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Reference on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kutzbach, C.; Stokstad, E.L.R.
Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine
Biochim. Biophys. Acta
250
459-477
1971
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Pearson, A.G.M.; Turner, A.J.
Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase
Nature
258
173-174
1975
Sus scrofa
Manually annotated by BRENDA team
Matthews, R.G.; Daubner, S.C.
Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues
Adv. Enzyme Regul.
20
123-131
1982
Sus scrofa
Manually annotated by BRENDA team
Vanoni, M.A.; Ballou, D.P.; Matthews, R.G.
Methylenetetrahydrofolate reductase. Steady state and rapid reaction studies on the NADPH-methylenetetrahydrofolate, NADPH-menadione, and methyltetrahydrofolate-menadione oxidoreductase activities of the enzyme
J. Biol. Chem.
258
11510-11514
1983
Sus scrofa
Manually annotated by BRENDA team
Varalakshmi, K.; Savithri, H.S.; Rao, N.A.
Identification of amino acid residues essential for enzyme activity of sheep liver 5,10-methylenetetrahydrofolate reductase
Biochem. J.
236
295-298
1986
Ovis aries
Manually annotated by BRENDA team
Matthews, R.G.
Methylenetetrahydrofolate reductase from pig liver
Methods Enzymol.
122
372-381
1986
Sus scrofa
Manually annotated by BRENDA team
Jencks, D.A.; Matthews, R.G.
Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium
J. Biol. Chem.
262
2485-2493
1987
Sus scrofa
Manually annotated by BRENDA team
Zhou, J.; Kang, S.S.; Wong, P.W.K.; Fournier, B.; Rozen, R.
Purification and characterization of methylenetetrahydrofolate reductase from human cadaver liver [published erratum appears in Biochem Med Metab Biol 1990 Oct;44(2):200]
Biochem. Med. Metab. Biol.
43
234-242
1990
Homo sapiens
Manually annotated by BRENDA team
Green, J.M.; Ballou, D.P.; Matthews, R.G.
Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism
FASEB J.
2
42-47
1988
Sus scrofa
Manually annotated by BRENDA team
Black, K.A.; Eells, J.T.; Noker, P.E.; Hawtrey, C.A.; Tephly, T.R.
Role of hepatic tetrahydrofolate in the species difference in methanol toxicity
Proc. Natl. Acad. Sci. USA
82
3854-3858
1985
Cercocebus sp., Rattus norvegicus
Manually annotated by BRENDA team
Matthews, R.G.; Ghose, C.; Green, J.M.; Matthews, K.D.; Dunlap, R.B.
Folylpolyglutamates as substrates and inhibitors of folate-dependent enzymes
Adv. Enzyme Regul.
26
157-171
1987
Sus scrofa
Manually annotated by BRENDA team
Burton, E.G.; Sallach, H.J.
Methylenetetrahydrofolate reductase in the rat central nervous system: intracellular and regional distribution
Arch. Biochem. Biophys.
166
483-494
1975
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Matthews, R.G.; Kaufmann S.
Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase
J. Biol. Chem.
255
6014-6017
1980
Sus scrofa
Manually annotated by BRENDA team
Guenther, B.D.; Sheppard, C.A.; Tran, P.; Rozen, R.; Matthews, R.G.; Ludwig, M.L.
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
Nat. Struct. Biol.
6
359-365
1999
Escherichia coli (P0AEZ1)
Manually annotated by BRENDA team
Matthews, R.G.; Sheppard, C.; Goulding, C.
Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology
Eur. J. Pediatr.
157
54-59
1998
Escherichia coli, Homo sapiens, Sus scrofa
-
Manually annotated by BRENDA team
Ravera, M.; Viazzi, F.; Berruti, V.; Leoncini, G.; Zagami, P.; Bezante, G.P.; Rosatto, N.; Ravazzolo, R.; Pontremoli, R.; Deferrari, G.
5,10-Methylenetetrahydrofolate reductase polymorphism and early organ damage in primary hypertension
Am. J. Hypertens.
14
371-376
2001
Homo sapiens
Manually annotated by BRENDA team
Shan, X.; Wang, L.; Hoffmaster, R.; Kruger, W.D.
Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae
J. Biol. Chem.
274
32613-32618
1999
Homo sapiens
Manually annotated by BRENDA team
Suormala, T.; Gamse, G.; Fowler, B.
5,10-Methylenetetrahydrofolate reductase (MTHFR) assay in the forward direction: residual activity in MTHFR deficiency
Clin. Chem.
48
835-843
2002
Homo sapiens
Manually annotated by BRENDA team
Weisberg, I.; Tran, P.; Christensen, B.; Sibani, S.; Rozen, R.
A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
Mol. Genet. Metab.
64
169-172
1998
Homo sapiens (P42898)
Manually annotated by BRENDA team
Vanoni, M.A.; Lee, S.; Floss, H.G.; Matthews, R.G.
Stereochemistry of reduction of methylenetetrahydrofolate to methyltetrahydrofolate catalyzed by pig liver methylenetetrahydrofolate reductase
J. Am. Chem. Soc.
112
3987-3992
1990
Sus scrofa
-
Manually annotated by BRENDA team
Buchanan, J.M.
Methionine biosynthesis (hog liver)
Methods Enzymol.
17B
371-378
1971
Escherichia coli, Sus scrofa, Escherichia coli 113-3
-
Manually annotated by BRENDA team
Clark, J.E.; Ljungdahl, L.G.
Purification and properties of 5,10-methylenetetrahydrofolate reductase from Clostridium formicoaceticum
Methods Enzymol.
122
392-399
1986
Clostridium formicaceticum
Manually annotated by BRENDA team
Clark, J.E.; Ljungdahl, L.G.
Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum
J. Biol. Chem.
259
10845-10849
1984
Clostridium formicaceticum
Manually annotated by BRENDA team
Katzen, H.M.; Buchanan, J.M.
Enzymatic synthesis of the methyl group of methionine. VIII. Repression derepression, purification, and properties of 5,10-methylene-tetrahydrofolate reductase from Escherichia coli
J. Biol. Chem.
240
825-835
1965
Escherichia coli, Escherichia coli 113-3
Manually annotated by BRENDA team
Kutzbach, C.; Stokstad, E.L.R.
Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine
Biochim. Biophys. Acta
139
217-220
1967
Rattus norvegicus
Manually annotated by BRENDA team
Cheng, F.W.; Shane, B.; Stokstad, E.L.R.
Pentaglutamate derivatives of folate as substrates for rat liver tetrahydropteroylglutamate methyltransferase and 5,10-methylenetetrahydrofolate reductase
Can. J. Biochem.
53
1020-1027
1975
Rattus norvegicus
-
Manually annotated by BRENDA team
Blom, H.J.
Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia
Eur. J. Pediatr.
157
131-134
1998
Homo sapiens
-
Manually annotated by BRENDA team
McNulty, H.; McKinley, M.C.; Wilson, B.; McPartlin, J.; Strain, J.J.; Weir, D.G.; Scott, J.M.
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: Implications for riboflavin requirements
Am. J. Clin. Nutr.
76
436-441
2002
Homo sapiens
Manually annotated by BRENDA team
Engbersen, A.M.T.; Franken, D.G.; Boers, G.H.J.; Stevens, E.M.B.; Trijbels, F.J.M.; Blom, H.J.
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia
Am. J. Hum. Genet.
56
142-150
1995
Homo sapiens
Manually annotated by BRENDA team
Rosenblatt, D.S.; Lue-Shing, H.; Matiaszuk, N.; Low-Nang, L.; Arzoumanian, A.; Cooper, B.A.
Thermolability of residual methylene-tetrahydrofolate reductase (MR) activity, methionine synthase activity and methyl-cobalamin levels in cultured fibroblasts from patients with MR deficiency
Adv. Exp. Med. Biol.
338
703-706
1993
Homo sapiens
Manually annotated by BRENDA team
Kluijtmans, L.A.J.; den Heijer, M.; Reitsma, P.H.; Heil, S.G.; Blom, H.J.; Rosendaal, F.R.
Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis
Thromb. Haemost.
79
254-258
1998
Homo sapiens
Manually annotated by BRENDA team
Roje, S.; Wang, H.; McNeil, S.D.; Raymond, R.K.; Appling, D.R.; Shachar-Hill, Y.; Bohnert, H.J.; Hanson, A.D.
Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants
J. Biol. Chem.
274
36089-36096
1999
Arabidopsis sp., Escherichia coli, Zea mays (Q9SE94), Zea mays
Manually annotated by BRENDA team
Yamada, K.; Chen, Z.; Rozen, R.; Matthews, R.G.
Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase
Proc. Natl. Acad. Sci. USA
98
14853-14858
2001
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Trimmer, E.E.; Ballou, D.P.; Ludwig, M.L.; Matthews, R.G.
Folate activation and catalysis in methylenetetrahydrofolate reductase from Escherichia coli: Roles for aspartate 120 and glutamate 28
Biochemistry
40
6216-6226
2001
Escherichia coli
Manually annotated by BRENDA team
Raymond, R.K.; Kastanos, E.K.; Appling, D.R.
Saccharomyces cerevisiae expresses two genes encoding isoenzymes of methylenetetrahydrofolate reductase
Arch. Biochem. Biophys.
372
300-308
1999
Saccharomyces cerevisiae, Schizosaccharomyces pombe, Saccharomyces cerevisiae DAY4
Manually annotated by BRENDA team
Rozen, R.
Methylenetetrahydrofolate reductase: a link between folate and riboflavin?
Am. J. Clin. Nutr.
76
301-302
2002
Homo sapiens
Manually annotated by BRENDA team
Hettmann, T.; Siddiqui, R.A.; Frey, C.; Santos-Silva, T.; Romao, M.J.; Diekmann, S.
Mutagenesis study on amino acids around the molybdenum center of the periplasmic nitrate reductase from Ralstonia eutropha
Biochem. Biophys. Res. Commun.
320
1211-1219
2004
Cupriavidus necator
Manually annotated by BRENDA team
Misra, S.K.; Bhakuni, V.
Unique holoenzyme dimers of the tetrameric enzyme Escherichia coli methylenetetrahydrofolate reductase: characterization of structural features associated with modulation of the enzyme's function
Biochemistry
42
3921-3928
2003
Escherichia coli
Manually annotated by BRENDA team
Trimmer, E.E.; Ballou, D.P.; Galloway, L.J.; Scannell, S.A.; Brinker, D.R.; Casas, K.R.
Aspartate 120 of Escherichia coli methylenetetrahydrofolate reductase: evidence for major role in folate binding and catalysis and a minor role in flavin reactivity
Biochemistry
44
6809-6822
2005
Escherichia coli
Manually annotated by BRENDA team
Roje, S.; Chan, S.Y.; Kaplan, F.; Raymond, R.K.; Horne, D.W.; Appling, D.R.; Hanson, A.D.
Metabolic endineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo
J. Biol. Chem.
277
4056-4061
2002
Arabidopsis thaliana, Saccharomyces cerevisiae (P53128), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Naula, N.; Walther, C.; Baumann, D.; Schweingruber, M.E.
Two non-complementing genes encoding enzymatically active methylenetertrahydrofolate reductases control methionine requirement in fission yeast Schizosaccharomyces pombe
Yeast
19
841-848
2002
Schizosaccharomyces pombe
Manually annotated by BRENDA team
Bonnard, N.; Tresierra-Ayala, A.; Bedmar, E.J.; Delgado, M.J.
Molybdate-dependent expression of the periplasmic nitrate reductase in Bradyrhizobium japonicum
Biochem. Soc. Trans.
33
127-129
2005
Bradyrhizobium japonicum
Manually annotated by BRENDA team
Brige, A.; Leys, D.; Meyer, T.E.; Cusanovich, M.A.; Van Beeumen, J.J.
The 1.25 A resolution structure of the diheme NapB subunit of soluble nitrate reductase reveals a novel cytochrome c fold with a stacked heme arrangement
Biochemistry
41
4827-4836
2002
Haemophilus influenzae
Manually annotated by BRENDA team
Delgado, M.J.; Bonnard, N.; Tresierra-Ayala, A.; Bedmar, E.J.; Muller, P.
The Bradyrhizobium japonicum napEDABC genes encoding the periplasmic nitrate reductase are essential for nitrate respiration
Microbiology
149
3395-3403
2003
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110
Manually annotated by BRENDA team
Arnoux, P.; Sabaty, M.; Alric, J.; Frangioni, B.; Guigliarelli, B.; Adriano, J.M.; Pignol, D.
Structural and redox plasticity in the heterodimeric periplasmic nitrate reductase
Nat. Struct. Biol.
10
928-934
2003
Cereibacter sphaeroides
Manually annotated by BRENDA team
Pejchal, R.; Sargeant, R.; Ludwig, M.L.
Structures of NADH and CH3-H4folate complexes of Escherichia coli methylenetetrahydrofolate reductase reveal a spartan strategy for a ping-pong reaction
Biochemistry
44
11447-11457
2005
Escherichia coli
Manually annotated by BRENDA team
Pejchal, R.; Campbell, E.; Guenther, B.D.; Lennon, B.W.; Matthews, R.G.; Ludwig, M.L.
Structural perturbations in the Ala --> Val polymorphism of methylenetetrahydrofolate reductase: how binding of folates may protect against inactivation
Biochemistry
45
4808-4818
2006
Escherichia coli
Manually annotated by BRENDA team
Vickers, T.J.; Orsomando, G.; de la Garza, R.D.; Scott, D.A.; Kang, S.O.; Hanson, A.D.; Beverley, S.M.
Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence
J. Biol. Chem.
281
38150-38158
2006
Leishmania major
Manually annotated by BRENDA team
Yamada, K.; Strahler, J.R.; Andrews, P.C.; Matthews, R.G.
Regulation of human methylenetetrahydrofolate reductase by phosphorylation
Proc. Natl. Acad. Sci. USA
102
10454-10459
2005
Homo sapiens
Manually annotated by BRENDA team
Greco, M.; Chiriaco, F.; Del Boccio, P.; Tagliaferro, L.; Acierno, R.; Menegazzi, P.; Pinca, E.; Pignatelli, F.; Storelli, C.; Federici, G.; Urbani, A.; Maffia, M.
A proteomic approach for the characterization of C677T mutation of the human gene methylenetetrahydrofolate reductase
Proteomics
6
5350-5361
2006
Homo sapiens
Manually annotated by BRENDA team
Lin, J.J.; Yueh, K.C.; Liu, C.S.; Liu, J.T.; Lin, S.Z.
5,10-methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinsons disease
Acta Neurol. Taiwan
16
150-157
2007
Homo sapiens
Manually annotated by BRENDA team
Elkins, J.S.; Johnston, S.C.; Ziv, E.; Kado, D.; Cauley, J.A.; Yaffe, K.
Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women
Am. J. Epidemiol.
166
672-678
2007
Homo sapiens
Manually annotated by BRENDA team
Boccia, S.; Hung, R.; Ricciardi, G.; Gianfagna, F.; Ebert, M.P.; Fang, J.Y.; Gao, C.M.; Goetze, T.; Graziano, F.; Lacasana-Navarro, M.; Lin, D.; Lopez-Carrillo, L.; Qiao, Y.L.; Shen, H.; Stolzenberg-Solomon, R.; Takezaki, T.; Weng, Y.R.; Zhang, F.F.; van Duijn, C.M.; Boffetta, P.; Taioli, E.
Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review
Am. J. Epidemiol.
167
505-516
2008
Homo sapiens
Manually annotated by BRENDA team
Hustad, S.; Midttun, O.; Schneede, J.; Vollset, S.E.; Grotmol, T.; Ueland, P.M.
The methylenetetrahydrofolate reductase 677C>T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism
Am. J. Hum. Genet.
80
846-855
2007
Homo sapiens
Manually annotated by BRENDA team
Martinez-Frias, M.L.
The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome
Am. J. Med. Genet. A
146A
1477-1482
2008
Homo sapiens
Manually annotated by BRENDA team
Muntjewerff, J.W.; Hoogendoorn, M.L.; Aukes, M.F.; Kahn, R.S.; Sinke, R.J.; Blom, H.J.; den Heijer, M.
No evidence for a preferential transmission of the methylenetetrahydrofolate reductase 677T allele in families with schizophrenia offspring
Am. J. Med. Genet. B Neuropsychiatr. Genet.
144B
891-894
2007
Homo sapiens
Manually annotated by BRENDA team
Gaysina, D.; Cohen, S.; Craddock, N.; Farmer, A.; Hoda, F.; Korszun, A.; Owen, M.J.; Craig, I.W.; McGuffin, P.
No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: Results of the depression case control (DeCC) study and a meta-analysis
Am. J. Med. Genet. B Neuropsychiatr. Genet.
147B
699-706
2007
Homo sapiens
Manually annotated by BRENDA team
Joensson, E.G.; Larsson, K.; Vares, M.; Hansen, T.; Wang, A.G.; Djurovic, S.; Ronningen, K.S.; Andreassen, O.A.; Agartz, I.; Werge, T.; Terenius, L.; Hall, H.
Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: An association study
Am. J. Med. Genet. B Neuropsychiatr. Genet.
147B
976-982
2007
Homo sapiens
Manually annotated by BRENDA team
Ananth, C.V.; Peltier, M.R.; De Marco, C.; Elsasser, D.A.; Getahun, D.; Rozen, R.; Smulian, J.C.; Smulian, J.C.
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption
Am. J. Obstet. Gynecol.
197
385e1-385e7
2007
Homo sapiens
Manually annotated by BRENDA team
Nagele, P.; Zeugswetter, B.; Wiener, C.; Burger, H.; Huepfl, M.; Mittlboeck, M.; Foedinger, M.
Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia
Anesthesiology
109
36-43
2008
Homo sapiens
Manually annotated by BRENDA team
Siraj, A.K.; Ibrahim, M.; Al-Rasheed, M.; Bu, R.; Bavi, P.; Jehan, Z.; Abubaker, J.; Murad, W.; Al-Dayel, F.; Ezzat, A.; El-Solh, H.; Uddin, S.; Al-Kuraya, K.
Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East
Ann. Hematol.
86
887-895
2007
Homo sapiens
Manually annotated by BRENDA team
Eroglu, A.; Egin, Y.; Cam, R.; Akar, N.
The 19-bp deletion of dihydrofolate reductase (DHFR), methylenetetrahydrofolate reductase (MTHFR) C677T, Factor V Leiden, prothrombin G20210A polymorphisms in cancer patients with and without thrombosis
Ann. Hematol.
88
73-76
2008
Homo sapiens
Manually annotated by BRENDA team
Pare, L.; Altes, A.; Ramon y Cajal, T.; Del Rio, E.; Alonso, C.; Sedano, L.; Barnadas, A.; Baiget, M.
Influence of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms on the disease-free survival of breast cancer patients receiving adjuvant 5-fluorouracil/methotrexate-based therapy
Anticancer Drugs
18
821-825
2007
Homo sapiens
Manually annotated by BRENDA team
Ko, K.H.; Kim, N.K.; Yim, D.J.; Hong, S.P.; Park, P.W.; Rim, K.S.; Kim, S.; Hwang, S.G.
Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population
Anticancer Res.
26
4229-4233
2007
Homo sapiens
Manually annotated by BRENDA team
Oh, D.; Kim, N.K.; Jang, M.J.; Kim, H.C.; Lee, J.H.; Lee, J.A.; Ahn, M.J.; Kim, C.S.; Kim, H.S.; Park, S.; Chio, H.S.; Min, Y.H.; Min, Y.H.
Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia
Anticancer Res.
27
3419-3424
2007
Homo sapiens
Manually annotated by BRENDA team
Shekari, M.; Sobti, R.C.; Kordi Tamandani, D.M.; Suri, V.
Impact of methylenetetrahydrofolate reductase (MTHFR) codon (677) and methionine synthase (MS) codon (2756) on risk of cervical carcinogenesis in North Indian population
Arch. Gynecol. Obstet.
278
517-524
2008
Homo sapiens
Manually annotated by BRENDA team
Rallidis, L.S.; Gialeraki, A.; Komporozos, C.; Vavoulis, P.; Pavlakis, G.; Travlou, A.; Lekakis, I.; Kremastinos, D.T.
Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction
Atherosclerosis
200
115-120
2008
Homo sapiens
Manually annotated by BRENDA team
Boccia, S.; Gianfagna, F.; Persiani, R.; La Greca, A.; Arzani, D.; Rausei, S.; Dugo, D.; Magistrelli, P.; Villari, P.; Van Duijn, C.M.; Ricciardi, G.
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population
Biomarkers
12
635-644
2007
Homo sapiens
Manually annotated by BRENDA team
Ruiz, J.R.; Hurtig-Wennloef, A.; Ortega, F.B.; Patterson, E.; Nilsson, T.K.; Castillo, M.J.; Sjoestroem, M.
Homocysteine levels in children and adolescents are associated with the methylenetetrahydrofolate reductase 677C>T genotype, but not with physical activity, fitness or fatness: the European Youth Heart Study
Br. J. Nutr.
97
255-262
2007
Homo sapiens
Manually annotated by BRENDA team
Sharp, L.; Little, J.; Brockton, N.T.; Cotton, S.C.; Masson, L.F.; Haites, N.E.; Cassidy, J.
Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
Br. J. Nutr.
99
379-389
2008
Homo sapiens
Manually annotated by BRENDA team
Jakubowska, A.; Gronwald, J.; Menkiszak, J.; Gorski, B.; Huzarski, T.; Byrski, T.; Edler, L.; Lubinski, J.; Scott, R.J.; Hamann, U.
Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks
Breast Cancer Res. Treat.
104
299-308
2007
Homo sapiens
Manually annotated by BRENDA team
Macis, D.; Maisonneuve, P.; Johansson, H.; Bonanni, B.; Botteri, E.; Iodice, S.; Santillo, B.; Penco, S.; Gucciardo, G.; DAiuto, G.; Rosselli Del Turco, M.; Amadori, M.; Costa, A.; Decensi, A.
Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis
Breast Cancer Res. Treat.
106
263-271
2007
Homo sapiens
Manually annotated by BRENDA team
Langsenlehner, T.; Renner, W.; Yazdani-Biuki, B.; Langsenlehner, U.
Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis
Breast Cancer Res. Treat.
107
459-460
2008
Homo sapiens
Manually annotated by BRENDA team
Pande, M.; Chen, J.; Amos, C.I.; Lynch, P.M.; Broaddus, R.; Frazier, M.L.
Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population
Cancer Epidemiol. Biomarkers Prev.
16
1753-1759
2007
Homo sapiens
Manually annotated by BRENDA team
Hekim, N.; Ergen, A.; Yaylim, I.; Yilmaz, H.; Zeybek, U.; Ozturk, O.; Isbir, T.
No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer
Cell Biochem. Funct.
25
115-117
2007
Homo sapiens
Manually annotated by BRENDA team
Sazci, A.; Ergul, E.; Aygun, C.; Akpinar, G.; Senturk, O.; Hulagu, S.
Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH)
Cell Biochem. Funct.
26
291-296
2008
Homo sapiens
Manually annotated by BRENDA team
Sun, D.F.; Weng, Y.R.; Chen, Y.X.; Lu, R.; Wang, X.; Fang, J.Y.
Knock-down of methylenetetrahydrofolate reductase reduces gastric cancer cell survival: An in vitro study
Cell Biol. Int.
32
879-887
2008
Homo sapiens
Manually annotated by BRENDA team
Doelek, B.; Eraslan, S.; Ero?lu, S.; Kesim, B.E.; Ulutin, T.; Yalciner, A.; Laleli, Y.R.; Goezuekirmizi, N.
Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients
Clin. Appl. Thromb. Hemost.
13
435-438
2007
Homo sapiens
Manually annotated by BRENDA team
Reljic, A.; Simundic, A.M.; Topic, E.; Nikolac, N.; Justinic, D.; Stefanovic, M.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study
Clin. Biochem.
40
981-985
2007
Homo sapiens
Manually annotated by BRENDA team
Sharma, R.; Hoskins, J.M.; Rivory, L.P.; Zucknick, M.; London, R.; Liddle, C.; Clarke, S.J.
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients
Clin. Cancer Res.
14
817-825
2008
Homo sapiens
Manually annotated by BRENDA team
Zee, R.Y.; Mora, S.; Cheng, S.; Erlich, H.A.; Lindpaintner, K.; Rifai, N.; Buring, J.E.; Ridker, P.M.
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women
Clin. Chem.
53
845-851
2007
Homo sapiens
Manually annotated by BRENDA team
Naghibalhossaini, F.; Mokarram, P.; Khalili, I.
Easy detection of 5,10-methylenetetrahydrofolate reductase 1298A/C genotype by mutagenically separated PCR assay
Clin. Chem. Lab. Med.
46
987-989
2008
Homo sapiens
Manually annotated by BRENDA team
Angius, A.; Simpore, J.; Persico, I.; Sassu, A.; Prodi, D.A.; Musumeci, S.
Methylenetetrahydrofolate reductase gene polymorphisms in Burkina Faso: impact on plasma fasting homocysteine and after methionine loading test
Clin. Lab.
53
29-33
2007
Homo sapiens
Manually annotated by BRENDA team
Spiroski, I.; Kedev, S.; Antov, S.; Arsov, T.; Krstevska, M.; Dzhekova-Stojkova, S.; Kostovska, S.; Trajkov, D.; Petlichkovski, A.; Strezova, A.; Efinska-Mladenovska, O.; Spiroski, M.
Association of methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genetic polymorphisms with occlusive artery disease and deep venous thrombosis in Macedonians
Croat. Med. J.
49
39-49
2008
Homo sapiens
Manually annotated by BRENDA team
Eroglu, Z.; Erdogan, M.; Tetik, A.; Karadeniz, M.; Cetinalp, S.; Kosova, B.; Gunduz, C.; Ozgen, A.G.; Yilmaz, C.
The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy
Diabetes Metab. Res. Rev.
23
621-624
2007
Homo sapiens
Manually annotated by BRENDA team
Serin, E.; Gueclue, M.; Atac, F.B.; Verdi, H.; Kayaselcuk, F.; Ozer, B.; Bilezikci, B.; Yilmaz, U.
Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease
Digest. Dis. Sci.
52
1183-1186
2007
Homo sapiens
Manually annotated by BRENDA team
Srivastava, A.; Pandey, S.N.; Pandey, P.; Choudhuri, G.; Mittal, B.
No association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in susceptibility to gallbladder cancer
DNA Cell Biol.
27
127-132
2008
Homo sapiens (P42898)
Manually annotated by BRENDA team
Heur, M.; Kosmorsky, G.S.; Peachey, N.S.; Bala, E.
Branch retinal artery occlusion associated with compound heterozygous genotype for methylenetetrahydrofolate reductase
Doc. Ophthalmol.
114
163-168
2007
Homo sapiens
Manually annotated by BRENDA team
Sun, L.; Sun, Y.H.; Wang, B.; Cao, H.Y.; Yu, C.
Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis
Eur. J. Cancer Prev.
17
446-452
2008
Homo sapiens
Manually annotated by BRENDA team
Lewis, S.J.; Lawlor, D.A.; Nordestgaard, B.G.; Tybjaerg-Hansen, A.; Ebrahim, S.; Zacho, J.; Ness, A.; Leary, S.; Smith, G.D.
The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
Eur. J. Endocrinol.
159
35-40
2008
Homo sapiens
Manually annotated by BRENDA team
Qian, X.; Lu, Z.; Tan, M.; Liu, H.; Lu, D.
A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension
Eur. J. Hum. Genet.
15
1239-1245
2007
Homo sapiens
Manually annotated by BRENDA team
Summers, C.M.; Hammons, A.L.; Mitchell, L.E.; Woodside, J.V.; Yarnell, J.W.; Young, I.S.; Evans, A.; Whitehead, A.S.
Influence of the cystathionine beta-synthase 844ins68 and methylenetetrahydrofolate reductase 677C>T polymorphisms on folate and homocysteine concentrations
Eur. J. Hum. Genet.
16
1010-1013
2008
Homo sapiens
Manually annotated by BRENDA team
Stonek, F.; Hafner, E.; Metzenbauer, M.; Stuempflen, I.; Philipp, K.
Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow
Eur. J. Obstet. Gynecol. Reprod. Biol.
140
178-182
2008
Homo sapiens
Manually annotated by BRENDA team
Muntjewerff, J.W.; Gellekink, H.; den Heijer, M.; Hoogendoorn, M.L.; Kahn, R.S.; Sinke, R.J.; Blom, H.J.
Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia
Eur. Neuropsychopharmacol.
18
99-106
2008
Homo sapiens
Manually annotated by BRENDA team
Azarpira, N.; Ramzi, M.; Aghdaie, M.H.; Daraie, M.; Geramizadeh, B.
Methylenetetrahydrofolate reductase C677T genotypes and clinical outcome following hematopoietic cell transplant
Exp. Clin. Transplant.
5
693-697
2007
Homo sapiens
Manually annotated by BRENDA team
Azarpira, N.; Raisjalali, G.; Darai, M.
Polymorphism of the methylenetetrahydrofolate reductase C677T gene with chronic allograft nephropathy in renal transplant recipients
Exp. Clin. Transplant.
6
54-58
2008
Homo sapiens
Manually annotated by BRENDA team
Weger, W.; Hofer, A.; Stanger, O.; Wolf, P.; El-Shabrawi, Y.; Renner, W.; Kerl, H.; Salmhofer, W.
The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis
Exp. Dermatol.
17
748-751
2008
Homo sapiens
Manually annotated by BRENDA team
Chwatko, G.; Boers, G.H.; Strauss, K.A.; Shih, D.M.; Jakubowski, H.
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice
FASEB J.
21
1707-1713
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hecht, S.; Pavlik, R.; Lohse, P.; Noss, U.; Friese, K.; Thaler, C.J.
Common 677C-->T mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis
Fertil. Steril.
91
56-61
2008
Homo sapiens
Manually annotated by BRENDA team
Ozger, H.; Kilicoglu, O.; Yilmaz, H.; Ergen, H.A.; Yaylim, I.; Zeybek, U.; Isbir, T.
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients
Folia Biol. (Praha)
54
53-57
2008
Homo sapiens
Manually annotated by BRENDA team
Gemmati, D.; Ongaro, A.; Tognazzo, S.; Catozzi, L.; Federici, F.; Mauro, E.; Della Porta, M.; Campioni, D.; Bardi, A.; Gilli, G.; Pellati, A.; Caruso, A.; Scapoli, G.L.; De Mattei, M.
Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkins lymphoma patients: association with toxicity and survival
Haematologica
92
478-485
2007
Homo sapiens
Manually annotated by BRENDA team
Rios, D.L.; DOnofrio, L.O.; Carvalho, H.G.; Santos-Filho, A.; Galvao-Castro, B.
Sex-specific effect of the thermolabile C677T mutation in the methylenetetrahydrofolate reductase gene on angiographically assessed coronary artery disease in Brazilians
Hum. Biol.
79
453-461
2007
Homo sapiens
Manually annotated by BRENDA team
Rassoul, F.; Richter, V.; Hentschel, B.; Geisel, J.; Herrmann, W.; Kuntze, T.
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity
Indian J. Med. Res.
127
154-158
2008
Homo sapiens
Manually annotated by BRENDA team
Cakir, O.; Ayyildiz, O.; Goz, M.; Sit, D.; Eren, N.
Myocardial infarction and venous thrombosis in a 42-year old woman with heterozygous methylenetetrahydrofolate reductase (MTHRF) gene mutation, hyperhomocysteinemia, and protein C deficiency
Int. J. Cardiol.
117
e98-100
2007
Homo sapiens
Manually annotated by BRENDA team
Kim, J.M.; Stewart, R.; Kim, S.W.; Yang, S.J.; Shin, I.S.; Shin, H.Y.; Yoon, J.S.
Methylenetetrahydrofolate reductase gene and risk of Alzheimers disease in Koreans
Int. J. Geriatr. Psychiatry
23
454-459
2008
Homo sapiens
Manually annotated by BRENDA team
Sugimoto, K.; Murata, M.; Onizuka, M.; Inamoto, Y.; Terakura, S.; Kuwatsuka, Y.; Oba, T.; Miyamura, K.; Kodera, Y.; Naoe, T.
Decreased risk of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with the 5,10-methylenetetrahydrofolate reductase 677TT genotype
Int. J. Hematol.
87
451-458
2008
Homo sapiens
Manually annotated by BRENDA team
Boettiger, A.K.; Hurtig-Wennloef, A.; Sjoestroem, M.; Yngve, A.; Nilsson, T.K.
Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents
Int. J. Mol. Med.
19
659-665
2007
Homo sapiens
Manually annotated by BRENDA team
Arai, H.; Yamamoto, A.; Matsuzawa, Y.; Saito, Y.; Yamada, N.; Oikawa, S.; Mabuchi, H.; Teramoto, T.; Sasaki, J.; Nakaya, N.; Itakura, H.; Ishikawa, Y.; Ouchi, Y.; Horibe, H.; Egashira, T.; Hattori, H.; Kita, T.
Polymorphisms of apolipoprotein E and methylenetetrahydrofolate reductase in the Japanese population
J. Artheroscler. Thromb.
14
167-171
2007
Homo sapiens
Manually annotated by BRENDA team
Leclerc, D.; Rozen, R.
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer
J. Biol. Chem.
283
3151-3160
2008
Mus musculus
Manually annotated by BRENDA team
Bennouar, N.; Allami, A.; Azeddoug, H.; Bendris, A.; Laraqui, A.; El Jaffali, A.; El Kadiri, N.; Benzidia, R.; Benomar, A.; Fellat, S.; Benomar, M.
Thermolabile methylenetetrahydrofolate reductase C677T polymorphism and homocysteine are risk factors for coronary artery disease in Moroccan population
J. Biomed. Biotechnol.
2007
80687
2007
Homo sapiens
Manually annotated by BRENDA team
Steer, C.; Emmett, P.; Lewis, S.; Smith, G.D.; Tobias, J.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in nine-year-old children
J. Bone Miner. Res.
24
117-124
2008
Homo sapiens
Manually annotated by BRENDA team
Roy, M.; Leclerc, D.; Wu, Q.; Gupta, S.; Kruger, W.D.; Rozen, R.
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency
J. Cell. Biochem.
105
467-476
2008
Mus musculus
Manually annotated by BRENDA team
Aygun, C.; Tanyeri, B.; Ceyhan, M.; Bagci, H.; Kucukoduk, S.
Diffuse multicystic encephalomalacia in a preterm baby due to homozygous methylenetetrahydrofolate reductase 677 C->T mutation
J. Child Neurol.
23
695-698
2008
Homo sapiens
Manually annotated by BRENDA team
Holm, P.I.; Hustad, S.; Ueland, P.M.; Vollset, S.E.; Grotmol, T.; Schneede, J.
Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological study
J. Clin. Endocrinol. Metab.
92
1535-1541
2007
Homo sapiens
Manually annotated by BRENDA team
Nishio, K.; Goto, Y.; Kondo, T.; Ito, S.; Ishida, Y.; Kawai, S.; Naito, M.; Wakai, K.; Hamajima, N.
Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake
J. Epidemiol.
18
125-131
2008
Homo sapiens
Manually annotated by BRENDA team
Bathum, L.; von Bornemann Hjelmborg, J.; Christiansen, L.; McGue, M.; Jeune, B.; Christensen, K.
Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians
J. Gerontol. A Biol. Sci. Med. Sci.
62
196-201
2007
Homo sapiens
Manually annotated by BRENDA team
Bronowicki, J.P.; Abdelmouttaleb, I.; Peyrin-Biroulet, L.; Venard, V.; Khiri, H.; Chabi, N.; Amouzou, E.K.; Barraud, H.; Halfon, P.; Sanni, A.; Bigard, M.A.; Le Faou, A.; Gueant, J.L.
Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa
J. Hepatol.
48
532-539
2008
Homo sapiens
Manually annotated by BRENDA team
Zintzaras, E.; Uhlig, K.; Koukoulis, G.N.; Papathanasiou, A.A.; Stefanidis, I.
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
J. Hum. Genet.
52
881-890
2007
Homo sapiens
Manually annotated by BRENDA team
Mao, R.; Fan, Y.; Jin, Y.; Bai, J.; Fu, S.
Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis
J. Hum. Genet.
53
340-348
2008
Homo sapiens
Manually annotated by BRENDA team
Li, D.; Karp, N.; Wu, Q.; Wang, X.L.; Melnyk, S.; James, S.J.; Rozen, R.
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency
J. Inherit. Metab. Dis.
31
403-411
2008
Homo sapiens
Manually annotated by BRENDA team
Agarwal, R.P.; Peters, S.M.; Shemirani, M.; von Ahsen, N.
Improved real-time multiplex polymerase chain reaction detection of methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C polymorphisms using nearest neighbor model-based probe design
J. Mol. Diagn.
9
345-350
2007
Homo sapiens (P42898)
Manually annotated by BRENDA team
Li, S.; Ji, M.; He, N.; Lu, Z.
Application of microarray-based method for methylenetetrahydrofolate reductase (MTHFR) polymorphisms in the risk of gastric carcinoma in east China population
J. Nanosci. Nanotechnol.
7
3245-3249
2007
Homo sapiens
Manually annotated by BRENDA team
Pradhan, M.; Behari, S.; Kalra, S.K.; Ojha, P.; Agarwal, S.; Jain, V.K.
Association of methylenetetrahydrofolate reductase genetic polymorphisms with atlantoaxial dislocation
J. Neurosurg. Spine
7
623-630
2007
Homo sapiens
Manually annotated by BRENDA team
Solis, C.; Veenema, K.; Ivanov, A.A.; Tran, S.; Li, R.; Wang, W.; Moriarty, D.J.; Maletz, C.V.; Caudill, M.A.
Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype
J. Nutr.
138
67-72
2008
Homo sapiens
Manually annotated by BRENDA team
Smulders, Y.M.; Smith, D.E.; Kok, R.M.; Teerlink, T.; Gellekink, H.; Vaes, W.H.; Stehouwer, C.D.; Jakobs, C.
Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status
J. Nutr. Biochem.
18
693-699
2007
Homo sapiens
Manually annotated by BRENDA team
Kawamoto, R.; Kohara, K.; Oka, Y.; Tomita, H.; Tabara, Y.; Miki, T.
An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and ischemic stroke
J. Stroke Cerebrovasc. Dis.
14
67-74
2007
Homo sapiens
Manually annotated by BRENDA team
Ghaedi, M.; Aleyasin, A.; Boroumand, M.A.; Abbasi, S.H.; Davoodi, S.; Mirakhori, M.
Common polymorphism A1298C in methylenetetrahydrofolate reductase gene is not a risk factor for coronary artery disease in selected Iranian patients
J. Tehran Univ. Heart Cent.
2
161-166
2007
Homo sapiens
-
Manually annotated by BRENDA team
Sabino, A.; Fernandes, A.P.; Lima, L.M.; Ribeiro, D.D.; Sousa, M.O.; de Castro Santos, M.E.; Mota, A.P.; Dusse, L.M.; das Gracas Carvalho, M.
Polymorphism in the methylenetetrahydrofolate reductase (C677T) gene and homocysteine levels: a comparison in Brazilian patients with coronary arterial disease, ischemic stroke and peripheral arterial obstructive disease
J. Thromb. Thrombolysis
27
82-87
2009
Homo sapiens
Manually annotated by BRENDA team
Patti, G.; Fossati, C.; Nusca, A.; Mega, S.; Pasceri, V.; DAmbrosio, A.; Giannetti, B.; Annibali, O.; Avvisati, G.; Di Sciascio, G.
Methylenetetrahydrofolate reductase (MTHFR) C677T genetic polymorphism and late infarct-related coronary artery patency after thrombolysis
J. Thromb. Thrombolysis
27
413-420
2008
Homo sapiens
Manually annotated by BRENDA team
Fukino, K.; Kawashima, T.; Suzuki, M.; Ueno, K.
Methylenetetrahydrofolate reductase and reduced folate carrier-1 genotypes and methotrexate serum concentrations in patients with rheumatoid arthritis
J. Toxicol. Sci.
32
449-452
2007
Homo sapiens
Manually annotated by BRENDA team
Chiang, E.P.; Wang, Y.C.; Tang, F.Y.
Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts
Leukemia
21
651-658
2007
Homo sapiens
Manually annotated by BRENDA team
Toniutto, P.; Fabris, C.; Falleti, E.; Cussigh, A.; Fontanini, E.; Bitetto, D.; Fornasiere, E.; Minisini, R.; De Feo, T.; Marangoni, F.; Pirisi, M.
Methylenetetrahydrofolate reductase C677T polymorphism and liver fibrosis progression in patients with recurrent hepatitis C
Liver Int.
28
257-263
2008
Homo sapiens
Manually annotated by BRENDA team
Strauss, K.A.; Morton, D.H.; Puffenberger, E.G.; Hendrickson, C.; Robinson, D.L.; Wagner, C.; Stabler, S.P.; Allen, R.H.; Chwatko, G.; Jakubowski, H.; Niculescu, M.D.; Mudd, S.H.
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency
Mol. Genet. Metab.
91
165-175
2007
Homo sapiens
Manually annotated by BRENDA team
Munoz, J.B.; Lacasana, M.; Cavazos, R.G.; Borja-Aburto, V.H.; Galaviz-Hernandez, C.; Garduno, C.A.
Methylenetetrahydrofolate reductase gene polymorphisms and the risk of anencephaly in Mexico
Mol. Hum. Reprod.
13
419-424
2007
Homo sapiens
Manually annotated by BRENDA team
Kasap, M.; Sazci, A.; Ergul, E.; Akpinar, G.
Molecular phylogenetic analysis of methylenetetrahydrofolate reductase family of proteins
Mol. Phylogenet. Evol.
42
838-846
2007
Bordetella parapertussis, Escherichia coli, Fusarium graminearum, Macaca mulatta, Pyricularia grisea, Rattus norvegicus, Brucella suis (A0A0H3G3R1), Bordetella bronchiseptica (A0A0H3LLF9), Aquifex aeolicus (O67422), Arabidopsis thaliana (O80585), Homo sapiens (P42898), Saccharomyces cerevisiae (P53128), Shigella flexneri (Q0SY49), Schizosaccharomyces pombe (Q10258), Oryza sativa (Q10BJ7), Caenorhabditis elegans (Q17693), Aspergillus oryzae (Q2UEQ8), Tetraodon nigroviridis (Q4T956), Dictyostelium discoideum (Q54X84), Candida albicans (Q5AEI0), Aspergillus nidulans (Q5B0P7), Bos taurus (Q5I598), Macaca fascicularis (Q60HE5), [Candida] glabrata (Q6FU20), Collimonas fungivorans (Q6J6A1), Rhodopseudomonas palustris (Q6N3J2), Corynebacterium diphtheriae (Q6NGB6), Desulfovibrio vulgaris (Q72DD2), Thermus thermophilus (Q72H39), Agrobacterium tumefaciens (Q7CXU3), Wolinella succinogenes (Q7M8S8), Vibrio vulnificus (Q7MH66), Photorhabdus luminescens (Q7MYD0), Gloeobacter violaceus (Q7NMH7), Chromobacterium violaceum (Q7NZF6), Rhodopirellula baltica (Q7UNJ7), Prochlorococcus marinus (Q7VE38), Candidatus Blochmannia floridanus (Q7VRL4), Xenopus laevis (Q7ZWU2), Coxiella burnetii (Q83A63), Vibrio parahaemolyticus (Q87L52), Pseudomonas syringae (Q87V72), Bradyrhizobium japonicum (Q89UJ7), Bacteroides thetaiotaomicron (Q8A146), Streptococcus pneumoniae (Q8DQT1), Bifidobacterium longum (Q8G652), Corynebacterium glutamicum (Q8NNM2), Methanosarcina mazei (Q8PZQ4), Ralstonia solanacearum (Q8Y389), Sinorhizobium meliloti (Q92NK1), Mesorhizobium loti (Q98K87), Caulobacter vibrioides (Q9A6F4), Pasteurella multocida (Q9CP31), Vibrio cholerae (Q9KNP6), Leptospira interrogans (Q9L5C1), Xylella fastidiosa (Q9PEA7), Zea mays (Q9SE94), Mus musculus (Q9WU20)
Manually annotated by BRENDA team
Michael, S.; Qamar, R.; Akhtar, F.; Khan, W.A.; Ahmed, A.
C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma
Mol. Vis.
14
661-665
2008
Homo sapiens
Manually annotated by BRENDA team
Kim, D.H.
The interactive effect of methyl-group diet and polymorphism of methylenetetrahydrofolate reductase on the risk of colorectal cancer
Mutat. Res.
622
14-18
2007
Homo sapiens
Manually annotated by BRENDA team
Linnebank, M.; Semmler, A.; Moskau, S.; Smulders, Y.; Blom, H.; Simon, M.
The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiforme
Neuro-oncology
10
548-552
2008
Homo sapiens
Manually annotated by BRENDA team
Dutta, S.; Das Bhowmik, A.; Sinha, S.; Chattopadhyay, A.; Mukhopadhyay, K.
Screening for methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Indian patients with idiopathic mental retardation
Nutr. Neurosci.
11
18-24
2008
Homo sapiens
Manually annotated by BRENDA team
Stonek, F.; Hafner, E.; Philipp, K.; Hefler, L.A.; Bentz, E.K.; Tempfer, C.B.
Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications
Obstet. Gynecol.
110
363-368
2007
Homo sapiens
Manually annotated by BRENDA team
Zetterberg, M.; Tasa, G.; Palmer, M.S.; Juronen, E.; Toover, E.; Blennow, K.; Zetterberg, H.
Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma
Ophthalmic Genet.
28
47-50
2007
Homo sapiens
Manually annotated by BRENDA team
Alcasabas, P.; Ravindranath, Y.; Goyette, G.; Haller, A.; Del Rosario, L.; Lesaca-Medina, M.Y.; Darga, L.; Ostrea, E.M.; Taub, J.W.; Everson, R.B.
5,10-Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children
Pediatr. Blood Cancer
51
178-182
2008
Homo sapiens
Manually annotated by BRENDA team
Koo, H.S.; Lee, H.S.; Hong, Y.M.
Methylenetetrahydrofolate reductase TT genotype as a predictor of cardiovascular risk in hypertensive adolescents
Pediatr. Cardiol.
29
136-141
2008
Homo sapiens
Manually annotated by BRENDA team
Bueyuekcelik, M.; Karakoek, M.; Baspinar, O.; Balat, A.
Arterial thrombosis associated with factor V Leiden and methylenetetrahydrofolate reductase C677T mutation in childhood membranous glomerulonephritis
Pediatr. Nephrol.
23
491-494
2008
Homo sapiens
Manually annotated by BRENDA team
Celtikci, B.; Leclerc, D.; Lawrance, A.K.; Deng, L.; Friedman, H.C.; Krupenko, N.I.; Krupenko, S.A.; Melnyk, S.; James, S.J.; Peterson, A.C.; Rozen, R.
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice
Pharmacogenet. Genomics
18
577-589
2008
Mus musculus
Manually annotated by BRENDA team
Etienne-Grimaldi, M.C.; Francoual, M.; Formento, J.L.; Milano, G.
Methylenetetrahydrofolate reductase (MTHFR) variants and fluorouracil-based treatments in colorectal cancer
Pharmacogenomics
8
1561-1566
2007
Homo sapiens
Manually annotated by BRENDA team
Wintner, S.; Hafner, E.; Stonek, F.; Stuempflen, I.; Metzenbauer, M.; Philipp, K.
Association of congenital cardiac defects and the C677T methylenetetrahydrofolate reductase polymorphism
Prenat. Diagn.
27
704-708
2007
Homo sapiens
Manually annotated by BRENDA team
Ozbek, Z.; Kucukali, C.I.; Ozkok, E.; Orhan, N.; Aydin, M.; Kilic, G.; Sazci, A.; Kara, I.
Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives
Prog. Neuropsychopharmacol. Biol. Psychiatry
32
1331-1337
2008
Homo sapiens
Manually annotated by BRENDA team
Vurucu, S.; Demirkaya, E.; Kul, M.; Unay, B.; Gul, D.; Akin, R.; Gokcay, E.
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy
Prog. Neuropsychopharmacol. Biol. Psychiatry
32
844-848
2008
Homo sapiens
Manually annotated by BRENDA team
Guerzoni, A.R.; Pavarino-Bertelli, E.C.; Godoy, M.F.; Graca, C.R.; Biselli, P.M.; Souza, D.R.; Bertollo, E.M.
Methylenetetrahydrofolate reductase gene polymorphism and its association with coronary artery disease
Sao Paulo Med. J.
125
4-8
2007
Homo sapiens
Manually annotated by BRENDA team
Roffman, J.L.; Weiss, A.P.; Deckersbach, T.; Freudenreich, O.; Henderson, D.C.; Purcell, S.; Wong, D.H.; Halsted, C.H.; Goff, D.C.
Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia
Schizophr. Res.
92
181-188
2007
Homo sapiens
Manually annotated by BRENDA team
Berge, E.; Haug, K.B.; Sandset, E.C.; Haugbro, K.K.; Turkovic, M.; Sandset, P.M.
The factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation
Stroke
38
1069-1071
2007
Homo sapiens
Manually annotated by BRENDA team
Garcia-Pinilla, J.M.; Espinosa-Caliani, S.; Jimenez-Navarro, M.; Gomez-Doblas, J.J.; Cabrera-Bueno, F.; Reyes-Engel, A.; de Teresa-Galvan, E.
Influence of 677 C->T polymorphism of methylenetetrahydrofolate reductase on medium-term prognosis after acute coronary syndromes
Tex. Heart Inst. J.
34
142-147
2007
Homo sapiens
Manually annotated by BRENDA team
Altomare, I.; Adler, A.; Aledort, L.M.
The 5, 10 methylenetetrahydrofolate reductase C677T mutation and risk of fetal loss: a case series and review of the literature
Thromb. J.
5
17
2007
Homo sapiens
Manually annotated by BRENDA team
Freitas, A.I.; Mendonca, I.; Guerra, G.; Brion, M.; Reis, R.P.; Carracedo, A.; Brehm, A.
Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal)
Thromb. Res.
122
648-656
2008
Homo sapiens
Manually annotated by BRENDA team
de Alvarenga, M.P.; Pavarino-Bertelli, E.C.; Abbud-Filho, M.; Ferreira-Baptista, M.A.; Haddad, R.; Eberlin, M.N.; Goloni-Bertollo, E.M.
Combination of angiotensin-converting enzyme and methylenetetrahydrofolate reductase gene polymorphisms as determinant risk factors for chronic allograft dysfunction
Transplant. Proc.
39
78-80
2007
Homo sapiens
Manually annotated by BRENDA team
Nieminen, T.; Knuuti, J.; Haemelahti, P.; Kaehoenen, M.; Laaksonen, R.; Janatuinen, T.; Vesalainen, R.; Nuutila, P.; Jokela, H.; Lehtimaeki, T.
Coronary reactivity, homocysteine and methylenetetrahydrofolate reductase gene variation in young men during pravastatin therapy
Vascul. Pharmacol.
47
113-117
2007
Homo sapiens
Manually annotated by BRENDA team
Mokarram, P.; Naghibalhossaini, F.; Saberi Firoozi, M.; Hosseini, S.V.; Izadpanah, A.; Salahi, H.; Malek-Hosseini, S.A.; Talei, A.; Mojallal, M.
Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B(12) status
World J. Gastroenterol.
14
3662-3671
2008
Homo sapiens
Manually annotated by BRENDA team
Kim, O.J.; Hong, S.P.; Ahn, J.Y.; Hong, S.H.; Hwang, T.S.; Kim, S.O.; Yoo, W.; Oh, D.; Kim, N.K.
Influence of combined methionine synthase (MTR 2756A > G) and methylenetetrahydrofolate reductase (MTHFR 677C > T) polymorphisms to plasma homocysteine levels in Korean patients with ischemic stroke
Yonsei Med. J.
48
201-209
2007
Homo sapiens
Manually annotated by BRENDA team
Guerreiro, C.S.; Carmona, B.; Goncalves, S.; Carolino, E.; Fidalgo, P.; Brito, M.; Leitao, C.N.; Cravo, M.
Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients
Am. J. Clin. Nutr.
88
1413-1418
2008
Homo sapiens
Manually annotated by BRENDA team
Lee, M.N.; Takawira, D.; Nikolova, A.P.; Ballou, D.P.; Furtado, V.C.; Phung, N.L.; Still, B.R.; Thorstad, M.K.; Tanner, J.J.; Trimmer, E.E.
Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli
Biochemistry
48
7673-7685
2009
Escherichia coli (P0AEZ1)
Manually annotated by BRENDA team
Pickell, L.; Li, D.; Brown, K.; Mikael, L.G.; Wang, X.L.; Wu, Q.; Luo, L.; Jerome-Majewska, L.; Rozen, R.
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice
Birth Defects Res. Part A Clin. Mol. Teratol.
85
531-541
2009
Mus musculus
Manually annotated by BRENDA team
Szamosi, S.; Csiki, Z.; Szomjak, E.; Szolnoki, E.; Szoke, G.; Szekanecz, Z.; Szegedi, G.; Shoenfeld, Y.; Szucs, G.
Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis: risk factors for accelerated macrovascular damage?
Clin. Rev. Allergy Immunol.
36
145-149
2009
Homo sapiens
Manually annotated by BRENDA team
Jakubowski, H.; Perla-Kajan, J.; Finnell, R.H.; Cabrera, R.M.; Wang, H.; Gupta, S.; Kruger, W.D.; Kraus, J.P.; Shih, D.M.
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice
FASEB J.
23
1721-1727
2009
Homo sapiens
Manually annotated by BRENDA team
Gilfix, B.M.
An unusual melting curve on a LightCycler due to a new mutation in methylenetetrahydrofolate reductase
Genet. Test. Mol. Biomarkers
13
769-771
2009
Homo sapiens
Manually annotated by BRENDA team
Lawrance, A.K.; Deng, L.; Rozen, R.
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice
Gut
58
805-811
2009
Mus musculus
Manually annotated by BRENDA team
Yuan, R.Y.; Sheu, J.J.; Yu, J.M.; Hu, C.J.; Tseng, I.J.; Ho, C.S.; Yeh, C.Y.; Hung, Y.L.; Chiang, T.R.
Methylenetetrahydrofolate reductase polymorphisms and plasma homocysteine in levodopa-treated and non-treated Parkinsons disease patients
J. Neurol. Sci.
287
64-68
2009
Homo sapiens
Manually annotated by BRENDA team
Fisher, M.C.; Cronstein, B.N.
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity
J. Rheumatol.
36
539-545
2009
Homo sapiens
Manually annotated by BRENDA team
Almawi, W.; Khan, A.; Al-Othman, S.; Bakhiet, M.
Case-control study of methylenetetrahydrofolate reductase mutations and hyperhomocysteinemia and risk of stroke
J. Stroke Cerebrovasc. Dis.
18
407-408
2009
Homo sapiens
Manually annotated by BRENDA team
Karas Kuzelicki, N.; Milek, M.; Jazbec, J.; Mlinaric-Rascan, I.
5,10-Methylenetetrahydrofolate reductase (MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL)
Leuk. Res.
33
1344-1348
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, Z.; Liu, Y.; Zhang, D.; Liu, Z.; Wang, P.; Zhou, D.; Zhao, T.; Wang, T.; Xu, H.; Li, S.; Feng, G.; He, L.; Yu, L.
C677T methylenetetrahydrofolate reductase gene polymorphisms in bipolar disorder: an association study in the Chinese population and a meta-analysis of genetic association studies
Neurosci. Lett.
449
48-51
2009
Homo sapiens
Manually annotated by BRENDA team
McGuire, J.J.; Haile, W.H.
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-D,L-4-methyleneglutamic acid (CH-1504) and its analogs
Biochem. Pharmacol.
77
1161-1172
2009
Homo sapiens
Manually annotated by BRENDA team
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
J. Nutr.
139
1292-1297
2009
Sus scrofa
Manually annotated by BRENDA team
Fernandez-Peralta, A.M.; Daimiel, L.; Nejda, N.; Iglesias, D.; Medina Arana, V.; Gonzalez-Aguilera, J.J.
Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy
Int. J. Colorectal Dis.
25
141-151
2010
Homo sapiens
Manually annotated by BRENDA team
Forges, T.; Chery, C.; Audonnet, S.; Feillet, F.; Gueant, J.L.
Life-threatening methylenetetrahydrofolate reductase (MTHFR) deficiency with extremely early onset: characterization of two novel mutations in compound heterozygous patients
Mol. Genet. Metab.
100
143-148
2010
Homo sapiens
Manually annotated by BRENDA team
Trimmer, E.
Methylenetetrahydrofolate reductase: Biochemical characterization and medical significance
Curr. Pharm. Des.
19
2574-2593
2013
Homo sapiens
Manually annotated by BRENDA team
Frandsen, R.J.; Albertsen, K.S.; Stougaard, P.; Sorensen, J.L.; Nielsen, K.F.; Olsson, S.; Giese, H.
Methylenetetrahydrofolate reductase activity is involved in the plasma membrane redox system required for pigment biosynthesis in filamentous fungi
Eukaryot. Cell
9
1225-1235
2010
Aspergillus nidulans, Fusarium graminearum, Aspergillus nidulans W-12, Fusarium graminearum PH-1
Manually annotated by BRENDA team
Yu, L.; Xu, J.; Liu, L.; Bian, X.; Liu, Y.
Purification and catalytic properties of methylenetetrahydrofolate reductase
Pharm. Biotechnol.
18
300-303+307
2011
Sus scrofa
-
Manually annotated by BRENDA team
Igari, S.; Ohtaki, A.; Yamanaka, Y.; Sato, Y.; Yohda, M.; Odaka, M.; Noguchi, K.; Yamada, K.
Properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8
PLoS ONE
6
e23716
2011
Thermus thermophilus (Q5SLG6), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SLG6)
Manually annotated by BRENDA team
Villela, M.P.; Andrade, V.L.; Eccard, B.; Jordao, A.A.; Sertorio, J.T.; Tanus-Santos, J.E.; Silva, I.F.; Silveira, J.N.; Sandrim, V.C.
Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin
Clin. Exp. Pharmacol. Physiol.
41
744-747
2014
Homo sapiens (P42898)
Manually annotated by BRENDA team
Bezerra, G.A.; Holenstein, A.; Foster, W.R.; Xie, B.; Hicks, K.G.; Buerer, C.; Lutz, S.; Mukherjee, A.; Sarkar, D.; Bhattacharya, D.; Rutter, J.; Talukdar, A.; Brown, P.J.; Luo, M.; Shi, L.; Froese, D.S.; Yue, W.W.
Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain
Biochimie
183
100-107
2021
Homo sapiens (P42898)
Manually annotated by BRENDA team
Froese, D.; Kopec, J.; Rembeza, E.; Bezerra, G.; Oberholzer, A.; Suormala, T.; Lutz, S.; Chalk, R.; Borkowska, O.; Baumgartner, M.; Yue, W.
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
Nat. Commun.
9
2261
2018
Homo sapiens (P42898)
Manually annotated by BRENDA team
Oeppinger, C.; Kremp, F.; Mueller, V.
Is reduced ferredoxin the physiological electron donor for MetVF-type methylenetetrahydrofolate reductases in acetogenesis? A hypothesis
Int. Microbiol.
25
7588
2022
Clostridium ljungdahlii (A0A162J7F3), Clostridium ljungdahlii DSM 13528 (A0A162J7F3)
Manually annotated by BRENDA team