Information on EC 1.3.1.47 - alpha-santonin 1,2-reductase

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The expected taxonomic range for this enzyme is: Pseudomonas cichorii

EC NUMBER
COMMENTARY hide
1.3.1.47
-
RECOMMENDED NAME
GeneOntology No.
alpha-santonin 1,2-reductase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
111070-23-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
capable of using santonin as sole source of carbon and energy
-
-
Manually annotated by BRENDA team
capable of using santonin as sole source of carbon and energy
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-santonin + NAD(P)H
1,2-dihydrosantonin + NAD(P)+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
-
2fold higher reaction velocity as with NADH
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.067
alpha-santonin
-
-
0.044
NADH
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 8
-
no change in activity
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
8-10°C, activity reduced
-
below 0°C, 50% loss of activity after 48 h
-