Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively . The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 . cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
vlcad, very long-chain acyl-coa dehydrogenase, long-chain acyl-coa dehydrogenase, very long chain acyl-coa dehydrogenase, long-chain acyl-coa hydrolase, long chain acyl-coa dehydrogenase, long-chain acyl-coenzyme a dehydrogenase, palmitoyl-coa dehydrogenase, acyl-coa dehydrogenase 9, very-long-chain acyl-coenzyme a dehydrogenase, more
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
LCAD enzyme activity in livers of partially deficient LCAD mice 8 weeks after injection of recombinant adeno-associated viral mLCAD vector via the hepatic portal vein
before postnatal day 10, BACH is detected at very low levelsthen, BACH content rapidly increases from postnatal day 14 and reaches maximum levels at postnatal day 21, remaining high until at least postnatal day 70
construction of null mutant mouse embryos, analysis of developmental competence, at blastocyst transition, the homozygous null mutants do not survive, while the homozygous wild-types continue the normal development, and the heterozygous embryos show an intermediate cavitation rate, addition of fatty acids complexed to albumin into the medium, the deficient embryos survive and overcome the deficiency, overview
transient and stable expression as C-terminally MYC-tagged enzyme in mouse C3H 10T1/2 fibroblastic cells using a mifepristone-inducible gene expression system, analysis of cell growth rates, enzyme expression rates, and effect on phospholipid synthesis, overview
CTE-II expression is induced during embryogenesis in association with neuronal differentiation, and persists after terminal differentiation in neurons at postnatal stages, resulting in constitutive high expression in the adult brain in a neuron-specific manner
LCAD gene replacement to the tibialis anterior muscle and livers of partially deficient LCAD mice is described, a surrogate model for human VLCAD deficiency
Primassin, S.; Ter Veld, F.; Mayatepek, E.; Spiekerkoetter, U.
Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine