
Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.
Cardiomegaly
Angiotensin II regulates cardiac hypertrophy via oxidative stress but not antioxidant enzyme activities in experimental renovascular hypertension.
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Characterisation of nox4 inhibitors from edible plants.
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan.
Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation.
Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1.
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.
Inhibition of NF-?B activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Inhibition of TNF-? in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.
Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy.
Nobiletin, a Polymethoxy Flavonoid, Protects Against Cardiac Hypertrophy Induced by Pressure-Overload via Inhibition of NAPDH Oxidases and Endoplasmic Reticulum Stress.
Novel Therapeutic Effects of Pterosin B on Ang II-Induced Cardiomyocyte Hypertrophy.
Protective effects of aspirin from cardiac hypertrophy and oxidative stress in cardiomyopathic hamsters.
Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.
Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.
Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice.
Cardiomyopathies
Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function.
Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental chagas disease.
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart.
Cardiomyopathy, Dilated
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart.
Cardiotoxicity
Endurance Exercise Attenuates Doxorubicin-induced Cardiotoxicity.
Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity.
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.
NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity.
Sub-lethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low pro-senescent doses of epirubicin: the protective role of dexrazoxane.
Cardiovascular Diseases
Absence of vascular remodelling in a high angiotensin-II state (Bartter's and Gitelman's syndromes): implications for angiotensin II signalling pathways.
Cerebral vascular effects of reactive oxygen species: recent evidence for a role of NADPH-oxidase.
Circulating progenitor cells are increased in newly diagnosed untreated hypertensive patients with arterial stiffening but normal carotid intima-media thickness.
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.
Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease.
Effect of the NAD(P)H oxidase inhibitor, apocynin, on peripheral nerve perfusion and function in diabetic rats.
Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity.
GPER blockers as Nox downregulators: A new drug class to target chronic non-communicable diseases.
Impact of NAD(P)H oxidase-derived reactive oxygen species on coronary arterial remodeling: a comparative intravascular ultrasound and histochemical analysis of atherosclerotic lesions.
Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization: comparative pharmacokinetics of nitrone-apocynin and its parent apocynin in rats.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
NAD(P)H Oxidase and Endothelial Dysfunction.
NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels.
NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study.
NAD(P)H oxidase p22phox gene C242T polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics.
Novel aspects of oxidative stress in cardiovascular diseases.
Oxidative enzymopathies and vascular disease.
p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis.
Superoxide anion generation and oxidative stress in methylmercury-induced endothelial toxicity in vitro.
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases.
Vascular Biology of Superoxide-Generating NADPH Oxidase 5-Implications in Hypertension and Cardiovascular Disease.
ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing Nox4-Derived ROS Production and Apoptosis.
Carotid Artery Diseases
Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.
Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.
Cerebral Infarction
Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction.
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
[Protective effects of exogenous vitamin D on nerve injury in mice with cerebral ischemia/reperfusion].
[The relationship of P47phox C923T (Ala308Val) polymorphism to cerebral infarction and its effect on plasma lipid levels]
Cerebrovascular Disorders
NOX Inhibitors as a Therapeutic Strategy for Stroke and Neurodegenerative Disease.
The C242T polymorphism of the NAD(P)H oxidase p22phox subunit is associated with an enhanced risk for cerebrovascular disease at a young age.
Chagas Disease
Ovarian dual oxidase (Duox) activity is essential for insect eggshell hardening and waterproofing.
P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.
Chorioamnionitis
NAD(P)H oxidase in human fetal membrane chorion laeve trophoblasts with or without chorioamnionitis: ultrastructural enzyme histochemical study.
Choroidal Neovascularization
The role of vascular endothelial growth factor-induced activation of NADPH oxidase in choroidal endothelial cells and choroidal neovascularization.
Colitis
5-Hydroxytryptamine (5-HT)-exacerbated DSS-induced colitis is associated with elevated NADPH oxidase expression in the colon.
Analysis of candidate colitis genes in the gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.
Colonic blood flow responses in experimental colitis: time course and underlying mechanisms.
Complications of tumor necrosis factor-? blockade in chronic granulomatous disease-related colitis.
Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.
Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2.
Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide.
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans.
Tumor necrosis factor-?-induced colitis increases NADPH oxidase 1 expression, oxidative stress, and neutrophil recruitment in the colon: preventive effect of apocynin.
Colitis, Ulcerative
DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid.
DUOX2 and DUOXA2 Form the Predominant Enzyme System Capable of Producing the Reactive Oxygen Species H2O2 in Active Ulcerative Colitis and are Modulated by 5-Aminosalicylic Acid: ERRATUM.
Colitis-Associated Neoplasms
Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer.
Colonic Neoplasms
5-Hydroxytryptamine (5-HT)-exacerbated DSS-induced colitis is associated with elevated NADPH oxidase expression in the colon.
Attenuating glucose metabolism by Fbxw7 promotes Taxol sensitivity of colon cancer cells through downregulating NADPH oxidase 1 (Nox1).
Clinical Significance of NADPH Oxidase 5 in Human Colon Cancer.
Defective IL-23/IL-17 Axis Protects p47phox-/- Mice from Colon Cancer.
Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts.
Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line.
Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease.
Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells.
Involvement of NADPH oxidases in suppression of cyclooxygenase-2 promoter-dependent transcriptional activities by sesamol.
NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells.
NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction.
NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells.
Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway.
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon.
Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3.
Colorectal Neoplasms
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon.
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
No association between genetic polymorphisms in NAD(P)H oxidase p22phox and paraoxonase 1 and colorectal cancer risk.
Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer.
Congenital Abnormalities
The surgical implications of chronic granulomatous disease.
Congenital Hypothyroidism
A Novel c.554+5C>T Mutation in the DUOXA2 Gene Combined with p.R885Q Mutation in the DUOX2 Gene Causing Congenital Hypothyroidism.
A novel dual oxidase maturation factor 2 gene mutation for congenital hypothyroidism.
A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter.
A Novel mutation in the Thyroglobulin Gene resulting in Neonatal Goiter and Congenital Hypothyroidism in an Eritrean infant.
A Single Copy of the Recently Identified Dual Oxidase Maturation Factor (DUOXA) 1 Gene Produces Only Mild Transient Hypothyroidism in a Patient with a Novel Biallelic DUOXA2 Mutation and Monoallelic DUOXA1 Deletion.
A truncating DUOX2 mutation (R434X) causes severe congenital hypothyroidism.
Aberrant Cerebellar Development in Mice Lacking Dual Oxidase Maturation Factors.
An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs.
Analysis of Worldwide Carrier Frequency and Predicted Genetic Prevalence of Autosomal Recessive Congenital Hypothyroidism Based on a General Population Database.
Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.
Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital hypothyroidism.
Compound heterozygous DUOX2 gene mutations (c.2335-1G>C/c.3264_3267delCAGC) associated with congenital hypothyroidism. Characterization of complex cryptic splice sites by minigene analysis.
Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.
Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.
Congenital hypothyroidism caused by a novel mutation of the dual oxidase 2 (DUOX2) gene.
Congenital hypothyroidism caused by new mutations in the thyroid oxidase 2 (THOX2) gene.
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2.
Delayed onset congenital hypothyroidism in a patient with DUOX2 mutations and maternal iodine excess.
Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.
Disorders of H2O2 generation.
Dual Oxidase System Genes Defects in Children With Congenital Hypothyroidism.
DUOX Defects and Their Roles in Congenital Hypothyroidism.
DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.
DUOX2 Mutations Are Associated With Congenital Hypothyroidism With Ectopic Thyroid Gland.
DUOX2 Mutations Are Frequently Associated With Congenital Hypothyroidism in the Korean Population.
Functional Characterization of DUOX Enzymes in Reconstituted Cell Models.
Genetic and functional analysis of two missense DUOX2 mutations in congenital hypothyroidism and goiter.
Genetic disorders coupled to ROS deficiency.
Genetic Evaluation of Congenital Hypothyroidism with Gland in situ Using Targeted Exome Sequencing.
Genetic Manipulation on Zebrafish duox Recapitulate the Clinical Manifestations of Congenital Hypothyroidism.
Genotype and phenotype correlation in a cohort of Chinese congenital hypothyroidism patients with DUOX2 mutations.
Genotypes and phenotypes of congenital goitre and hypothyroidism caused by mutations in dual oxidase 2 genes.
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Heterozygous Mutations of the DUOXA2 and DUOX2 Genes in Dizygotic Twins with Congenital Hypothyroidism.
High frequency of DUOX2 mutations in transient or permanent congenital hypothyroidism with eutopic thyroid glands.
High prevalence of DUOX2 gene mutations among children with congenital hypothyroidism in central China.
High prevalence of DUOX2 mutations in Japanese patients with permanent congenital hypothyroidism or transient hypothyroidism.
Homozygous DUOXA2 mutation (p.Tyr138(*)) in a girl with congenital hypothyroidism and her apparently unaffected brother: Case report and review of the literature.
Hypothyroidism caused by the combination of two heterozygous mutations: one in the TSH receptor gene the other in the DUOX2 gene.
Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2.
Identification and analyzes of DUOX2 mutations in two familial congenital hypothyroidism cases.
Identification and Functional Analysis of Novel Dual Oxidase 2 (DUOX2) Mutations in Children with Congenital or Subclinical Hypothyroidism.
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
Identification of Two Missense Mutations in DUOX1 (p.R1307Q) and DUOXA1 (p.R56W) That Can Cause Congenital Hypothyroidism Through Impairing H2O2 Generation.
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor.
Insilico study of genes involved in Congenital Hypothyroidism.
Mammalian NADPH Oxidases.
Mice deficient in dual oxidase maturation factors are severely hypothyroid.
Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.
Mutation screening of DUOX2 in Chinese patients with congenital hypothyroidism.
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty.
New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations.
Newborn screening and single nucleotide variation profiling of TSHR, TPO, TG and DUOX2 candidate genes for congenital hypothyroidism.
Next-generation sequencing analysis of DUOX2 in 192 Chinese subclinical congenital hypothyroidism (SCH) and CH patients.
Next-generation sequencing analysis of twelve known causative genes in congenital hypothyroidism.
Novel genetic variants in the TPO gene cause congenital hypothyroidism.
Oxidants in Physiological Processes.
Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings.
Pseudodominant inheritance in a family with nonautoimmune hypothyroidism due to biallelic DUOX2 mutations.
THE CLINICAL AND MOLECULAR CHARACTERIZATION OF PATIENTS WITH DYSHORMONOGENIC CONGENITAL HYPOTHYROIDISM REVEALS SPECIFIC DIAGNOSTIC CLUES FOR DUOX2 DEFECTS.
The Prevalence, Clinical, and Molecular Characteristics of Congenital Hypothyroidism Caused by DUOX2 Mutations: A Population-Based Cohort Study in Guangzhou.
Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program.
Transient congenital hypothyroidism caused by compound heterozygous mutations affecting the NADPH-oxidase domain of DUOX2.
Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism.
Zebrafish duox mutations provide a model for human congenital hypothyroidism.
[DUOX2 mutations in children with congenital hypothyroidism].
[Genetic analysis of TPO, DUOX2 and DUOXA2 genes in children with permanent congenital hypothyroidism suspected dyshormonogenesis].
[Transient congenital hypothyroidism due to biallelic defects of DUOX2 gene. Two clinical cases].
Corneal Injuries
Nox4 Facilitates TGF?1-Induced Fibrotic Response in Human Tenon's Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery.
Corneal Neovascularization
NADPH oxidase 2 plays a role in experimental corneal neovascularization.
Coronary Artery Disease
Coronary artery superoxide production and nox isoform expression in human coronary artery disease.
Dose-dependent regulation of NAD(P)H oxidase expression by angiotensin II in human endothelial cells: protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease.
Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation.
Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis.
Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease.
Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy.
Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth.
Superoxide production and expression of nox family proteins in human atherosclerosis.
Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins.
The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia.
Coronary Disease
Oxidant stress-a major cause of reduced endothelial nitric oxide availability in cardiovascular disease.
The A640G polymorphism in the NAD(P)H oxidase p22phox gene (CYBA) is associated with risk reduction of coronary heart disease: A meta-analysis.
Crohn Disease
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
Expression of the genes dual oxidase 2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn's disease.
Cysts
Plant parasitic cyst nematodes redirect host indole metabolism via NADPH oxidase-mediated ROS to promote infection.
Deafness
Exome sequencing identifies SLC26A4, GJB2, SCARB2 and DUOX2 mutations in 2 siblings with Pendred syndrome in a Malaysian family.
Dehydration
Mononuclear thorium halide clusters ThX4 (X = F, Cl): gas-phase hydrolysis reactions.
Water stress-induced abscisic acid accumulation triggers the increased generation of reactive oxygen species and up-regulates the activities of antioxidant enzymes in maize leaves.
Dementia
Novel isoforms of NADPH-oxidase in cerebral vascular control.
Dementia, Vascular
NADPH Oxidase 1, a Novel Molecular Source of ROS in Hippocampal Neuronal Death in Vascular Dementia.
Demyelinating Diseases
Oxidative Injury and Iron Redistribution Are Pathological Hallmarks of Marmoset Experimental Autoimmune Encephalomyelitis.
Dermatitis, Atopic
[Expression of DUOX2 in psoriasis and atopic dermatitis lesion].
Diabetes Complications
Effect of the NAD(P)H oxidase inhibitor, apocynin, on peripheral nerve perfusion and function in diabetic rats.
NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications.
Diabetes Mellitus
Adiponectin As A Link Between Type 2 Diabetes Mellitus And Vascular NADPH-Oxidase Activity In The Human Arterial Wall: The Regulatory Role Of Perivascular Adipose Tissue.
APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice.
Association of the C242T polymorphism in the NAD(P)H oxidase P22 phox gene with type 2 diabetes mellitus risk: a meta-analysis.
Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.
Effect of the NAD(P)H oxidase inhibitor, apocynin, on peripheral nerve perfusion and function in diabetic rats.
Inhibition of NAD(P)H Oxidase Alleviates Impaired NOS-dependent Responses of Pial Arterioles in Type 1 Diabetes Mellitus.
Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase.
Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors.
NAD(P)H oxidase participates in the signaling events in high glucose-induced proliferation of vascular smooth muscle cells.
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.
Diabetes Mellitus, Type 1
Association of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes.
Inhibition of NAD(P)H Oxidase Alleviates Impaired NOS-dependent Responses of Pial Arterioles in Type 1 Diabetes Mellitus.
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney.
Protein kinase C-dependent NAD(P)H oxidase activation induced by type 1 diabetes in renal medullary thick ascending limb.
Diabetes Mellitus, Type 2
A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.
Adiponectin As A Link Between Type 2 Diabetes Mellitus And Vascular NADPH-Oxidase Activity In The Human Arterial Wall: The Regulatory Role Of Perivascular Adipose Tissue.
Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.
Association of the C242T polymorphism in the NAD(P)H oxidase P22 phox gene with type 2 diabetes mellitus risk: a meta-analysis.
Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.
Effect of PAR2 in regulating TNF-? and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice.
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist.
Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes.
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice.
Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.
Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.
Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM.
Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice.
Upregulation of TNF-alpha and Receptors Contribute to Endothelial Dysfunction in Zucker Diabetic Rats.
Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
Diabetic Angiopathies
GLP-1 Inhibits High-Glucose-Induced Oxidative Injury of Vascular Endothelial Cells.
NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.
Diabetic Cardiomyopathies
Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models.
Diabetic Nephropathies
Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.
APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice.
Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.
Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis.
Association of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes.
Attenuating effect of angiotensin-(1-7) on angiotensin II-mediated NAD(P)H oxidase activation in type 2 diabetic nephropathy of KK-Ay/Ta mice.
Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase.
Characterisation of nox4 inhibitors from edible plants.
Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease.
Effects of NADPH oxidase inhibitor in diabetic nephropathy.
GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.
Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox.
HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose.
Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease.
Metformin induces suppression of NAD(P)H oxidase activity in podocytes.
Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice.
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy.
NADPH oxidase 5 and renal disease.
Naringin ameliorates diabetic nephropathy by inhibiting NADPH oxidase 4.
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB.
Oxidative stress as a major culprit in kidney disease in diabetes.
Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling.
Suppressing renal NADPH oxidase to treat diabetic nephropathy.
The association of NAD(P)H oxidase p22phox with diabetic nephropathy is still uncertain: response to Hodgkinson, Millward, and Demaine.
Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy.
Diabetic Neuropathies
Effect of the NAD(P)H oxidase inhibitor, apocynin, on peripheral nerve perfusion and function in diabetic rats.
Diabetic Retinopathy
A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.
Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy.
Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy.
The Regulatory Role of Rac1, a Small Molecular Weight GTPase, in the Development of Diabetic Retinopathy.
Dwarfism
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2.
Ehrlichiosis
Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox.
Encephalomyelitis
Ongoing Oxidative Stress Causes Subclinical Neuronal Dysfunction in the Recovery Phase of EAE.
Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation.
Encephalomyelitis, Autoimmune, Experimental
Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide.
Ongoing Oxidative Stress Causes Subclinical Neuronal Dysfunction in the Recovery Phase of EAE.
Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation.
Endometrial Neoplasms
NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer.
Endotoxemia
Female X-chromosome mosaicism for gp91phox expression diversifies leukocyte responses during endotoxemia.
Propofol inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression through decreasing the generation of superoxide anion in cardiomyocytes.
Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia.
Enterocolitis, Necrotizing
Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis.
Eosinophilia
Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).
Epilepsy
Activation of the phagocyte NADPH oxidase/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine.
Fish oil provides protection against the oxidative stress in pilocarpine model of epilepsy.
Imbalance of Systemic Redox Biomarkers in Children with Epilepsy: Role of Ferroptosis.
Erectile Dysfunction
Hypercholesterolemia-Induced Erectile Dysfunction: Endothelial Nitric Oxide Synthase (eNOS) Uncoupling in the Mouse Penis by NAD(P)H Oxidase.
Upregulation of gp91phox subunit of NAD(P)H oxidase contributes to erectile dysfunction caused by long-term nitric oxide inhibition in rats: reversion by regular physical training.
Esophageal Squamous Cell Carcinoma
NOX5 mediates the crosstalk between tumor cells and cancer-associated fibroblasts via regulating cytokine network.
Esophagitis
Viewpoints on Acid-induced inflammatory mediators in esophageal mucosa.
Essential Hypertension
Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period.
The human ATF1 rs11169571 polymorphism increases essential hypertension risk through modifying miRNA binding.
Fatty Liver
Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats.
The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis.
Fragile X Syndrome
Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice, a pathological model for Fragile X syndrome.
Gastritis
Uncovering the Mechanisms and Molecular Targets of Weibing Formula 1 against Gastritis: Coupling Network Pharmacology with GEO Database.
Gastrointestinal Neoplasms
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
Genetic Diseases, Inborn
Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice.
CD34+ peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease.
Complications of tumor necrosis factor-? blockade in chronic granulomatous disease-related colitis.
Influence of Neutrophil Defects on Burkholderia cepacia Complex Pathogenesis.
Peptide-based inhibitors of the phagocyte NADPH oxidase.
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism.
[The Nox/Duox family of ROS-generating NADPH oxidases]
Giant Cell Arteritis
NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.
Glioblastoma
Inhibition of NADPH Oxidase-4 Potentiates 2-Deoxy-D-Glucose-Induced Suppression of Glycolysis, Migration, and Invasion in Glioblastoma Cells: Role of the Akt/HIF1?/HK-2 Signaling Axis.
Glomerulonephritis, IGA
No association between a genetic variant of the p22(phox) component of NAD(P)H oxidase and the incidence and progression of IgA nephropathy.
Glucose Intolerance
Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress.
EFFECT OF CHRONIC ASPIRIN ADMINISTRATION ON AN EXPERIMENTAL MODEL OF METABOLIC SYNDROME.
Inhibition of hypothalamic inhibitor ? B kinase ?/nuclear transcription factor ? B pathway attenuates metabolism and cardiac dysfunction in type 2 diabetic rats.
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine.
Glucosephosphate Dehydrogenase Deficiency
Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine.
glutathione peroxidase deficiency
Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension.
Goiter
A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter.
Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.
Correction to: Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism by Dufort G, Larrivée-Vanier S, Eugène D, De Deken X, Seebauer B, Heinimann K, Lévesque S, Gravel S, Szinnai G, Van Vliet G, and Deladoëy J. Thyroid 2019;29:1018-1022.
Defects in protein folding in congenital hypothyroidism.
Exome sequencing identifies SLC26A4, GJB2, SCARB2 and DUOX2 mutations in 2 siblings with Pendred syndrome in a Malaysian family.
Genetic and functional analysis of two missense DUOX2 mutations in congenital hypothyroidism and goiter.
Identification and Functional Analysis of Novel Dual Oxidase 2 (DUOX2) Mutations in Children with Congenital or Subclinical Hypothyroidism.
THE CLINICAL AND MOLECULAR CHARACTERIZATION OF PATIENTS WITH DYSHORMONOGENIC CONGENITAL HYPOTHYROIDISM REVEALS SPECIFIC DIAGNOSTIC CLUES FOR DUOX2 DEFECTS.
Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A>C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect.
Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism.
[DUOX2 gene mutation in patients with congenital goiter with hypothyroidism].
[Influence of genetic factors on the result of therapy for diffuse euthyroid goiter].
[The thyroid as a model for molecular mechanisms in genetic diseases]
Gout
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.
Granuloma
Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease.
Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab.
Concomitant Gene Mutations of MBL and CYBB in Chronic Granulomatous Disease: Implications for Host Defense.
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Granulomatous Disease, Chronic
A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl.
A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease.
A mutation located at the 5' splice junction sequence of intron 3 in the p67phox gene causes the lack of p67phox mRNA in a patient with chronic granulomatous disease.
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
A Novel Bacterium Associated with Lymphadenitis in a Patient with Chronic Granulomatous Disease.
A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phox.
A novel element in the management of chronic granulomatous disease (CGD)? - treatment of osteomyelitis with additional hyperbaric oxygen therapy (HBO).
A Novel Mutation in Chronic Granulomatous Disease: Treating the Family, Not Just the Patient.
A novel mutation in CYBB induced X-linked chronic granulomatous disease: A case report.
A Shifted Composition of the Lung Microbiota Conditions the Antifungal Response of Immunodeficient Mice.
A variant X-linked chronic granulomatous disease patient (X91+) with partially functional cytochrome b.
Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus.
Accelerated calcium influx and hyperactivation of neutrophils in chronic granulomatous disease.
Actinomyces in Chronic Granulomatous Disease: An Emerging and Unanticipated Pathogen.
Actinomycosis and nocardiosis co-infection in chronic granulomatous disease.
Activation of cryptic splice sites in three patients with chronic granulomatous disease.
Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox.
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
Activation of the small GTPase rap1 in human neutrophils.
Adenovirus-mediated gene transfer into monocyte-derived macrophages of patients with X-linked chronic granulomatous disease: ex vivo correction of deficient respiratory burst.
Advances in the diagnosis and treatment of chronic granulomatous disease.
Altered expression of neutrophil peripheral benzodiazepine receptor in X-linked chronic granulomatous disease.
Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells.
Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).
An in-frame triplet deletion within the gp91-phox gene in an adult X-linked chronic granulomatous disease patient with residual NADPH-oxidase activity.
Assessment of atherosclerosis in chronic granulomatous disease.
Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in the NCF-1 pseudogenes.
Autosomal recessive chronic granulomatous disease caused by novel mutations in NCF-2, the gene encoding the p67-phox component of phagocyte NADPH oxidase.
Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation.
Baculovirus mediated expression of human phagocytic cell oxidase cytochrome b558 in sf9 insect cells.
Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice.
Bronchocentric granulomatosis as a first clinical manifestation in an adult patient with p67phox deficiency.
CD34+ peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease.
Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene).
Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease.
Characterization of the p67phox gene: genomic organization and restriction fragment length polymorphism analysis for prenatal diagnosis in chronic granulomatous disease.
Chronic granulomatous disease caused by mutations other than the common GT deletion in NCF1, the gene encoding the p47phox component of the phagocyte NADPH oxidase.
Chronic granulomatous disease in Israel: clinical, functional and molecular studies of 38 patients.
Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab.
Chronic granulomatous disease.
Chronic granulomatous disease. Molecular genetics.
Chronic granulomatous disease: lessons from a rare disorder.
Clinical Features and Genetic Analysis of 48 Patients with Chronic Granulomatous Disease in a Single Center Study from Shanghai, China (2005-2015): New Studies and a Literature Review.
Cloning of murine gp91phox cDNA and functional expression in a human X-linked chronic granulomatous disease cell line.
Complications of tumor necrosis factor-? blockade in chronic granulomatous disease-related colitis.
Concomitant Gene Mutations of MBL and CYBB in Chronic Granulomatous Disease: Implications for Host Defense.
CYBB mutation analysis in X-linked chronic granulomatous disease.
Cytochrome b-245 of the neutrophil superoxide-generating system contains two nonidentical hemes. Potentiometric studies of a mutant form of gp91phox.
Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain.
Decreased STAT5 phosphorylation and GATA-3 expression in NOX2 deficient T cells: Role in T helper development.
Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility.
Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhood.
Diabetes, Renal and Cardiovascular Disease in p47( phox-/-) Chronic Granulomatous Disease.
Different degrees of NADPH oxidase 2 regulation and in vivo platelet activation: lesson from chronic granulomatous disease.
Differential Transgene Silencing of Myeloid-Specific Promoters in the AAVS1 Safe Harbor Locus of Induced Pluripotent Stem Cell-Derived Myeloid Cells.
Disseminated Bacillus Calmette-Guérin lymphadenitis in a patient with gp91phox (-) chronic granulomatous disease 25 years after vaccination.
Disseminated Tuberculosis in a Patient with Autosomal Recessive p47phox Chronic Granulomatous Disease.
Drug-selected complete restoration of superoxide generation in Epstein-Barr virus-transformed B cells from p47phox-deficient chronic granulomatous disease patients by using a bicistronic retrovirus vector encoding a human multi-drug resistance gene (MDR1) and the p47phox gene.
Elevated Mitochondrial Reactive Oxygen Species and Cellular Redox Imbalance in Human NADPH-Oxidase-Deficient Phagocytes.
Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease.
Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease.
Enhanced generation of reactive oxygen species by interferon-? may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease.
Enhanced Th2 cell differentiation and function in the absence of Nox2.
Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutations.
Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer.
Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox.
Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase.
Genetic correction of p67phox deficient chronic granulomatous disease using peripheral blood progenitor cells as a target for retrovirus mediated gene transfer.
Genetic Diagnostic Elucidation of a Patient With Multiorgan Granulomas, Facial Peculiarities, and Psychomotor Retardation.
Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs.
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease.
Granulibacter bethesdensis, a Pathogen from Patients with Chronic Granulomatous Disease, Produces a Penta-Acylated Hypostimulatory Glycero-D-talo-oct-2-ulosonic Acid-Lipid A Glycolipid (Ko-Lipid A).
Health-Related Quality of Life and Emotional Health in X-Linked Carriers of Chronic Granulomatous Disease in the United Kingdom.
Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.
High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-Free CRISPR/Cas9 Genome Editing.
High-level reconstitution of respiratory burst activity in a human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox.
Histaminergic regulation of interferon-gamma (IFN-gamma) production by human natural killer (NK) cells.
How the phagocyte NADPH oxidase regulates innate immunity.
HSCT in two brothers with CGD arising from mutations in CYBC1 corrects the defect in neutrophil function.
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase.
Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells.
Identification of a double mutation (D160V-K161E) in the p67phox gene of a chronic granulomatous disease patient.
Identification of allele-specific p22-phox mutations in a compound heterozygous patient with chronic granulomatous disease by mismatch PCR and restriction enzyme analysis.
Identification of Cytochrome b-245, beta-chain gene mutations, and clinical presentations in Iranian patients with X-linked chronic granulomatous disease.
Identification of mutations in seven Chinese patients with X-linked chronic granulomatous disease.
Identification of the defective NADPH-oxidase component in chronic granulomatous disease: a study of 57 European families.
Impaired respiratory burst contributes to infections in PKC?-deficient patients.
Improved superoxide-generating ability by interferon gamma due to splicing pattern change of transcripts in neutrophils from patients with a splice site mutation in CYBB gene.
In vitro interferon ? improves the oxidative burst activity of neutrophils in patients with chronic granulomatous disease with a subtype of gp91phox deficiency.
In vivo role of myeloperoxidase for the host defense.
Inheritance Pattern and Clinical Aspects of 93 Iranian Patients with Chronic Granulomatous Disease.
Interferon gamma-1b. A review of its pharmacology and therapeutic potential in chronic granulomatous disease.
Intersecting Stories of the Phagocyte NADPH Oxidase and Chronic Granulomatous Disease.
Interstitial lung disease in a patient with chronic granulomatous disease.
Invasive aspergillosis in primary immunodeficiencies.
Investigation of the interleukin (IL)-4/IL-4 receptor system in promyelocytic leukaemia PLB-985 cells during differentiation toward neutrophil-like phenotype: mechanism involved in IL-4-induced SOCS3 protein expression.
Involvement of p40phox in activation of phagocyte NADPH oxidase through association of its carboxyl-terminal, but not its amino-terminal, with p67phox.
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.
Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.
Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b558, to the extracellular peptide portion of primate gp91phox.
Long-term correction of phagocyte NADPH oxidase activity by retroviral-mediated gene transfer in murine X-linked chronic granulomatous disease.
Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker.
Mechanisms for the activation/electron transfer of neutrophil NADPH-oxidase complex and molecular pathology of chronic granulomatous disease.
Mechanisms of NADPH oxidase activation in human neutrophils: p67phox is required for the translocation of rac 1 but not of rac 2 from cytosol to the membranes.
Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox.
Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation.
Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail.
Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations.
Molecular genetics of chronic granulomatous disease.
Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox.
NAD(P)H Oxidase and Endothelial Dysfunction.
NCF1 (p47phox)-deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis.
Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish.
NOX Inhibitors: From Bench to Naxibs to Bedside.
NOX5 and p22phox are two novel regulators of human monocytic differentiation into dendritic cells.
O2- production by B lymphocytes lacking the respiratory burst oxidase subunit p47phox after transfection with an expression vector containing a p47phox cDNA.
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Oxidants in Physiological Processes.
Oxidative killing of microbes by neutrophils.
p47(phox) Directs Murine Macrophage Cell Fate Decisions.
Partial reconstitution of the respiratory burst oxidase in lymphoblastoid B cell lines lacking p67-phox after transfection with an expression vector containing wild-type and mutant p67 -phox cDNAs: Deletions of the carboxy and amino terminal residues of p67-phox are not required for activity.
Peptide-based inhibitors of the phagocyte NADPH oxidase.
Persistence of the Bacterial Pathogen Granulibacter bethesdensis in Chronic Granulomatous Disease Monocytes and Macrophages Lacking a Functional NADPH Oxidase.
Phagocyte NADPH oxidase and specific immunity.
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections.
Phellinus tropicalis abscesses in a patient with chronic granulomatous disease.
Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells.
PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes.
Pulmonary manifestations of chronic granulomatous disease.
Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease.
Reconstitution of NADPH oxidase activity in human X-linked chronic granulomatous disease myeloid cells after stable gene transfer using a recombinant adeno-associated virus 2 vector.
Retrotransposable genetic elements causing neutrophil defects.
Retroviral expression of recombinant p47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous disease.
Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation.
Retroviral-mediated gene transfer of gp91phox into bone marrow cells rescues defect in host defense against Aspergillus fumigatus in murine X-linked chronic granulomatous disease.
Retrovirus-mediated reconstitution of respiratory burst activity in X-linked chronic granulomatous disease cells.
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.
Sea blue histiocytes in the bone marrow of variant chronic granulomatous disease with residual monocyte NADPH-oxidase activity.
Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation.
Signed outside: a surface marker system for transgenic cytoplasmic proteins.
Six different CYBA mutations including three novel mutations in ten families from Turkey, resulting in autosomal recessive chronic granulomatous disease.
Stabilization of human neutrophil NADPH oxidase activated in a cell-free system by cytosolic proteins and by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
Staphylococcus aureus, phagocyte NADPH oxidase and chronic granulomatous disease.
Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency.
Structure-function effects in primary immunodeficiencies.
Subcellular localization and dynamics of components of the respiratory burst oxidase.
Sulfite stimulates NADPH oxidase of human neutrophils to produce active oxygen radicals via protein kinase C and Ca2+/calmodulin pathways.
Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease.
Thapsigargin and flavin adenine dinucleotide ex vivo treatment rescues trafficking-defective gp91phox in chronic granulomatous disease leukocytes.
The active N-terminal region of p67phox. Structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease.
The p47phox mouse knock-out model of chronic granulomatous disease.
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
The role of reactive oxygen intermediates in experimental coccidioidomycois in mice.
The search for a genetic defect in Polish patients with chronic granulomatous disease.
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism.
The surgical implications of chronic granulomatous disease.
Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease.
Transient association of the nicotinamide adenine dinucleotide phosphate oxidase subunits p47phox and p67phox with phagosomes in neutrophils from patients with X-linked chronic granulomatous disease.
Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC.
Undiagnosed Chronic Granulomatous Disease, Burkholderia cepacia complex Pneumonia, and Acquired Hemophagocytic Lymphohistiocytosis: A Deadly Association.
Unusual late presentation of X-linked chronic granulomatous disease in an adult female with a somatic mosaic for a novel mutation in CYBB.
X-linked chronic granulomatous disease in a male child with an X-CGD carrier, Klinefelter brother.
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase.
[A report of a family with chronic granulomatous disease with a gp91phox disorder]
[Amyloidosis associated with chronic granulomatous disease in a patient with a renal transplant and recurrent urinary tract infections]
[Chronic granulomatous disease (CGD): dysfunction of the neutrophil granulocyte NADPH-oxidase enzyme system]
[Chronic granulomatous disease as a rare differential diagnosis of inflammatory bowel disease].
[Chronic granulomatous disease: multiple infections as clinical presentation. Pediatric case report].
[Role of myeloperoxidase in the host defense against fungal infection]
[Statistical evaluation of chronic granulomatous disease in Japan and basic studies for gene therapy for CGD patients]
[The NADPH-oxidase complex in chronic granulomatous disease: preliminary description of a cluster in Mérida-Venezuela]
[The Nox/Duox family of ROS-generating NADPH oxidases]
Granulosa Cell Tumor
A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells.
Graves Disease
Autoimmune thyroid disease: mechanism, genetics and current knowledge.
Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide.
Hashimoto Disease
Autoimmune thyroid disease: mechanism, genetics and current knowledge.
Hearing Loss
Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2.
Heart Diseases
Calcium dysregulation in ventricular myocytes from mice expressing constitutively active Rac1.
Investigation of the C242T polymorphism of NAD(P)H oxidase p22 phox gene and ischaemic heart disease using family-based association methods.
Heart Failure
Antioxidative effect of p38 mitogen-activated protein kinase inhibitor in the kidney of hypertensive rat.
Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release.
Cardioprotective effect of benidipine on cardiac performance and remodeling in failing rat hearts.
Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor.
Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments.
NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.
NADPH Oxidase 4 Regulates Inflammation in Ischemic Heart Failure: Role of Soluble Epoxide Hydrolase.
Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in post-infarct heart failure.
Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase.
Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase.
TNF-alpha blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats.
Hepatitis
Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair.
Hepatitis B
Soluble E-cadherin is associated with oxidative stress in patients with chronic HBV infection.
Hepatitis C
Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C.
Hepatitis C Viral Proteins induce NADPH Oxidase 4 (Nox4) in a TGF{beta}-dependent manner: A new contributor of HCV-induced oxidative stress.
Hepatitis C, Chronic
Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C.
Hepatoblastoma
Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells.
Hernia, Umbilical
Identification and analyzes of DUOX2 mutations in two familial congenital hypothyroidism cases.
Herpes Simplex
A Monocyte-Specific Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Activates the NADPH-Oxidase but Not Chemotaxis through a G-Protein-Coupled Receptor Distinct from the Members of the Formyl Peptide Receptor Family.
Herpes Zoster
Heme modulates intestinal epithelial cell activation: involvement of NADPHox-derived ROS signaling.
Huntington Disease
NAD(P)H oxidase contributes to neurotoxicity in an excitotoxic/prooxidant model of Huntington's disease in rats: Protective role of apocynin.
Hyperaldosteronism
OXIDATIVE STRESS RELATED PROTEINS IN A CONN'S ADENOMA TISSUE. RELEVANCE FOR ALDOSTERONE'S PROOXIDATIVE AND PROINFLAMMATORY ACTIVITY.
Hyperalgesia
Advanced oxidation protein products sensitized the transient receptor potential vanilloid 1 via NADPH oxidase 1 and 4 to cause mechanical hyperalgesia.
Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain.
Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
Hypercholesterolemia
Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia.
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism.
Hypercholesterolemia-Induced Erectile Dysfunction: Endothelial Nitric Oxide Synthase (eNOS) Uncoupling in the Mouse Penis by NAD(P)H Oxidase.
Importance of NAD(P)H oxidase-mediated oxidative stress and contractile type smooth muscle myosin heavy chain SM2 at the early stage of atherosclerosis.
LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes.
NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction.
Phagocyte NADPH oxidase, oxidative stress and lipids: Anti- or pro ageing?
Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia.
Hyperemia
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
Hyperglycemia
Activation of endothelial NAD(P)H oxidase accelerates early glomerular injury in diabetic mice.
Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury.
Enhanced vascular production of superoxide in OLETF rat after the onset of hyperglycemia.
Gp91phox (NOX2) in Activated Microglia Exacerbates Neuronal Damage Induced by Oxygen Glucose Deprivation and Hyperglycemia in an in Vitro Model.
Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes.
Hyperglycemia enhances IGF-I-stimulated Src activation via increasing Nox4-derived reactive oxygen species in a PKC?-dependent manner in vascular smooth muscle cells.
Hyperglycemia stimulates p62/PKC? interaction, which mediates NF-?B activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle.
Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice.
Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway.
Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia.
Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase.
Role of brainstem thyrotropin-releasing hormone-triggered sympathetic overactivation in cardiovascular mortality in type 2 diabetic Goto-Kakizaki rats.
Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
[Oxidative stress and endothelial dysfunction.]
Hyperhomocysteinemia
Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementation.
Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase.
Hyperinsulinism
Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress.
Inhibition of hypothalamic inhibitor ? B kinase ?/nuclear transcription factor ? B pathway attenuates metabolism and cardiac dysfunction in type 2 diabetic rats.
Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation.
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Hypersensitivity
Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis.
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.
NADPH oxidase activity in allergenic pollen grains of different plant species.
Neuronal NOS activates spinal NADPH oxidase 2 contributing to central sigma-1 receptor-induced pain hypersensitivity in mice.
Role of pollen NAD(P)H oxidase in allergic inflammation.
Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
Toll-like Receptor 2 Mediates Peripheral Nerve Injury-induced NADPH Oxidase 2 Expression in Spinal Cord Microglia.
Hypertension
Age-related hypertension and salt sensitivity are associated with unique cortico-medullary distribution of D1R, AT1R, and NADPH-oxidase in FBN rats.
Angiotensin II induces superoxide generation via NAD(P)H oxidase activation in isolated rat pancreatic islets.
Angiotensin II type 1 receptor antagonist and angiotensin-converting enzyme inhibitor altered the activation of Cu/Zn-containing superoxide dismutase in the heart of stroke-prone spontaneously hypertensive rats.
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Angiotensin II-induced over-activation of p47phox in fibroblasts from hypertensives: which role in the enhanced ERK1/2 responsiveness to angiotensin II?
Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat.
Apocynin but Not l-Arginine Prevents and Reverses Dexamethasone-Induced Hypertension in the Rat.
Apocynin improves endothelial function and prevents the development of hypertension in fructose fed rat.
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.
AT2 receptors cross talk with AT1 receptors through a nitric oxide- and RhoA-dependent mechanism resulting in decreased phospholipase D activity.
c-Src, ERK1/2 and Rho kinase mediate hydrogen peroxide-induced vascular contraction in hypertension: role of TXA2, NAD(P)H oxidase and mitochondria.
Cerebral vascular effects of reactive oxygen species: recent evidence for a role of NADPH-oxidase.
Chronic Mercury Exposure in Prehypertensive SHRs Accelerates Hypertension Development and Activates Vasoprotective Mechanisms by Increasing NO and H2O2 Production.
Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease.
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan.
Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats.
Developmental programming of eNOS uncoupling and enhanced vascular oxidative stress in adult rats after transient neonatal oxygen exposure.
Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model.
Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease.
Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats.
Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney.
Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.
Flow- and acetylcholine-induced dilatation in small arteries from rats with renovascular hypertension--effect of tempol treatment.
Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension.
Ghrelin inhibits vascular superoxide production in spontaneously hypertensive rats.
High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase.
Implications of NADPH oxidase 5 in vascular diseases.
Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension.
Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: involvement of the renin-angiotensin system.
Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension.
Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo.
Inhibition of NF-?B activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Inhibition of TNF-? in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.
Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
Intra-renal angiotensin II/AT1 receptor, oxidative stress, inflammation, and progressive injury in renal mass reduction.
Intracellular signalling pathways regulating vascular NAD(P)H oxidase and hypertension: an opportunity for development of novel antihypertensive agents?
Local angiotensin II aggravates cardiac remodeling in hypertension.
Losartan exerts renoprotection through NAD(P)H oxidase downregulation in a renovascular model of hypertension.
Membrane Trafficking of NADPH Oxidase p47phox in Paraventricular Hypothalamic Neurons Parallels Local Free Radical Production in Angiotensin II Slow-Pressor Hypertension.
Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress.
NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats.
NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects.
NAD(P)H-dependent superoxide production in platelets: the role of angiotensin II and protein kinase C.
NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities.
NF-?B Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1.
NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE.
Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice.
Novel isoforms of NADPH-oxidase in cerebral vascular control.
Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney.
Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets.
Oxidative stress in arterial hypertension: role of NAD(P)H oxidase.
Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension.
Oxidative stress-associated vascular aging is independent of the protein kinase C/NAD(P)H oxidase pathway.
Paraventricular Nucleus Infusion of Epigallocatechin-3-O-Gallate Improves Renovascular Hypertension.
Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats.
Pharmacology of apocynin: a natural acetophenone.
Reactive oxygen species derived from NAD(P)H oxidase play a role on ethanol-induced hypertension and endothelial dysfunction in rat resistance arteries.
Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension.
Reduced NAD(P)H oxidase in low renin hypertension: link among angiotensin II, atherogenesis, and blood pressure.
Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.
Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension.
Renal molecular mechanisms underlying altered Na+ handling and genesis of hypertension during adulthood in prenatally undernourished rats.
Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner.
Role of gp91phox-containing NADPH oxidase in the deoxycorticosterone acetate-salt-induced hypertension.
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Role of NAD(P)H oxidase and its regulation in chronic hypertension.
Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice.
Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice.
Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension.
Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations.
Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension.
The NAD(P)H oxidase inhibitor apocynin improves endothelial NO/superoxide balance and lowers effectively blood pressure in spontaneously hypertensive rats: comparison to calcium channel blockade.
The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.
The role of the renin-angiotensin system and oxidative stress in spontaneously hypertensive rat mesenteric collateral growth impairment.
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases.
Up-regulation of Akt and eNOS induces vascular smooth muscle cell differentiation in hypertension in vivo.
Upregulation of vascular NAD(P)H oxidase subunit gp91phox and impairment of the nitric oxide signal transduction pathway in hypertension.
Vascular Biology of Superoxide-Generating NADPH Oxidase 5-Implications in Hypertension and Cardiovascular Disease.
Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation.
Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat.
Hypertension, Portal
NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats.
Hypertension, Pulmonary
Enhanced Depolarization-Induced Pulmonary Vasoconstriction Following Chronic Hypoxia Requires EGFR-dependent Activation of NAD(P)H Oxidase 2.
NADPH oxidase 4 is not involved in hypoxia-induced pulmonary hypertension.
Proline-rich tyrosine kinase 2 downregulates peroxisome proliferator-activated receptor gamma to promote hypoxia-induced pulmonary artery smooth muscle cell proliferation.
Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.
Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration.
The Nox4 Inhibitor, GKT137831, Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation.
Hypertension, Renovascular
Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative stress markers in the kidney in Wistar rats.
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan.
Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla.
Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner.
Hyperthyroidism
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters.
Hypertriglyceridemia
Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis.
NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE.
Hypertrophy, Left Ventricular
Critical role of bradykinin-eNOS and oxidative stress-LOX-1 pathway in cardiovascular remodeling under chronic angiotensin-converting enzyme inhibition.
Hypoalbuminemia
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Hypotension
Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats.
Hypothyroidism
A Single Copy of the Recently Identified Dual Oxidase Maturation Factor (DUOXA) 1 Gene Produces Only Mild Transient Hypothyroidism in a Patient with a Novel Biallelic DUOXA2 Mutation and Monoallelic DUOXA1 Deletion.
Double variants in TSHR and DUOX2 in a patient with hypothyroidism: case report.
Dual oxidase, hydrogen peroxide and thyroid diseases.
DUOX Defects and Their Roles in Congenital Hypothyroidism.
DUOX2 variants are a frequent cause of congenital primary hypothyroidism in Thai patients.
DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom.
Expanding the phenotype of thrombocytopenia absent radius syndrome with hypospadias.
Genetic Evaluation of Congenital Hypothyroidism with Gland in situ Using Targeted Exome Sequencing.
Genetics of Thyroid Disorders.
Genotype and phenotype correlation in a cohort of Chinese congenital hypothyroidism patients with DUOX2 mutations.
Genotype-phenotype correlations of dyshormonogenetic goiter in children and adolescents from South India.
Genotypes and phenotypes of congenital goitre and hypothyroidism caused by mutations in dual oxidase 2 genes.
gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism.
High prevalence of DUOX2 mutations in Japanese patients with permanent congenital hypothyroidism or transient hypothyroidism.
Hypothyroidism caused by the combination of two heterozygous mutations: one in the TSH receptor gene the other in the DUOX2 gene.
Identification and Functional Analysis of Novel Dual Oxidase 2 (DUOX2) Mutations in Children with Congenital or Subclinical Hypothyroidism.
Molecules important for thyroid hormone synthesis and action - known facts and future perspectives.
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty.
New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations.
Persistent mild hypothyroidism associated with novel sequence variants of the DUOX2 gene in two siblings.
Pseudodominant inheritance in a family with nonautoimmune hypothyroidism due to biallelic DUOX2 mutations.
Role of the NADPH Oxidases DUOX and NOX4 in Thyroid Oxidative Stress.
Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain.
Transient congenital hypothyroidism - too short to be transient.
Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program.
Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism.
[DUOX2 gene mutation in patients with congenital goiter with hypothyroidism].
Ileitis
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
Infarction, Middle Cerebral Artery
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke.
Infections
A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
A Novel Bacterium Associated with Lymphadenitis in a Patient with Chronic Granulomatous Disease.
A Novel Mutation in Chronic Granulomatous Disease: Treating the Family, Not Just the Patient.
Actinomyces in Chronic Granulomatous Disease: An Emerging and Unanticipated Pathogen.
Actinomycosis and nocardiosis co-infection in chronic granulomatous disease.
Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).
An absence of reactive oxygen species improves the resolution of lung influenza infection.
ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.
ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17.
Both inducible nitric oxide synthase and NADPH oxidase contribute to the control of virulent phase I Coxiella burnetii infections.
C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.
Candida albicans infection disturbs redox homeostasis system and induces reactive oxygen species accumulation for epithelial cell death.
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans.
Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells.
Cellular Therapies in Chronic Granulomatous Disease.
Chronic Granulomatous Disease.
Clinical Features and Genetic Analysis of 48 Patients with Chronic Granulomatous Disease in a Single Center Study from Shanghai, China (2005-2015): New Studies and a Literature Review.
Complications of tumor necrosis factor-? blockade in chronic granulomatous disease-related colitis.
Counteraction of HCV-Induced Oxidative Stress Concurs to Establish Chronic Infection in Liver Cell Cultures.
Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox.
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.
Deleterious Effects of Neonicotinoid Pesticides on Drosophila melanogaster Immune Pathways.
Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium.
Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD).
Dual oxidase 1 promotes antiviral innate immunity.
Dual oxidase 2 and glutathione peroxidase gene expression are elevated in hyperimmunised sheep challenged with Haemonchus contortus.
Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism.
DUOX2 promotes the elimination of the Klebsiella pneumoniae strain K5 from T24 cells through the reactive oxygen species pathway.
DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.
Duox2-derived Reactive Oxygen Species Induce Pattern Recognition Receptors' Expression Against Influenza A Virus in Nasal Mucosa.
Duox2-induced innate immune responses in the respiratory epithelium and intranasal delivery of Duox2 DNA using polymer that mediates immunization.
Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach.
Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection.
Gene therapy for chronic granulomatous disease.
Health-Related Quality of Life and Emotional Health in X-Linked Carriers of Chronic Granulomatous Disease in the United Kingdom.
HIF-1?-regulated MIF activation and Nox2-dependent ROS generation promote Leishmania amazonensis killing by macrophages under hypoxia.
HSCT in two brothers with CGD arising from mutations in CYBC1 corrects the defect in neutrophil function.
Identification of Cytochrome b-245, beta-chain gene mutations, and clinical presentations in Iranian patients with X-linked chronic granulomatous disease.
Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.
Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway.
Immune-related redox metabolism of embryonic cells of the tick Rhipicephalus microplus (BME26) in response to infection with Anaplasma marginale.
Impaired respiratory burst contributes to infections in PKC?-deficient patients.
Improved superoxide-generating ability by interferon gamma due to splicing pattern change of transcripts in neutrophils from patients with a splice site mutation in CYBB gene.
In vivo role of myeloperoxidase for the host defense.
Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense.
Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS.
Interactions between electron and proton currents in excised patches from human eosinophils.
Intersecting Stories of the Phagocyte NADPH Oxidase and Chronic Granulomatous Disease.
Interstitial lung disease in a patient with chronic granulomatous disease.
Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung.
Leishmania pifanoi amastigotes avoid macrophage production of superoxide by inducing heme degradation.
Lipopolysaccharide primes the respiratory burst of Atlantic salmon SHK-1 cells through protein kinase C-mediated phosphorylation of p47phox.
Listeriolysin O suppresses phospholipase C-mediated activation of the microbicidal NADPH oxidase to promote Listeria monocytogenes infection.
Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth.
Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis elegans.
Macrophages inhibit Salmonella typhimurium replication through MEK/ERK kinase and phagocyte NADPH oxidase activities.
MAMP and DAMP signalling contributes resistance to Fusarium graminearum in Arabidopsis.
Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation.
Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes.
Midgut immune responses induced by bacterial infection in the silkworm, Bombyx mori.
Molecular dynamics study on the ligand recognition by tandem SH3 domains of p47phox, regulating NADPH oxidase activity.
Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection.
NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction.
NAD(P)H oxidase in human fetal membrane chorion laeve trophoblasts with or without chorioamnionitis: ultrastructural enzyme histochemical study.
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.
NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection.
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?
Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish.
NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide.
NOX2 Deficiency Permits Sustained Survival of S. aureus in Macrophages and Contributes to Severity of Infection.
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells.
Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase.
Oxidative killing of microbes by neutrophils.
p47(phox) Directs Murine Macrophage Cell Fate Decisions.
Parasitic worms stimulate host NADPH oxidases to produce reactive oxygen species that limit plant cell death and promote infection.
Pathogenic Effects of IFIT2 and Interferon-? during Fatal Systemic Candida albicans Infection.
Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42.
Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice.
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections.
Plant parasitic cyst nematodes redirect host indole metabolism via NADPH oxidase-mediated ROS to promote infection.
Protein disulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promastigotes by macrophages.
Puerarin Attenuates High Glucose and Diabetes-induced Vascular Smooth Muscle Cell Proliferation Via Blocking PKC-beta2/Rac-1-Dependent Signaling.
Quantitative live-cell imaging and 3D modeling reveal critical functional features in the cytosolic complex of phagocyte NADPH oxidase.
RbohB, a Phaseolus vulgaris NADPH oxidase gene, enhances symbiosome number, bacteroid size, and nitrogen fixation in nodules and impairs mycorrhizal colonization.
Recurrent infections with Aspergillus require exclusion of defects in the phagocyte NADPH oxidase pathway.
Redundant hydrogen peroxide scavengers contribute to Salmonella virulence and oxidative stress resistance.
Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia.
Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus.
Respiratory Burst Oxidase Homologs RBOHD and RBOHF as Key Modulating Components of Response in Turnip Mosaic Virus-Arabidopsisthaliana (L.) Heyhn System.
Responses to reactive oxygen intermediates and virulence of Salmonella typhimurium.
RNA interference of dual oxidase in the plant nematode Meloidogyne incognita.
Role for inducible nitric oxide synthase in protection from chronic Chlamydia trachomatis urogenital disease in mice and its regulation by oxygen free radicals.
Role of pollen NAD(P)H oxidase in allergic inflammation.
Roles of superoxide anion and hydrogen peroxide during replication of two unrelated plant RNA viruses in Nicotiana benthamiana.
RtxA1-induced expression of the small GTPase Rac2 plays a key role in the pathogenicity of Vibrio vulnificus.
Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity.
Speculations on the activation of ROS generation in C. elegans innate immune signaling.
Structure of the TPR domain of p67phox in complex with Rac.GTP.
The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism.
The effect of captopril on the expression of MMP-9 and the prognosis of neurological function in herpes simplex encephalitis mice.
The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.
The Overactivation of NADPH Oxidase during Clonorchis sinensis Infection and the Exposure to N-Nitroso Compounds Promote Periductal Fibrosis.
The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.
The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii.
The role of reactive oxygen intermediates in experimental coccidioidomycois in mice.
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism.
Tissue Tropism in Streptococcal Infection: Wild-Type M1T1 Group A Streptococcus Is Efficiently Cleared by Neutrophils Using an NADPH Oxidase-Dependent Mechanism in the Lung but Not in the Skin.
Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway.
Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages.
Unraveling the role of H3K4 trimethylation and lncRNA HOTAIR in SATB1 and DUSP4-dependent survival of virulent Mycobacterium tuberculosis in macrophages.
Uracil-induced signaling pathways for DUOX-dependent gut immunity.
Using ROS as a Second Messenger, NADPH Oxidase 2 Mediates Macrophage Senescence via Interaction with NF-?B during Pseudomonas aeruginosa Infection.
Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice.
[Role of myeloperoxidase in the host defense against fungal infection]
[The Nox/Duox family of ROS-generating NADPH oxidases]
Inflammatory Bowel Diseases
Association between p47phox pseudogenes and inflammatory bowel disease.
Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties.
DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.
Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease.
First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease.
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
Functional Characterization of DUOX Enzymes in Reconstituted Cell Models.
Genetic disorders coupled to ROS deficiency.
Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.
Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor.
NADPH oxidases and cancer.
Influenza, Human
An absence of reactive oxygen species improves the resolution of lung influenza infection.
Dual oxidase 1 promotes antiviral innate immunity.
Duox2-induced innate immune responses in the respiratory epithelium and intranasal delivery of Duox2 DNA using polymer that mediates immunization.
Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages.
Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS.
Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung.
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.
NADPH oxidases as novel pharmacologic targets against influenza A virus infection.
Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy.
Insulin Resistance
Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity.
Angiotensin II induces superoxide generation via NAD(P)H oxidase activation in isolated rat pancreatic islets.
Dealcoholized red wine reverse vascular remodeling in an experimental model of metabolic syndrome: role of NAD(P)H oxidase and eNOS activity.
Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation.
Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.
Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation.
NAD (P) H oxidase p22 phox C242T polymorphism affects LDL particle size and insulin resistance in Japanese subjects.
NADPH oxidase activation by hyperglycemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in post-infarct heart failure.
Redox Regulation of Metabolic Syndrome: Recent Developments in Skeletal Muscle Insulin Resistance and Non-alcoholic Fatty Liver Disease (NAFLD).
Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.
The renin-angiotensin-aldosterone system, glucose metabolism and diabetes.
Intellectual Disability
Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice, a pathological model for Fragile X syndrome.
Intracranial Hemorrhages
Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage.
Invasive Fungal Infections
Phellinus tropicalis abscesses in a patient with chronic granulomatous disease.
Invasive Pulmonary Aspergillosis
Enhanced generation of reactive oxygen species by interferon-? may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease.
Iron Deficiencies
Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration.
Iron Overload
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Ischemic Attack, Transient
DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice.
Ischemic Stroke
From single drug targets to synergistic network pharmacology in ischemic stroke.
MicroRNA-126a-5p Exerts Neuroprotective Effects on Ischemic Stroke via Targeting NADPH Oxidase 2.
NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study.
Kidney Failure, Chronic
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure.
Haplotype analysis of NAD(P)H oxidase p22 phox polymorphisms in end-stage renal disease.
Leiomyoma
Nicotinamide Adenine Dinucleotide Phosphate Oxidase Is Differentially Regulated in Normal Myometrium Versus Leiomyoma.
Leishmaniasis, Visceral
NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of visceral leishmaniasis patients.
Leprosy
Emergence of an effective adaptive cell mediated immune response to Mycobacterium leprae is not impaired in reactive oxygen intermediate-deficient mice.
Leukemia
Arsenic, cadmium, mercury and nickel stimulate cell growth via NADPH oxidase activation.
Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells.
CD34+ peripheral blood progenitors as a target for genetic correction of the two flavocytochrome b558 defective forms of chronic granulomatous disease.
Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.
GM-CSF induces expression of gp91phox and stimulates retinoic acid-induced p47phox expression in human myeloblastic leukemia cells.
Increased neutrophil respiratory burst in bcr-null mutants.
Transcriptional activation of the gp91phox NADPH oxidase subunit by TPA in HL-60 cells.
Leukemia, Myeloid
Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox.
Probing the role of the carboxyl terminus of the gp91phox subunit of neutrophil flavocytochrome b558 using site-directed mutagenesis.
Leukocytosis
Abnormal DNA methylation patterns in patients with infection?caused leukocytopenia based on methylation microarrays.
Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
Leukopenia
Abnormal DNA methylation patterns in patients with infection?caused leukocytopenia based on methylation microarrays.
Leukostasis
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
Lichen Planus
Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation.
Liver Cirrhosis
Decreased superoxide (O2-)-generating activity of blood monocytes from patients with hepatic cirrhosis.
Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis.
Liver Diseases
Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating AdipoR1 and gp91phox expression in rats.
Liver Neoplasms
Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma.
Lung Diseases
Genetic polymorphisms and susceptibility to lung disease.
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
Lung Injury
Curcumin Mitigates Radiation-induced Lung Pneumonitis and Fibrosis in Rats.
Dual Oxidase 2 in Lung Epithelia Is Essential for Hyperoxia-Induced Acute Lung Injury in Mice.
Melatonin Attenuates Upregulation of Duox1 and Duox2 and Protects against Lung Injury following Chest Irradiation in Rats.
NADPH Oxidase 2 Regulates LPS-induced Inflammation and Alveolar Remodeling in the Developing Lung.
NADPH oxidase DUOX1 sustains TGF-?1 signalling and promotes lung fibrosis.
Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy.
Lung Neoplasms
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties.
Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer.
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma.
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.
NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells.
Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells.
Paradoxical roles of dual oxidases in cancer biology.
Regulation of anoikis resistance by NADPH oxidase 4 and epidermal growth factor receptor.
Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.
Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth.
Lyme Disease
A Dityrosine Network Mediated by Dual Oxidase and Peroxidase Influences the Persistence of Lyme Disease Pathogens within the Vector.
Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase.
Lymphadenitis
Disseminated Bacillus Calmette-Guérin lymphadenitis in a patient with gp91phox (-) chronic granulomatous disease 25 years after vaccination.
Lymphoma
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway.
NADPH Oxidase 5 upregulation is associated with lymphoma aggressiveness.
Lymphoma, B-Cell
Targeting NOX 4 by petunidin improves anoxia/reoxygenation-induced myocardium injury.
Lymphoma, Non-Hodgkin
A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma.
Lymphopenia
Mice Deficient in NOX2 Display Severe Thymic Atrophy, Lymphopenia, and Reduced Lymphopoiesis in a Zymosan-Induced Model of Systemic Inflammation.
Malaria
Anopheles stephensi Dual Oxidase Silencing Activates the Thioester-Containing Protein 1 Pathway to Suppress Plasmodium Development.
DNA phasing by TA dinucleotide microsatellite length determines in vitro and in vivo expression of the gp91phox subunit of NADPH oxidase and mediates protection against severe malaria.
Immunogenic and Antioxidant Effects of a Pathogen-Associated Prenyl Pyrophosphate in Anopheles gambiae.
Superoxide-dependent and -independent pathways are involved in the transmission blocking of malaria.
Marfan Syndrome
NADPH oxidase 4 attenuates cerebral artery changes during the progression of Marfan syndrome.
Melanoma
An NAD(P)H oxidase regulates growth and transcription in melanoma cells.
Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2.
Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells.
Metabolic utilization of exogenous pyruvate by mutant p53(R175H) human melanoma cells promotes survival under glucose depletion.
NADPH oxidase 1 overexpression enhances invasion via matrix metalloproteinase-2 and epithelial-mesenchymal transition in melanoma cells.
NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression.
NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1? and p27(Kip1) expression in malignant melanoma and other human tumors.
Memory Disorders
Protective effect of resveratrol against chronic intermittent hypoxia-induced spatial memory deficits, hippocampal oxidative DNA damage and increased p47Phox NADPH oxidase expression in young rats.
Meningitis, Pneumococcal
Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis.
Mesothelioma, Malignant
Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species.
Metabolic Diseases
Genetic Deletion of NADPH Oxidase 1 Rescues Microvascular Function in Mice With Metabolic Disease.
Nitrite-mediated reduction of macrophage NADPH oxidase activity is dependent on xanthine oxidoreductase-derived nitric oxide but independent of S-nitrosation.
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.
Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.
Metabolic Syndrome
Antioxidant system response is modified by dietary fat in adipose tissue of metabolic syndrome patients.
Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C.
Dealcoholized red wine reverse vascular remodeling in an experimental model of metabolic syndrome: role of NAD(P)H oxidase and eNOS activity.
NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.
Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome.
Swimming Exercise Protects against Insulin Resistance via Regulating Oxidative Stress through Nox4 and AKT Signaling in High-Fat Diet-Fed Mice.
The Role of Reactive Oxygen Species in the Pathogenesis of Adipocyte Dysfunction in Metabolic Syndrome. Prospects of Pharmacological Correction.
Time-of-Day-Dependent Effects of Bromocriptine to Ameliorate Vascular Pathology and Metabolic Syndrome in SHR Rats Held on High Fat Diet.
[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].
Mucopolysaccharidosis III
Cytokines, neurotrophins, and oxidative stress in brain disease from mucopolysaccharidosis IIIB.
Multiple Sclerosis
Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury.
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.
Pathogenic Effects of IFIT2 and Interferon-? during Fatal Systemic Candida albicans Infection.
Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4.
Muscular Atrophy
Deletion of NAD(P)H Oxidase 2 Prevents Angiotensin II-Induced Skeletal Muscle Atrophy.
Mycoses
Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab.
Enhanced Th2 cell differentiation and function in the absence of Nox2.
Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality.
Peptide-based inhibitors of the phagocyte NADPH oxidase.
The search for a genetic defect in Polish patients with chronic granulomatous disease.
Treosulfan-based conditioning regimen in a second matched unrelated peripheral blood stem cell transplantation for a pediatric patient with CGD and invasive aspergillosis, who experienced initial graft failure after RIC.
Myeloproliferative Disorders
Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation.
Myocardial Infarction
Association between NAD(P)H oxidase p22phox gene variants and acute myocardial infarction in a Han Chinese population.
Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.
Implications of NADPH oxidase 5 in vascular diseases.
Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats.
NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction-Induced Remodeling.
Redox Regulation of Neutrophils and Monocytes in Different Types of Myocardial Infarction.
Myocardial Ischemia
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase.
nad(p)h oxidase (h2o2-forming) deficiency
A mutation located at the 5' splice junction sequence of intron 3 in the p67phox gene causes the lack of p67phox mRNA in a patient with chronic granulomatous disease.
A novel cytosolic component, p40phox, of respiratory burst oxidase associates with p67phox and is absent in patients with chronic granulomatous disease who lack p67phox.
Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells.
Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism.
Bronchocentric granulomatosis as a first clinical manifestation in an adult patient with p67phox deficiency.
Clinical features and prognoses of 23 patients with chronic granulomatous disease followed for 21 years by a single hospital in Japan.
Conformation of the N-Terminal Ectodomain Elicits Different Effects on DUOX Function: A Potential Impact on Congenital Hypothyroidism Caused by a H2O2 Production Defect.
Correction to: Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism by Dufort G, Larrivée-Vanier S, Eugène D, De Deken X, Seebauer B, Heinimann K, Lévesque S, Gravel S, Szinnai G, Van Vliet G, and Deladoëy J. Thyroid 2019;29:1018-1022.
Deficiency of gp91phox Inhibits Allergic Airway Inflammation.
Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility.
Diagnostic Modalities Based on Flow Cytometry for Chronic Granulomatous Disease: A Multicenter Study in a Well-Defined Cohort.
Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis.
Differential Transgene Silencing of Myeloid-Specific Promoters in the AAVS1 Safe Harbor Locus of Induced Pluripotent Stem Cell-Derived Myeloid Cells.
Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.
Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD).
Dose-dependent enhancements by interferon-gamma on functional responses of neutrophils from chronic granulomatous disease patients.
Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema.
Dual oxidase 1 limits the IFN?-associated antitumor effect of macrophages.
DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.
Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.
Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer.
Endothelial Function and Oxidative Stress in X-Linked, gp91phox Deficiency, Chronic Granulomatous Disease.
Exuberant inflammation in nicotinamide adenine dinucleotide phosphate-oxidase-deficient mice after allogeneic marrow transplantation.
Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs.
gp91phox-dependent expression of platelet CD40 ligand.
Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries.
In vitro interferon ? improves the oxidative burst activity of neutrophils in patients with chronic granulomatous disease with a subtype of gp91phox deficiency.
Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction.
iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells.
Mammalian NADPH Oxidases.
Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species-Studies in White Blood Cells and in Animal Models.
NADPH OXIDASE 1 DEFICIENCY ALTERS CAVEOLIN PHOSPHORYLATION AND ANGIOTENSIN II RECEPTOR LOCALIZATION IN VASCULAR SMOOTH MUSCLE.
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
NADPH oxidase 4 deficiency leads to impaired wound repair and reduced dityrosine-crosslinking, but does not affect myofibroblast formation.
NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.
Novel effect of oxidized low-density lipoprotein: cellular ATP depletion via downregulation of glyceraldehyde-3-phosphate dehydrogenase.
Opening the black box: lessons from cell-free systems on the phagocyte NADPH-oxidase.
Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase.
p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia.
p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis.
p47phox deficiency improves cognitive impairment and attenuates tau hyperphosphorylation in mouse models of AD.
p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia.
Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction.
Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease.
Renovascular hypertension by two-kidney one-clip enhances endothelial progenitor cell mobilization in a p47phox-dependent manner.
Role of p47phox in antigen-presenting cell-mediated regulation of humoral immunity in mice.
Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity.
Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells.
Subcellular localization and dynamics of components of the respiratory burst oxidase.
Sulfite stimulates NADPH oxidase of human neutrophils to produce active oxygen radicals via protein kinase C and Ca2+/calmodulin pathways.
The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.
Wide Spectrum of DUOX2 Deficiency: From Life-Threatening Compressive Goiter in Infancy to Lifelong Euthyroidism.
[Gene therapy for inherited diseases using heamatopoietic stem cells--gene therapy for patients with chronic granulomatous disease]
nadph dehydrogenase (quinone) deficiency
The three CYBA variants (rs4673, rs1049254 and rs1049255) are benign: new evidence from a patient with CGD.
Nasal Polyps
Expression of nicotinamide adenine dinucleotide phosphate oxidase in chronic rhinosinusitis with nasal polyps.
Nematode Infections
Plant parasitic cyst nematodes redirect host indole metabolism via NADPH oxidase-mediated ROS to promote infection.
Neoplasm Metastasis
A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells.
Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma.
High Immunoreactivity of DUOX2 Is Associated With Poor Response to Preoperative Chemoradiation Therapy and Worse Prognosis in Rectal Cancers.
Inhibiting cancer metastasis via targeting NAPDH oxidase 4.
Inhibition of NADPH oxidase 4 attenuates lymphangiogenesis and tumor metastasis in breast cancer.
Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression.
NOX1 mediates chemoresistance via HIF1?/MDR1 pathway in gallbladder cancer.
NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling.
Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis.
Neoplasms
(-)-Epicatechin protects thoracic aortic perivascular adipose tissue from whitening in high-fat fed mice.
4-Hydroxy-7-oxo-5-heptenoic acid lactone is a potent inducer of brain cancer cell invasiveness that may contribute to the failure of anti-angiogenic therapies.
A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells.
A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells.
A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells.
Activation of NADPH oxidase 1 in tumour colon epithelial cells.
Activation of NADPH-oxidase and its associated whole-cell H+ current in human neutrophils by recombinant human tumor necrosis factor alpha and formyl-methionyl-leucyl-phenylalanine.
Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-? and lipopolysaccharide in human pancreatic cancer cell lines.
Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4.
Administration of bovine casein-derived peptide prevents cognitive decline in Alzheimer disease model mice.
Age-associated pro-inflammatory adaptations of the mouse thoracic aorta.
Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox.
Alpha-phenyl-N-tert-butylnitrone attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats.
Antisense to protein kinase C-alpha and p47phox attenuates the pro-inflammatory effects of human C-reactive protein in macrophages of biobreeding diabetic rats.
Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNF?- and NOX2-dependent pathway.
Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension.
Blockade of TLR4 Within the Paraventricular Nucleus Attenuates Blood Pressure by Regulating ROS and Inflammatory Cytokines in Prehypertensive Rats.
Cardioprotective Effect of a Combination of Rho-Kinase Inhibitor and P38 MAPK Inhibitor on Cardiovascular Remodeling and Oxidative Stress in Dahl Rats.
Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling.
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody.
Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.
Clinicopathological and prognostic value of NADPH oxidase 2 (NOX2) in primary osteosarcoma.
Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer.
Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction.
Decoding NADPH oxidase 4 expression in human tumors.
Dual oxidase 1 limits the IFN?-associated antitumor effect of macrophages.
Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
DUOX1 in mammalian disease pathophysiology.
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties.
DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
DUOX2 As a Potential Prognostic Marker which Promotes Cell Motility and Proliferation in Pancreatic Cancer.
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon.
DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3.
DUOX2, a New Biomarker for Disseminated Gastric Cancer's Response to Low Dose Radiation in Mice.
Effect of Chenodeoxycholic Acid on Fibrosis, Inflammation and Oxidative Stress in Kidney in High-Fructose-Fed Wistar Rats.
Effect of mate tea (Ilex paraguariensis) on the expression of the leukocyte NADPH oxidase subunit p47phox and on circulating inflammatory cytokines in healthy men: a pilot study.
Effect of pioglitazone on insulin resistance in fructose-drinking rats correlates with AGEs/RAGE inhibition and block of NADPH oxidase and NF kappa B activation.
Effects of oral estrogen on aortic ROS-generating and -scavenging enzymes and atherosclerosis in apoE-deficient mice.
Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells.
Effects of trehalose supplementation on the growth performance and intestinal innate immunity of juvenile chicks.
Enhanced Cerebral Microbleeds by Long-Term Air Pollution Exposure in Spontaneously Hypertensive Rats.
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma.
Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation.
Exenatide ameliorates inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes.
Exercise, vascular wall and cardiovascular diseases: an update (Part 1).
Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues.
Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.
Farnesyltransferase inhibitors reduce ras activation and ameliorate acetaminophen-induced liver injury in mice.
Ferulic Acid Alleviates Changes in a Rat Model of Metabolic Syndrome Induced by High-Carbohydrate, High-Fat Diet.
Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88.
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
G protein-coupled receptor kinase 2 modifies the cellular reaction to cisplatin through interactions with NADPH oxidase 4.
Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma.
Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation.
Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst.
High Immunoreactivity of DUOX2 Is Associated With Poor Response to Preoperative Chemoradiation Therapy and Worse Prognosis in Rectal Cancers.
High nuclear NADPH oxidase 4 expression levels are correlated with cancer development and poor prognosis in hepatocellular carcinoma.
Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period.
Identification of a novel tumor necrosis factor alpha-responsive region in the NCF2 promoter.
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells.
In vitro effects of Escherichia coli lipopolysaccharide on the function and gene expression of neutrophils isolated from the blood of dairy cows.
Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase.
Induction of expression of genes encoding components of the respiratory burst oxidase during differentiation of human myeloid cell lines induced by tumor necrosis factor and gamma-interferon.
Influence of the periprostatic adipose tissue in obesity-associated mouse urethral dysfunction and oxidative stress: Effect of resveratrol treatment.
Inhibiting cancer metastasis via targeting NAPDH oxidase 4.
Inhibition of NADPH oxidase 4 attenuates lymphangiogenesis and tumor metastasis in breast cancer.
Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.
Inhibition of TNF-? in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by inhibiting neurohormonal excitation in spontaneously hypertensive rats.
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
Insilico study of genes involved in Congenital Hypothyroidism.
Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon.
Interleukin-18 primes the oxidative burst of neutrophils in response to formyl-peptides: role of cytochrome b558 translocation and N-formyl peptide receptor endocytosis.
Interplay between Numb and Notch in epithelial cancers: role for dual oxidase maturation factor.
Intratracheal transplantation of human umbilical cord blood derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats.
Invasive Pathobionts Contribute to Colon Cancer Initiation by Counterbalancing Epithelial Antimicrobial Responses.
Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth.
Lipid Raft-dependent Activation of Dual Oxidase-1-H2O2-NF-kappaB Pathway in Bronchial Epithelial Cells.
Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression.
Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats.
Modulation of oxidative/nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia/reperfusion: The role of mTOR.
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats.
Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice.
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
NADPH oxidase 1 is highly expressed in human large and small bowel cancers.
NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.
NADPH oxidase 4 is correlated with gastric cancer progression and predicts a poor prognosis.
NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1? and p27(Kip1) expression in malignant melanoma and other human tumors.
NADPH Oxidase 5 upregulation is associated with lymphoma aggressiveness.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.
NADPH oxidases and cancer.
Negative correlation between thyroperoxidase and dual oxidase H2O2-generating activities in thyroid nodular lesions.
Nicotinamide prevents sweet beverage-induced hepatic steatosis in rats by regulating the G6PD, NADPH/NADP
No association between genetic polymorphisms in NAD(P)H oxidase p22phox and paraoxonase 1 and colorectal cancer risk.
Novel, Small Molecule induced GABA-hATSCs for Targeting of Neuropathic Pain.
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.
NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling.
NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells.
NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway.
Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice.
Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer.
Oxidant-resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1.
Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype.
P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK.
Paradoxical roles of dual oxidases in cancer biology.
Pathogenic Effects of IFIT2 and Interferon-? during Fatal Systemic Candida albicans Infection.
Peculiarities of antioxidant system and iron metabolism in organism during development of tumor resistance to cisplatin.
Plasma Messenger RNAs Identified Through Bioinformatics Analysis are Novel, Non-Invasive Prostate Cancer Biomarkers.
Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice.
Priming by tumor necrosis factor-alpha of human neutrophil NADPH-oxidase activity induced by anti-proteinase-3 or anti-myeloperoxidase antibodies.
Reactive oxygen species as mediators of angiogenesis signaling: role of NAD(P)H oxidase.
Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure.
Redox regulation of cytokeratin 18 protein by NADPH oxidase 1 in preneoplastic human epithelial cells.
Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin.
Redox-regulation of gelatinases during growth of cisplatin-sensitive and resistant Guerin carcinoma.
Regulation of normal cell cycle progression by flavin-containing oxidases.
Remnant lipoprotein particles induce apoptosis in endothelial cells by NAD(P)H oxidase-mediated production of superoxide and cytokines via lectin-like oxidized low-density lipoprotein receptor-1 activation: prevention by cilostazol.
Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.
Right-side and left-side colon cancer follow different pathways to relapse.
RNAi-mediated silencing of NOX4 inhibited the invasion of gastric cancer cells through JAK2/STAT3 signaling.
Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells.
Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha.
ROS-generating oxidase NOX1 promotes the self-renewal activity of CD133+ thyroid cancer cells through activation of the Akt signaling.
Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-?B/TNF-?/NOX/iNOS Pathway.
Setanaxib as a Potent Hypoxia-specific Therapeutic Agent Against Liver Cancer.
Sheep erythrocytes provide metabolic triggers for tumour phagocytosis in polymorphonuclear neutrophils: a possible mechanism of tumour inhibition in mice.
SIRT1-NOX4 signaling axis regulates cancer cachexia.
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.
Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPAR? mediated mechanism.
Tetrahydrocurcumin Ameliorates Skin Inflammation by Modulating Autophagy in High-Fat Diet-Induced Obese Mice.
The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells.
The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway.
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation.
Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4.
TNF-alpha blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats.
Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.
Tumor necrosis factor-?-induced colitis increases NADPH oxidase 1 expression, oxidative stress, and neutrophil recruitment in the colon: preventive effect of apocynin.
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms.
Tumor-induced endothelial cell apoptosis: roles of NAD(P)H oxidase-derived reactive oxygen species.
Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth.
Tumour necrosis factor (TNF)-alpha primes murine neutrophils when triggered via formyl peptide receptor-related sequence 2, the murine orthologue of human formyl peptide receptor-like 1, through a process involving the type I TNF receptor and subcellular granule mobilization.
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4.
Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-{gamma} (IFN-{gamma})-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines.
Vascular endothelial function is improved by oral glycine treatment in aged rats.
VEGF-induced ROS generation from NAD(P)H oxidases protects human leukemic cells from apoptosis.
[Effects of a nitric oxide donor, the substratum of NO-synthase, and an inhibitor of NO-synthase on the ROS-generation activity of phagocytes in the course of ascites tumor growth].
[Effects of aerobic interval training on myocardial oxidative stress and inflammation in rats with myocardial infarction and its mechanism].
[Phenolic antioxidant TS-13 regulating ARE-dependent genes induces tumor cell death by mitochondria-dependent pathway].
Nephrolithiasis
Patients with nephrolithiasis had lower fetuin-A protein level in urine and renal tissue.
Nervous System Diseases
NADPH-oxidase activation and cognition in Alzheimer's disease progression.
The role of NOX inhibitors in neurodegenerative diseases.
Neural Tube Defects
miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4.
Neuralgia
MiR23b Ameliorates Neuropathic Pain in Spinal Cord by Silencing NADPH Oxidase 4.
Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord.
Novel, Small Molecule induced GABA-hATSCs for Targeting of Neuropathic Pain.
Nox4-dependent upregulation of S100A4 after peripheral nerve injury modulates neuropathic pain processing.
RETRACTED: miR23b ameliorates neuropathic pain in spinal cord by silencing NADPH oxidase 4.
Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.
Neuroblastoma
Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.
Silencing of NADPH oxidase 4 attenuates hypoxia resistance in neuroblastoma cells SHSY-5Y by inhibiting PI3K/Akt-dependent glycolysis.
Neurodegenerative Diseases
Dexmedetomidine Protects Against Chemical Hypoxia-Induced Neurotoxicity in Differentiated PC12 Cells Via Inhibition of NADPH Oxidase 2-Mediated Oxidative Stress.
Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2.
Role of oxidative stress in the natriuresis induced by central administration of angiotensin II.
Neuroinflammatory Diseases
Dexmedetomidine Alleviates Hypoxia-Induced Synaptic Loss and Cognitive Impairment via Inhibition of Microglial NOX2 Activation in the Hippocampus of Neonatal Rats.
Inhibition of lysophosphatidic acid receptor 1 attenuates neuroinflammation via PGE2/EP2/NOX2 signalling and improves the outcome of intracerebral haemorrhage in mice.
Involvement of the Microglial Aryl Hydrocarbon Receptor in Neuroinflammation and Vasogenic Edema after Ischemic Stroke.
Neutropenia
Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells.
Newcastle Disease
The in vitro effects of Newcastle disease virus on the metabolic and antibacterial functions of human neutrophils.
Non-alcoholic Fatty Liver Disease
Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population.
Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.
Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease.
Nobiletin alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating AdipoR1 and gp91phox expression in rats.
Redox Regulation of Metabolic Syndrome: Recent Developments in Skeletal Muscle Insulin Resistance and Non-alcoholic Fatty Liver Disease (NAFLD).
Obesity
Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity.
Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity.
Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity.
Effect of Early Particulate Air Pollution Exposure on Obesity in Mice. Role of p47phox.
Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.
Female Mice Lacking p47phox Have Altered Adipose Tissue Gene Expression and are Protected Against High Fat-Induced Obesity.
Maternal Diet-Induced Obesity Compromises Oxidative Stress Status and Angiogenesis in the Porcine Placenta by Upregulating Nox2 Expression.
Microvascular Endothelial Dysfunction in Human Obesity: Role of TNF-?.
NAD(P)H oxidase activation: a potential target mechanism for diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.
NADPH Oxidase 2 Mediates Myocardial Oxygen Wasting in Obesity.
NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness.
Oxidative stress in response to saturated fat ingestion is linked to insulin resistance and hyperandrogenism in PCOS.
Systemic upregulation of NADPH oxidase in diet-induced obesity in rats.
[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].
Osteoarthritis
Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis.
Advanced oxidation protein products increase TNF-? and IL-1? expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression.
p47phox siRNA-Loaded PLGA Nanoparticles Suppress ROS/Oxidative Stress-Induced Chondrocyte Damage in Osteoarthritis.
Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis.
Superoxide production by polymorphonuclear leucocytes in rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase.
Osteoarthritis, Knee
The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2.
Osteoporosis
NADPH oxidase 4 represents a potential target for the treatment of osteoporosis.
Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.
Osteosarcoma
Clinicopathological and prognostic value of NADPH oxidase 2 (NOX2) in primary osteosarcoma.
Inhibition of NADPH oxidase 2 induces apoptosis in osteosarcoma: The role of reactive oxygen species in cell proliferation.
Ovarian Neoplasms
DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer.
Pancreatic Neoplasms
Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-? and lipopolysaccharide in human pancreatic cancer cell lines.
Dual Oxidase2 and pancreatic adenocarcinoma: IFN-?-mediated dual oxidase2 overexpression results in H2O2-induced, ERKassociated up-regulation of HIF-1? and VEGF-A.
DUOX2 As a Potential Prognostic Marker which Promotes Cell Motility and Proliferation in Pancreatic Cancer.
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells.
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells.
Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
Up-regulation and Sustained Activation of Stat1 Are Essential for Interferon-{gamma} (IFN-{gamma})-induced Dual Oxidase 2 (Duox2) and Dual Oxidase A2 (DuoxA2) Expression in Human Pancreatic Cancer Cell Lines.
Pancreatitis, Chronic
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody.
NADPH oxidase 1 mediates caerulein-induced pancreatic fibrosis in chronic pancreatitis.
NADPH oxidases and cancer.
Parasitic Diseases
Molecular cloning and characterisation of ovine dual oxidase 2.
Parkinson Disease
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.
Aging, Angiotensin system and dopaminergic degeneration in the substantia nigra.
NADPH oxidase 1 mediates ?-synucleinopathy in Parkinson's disease.
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Park 7: A Novel Therapeutic Target for Macrophages in Sepsis-Induced Immunosuppression.
Pleurisy
Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation.
Pneumonia
Formaldehyde induces lung inflammation by an oxidant and antioxidant enzymes mediated mechanism in the lung tissue.
Genetic Phagocyte NADPH Oxidase Deficiency Enhances Nonviable Candida albicans-Induced Inflammation in Mouse Lungs.
Metformin Protects Against Radiation-Induced Pneumonitis and Fibrosis and Attenuates Upregulation of Dual Oxidase Genes Expression.
NADPH-oxidase but not inducible nitric oxide synthase contributes to resistance in a murine Staphylococcus aureus Newman pneumonia model.
NOX2 in lung inflammation: quantum dot based in situ imaging of NOX2-mediated expression of vascular cell adhesion molecule-1.
p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia.
p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia.
Pathogenicity of environmental isolates of V. cholerae in mice.
Polyneuropathies
NADPH oxidase 2 (NOX2) enzyme activation in patients with chronic inflammatory demyelinating polyneuropathy.
Polyuria
Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets.
Porcine Reproductive and Respiratory Syndrome
Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism.
Pre-Eclampsia
Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies.
NAD(P)H oxidase associated superoxide production in human placenta from normotensive and pre-eclamptic women.
Oxidative stress and preeclampsia: rationale for antioxidant clinical trials.
Vitamin E in preeclampsia.
[Disbalance of redox processes in amniotic fluid at pre-eclampsia.]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors.
Primary Immunodeficiency Diseases
Activation of cryptic splice sites in three patients with chronic granulomatous disease.
Advances in the diagnosis and treatment of chronic granulomatous disease.
Mammalian NADPH Oxidases.
Prostatic Neoplasms
Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells.
Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer.
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.
Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype.
Proteinuria
Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats.
NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE.
Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney.
Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets.
Role of intra-renal angiotensin system activation, oxidative stress, inflammation and impaired Nrf2 activity in the progression of focal glomerulosclerosis.
Pseudomonas Infections
Using ROS as a Second Messenger, NADPH Oxidase 2 Mediates Macrophage Senescence via Interaction with NF-?B during Pseudomonas aeruginosa Infection.
Psoriasis
Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish.
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.
Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation.
[Expression of DUOX2 in psoriasis and atopic dermatitis lesion].
Pulmonary Arterial Hypertension
Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model.
Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension.
Pulmonary Disease, Chronic Obstructive
A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells.
Cigarette smoke extract amplifies NADPH oxidase-dependent ROS production to inactivate PTEN by oxidation in BEAS-2B cells.
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Dual oxidase 1 and 2 expression in airway epithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease.
Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.
Increased Cytokine Response of Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease.
NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild-moderate ex-smoker COPD patients with persistent oxidative stress.
Pulmonary Fibrosis
A Positive Feed Forward Loop between Wnt/?-Catenin and NOX4 Promotes Silicon Dioxide-Induced Epithelial-Mesenchymal Transition of Lung Epithelial Cells.
Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis.
Characterisation of nox4 inhibitors from edible plants.
NADPH oxidase DUOX1 sustains TGF-?1 signalling and promotes lung fibrosis.
NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis.
Real-Time Evaluation of Hydrogen Peroxide Injuries in Pulmonary Fibrosis Mice Models with a Mitochondria-Targeted Near-Infrared Fluorescent Probe.
Synergistic protection of Schizandrin B and Glycyrrhizic acid against bleomycin-induced pulmonary fibrosis by inhibiting TGF-?1/Smad2 pathways and overexpression of NOX4.
Rectal Neoplasms
High Immunoreactivity of DUOX2 Is Associated With Poor Response to Preoperative Chemoradiation Therapy and Worse Prognosis in Rectal Cancers.
Renal Insufficiency
[Effects of Jianpi Qinghua Recipe on angiotensin II/NADPH oxidase pathway in 5/6 nephrectomized rats].
Renal Insufficiency, Chronic
[Remodeling of the cardiovascular system and development of chronic kidney disease in patients with metabolic syndrome and obesity: role of eNOS, subunit p22-phox of NADPH-oxidase and MTHFR genes].
Reperfusion Injury
Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors.
Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats.
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
Respiratory Distress Syndrome
Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analogue U46619, 8-isoprostane F2alpha, prostaglandin F2alpha, cytokines and endotoxin in the pig pulmonary artery.
Retinal Detachment
RNA interference targeting NOX4 protects visual function in an experimental model of retinal detachment by alleviating blood-retinal barrier damage.
Retinal Neovascularization
Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy.
Retinoblastoma
The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway.
Retinopathy of Prematurity
Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model.
Endothelial NADPH oxidase 4 mediates vascular endothelial growth factor receptor 2-induced intravitreal neovascularization in a rat model of retinopathy of prematurity.
Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity.
Salmonella Infections
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.
Scleroderma, Systemic
Increased expression of NAPDH oxidase 4 in systemic sclerosis dermal fibroblasts: regulation by transforming growth factor ?.
Sepsis
Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood-brain barrier in mice.
Endogenous Hydrogen Sulfide Ameliorates NOX4 Induced Oxidative Stress in LPS-Stimulated Macrophages and Mice.
Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis.
Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target.
NOX2 decoy peptides disrupt trauma-mediated neutrophil immunosuppression and protect against lethal peritonitis.
Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease.
Superoxide production in the vasculature of lipopolysaccharide-treated rats and pigs.
Severe Combined Immunodeficiency
Structure-function effects in primary immunodeficiencies.
Silicosis
A Positive Feed Forward Loop between Wnt/?-Catenin and NOX4 Promotes Silicon Dioxide-Induced Epithelial-Mesenchymal Transition of Lung Epithelial Cells.
Sleep Apnea Syndromes
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.
C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model.
Sleep Apnea, Obstructive
Intermittent Hypoxia Induced Formation of "Endothelial Cell-Colony Forming Units (EC-CFUs)" Is Affected by ROS and Oxidative Stress.
Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population.
Small Cell Lung Carcinoma
NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines.
small monomeric gtpase deficiency
The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria.
Spinal Cord Injuries
Altered oxidative stress and antioxidant defence in skeletal muscle during the first year following spinal cord injury.
Effects of nerve graft on nitric oxide synthase, NAD(P)H oxidase, and antioxidant enzymes in chronic spinal cord injury.
NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury.
Spondylarthropathies
NADPH oxidase priming and p47phox phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis and spondylarthropathy.
Squamous Cell Carcinoma of Head and Neck
Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.
Status Epilepticus
Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage.
Stomach Neoplasms
Contribution of Dual Oxidase 2 (DUOX2) to Hyper-Radiosensitivity in Human Gastric Cancer Cells.
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon.
DUOX2, a New Biomarker for Disseminated Gastric Cancer's Response to Low Dose Radiation in Mice.
Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells.
NADPH oxidase 4 is correlated with gastric cancer progression and predicts a poor prognosis.
NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR.
Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer.
Stroke
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases.
Expression of Endothelial NOX5 Alters the Integrity of the Blood-Brain Barrier and Causes Loss of Memory in Aging Mice.
Implications of NADPH oxidase 5 in vascular diseases.
NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama study.
NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke.
Novel isoforms of NADPH-oxidase in cerebral vascular control.
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
Role of neuronal NADPH oxidase 1 in the peri-infarct regions after stroke.
[The relationship between the exon 10 of the p47(phox) polymorphism and stroke and the effect of the polymorphism on plasma lipid.]
Subarachnoid Hemorrhage
Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice.
Vascular NAD(P)H oxidase triggers delayed cerebral vasospasm after subarachnoid hemorrhage in rats.
Synovitis
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
Thrombosis
Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis.
Inhibition of NADPH oxidase blocks NETosis and reduces thrombosis in heparin-induced thrombocytopenia.
NADPH oxidase 2 (NOX2): A key target of oxidative stress-mediated platelet activation and thrombosis.
p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis.
Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS.
Thyroid Diseases
Dual oxidase, hydrogen peroxide and thyroid diseases.
Thyroid Dysgenesis
DUOX2 and DUOXA2 Variants Confer Susceptibility to Thyroid Dysgenesis and Gland-in-situ With Congenital Hypothyroidism.
DUOX2 Mutations Are Associated With Congenital Hypothyroidism With Ectopic Thyroid Gland.
Genetics of primary congenital hypothyroidism-a review.
Thyroid Neoplasms
Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.
Genetic Variants Implicate Dual Oxidase-2 (DUOX2) in Familial and Sporadic Non-Medullary Thyroid Cancer.
Thyroiditis
Pioglitazone, a PPAR? Agonist, Upregulates the Expression of Caveolin-1 and Catalase, Essential for Thyroid Cell Homeostasis: A Clue to the Pathogenesis of Hashimoto's Thyroiditis.
Toxoplasmosis
NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against Toxoplasma gondii infection.
Tuberculosis
ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.
Disseminated Tuberculosis in a Patient with Autosomal Recessive p47phox Chronic Granulomatous Disease.
Mycobacterium tuberculosis PPE2 Protein Interacts with p67phox and Inhibits Reactive Oxygen Species Production.
Uremia
Vascular sources of oxidative stress: implications for uremia-related cardiovascular disease.
Urinary Bladder Neoplasms
DUOX2 promotes the elimination of the Klebsiella pneumoniae strain K5 from T24 cells through the reactive oxygen species pathway.
Uterine Cervical Neoplasms
Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.
Uveitis
NAD(P)H oxidase regulates CCL2 production during retinal inflammation.
Varicose Veins
Compression stockings attenuate the expression of proteins associated with vascular damage in human varicose veins.
Vascular Calcification
Advanced Glycation End Products-induced Vascular Calcification is Mediated by Oxidative Stress: Functional Roles of NAD(P)H-oxidase.
Superoxide production: a procalcifying cell signalling event in osteoblastic differentiation of vascular smooth muscle cells exposed to calcification media.
Vascular Remodeling and Arterial Calcification Are Directly Mediated by S100A12 (EN-RAGE) in Chronic Kidney Disease.
Vascular Diseases
Cyclic strain induces reactive oxygen species production via an endothelial NAD(P)H oxidase.
Ethers and esters derived from apocynin avoid the interaction between p47phox and p22phox subunits of NADPH oxidase: evaluation in vitro and in silico.
Hypoxic vascular response and ventilation/perfusion matching in end-stage COPD may depend on p22phox.
Implications of NADPH oxidase 5 in vascular diseases.
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways.
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology.
Vascular NAD(P)H oxidase as a novel therapeutic target in vascular disease.
Vascular System Injuries
Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury.
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: involvement of the renin-angiotensin system.
NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities.
Oxidative-nitrosative stress in hypertension.
Superoxide production in the vasculature of lipopolysaccharide-treated rats and pigs.
The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice.
Vasospasm, Intracranial
Vascular NAD(P)H oxidase triggers delayed cerebral vasospasm after subarachnoid hemorrhage in rats.
Venous Thrombosis
p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis.
Ventilator-Induced Lung Injury
Role of Dual Oxidases in Ventilator-induced Lung Injury.
Ventricular Dysfunction, Left
Statins ameliorate pulmonary hypertension secondary to left ventricular dysfunction through the Rho-kinase pathway and NADPH oxidase.
Trimetazidine prevents diabetic cardiomyopathy by inhibiting Nox2/TRPC3-induced oxidative stress.
Virus Diseases
Dual oxidase 1 promotes antiviral innate immunity.
Duox2-induced innate immune responses in the respiratory epithelium and intranasal delivery of Duox2 DNA using polymer that mediates immunization.
Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung.
NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.
Pathogenic Effects of IFIT2 and Interferon-? during Fatal Systemic Candida albicans Infection.
The in vitro effects of Newcastle disease virus on the metabolic and antibacterial functions of human neutrophils.
The NLRP3 Inflammasome and IL-1? Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis.
Vitamin D Deficiency
Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice.
Whooping Cough
Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells.
Polymorphonuclear leukocytes activation: in vitro modulation by 6-methoxy-2-naphthylacetic acid, the major active metabolite of nabumetone.
Williams Syndrome
Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.