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Information on EC 1.3.1.38 - trans-2-enoyl-CoA reductase (NADPH) and Organism(s) Cavia porcellus and UniProt Accession Q9JIF5

for references in articles please use BRENDA:EC1.3.1.38
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EC Tree
IUBMB Comments
Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
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This record set is specific for:
Cavia porcellus
UNIPROT: Q9JIF5
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The taxonomic range for the selected organisms is: Cavia porcellus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
trans-2-enoyl-coa reductase, nadph-dependent trans-2-enoyl-coa reductase, mecr-1, mitochondrial 2-trans-enoyl-thioester reductase, egter1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NADPH-dependent trans-2-enoyl-CoA reductase
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-
-
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reductase, trans-enoyl coenzyme A
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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-
-
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oxidation
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-
-
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reduction
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-
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dehydrogenation
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-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:NADP+ trans-2-oxidoreductase
Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
CAS REGISTRY NUMBER
COMMENTARY hide
77649-64-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
trans-2-decenoyl-CoA + NADPH
decanoyl-CoA + NADP+
show the reaction diagram
highest activity with, native and recombinant enzyme
-
?
trans-2-hexenoyl-CoA + NADPH
hexanoyl-CoA + NADP+
show the reaction diagram
50% activity compared to that with trans-2-decenoyl-CoA, native and recombinant enzyme
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?
trans-2-octenoyl-CoA + NADPH
octanoyl-CoA + NADP+
show the reaction diagram
50% activity compared to that with trans-2-decenoyl-CoA, native and recombinant enzyme
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
specific for
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
N-ethylmaleimide
native and recombinant enzyme
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.038 - 0.053
NADPH
0.011 - 0.018
trans-2-decenoyl-CoA
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0752
partially purified
0.346
purified recombinant enzyme
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
guinea pig
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PECR_CAVPO
302
0
32529
Swiss-Prot
other Location (Reliability: 5)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
? * 32500-40000, sequence determination and SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
associated with peroxisomal acyldihydroxyacetone phosphate reductase
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression as His-tagged protein in Escherichia coli, sequence analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Das, A.K.; Uhler, M.D.; Hajra, A.K.
Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs
J. Biol. Chem.
275
24333-24340
2000
Cavia porcellus (Q9JIF5), Cavia porcellus, Homo sapiens (Q9BY49), Homo sapiens, Mus musculus (Q99MZ7), Mus musculus
Manually annotated by BRENDA team