Reference on EC 1.3.1.9 - enoyl-[acyl-carrier-protein] reductase (NADH)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shimakata, T.; Stumpf, P.K.
Purification and characterizations of beta-ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves
Arch. Biochem. Biophys.
218
77-91
1982
Spinacia oleracea
Shimakata, T.; Stumpf, P.K.
The procaryotic nature of the fatty acid synthetase of developing Carthamus tinctorius L. (Safflower) seeds
Arch. Biochem. Biophys.
217
144-154
1982
Carthamus tinctorius
Shimakata, T.; Stumpf, P.K.
Fatty acid synthetase of Spinacia oleracea leaves
Plant Physiol.
69
1257-1262
1982
Spinacia oleracea
Caughey, I.; Kekwick, R.G.O.
The characteristics of some components of the fatty acid synthetase system in the plastids from the mesocarp of avocado (Persea americana) fruit
Eur. J. Biochem.
123
553-561
1982
Persea americana
Fisher, M.; Kroon, J.T.M.; Martindale, W.; Stuitje, A.R.; Slabas, A.R.; Rafferty, J.B.
The x-ray structure of Brassica napus beta-keto acyl carrier protein reductase and its implications for substrate binding and catalysis
Structure
8
339-347
2000
Brassica napus
Saito, K.; Kawaguchi, A.; Seyama, Y.; Yamakawa, T.; Okuda, S.
Steric course of reaction catalyzed by the enoyl acyl-carrier-protein reductase of Escherichia coli
Eur. J. Biochem.
116
581-586
1981
Escherichia coli
Weeks, G.; Wakil, S.J.
Studies on the mechanism of fatty acid synthesis. 18. Preparation and general properties of the enoyl acyl carrier protein reductases from Escherichia coli
J. Biol. Chem.
243
1180-1189
1968
Escherichia coli
Saito, K.; Kawaguchi, A.; Okuda, S.; Seyama, Y.; Yamakawa, T.
Incorporation of hydrogen atoms from deuterated water and stereospecifically deuterium-labeled nicotin amide nucleotides into fatty acids with the Escherichia coli fatty acid synthetase system
Biochim. Biophys. Acta
618
202-213
1980
Escherichia coli
Bergler, H.; Fuchsbichler, S.; Hoegenauer, G.; Turnowsky, F.
The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA
Eur. J. Biochem.
242
689-694
1996
Escherichia coli
Heath, R.J.; Su, N.; Murphy, C.K.; Rock, C.O.
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis
J. Biol. Chem.
275
40128-40133
2000
Bacillus subtilis, Bacillus subtilis (P54616)
Slabas, A.R.; Cottingham, I.R.; Austin, A.; Hellyer, A.; Safford, R.; Smith, C.G.
Immunological detection of NADH-specific enoyl-ACP reductase from rape seed (Brassica napus)-induction, relationship of alpha and beta polypeptides, mRNA translation and interaction with ACP
Biochim. Biophys. Acta
1039
181-188
1990
Brassica napus
Cottingham, I.R.; Austin, A.J.; Slabas, A.R.
Inhibition and covalent modification of rape seed (Brassica napus) enoyl ACP reductase by phenylglyoxal
Biochim. Biophys. Acta
995
273-278
1989
Brassica napus
Cottingham, I.R.; Austin, A.; Sidebottom, C.; Slabas, A.R.
Purified enoyl-[acyl-carrier-protein] reductase frome rape seed (Brassica napus) contains two closely related polypeptides which differ by a six-amino-acid N-terminal extension
Biochim. Biophys. Acta
854
201-207
1988
Brassica napus
-
Slabas, A.R.; Sidebottom, C.M.; Hellyer, A.; Kessell, R.M.J.; Tombs, M.P.
Induction, purification and characterization of NADH-specific enoyl acyl carrier protein reductase from developing seeds of oil seed rape (Brassica napus)
Biochim. Biophys. Acta
877
271-280
1986
Brassica napus
-
Lessire, R.; Stumpf, P.K.
Nature of the fatty acid synthetase systems in parenchymal and epidermal cells of Allium porrum L. leaves
Plant Physiol.
73
614-618
1982
Allium ampeloprasum
Seyama, Y.; Kasama, T.; Yamakawa, T.; Kawaguchi, A.; Okuda, S.
Stereochemical studies of hydrogen incorporation from nucleotides with fatty acid synthetase from Brevibacterium ammoniagenes
J. Biochem.
81
1167-1173
1977
Corynebacterium ammoniagenes
Slabas, A.R.; Sidebottom, C.M.; Kessell, R.M.J; Hellyer, A.; Tombs, M.P.
Oilseed rape NADH enoyl acyl-carrier protein reductase
Biochem. Soc. Trans.
14
581-582
1986
Brassica napus
Baldock, C.; Rafferty, J.B.; Stuitje, A.R.; Slabas, A.R.; Rice, D.W.
The x-ray structure of Escherichia coli enoyl reductase with bound NAD+ at 2.1 ANG resolution
J. Mol. Biol.
284
1529-1546
1998
Escherichia coli
Rafferty, J.B.; Simon, J.W.; Stuitje, A.R.; Slabas, A.R.; Fawcett, T.; Rice, D.W.
Crystallization of the NADH-specific enoyl acyl carrier protein reductase from Brassica napus
J. Mol. Biol.
237
240-242
1994
Brassica napus
Basso, L.A.; Zheng, R.; Musser, J.M.; Jacobs, W.R., Jr.; Blanchard, J.S.
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates
J. Infect. Dis.
178
769-775
1998
Mycobacterium tuberculosis
Ward, W.H.J.; Holdgate, G.A.; Rowsell, S.; McLean, E.G.; Pauptit, R.A.; Clayton, E.; Nichols, W.W.; Colls, J.G.; Minshull, C.A.; Jude, D.A.; Mistry, A.; Timms, D.; Camble, R.; Hales, N.J.; Britton, C.J.; Taylor, I.W.F.
Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan
Biochemistry
38
12514-12525
1999
Escherichia coli (P0AEK4), Escherichia coli
Parikh, S.; Moynihan, D.P.; Xiao, G.; Tonge, P.J.
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis
Biochemistry
38
13623-13634
1999
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Roujeinikova, A.; Sedelnikova, S.; De Boer, G.J.; Stuitje, A.R.; Slabas, A.R.; Rafferty, J.B.; Rice, D.W.
Inhibitor binding studies on enoyl reductase reveal conformational changes related to substrate recognition
J. Biol. Chem.
274
30811-30817
1999
Brassica napus (P80030), Brassica napus
Suguna, K.; Surolia, A.; Surolia, N.
Structural basis for triclosan and NAD binding to enoyl-ACP reductase of Plasmodium falciparum
Biochem. Biophys. Res. Commun.
283
224-228
2001
Plasmodium falciparum
Marcinkeviciene, J.; Jiang, W.; Kopcho, L.M.; Locke, G.; Luo, Y.; Copeland, R.A.
Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene
Arch. Biochem. Biophys.
390
101-108
2001
Haemophilus influenzae
Kapoor, M.; Jamal Dar, M.; Surolia, A.; Surolia, N.
Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors
Biochem. Biophys. Res. Commun.
289
832-837
2001
Plasmodium falciparum
Lee, H.H.; Yun, J.; Moon, J.; Han, B.W.; Lee, B.I.; Lee, J.Y.; Suh, S.W.
Crystallization and preliminary x-ray crystallographic analysis of enoyl-acyl carrier protein reductase from Helicobacter pylori
Acta Crystallogr. Sect. D
58
1071-1073
2002
Helicobacter pylori
Muench, S.P.; Rafferty, J.B.; McLeod, R.; Rice, D.W.; Prigge, S.T.
Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase
Acta Crystallogr. Sect. D
59
1246-1248
2003
Plasmodium falciparum
Lee, I.H.; Kim, E.J.; Cho, Y.H.; Lee, J.K.
Characterization of a novel enoyl-acyl carrier protein reductase of diazaborine-resistant Rhodobacter sphaeroides mutant
Biochem. Biophys. Res. Commun.
299
621-627
2002
Cereibacter sphaeroides
Marrakchi, H.; Dewolf, W.E., Jr.; Quinn, C.; West, J.; Polizzi, B.J.; So, C.Y.; Holmes, D.J.; Reed, S.L.; Heath, R.J.; Payne, D.J.; Rock, C.O.; Wallis, N.G.
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK)
Biochem. J.
370
1055-1062
2003
Streptococcus pneumoniae
Kapoor, M.; Mukhi, P.L.; Surolia, N.; Suguna, K.; Surolia, A.
Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+
Biochem. J.
381
725-733
2004
Plasmodium falciparum
Kapoor, M.; Gopalakrishnapai, J.; Surolia, N.; Surolia, A.
Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum
Biochem. J.
381
735-741
2004
Plasmodium falciparum (Q9BH77), Plasmodium falciparum
Sivaraman, S.; Zwahlen, J.; Bell, A.F.; Hedstrom, L.; Tonge, P.J.
Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs
Biochemistry
42
4406-4413
2003
Escherichia coli (P0AEK4)
Protasevich, II; Brouillette, C.G.; Snow, M.E.; Dunham, S.; Rubin, J.R.; Gogliotti, R.; Siegel, K.
Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance
Biochemistry
43
13380-13389
2004
Escherichia coli (P0AEK4), Escherichia coli
Oliveira, J.S.; Sousa, E.H.; Basso, L.A.; Palaci, M.; Dietze, R.; Santos, D.S.; Moreira, I.S.
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis
Chem. Commun. (Camb.)
2004
312-313
2004
Mycobacterium tuberculosis
-
Seefeld, M.A.; Miller, W.H.; Newlander, K.A.; Burgess, W.J.; DeWolf, W.E., Jr.; Elkins, P.A.; Head, M.S.; Jakas, D.R.; Janson, C.A.; Keller, P.M.; Manley, P.J.; Moore, T.D.; Payne, D.J.; Pearson, S.; Polizzi, B.J.; Qiu, X.; Rittenhouse, S.F.; Uzinskas, I.N.; Wallis, N.G.; Huffman, W.F.
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK
J. Med. Chem.
46
1627-1635
2003
Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae
Sivaraman, S.; Sullivan, T.J.; Johnson, F.; Novichenok, P.; Cui, G.; Simmerling, C.; Tonge, P.J.
Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues
J. Med. Chem.
47
509-518
2004
Escherichia coli
Kirmizibekmez, H.; Calis, I.; Perozzo, R.; Brun, R.; Donmez, A.A.; Linden, A.; Ruedi, P.; Tasdemir, D.
Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP reductase, a crucial enzyme in fatty acid biosynthesis
Planta Med.
70
711-717
2004
Plasmodium falciparum
Hoang, T.T.; Schweizer, H.P.
Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis
J. Bacteriol.
181
5489-5497
1999
Pseudomonas aeruginosa
Muench, S.P.; Prigge, S.T.; Zhu, L.; Kirisits, M.J.; Roberts, C.W.; Wernimont, S.; McLeod, R.; Rice, D.W.
Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase
Acta Crystallogr. Sect. F
F62
604-606
2006
Toxoplasma gondii
Saito, J.; Yamada, M.; Watanabe, T.; Kitagawa, H.; Takeuchi, Y.
Crystallization and preliminary X-ray analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae
ACTA CRYSTALLOGR. SECT. F
62
576-578
2006
Streptococcus pneumoniae (Q8DR17), Streptococcus pneumoniae
Chhibber, M.; Kumar, G.; Parasuraman, P.; Ramya, T.N.; Surolia, N.; Surolia, A.
Novel diphenyl ethers: design, docking studies, synthesis and inhibition of enoyl ACP reductase of Escherichia coli and Escherichia coli
Bioorg. Med. Chem.
14
8086-8098
2006
Plasmodium falciparum, Escherichia coli (P0AEK4), Escherichia coli
Kitagawa, H.; Kumura, K.; Takahata, S.; Iida, M.; Atsumi, K.
4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI
Bioorg. Med. Chem.
15
1106-1116
2007
Escherichia coli, Staphylococcus aureus
Schroeder, E.K.; Basso, L.A.; Santos, D.S.; de Souza, O.N.
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities
Biophys. J.
89
876-884
2005
Mycobacterium tuberculosis
Moir, D.T.
Identification of inhibitors of bacterial enoyl-acyl carrier protein reductase
Curr. Drug Targets Infect. Disord.
5
297-305
2005
Staphylococcus aureus
Oliveira, J.S.; de Sousa, E.H.; de Souza, O.N.; Moreira, I.S.; Santos, D.S.; Basso, L.A.
Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex
Curr. Pharm. Des.
12
2409-2424
2006
Mycobacterium tuberculosis
Tasdemir, D.; Lack, G.; Brun, R.; Rueedi, P.; Scapozza, L.; Perozzo, R.
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids
J. Med. Chem.
49
3345-3353
2006
Plasmodium falciparum
Rafi, S.B.; Cui, G.; Song, K.; Cheng, X.; Tonge, P.J.; Simmerling, C.
Insight through molecular mechanics Poisson-Boltzmann surface area calculations into the binding affinity of triclosan and three analogues for FabI, the E. coli enoyl reductase
J. Med. Chem.
49
4574-4580
2006
Escherichia coli (P0AEK4)
He, X.; Alian, A.; Stroud, R.; Ortiz de Montellano, P.R.
Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Med. Chem.
49
6308-6323
2006
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Oliveira, J.S.; Pereira, J.H.; Canduri, F.; Rodrigues, N.C.; de Souza, O.N.; de Azevedo, W.F.; Basso, L.A.; Santos, D.S.
Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis
J. Mol. Biol.
359
646-666
2006
Mycobacterium tuberculosis
Tasdemir, D.; Guener, N.D.; Perozzo, R.; Brun, R.; Doenmez, A.A.; Calis, I.; Rueedi, P.
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots
Phytochemistry
66
355-362
2005
Plasmodium falciparum
Lu, H.; Tonge, P.J.
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway
Acc. Chem. Res.
41
11-20
2008
Mycobacterium tuberculosis
Kim, K.H.; Park, J.K.; Ha, B.H.; Moon, J.H.; Kim, E.E.
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis
Acta Crystallogr. Sect. F
63
246-248
2007
Bacillus subtilis, Bacillus subtilis 168
Nicola, G.; Smith, C.A.; Lucumi, E.; Kuo, M.R.; Karagyozov, L.; Fidock, D.A.; Sacchettini, J.C.; Abagyan, R.
Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening
Biochem. Biophys. Res. Commun.
358
686-691
2007
Plasmodium falciparum
Sharma, S.K.; Kumar, G.; Kapoor, M.; Surolia, A.
Combined effect of epigallocatechin gallate and triclosan on enoyl-ACP reductase of Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
368
12-17
2008
Mycobacterium tuberculosis
Bonnac, L.; Gao, G.Y.; Chen, L.; Felczak, K.; Bennett, E.M.; Xu, H.; Kim, T.; Liu, N.; Oh, H.; Tonge, P.J.; Pankiewicz, K.W.
Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis
Bioorg. Med. Chem. Lett.
17
4588-4591
2007
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Tipparaju, S.K.; Joyasawal, S.; Forrester, S.; Mulhearn, D.C.; Pegan, S.; Johnson, M.E.; Mesecar, A.D.; Kozikowski, A.P.
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
Bioorg. Med. Chem. Lett.
18
3565-3569
2008
Bacillus anthracis
Cai, X.; Lorraine Fuller, A.; McDougald, L.R.; Tan, X.; Cai, J.; Wang, F.; Sacchettini, J.C.; Zhu, G.
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa)
FEMS Microbiol. Lett.
272
238-244
2007
Eimeria tenella (A3R4P1)
Takahata, S.; Iida, M.; Yoshida, T.; Kumura, K.; Kitagawa, H.; Hoshiko, S.
Discovery of 4-pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus
J. Antibiot.
60
123-128
2007
Escherichia coli, Staphylococcus aureus
Park, H.S.; Yoon, Y.M.; Jung, S.J.; Kim, C.M.; Kim, J.M.; Kwak, J.H.
Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor
J. Antimicrob. Chemother.
60
568-574
2007
Staphylococcus aureus, Staphylococcus aureus RN4220
Freundlich, J.S.; Wang, F.; Tsai, H.C.; Kuo, M.; Shieh, H.M.; Anderson, J.W.; Nkrumah, L.J.; Valderramos, J.C.; Yu, M.; Kumar, T.R.; Valderramos, S.G.; Jacobs, W.R.; Schiehser, G.A.; Jacobus, D.P.; Fidock, D.A.; Sacchettini, J.C.
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy
J. Biol. Chem.
282
25436-25444
2007
Plasmodium falciparum
Massengo-Tiasse, R.P.; Cronan, J.E.
Vibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductase
J. Biol. Chem.
283
1308-1316
2008
Vibrio cholerae serotype O1
Kumar, G.; Parasuraman, P.; Sharma, S.K.; Banerjee, T.; Karmodiya, K.; Surolia, N.; Surolia, A.
Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase
J. Med. Chem.
50
2665-2675
2007
Plasmodium falciparum
Kumar, A.; Siddiqi, M.I.
CoMFA based de novo design of pyrrolidine carboxamides as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis
J. Mol. Model.
14
923-935
2008
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Dias, M.V.; Vasconcelos, I.B.; Prado, A.M.; Fadel, V.; Basso, L.A.; de Azevedo, W.F.; Santos, D.S.
Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis
J. Struct. Biol.
159
369-380
2007
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Lu, J.Z.; Muench, S.P.; Allary, M.; Campbell, S.; Roberts, C.W.; Mui, E.; McLeod, R.L.; Rice, D.W.; Prigge, S.T.
Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure
Parasitology
134
1949-1962
2007
Eimeria tenella
Karioti, A.; Skaltsa, H.; Zhang, X.; Tonge, P.J.; Perozzo, R.; Kaiser, M.; Franzblau, S.G.; Tasdemir, D.
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata
Phytomedicine
15
1125-1129
2008
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Plasmodium falciparum
Dayan, F.E.; Ferreira, D.; Wang, Y.H.; Khan, I.A.; McInroy, J.A.; Pan, Z.
A pathogenic fungi diphenyl ether phytotoxin targets plant enoyl (acyl carrier protein) reductase
Plant Physiol.
147
1062-1071
2008
Arabidopsis thaliana
Saito, J.; Yamada, M.; Watanabe, T.; Iida, M.; Kitagawa, H.; Takahata, S.; Ozawa, T.; Takeuchi, Y.; Ohsawa, F.
Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor
Protein Sci.
17
691-699
2008
Streptococcus pneumoniae, Streptococcus pneumoniae (Q8DR17)
Lee, H.H.; Moon, J.; Suh, S.W.
Crystal structure of the Helicobacter pylori enoyl-acyl carrier protein reductase in complex with hydroxydiphenyl ether compounds, triclosan and diclosan
Proteins Struct. Funct. Bioinform.
69
691-694
2007
Helicobacter pylori (O24990)
Banerjee, T.; Sharma, S.K.; Surolia, N.; Surolia, A.
Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum
Biochem. Biophys. Res. Commun.
377
1238-1242
2008
Plasmodium falciparum
Sampson, P.B.; Picard, C.; Handerson, S.; McGrath, T.E.; Domagala, M.; Leeson, A.; Romanov, V.; Awrey, D.E.; Thambipillai, D.; Bardouniotis, E.; Kaplan, N.; Berman, J.M.; Pauls, H.W.
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI)
Bioorg. Med. Chem. Lett.
19
5355-5358
2009
Escherichia coli, Staphylococcus aureus
Ramnauth, J.; Surman, M.D.; Sampson, P.B.; Forrest, B.; Wilson, J.; Freeman, E.; Manning, D.D.; Martin, F.; Toro, A.; Domagala, M.; Awrey, D.E.; Bardouniotis, E.; Kaplan, N.; Berman, J.; Pauls, H.W.
2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI
Bioorg. Med. Chem. Lett.
19
5359-5362
2009
Escherichia coli, Staphylococcus aureus
Massengo-Tiasse, R.P.; Cronan, J.E.
Diversity in enoyl-acyl carrier protein reductases
Cell. Mol. Life Sci.
66
1507-1517
2009
Escherichia coli, Mycobacterium tuberculosis
Subba Rao, G.; Vijayakrishnan, R.; Kumar, M.
Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis: a computer modelling approach
Chem. Biol. Drug Des.
72
444-449
2008
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Tipparaju, S.K.; Mulhearn, D.C.; Klein, G.M.; Chen, Y.; Tapadar, S.; Bishop, M.H.; Yang, S.; Chen, J.; Ghassemi, M.; Santarsiero, B.D.; Cook, J.L.; Johlfs, M.; Mesecar, A.D.; Johnson, M.E.; Kozikowski, A.P.
Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase
ChemMedChem
3
1250-1268
2008
Bacillus anthracis (A0A348A0U3), Bacillus anthracis
Frecer, V.; Megnassan, E.; Miertus, S.
Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase
Eur. J. Med. Chem.
44
3009-3019
2009
Plasmodium falciparum
Stigliani, J.L.; Arnaud, P.; Delaine, T.; Bernardes-Genisson, V.; Meunier, B.; Bernadou, J.
Binding of the tautomeric forms of isoniazid-NAD adducts to the active site of the Mycobacterium tuberculosis enoyl-ACP reductase (InhA): a theoretical approach
J. Mol. Graph. Model.
27
536-545
2008
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Kumar, A.; Siddiqi, M.I.
Receptor based 3D-QSAR to identify putative binders of Mycobacterium tuberculosis enoyl acyl carrier protein reductase
J. Mol. Model.
16
877-893
2010
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Morde, V.A.; Shaikh, M.S.; Pissurlenkar, R.R.; Coutinho, E.C.
Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors
Mol. Divers.
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2009
Plasmodium falciparum
Kim, S.J.; Ha, B.H.; Kim, K.H.; Hong, S.K.; Shin, K.J.; Suh, S.W.; Kim, E.E.
Dimeric and tetrameric forms of enoyl-acyl carrier protein reductase from Bacillus cereus
Biochem. Biophys. Res. Commun.
400
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2010
Bacillus cereus (Q81GI3), Bacillus cereus DSM 31 (Q81GI3)
Lu, H.; Tonge, P.J.
Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei
Biochemistry
49
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2010
Burkholderia mallei (Q62L02), Burkholderia mallei ATCC 23344 (Q62L02)
Kwon, Y.J.; Fang, Y.; Xu, G.H.; Kim, W.G.
Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611
Biol. Pharm. Bull.
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Streptococcus pneumoniae, Streptococcus pneumoniae KCTC 3932
Yao, J.; Zhang, Q.; Min, J.; He, J.; Yu, Z.
Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers
Bioorg. Med. Chem. Lett.
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2010
Escherichia coli (P0AEK4), Escherichia coli MG1655 (P0AEK4)
Kapoor, N.; Banerjee, T.; Babu, P.; Maity, K.; Surolia, N.; Surolia, A.
Design, development, synthesis, and docking analysis of 2-substituted triclosan analogs as inhibitors for Plasmodium falciparum enoyl-ACP reductase
IUBMB Life
61
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Plasmodium falciparum
Luckner, S.R.; Liu, N.; am Ende, C.W.; Tonge, P.J.; Kisker, C.
A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis
J. Biol. Chem.
285
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Tipparaju, S.K.; Muench, S.P.; Mui, E.J.; Ruzheinikov, S.N.; Lu, J.Z.; Hutson, S.L.; Kirisits, M.J.; Prigge, S.T.; Roberts, C.W.; Henriquez, F.L.; Kozikowski, A.P.; Rice, D.W.; McLeod, R.L.
Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase
J. Med. Chem.
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Toxoplasma gondii (Q6UCJ9)
Mehboob, S.; Truong, K.; Santarsiero, B.D.; Johnson, M.E.
Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD(+) and triclosan
Acta Crystallogr. Sect. F
66
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2010
Francisella tularensis (Q5NGQ3), Francisella tularensis SCHU S4 (Q5NGQ3)
Park, A.K.; Lee, J.H.; Chi, Y.M.; Moon, J.H.
Crystallization and preliminary X-ray crystallographic studies of a new class of enoyl-(acyl-carrier protein) reductase, FabV, from Vibrio fischeri
Acta Crystallogr. Sect. F
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2012
Aliivibrio fischeri (Q5E6G3)
Zhu, L.; Lin, J.; Ma, J.; Cronan, J.; Wang, H.
Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase
Antimicrob. Agents Chemother.
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Pseudomonas aeruginosa (Q9HZP8), Pseudomonas aeruginosa
Hu, K.; Zhao, M.; Zhang, T.; Zha, M.; Zhong, C.; Jiang, Y.; Ding, J.
Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism
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Yersinia pestis (Q8Z9U1)
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Detection of Escherichia coli enoyl-ACP reductase using biarsenical-tetracysteine motif
Bioconjug. Chem.
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Escherichia coli
Neves, B.J.; Bueno, R.V.; Braga, R.C.; Andrade, C.H.
Discovery of new potential hits of Plasmodium falciparum enoyl-ACP reductase through ligand- and structure-based drug design approaches
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Plasmodium falciparum
Deraeve, C.; Dorobantu, I.M.; Rebbah, F.; Le Quemener, F.; Constant, P.; Quemard, A.; Bernardes-Genisson, V.; Bernadou, J.; Pratviel, G.
Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as potential antimycobacterial agents
Bioorg. Med. Chem.
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Mycobacterium tuberculosis
de Medeiros, P.S.; Ducati, R.G.; Basso, L.A.; Santos, D.S.; da Silva, L.H.
Enzyme mechanism and slow-onset inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase by an inorganic complex
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Plasmodium falciparum
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X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition
IUBMB Life
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2010
Plasmodium falciparum (Q9BJJ9), Plasmodium falciparum
Banerjee, T.; Sharma, S.K.; Kapoor, N.; Dwivedi, V.; Surolia, N.; Surolia, A.
Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase
IUBMB Life
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Plasmodium falciparum
Maity, K.; Banerjee, T.; Prabakaran, N.; Surolia, N.; Surolia, A.; Suguna, K.
Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from Plasmodium falciparum
IUBMB Life
63
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2011
Plasmodium falciparum (Q9BJJ9), Plasmodium falciparum
Liu, N.; Cummings, J.E.; England, K.; Slayden, R.A.; Tonge, P.J.
Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei
J. Antimicrob. Chemother.
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Burkholderia pseudomallei (Q3JQY0), Burkholderia pseudomallei 1710b (Q3JQY0)
Kingry, L.C.; Cummings, J.E.; Brookman, K.W.; Bommineni, G.R.; Tonge, P.J.; Slayden, R.A.
The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection
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Francisella tularensis, Francisella tularensis SCHU S4
Hevener, K.E.; Mehboob, S.; Su, P.C.; Truong, K.; Boci, T.; Deng, J.; Ghassemi, M.; Cook, J.L.; Johnson, M.E.
Discovery of a novel and potent class of F. tularensis enoyl-reductase (FabI) inhibitors by molecular shape and electrostatic matching
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Francisella tularensis (Q5NGQ3), Francisella tularensis, Francisella tularensis SCHU S4 (Q5NGQ3)
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Panosialins, inhibitors of enoyl-ACP reductase from Streptomyces sp. AN1761
J. Microbiol. Biotechnol.
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Streptococcus pneumoniae, Mycobacterium tuberculosis
Kim, K.H.; Ha, B.H.; Kim, S.J.; Hong, S.K.; Hwang, K.Y.; Kim, E.E.
Crystal structures of enoyl-ACP reductases I (FabI) and III (FabL) from B. subtilis
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Bacillus subtilis (P54616), Bacillus subtilis, Bacillus subtilis 168 (P54616)
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Conformational changes in 2-trans-enoyl-ACP (CoA) reductase (InhA) from M. tuberculosis induced by an inorganic complex: a molecular dynamics simulation study
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Mycobacterium tuberculosis
Li, H.; Zhang, X.; Bi, L.; He, J.; Jiang, T.
Determination of the crystal structure and active residues of FabV, the enoyl-ACP reductase from Xanthomonas oryzae
PLoS ONE
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Xanthomonas oryzae (Q2P9J6)
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Identification of two enoyl-ACP reductase FabI1 and FabI2 in Brucella abortus
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Brucella abortus (Q57A95), Brucella abortus (Q57EU5)
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Dynamics of Plasmodium falciparum enoyl-ACP reductase and implications on drug discovery
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Plasmodium falciparum (Q9BJJ9), Plasmodium falciparum
Hirschbeck, M.W.; Kuper, J.; Lu, H.; Liu, N.; Neckles, C.; Shah, S.; Wagner, S.; Sotriffer, C.A.; Tonge, P.J.; Kisker, C.
Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors
Structure
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Yersinia pestis (Q8Z9U1)
Jordan, C.A.; Sandoval, B.A.; Serobyan, M.V.; Gilling, D.H.; Groziak, M.P.; Xu, H.H.; Vey, J.L.
Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors
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Escherichia coli (P0AEK4)
Vick, J.E.; Clomburg, J.M.; Blankschien, M.D.; Chou, A.; Kim, S.; Gonzalez, R.
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Escherichia coli
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Selectivity of pyridone- and diphenyl ether-based inhibitors for the Yersinia pestis FabV enoyl-ACP reductase
Biochemistry
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Yersinia pestis (Q8Z9U1), Yersinia pestis A1122 (Q8Z9U1)
Cheng, G.; Muench, S.P.; Zhou, Y.; Afanador, G.A.; Mui, E.J.; Fomovska, A.; Lai, B.S.; Prigge, S.T.; Woods, S.; Roberts, C.W.; Hickman, M.R.; Lee, P.J.; Leed, S.E.; Auschwitz, J.M.; Rice, D.W.; McLeod, R.
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase
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Toxoplasma gondii
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Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)
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Francisella tularensis subsp. tularensis (Q5NGQ3), Francisella tularensis subsp. tularensis Schu 4 (Q5NGQ3)
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Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent
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Staphylococcus aureus, Staphylococcus aureus MRSA
Lee, J.; Park, A.; Chi, Y.; Jeong, A.
Crystal structures of Pseudomonas aeruginosa enoyl-ACP reductase (FabI) in the presence and absence of NAD+ and triclosan
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Pseudomonas aeruginosa (Q9ZFE4)
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Ghattas, M.A.; Mansour, R.A.; Atatreh, N.; Bryce, R.A.
Analysis of enoyl-acyl carrier protein reductase structure and interactions yields an efficient virtual screening approach and suggests a potential allosteric site
Chem. Biol. Drug Des.
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Escherichia coli, Plasmodium falciparum, Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Liu, J.; Wu, J.; Li, Z.
Enoyl acyl carrier protein reductase (FabI) catalyzed asymmetric reduction of the C=C double bond of alpha,beta-unsaturated ketones: preparation of (R)-2-alkyl-cyclopentanones
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Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis
ChemMedChem
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2014
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Cheng, Y.R.; Sun, Z.J.; Cui, G.Z.; Song, X.; Cui, Q.
A new strategy for strain improvement of Aurantiochytrium sp. based on heavy-ions mutagenesis and synergistic effects of cold stress and inhibitors of enoyl-ACP reductase
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Functional characterization of triclosan-resistant enoyl-acyl-carrier protein reductase (FabV) in Pseudomonas aeruginosa
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Yao, J.; Ericson, M.E.; Frank, M.W.; Rock, C.O.
Enoyl-acyl carrier protein reductase I (FabI) is essential for the intracellular growth of Listeria monocytogenes
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Listeria monocytogenes
Belluti, F.; Perozzo, R.; Lauciello, L.; Colizzi, F.; Kostrewa, D.; Bisi, A.; Gobbi, S.; Rampa, A.; Bolognesi, M.L.; Recanatini, M.; Brun, R.; Scapozza, L.; Cavalli, A.
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Chollet, A.; Mourey, L.; Lherbet, C.; Delbot, A.; Julien, S.; Baltas, M.; Bernadou, J.; Pratviel, G.; Maveyraud, L.; Bernardes-Genisson, V.
Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Owono Owono, L.C.; Ntie-Kang, F.; Keita, M.; Megnassan, E.; Frecer, V.; Miertus, S.
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Mycobacterium tuberculosis, Plasmodium falciparum
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Sunflower (Helianthus annuus) fatty acid synthase complex enoyl-[acyl carrier protein]-reductase genes
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Parikh, S.; Xiao, G.; Tonge, P.
Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid
Biochemistry
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Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Schroeder, E.; Basso, L.; Santos, D.; De Souza, O.
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH Toward the understanding of NADH-InhA different affinities
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Subba Rao, G.; Vijayakrishnan, R.; Kumar, M.
Structure-based design of a novel class of potent inhibitors of InhA, the enoyl acyl carrier protein reductase from Mycobacterium tuberculosis A computer modelling approach
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Nguyen, M.; Quemard, A.; Marrakchi, H.; Bernadou, J.; Meunier, B.
The nonenzymatic activation of isoniazid by MnIII-pyrophosphate in the presence of NADH produces the inhibition of the enoyl-ACP reductase InhA from Mycobacterium tuberculosis
Chemistry
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Guardia, A.; Gulten, G.; Fernandez, R.; Gomez, J.; Wang, F.; Convery, M.; Blanco, D.; Martinez, M.; Perez-Herran, E.; Alonso, M.; Ortega, F.; Rullas, J.; Calvo, D.; Mata, L.; Young, R.; Sacchettini, J.; Mendoza-Losana, A.; Remuinan, M.
N-Benzyl-4-((heteroaryl)methyl)benzamides a new class of direct NADH-dependent 2-trans enoyl-acyl carrier protein reductase (InhA) inhibitors with antitubercular activity
ChemMedChem
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Pedgaonkar, G.; Sridevi, J.; Jeankumar, V.; Saxena, S.; Devi, P.; Renuka, J.; Yogeeswari, P.; Sriram, D.
Development of 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Rotta, M.; Pissinate, K.; Villela, A.; Back, D.; Timmers, L.; Bachega, J.; De Souza, O.; Santos, D.; Basso, L.; Machado, P.
Piperazine derivatives Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Luckner, S.; Liu, N.; Am Ende, C.; Tonge, P.; Kisker, C.
A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis
J. Biol. Chem.
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
Vasconcelos, I.; Basso, L.; Santos, D.
Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase Implications to function-based antitubercular agent design
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Mycobacterium tuberculosis
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Da Costa, A.; Pauli, I.; Dorn, M.; Schroeder, E.; Zhan, C.; De Souza, O.
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
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Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA
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Molle, V.; Gulten, G.; Vilcheze, C.; Veyron-Churlet, R.; Zanella-Cleon, I.; Sacchettini, J.; Jacobs Jr, W.; Kremer, L.
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
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Probing mechanisms of resistance to the tuberculosis drug isoniazid Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis
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A triclosan-resistance protein from the soil metagenome is a novel enoyl-acyl carrier protein reductase Structure-guided functional analysis
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
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Klebsiella pneumoniae (A0A0G3SXJ0), Klebsiella pneumoniae (W9BFS8), Klebsiella pneumoniae, Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WGR1)
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Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Joshi, S.D.; More, U.A.; Dixit, S.R.; Balmi, S.V.; Kulkarni, B.G.; Ullagaddi, G.; Lherbet, C.; Aminabhavi, T.M.
Chemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis
Bioorg. Chem.
75
181-200
2017
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1), Mycobacterium tuberculosis H37Rv
Rodriguez, F.; Saffon, N.; Sammartino, J.; Degiacomi, G.; Pasca, M.; Lherbet, C.
First triclosan-based macrocyclic inhibitors of InhA enzyme
Bioorg. Chem.
95
103498
2020
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
de Avila, M.B.; Bitencourt-Ferreira, G.; de Azevedo, W.F.
Structural basis for inhibition of enoyl-[acyl carrier protein] reductase (InhA) from Mycobacterium tuberculosis
Curr. Med. Chem.
27
745-759
2020
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis
Dogan, H.; Dogan, S.D.; Guenduez, M.G.; Krishna, V.S.; Lherbet, C.; Sriram, D.; Sahin, O.; Saripinar, E.
Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors
Eur. J. Med. Chem.
188
112035
2020
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Dogan, S.D.; Guenduez, M.G.; Dogan, H.; Krishna, V.S.; Lherbet, C.; Sriram, D.
Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors
Eur. J. Med. Chem.
199
112402
2020
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGR1)
Pflegr, V.; Horvath, L.; Stolariova, J.; Pal, A.; Kordulakova, J.; Bosze, S.; Vinsova, J.; Kratky, M.
Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity
Eur. J. Med. Chem.
223
113668
2021
Mycobacterium avium, Mycobacterium avium 330/88, Mycobacterium kansasii, Mycobacterium kansasii 235/80, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Yadav, S.; Mandal, H.; Saravanan, V.; Das, P.; Singh, S.
In vitro and in silico analysis of L. donovani enoyl acyl carrier protein reductase - A possible drug target
J. Biomol. Struct. Dyn.
39
6056-6069
2021
Leishmania donovani (E9BQL7), Leishmania donovani, Leishmania donovani AG83 (E9BQL7)
Jayaraman, M.; Ramadas, K.
An integrated computational investigation to unveil the structural impacts of mutation on the InhA structural gene of Mycobacterium tuberculosis
J. Mol. Graph. Model.
101
107768
2020
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Khan, A.M.; Shawon, J.; Halim, M.A.
Multiple receptor conformers based molecular docking study of fluorine enhanced ethionamide with Mycobacterium enoyl ACP reductase (InhA)
J. Mol. Graph. Model.
77
386-398
2017
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Joshi, S.; Kumar, S.; Patil, S.; Vijayakumar, M.; Kulkarni, V.; Nadagouda, M.; Badiger, A.; Lherbet, C.; Aminabhavi, T.
Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth
Med. Chem. Res.
28
1838-1863
2019
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
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Pinzi, L.; Lherbet, C.; Baltas, M.; Pellati, F.; Rastelli, G.
In silico repositioning of cannabigerol as a novel inhibitor of the enoyl acyl carrier protein (ACP) reductase (InhA)
Molecules
24
2567
2019
Mycobacterium tuberculosis (P9WGR1), Mycobacterium tuberculosis H37Rv (P9WGR1)
Unissa, A.; Dusthackeer, V.; Kumar, M.; Nagarajan, P.; Sukumar, S.; Kumari, V.; Lakshmi, A.; Hanna, L.
Variants of katG, inhA and nat genes are not associated with mutations in efflux pump genes (mmpL3 and mmpL7) in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from India
Tuberculosis
107
144-148
2017
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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