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(R)-4-(1-methylpyrrolidine-2-yl)phenol + H2O + O2
? + H2O2
Q8GAG1
-
-
-
?
(R)-6-aminonicotine + H2O + O2
1-(-aminopyridin-3-yl)-4-methylamino-butan-1-one + H2O2
-
-
-
-
?
(R)-6-chloronicotine + H2O + O2
4-amino-1-(6-chloropyridin-3-yl)-butan-1-one + H2O2
Q8GAG1
-
-
-
?
(R)-6-hydroxynicotine + H2O + electron acceptor
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + electron donor
-
as electron acceptors methylene blue and 2,6-dichlorophenolindophenol aerobically and anaerobically
-
?
(R)-6-hydroxynicotine + H2O + O2
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
(R)-6-hydroxynornicotine + H2O + O2
4-amino-1-(6-hydroxypyridin-3-yl)-butan-1-one + H2O2
Q8GAG1
-
-
-
?
(R)-nicotine + H2O + O2
1-(pyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
Q8GAG1
-
-
-
?
6-hydroxy-nornicotine + H2O + O2
4-amino-1-(6-hydroxypyridin-3-yl)-butan-1-one + H2O2
-
-
-
-
?
additional information
?
-
(R)-6-hydroxynicotine + H2O + O2
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
-
392431, 392434, 392435, 392436, 392438, 392439, 392440, 392441, 392443, 392445, 392446, 392447, 392449, 392450, 392451, 392452, 392453, 392454, 392456, 392457, 392460, 392461, 392462 -
-
?
(R)-6-hydroxynicotine + H2O + O2
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
Q8GAG1
-
-
-
?
(R)-6-hydroxynicotine + H2O + O2
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
-
transcient product is 6-hydroxy-N-methylmyosmine that hydrolyses spontaneously
?
(R)-6-hydroxynicotine + H2O + O2
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
-
transcient product is 6-hydroxy-N-methylmyosmine that hydrolyses spontaneously
?
(R)-6-hydroxynicotine + H2O + O2
1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + H2O2
-
-
transcient product is 6-hydroxy-N-methylmyosmine that hydrolyses spontaneously
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
enzyme production is induced by growing cells in D,L-nicotine as only source of carbon and nitrogen
-
-
?
additional information
?
-
-
enzyme production is induced by growing cells in D,L-nicotine as only source of carbon and nitrogen
-
-
?
additional information
?
-
-
enzyme production is induced by growing cells in D,L-nicotine as only source of carbon and nitrogen
-
-
?
additional information
?
-
-
it is synthesized only during the late logarithmic or early stationary phases of growth
-
-
?
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Schenk, S.; Hoelz, A.; Krauss, B.; Decker, K.
Gene structures and properties of enzymes of the plasmid-encoded nicotine catabolism of Arthrobacter nicotinovorans
J. Mol. Biol.
284
1323-1339
1998
Paenarthrobacter nicotinovorans
brenda
Grether-Beck, S.; Igloi, G.L.; Pust, S.; Schilz, E.; Decker, K.; Brandsch, R.
Structural analysis and molybdenum-dependent expression of the pAO1-encoded nicotine dehydrogenase genes of Arthrobacter nicotinovorans
Mol. Microbiol.
13
929-936
1994
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Hinkkanen, A.E.; Mauch, L.; Nagursky, H.; Decker, K.
6-Hydroxy-D-nicotine oxidase of Arthrobacter oxidans. Gene structure of the flavoenzyme and its relationship to 6-hydroxy-L-nicotine oxidase
Eur. J. Biochem.
167
315-320
1987
Paenarthrobacter nicotinovorans
brenda
Swafford, J.R.; Reeves, H.C.; Brandsch, R.
Localization of the enantiozymes of 6-hydroxy-nicotine oxidase in Arthrobacter oxidans by electron immunochemistry
J. Bacteriol.
163
792-795
1985
Paenarthrobacter nicotinovorans
brenda
Hinkkanen, A.; Lilius, E.M.; Nowack, J.; Maas, R.; Decker, K.
Purification of the flavoproteins 6-hydroxy-D- and 6-hydroxy-L-nicotine oxidase using hydrophobic affinity chromatography
Hoppe-Seyler's Z. Physiol. Chem.
364
801-806
1983
Paenarthrobacter nicotinovorans
brenda
Decker, K.; Dai, V.D.; Mhler, H.; Bruhmuller, M.
D- and L-6-hydroxynicotine oxidase, enantioenzymes of Arthrobacter oxidans
Z. Naturforsch. B
27
1072-1073
1972
Paenarthrobacter nicotinovorans
brenda
Dai, V.D.; Decker, K.; Sund, H.
Purification and properties of L-6-hydroxynicotine oxidase
Eur. J. Biochem.
4
95-102
1968
Paenarthrobacter nicotinovorans
brenda
Decker, K.; Dai, V.D.
Mechanism and specifcity of L- and D-6-hydroxynicotine oxidase
Eur. J. Biochem.
3
132-138
1967
Paenarthrobacter nicotinovorans
brenda
Decker, K.; Bleeg, H.
Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans
Biochim. Biophys. Acta
105
313-324
1965
Paenarthrobacter nicotinovorans
brenda
Schenk, S.; Decker, K.
Horizontal gene transfer involved in the convergent evolution of the plasmid-encoded enantioselective 6-hydroxynicotine oxidases
J. Mol. Evol.
48
178-186
1999
Paenarthrobacter nicotinovorans
brenda
Stoltz, M.; Brandsch, R.
The conformational change induced by FAD in covalently flavinylated 6-hydroxy-D-nicotine oxidase does not require (8alpha)FAD(N3)histidyl bond formation
J. Biochem.
123
445-449
1998
Paenarthrobacter nicotinovorans
brenda
Stoltz, M.; Rassow, J.; Bueckmann, A.F.; Brandsch, R.
Covalent attachment of FAD derivatives to a fusion protein consisting of 6-hydroxy-D-nicotine oxidase and a mitochondrial presequence. Folding, enzyme activity, and import of the modified protein into yeast mitochondria
J. Biol. Chem.
271
25208-25212
1996
Paenarthrobacter nicotinovorans
brenda
Stoltz, M.; Henninger, H.P.; Brandsch, R.
The design of an alternative, covalently flavinylated 6-hydroxy-D-nicotine oxidase by replacing the FAD-binding histidine by cysteine and reconstitution of the holoenzyme with 8-(methylsulfonyl)FAD
FEBS Lett.
386
194-196
1996
Paenarthrobacter nicotinovorans
brenda
Stoltz, M.; Rysavy, P.; Kalousek, F.; Brandsch, R.
Folding, flavinylation, and mitochondrial import of 6-hydroxy-D-nicotine oxidase fused to the presequence of rat dimethylglycine dehydrogenase
J. Biol. Chem.
270
8016-8022
1995
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Bichler, V.; Mauch, L.; Decker, K.
Cysteine to serine replacements in 6-hydroxy-D-nicotine oxidase. Consequences for enzyme activity, cofactor incorporation, and formation of high molecular weight protein complexes with molecular chaperones (GroEL)
J. Biol. Chem.
268
12724-12729
1993
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Bichler, V.; Schmidt, M.; Buchner, J.
GroE dependence of refolding and holoenzyme formation of 6-hydroxy-D-nicotine oxidase
J. Biol. Chem.
267
20844-20849
1992
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Bichler, V.
Autoflavinylation of apo6-hydroxy-D-nicotine oxidase
J. Biol. Chem.
266
19056-19062
1991
Paenarthrobacter nicotinovorans
brenda
Mauch, L.; Bichler, V.; Brandsch, R.
Lysine can replace arginine 67 in the mediation of covalent attachment of FAD to histidine 71 of 6-hydroxy-D-nicotine oxidase
J. Biol. Chem.
265
12761-12762
1990
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Bichler, V.; Krauss, B.
Binding of FAD to 6-hydroxy-D-nicotine oxidase apoenzyme prevents degradation of the holoenzyme
Biochem. J.
258
187-192
1989
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Bichler, V.
Covalent cofactor binding to flavoenzymes requires specific effectors
Eur. J. Biochem.
182
125-128
1989
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Faller, W.; Schneider, K.
Plasmid pAO1 of Arthrobacter oxidans encodes 6-hydroxy-D-nicotine oxidase: cloning and expression of the gene in Escherichia coli
Mol. Gen. Genet.
202
96-101
1986
Paenarthrobacter nicotinovorans
brenda
Brandsch, R.; Bichler, V.
In vivo and in vitro expression of the 6-hydroxy-D-nicotine oxidase gene of Arthrobacter oxidans, cloned into Escherichia coli, as an enzymatically active, covalently flavinylated polypeptide
FEBS Lett.
192
204-208
1985
Paenarthrobacter nicotinovorans
brenda
Decker, K.
Structure and synthesis of a flavoprotein with covalently bound FAD
Trends Biochem. Sci.
1
184-185
1976
Paenarthrobacter nicotinovorans
-
brenda
Bruhmuller, M.; Mhler, H.; Decker, K.
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase
Eur. J. Biochem.
29
143-151
1972
Paenarthrobacter nicotinovorans
brenda
Mhler, H.; Bruhmuller, M.; Decker, K.
Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Identification of the 8 -(N-3-histidyl)-riboflavin-linkage between FAD and apoenzyme
Eur. J. Biochem.
29
152-155
1972
Paenarthrobacter nicotinovorans
brenda
Koetter, J.W.; Schulz, G.E.
Crystal structure of 6-hydroxy-D-nicotine oxidase from Arthrobacter nicotinovorans
J. Mol. Biol.
352
418-428
2005
Paenarthrobacter nicotinovorans
brenda
Kachalova, G.S.; Bourenkov, G.P.; Mengesdorf, T.; Schenk, S.; Maun, H.R.; Burghammer, M.; Riekel, C.; Decker, K.; Bartunik, H.D.
Crystal structure analysis of free and substrate-bound 6-hydroxy-L-nicotine oxidase from Arthrobacter nicotinovorans
J. Mol. Biol.
396
785-799
2010
Paenarthrobacter nicotinovorans
brenda
Fitzpatrick, P.F.; Dougherty, V.; Subedi, B.; Quilantan, J.; Hinck, C.S.; Lujan, A.I.; Tormos, J.R.
Mechanism of the flavoprotein D-6-hydroxynicotine oxidase Substrate specificity, pH and solvent isotope effects, and roles of key active-site residues
Biochemistry
58
2534-2541
2019
Paenarthrobacter nicotinovorans (Q8GAG1)
brenda