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Reference on EC 1.4.3.13 - protein-lysine 6-oxidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Levene, C.I.; Carrington, M.J.
The inhibition of protein-lysine 6-oxidase by various lathyrogens. Evidence for two different mechanisms
Biochem. J.
232
293-296
1985
Gallus gallus
Manually annotated by BRENDA team
Rayton, J.K.; Harris, E.D.
Induction of lysyl oxidase with copper. Properties of an in vitro system
J. Biol. Chem.
254
621-626
1979
Gallus gallus
Manually annotated by BRENDA team
Stassen, F.L.H.
Properties of highly purified lysyl oxidase from embryonic chick cartilage
Biochim. Biophys. Acta
438
49-60
1976
Gallus gallus
Manually annotated by BRENDA team
Harris, E.D.; Gonnerman, W.A.; Savage, J.E.; O'Dell, B.L.
Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta
Biochim. Biophys. Acta
341
332-344
1974
Gallus gallus
Manually annotated by BRENDA team
Levene, C.I.; O'Shea, M.P.; Carrington, M.J.
Protein lysine 6-oxidase (lysyl oxidase) cofactor: methoxatin (PQQ) or pyridoxal?
Int. J. Biochem.
20
1451-1456
1988
Gallus gallus
Manually annotated by BRENDA team
Mki, J.M.; Kivirikko, K.I.
Cloning and characterization of a fourth human lysyl oxidase isoenzyme
Biochem. J.
355
381-387
2001
Homo sapiens (P58215), Homo sapiens
Manually annotated by BRENDA team
Smith-Mungo, L.I.; Kagan, H.M.
Lysyl oxidase: properties, regulation and multiple functions in biology
Matrix Biol.
16
387-398
1998
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Ovis aries, Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kuroyanagi, M.; Shimamura, E.; Kim, M.; Arakawa, N.; Fujiwara, Y.; Otsuka, M.
Effects of L-ascorbic acid on lysyl oxidase in the formation of collagen cross-links
Biosci. Biotechnol. Biochem.
66
2077-2082
2002
Bos taurus
Manually annotated by BRENDA team
Atsawasuwan, P.; Mochida, Y.; Parisuthiman, D.; Yamauchi, M.
Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells
Biochem. Biophys. Res. Commun.
327
1042-1046
2005
Mus musculus
Manually annotated by BRENDA team
Duff, A.P.; Cohen, A.E.; Ellis, P.J.; Kuchar, J.A.; Langley, D.B.; Shepard, E.M.; Dooley, D.M.; Freeman, H.C.; Guss, J.M.
The crystal structure of Pichia pastoris lysyl oxidase
Biochemistry
42
15148-15157
2003
Komagataella pastoris
Manually annotated by BRENDA team
Molnar, J.; Fong, K.S.K.; He, Q.P.; Hayashi, K.; Kim, Y.; Fong, S.F.T.; Fogelgren, B.; Molnarne Szauter, K.; Mink, M.; Csiszar, K.
Structural and functional diversity of lysyl oxidase and the LOX-like proteins
Biochim. Biophys. Acta
1647
220-224
2003
Homo sapiens, Mus musculus, Drosophila melanogaster (Q9N9Y8), Drosophila melanogaster (Q9V9X5)
Manually annotated by BRENDA team
Giampuzzi, M.; Oleggini, R.; Di Donato, A.
Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved
Biochim. Biophys. Acta
1647
245-251
2003
Homo sapiens
Manually annotated by BRENDA team
Hornstra, I.K.; Birge, S.; Starcher, B.; Bailey, A.J.; Mecham, R.P.; Shapiro, S.D.
Lysyl oxidase is required for vascular and diaphragmatic development in mice
J. Biol. Chem.
278
14387-14393
2003
Mus musculus
Manually annotated by BRENDA team
Kagan, H.M.; Li, W.
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
J. Cell. Biochem.
88
660-672
2003
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hayashi, K.; Fong, K.S.K.; Mercier, F.; Boyd, C.D.; Csiszar, K.; Hayashi, M.
Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues
J. Mol. Histol.
35
845-855
2004
Mus musculus
Manually annotated by BRENDA team
Jung, S.T.; Kim, M.S.; Seo, J.Y.; Kim, H.C.; Kim, Y.
Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies
Protein Expr. Purif.
31
240-246
2003
Homo sapiens
Manually annotated by BRENDA team
Maeki, J.M.; Sormunen, R.; Lippo, S.; Kaarteenaho-Wiik, R.; Soininen, R.; Myllyharju, J.
Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues
Am. J. Pathol.
167
927-936
2005
Mus musculus
Manually annotated by BRENDA team
Lau, Y.K.; Gobin, A.M.; West, J.L.
Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing
Ann. Biomed. Eng.
34
1239-1246
2006
Rattus norvegicus
Manually annotated by BRENDA team
Bollinger, J.A.; Brown, D.E.; Dooley, D.M.
The Formation of lysine tyrosylquinone (LTQ) is a self-processing reaction. Expression and characterization of a Drosophila lysyl oxidase
Biochemistry
44
11708-11714
2005
Drosophila melanogaster (Q9V9X5)
Manually annotated by BRENDA team
Bouez, C.; Reynaud, C.; Noblesse, E.; Thepot, A.; Gleyzal, C.; Kanitakis, J.; Perrier, E.; Damour, O.; Sommer, P.
The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model
Clin. Cancer Res.
12
1463-1469
2006
Homo sapiens
Manually annotated by BRENDA team
Cenizo, V.; Andre, V.; Reymermier, C.; Sommer, P.; Damour, O.; Perrier, E.
LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression
Exp. Dermatol.
15
574-581
2006
Homo sapiens
Manually annotated by BRENDA team
Lee, J.E.; Kim, Y.
A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity
J. Biol. Chem.
281
37282-37290
2006
Homo sapiens
Manually annotated by BRENDA team
Polgar, N.; Fogelgren, B.; Shipley, J.M.; Csiszar, K.
Lysyl oxidase interacts with hormone placental lactogen and synergistically promotes breast epithelial cell proliferation and migration
J. Biol. Chem.
282
3262-3272
2006
Homo sapiens
Manually annotated by BRENDA team
Bertini, V.; Buffoni, F.; Ignesti, G.; Picci, N.; Trombino, S.; Iemma, F.; Alfei, S.; Pocci, M.; Lucchesini, F.; De Munno, A.
Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases
J. Med. Chem.
48
664-670
2005
Sus scrofa (P45845)
Manually annotated by BRENDA team
Anderson, C.; Bartlett, S.J.; Gansner, J.M.; Wilson, D.; He, L.; Gitlin, J.D.; Kelsh, R.N.; Dowden, J.
Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis
Mol. BioSyst.
3
51-59
2007
Danio rerio
Manually annotated by BRENDA team
Zhao, Y.; Gao, S.; Chou, I.N.; Toselli, P.; Stone, P.; Li, W.
Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat fetal lung fibroblasts
Toxicol. Sci.
90
478-489
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hayashi, H.; Gotoh, N.; Ueda, Y.; Nakanishi, H.; Yoshimura, N.
Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population
Am. J. Ophthalmol.
145
582-585
2008
Homo sapiens
Manually annotated by BRENDA team
Guo, Y.; Pischon, N.; Palamakumbura, A.H.; Trackman, P.C.
Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells
Am. J. Physiol.
292
C2095-C2102
2007
Mus musculus
Manually annotated by BRENDA team
Lee, U.J.; Gustilo-Ashby, A.M.; Daneshgari, F.; Kuang, M.; Vurbic, D.; Lin, D.L.; Flask, C.A.; Li, T.; Damaser, M.S.
Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans
Am. J. Physiol. Renal Physiol.
295
F545-F555
2008
Mus musculus
Manually annotated by BRENDA team
Rodriguez, C.; Alcudia, J.F.; Martinez-Gonzalez, J.; Raposo, B.; Navarro, M.A.; Badimon, L.
Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction
Atherosclerosis
196
558-564
2008
Bos taurus, Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Hurtado, P.A.; Vora, S.; Sume, S.S.; Yang, D.; St Hilaire, C.; Guo, Y.; Palamakumbura, A.H.; Schreiber, B.M.; Ravid, K.; Trackman, P.C.
Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation
Biochem. Biophys. Res. Commun.
366
156-161
2008
Rattus norvegicus
Manually annotated by BRENDA team
Kim, D.J.; Lee, D.C.; Yang, S.J.; Lee, J.J.; Bae, E.M.; Kim, D.M.; Min, S.H.; Kim, S.J.; Kang, D.C.; Sang, B.C.; Myung, P.K.; Park, K.C.; Yeom, Y.I.
Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells
Biochem. Biophys. Res. Commun.
373
521-527
2008
Homo sapiens
Manually annotated by BRENDA team
Liu, G.; Daneshgari, F.; Li, M.; Lin, D.; Lee, U.; Li, T.; Damaser, M.S.
Bladder and urethral function in pelvic organ prolapsed lysyl oxidase like-1 knockout mice
BJU Int.
100
414-418
2007
Mus musculus
Manually annotated by BRENDA team
Buchinger, B.; Spitzer, S.; Karlic, H.; Klaushofer, K.; Varga, F.
Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin
Cancer Lett.
265
45-54
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Min, C.; Kirsch, K.H.; Zhao, Y.; Jeay, S.; Palamakumbura, A.H.; Trackman, P.C.; Sonenshein, G.E.
The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer
Cancer Res.
67
1105-1112
2007
Mus musculus
Manually annotated by BRENDA team
Wu, G.; Guo, Z.; Chang, X.; Kim, M.S.; Nagpal, J.K.; Liu, J.; Maki, J.M.; Kivirikko, K.I.; Ethier, S.P.; Trink, B.; Sidransky, D.
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer
Cancer Res.
67
4123-4129
2007
Homo sapiens
Manually annotated by BRENDA team
Wu, M.; Min, C.; Wang, X.; Yu, Z.; Kirsch, K.H.; Trackman, P.C.; Sonenshein, G.E.
Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells
Cancer Res.
67
6278-6285
2007
Mus musculus
Manually annotated by BRENDA team
Peinado, H.; Moreno-Bueno, G.; Hardisson, D.; Perez-Gomez, E.; Santos, V.; Mendiola, M.; de Diego, J.I.; Nistal, M.; Quintanilla, M.; Portillo, F.; Cano, A.
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
Cancer Res.
68
4541-4550
2008
Homo sapiens
Manually annotated by BRENDA team
Rodriguez, C.; Martinez-Gonzalez, J.; Raposo, B.; Alcudia, J.F.; Guadall, A.; Badimon, L.
Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases
Cardiovasc. Res.
79
7-13
2008
Mus musculus
Manually annotated by BRENDA team
Kuhlenbaeumer, G.; Friedrichs, F.; Kis, B.; Berlit, P.; Maintz, D.; Nassenstein, I.; Nabavi, D.; Dittrich, R.; Stoll, M.; Ringelstein, B.
Association between single nucleotide polymorphisms in the lysyl oxidase-like 1 gene and spontaneous cervical artery dissection
Cerebrovasc. Dis.
24
343-348
2007
Homo sapiens
Manually annotated by BRENDA team
Tzen, C.Y.; Huang, Y.W.; Wang, M.N.
Cloning of genes expressed in cell quiescence: a new function of the ras-recision/lysyl oxidase gene
Chin. J. Physiol.
50
57-62
2007
Mus musculus
Manually annotated by BRENDA team
Shieh, T.M.; Lin, S.C.; Liu, C.J.; Chang, S.S.; Ku, T.H.; Chang, K.W.
Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis
Clin. Cancer Res.
13
4378-4385
2007
Homo sapiens
Manually annotated by BRENDA team
Gansner, J.M.; Mendelsohn, B.A.; Hultman, K.A.; Johnson, S.L.; Gitlin, J.D.
Essential role of lysyl oxidases in notochord development
Dev. Biol.
307
202-213
2007
Danio rerio (A1L1V4), Danio rerio (A6MH29), Danio rerio (A6MH32), Danio rerio (A6MH33), Danio rerio (A6MH34), Danio rerio (A6MH35), Danio rerio (F1QQC3), Danio rerio (Q6NYT8), Danio rerio
Manually annotated by BRENDA team
Rodriguez, C.; Rodriguez-Sinovas, A.; Martinez-Gonzalez, J.
Lysyl oxidase as a potential therapeutic target
Drug News Perspect.
21
218-224
2008
Mus musculus
Manually annotated by BRENDA team
Lelievre, E.; Hinek, A.; Lupu, F.; Buquet, C.; Soncin, F.; Mattot, V.
VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases
EMBO J.
27
1658-1670
2008
Mus musculus
Manually annotated by BRENDA team
Alcudia, J.F.; Martinez-Gonzalez, J.; Guadall, A.; Gonzalez-Diez, M.; Badimon, L.; Rodriguez, C.
Lysyl oxidase and endothelial dysfunction: mechanisms of lysyl oxidase down-regulation by pro-inflammatory cytokines
Front. Biosci.
13
2721-2727
2008
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Fong, S.F.; Dietzsch, E.; Fong, K.S.; Hollosi, P.; Asuncion, L.; He, Q.; Parker, M.I.; Csiszar, K.
Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors
Genes Chromosomes Cancer
46
644-655
2007
Homo sapiens
Manually annotated by BRENDA team
Consuegra, S.; Johnston, I.A.
Effect of natural selection on the duplicated lysyl oxidase gene in Atlantic salmon
Genetica
134
325-334
2008
Salmo salar (A1X3M9), Salmo salar, Oncorhynchus mykiss (B2BHP1)
Manually annotated by BRENDA team
Akagawa, H.; Narita, A.; Yamada, H.; Tajima, A.; Krischek, B.; Kasuya, H.; Hori, T.; Kubota, M.; Saeki, N.; Hata, A.; Mizutani, T.; Inoue, I.
Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms
Hum. Genet.
121
377-387
2007
Homo sapiens
Manually annotated by BRENDA team
Hewitt, A.W.; Sharma, S.; Burdon, K.P.; Wang, J.J.; Baird, P.N.; Dimasi, D.P.; Mackey, D.A.; Mitchell, P.; Craig, J.E.
Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people
Hum. Mol. Genet.
17
710-716
2008
Homo sapiens
Manually annotated by BRENDA team
Weise, J.B.; Csiszar, K.; Gottschlich, S.; Hoffmann, M.; Schmidt, A.; Weingartz, U.; Adamzik, I.; Heiser, A.; Kabelitz, D.; Ambrosch, P.; Goeroegh, T.
Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer
Int. J. Oncol.
32
317-322
2008
Homo sapiens
Manually annotated by BRENDA team
Alperin, M.; Debes, K.; Abramowitch, S.; Meyn, L.; Moalli, P.A.
LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues
Int. Urogynecol. J. Pelvic. Floor Dysfunct.
19
977-986
2008
Mus musculus
Manually annotated by BRENDA team
Pasutto, F.; Krumbiegel, M.; Mardin, C.Y.; Paoli, D.; Laemmer, R.; Weber, B.H.; Kruse, F.E.; Schloetzer-Schrehardt, U.; Reis, A.
Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma
Invest. Ophthalmol. Vis. Sci.
49
1459-1463
2008
Homo sapiens
Manually annotated by BRENDA team
Yu, H.G.; Liu, X.; Kiss, S.; Connolly, E.; Gragoudas, E.S.; Michaud, N.A.; Bulgakov, O.V.; Adamian, M.; DeAngelis, M.M.; Miller, J.W.; Li, T.; Kim, I.K.
Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1
Invest. Ophthalmol. Vis. Sci.
49
2599-2605
2008
Mus musculus
Manually annotated by BRENDA team
Liu, Y.; Schmidt, S.; Qin, X.; Gibson, J.; Hutchins, K.; Santiago-Turla, C.; Wiggs, J.L.; Budenz, D.L.; Akafo, S.; Challa, P.; Herndon, L.W.; Hauser, M.A.; Allingham, R.R.
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations
Invest. Ophthalmol. Vis. Sci.
49
3465-3468
2008
Homo sapiens
Manually annotated by BRENDA team
Gao, S.; Zhao, Y.; Kong, L.; Toselli, P.; Chou, I.N.; Stone, P.; Li, W.
Cloning and characterization of the rat lysyl oxidase gene promoter: identification of core promoter elements and functional nuclear factor I-binding sites
J. Biol. Chem.
282
25322-25337
2007
Rattus norvegicus
Manually annotated by BRENDA team
Lucero, H.A.; Ravid, K.; Grimsby, J.L.; Rich, C.B.; Dicamillo, S.J.; Maeki, J.M.; Myllyharju, J.; Kagan, H.M.
Lysyl oxidase oxidizes cell membrane proteins and enhances the chemotactic response of vascular smooth muscle cells
J. Biol. Chem.
283
24103-24117
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Payne, S.L.; Hendrix, M.J.; Kirschmann, D.A.
Paradoxical roles for lysyl oxidases in cancer - a prospect
J. Cell. Biochem.
101
1338-1354
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Postovit, L.M.; Abbott, D.E.; Payne, S.L.; Wheaton, W.W.; Margaryan, N.V.; Sullivan, R.; Jansen, M.K.; Csiszar, K.; Hendrix, M.J.; Kirschmann, D.A.
Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration
J. Cell. Biochem.
103
1369-1378
2008
Homo sapiens
Manually annotated by BRENDA team
Goeroegh, T.; Weise, J.B.; Holtmeier, C.; Rudolph, P.; Hedderich, J.; Gottschlich, S.; Hoffmann, M.; Ambrosch, P.; Csiszar, K.
Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma
J. Pathol.
212
74-82
2007
Homo sapiens
Manually annotated by BRENDA team
Oleggini, R.; Gastaldo, N.; Di Donato, A.
Regulation of elastin promoter by lysyl oxidase and growth factors: cross control of lysyl oxidase on TGF-beta1 effects
Matrix Biol.
26
494-505
2007
Homo sapiens
Manually annotated by BRENDA team
Reynaud, C.; Baas, D.; Gleyzal, C.; Le Guellec, D.; Sommer, P.
Morpholino knockdown of lysyl oxidase impairs zebrafish development, and reflects some aspects of copper metabolism disorders
Matrix Biol.
27
547-560
2008
Danio rerio
Manually annotated by BRENDA team
Sivakumar, P.; Gupta, S.; Sarkar, S.; Sen, S.
Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy
Mol. Cell. Biochem.
307
159-167
2008
Homo sapiens
Manually annotated by BRENDA team
Mori, K.; Imai, K.; Matsuda, A.; Ikeda, Y.; Naruse, S.; Hitora-Takeshita, H.; Nakano, M.; Taniguchi, T.; Omi, N.; Tashiro, K.; Kinoshita, S.
LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population
Mol. Vis.
14
1037-1040
2008
Homo sapiens
Manually annotated by BRENDA team
Mabuchi, F.; Sakurada, Y.; Kashiwagi, K.; Yamagata, Z.; Iijima, H.; Tsukahara, S.
Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome
Mol. Vis.
14
1303-1308
2008
Homo sapiens
Manually annotated by BRENDA team
Fuse, N.; Miyazawa, A.; Nakazawa, T.; Mengkegale, M.; Otomo, T.; Nishida, K.
Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese
Mol. Vis.
14
1338-1343
2008
Homo sapiens
Manually annotated by BRENDA team
Challa, P.; Schmidt, S.; Liu, Y.; Qin, X.; Vann, R.R.; Gonzalez, P.; Allingham, R.R.; Hauser, M.A.
Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma
Mol. Vis.
14
146-149
2008
Homo sapiens
Manually annotated by BRENDA team
Aragon-Martin, J.A.; Ritch, R.; Liebmann, J.; OBrien, C.; Blaaow, K.; Mercieca, F.; Spiteri, A.; Cobb, C.J.; Damji, K.F.; Tarkkanen, A.; Rezaie, T.; Child, A.H.; Sarfarazi, M.
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
Mol. Vis.
14
533-541
2008
Homo sapiens
Manually annotated by BRENDA team
Mossboeck, G.; Renner, W.; Faschinger, C.; Schmut, O.; Wedrich, A.; Weger, M.
Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population
Mol. Vis.
14
857-861
2008
Homo sapiens
Manually annotated by BRENDA team
Laczko, R.; Szauter, K.M.; Jansen, M.K.; Hollosi, P.; Muranyi, M.; Molnar, J.; Fong, K.S.; Hinek, A.; Csiszar, K.
Active lysyl oxidase (LOX) correlates with focal adhesion kinase (FAK)/paxillin activation and migration in invasive astrocytes
Neuropathol. Appl. Neurobiol.
33
631-643
2007
Homo sapiens
Manually annotated by BRENDA team
Sakai, M.; Kato, H.; Sano, A.; Tanaka, N.; Inose, T.; Kimura, H.; Sohda, M.; Nakajima, M.; Kuwano, H.
Expression of lysyl oxidase is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma
Ann. Surg. Oncol.
16
2494-2501
2009
Homo sapiens
Manually annotated by BRENDA team
Onoda, M.; Yoshimura, K.; Aoki, H.; Ikeda, Y.; Morikage, N.; Furutani, A.; Matsuzaki, M.; Hamano, K.
Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm
Atherosclerosis
208
366-369
2009
Rattus norvegicus
Manually annotated by BRENDA team
Contente, S.; Yeh, T.J.; Friedman, R.M.
Tumor suppressive effect of lysyl oxidase proenzyme
Biochim. Biophys. Acta
1793
1272-1278
2009
Mus musculus
Manually annotated by BRENDA team
Mizobe, Y.; Oikawa, D.; Tsuyama, S.; Akimoto, Y.; Hamasu, K.; Onitsuka, E.; Sato, M.; Takahata, Y.; Morimatsu, F.; Furuse, M.
mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin
Biosci. Biotechnol. Biochem.
72
3067-3070
2008
Mus musculus
Manually annotated by BRENDA team
Erler, J.T.; Bennewith, K.L.; Cox, T.R.; Lang, G.; Bird, D.; Koong, A.; Le, Q.T.; Giaccia, A.J.
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
Cancer Cell
15
35-44
2009
Homo sapiens
Manually annotated by BRENDA team
Choudhary, B.; Zhou, J.; Li, P.; Thomas, S.; Kaartinen, V.; Sucov, H.M.
Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm
Genesis
47
115-121
2009
Mus musculus
Manually annotated by BRENDA team
Lopez, B.; Querejeta, R.; Gonzalez, A.; Beaumont, J.; Larman, M.; Diez, J.
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure
Hypertension
53
236-242
2009
Homo sapiens
Manually annotated by BRENDA team
Coral, K.; Angayarkanni, N.; Madhavan, J.; Bharathselvi, M.; Ramakrishnan, S.; Nandi, K.; Rishi, P.; Kasinathan, N.; Krishnakumar, S.
Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment
Invest. Ophthalmol. Vis. Sci.
49
4746-4752
2008
Homo sapiens
Manually annotated by BRENDA team
Atsawasuwan, P.; Mochida, Y.; Katafuchi, M.; Kaku, M.; Fong, K.S.; Csiszar, K.; Yamauchi, M.
Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity
J. Biol. Chem.
283
34229-34240
2008
Mus musculus
Manually annotated by BRENDA team
Papachroni, K.K.; Piperi, C.; Levidou, G.; Korkolopoulou, P.; Pawelczyk, L.; Diamanti-Kandarakis, E.; Papavassiliou, A.G.
Lysyl oxidase interacts with AGEs signaling to modulate collagen synthesis in polycystic ovarian tissue
J. Cell. Mol. Med.
14
2460-2469
2010
Homo sapiens
Manually annotated by BRENDA team
Shieh, T.M.; Tu, H.F.; Ku, T.H.; Chang, S.S.; Chang, K.W.; Liu, C.J.
Association between lysyl oxidase polymorphisms and oral submucous fibrosis in older male areca chewers
J. Oral Pathol. Med.
38
109-113
2009
Homo sapiens
Manually annotated by BRENDA team
Kothapalli, C.R.; Ramamurthi, A.
Lysyl oxidase enhances elastin synthesis and matrix formation by vascular smooth muscle cells
J. Tissue Eng. Regen. Med.
3
655-661
2009
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Bondareva, A.; Downey, C.M.; Ayres, F.; Liu, W.; Boyd, S.K.; Hallgrimsson, B.; Jirik, F.R.
The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells
PLoS ONE
4
e5620
2009
Homo sapiens, Homo sapiens (P28300)
Manually annotated by BRENDA team
Behmoaras, J.; Slove, S.; Seve, S.; Vranckx, R.; Sommer, P.; Jacob, M.P.
Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta
Rejuvenation Res.
11
883-889
2008
Rattus norvegicus
Manually annotated by BRENDA team
Saad, F.A.; Torres, M.; Wang, H.; Graham, L.
Intracellular lysyl oxidase: effect of a specific inhibitor on nuclear mass in proliferating cells
Biochem. Biophys. Res. Commun.
396
944-949
2010
Rattus norvegicus (P16636), Homo sapiens (P28300), Homo sapiens
Manually annotated by BRENDA team
Santhanam, A.N.; Baker, A.R.; Hegamyer, G.; Kirschmann, D.A.; Colburn, N.H.
Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion
Oncogene
29
3921-3932
2010
Homo sapiens (P28300), Homo sapiens
Manually annotated by BRENDA team
Herwald, S.E.; Greenaway, F.T.; Lopez, K.M.
Purification of high yields of catalytically active lysyl oxidase directly from Escherichia coli cell culture
Protein Expr. Purif.
74
116-121
2010
Homo sapiens
Manually annotated by BRENDA team
van Boxtel, A.L.; Kamstra, J.H.; Fluitsma, D.M.; Legler, J.
Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity
Toxicol. Appl. Pharmacol.
244
156-161
2010
Danio rerio
Manually annotated by BRENDA team
Pestov, N.B.; Okkelman, I.A.; Shmanai, V.V.; Hurski, A.L.; Giaccia, A.J.; Shchepinov, M.S.
Control of lysyl oxidase activity through site-specific deuteration of lysine
Bioorg. Med. Chem. Lett.
21
255-258
2011
Ovis aries, Mus musculus
Manually annotated by BRENDA team
Schietke, R.; Warnecke, C.; Wacker, I.; Schdel, J.; Mole, D.; Campean, V.; Amann, K.; Goppelt-Struebe, M.; Behrens, J.; Eckardt, K.; Wiesener, M.
The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: Insights into cellular transformation processes mediated by HIF-1
J. Biol. Chem.
285
6658-6669
2010
Homo sapiens
Manually annotated by BRENDA team
Xu, L.; Go, E.P.; Finney, J.; Moon, H.; Lantz, M.; Rebecchi, K.; Desaire, H.; Mure, M.
Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells
J. Biol. Chem.
288
5357-5363
2013
Homo sapiens (Q9Y4K0), Homo sapiens
Manually annotated by BRENDA team
Grimsby, J.L.; Lucero, H.A.; Trackman, P.C.; Ravid, K.; Kagan, H.M.
Role of lysyl oxidase propeptide in secretion and enzyme activity
J. Cell. Biochem.
111
1231-1243
2010
Homo sapiens (P28300)
Manually annotated by BRENDA team
Hutchinson, J.H.; Rowbottom, M.W.; Lonergan, D.; Darlington, J.; Prodanovich, P.; King, C.D.; Evans, J.F.; Bain, G.
Small molecule lysyl oxidase-like 2 (LOXL2) inhibitors the identification of an inhibitor selective for LOXL2 over LOX
ACS Med. Chem. Lett.
8
423-427
2017
Homo sapiens
Manually annotated by BRENDA team
Wiel, C.; Augert, A.; Vincent, D.F.; Gitenay, D.; Vindrieux, D.; Le Calve, B.; Arfi, V.; Lallet-Daher, H.; Reynaud, C.; Treilleux, I.; Bartholin, L.; Lelievre, E.; Bernard, D.
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis
Cell Death Dis.
4
e855
2013
Homo sapiens
Manually annotated by BRENDA team
Smith, M.A.; Gonzalez, J.; Hussain, A.; Oldfield, R.N.; Johnston, K.A.; Lopez, K.M.
Overexpression of soluble recombinant human lysyl oxidase by using solubility tags effects on activity and solubility
Enzyme Res.
2016
5098985
2016
Homo sapiens
Manually annotated by BRENDA team
Liu, S.B.; Ikenaga, N.; Peng, Z.W.; Sverdlov, D.Y.; Greenstein, A.; Smith, V.; Schuppan, D.; Popov, Y.
Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice
FASEB J.
30
1599-1609
2016
Mus musculus
Manually annotated by BRENDA team
Herchenhan, A.; Uhlenbrock, F.; Eliasson, P.; Weis, M.; Eyre, D.; Kadler, K.E.; Magnusson, S.P.; Kjaer, M.
Lysyl oxidase activity is required for ordered collagen fibrillogenesis by tendon cells
J. Biol. Chem.
290
16440-16450
2015
Homo sapiens
Manually annotated by BRENDA team
Ma, L.; Huang, C.; Wang, X.J.; Xin, D.E.; Wang, L.S.; Zou, Q.C.; Zhang, Y.S.; Tan, M.D.; Wang, Y.M.; Zhao, T.C.; Chatterjee, D.; Altura, R.A.; Wang, C.; Xu, Y.S.; Yang, J.H.; Fan, Y.S.; Han, B.H.; Si, J.; Zhang, X.; Cheng, J.; Chang, Z.; Chin, Y.E.
Lysyl oxidase 3 is a dual-specificity enzyme involved in stat3 deacetylation and deacetylimination modulation
Mol. Cell
65
296-309
2017
Mus musculus
Manually annotated by BRENDA team
Li, S.Y.; Yan, J.Q.; Song, Z.; Liu, Y.F.; Song, M.J.; Qin, J.W.; Yang, Z.M.; Liang, X.H.
Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization
FEBS Lett.
591
1394-1407
2017
Mus musculus (P28301), Mus musculus, Mus musculus CD-1 (P28301)
Manually annotated by BRENDA team
Sarabia-Sainz, H.M.; Ezquerra-Brauer, J.M.; Santacruz-Ortega, H.C.; Rouzaud-Sandez, O.; Valenzuela-Soto, E.M.; Acosta-Elias, M.; Torres-Arreola, W.
Muscle lysyl oxidase activity and structural/thermal properties of highly cross-linked collagen in jumbo squid (Dosidicus gigas) mantle, fins and arms
Food Sci. Biotechnol.
27
57-64
2018
Dosidicus gigas
Manually annotated by BRENDA team
Bhuvanasundar, R.; Ragavachetty, N.; Singh, N.; Coral, K.; Deepa, P.; Sulochana, K.
Expression, purification and characterization of a biologically active and thermally stable human lysyl oxidase
Indian J. Biochem. Biophys.
56
105-116
2019
Homo sapiens (P28300)
-
Manually annotated by BRENDA team
Saleem, A.; Rajput, S.
Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein
J. Genet. Eng. Biotechnol.
18
20
2020
Canis lupus familiaris (J9NZK5), Canis lupus familiaris
Manually annotated by BRENDA team
Pestov, N.B.; Kalinovsky, D.V.; Larionova, T.D.; Zakirova, A.Z.; Modyanov, N.N.; Okkelman, I.A.; Korneenko, T.V.
Properties of a cryptic lysyl oxidase from haloarchaeon Haloterrigena turkmenica
PeerJ
7.
e6691
2019
Haloterrigena turkmenica, Haloterrigena turkmenica VKMB-1734
Manually annotated by BRENDA team
Zhang, X.; Wang, Q.; Wu, J.; Wang, J.; Shi, Y.; Liu, M.
Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state
Proc. Natl. Acad. Sci. USA
115
3828-3833
2018
Homo sapiens (Q9Y4K0), Homo sapiens
Manually annotated by BRENDA team
De Vita, A.; Liverani, C.; Molinaro, R.; Martinez, J.O.; Hartman, K.A.; Spadazzi, C.; Miserocchi, G.; Taraballi, F.; Evangelopoulos, M.; Pieri, F.; Bongiovanni, A.; Mercatali, L.; Tasciotti, E.; Ibrahim, T.
Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer
Sci. Rep.
11
5107
2021
Homo sapiens (Q08397)
Manually annotated by BRENDA team
Kim, I.K.; Lee, Y.S.; Kim, H.S.; Dong, S.M.; Park, J.S.; Yoon, D.S.
Specific protein 1(SP1) regulates the epithelial-mesenchymal transition via lysyl oxidase-like 2(LOXL2) in pancreatic ductal adenocarcinoma
Sci. Rep.
9
5933
2019
Homo sapiens (Q9Y4K0), Homo sapiens
Manually annotated by BRENDA team