Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.3.1.83 - geranylgeranyl diphosphate reductase and Organism(s) Thermoplasma acidophilum and UniProt Accession Q9HKS9

for references in articles please use BRENDA:EC1.3.1.83
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This enzyme also acts on geranylgeranyl-chlorophyll a. The reaction occurs in three steps. Which order the three double bonds are reduced is not known.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Thermoplasma acidophilum
UNIPROT: Q9HKS9
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Thermoplasma acidophilum
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
geranylgeranyl reductase, chl p, ct2256, ppchl p, geranylgeranyl diphosphate reductase, nadph-dependent geranylgeranyl reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
geranylgeranyl reductase
SYSTEMATIC NAME
IUBMB Comments
geranylgeranyl-diphosphate:NADP+ oxidoreductase
This enzyme also acts on geranylgeranyl-chlorophyll a. The reaction occurs in three steps. Which order the three double bonds are reduced is not known.
CAS REGISTRY NUMBER
COMMENTARY hide
86922-67-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + 3 NADPH + 3 H+
phytyl diphosphate + 3 NADP+
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate + 3 NADPH + 3 H+
phytyl diphosphate + 3 NADP+
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
highly conserved regions of characterized geranylgeranyl reductases, GGRs, from archaea, plants, and bacteria, overview
physiological function
-
DGGR catalyzes a critical step in the biosynthesis of archaeal membrane lipids. The saturation of hydrocarbon chains confers the ability to resist hydrolysis and oxidation and helps archaea withstand extreme conditions
additional information
-
structural basis for recognition of a geranyl group by geranylgeranyl reductases, GGRs, overview
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 45000, calculated from amino acid sequence
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meadows, C.; Mingardon, F.; Garabedian, B.; Baidoo, E.; Benites, V.; Rodrigues, A.; Abourjeily, R.; Chanal, A.; Lee, T.
Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity
Biotechnol. Biofuels
11
340
2018
Archaeoglobus fulgidus (A0A075WDX8), Archaeoglobus fulgidus DSM 8774 (A0A075WDX8), Methanocaldococcus infernus, Methanosarcina acetivorans (Q8TSV3), Methanosarcina acetivorans DSM 2834 (Q8TSV3), Pyrolobus fumarii (G0EHJ8), Pyrolobus fumarii DSM 11204 (G0EHJ8), Streptomyces coelicolor, Sulfolobus acidocaldarius, Thermococcus nautili, Thermoplasma acidophilum
Manually annotated by BRENDA team