Information on EC 1.5.1.26 - beta-alanopine dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.5.1.26
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RECOMMENDED NAME
GeneOntology No.
beta-alanopine dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
pyruvate fermentation to opines
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SYSTEMATIC NAME
IUBMB Comments
N-(D-1-Carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
113573-64-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
weak activity
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Manually annotated by BRENDA team
Anthopleura pacifica
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
weak activity
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Glycera sp.
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Manually annotated by BRENDA team
weak activity
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Manually annotated by BRENDA team
weak activity
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
no activity in Aplysia juliana
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Manually annotated by BRENDA team
no activity in Aplysia kurodai
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Manually annotated by BRENDA team
no activity in Asterias amurensis
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Manually annotated by BRENDA team
no activity in Asterina pectinifera
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Manually annotated by BRENDA team
no activity in Aurelia aurita
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Manually annotated by BRENDA team
no activity in Balanus cariosus
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Manually annotated by BRENDA team
no activity in Cerebratulus sp.
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Manually annotated by BRENDA team
no activity in Chaetopterus variopedatus
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Manually annotated by BRENDA team
no activity in Clymenella torquata
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Manually annotated by BRENDA team
no activity in Crepidula fornicata
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Manually annotated by BRENDA team
no activity in Dentalium pilsbryi
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Manually annotated by BRENDA team
no activity in Halichondria japonica
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Manually annotated by BRENDA team
no activity in Haliotis rufescens
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Manually annotated by BRENDA team
no activity in Halocynthia roretzi
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Manually annotated by BRENDA team
no activity in Hexagrammos otakii
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Manually annotated by BRENDA team
no activity in Hydroides sp.
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Manually annotated by BRENDA team
no activity in Lepidonotus sp.
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Manually annotated by BRENDA team
no activity in Lineus sp.
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Manually annotated by BRENDA team
no activity in Liolophura japonica
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Manually annotated by BRENDA team
no activity in Littorina littorea
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Manually annotated by BRENDA team
no activity in Loligo bleekeri
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Manually annotated by BRENDA team
no activity in Lyonsia hyalina
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Manually annotated by BRENDA team
no activity in Membranipora tenuis
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Manually annotated by BRENDA team
no activity in Mopalia muscosa
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Manually annotated by BRENDA team
no activity in Mya arenaria
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Manually annotated by BRENDA team
no activity in Nereis sp.
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Manually annotated by BRENDA team
no activity in Nucella lapillus
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Manually annotated by BRENDA team
no activity in Nucula proxima
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Manually annotated by BRENDA team
no activity in Octopus membranaceus
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Manually annotated by BRENDA team
no activity in Octopus vulgaris
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Manually annotated by BRENDA team
no activity in Oncorhynchus keta
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Manually annotated by BRENDA team
no activity in Pagurus samuelis
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Manually annotated by BRENDA team
no activity in Priapulus sp.
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Manually annotated by BRENDA team
no activity in Pugettia quadridens
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Manually annotated by BRENDA team
no activity in Solemya velum
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Manually annotated by BRENDA team
no activity in Spisula solidissima
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Manually annotated by BRENDA team
no activity in Stichopus japonicus
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Manually annotated by BRENDA team
no activity in Strongylocentrotus nudus
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Manually annotated by BRENDA team
no activity in Tegula funebralis
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Manually annotated by BRENDA team
no activity in Terebratalia transversa
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Manually annotated by BRENDA team
no activity in Todarodes pacificus
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Manually annotated by BRENDA team
no activity in Urechis sp.
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Phascolopsis sp.
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Manually annotated by BRENDA team
Phascolosoma sp.
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
weak activity
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Manually annotated by BRENDA team
Themiste sp.
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-Ala + pyruvate + NADH
beta-alanopine + NAD+ + H2O
show the reaction diagram
beta-alanine + pyruvate + NADH
beta-alanopine + NAD+ + H2O
show the reaction diagram
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specific for beta-alanine
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?
beta-alanopine + NAD+ + H2O
beta-alanine + pyruvate + NADH + H+
show the reaction diagram
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?
additional information
?
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tauropine, alanopine, strombine, and octopine are poor substrates
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
beta-alanine + pyruvate + NADH
beta-alanopine + NAD+ + H2O
show the reaction diagram
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specific for beta-alanine
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?
beta-alanopine + NAD+ + H2O
beta-alanine + pyruvate + NADH + H+
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
14.3
beta-Alanine
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pH 7.1, 30°C
35.2
beta-alanopine
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pH 9.0, 30°C
0.078
NAD+
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pH 9.0, 30°C
0.032
NADH
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pH 7.1, 30°C
0.19
pyruvate
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pH 7.1, 30°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
13
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purified enzyme, reverse reaction
190.5
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purified enzyme, forward reaction
additional information
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.1
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opine biosynthetic reaction direction
9
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catabolic reaction direction
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 10
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half-maximal forward reaction at pH 5.8, half-maximal reverse reaction at pH 8.5
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
39700
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gel filtration
40800
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x * 40800, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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x * 40800, SDS-PAGE
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
enzyme activity is not affected by anoxic exposure
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
native enzyme by ammonium sulfate fractionation and several chromatographic steps, 705.6fold
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme activity is not affected by anoxic exposure
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