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Information on EC 1.3.5.5 - 15-cis-phytoene desaturase and Organism(s) Arabidopsis thaliana and UniProt Accession Q07356

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IUBMB Comments
This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. The enzyme from Synechococcus can also use NAD+ and NADP+ as electron acceptor under anaerobic conditions. The enzyme from Gentiana lutea shows no activity with NAD+ or NADP+ .
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Arabidopsis thaliana
UNIPROT: Q07356
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
ospds, bopds, citpds1, plant-type phytoene desaturase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
15-cis-phytoene:plastoquinone oxidoreductase
This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. The enzyme from Synechococcus can also use NAD+ and NADP+ as electron acceptor under anaerobic conditions. The enzyme from Gentiana lutea shows no activity with NAD+ or NADP+ [1].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
15-cis-phytoene + acceptor
9,15,9'-tricis-zeta-carotene + reduced acceptor
show the reaction diagram
phytoene desaturase is an enzyme of the carotenoid biosynthetic pathway
-
-
?
15-cis-phytoene + 2 plastoquinone
9,15,9'-tricis-zeta-carotene + 2 plastoquinol
show the reaction diagram
-
phytoene desaturase is an early enzyme of the carotenoid biosynthetic pathway
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
15-cis-phytoene + 2 plastoquinone
9,15,9'-tricis-zeta-carotene + 2 plastoquinol
show the reaction diagram
-
phytoene desaturase is an early enzyme of the carotenoid biosynthetic pathway
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
plastoquinone
-
plastoquinone is an essential component of phytoene desaturation
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
norflorazon
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Columbia ecotype
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
both the albino and dwarf phenotypes of the pds3 mutant result from functional disruption of the PDS3 gene. Chloroplast development is arrested at the proplastid stage in the pds3 mutant. Further analysis shows that a high level of phytoene is accumulated in the pds3 mutant. Disrupting PDS3 gene results in gene expression changes involved in at least 20 metabolic pathways, including the inhibition of many genes in carotenoid, chlorophyll, and GA biosynthesis pathways. The accumulated phytoene in the pds3 mutant might play an important role in certain negative feedbacks to affect gene expression of diverse cellular pathways
physiological function
-
phytoene desaturase is an early enzyme of the carotenoid biosynthetic pathway
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PDS_ARATH
566
0
62964
Swiss-Prot
Chloroplast (Reliability: 5)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
there is no significant induction of phytoene desaturase gene expression specific to white tissue, indicating that phytoene desaturase expression is independent of the pigment status of the cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Qin, G.; Gu, H.; Ma, L.; Peng, Y.; Deng, X.W.; Chen, Z.; Qu, L.J.
Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis
Cell Res.
17
471-482
2007
Arabidopsis thaliana (Q07356)
Manually annotated by BRENDA team
Norris, S.R.; Barrette, T.R.; DellaPenna, D.
Genetic dissection of carotenoid synthesis in arabidopsis defines plastoquinone as an essential component of phytoene desaturation
Plant Cell
7
2139-2149
1995
Arabidopsis thaliana
Manually annotated by BRENDA team
Wetzel, C.M.; Rodermel, S.R.
Regulation of phytoene desaturase expression is independent of leaf pigment content in Arabidopsis thaliana
Plant Mol. Biol.
37
1045-1053
1998
Arabidopsis thaliana
Manually annotated by BRENDA team