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Information on EC 1.5.8.4 - dimethylglycine dehydrogenase and Organism(s) Mus musculus and UniProt Accession Q9DBT9

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IUBMB Comments
A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].
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This record set is specific for:
Mus musculus
UNIPROT: Q9DBT9
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dimethylglycine dehydrogenase, dmgdh, me2glydh, csal_0990, n,n-dimethylglycine oxidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Me2GlyDH
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N,N-dimethylglycine oxidase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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oxidative deamination
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].
CAS REGISTRY NUMBER
COMMENTARY hide
37256-30-7
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
M2GD_MOUSE
869
0
97255
Swiss-Prot
Mitochondrion (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pyo, J.O.; Nah, J.; Kim, H.J.; Chang, J.W.; Song, Y.W.; Yang, D.K.; Jo, D.G.; Kim, H.R.; Chae, H.J.; Chae, S.W.; Hwang, S.Y.; Kim, S.J.; Kim, H.J.; Cho, C.; Oh, C.G.; Park, W.J.; Jung, Y.K.
Protection of cardiomyocytes from ischemic/hypoxic cell death via Drbp1 and pMe2GlyDH in cardio-specific ARC transgenic mice
J. Biol. Chem.
283
30707-30714
2008
Mus musculus (Q9DBT9), Mus musculus
Manually annotated by BRENDA team