Information on EC 1.3.1.37 - cis-2-enoyl-CoA reductase (NADPH)

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY
1.3.1.37
-
RECOMMENDED NAME
GeneOntology No.
cis-2-enoyl-CoA reductase (NADPH)
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH + H+
show the reaction diagram
mechanism: anti addition via 2Si, 2Re attack on cis double bond
-
acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH + H+
show the reaction diagram
mechanism: anti addition via 2Si, 2Re attack on cis double bond
Escherichia coli K12
-
-
acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH + H+
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:NADP+ cis-2-oxidoreductase
Not identical with EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH) [cf. EC 1.3.1.8 acyl-CoA dehydrogenase (NADP+)].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
cis-2-enoyl-coenzyme A reductase
-
-
-
-
NADPH-dependent cis-enoyl-CoA reductase
-
-
-
-
reductase, cis-2-enoyl coenzyme A
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
72841-00-0
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Escherichia coli K12
strain K12
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cis-2-decenoyl-CoA + NADPH + H+
decanoyl-CoA + NADP+
show the reaction diagram
Escherichia coli, Escherichia coli K12
-
no reduction of cis-3-enoyl substrates
-
?
cis-2-dodecenoyl-CoA + NADPH + H+
dodecanoyl-CoA + NADP+
show the reaction diagram
Escherichia coli, Escherichia coli K12
-
-
-
?
cis-2-octenoyl-CoA + NADPH + H+
octanoyl-CoA + NADP+
show the reaction diagram
-
-
-
-
cis-2-octenoyl-CoA + NADPH + H+
octanoyl-CoA + NADP+
show the reaction diagram
-
-
-
-
cis-2-octenoyl-CoA + NADPH + H+
octanoyl-CoA + NADP+
show the reaction diagram
Escherichia coli, Escherichia coli K12
-
stereochemistry
-
?
cis-2-octenoyl-CoA + NADPH + H+
octanoyl-CoA + NADP+
show the reaction diagram
Escherichia coli K12
-
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
iodoacetic acid
-
1 mM, 34% inhibition
p-hydroxymercuribenzoate
-
1 mM, 77% inhibition
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.02
-
cis-2-Octenoyl-CoA
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.0005
-
-
-
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
45
-
-
no loss of activity after 30 min
55
-
-
10 min, inactivation
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, ammonium sulfate precipitate
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE