Disease on EC 1.4.3.3 - D-amino-acid oxidase
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Alzheimer Disease
Benzoate, a D-Amino Acid Oxidase Inhibitor, for the Treatment of Early-Phase Alzheimer Disease: A Randomized, Double-Blind, Placebo-Controlled Trial.
Alzheimer Disease
Brain Activity of Benzoate, a D-Amino Acid Oxidase Inhibitor, in Patients With Mild Cognitive Impairment in a Randomized, Double-Blind, Placebo Controlled Clinical Trial.
Alzheimer Disease
Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.
Alzheimer Disease
Precision Medicine of Sodium Benzoate for the Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD).
Alzheimer Disease
Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial.
Amyotrophic Lateral Sclerosis
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
Amyotrophic Lateral Sclerosis
Insights into the role of d-amino acid oxidase mutations in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Mechanistic insights into the loss-of-function mechanisms of rare human D-amino acid oxidase variants implicated in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.
Amyotrophic Lateral Sclerosis
Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.
Ataxia
Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801.
Bone Neoplasms
Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain.
Brain Neoplasms
Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: a cancer gene therapy strategy.
Carcinoma, Hepatocellular
Functional interactions between oxidative stress, membrane Na(+) permeability, and cell volume in rat hepatoma cells.
Carcinoma, Hepatocellular
[Distribution, after differential centrifugation, of acid hydrolases, catalase, D-amino acid oxidase and urate oxidase in various Morris hepatomas]
Cardiomyopathy, Dilated
Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction.
Cardiomyopathy, Dilated
Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.
d-amino-acid oxidase deficiency
d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats.
Dementia
A Post-hoc Study of D-Amino Acid Oxidase in Blood as an Indicator of Post-stroke Dementia.
Diabetes Mellitus, Experimental
Influence of insulin status on extra-mitochondrial oxygen metabolism in the rat.
Diabetes Mellitus, Experimental
Xanthine oxidase and D-amino-acid oxidase in fatty liver and alloxan diabetes.
Diabetic Retinopathy
Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.
Foot-and-Mouth Disease
Active protein aggregates induced by terminally attached self-assembling peptide ELK16 in Escherichia coli.
Glioblastoma
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia.
Glioblastoma
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.
Glioblastoma
Identification of DNA-binding proteins that interact with the 5'-flanking region of the human d-amino acid oxidase gene by pull-down assay coupled with two-dimensional gel electrophoresis and mass spectrometry.
Glioblastoma
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility.
Glioblastoma
Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting.
Glioblastoma
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.
Glioma
D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
Glioma
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).
Granulomatous Disease, Chronic
PEGylated D-amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite.
Heart Failure
Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress.
Hyperalgesia
Contributions of spinal D-amino acid oxidase to chronic morphine-induced hyperalgesia.
Hyperalgesia
Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived d-serine.
Hyperalgesia
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Hyperalgesia
WITHDRAWN: Spinal d-amino acid oxidase contributes to the pathogenesis of hyperalgesia in the rat formalin test.
Hyperoxaluria, Primary
Enzymological characterization of a feline analogue of primary hyperoxaluria type 2: a model for the human disease.
Hyperpigmentation
Evaluation of In Vitro Function by Subcellular Distribution of Lysosomal and Peroxisomal Protein in Saccharomyces cerevisiae.
Hypersensitivity
Benzoate and Sorbate Salts: A Systematic Review of the Potential Hazards of These Invaluable Preservatives and the Expanding Spectrum of Clinical Uses for Sodium Benzoate.
Hypersensitivity
Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat.
Hypersensitivity
Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat.
Hyperthyroidism
The effects of postnatal hyper- and hypothyroidism on the development of D-amino acid oxidase in rat cerebellum and brain stem.
Hypokinesia
Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway.
Hypothyroidism
The effects of postnatal hyper- and hypothyroidism on the development of D-amino acid oxidase in rat cerebellum and brain stem.
Infections
Protective Role of D-Amino Acid Oxidase Against Staphylococcus aureus infection.
Malnutrition
Hepatic and renal D-amino acid oxidase activities in the growing rat after ten days of protein undernutrition and refeeding.
Neoplasms
3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects.
Neoplasms
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin.
Neoplasms
D-Aminoacid oxidase and homogentisate oxygenase activities in the tumor bearing rats.
Neoplasms
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
Neoplasms
Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: a cancer gene therapy strategy.
Neoplasms
Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy.
Neoplasms
Oxidoreductase activities in normal rat liver, tumor-bearing rat liver, and hepatoma HC-252.
Neoplasms
Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase.
Neoplasms
PEG-DAAO conjugate: A promising tool for cancer therapy optimized by protein engineering.
Neoplasms
Preparation of enzymatically highly active pegylated-D-amino acid oxidase and its application to antitumor therapy.
Neoplasms
THE DETERMINATION OF THE TOTAL D-AMINO ACID CONTENT OF HUMAN TUMORS AND NORMAL TISSUES BY MEANS OF D-AMINO ACID OXIDASE.
Neoplasms
Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization.
Neoplasms
Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide.
Nervous System Diseases
Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation.
Neuralgia
Binding Residence Time through Scaled Molecular Dynamics: A Prospective Application to hDAAO Inhibitors.
Neuralgia
Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain.
Neuralgia
PHARMACODYNAMIC EFFECTS OF A D-AMINO ACID OXIDASE INHIBITOR INDICATE A SPINAL SITE OF ACTION IN RAT MODELS OF NEUROPATHIC PAIN.
Neurobehavioral Manifestations
D-amino Acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.
Neurobehavioral Manifestations
Drug discovery strategies and the preclinical development of D-amino-acid oxidase inhibitors as antipsychotic therapies.
Neurobehavioral Manifestations
Lack of Effect of Sodium Benzoate at Reported Clinical Therapeutic Concentration on d-Alanine Metabolism in Dogs.
Neurodegenerative Diseases
P219L substitution in human D-amino acid oxidase impacts the ligand binding and catalytic efficiency.
Neurodegenerative Diseases
The role of D-serine and glycine as co-agonists of NMDA receptors in motor neuron degeneration and amyotrophic lateral sclerosis (ALS).
Peroxisomal Disorders
Pipecolic acid is oxidized by renal and hepatic peroxisomes. Implications for Zellweger's cerebro-hepato-renal syndrome (CHRS).
Renal Aminoacidurias
Lack of D-amino-acid oxidase activity causes a specific renal aminoaciduria in the mouse.
Renal Insufficiency
D-Amino acids in chronic renal failure and the effects of dialysis and urinary losses.
Reperfusion Injury
Production of hydrogen sulfide from d-cysteine and its therapeutic potential.
Sarcoma 180
Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase.
Sleep Deprivation
Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat.
Spinocerebellar Ataxias
Localization of the candidate gene D-amino acid oxidase outside the refined I-cM region of spinocerebellar ataxia 2.
Staphylococcal Infections
Protective Role of D-Amino Acid Oxidase Against Staphylococcus aureus infection.
Starvation
Dynamics of D-amino acid oxidase in kidney epithelial cells under amino acid starvation.
Stomach Neoplasms
D-amino acid oxidase (DAO) rare genetic missense variant p.Pro103Leu and gastric cancer.
Tuberculosis
Knockout of MRA_1916 in Mycobacterium tuberculosis H37Ra affects its growth, biofilm formation, survival in macrophages and in mice.
Tuberculosis
The Mycobacterium tuberculosis H37Ra gene MRA_1916 causes growth defects upon down-regulation.
Urinary Bladder, Overactive
Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy.
Zellweger Syndrome
Histochemistry of peroxisomal enzyme activities: a tool in the diagnosis of Zellweger syndrome.
Zellweger Syndrome
The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases.
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