Any feedback?
Information on EC 1.4.3.2 - L-amino-acid oxidase and Organism(s) Mus musculus and UniProt Accession O09046
for references in articles please use BRENDA:EC1.4.3.2Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.4.3.2 L-amino-acid oxidaseIUBMB Comments
A flavoprotein (FAD).
Specify your search results
Word Map
- 1.4.3.2
- atrial
- appendage
-
occlusion
- fibrillation
- stroke
-
anticoagulation
-
bleeding
- venom
- snake
-
percutaneous
-
thromboembolic
-
amplatzer
-
watchman
-
transesophageal
-
echocardiography
-
amulet
- thrombus
-
has-bled
- embolism
-
cha2ds2-vasc
-
contraindication
-
periprocedural
-
non-valvular
-
device-related
- medicine
- tamponade
-
transcatheter
- bothrops
- crotalus
-
noacs
-
procedure-related
- rhodostoma
-
post-procedural
-
lariat
-
chads2
- calloselasma
-
fluoroscopy
-
transseptal
-
pre-procedural
-
cardioembolic
-
non-vitamin
- antivenoms
- atrox
- hare
- agkistrodon
- analysis
- moojeni
- synthesis
- drug development
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
laao, il4i1, l-amino-acid oxidase, l-aao, escapin, head kidney and gill, dolabellanin, l-phenylalanine oxidase, akbu-laao, m-lao, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
aromatic L-amino acid oxidase
-
-
-
-
L-amino acid oxidase
L-amino acid:O2 oxidoreductase
-
-
-
-
L-aminooxidase
-
-
-
-
LAAO
LAO
ophio-amino-acid oxidase
-
-
-
-
L-amino acid oxidase
-
-
-
-
LAAO
-
-
-
-
LAO
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
redox reaction
-
-
-
-
oxidative deamination
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
Alanine, aspartate and glutamate metabolism, Biosynthesis of secondary metabolites, Cysteine and methionine metabolism, Isoquinoline alkaloid biosynthesis, Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Tryptophan metabolism, Tyrosine metabolism, Valine, leucine and isoleucine degradation
SYSTEMATIC NAME
IUBMB Comments
L-amino-acid:oxygen oxidoreductase (deaminating)
A flavoprotein (FAD).
CAS REGISTRY NUMBER
COMMENTARY
9000-89-9
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-Pro + H2O + O2
? + NH3 + H2O2
-
less than 10% of the activity with L-Phe
-
-
?
L-tryptophan + H2O + O2
indole-3-pyruvate + NH3 + H2O2
-
about 30% of the activity with L-Phe
-
-
?
L-Tyr + H2O + O2
p-hydroxyphenylpyruvate + NH3 + H2O2
-
about 40% of the activity with L-Phe
-
-
?
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
responsible for killing bacteria in the mammary gland
-
-
?
additional information
?
-
reacts in decreasing order Phe, Met,Tyr, Cys, Leu, His, other amino acids
-
-
?
additional information
?
-
-
the enzyme has a preference for aromatic amin acids, less than 5% of the activity with L-Phe: Gln, Gly, Asn, His, Leu, Glu, Lys
-
-
?
additional information
?
-
-
mouse milk contains L-amino acid oxidase, a lactating mammary gland-specific protein, that displays antibacterial activity in vitro through the production of hydrogen peroxide from free amino acids
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
responsible for killing bacteria in the mammary gland
-
-
?
additional information
?
-
-
mouse milk contains L-amino acid oxidase, a lactating mammary gland-specific protein, that displays antibacterial activity in vitro through the production of hydrogen peroxide from free amino acids
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
compared to wild-type mice, LAO1 KO mice exhibit impaired fear learning and memory function in a passive avoidance test, coinciding with significantly reduced hippocampal acetylcholine levels, while treatment with donepezil, a reversible acetylcholine esterase inhibitor, inhibits this reduction. Knocking out LAO1 affects amino acid metabolism (mainly of phenylalanine) in the hippocampus. Phenylalanine levels are elevated in LAO1 KO mice, while phenylpyruvic acid levels are reduced. Knocking out LAO1 decreases hippocampal mRNA levels of pyruvate kinase, which is inhibited by phenylalanine
physiological function
-
the enzyme exhibits antibacterial, antiviral, and antiprotozoal effects
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). OXLA_MOUSE
630
0
70191
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sun, Y.; Nonobe, E.; Kobayashi, Y.; Kuraishi, T.; Aoki, F.; Yamamoto, K.; Sakai, S.
Characterization and expression of L-amino acid oxidase of mouse milk
J. Biol. Chem.
277
19080-19086
2002
Mus musculus (O09046)
Mason, J.M.; Naidu, M.D.; Barcia, M.; Porti, D.; Chavan, S.S.; Chu, C.C.
IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization
J. Immunol.
173
4561-4567
2004
Mus musculus
Nagaoka, K.; Aoki, F.; Hayashi, M.; Muroi, Y.; Sakurai, T.; Itoh, K.; Ikawa, M.; Okabe, M.; Imakawa, K.; Sakai, S.
L-amino acid oxidase plays a crucial role in host defense in the mammary glands
FASEB J.
23
2514-2520
2009
Mus musculus
Lukasheva, E.; Efremova, A.; Treshalina, E.; Arinbasarova, A.; Medentzev, A.; Berezov, T.
L-Amino acid oxidases: Properties and molecular mechanisms of action
Biomed. Khim.
58
372-384
2012
Lissachatina fulica, Aplysia californica, Bothrops jararaca, Bothrops moojeni, Mus musculus, Trichoderma harzianum, Macrovipera lebetina, Protobothrops jerdonii, Crotalus durissus cascavella, Bothrops alternatus, Trimeresurus stejnegeri, Bothrops pirajai, Sebastes schlegelii, Platichthys stellatus
EXTERNAL LINKS (specific for EC-Number 1.4.3.2)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
