Information on EC 1.3.1.47 - alpha-santonin 1,2-reductase

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The expected taxonomic range for this enzyme is: Pseudomonas cichorii

EC NUMBER
COMMENTARY
1.3.1.47
-
RECOMMENDED NAME
GeneOntology No.
alpha-santonin 1,2-reductase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+
show the reaction diagram
proposed mechanism
-
1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+
show the reaction diagram
proposed mechanism
Pseudomonas cichorii S
-
-
1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
reductase,-alpha-santonin 1,2-
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
111070-23-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
capable of using santonin as sole source of carbon and energy
-
-
Manually annotated by BRENDA team
Pseudomonas cichorii S
capable of using santonin as sole source of carbon and energy
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
-
-
-
?
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
-
degradative pathway of alpha-santonin
-
-
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
Pseudomonas cichorii S
-
-
-
?
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
Pseudomonas cichorii S
-
degradative pathway of alpha-santonin
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
Pseudomonas cichorii, Pseudomonas cichorii S
-
degradative pathway of alpha-santonin
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NADPH
-
2fold higher reaction velocity as with NADH
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.067
-
alpha-santonin
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7
-
-
assay at
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6
8
-
no change in activity
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
8-10°C, activity reduced
-
below 0°C, 50% loss of activity after 48 h
-