Reference on EC 1.5.1.34 - 6,7-dihydropteridine reductase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rebrin, I.; Bailey, S.W.; Ayling, J.E.
Activity of the bifunctional protein 4alpha-hydroxy-tetrahydropterin dehydratase/DCOH during human fetal development: correlation with dihydropteridine reductase activity and tetrahydrobiopterin levels
Biochem. Biophys. Res. Commun.
217
958-965
1995
Homo sapiens
Kaufman, S.
Dihydropteridine reductase from sheep liver
Methods Enzymol.
142
97-103
1987
Ovis aries
Hasegawa, H.; Nakanishi, N.
Dihydropteridine reductase from bovine liver
Methods Enzymol.
142
103-110
1987
Bos taurus
Hasegawa, H.; Nakanishi, N.
NADPH-specific dihydropteridine reductase from bovine liver
Methods Enzymol.
142
111-116
1987
Bos taurus
Firgaira, F.A.; Cotton, R.G.H.; Jennings, I.; Danks, D.M.
Use of naphthoquinone adsorbent for the isolation of human dihydropteridine reductase
Methods Enzymol.
142
116-126
1987
Homo sapiens
Scrimgeour, K.G.; Cheema-Dhadli, S.
Dihydropteridine reductase from sheep brain
Methods Enzymol.
142
127-132
1987
Ovis aries
Williams, C.D.; Dickens, G.; Letendre, C.H.; Guroff, G.; Haines, C.; Shiota, T.
Isolation and characterization of dihydropteridine reductase from Pseudomonas species
J. Bacteriol.
127
1197-1207
1976
BRENDA: Pseudomonas sp.
Textmining: Pseudomonas, bacterium
Lockyer, J.; Cook, R.G.; Milstein, S.; Kaufman, S.; Woo, S.L.C.; Ledley, F.D.
Structure and expression of human dihydropteridine reductase
Proc. Natl. Acad. Sci. USA
84
3329-3333
1987
Ovis aries, Homo sapiens
Matthews, D.A.; Varughese, K.I.; Skinner, M.; Xuong, N.H.; Hoch, J.; Trach, K.; Schneider, M.; Bray, T.; Whiteley, J.M.
Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase
Arch. Biochem. Biophys.
287
234-239
1991
BRENDA: Rattus norvegicus
Textmining: Bacteria, Dialysis, Escherichia coli, Rattus
Armarego, W.L.F.; Cotton, G.H.; Dahl, H.H.M.; Dixon, N.E.
High-level expression of human dihydropteridine reductase (EC 1.6.99.7), without N-terminal amino acid protection, in Escherichia coli
Biochem. J.
261
265-268
1989
BRENDA: Homo sapiens
Textmining: Escherichia coli, Gossypium hirsutum, Escherichia virus Lambda
Shahbaz, M.; Hoch, J.A.; Trach, A.; Hural, J.A.; Webber, S.; Whiteley, J.M.
Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase
J. Biol. Chem.
262
16412-16416
1987
BRENDA: Rattus norvegicus
Textmining: Rattus, Homo sapiens
Kwan, S.W.; Shen, R.S.; Abell, C.W.
An enzyme immunoassay for the quantitation of dihydropteridine reductase
Anal. Biochem.
164
391-396
1987
BRENDA: Rattus norvegicus
Textmining: Capra hircus, Rattus
Matthews, D.A.; Webber, S.; Whiteley, J.M.
Preliminary x-ray diffraction characterization of crystalline rat liver dihydropteridine reductase
J. Biol. Chem.
261
3891-3893
1986
BRENDA: Rattus norvegicus
Textmining: Rattus
Randles, D.
Temperature dependence of dihydropteridine reductase activity
Eur. J. Biochem.
155
301-304
1986
Homo sapiens
Hasegawa, H.
Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH
J. Biochem.
81
169-177
1977
BRENDA: Bos taurus
Textmining: Ovis aries
Webber, S.; Whiteley, J.M.
Pyridine nucleotide interaction with rat liver dihydropteridine reductase
J. Biol. Chem.
253
6724-6729
1978
BRENDA: Rattus norvegicus
Textmining: Rattus, Dialysis
Purdy, S.E.; Blair, J.A.; Barford, P.A.
Inhibition of dihydropteridine reductase by dopamine
Biochem. J.
195
769-771
1981
Rattus norvegicus
Gould, K.G.; Engel, P.C.
Rat liver dihydropteridine reductase inhibition
Biochem. Soc. Trans.
8
565-566
1980
BRENDA: Rattus norvegicus
Textmining: Rattus
Firgaira, F.A.; Choo, K.H.; Cotton, R.G.H.; Danks, D.M.
Molecular and immunological comparison of human dihydropteridine reductase in liver, cultured fibroblasts and continuous lymphoid cells
Biochem. J.
197
45-53
1981
BRENDA: Homo sapiens
Textmining: Oryctolagus cuniculus
Webber, S.; Whiteley, J.M.
The effect of specific amino acid modifications on the catalytic properties of rat liver dihydropteridine reductase
Arch. Biochem. Biophys.
206
145-152
1981
BRENDA: Rattus norvegicus
Textmining: Rattus
Bailey, S.W.; Ayling, J.E.
6,6-Dimethylpterins: stable quinoid dihydropterin substrate for dihydropteridine reductase and tetrahydropterin cofactor for phenylalanine hydroxylase
Biochemistry
22
1790-1798
1983
BRENDA: Bos taurus, Ovis aries
Textmining: Rattus
Armarego, W.L.F.; Waring, P.
Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes
Biochem. Biophys. Res. Commun.
113
895-899
1983
Homo sapiens
Shen, R.S.
Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
Biochim. Biophys. Acta
785
181-185
1984
Ovis aries, Homo sapiens, Rattus norvegicus
Abell, C.W.; Shen, R.S.; Gessner, W.; Brossi, A.
Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
Science
224
405-407
1984
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Primates, Rattus
Shen, R.S.; Smith, R.V.; Davis, P.J.; Abell, C.W.
Inhibition of dihydropteridine reductase from human liver and rat striatal synaptosomes by apomorphine and its analogs
J. Biol. Chem.
259
8994-9000
1984
BRENDA: Homo sapiens, Rattus norvegicus
Textmining: Rattus
Randles, D.; Armarego, L.F.
Reduced 6,6,8-trimethylpterins. Preparation, properties and enzymic reactivities with dihydropteridine reductase, phenylalanine hydroxylase and tyrosine hydroxylase
Eur. J. Biochem.
146
467-474
1985
Ovis aries
Armarego, W.L.F.; Ohnishi, A.; Taguchi, H.
New pteridine substrates for dihydropteridine reductase and horseradish peroxidase
Biochem. J.
234
335-342
1986
BRENDA: Homo sapiens
Textmining: Armoracia rusticana
Shen, R.S.
Inhibition of dihydropteridine reductase by catecholamines and related compounds
Biochim. Biophys. Acta
743
129-135
1983
Homo sapiens
Armarego, W.L.F.; Ohnishi, A.
Inactivation of dihydropteridine reductase (human brain) by platinum(II) complexes
Eur. J. Biochem.
164
403-409
1987
Homo sapiens
Nakanishi, N.; Ozawa, K.; Yamada, S.
Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes
J. Biochem.
99
1311-1315
1986
BRENDA: Bos taurus, Homo sapiens, Macaca fascicularis
Textmining: Platyrrhini
Waring, P.
The time-dependent inactivation of human brain dihydropteridine reductase by the oxidation products of L-dopa
Eur. J. Biochem.
155
305-310
1986
Homo sapiens
Shen, R.S.; Smith, R.V.; Davis, P.J.; Brubaker, A.; Abell, C.W.
Dopamine-derived tetrahydroisoquinolines. Novel inhibitors of dihydropteridine reductase
J. Biol. Chem.
257
7294-7297
1982
BRENDA: Homo sapiens
Textmining: Mammalia
Nakanishi, N.; Hirayama, K.; Yamada, S.
A simple procedure for purification of NADH-specific dihydropteridine reductase from mammalian liver
J. Biochem.
92
1033-1040
1982
BRENDA: Bos taurus, Homo sapiens, Rattus norvegicus
Textmining: Rattus
Musacchio, J.M.
Beef adrenal medulla dihydropteridine reductase
Biochim. Biophys. Acta
191
485-487
1969
Bos taurus
Nielsen, K.H.; Simonsen, V.; Lind, K.E.
Dihydropteridine reductase. A method for the measurement of activity, and investigations of the specificity for NADH and NADPH
Eur. J. Biochem.
9
497-502
1969
Bos taurus, Oryctolagus cuniculus, Felis catus, Ovis aries, Rattus norvegicus
Hirayama, K.; Nakanisi, N.; Sueoka, T.; Katoh, S.; Yamada, S.
Dihydropteridine reductase and tetrahydropterin in Crithidia fasciculata cells
Biochim. Biophys. Acta
612
337-343
1980
Crithidia fasciculata
Firgaira, F.A.; Cotton, G.H.; Danks, D.M.
Isolation and characterization of dihydropteridine reductase from human liver
Biochem. J.
197
31-43
1981
BRENDA: Homo sapiens
Textmining: Bos taurus, Ovis aries
Nakanishi, N.; Hasegawa, H.; Watabe, S.
A new enzyme, NADPH-dihydropteridine reductase in bovine liver
J. Biochem.
81
681-685
1977
Bos taurus
Craine, J.E.; Hall, E.S.; Kaufman, S.
The isolation and characterization of dihydropteridine reductase from sheep liver
J. Biol. Chem.
247
6082-6091
1972
Ovis aries, Homo sapiens, Rattus norvegicus
Lind, K.E.
Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines
Eur. J. Biochem.
25
560-562
1972
Rattus norvegicus
Vasudevan, S.G.; Shaw, D.C.; Armarego, W.L.F.
Dihydropteridine reductase from Escherichia coli
Biochem. J.
255
581-588
1988
BRENDA: Escherichia coli
Textmining: Electron
Webber, S.; Hural, J.A.; Whiteley, J.M.
Multiple forms of rat-liver dihydropteridine reductase identified by their differing isoelectric points
Arch. Biochem. Biophys.
248
358-367
1986
Rattus norvegicus
Nakanishi, N.; Hasegawa, H.; Yamada, S.; Akino, M.
Purification and physicochemical properties of NADPH-specific dihydropteridine reductase from bovine and human livers
J. Biochem.
99
635-644
1986
Bos taurus, Homo sapiens
Nakanishi, N.; Hasegawa, H.; Akino, M.; Yamada, S.
Catalytic properties of NADPH-specific dihydropteridine reductase from bovine liver
J. Biochem.
99
645-652
1986
Bos taurus
Su, Y.; Varughese, K.I.; Xuong, N.H.; Bray, T.L.; Roche, D.J.; Whiteley, J.M.
The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue
J. Biol. Chem.
268
26836-26841
1993
BRENDA: Homo sapiens
Textmining: Escherichia coli, Rattus
Varughese, K.I.; Xuong, N.H.; Whiteley, J.M.
Structural and mechanistic implications of incorporating naturally occurring aberrant mutations of human dihydropteridine reductase into a rat model
Int. J. Pept. Protein Res.
44
278-287
1994
BRENDA: Homo sapiens
Textmining: Rattus, Escherichia coli, insertion sequences
Varughese, K.I.; Xuong, N.H.; Kiefer, P.M.; Matthews, D.A.; Whiteley, J.M.
Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases
Proc. Natl. Acad. Sci. USA
91
5582-5586
1994
Rattus norvegicus
Zhang, H.P.; Yang, N.; Armarego, W.L.F.
In vitro mutagenesis of human dihydropteridine reductase at the active site and at altered sites found in the reductases of deficient children
Pteridines
7
123-136
1996
Homo sapiens
-
Kiefer, P.M.; Varughese, K.I.; Su, Y.; Xuong, N.H.; Chang, C.F.; Gupta, P.; Bray, T.; Whiteley, J.M.
Altered structural and mechanistic properties of mutant dihydropteridine reductases
J. Biol. Chem.
271
3437-3444
1996
BRENDA: Rattus norvegicus
Textmining: Escherichia coli, Rattus
Altindag, Z.; Sahin, G.
The change in dihydropteridin reductase activity in some diseases
Pharm. Sci.
2
335-337
1996
Homo sapiens
-
Kiefer, P.M.; Grimshaw, C.E.; Whiteley, J.M.
The comparative interaction of quinonoid (6R)-Dihydrobiopterin and an alternative dihydropterin substrate with wild-type and mutant rat dihydropteridine reductases
Biochemistry
36
9438-9445
1997
BRENDA: Rattus norvegicus
Textmining: Rattus
Chang, C.F.; Bray, T.; Varughese, K.I.; Whiteley, J.M.
Comparative properties of three pteridine reductases
Adv. Exp. Med. Biol.
463
403-410
1999
Rattus norvegicus
Park, D.; Park, S.; Yim, J.
Molecular characterization of Drosophila melanogaster dihydropteridine reductase
Biochim. Biophys. Acta
1492
247-251
2000
BRENDA: Drosophila melanogaster
Textmining: Drosophila, Escherichia coli, Homo sapiens, Mus musculus
Schallreuter, K.U.; Elwary, S.M.A.; Gibbons, N.C.J.; Rokos, H.; Wood, J.M.
Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo
Biochem. Biophys. Res. Commun.
315
502-508
2004
Homo sapiens
Wild, C.; Golderer, G.; Grobner, P.; Werner-Felmayer, G.; Werner, E.R.
Physarum polycephalum expresses a dihydropteridine reductase with selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution
Biol. Chem.
384
1057-1062
2003
BRENDA: Physarum polycephalum (Q8WTJ2), Physarum polycephalum
Textmining: Physarum, Homo sapiens, Ovis aries, animal
Wilquet, V.; Van de Casteele, M.; Gigot, D.; Legrain, C.; Glansdorff, N.
Dihydropteridine reductase as an alternative to dihydrofolate reductase for synthesis of tetrahydrofolate in Thermus thermophilus
J. Bacteriol.
186
351-355
2004
BRENDA: Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Textmining: Escherichia coli, Bacteria, Archaea, bacterium
Hasse, S.; Gibbons, N.C.; Rokos, H.; Marles, L.K.; Schallreuter, K.U.
Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress
J. Invest. Dermatol.
122
307-313
2004
Homo sapiens (P09417), Homo sapiens
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
Schormann, N.; Pal, B.; Senkovich, O.; Carson, M.; Howard, A.; Smith, C.; Delucas, L.; Chattopadhyay, D.
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor
J. Struct. Biol.
152
64-75
2005
Trypanosoma cruzi
Perez-Reinado, E.; Roldan, M.D.; Castillo, F.; Moreno-Vivian, C.
The NprA nitroreductase required for 2,4-dinitrophenol reduction in Rhodobacter capsulatus is a dihydropteridine reductase
Environ. Microbiol.
10
3174-3183
2008
BRENDA: Rhodobacter capsulatus
Textmining: Escherichia coli, Electron
Concolino, D.; Muzzi, G.; Rapsomaniki, M.; Moricca, M.T.; Pascale, M.G.; Strisciuglio, P.
Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients
J. Inherit. Metab. Dis.
Suppl. 2
193-197
2008
Homo sapiens
Chen, C.; Seo, K.H.; Kim, H.L.; Zhuang, N.; Park, Y.S.; Lee, K.H.
Crystallization and preliminary characterization of dihydropteridine reductase from Dictyostelium discoideum
Acta Crystallogr. Sect. F
64
1013-1015
2008
Dictyostelium discoideum
Lee, C.K.; Han, J.S.; Won, K.J.; Jung, S.H.; Park, H.J.; Lee, H.M.; Kim, J.; Park, Y.S.; Kim, H.J.; Park, P.J.; Park, T.K.; Kim, B.
Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels
Proteomics
9
4851-4858
2009
BRENDA: Rattus norvegicus
Textmining: Rattus
Manjarrez-Gutierrez, G.; Gonzalez-Ramirez, M.; Boyzo-Montes de Oca, A.; Hernandez-Rodriguez, J.
Dihydropteridine reductase activity in the brainstem of intrauterine growth-restricted rats
Int. J. Dev. Neurosci.
28
621-624
2010
BRENDA: Rattus norvegicus
Textmining: Rattus
Gu, Y.; Gong, Y.; Zhang, H.; Dong, X.; Zhao, T.; Burczynski, F.J.; Wang, G.; Sun, S.; Zhu, B.; Han, W.; Wang, H.; Li, P.
Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells
Biochem. Cell Biol.
91
187-193
2013
BRENDA: Rattus norvegicus
Textmining: Homo sapiens, Rattus
Chen, C.; Kim, H.L.; Zhuang, N.; Seo, K.H.; Park, K.H.; Han, C.D.; Park, Y.S.; Lee, K.H.
Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin
FEBS Lett.
585
2640-2646
2011
BRENDA: Dictyostelium discoideum (Q86A17), Dictyostelium discoideum
Textmining: Dictyostelium, Mammalia, Rattus
Ong, H.B.; Sienkiewicz, N.; Wyllie, S.; Fairlamb, A.H.
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major
J. Biol. Chem.
286
10429-10438
2011
Leishmania, Leishmania major, Trypanosoma brucei, Rattus
Hara, R.; Kino, K.
Enhanced synthesis of 5-hydroxy-L-tryptophan through tetrahydropterin regeneration
AMB Express
3
70
2013
Bacillus subtilis, Escherichia coli, Pseudomonas syringae, Pseudomonas syringae (Q48G05)
Schmidt, K.; Kolesnik, B.; Gorren, A.; Werner, E.; Mayer, B.
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling
Biochem. Pharmacol.
90
246-253
2014
Homo sapiens (P09417), Sus scrofa (Q8MJ30)
Li, W.; Gong, M.; Shu, R.; Li, X.; Gao, J.; Meng, Y.
Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori
Comp. Biochem. Physiol. B
186
20-27
2015
BRENDA: Bombyx mori
Textmining: Citrus limon, Hexapoda, Mammalia
Xu, Y.; Li, Y.; Li, L.; Zhang, L.; Ding, Z.; Shi, G.
Reductase-catalyzed tetrahydrobiopterin regeneration alleviates the anti-competitive inhibition of tyrosine hydroxylation by 7,8-dihydrobiopterin
Catal. Sci. Technol.
11
3128-3140
2021
Escherichia coli (P38489)
-
Shen, RS; Zhang, YX; Perez-Polo, JR
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
J Enzyme Inhib
3
119-26
1989
Rattus
Rao, GN; Cotlier, E
The enzymatic activities of GTP cyclohydrolase, sepiapterin reductase, dihydropteridine reductase and dihydrofolate reductase; and tetrahydrobiopterin content in mammalian ocular tissues and in human senile cataracts.
Comp Biochem Physiol B
80
61-6
1985
Homo sapiens, Oryctolagus cuniculus, Rattus
Zhu, H; Riggs, AF
Yeast flavohemoglobin is an ancient protein related to globins and a reductase family.
Proc Natl Acad Sci U S A
89
5015-9
1992
Bacteria, Vitreoscilla sp., Sinorhizobium meliloti, bacterium
Chenevert, SW; Fossett, NG; Chang, SH; Tsigelny, I; Baker, ME; Lee, WR
Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase.
Biochem J
308 ( Pt 2)
419-23
1995
Rattus
Tsigelny, I; Baker, ME
Structures stabilizing the dimer interface on human 11 beta-hydroxysteroid dehydrogenase types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase and their homologs.
Biochem Biophys Res Commun
217
859-68
1995
Homo sapiens, Rattus, Streptomyces hydrogenans
Vasudevan, SG; Paal, B; Armarego, WL
Dihydropteridine reductase from Escherichia coli exhibits dihydrofolate reductase activity.
Biol Chem Hoppe Seyler
373
1067-73
1992
Escherichia coli, Electron
Komori, Y; Hyun, J; Chiang, K; Fukuto, JM
The role of thiols in the apparent activation of rat brain nitric oxide synthase (NOS).
J Biochem (Tokyo)
117
923-7
1995
Rattus
Algeri, S; Bonati, M; Brunello, N; Ponzio, F
Dihydropteridine reductase and tyrosine hydroxylase activities in rat brain during development and senescence: a comparative study.
Brain Res
132
569-74
1977
Rattus
Mullen, BJ; Wang, M
Activities of cerebral dihydropteridine reductase and tyrosine hydroxylase in chronic uremia in rats.
J Nutr
116
1298-305
1986
Rattus, Metazoa
Charpentier, C; Domange, C; Wolf, M; Barthon, F; Laggoune, B; Lemonnier, A
[Comparative effects of different inhibitors of phenylalanine hydroxylase and dihydropteridine reductase. In vivo and in vitro study in rats]
Arch Fr Pediatr
35
93-101
1978
Rattus
Katoh, S; Sueoka, T
Pteridine cofactor of phenylalanine hydroxylase in fetal rat liver.
Int J Biochem
15
57-64
1983
Rattus
Lin, CM; Tan, Y; Lee, YM; Chang, CC; Hsiao, KJ
Expression of human phenylalanine hydroxylase activity in T lymphocytes of classical phenylketonuria children by retroviral-mediated gene transfer.
J Inherit Metab Dis
20
742-54
1997
Homo sapiens
Yang, L; Zhang, ZX; Ye, J; Zhou, ZS; Shen, M; Han, LS; Qiu, W; Yu, WM; Gu, XF
[Clinical study of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency in southern and northern Chinese patients]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
24
310-3
2007
Homo sapiens
Milstien, S; Kaufman, S
The oxidation of apomorphine and other catechol compounds by horseradish peroxidase: relevance to the measurement of dihydropteridine reductase activity.
Biochim Biophys Acta
923
333-8
1987
Armoracia rusticana
Werner, ER; Pitters, E; Schmidt, K; Wachter, H; Werner-Felmayer, G; Mayer, B
Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase.
Biochem J
320 ( Pt 1)
193-6
1996
Rattus
Firgaira, FA; Cotton, RG; Danks, DM
Human dihydropteridine reductase: a method for the measurement of activity in cultured cells, and its application to malignant hyperphenylalaninemia.
Clin Chim Acta
95
47-59
1979
Homo sapiens
Aksnes, A; Skotland, T; Flatmark, T; Ljones, T
Bovine dihydropteridine reductase: purification by affinity chromatography and comparison of enzymes from liver and adrenal medulla.
Neurochem Res
4
385-98
1979
Bos taurus
Armarego, WL
Hydrogen transfer from 4-R and 4-S (4-3H) NADH in the reduction of d,l-cis-6,7-dimethyl-6,7 (8H) dihydropterin with dihydropteridine reductase from human liver and sheep liver.
Biochem Biophys Res Commun
89
246-9
1979
Homo sapiens, Ovis aries
Nakanishi, N; Hirayama, K; Sueoka, T; Katoh, S; Yamada, S
[Dihydropteridine reductase and tetrahydropterin in Crithidia fasciculata cells (author's transl)]
Josai Shika Daigaku Kiyo
8
15-21
1979
Crithidia fasciculata
Cotton, RG; Jennings, I
A naphthoquinone adsorbent for affinity chromatography of human dihydropteridine reductase.
Eur J Biochem
83
319-24
1978
Homo sapiens
Abelson, HT; Gorka, C; Beardsley, GP
Identification of dihydropteridine reductase in human platelets.
Blood
53
116-21
1979
Homo sapiens
Milstien, S; Kaufman, S
Production of antibodies to sheep liver dihydropteridine reductase: characterization and use to study the enzyme defect in a variant form of phenylketonuria.
Biochem Biophys Res Commun
66
475-81
1975
Ovis aries
Milstien, S; Holtzman, NA; O'Flynn, ME; Thomas, GH; Butler, IJ; Kaufman, S
Hyperphenylalaninemia due to dihydropteridine reductase deficiency. Assay of the enzyme in fibroblasts from affected infants, heterozygotes, and in normal amniotic fluid cells.
J Pediatr
89
763-6
1976
Homo sapiens
Varughese, KI; Skinner, MM; Whiteley, JM; Matthews, DA; Xuong, NH
Crystal structure of rat liver dihydropteridine reductase.
Proc Natl Acad Sci U S A
89
6080-4
1992
Rattus, insertion sequences, Homo sapiens
Bolla, KI; Milstien, S; Briefel, G; Wieler, L; Kaufman, S
Dihydropteridine reductase activity: lack of association with serum aluminum levels and cognitive functioning in patients with end-stage renal disease.
Neurology
41
1806-9
1991
Homo sapiens, Dialysis
Howells, DW; Forrest, SM; Dahl, HH; Cotton, RG
Insertion of an extra codon for threonine is a cause of dihydropteridine reductase deficiency.
Am J Hum Genet
47
279-85
1990
Homo sapiens, insertion sequences
Woody, RC; Brewster, MA
Adverse effects of trimethoprim-sulfamethoxazole in a child with dihydropteridine reductase deficiency.
Dev Med Child Neurol
32
639-42
1990
Homo sapiens
Blau, N; Curtius, AC; Kierat, L; Leupold, D; Kohne, E
Hyperphenylalaninemia caused by dihydropteridine reductase deficiency in children receiving chemotherapy for acute lymphoblastic leukemia.
J Pediatr
115
661-3
1989
Homo sapiens
Dahl, HH; Hutchison, W; McAdam, W; Wake, S; Morgan, FJ; Cotton, RG
Human dihydropteridine reductase: characterisation of a cDNA clone and its use in analysis of patients with dihydropteridine reductase deficiency.
Nucleic Acids Res
15
1921-32
1987
Homo sapiens
Webber, S; Hural, JA; Whiteley, JM
The estimation of dihydropteridine reductase in human blood cells.
Clin Chim Acta
173
117-26
1988
Homo sapiens, Rattus, Canis lupus familiaris, Sus scrofa, Bos taurus, Oryctolagus cuniculus
Webber, S; Baumgartner, K; Blair, JN; Whiteley, JM
Interaction of a photolabile NADH analog with rat liver dihydropteridine reductase.
Biochem Pharmacol
37
2869-72
1988
Rattus
Cutler, P; Blair, JA
The effect of lead and aluminium on rat dihydropteridine reductase.
Arch Toxicol Suppl
11
227-30
1987
Rattus
Bradbury, AJ; Brossi, A; Costall, B; Domeney, AM; Gessner, W; Naylor, RJ
Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase.
Neuropharmacology
25
583-6
1986
Rattus
Shen, RS; Abell, CW
Rat striatal synaptosomes as a model system for studying the inhibition of dihydropteridine reductase activity.
J Enzyme Inhib
1
223-9
1987
Rattus, Homo sapiens
Webber, S; Hural, J; Whiteley, JM
Preliminary studies on the primary structure of rat liver dihydropteridine reductase.
Biochem Biophys Res Commun
143
582-6
1987
Rattus
Altmann, P; Al-Salihi, F; Butter, K; Cutler, P; Blair, J; Leeming, R; Cunningham, J; Marsh, F
Serum aluminum levels and erythrocyte dihydropteridine reductase activity in patients on hemodialysis.
N Engl J Med
317
80-4
1987
Homo sapiens, Dialysis
Brown, RM; Dahl, HH
Localization of the human dihydropteridine reductase gene to band p15.3 of chromosome 4 by in situ hybridization.
Genomics
1
67-70
1987
Homo sapiens
Aluminum and dihydropteridine reductase in dialysis patients.
N Engl J Med
317
1604-6
1987
Homo sapiens, Dialysis
Nakanishi, N; Yoshida, A; Ozawa, K; Yamada, S
Purification and properties of NADH-specific dihydropteridine reductase from human erythrocytes.
Enzyme
35
42-52
1986
Bos taurus, Homo sapiens
Szymanski, HV; Orfanos, A; Narisawa, K; Grosz, R; Naylor, EW
Dihydropteridine reductase in schizophrenic patients.
Psychiatry Res
15
115-9
1985
Homo sapiens
Shen, RS
Inhibition of dihydropteridine reductase in rat striatal synaptosomes and from human liver by metabolites of biogenic amines.
J Enzyme Inhib
1
61-6
1985
Homo sapiens, Rattus
Gromov, PS; Bakharev, VA; Annenkov, GA
[Active form of dihydropteridine reductase in human chorion cells. Possibility of prenatal diagnosis]
Vopr Med Khim
31
73-5
0
Homo sapiens
Turner, AJ; Ponzio, F; Algeri, S
Dihydropteridine reductase in rat brain: regional distribution and the effect of catecholamine-depleting drugs.
Brain Res
70
553-8
1974
Rattus
Poddar, S; Henkin, J
Isotope, pulse-chase, stopped-flow, and rapid quench studies on the kinetic mechanism of bovine dihydropteridine reductase.
Biochemistry
23
3143-8
1984
Bos taurus
Nakanisi, N; Ozawa, K; Yamada, S; Irie, E; Osaka, N; Goto, H
[NADPH-specific dihydropteridine reductase from Macaca fascicularis liver. I. Purification and properties]
Josai Shika Daigaku Kiyo
12
22-7
1983
Macaca fascicularis
Nakanisi, N; Ozawa, K; Yamada, S; Irie, E; Osaka, N; Goto, H
[Studies on NADPH-specific dihydropteridine reductase from Macaca fascicularis liver. II. Effect of inhibitors]
Josai Shika Daigaku Kiyo
12
179-84
1983
Macaca fascicularis
Gromov, PS; Val'iano, NM; Akhunov, VS; Annenkov, GA
[Dihydropteridine reductase activity in leukocytes and cultured fibroblasts of health individuals and of patients with the classical form of phenylketonuria]
Vopr Med Khim
29
66-9
0
Homo sapiens
Hirayama, ST; Nakanishi, N; Katoh, S; Tachiawa, A; Yamada, S
[Partial purification of dihydropteridine reductase from rat erythrocytes (author's transl)]
Josai Shika Daigaku Kiyo
1
11-5
1980
Rattus
Nakanisi, N; Hirayama, K; Sueoka, T; Masuda, I; Katoh, S; Yamada, S
[Catalytic properties of dihydropteridine reductase from Crithidia fasciculata (author's transl)]
Josai Shika Daigaku Kiyo
1
7-10
1980
Crithidia fasciculata
Shen, R; Abell, CW
Purification of dihydropteridine reductase from human platelets.
J Neurosci Res
6
193-201
1981
Homo sapiens
Firgaira, FA; Choo, KH; Cotton, RG; Danks, DM
Heterogeneity of the molecular defect in human dihydropteridine reductase deficiency.
Biochem J
198
677-82
1981
Homo sapiens
Milstien, S; Kaufman, S
Preparation of an antiserum to sheep liver dihydropteridine reductase.
Methods Enzymol
66
723-5
1980
Ovis aries
Kuhl, P; Olek, K; Wardenbach, P
Dihydropteridine reductase variation in man and the characid fish "Cheirodon axelrodi": evidence for a dimeric enzyme structure.
Hum Genet
55
99-102
1980
Chondrichthyes, Homo sapiens
Hyland, K; Heales, SJ
Tetrahydrobiopterin and quinonoid dihydrobiopterin concentrations in CSF from patients with dihydropteridine reductase deficiency.
J Inherit Metab Dis
16
608-10
1993
Homo sapiens
Varughese, KI; Su, Y; Skinner, MM; Xuong, NH; Matthews, DA; Whiteley, JM
Two crystal structures of rat liver dihydropteridine reductase.
Adv Exp Med Biol
338
123-6
1993
Rattus
Dianzani, I; Howells, DW; Ponzone, A; Saleeba, JA; Smooker, PM; Cotton, RG
Two new mutations in the dihydropteridine reductase gene in patients with tetrahydrobiopterin deficiency.
J Med Genet
30
465-9
1993
Homo sapiens, animal
Ikeda, H; Matsubara, Y; Mikami, H; Kure, S; Owada, M; Gough, T; Smooker, PM; Dobbs, M; Dahl, HH; Cotton, RG; Narisawa, K
Molecular analysis of dihydropteridine reductase deficiency: identification of two novel mutations in Japanese patients.
Hum Genet
100
637-42
1997
Homo sapiens, insertion sequences
Larnaout, A; Belal, S; Miladi, N; Kaabachi, N; Mebazza, A; Dhondt, JL; Hentati, F
Juvenile form of dihydropteridine reductase deficiency in 2 Tunisian patients.
Neuropediatrics
29
322-3
1998
Homo sapiens
Mikaeloff, Y; Plouin, P; Dhondt, JL; Ponsot, G; Dulac, O
Clinical and EEG video-polygraphic features of epileptic spasms in a child with dihydropteridine reductase deficiency. Efficiency of hydrocortisone.
Epileptic Disord
2
213-7
2000
Homo sapiens
Symersky, J; Li, S; Carson, M; Luo, D; Luan, CH; Luo, M
Structural genomics of Caenorhabditis elegans: structure of dihydropteridine reductase.
Proteins
53
944-6
2003
Caenorhabditis elegans
Ponzone, A; Spada, M; Ferraris, S; Dianzani, I; de Sanctis, L
Dihydropteridine reductase deficiency in man: from biology to treatment.
Med Res Rev
24
127-50
2004
Homo sapiens
Su, Y; Skinner, MM; Xuong, NH; Matthews, DA; Whiteley, JM; Varughese, KI
Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr D Biol Crystallogr
50
884-8
1994
Rattus
Lu, DY; Ye, J; Han, LS; Qiu, WJ; Zhang, HW; Zhou, JD; Bao, PZ; Zhang, YF; Gu, XF
QDPR gene mutation and clinical follow-up in Chinese patients with dihydropteridine reductase deficiency.
World J Pediatr
10
219-26
2014
Homo sapiens
Linwu, SW; Syu, CJ; Chen, YL; Wang, AH; Peng, FC
Characterization of Escherichia coli nitroreductase NfsB in the metabolism of nitrobenzodiazepines.
Biochem Pharmacol
78
96-103
2009
Escherichia coli, Enterobacter cloacae, Rattus, Homo sapiens
Misal, SA; Bajoria, VD; Lingojwar, DP; Gawai, KR
Purification and characterization of nitroreductase from red alkaliphilic bacterium Aquiflexum sp. DL6.
Prikl Biokhim Mikrobiol
49
249-54
0
Aquiflexum, bacterium, Homo sapiens
Kuseyri Hbschmann, O; Mohr, A; Friedman, J; Manti, F; Horvath, G; Corts-Saladelafont, E; Mercimek-Andrews, S; Yildiz, Y; Pons, R; Kulhnek, J; Oppeben, M; Koht, JA; Podzamczer-Valls, I; Domingo-Jimenez, R; Ibez, S; Alcoverro-Fortuny, O; Gmez-Alemany, T; de Castro, P; Alfonsi, C; Zafeiriou, DI; Lpez-Laso, E; Guder, P; Santer, R; Honzk, T; Hoffmann, GF; Garbade, SF; Sivri, HS; Leuzzi, V; Jeltsch, K; Garca-Cazorla, A; Opladen, T; , ; Harting, I
Brain MR patterns in inherited disorders of monoamine neurotransmitters: An analysis of 70 patients.
J Inherit Metab Dis
44
1070-1082
2021
Homo sapiens
Batllori, M; Molero-Luis, M; Arrabal, L; Heras, JL; Fernandez-Ramos, JA; Gutirrez-Solana, LG; Ibez-Mic, S; Domingo, R; Campistol, J; Ormazabal, A; Sedel, F; Opladen, T; Zouvelou, B; Pons, R; Garcia-Cazorla, A; Lopez-Laso, E; Artuch, R
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Sci Rep
7
14675
2017
Homo sapiens
Mandic, S; Volkoff, H
The effects of fasting and appetite regulators on catecholamine and serotonin synthesis pathways in goldfish (Carassius auratus).
Comp Biochem Physiol A Mol Integr Physiol
223
1-9
2018
Carassius auratus, Chondrichthyes
Cordeiro, D; Bullivant, G; Cohn, RD; Raiman, J; Mercimek-Andrews, S
Outcome of Patients With Inherited Neurotransmitter Disorders.
Can J Neurol Sci
45
571-576
2018
Homo sapiens
Opladen, T; Hoffmann, GF; Blau, N
An international survey of patients with tetrahydrobiopterin deficiencies presenting with hyperphenylalaninaemia.
J Inherit Metab Dis
2012
Homo sapiens
Khatami, S; Dehnabeh, SR; Zeinali, S; Thny, B; Alaei, M; Salehpour, S; Setoodeh, A; Rohani, F; Hajivalizadeh, F; Samavat, A
Four Years of Diagnostic Challenges with Tetrahydrobiopterin Deficiencies in Iranian Patients.
JIMD Rep
2016
Homo sapiens
Dhondt, JL; Farriaux, JP; Largilliere, C; Dautrevaux, M; Ardouin, P
Pterin metabolism in normal subjects and hyperphenylalaninaemic patients.
J Inherit Metab Dis
4
47-8
1981
Homo sapiens
Ye, J; Liu, XQ; Qiu, WJ; Han, LS; Zhou, JD; Zhang, YF; Gu, XF
[Screening for tetrahydrobiopterin metabolic disorders and related gene analysis among the patients with motor disturbance and mental retardation]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
24
210-2
2007
Homo sapiens
Khani, S; Barzegari, M; Esmaeilizadeh, Z; Farsian, P; Alaei, M; Salehpour, S; Setoodeh, A; Rohani, F; Samavat, A; Zekri, A; Mirzazadeh, R; Sadeghi, S; Khatami, S
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
J Pediatr Endocrinol Metab
34
1157-1167
2021
Homo sapiens
Andrews, SC; Shipley, D; Keen, JN; Findlay, JB; Harrison, PM; Guest, JR
The haemoglobin-like protein (HMP) of Escherichia coli has ferrisiderophore reductase activity and its C-terminal domain shares homology with ferredoxin NADP+ reductases.
FEBS Lett
302
247-52
1992
Escherichia coli
Eschenbrenner, M; Coves, J; Fontecave, M
Ferric reductases in Escherichia coli: the contribution of the haemoglobin-like protein.
Biochem Biophys Res Commun
198
127-31
1994
Escherichia coli
Zorzi, G; Thöny, B; Blau, N
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency.
J Neurochem
80
362-4
2002
Homo sapiens
Kim, HL; Park, MB; Park, YS
Tetrahydrobiopterin is functionally distinguishable from tetrahydrodictyopterin in Dictyostelium discoideum Ax2.
FEBS Lett
2011
Dictyostelium, Dictyostelium discoideum AX2
Schallreuter, KU; Büttner, G; Pittelkow, MR; Wood, JM; Swanson, NN; Körner, C
Cytotoxicity of 6-biopterin to human melanocytes.
Biochem Biophys Res Commun
204
43-8
1994
Homo sapiens
McIntosh, MJ; Meredith, PA; Moore, MR; Goldberg, A
Neurotoxic action of lead: effect on tetrahydrobiopterin metabolism in the rat.
Comp Biochem Physiol C
81
227-31
1985
Rattus
Martínez-Fong, D; Gutiérrez, ME; Aceves, J
Effect of chronic lead exposure on biopterin metabolism in the rat neostriatum.
J Neurosci Res
26
112-4
1990
Rattus
Vrecko, K; Storga, D; Birkmayer, JG; Möller, R; Tafeit, E; Horejsi, R; Reibnegger, G
NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaeochromocytoma cells.
Biochim Biophys Acta
1361
59-65
1997
Rattus, Homo sapiens
Vasudevan, SG; Armarego, WL; Shaw, DC; Lilley, PE; Dixon, NE; Poole, RK
Isolation and nucleotide sequence of the hmp gene that encodes a haemoglobin-like protein in Escherichia coli K-12.
Mol Gen Genet
226
49-58
1991
Escherichia coli, Escherichia coli K-12, Vitreoscilla
Ishikawa, T; Sumi, S; Fujimoto, S; Shima, Y; Wada, Y
Interstitial deletion of the short arm of chromosome 4 in a boy with mild psychomotor retardation and dysmorphism.
Clin Genet
38
314-7
1990
Homo sapiens
Altmann, P; Dhanesha, U; Hamon, C; Cunningham, J; Blair, J; Marsh, F
Disturbance of cerebral function by aluminium in haemodialysis patients without overt aluminium toxicity.
Lancet
2
7-12
1989
Homo sapiens, Dialysis
Hamon, CG; Cutler, P; Blair, JA
Tetrahydrobiopterin metabolism in the streptozotocin induced diabetic state in rats.
Clin Chim Acta
181
249-53
1989
Rattus
Leeming, RJ; Barford, PA; Blair, JA; Smith, I
Blood spots on Guthrie cards can be used for inherited tetrahydrobiopterin deficiency screening in hyperphenylalaninaemic infants.
Arch Dis Child
59
58-61
1984
Homo sapiens
Barford, PA; Blair, JA; Eggar, C; Hamon, C; Morar, C; Whitburn, SB
Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.
J Neurol Neurosurg Psychiatry
47
736-8
1984
Homo sapiens
Millot, F; Dhondt, JL; Mazingue, F; Mechinaud, F; Ingrand, P; Guilhot, F
Changes of cerebral biopterin and biogenic amine metabolism in leukemic children receiving 5 g/m2 intravenous methotrexate.
Pediatr Res
37
151-4
1995
Homo sapiens
Nivinskas, H; Koder, RL; Anusevicius, Z; Sarlauskas, J; Miller, AF; Cenas, N
Quantitative structure-activity relationships in two-electron reduction of nitroaromatic compounds by Enterobacter cloacae NAD(P)H:nitroreductase.
Arch Biochem Biophys
385
170-8
2001
Enterobacter cloacae
Nivinskas, H; Staskeviciene, S; Sarlauskas, J; Koder, RL; Miller, AF; Cenas, N
Two-electron reduction of quinones by Enterobacter cloacae NAD(P)H:nitroreductase: quantitative structure-activity relationships.
Arch Biochem Biophys
403
249-58
2002
Enterobacter cloacae, Electron
Zhang, ZX; Ye, J; Qiu, WJ; Han, LS; Gu, XF
[Tetrahydrobiopterin loading test in differential diagnosis among hyperphenylalaninemia patients]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
22
438-40
2005
Homo sapiens
Jäggi, L; Zurflüh, MR; Schuler, A; Ponzone, A; Porta, F; Fiori, L; Giovannini, M; Santer, R; Hoffmann, GF; Ibel, H; Wendel, U; Ballhausen, D; Baumgartner, MR; Blau, N
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Mol Genet Metab
93
295-305
2008
Homo sapiens, Indicator
Shintaku, H; Ohwada, M
Long-term follow-up of tetrahydrobiopterin therapy in patients with tetrahydrobiopterin deficiency in Japan.
Brain Dev
2012
Homo sapiens
Liu, N; Zhao, DH; Li, XL; Cui, LX; Wu, QH; Jiang, M; Kong, XD
[PTPS gene analysis and prenatal diagnosis in patients with 6-pyruvoyl-tetra hydropterin synthase deficiency].
Zhonghua Fu Chan Ke Za Zhi
51
890-894
2016
Homo sapiens
Igarashi, K; Kurata, D
Effect of High-Oleic Peanut Intake on Aging and Its Hippocampal Markers in Senescence-Accelerated Mice (SAMP8).
Nutrients
12
2020
Arachis hypogaea
Werner, ER; Habisch, HJ; Gorren, AC; Schmidt, K; Canevari, L; Werner-Felmayer, G; Mayer, B
Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase.
Biochem J
348 Pt 3
579-83
2000
Rattus
Togari, A; Kano, H; Oka, K; Nagatsu, T
Simultaneous simple purification of tyrosine hydroxylase and dihydropteridine reductase.
Anal Biochem
132
183-9
1983
Rattus
Milstien, S; Kaufman, S
Studies on the phenylalanine hydroxylase system in liver slices.
J Biol Chem
250
4777-81
1975
animal
Bartholomé, K; Byrd, DJ; Kaufman, S; Milstien, S
Atypical phenylketonuria with normal phenylalanine hydroxylase and dihydropteridine reductase activity in vitro.
Pediatrics
59
757-61
1977
Homo sapiens
Kure, S; Hou, DC; Ohura, T; Iwamoto, H; Suzuki, S; Sugiyama, N; Sakamoto, O; Fujii, K; Matsubara, Y; Narisawa, K
Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency.
J Pediatr
135
375-8
1999
Homo sapiens
Spaapen, LJ; Bakker, JA; Velter, C; Loots, W; Rubio-Gozalbo, ME; Forget, PP; Dorland, L; De Koning, TJ; Poll-The, BT; Ploos van Amstel, HK; Bekhof, J; Blau, N; Duran, M; Rubio-Gonzalbo, ME
Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates.
J Inherit Metab Dis
24
352-8
2001
Homo sapiens
Butler, IJ; Koslow, SH; Krumholz, A; Holtzman, NA; Kaufman, S
A disorder of biogenic amines in dihydropteridine reductase deficiency.
Ann Neurol
3
224-30
1978
Homo sapiens
Firgaira, FA; Cotton, RG; Danks, DM
Dihydropteridine reductase deficiency diagnosis by assays on peripheral blood-cells.
Lancet
2
1260-3
1979
Homo sapiens
Brewster, TG; Moskowitz, MA; Kaufman, S; Breslow, JL; Milstien, S; Abroms, IF
Dihydropteridine reductase deficiency associated with severe neurologic disease and mild hyperphenylalaninemia.
Pediatrics
63
94-9
1979
Homo sapiens
Sanchez-Urretia, L; Pierce, CE; Greengard, O
Dihydropteridine reductase activity of adult, fetal and neoplastic tissues.
Enzyme
23
346-52
1978
Homo sapiens, Rattus
Kaufman, S; Holtzman, NA; Milstien, S; Butler, LJ; Krumholz, A
Phenylketonuria due to a deficiency of dihydropteridine reductase.
N Engl J Med
293
785-90
1975
Homo sapiens
Blau, N; Heizmann, CW; Sperl, W; Korenke, GC; Hoffmann, GF; Smooker, PM; Cotton, RG
Atypical (mild) forms of dihydropteridine reductase deficiency: neurochemical evaluation and mutation detection.
Pediatr Res
32
726-30
1992
Homo sapiens
Grimshaw, CE; Matthews, DA; Varughese, KI; Skinner, M; Xuong, NH; Bray, T; Hoch, J; Whiteley, JM
Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement.
J Biol Chem
267
15334-9
1992
Escherichia coli, Rattus
Lipson, AH; Earl, JW; Wilcken, B; Yu, JS; O'Halloran, M; Cotton, RG
Successful treatment of dihydropteridine reductase deficiency, with an interesting effect of 5-hydroxytryptophan deficiency on sleep patterns.
J Inherit Metab Dis
14
49-52
1991
insertion sequences, Homo sapiens
Hayasaka, K; Narisawa, K; Ohura, T; Ogawa, E; Dahl, HH
Restriction fragment length polymorphisms among Japanese detected with a dihydropteridine reductase cDNA gene probe.
J Inherit Metab Dis
13
873-8
1990
Homo sapiens
Ratnam, S; Ratnam, M; Cotton, RG; Jennings, IG; Freisheim, JH
Anti-idiotypic antibodies elicited by pterin recognize active site epitopes in dihydrofolate reductases and dihydropteridine reductase.
Arch Biochem Biophys
275
344-53
1989
Homo sapiens, Escherichia coli, Glycine max
Babbar, R; Gupta, JK; Gupta, SP
Quantitative structure-activity relationship study on some dihydropteridine reductase inhibitors.
J Enzyme Inhib
2
231-7
1989
Electron
Woody, RC; Brewster, MA; Glasier, C
Progressive intracranial calcification in dihydropteridine reductase deficiency prior to folinic acid therapy.
Neurology
39
673-5
1989
Homo sapiens
Irons, M; Levy, HL; O'Flynn, ME; Stack, CV; Langlais, PJ; Butler, IJ; Milstien, S; Kaufman, S
Folinic acid therapy in treatment of dihydropteridine reductase deficiency.
J Pediatr
110
61-7
1987
Homo sapiens
MacDonald, ME; Anderson, MA; Lockyer, JL; Milstien, S; Hobbs, WJ; Faryniarz, AG; Kaufman, S; Ledley, FD; Woo, SL; Gusella, JF
Physical and genetic localization of quinonoid dihydropteridine reductase gene (QDPR) on short arm of chromosome 4.
Somat Cell Mol Genet
13
569-74
1987
Homo sapiens
Ponzone, A; Guardamagna, O; Ferraris, S; Bracco, G; Niederwieser, A; Cotton, RG
Two mutations of dihydropteridine reductase deficiency.
Arch Dis Child
63
154-7
1988
Homo sapiens
Dahl, HH; Wake, S; Cotton, RG; Danks, DM
The use of restriction fragment length polymorphisms in prenatal diagnosis of dihydropteridine reductase deficiency.
J Med Genet
25
25-8
1988
Homo sapiens
Cotton, RG; Jennings, I; Bracco, G; Ponzone, A; Guardamagna, O
Tetrahydrobiopterin non-responsiveness in dihydropteridine reductase deficiency is associated with the presence of mutant protein.
J Inherit Metab Dis
9
239-43
1986
Homo sapiens
Schmidt, H; Ullrich, K; Korinthenberg, R; Peters, PE
Basal ganglion calcification in hyperphenylalaninemia due to deficiency of dihydropteridine reductase.
Pediatr Radiol
19
54-6
1988
Homo sapiens
Gessner, W; Brossi, A; Shen, R; Abell, CW
Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
J Med Chem
28
311-7
1985
Homo sapiens, Rattus, Primates
Jeeps, CM; Silcox, A; Lloyd, B; Clayton, BE
Dihydropteridine reductase activity in dried blood spots: effects of aging and senile dementia of the Alzheimer type.
J Clin Pathol
39
199-203
1986
Homo sapiens
Shen, RS; Sheng, WL; Abell, CW
Effects of nomifensine and its metabolites on dihydropteridine reductase.
J Pharm Pharmacol
36
411-3
1984
Homo sapiens, Rattus
Shen, RS; Abell, CW
Inhibition of dihydropteridine reductase by catechol estrogens.
J Neurosci Res
10
251-9
1983
Homo sapiens
Nakanisi, N; Kobayashi, H; Yamada, S
NADH-specific dihydropteridine reductase in mastocytoma P-815 cells.
Comp Biochem Physiol B
78
515-8
1984
Bos taurus, Mus musculus
Lipson, A; Yu, J; O'Halloran, M; Potter, M; Wilken, B
Dihydropteridine reductase deficiency: non-response to oral tetrahydrobiopterin load test.
J Inherit Metab Dis
7
69-71
1984
Homo sapiens
van der Heiden, C; Brink, W
Spectral studies of the interaction of the substrate 'quinonoid' 6-methyl dihydropterine and the coenzyme NADH used as marker in the dihydropteridine reductase assay.
J Inherit Metab Dis
5
132-6
1982
Indicator, Homo sapiens
Arai, N; Narisawa, K; Hayakawa, H; Tada, K
Hyperphenylalaninemia due to dihydropteridine reductase deficiency: diagnosis by enzyme assays on dried blood spots.
Pediatrics
70
426-30
1982
Homo sapiens
Milstien, S; Kaufman, S; Summer, GK
Hyperphenylalaninemia due to dihydropteridine reductase deficiency: diagnosis by measurement of oxidized and reduced pterins in urine.
Pediatrics
65
806-10
1980
Homo sapiens
Narisawa, K; Arai, N; Ishizawa, S; Ogasawara, Y; Onuma, A; Iinuma, K; Tada, K
Dihydropteridine reductase deficiency: diagnosis by leukocyte enzyme assay.
Clin Chim Acta
105
335-42
1980
Homo sapiens, Bos taurus
Tada, K; Narisawa, K; Arai, N; Ogasawara, Y; Ishizawa, S
A sibling case of hyperphenylalaninemia due to a deficiency of dihydropteridine reductase: biochemical and pathological findings.
Tohoku J Exp Med
132
123-31
1980
Homo sapiens
Smooker, PM; Howells, DW; Cotton, RG
Identification and in vitro expression of mutations causing dihydropteridine reductase deficiency.
Biochemistry
32
6443-9
1993
Escherichia coli
Dianzani, I; de Sanctis, L; Smooker, PM; Gough, TJ; Alliaudi, C; Brusco, A; Spada, M; Blau, N; Dobos, M; Zhang, HP; Yang, N; Ponzone, A; Armarego, WL; Cotton, RG
Dihydropteridine reductase deficiency: physical structure of the QDPR gene, identification of two new mutations and genotype-phenotype correlations.
Hum Mutat
12
267-73
1998
Homo sapiens
Altindağ, ZZ; Sahin, G; Inanici, F; Hasçelik, Z
Urinary neopterin excretion and dihydropteridine reductase activity in rheumatoid arthritis.
Rheumatol Int
18
107-11
1998
Homo sapiens
Altindag, ZZ; Sahin, G; Işimer, A; Akpek, G; Kansu, E
Dihydropteridine reductase activity and neopterin levels in leukemias and lymphomas: is there any correlation between these two parameters?
Leuk Lymphoma
35
367-74
1999
Homo sapiens
Lee, PL; Halloran, C; Cross, AR; Beutler, E
NADH-ferric reductase activity associated with dihydropteridine reductase.
Biochem Biophys Res Commun
271
788-95
2000
Sus scrofa, Mammalia, Dialysis
Kalkanoglu, HS; Romstad, A; Coşkun, T; Güttler, F
Evaluation of a fetus at risk for dihydropteridine reductase deficiency by direct mutation analysis using denaturing gradient gel electrophoresis.
Prenat Diagn
21
868-70
2001
Homo sapiens
Altindag, ZZ; Baydar, T; Engin, AB; Sahin, G
Effects of the metals on dihydropteridine reductase activity.
Toxicol In Vitro
17
533-7
0
Homo sapiens
Ye, J; Qiu, WJ; Han, LS; Zhang, HW; Zhou, JD; Gao, XL; Wang, Y; Gu, XF
[Diagnosis, treatment and gene mutation analysis of the first case with dihydropteridine reductase deficiency in the mainland of China]
Zhonghua Er Ke Za Zhi
46
281-5
2008
Homo sapiens
Porta, F; Mussa, A; Concolino, D; Spada, M; Ponzone, A
Dopamine agonists in dihydropteridine reductase deficiency.
Mol Genet Metab
2012
Homo sapiens
Ventzke, A; Hoffmann, J; Crushell, E; Monavari, A; Mayne, PD; Knerr, I
'Malignant Phenylketonuria' (PKU) Due to Dihydropteridine Reductase (DHPR) Deficiency.
Ir Med J
108
312-4
0
Homo sapiens
Takahashi, Y; Manabe, Y; Nakano, Y; Yunoki, T; Kono, S; Narai, H; Furujo, M; Abe, K
Parkinsonism in Association with Dihydropteridine Reductase Deficiency.
Case Rep Neurol
9
17-21
0
Homo sapiens
Vitturi, N; Lenzini, L; Luisi, C; Carecchio, M; Gugelmo, G; Francini-Pesenti, F; Avogaro, A
High prolactin levels in dihydropteridine reductase deficiency: A sign of therapy failure or additional pathology?
JIMD Rep
61
48-51
2021
Homo sapiens
Altamura, AC; Bonati, M; Brunello, N; Giordano, PL; Algeri, S
The activity of some neurotransmitter-synthetizing enzymes in experimental cobalt epilepsy.
Neurosci Lett
7
83-7
1978
Rattus, Areas
Blau, N; Kierat, L; Matasovic, A; Leimbacher, W; Heizmann, CW; Guardamagna, O; Ponzone, A
Antenatal diagnosis of tetrahydrobiopterin deficiency by quantification of pterins in amniotic fluid and enzyme activity in fetal and extrafetal tissue.
Clin Chim Acta
226
159-69
1994
Homo sapiens
Blau, N; Thony, B; Spada, M; Ponzone, A
Tetrahydrobiopterin and inherited hyperphenylalaninemias.
Turk J Pediatr
38
19-35
0
Homo sapiens
Blau, N; Barnes, I; Dhondt, JL
International database of tetrahydrobiopterin deficiencies.
J Inherit Metab Dis
19
8-14
1996
Homo sapiens
Ferraris, S; Guardamagna, O; Bracco, G; Ponzone, A
[Trial of indirect screening of tetrahydrobiopterin deficiency]
Pediatrie
42
549-55
1987
Homo sapiens
Niederwieser, A; Ponzone, A; Curtius, HC
Differential diagnosis of tetrahydrobiopterin deficiency.
J Inherit Metab Dis
8 Suppl 1
34-8
1985
Homo sapiens
Shintaku, H; Isshiki, G; Hase, Y; Tsuruhara, T; Oura, T
Normal pterin values in urine and serum in neonates and its age-related change throughout life.
J Inherit Metab Dis
5
241-2
1982
Crithidia fasciculata, Homo sapiens
Niederwieser, A; Curtius, HC; Gitzelmann, R; Otten, A; Baerlocher, K; Blehovà, B; Berlow, S; Gröbe, H; Rey, F; Schaub, J; Scheibenreiter, S; Schmidt, H; Viscontini, M
Excretion of pterins in phenylketonuria and phenylketonuria variants.
Helv Paediatr Acta
35
335-42
1980
Homo sapiens
Smith, I; Howells, DW; Hyland, K
Pteridines and mono-amines: relevance to neurological damage.
Postgrad Med J
62
113-23
1986
Homo sapiens
Bonafé, L; Thöny, B; Leimbacher, W; Kierat, L; Blau, N
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Clin Chem
47
477-85
2001
Homo sapiens
Zurflüh, MR; Giovannini, M; Fiori, L; Fiege, B; Gokdemir, Y; Baykal, T; Kierat, L; Gärtner, KH; Thöny, B; Blau, N
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Mol Genet Metab
86 Suppl 1
S96-103
2005
Homo sapiens
Opladen, T; Abu Seda, B; Rassi, A; Thny, B; Hoffmann, GF; Blau, N
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
J Inherit Metab Dis
2011
Homo sapiens
Arning, E; Bottiglieri, T
LC-MS/MS Analysis of Cerebrospinal Fluid Metabolites in the Pterin Biosynthetic Pathway.
JIMD Rep
2014
Homo sapiens
Carducci, C; Amayreh, W; Ababneh, H; Mahasneh, A; Al Rababah, B; Al Qaqa, K; Al Aqeel, M; Artiola, C; Tolve, M; D'Amici, S; Shen, N; Yu, Y; Hillert, A; Himmelreich, N; Okun, JG; Hoffmann, GF; Blau, N
Molecular genetics of phenylketonuria and tetrahydrobiopterin deficiency in Jordan.
JIMD Rep
55
59-67
2020
Homo sapiens
Himmelreich, N; Blau, N; Thny, B
Molecular and metabolic bases of tetrahydrobiopterin (BH4) deficiencies.
Mol Genet Metab
133
123-136
2021
Homo sapiens
LinWu, SW; Wang, AH; Peng, FC
Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine.
Expert Opin Drug Metab Toxicol
6
967-81
2010
Escherichia coli, Homo sapiens, Areas
Ribas de Pouplana, L; Fothergill-Gilmore, LA
The active site architecture of a short-chain dehydrogenase defined by site-directed mutagenesis and structure modeling.
Biochemistry
33
7047-55
1994
Rattus, Drosophila
Tsigelny, I; Baker, ME
Structures important in mammalian 11 beta- and 17 beta-hydroxysteroid dehydrogenases.
J Steroid Biochem Mol Biol
55
589-600
1995
Homo sapiens, Rattus, Streptomyces hydrogenans
Baker, ME
Sequence analysis of steroid- and prostaglandin-metabolizing enzymes: application to understanding catalysis.
Steroids
59
248-58
1994
Rattus, Streptomyces hydrogenans
Jennings, I; Cotton, R
Structural similarities among enzyme pterin binding sites as demonstrated by a monoclonal anti-idiotypic antibody.
J Biol Chem
265
1885-9
1990
Mus sp.
Farrugia, R; Scerri, CA; Montalto, SA; Parascandolo, R; Neville, BG; Felice, AE
Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population.
Mol Genet Metab
90
277-83
2007
Homo sapiens
Kaufman, S; Berlow, S; Summer, GK; Milstien, S; Schulman, JD; Orloff, S; Spielberg, S; Pueschel, S
Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria.
N Engl J Med
299
673-9
1978
Homo sapiens
Shinozaki, K; Hirayama, A; Nishio, Y; Yoshida, Y; Ohtani, T; Okamura, T; Masada, M; Kikkawa, R; Kodama, K; Kashiwagi, A
Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress.
J Am Coll Cardiol
38
1821-8
2001
Homo sapiens, Rattus
Shen, RS; Zhang, YX
Antioxidation activity of tetrahydrobiopterin in pheochromocytoma PC 12 cells.
Chem Biol Interact
78
307-19
1991
Armoracia rusticana, Ovis aries, Rattus
Yanai, K; Iinuma, K; Matsuzawa, T; Ito, M; Miyabayashi, S; Narisawa, K; Ido, T; Yamada, K; Tada, K
Cerebral glucose utilization in pediatric neurological disorders determined by positron emission tomography.
Eur J Nucl Med
13
292-6
1987
Homo sapiens
Hasegawa, H; Nakanishi, N; Akino, M
Stoichiometric studies on the oxidation of tetrahydropterin with ferri-cytochrome c.
J Biochem (Tokyo)
84
499-506
1978
Electron
Kaufman, S; Pollock, RJ; Summer, GK; Das, AK; Hajra, AK
Dependence of an alkyl glycol-ether monooxygenase activity upon tetrahydropterins.
Biochim Biophys Acta
1040
19-27
1990
Rattus, Electron
Danks, DM; Schlesinger, P; Firgaira, F; Cotton, RG; Watson, BM; Rembold, H; Hennings, G
Malignant hyperphenylalaninemia--clinical features, biochemical findings, and experience with administration of biopterins.
Pediatr Res
13
1150-5
1979
Homo sapiens
Curtius, HC; Matasovic, A; Schoedon, G; Kuster, T; Guibaud, P; Giudici, T; Blau, N
7-Substituted pterins. A new class of mammalian pteridines.
J Biol Chem
265
3923-30
1990
Homo sapiens
Trefz, F; Lichtenberger, O; Blau, N; Muntau, AC; Feillet, F; Blanger-Quintana, A; van Spronsen, F; Munafo, A
Tetrahydrobiopterin (BH4) responsiveness in neonates with hyperphenylalaninemia: A semi-mechanistically-based, nonlinear mixed-effect modeling.
Mol Genet Metab
2015
Homo sapiens
Smith, I; Clayton, BE; Wolff, OH
New variant of phenylketonuria with progressive neurological illness unresponsive to phenylalanine restriction.
Lancet
1
1108-11
1975
Homo sapiens
Schlesinger, P; Watson, BM; Cotton, RG; Danks, DM
Urinary dihydroxanthopterin in the diagnosis of malignant hyperphenylalaninemia and phenylketonuria.
Clin Chim Acta
92
187-95
1979
Homo sapiens
Ning, C; Liu, SR; Wei, H; Wang, S; Shu, D; Blau, N; Wang, MT
The screening diagnosis of tetrahydrobiopterin deficient phenylketonuria.
J Tongji Med Univ
12
216-8
1992
Homo sapiens
Lenzi, G; Pistone, D; Zammarchi, E; Benini, MP; La Torre, A; Matteoni, D
DHPR activity decrease in dried blood spots stored at 4 degrees C.
Enzyme
41
43-6
1989
Homo sapiens
Snyderman, SE; Sansaricq, C; Pulmones, MT
Successful long term therapy of biopterin deficiency.
J Inherit Metab Dis
10
260-6
1987
Homo sapiens
Kawashima, H; Kawano, M; Masaki, A; Sato, T
Three cases of untreated classical PKU: a report on cataracts and brain calcification.
Am J Med Genet
29
89-93
1988
Homo sapiens
Eggar, C; Hamon, CG; Morar, C; Al-Salihi, F; Blair, JA; Barford, PA
The effect of lead on tetrahydrobiopterin metabolism. A possible mechanism for neurotoxicity.
Clin Chim Acta
161
103-9
1986
Homo sapiens, Rattus
Smith, I; Hyland, K; Kendall, B
Clinical role of pteridine therapy in tetrahydrobiopterin deficiency.
J Inherit Metab Dis
8 Suppl 1
39-45
1985
Homo sapiens
Butler, IJ; O'Flynn, ME; Seifert, WE; Howell, RR
Neurotransmitter defects and treatment of disorders of hyperphenylalaninemia.
J Pediatr
98
729-33
1981
Homo sapiens
Ponzone, A; Guardamagna, O; Spada, M; Ponzone, R; Sartore, M; Kierat, L; Heizmann, CW; Blau, N
Hyperphenylalaninemia and pterin metabolism in serum and erythrocytes.
Clin Chim Acta
216
63-71
1993
Homo sapiens
Smooker, PM; Cotton, RG; Lipson, A
Prenatal diagnosis of DHPR deficiency by direct detection of mutation.
Prenat Diagn
13
881-4
1993
insertion sequences
Romstad, A; Kalkanoğlu, HS; Coşkun, T; Demirkol, M; Tokatli, A; Dursun, A; Baykal, T; Ozalp, I; Guldberg, P; Güttler, F
Molecular analysis of 16 Turkish families with DHPR deficiency using denaturing gradient gel electrophoresis (DGGE).
Hum Genet
107
546-53
2000
Homo sapiens
Wang, L; Yu, WM; Li, XW; He, C; Chang, M; Shen, M; Zhao, SP; Fu, GX; Shen, S; Liu, TT; Hsiao, KJ
[Study on tetrahydrobiopterin deficiency in Northern Chinese population]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
23
275-9
2006
Homo sapiens
Karam, PE; Daher, RT; Moller, LB; Mikati, MA
Experience With Hyperphenylalaninemia in a Developing Country: Unusual Clinical Manifestations and a Novel Gene Mutation.
J Child Neurol
2010
Homo sapiens
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