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Information on EC 1.3.1.38 - trans-2-enoyl-CoA reductase (NADPH) and Organism(s) Caenorhabditis elegans and UniProt Accession Q9XXC8

for references in articles please use BRENDA:EC1.3.1.38
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EC Tree
IUBMB Comments
Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: Q9XXC8
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The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
trans-2-enoyl-coa reductase, mecr-1, nadph-dependent trans-2-enoyl-coa reductase, mitochondrial 2-trans-enoyl-thioester reductase, egter1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mitochondrial 2-trans-enoyl-CoA/ACP reductase
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mitochondrial 2-trans-enoyl-thioester reductase
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mitochondrial 2-trans-enoyl-CoA/ACP reductase
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mitochondrial 2-trans-enoyl-thioester reductase
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NADPH-dependent trans-2-enoyl-CoA reductase
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-
-
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reductase, trans-enoyl coenzyme A
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
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oxidation
-
-
-
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reduction
-
-
-
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dehydrogenation
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:NADP+ trans-2-oxidoreductase
Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
CAS REGISTRY NUMBER
COMMENTARY hide
77649-64-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-trans-hexenoyl-CoA + NADPH
?
show the reaction diagram
-
-
-
?
2-trans-hexenoyl-CoA + NADPH
?
show the reaction diagram
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-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.2
mutant cells over-expressiong MECR-1
3.21
cells overexpressing native Etr1p
0.2
mutant cells over-expressiong MECR-1
3.21
cells overexpressing native Etr1p
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
knockdown of MECR-1 resulted in life span extension
malfunction
knockdown of MECR-1 resulted in life span extension
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MECR2_CAEEL
346
0
37944
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae DELTA etr1 cells
expression in Saccharomyces cerevisiae DELTA etr1 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gurvitz, A.
A C. elegans model for mitochondrial fatty acid synthase II: the longevity-associated gene W09H1.5/mecr-1 encodes a 2-trans-enoyl-thioester reductase
PLoS ONE
4
e7791
2009
Caenorhabditis elegans (O45903), Caenorhabditis elegans (Q9XXC8), Caenorhabditis elegans
Manually annotated by BRENDA team