Information on EC 1.3.98.4 - 5a,11a-dehydrotetracycline reductase

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The expected taxonomic range for this enzyme is: Streptomyces aureofaciens

EC NUMBER
COMMENTARY hide
1.3.98.4
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RECOMMENDED NAME
GeneOntology No.
5a,11a-dehydrotetracycline reductase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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Biosynthesis of type II polyketide products
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tetracycline and oxytetracycline biosynthesis
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Tetracycline biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
tetracycline:coenzyme F420 dehydrogenase
The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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mixed cultivation of mutants blocked in tetracycline synthesis reveals fout types of metabolic complementation
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
7-chloro-5a,11a-dehydrotetracycline + reduced 7,8-didemethyl-8-hydroxy-5-deazariboflavin
7-chlorotetracycline + oxidized 7,8-didemethyl-8-hydroxy-5-deazariboflavin
show the reaction diagram
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7-chloro-5a,11a-dehydrotetracycline + reduced cosynthetic factor-1
7-chlorotetracycline + oxidized cosynthetic factor-1
show the reaction diagram
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tetracycline + oxidized coenzyme F420
5a,11a-dehydrotetracycline + reduced coenzyme F420
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
7-chloro-5a,11a-dehydrotetracycline + reduced 7,8-didemethyl-8-hydroxy-5-deazariboflavin
7-chlorotetracycline + oxidized 7,8-didemethyl-8-hydroxy-5-deazariboflavin
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7,8-didemethyl-8-hydroxy-5-deazariboflavin
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i.e. cosynthetic facor-1
additional information
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cosynthetic factor-1 enables Streptomyces aureofaciens to produce tetracycline instead of their 5a,11a-dehydro analogues; isolation of Cosynthetic Factor I, required for catayltic activity. The factor is dialysable and stable to autoclaving over the pH range of 1 to 10
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information