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IUBMB CommentsNot identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
trans-2-enoyl-coa reductase, mecr-1, nadph-dependent trans-2-enoyl-coa reductase, mitochondrial 2-trans-enoyl-thioester reductase, egter1,
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mitochondrial 2-trans-enoyl-CoA/ACP reductase
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mitochondrial 2-trans-enoyl-thioester reductase
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mitochondrial 2-trans-enoyl-CoA/ACP reductase
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mitochondrial 2-trans-enoyl-thioester reductase
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NADPH-dependent trans-2-enoyl-CoA reductase
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reductase, trans-enoyl coenzyme A
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acyl-CoA:NADP+ trans-2-oxidoreductase
Not identical with EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
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2-trans-hexenoyl-CoA + NADPH
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2-trans-hexenoyl-CoA + NADPH
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0.2
mutant cells over-expressiong MECR-1
3.21
cells overexpressing native Etr1p
0.2
mutant cells over-expressiong MECR-1
3.21
cells overexpressing native Etr1p
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UniProt
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malfunction
knockdown of MECR-1 resulted in life span extension
malfunction
knockdown of MECR-1 resulted in life span extension
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MECR1_CAEEL
344
0
38195
Swiss-Prot
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additional information
knockdown of MECR-1 resulted in life span extension
additional information
knockdown of MECR-1 resulted in life span extension
additional information
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knockdown of MECR-1 resulted in life span extension
additional information
knockdown of MECR-1 resulted in life span extension
additional information
knockdown of MECR-1 resulted in life span extension
additional information
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knockdown of MECR-1 resulted in life span extension
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expression in Saccharomyces cerevisiae DELTA etr1 cells
expression in Saccharomyces cerevisiae DELTA etr1 cells
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Gurvitz, A.
A C. elegans model for mitochondrial fatty acid synthase II: the longevity-associated gene W09H1.5/mecr-1 encodes a 2-trans-enoyl-thioester reductase
PLoS ONE
4
e7791
2009
Caenorhabditis elegans (O45903), Caenorhabditis elegans (Q9XXC8), Caenorhabditis elegans
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