Reference on EC 1.5.1.10 - saccharopine dehydrogenase (NADP+, L-glutamate-forming)
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ye, Z.H.; Bhattacharjee, J.K.
Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe
J. Bacteriol.
170
5968-5970
1988
Schizosaccharomyces pombe
Naranjo, L.; Martin de Valmaseda, E.; Banuelos, O.; Lopez, P.; Riano, J.; Casqueiro, J.; Martin, J.F.
Conversion of pipecolic acid into lysine in Penicillium chrysogenum requires pipecolate oxidase and saccharopine reductase: characterization of the lys7 gene encoding saccharopine reductase
J. Bacteriol.
183
7165-7172
2001
BRENDA: Penicillium chrysogenum (Q96TW2), Penicillium chrysogenum
Textmining: Schizosaccharomyces pombe, Saccharomyces cerevisiae, Neurospora crassa, Pyricularia grisea, Transformation, Fungi
Mukhopadhyay, A.; Mungre, S.M.; Desmukh, D.R.
Comparison of lysine and tryptophan catabolizing enzymes in rat and bovine tissues
Experientia
46
874-876
1990
Bos taurus, Rattus norvegicus
Schmidt, H.; Bode, R.; Birnbaum, D.
Regulation of the lysine biosynthesis in Pichia guilliermondii
Antonie van Leeuwenhoek
56
337-347
1989
BRENDA: Meyerozyma guilliermondii
Textmining: Saccharomyces cerevisiae
Broquist, H.P.
Aminoadipic semialdehyde-glutamate reductase
Methods Enzymol.
17B
121-124
1971
Saccharomyces cerevisiae
-
Jones, E.E.; Broquist, H.P.
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase
J. Biol. Chem.
241
3430-3434
1966
Saccharomyces cerevisiae
Storts, D.R.; Bhattacharjee, J.K.
Purification and properties of saccharopine dehydrogenase (glutamate forming) in the Saccharomyces cerevisiae lysine biosynthetic pathway
J. Bacteriol.
169
416-418
1987
Saccharomyces cerevisiae
Kinzel, J.J.; Bhattacharjee, J.K.
Role of pipecolic acid in the biosynthesis of lysine in Rhodotorula glutinis
J. Bacteriol.
138
410-417
1979
Rhodotorula glutinis
Johansson, E.; Steffens, J.J.; Emptage, M.; Lindqvist, Y.; Schneider, G.
Cloning, expression, purification and crystallization of saccharopine reductase from Magnaporthe grisea
Acta Crystallogr. Sect. D
56
662-664
2000
Pyricularia grisea
-
Garrad, R.C.; Bhattacharjee, J.K.
Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans
J. Bacteriol.
174
7379-7384
1992
Saccharomyces cerevisiae, Cryptococcus neoformans, Candida tropicalis
Naranjo, L.; Martin de Valmaseda, E.; Casqueiro, J.; Ullan, R.V.; Lamas-Maceiras, M.; Banuelos, O.; Martin, J.F.
Inactivation of the lys7 gene, encoding saccharopine reductase in Penicillium chrysogenum, leads to accumulation of the secondary metabolite precursors piperideine-6-carboxylic acid and pipecolic acid from alpha-aminoadipic acid
Appl. Environ. Microbiol.
70
1031-1039
2004
BRENDA: Penicillium chrysogenum
Textmining: Transformation
Kingsbury, J.M.; Yang, Z.; Ganous, T.M.; Cox, G.M.; McCusker, J.H.
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans
Eukaryot. Cell
3
752-763
2004
BRENDA: Cryptococcus neoformans (Q6RXX2), Cryptococcus neoformans
Textmining: Homo sapiens
Andi, B.; Cook, P.F.; West, A.H.
Crystal structure of the his-tagged saccharopine reductase from Saccharomyces cerevisiae at 1.7-A resolution
Cell Biochem. Biophys.
46
17-26
2006
BRENDA: Saccharomyces cerevisiae
Textmining: Melicope grisea, Pyricularia grisea
Vashishtha, A.K.; West, A.H.; Cook, P.F.
Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae
Biochemistry
47
5417-5423
2008
Saccharomyces cerevisiae
Vashishtha, A.K.; West, A.H.; Cook, P.F.
Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae
Biochemistry
48
5899-5907
2009
Saccharomyces cerevisiae
Leon-Ramirez, C.G.; Valdes-Santiago, L.; Campos-Gongora, E.; Ortiz-Castellanos, L.; Arechiga-Carvajal, E.T.; Ruiz-Herrera, J.
A molecular probe for Basidiomycota: the spermidine synthase-saccharopine dehydrogenase chimeric gene
FEMS Microbiol. Lett.
312
77-83
2010
Basidiomycota
Yoneda, K.; Fukuda, J.; Sakuraba, H.; Ohshima, T.
First crystal structure of L-lysine 6-dehydrogenase as an NAD-dependent amine dehydrogenase
J. Biol. Chem.
285
8444-8453
2010
Escherichia coli, Pyrococcus horikoshii (O59312), Pyrococcus horikoshii, archaeon
Almasi, J.; Bushnell, E.; Gauld, J.
A QM/MM-based computational investigation on the catalytic mechanism of saccharopine reductase
Molecules
16
8569-8589
2011
BRENDA: Pyricularia oryzae (Q9P4R4)
Textmining: Pyricularia grisea, Electron
Vashishtha, A.K.; West, A.H.; Cook, P.F.
Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis
Arch. Biochem. Biophys.
584
98-106
2015
Saccharomyces cerevisiae (P38999), Saccharomyces cerevisiae
Arruda, P.; Barreto, P.
Lysine catabolism through the saccharopine pathway enzymes and intermediates involved in plant responses to abiotic and biotic stress
Front. Plant Sci.
11
587
2020
Oryza sativa (A0A0K0K9B1), Zea mays (A0A3L6FCN0), Brassica napus (Q9FVF4), Arabidopsis thaliana (Q9SMZ4), Homo sapiens (Q9UDR5)
Xi, Z.; Yang, K.; Sheng, J.; Zhang, X.; Guo, J.; Meng, D.
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene with a possible role in postharvest development of the button mushroom (Agaricus bisporus)
J. Hortic. Sci. Biotechnol.
95
712-721
2020
Agaricus bisporus (D7GL19), Agaricus bisporus Sylvan A15 (D7GL19)
-
Borell, CW; Urrestarazu, LA; Bhattacharjee, JK
Two unlinked lysine genes (LYS9 and LYS14) are required for the synthesis of saccharopine reductase in Saccharomyces cerevisiae.
J Bacteriol
159
429-32
1984
Saccharomyces cerevisiae
Johansson, E; Steffens, JJ; Emptage, M; Lindqvist, Y; Schneider, G
Cloning, expression, purification and crystallization of saccharopine reductase from Magnaporthe grisea.
Acta Crystallogr D Biol Crystallogr
56 ( Pt 5)
662-4
2000
Pyricularia grisea, Escherichia coli
Johansson, E; Steffens, JJ; Lindqvist, Y; Schneider, G
Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis.
Structure Fold Des
8
1037-47
2000
Pyricularia grisea, Bacteria, plant, Cyanobacteria, Fungi
Mukherjee, S; Dawe, AL; Creamer, R
Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis.
Fungal Biol
116
902-9
2012
Alternaria oxytropis, Oxytropis, Fungi, Ascomycota, Metazoa, Transformation
Kurtz, M; Bhattacharjee, JK
Biosynthesis of lysine in Rhodotorula glutinis: role of pipecolic acid.
J Gen Microbiol
86
103-10
1975
Rhodotorula glutinis
Esmahan, C; Alvarez, E; Montenegro, E; Martin, JF
Catabolism of lysine in Penicillium chrysogenum leads to formation of 2-aminoadipic acid, a precursor of penicillin biosynthesis.
Appl Environ Microbiol
60
1705-10
1994
Penicillium chrysogenum
Xu, H; Andi, B; Qian, J; West, AH; Cook, PF
The alpha-aminoadipate pathway for lysine biosynthesis in fungi.
Cell Biochem Biophys
46
43-64
2006
Fungi
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