Reference on EC 1.3.1.22 - 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Li, X.; Bertics, P.J.; Karavolas, H.J.
Regional distribution of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductases in female rat brain
J. Steroid Biochem. Mol. Biol.
60
311-318
1997
Rattus norvegicus
Krause, J.E.; Karavolas, H.J.
Subcellular location of hypothalamic progesterone metabolizing enzymes and evidence for distinct NADH- and NADPH-linked 3alpha-hydroxysteroid oxidoreductase activities
J. Steroid Biochem.
13
271-280
1980
Rattus norvegicus
Karavolas, H.J.; Hodges, D.R.
Changes in pituitary, hypothalamic and brain progestin-metabolizing enzyme activities during lactation
J. Steroid Biochem. Mol. Biol.
44
299-303
1993
Rattus norvegicus
Seitz, H.U.; Gaertner, D.E.
Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea
Plant Cell Tissue Organ Cult.
38
337-344
1994
Digitalis purpurea
-
Bertics, P.J.; Edman, C.F.; Karavolas, H.J.
Potent inhibition of the hypothalamic progesterone 5alpha-reductase by a 5alpha-dihydroprogesterone analog
J. Biol. Chem.
259
107-111
1984
Rattus norvegicus
Stuhlemmer, U.; Kreis, W.
Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata
Plant Physiol. Biochem.
34
85-91
1996
Digitalis lanata
-
Lindemann, P.; Luckner, M.
Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata
Phytochemistry
46
507-513
1997
Digitalis lanata
-
Wilton, D.C.
Is a Schiff base involved in the mechanism of the DELTA4-3-oxo steroid 5alpha- or 5beta-reductases from mammalian liver?
Biochem. J.
155
487-491
1976
Rattus norvegicus
Wendroth, S.; Seitz, H.U.
Characterization and localization of progesterone 5alpha-reductase from cell cultures of foxglove (Digitalis lanata EHRH)
Biochem. J.
266
41-46
1990
Digitalis lanata
Bertics, P.J.; Karavolas, H.J.
Pituitary progesterone 5alpha-reductase: solubilization and partial characterization
J. Steroid Biochem.
22
795-802
1985
Rattus norvegicus
Bertics, P.J.; Karavolas, H.J.
Partial characterization of the microsomal and solubilized hypothalamic progesterone 5alpha-reductase
J. Steroid Biochem.
21
305-314
1984
Rattus norvegicus
Roselli.C.E.; Snipes, C.A.
Progesterone 5alpha-reductase in mouse brain
Brain Res.
305
197-202
1984
Mus musculus
Holt, D.A.; Levy, M.A.; Oh, H.J.; Erb, J.M.; Heaslip, J.I.; Brandt, M.; Lan-Hargest, H.Y.; Metcalf, B.W.
Inhibition of steroid 5alpha-reductase by unsaturated 3-carboxysteroids
J. Med. Chem.
33
943-950
1990
Homo sapiens, Rattus norvegicus
Holt, D.A.; Levy, M.A.; Ladd, D.L.; Oh, H.J.; Erb, J.M.; Heaslip, J.I.; Brandt, M.; Metcalf, B.M.
Steroidal A ring aryl carboxylic acids: a new class of steroid 5alpha-reductase inhibitors
J. Med. Chem.
33
937-942
1990
Homo sapiens, Rattus norvegicus
Metcalf, B.W.; Holt, D.A.; Levy, M.A.; Erb, J.M.; Heaslip, J.I.; Brandt, M.; Oh, H.J.
Potent inhibition of human steroid 5alpha-reductase (EC 1.3.1.30) by 3-androstene-3-carboxylic acids
Bioorg. Chem.
17
372-376
1989
Homo sapiens
-
Campbell, J.S.; Karavolas, H.J.
The kinetic mechanism of the hypothalamic progesterone 5alpha-reductase
J. Steroid Biochem.
32
283-289
1989
Rattus norvegicus
Cheng, Y.J.; Karavolas, H.J.
Properties and subcellular distribution of DELTA4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary
Steroids
26
57-71
1975
Rattus norvegicus
Ichihara, K.; Tanaka, C.
Specific stimulation of steroid 5alpha-reductase solubilized from rat liver microsomes by endogenous phosphatidylserine
Biochem. Biophys. Res. Commun.
149
482-487
1987
Rattus norvegicus
Cheng, Y.J.; Karavolas, H.J.
Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus
J. Biol. Chem.
250
7997-8003
1975
Rattus norvegicus
McGuire, J.S.; Hollis, V.W.; Tomkins, G.M.
Some characteristics of the microsomal steroid reductase (5alpha) of rat liver
J. Biol. Chem.
235
3112-3117
1960
Rattus norvegicus
-
Golf, S.W.; Graef, V.; Staudinger, H.
Studies on the mechanism of the DELTA-4-3-oxosteroid-5alpha-reduction in rat liver microsomes
Hoppe-Seyler's Z. Physiol. Chem.
355
1499-1507
1974
Rattus norvegicus
Robaire, B.; Ewing, L.L.; Zirkin, B.R.; Irby, D.C.
Steroid DELTA4-5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase in the rat epididymis
Endocrinology
101
1379-1390
1977
Rattus norvegicus
Enderle-Schmitt, U.; Neuhaus, C.; Aumuller, G.
Solubilization of nuclear steroid 5alpha-reductase from rat ventral prostate
Biochim. Biophys. Acta
987
21-28
1989
Rattus norvegicus
Moore, R.J.; Wilson, J.D.
Reduced nicotinamide adenine dinucleotide phosphate delta4-3-ketosteroid 5alpha-oxidoreductase (rat ventral prostate)
Methods Enzymol.
36A
466-474
1975
Rattus norvegicus
Watkins, W.J.; Goldring, C.E.P.; Gower, D.B.
Properties of 4-ene-5alpha-reductase in porcine testicular microsomes
Biochem. Soc. Trans.
14
339-340
1986
Sus scrofa
-
Watkins, W.J.; Gower, D.B.
DELTA4-Steroid 5alpha-reductase activity in porcine testicular microsomes
Biochem. Soc. Trans.
13
187-188
1985
Sus scrofa
-
Frederiksen, D.W.; Wilson, J.D.
Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: DELTA 4-3-ketosteroid 5alpha-oxidoreductase of rat prostate
J. Biol. Chem.
246
2584-2593
1971
Rattus norvegicus
Watkins, W.J.; Wilson, L.; Gower, D.B.
Solubilization of 4-ene-5alpha-reductase from porcine testicular microsomes
Biochem. Soc. Trans.
14
979
1986
Sus scrofa
-
Graef, V.; Golf, S.W.; Tuschen, M.
NADPH: 4-ene-3-oxosteroid-5alpha-reductase and NADH: 4-ene-3-oxosteroid-5alpha-reductase in liver microsomes of different species of animals
J. Steroid Biochem.
14
883-887
1981
Gallus gallus, Chinchilla chinchilla, Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Sus scrofa
Lotz, W.
Importance of 5alpha-reduction for the trophic effects of androgens on rat accessory sex organs and LH control
J. Steroid Biochem.
13
1261-1264
1980
Rattus norvegicus
Sholiton, L.J.; Grossman, C.J.; Taylor, B.B.
Rat thymic homogenates convert testosterone to androgenic metabolites
J. Steroid Biochem.
13
1365-1367
1980
Rattus norvegicus
Thouvenot, D.; Morfin, R.F.
Interferences of zearalenone, zearalanol or estradiol-17beta with the steroid-metabolizing enzymes of the human prostate gland
J. Steroid Biochem.
13
1337-1345
1980
Homo sapiens
Kondo, K.; Aono, T.; Furubayashi, Y.; Terada, N.; Matsumoto, K.
Hormonal regulation of activities of 4-ene-5alpha-reductase and 17beta-ol-dehydrogenase in adult androgene-sterilized rat ovaries
J. Steroid Biochem.
13
703-705
1986
Rattus norvegicus
Blohm, T.R.; Metcalf, B.W.; Laughlin, M.E.; Sjoerdsma, A.; Schatzman, G.L.
Inhibition of testosterone 5alpha-reductase by a proposed enzyme-activated, active site-directed inhibitor
Biochem. Biophys. Res. Commun.
95
273-280
1980
Rattus norvegicus
Koninckx, P.; Verhoeven, G.; Heyns, W.; De Moore, P.
Biochemical characterization of the NADPH: 4-ene-3-ketosteroid 5alpha-oxidoreductase in rat ovarian suspension cultures
J. Steroid Biochem.
10
325-333
1979
Rattus norvegicus
Voigt, W.; Hsia, S.I.
Further studies on testosterone 5 -reductase of human skin. Structural features of steroid inhibitors
J. Biol. Chem.
248
4280-4285
1973
Homo sapiens
Moore, R.J.; Wilson, J.D.
Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities
J. Biol. Chem.
251
5895-5900
1976
Homo sapiens
Wallace, A.M.; Grant, J.K.
Effect of zinc on androgen metabolism in the human hyperplastic prostate
Biochem. Soc. Trans.
3
540-542
1975
Homo sapiens
Moore, R.J.; Wilson, J.D.
Extraction of the reduced nicotinamide adenine dinucleotide phosphate:delta 4-3-ketosteroid-5-alpha oxidoreductase of rat prostate with digitonin and potassium chloride
Biochemistry
13
450-456
1974
Rattus norvegicus
Scheer, H.; Robaire, B.
Solubilization and partial characterization of rat epididymal delta 4-steroid 5alpha-reductase (cholestenone 5alpha-reductase)
Biochem. J.
211
65-74
1983
Rattus norvegicus
Cowan, R.A.; Cook, B.; Cowan, S.K.; Grant, J.K.; Sirett, D.A.N.; Wallace, A.M.
Testosterone 5alpha-reductase and the accumulation of dihydrotestosterone in benign prostatic hyperplasia
J. Steroid Biochem.
11
609-613
1979
Homo sapiens
Shefer, S.; Hauser, S.; Mosbach, E.H.
Studies on the biosynthesis of 5alpha-cholestan-3beta-ol 1.Cholestenone of rat liver
J. Biol. Chem.
241
946-952
1965
Rattus norvegicus
Jurman, M.E.; Erulkar, S.D.; Krieger, N.R.
Testosterone 5alpha-reductase in spinal cord of Xenopus laevis
J. Neurochem.
38
657-661
1982
Xenopus laevis
Bhattacharyya, A.K.; Chavan, A.J.; Haley, B.E.; Taylor, M.F.; Collins, D.C.
Identification of the NADP(H) binding site of rat liver microsomal 5alpha-reductase (isoenzyme-1): purification of a photolabeled peptide corresponding to the adenine binding domain
Biochemistry
34
3663-3669
1995
Rattus norvegicus
Tian, G.; Mook, R.; Moss, M.L.; Frye, S.V.
Mechanism of time-dependent inhibition of 5alpha-reductases by delta 1-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies
Biochemistry
34
13453-13459
1995
Homo sapiens
Wigley, W.C.; Prihoda, J.S.; Mowszowicz, I.; Mendonca, B.B.; New, M.I.; Wilson, J.D.; Russel, D.W.
Natural mutagenesis study of the human steroid 5alpha-reductase 2 isozyme
Biochemistry
33
1265-1270
1994
Homo sapiens
Quemener, E.; Amet, Y.; Fournier, G.; Di Stefano, S.; Abalain, J.H.; Floch, H.H.
Glyosylated nature of testosterone 5alpha-reductase 2 purified from human prostate
Biochem. Biophys. Res. Commun.
205
296-274
1994
Homo sapiens
-
Delos, S.; Iehle, C.; Martin, M.; Raynaud, J.P.
Inhibition of the activity of basic 5alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cells
J. Steroid Biochem. Mol. Biol.
48
347-352
1994
Homo sapiens, Spodoptera frugiperda
Levy, M.A.; Brandt, M.; Sheedy, K.M.; Holt, D.A.; Heaslip, J.I.; Trill, J.J.; Ryan, P.J.; Morris, R.A.; Garrison, L.M.; Bergsma, D.J.
Cloning, expression and functional characterization of type 1 and type 2 steroid 5alpha-reductase from cynomolgus monkey: comparison with human and rat isoenzymes
J. Steroid Biochem. Mol. Biol.
52
307-319
1995
Macaca fascicularis, Homo sapiens, Rattus norvegicus
Span, P.N.; Smals, A.G.; Sweep, C.G.; Benraad, T.J.
Rat steroid 5alpha-reductase kinetic characteristics: extreme pH-dependancy of the type II isozyme in prostate and epididymis homogenates
J. Steroid Biochem. Mol. Biol.
54
185-192
1995
Rattus norvegicus
Beckmann, M.W.; Wieacker, P.; Dereser, M.M.; Flecken, U.; Breckwoldt, M.
Influence of steroid hormones on 5alpha-reductase activity in female and male genital skin fibroblats in culture
Acta Endocrinol.
128
161-167
1993
Homo sapiens
Cooke, G.M.; Pothier, F.; Murphy, B.D.
The effects of progesterone, 4,16-androstadien-3-one and MK-434 on the kinetics of pig testis microsomal testosterone-4-ene 5alpha-reductase activity
J. Steroid Biochem. Mol. Biol.
60
353-359
1997
Homo sapiens, Sus scrofa
Kaefer, M.; Audia, J.E.; Bruchovsky, N.; Goode, R.L.; Hsiao, K.C.; Leibovitch, I.Y.; Krushinski, J.H.; Lee, C; Steidle, C.P.; et al.
Charaterization of type I 5alpha-reductase activity in DU145 human prostatic adenocarcinoma cells
J. Steroid Biochem. Mol. Biol.
58
195-205
1996
Homo sapiens
Baxter, F.O.; Trivic, S.; Lee, I.R.
Structure-function studies of human 5alpha-reductase type 2 using site directed mutagenesis
J. Steroid Biochem. Mol. Biol.
77
167-175
2001
Homo sapiens
Matsuda, H.; Yamazaki, M.; Naruo, S.; Asanuma, Y.; Kubo, M.
Anti-androgenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5alpha-reductase
Biol. Pharm. Bull.
25
622-626
2002
Rattus norvegicus
Killian, J.; Pratis, K.; Clifton, R.J.; Stanton, P.G.; Robertson, D.M.; O'Donnell, L.
5alpha-reductase isoenzymes 1 and 2 in the rat testis during postnatal development
Biol. Reprod.
68
1711-1718
2003
Rattus norvegicus
Lee, H.H.; Ho, C.T.; Lin, J.K.
Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells
Carcinogenesis
25
1109-1118
2004
Homo sapiens, Rattus norvegicus
Cabeza, M.; Flores, E.; Heuze, I.; Sanchez, M.; Bratoeff, E.; Ramirez, E.; Francolugo, V.A.
Novel 17 substituted pregnadiene derivatives as 5alpha-reductase inhibitors and their binding affinity for the androgen receptor
Chem. Pharm. Bull.
52
535-539
2004
Mesocricetus auratus
Assinder, S.J.; Johnson, C.; King, K.; Nicholson, H.D.
Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate
Endocrinology
145
5767-5773
2004
Rattus norvegicus
Pratis, K.; O'Donnell, L.; Ooi, G.T.; Stanton, P.G.; McLachlan, R.I.; Robertson, D.M.
Differential regulation of rat testicular 5alpha-reductase type 1 and 2 isoforms by testosterone and FSH
J. Endocrinol.
176
393-403
2003
Rattus norvegicus
Picard, F.; Hartmann, R.W.
N-Substituted 4-(4-carboxyphenoxy)benzamides.: Synthesis and evaluation as inhibitors of steroid 5alpha-reductase type 1 and 2
J. Enzyme Inhib. Med. Chem.
17
187-196
2002
Homo sapiens, Rattus norvegicus
Picard, F.; Barassin, S.; Mokhtarian, A.; Hartmann, R.W.
Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors
J. Med. Chem.
45
3406-3417
2002
Homo sapiens, Rattus norvegicus
Raynaud, J.P.; Cousse, H.; Martin, P.M.
Inhibition of type 1 and type 2 5alpha-reductase activity by free fatty acids, active ingredients of Permixon
J. Steroid Biochem. Mol. Biol.
82
233-239
2002
Homo sapiens
Occhiato, E.G.; Guarna, A.; Danza, G.; Serio, M.
Selective non-steroidal inhibitors of 5alpha-reductase type 1
J. Steroid Biochem. Mol. Biol.
88
1-16
2004
Homo sapiens
Ranjan, M.; Diffley, P.; Stephen, G.; Price, D.; Walton, T.J.; Newton, R.P.
Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues: sensitivity to inhibition by finasteride and epristeride
Life Sci.
71
115-126
2002
Homo sapiens
Mahendroo, M.; Wilson, J.D.; Richardson, J.A.; Auchus, R.J.
Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse testes by two pathways
Mol. Cell. Endocrinol.
222
113-120
2004
Mus musculus
Basse, C.W.; Kerschbamer, C.; Brustmann, M.; Altmann, T.; Kahmann, R.
Evidence for a Ustilago maydis steroid 5alpha-reductase by functional expression in Arabidopsis det2-1 mutants
Plant Physiol.
129
717-732
2002
Ustilago maydis (Q8NJV1)
Shirakawa, T.; Okada, H.; Acharya, B.; Zhang, Z.; Hinata, N.; Wada, Y.; Uji, T.; Kamidono, S.; Gotoh, A.
Messenger RNA levels and enzyme activities of 5alpha-reductase types 1 and 2 in human benign prostatic hyperplasia (BPH) tissue
Prostate
58
33-40
2004
Homo sapiens
Flores, E.; Cabeza, M.; Quiroz, A.; Bratoeff, E.; Garcia, G.; Ramirez, E.
Effect of a novel steroid (PM-9) on the inhibition of 5alpha-reductase present in Penicillium crustosum broths
Steroids
68
271-275
2003
Penicillium crustosum
Woelfling, J.; Hackler, L.; Mernyak, E.; Schneider, G.; Toth, I.; Szecsi, M.; Julesz, J.; Sohar, P.; Csampai, A.
Neighboring group participation. Part 15. Stereoselective synthesis of some steroidal tetrahydrooxazin-2-ones, as novel presumed inhibitors of human 5alpha-reductase
Steroids
69
451-460
2004
Homo sapiens
Goodarzi, M.O.; Shah, N.A.; Antoine, H.J.; Pall, M.; Guo, X.; Azziz, R.
Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women
J. Clin. Endocrinol. Metab.
91
4085-4091
2006
Homo sapiens
Makridakis, N.; Reichardt, J.K.
Pharmacogenetic analysis of human steroid 5alpha reductase type II: Comparison of finasteride and dutasteride
J. Mol. Endocrinol.
34
617-623
2005
Homo sapiens
Guzman, D.C.; Mejia, G.B.; Vazquez, I.E.; Garcia, E.H.; del Angel, D.S.; Olguin, H.J.
Effect of testosterone and steroids homologues on indolamines and lipid peroxidation in rat brain
J. Steroid Biochem. Mol. Biol.
94
369-373
2005
Rattus norvegicus
Rosati, F.; Bardazzi, I.; De Blasi, P.; Simi, L.; Scarpi, D.; Guarna, A.; Serio, M.; Racchi, M.L.; Danza, G.
5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes
J. Steroid Biochem. Mol. Biol.
96
287-299
2005
Arabidopsis thaliana, Solanum lycopersicum (Q5K2N1), Solanum lycopersicum
Sanchez, P.; Torres, J.M.; Ortega, E.
Effects of dihydrotestosterone on brain mRNA levels of steroid 5alpha-reductase isozymes in early postnatal life of rat
Neurochem. Res.
30
577-581
2005
Rattus norvegicus
Thomas, L.N.; Lazier, C.B.; Gupta, R.; Norman, R.W.; Troyer, D.A.; OBrien, S.P.; Rittmaster, R.S.
Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer
Prostate
63
231-239
2005
Homo sapiens
Borst, S.E.; Conover, C.F.; Carter, C.S.; Gregory, C.M.; Marzetti, E.; Leeuwenburgh, C.; Vandenborne, K.; Wronski, T.J.
Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase
Am. J. Physiol. Endocrinol. Metab.
293
E507-E514
2007
Rattus norvegicus
Rittmaster, R.S.
5alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction
Best Pract. Res. Clin. Endocrinol. Metab.
22
389-402
2008
Homo sapiens
Liu, S.; Yamauchi, H.
Different patterns of 5alpha-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells
Biochem. Biophys. Res. Commun.
368
858-864
2008
Homo sapiens
Hirata, N.; Tokunaga, M.; Naruto, S.; Iinuma, M.; Matsuda, H.
Testosterone 5alpha-reductase inhibitory active constituents of Piper nigrum leaf
Biol. Pharm. Bull.
30
2402-2405
2007
Rattus norvegicus
McCarthy, A.R.; Hartmann, R.W.; Abell, A.D.
Evaluation of 4-substituted bicyclic pyridones as non-steroidal inhibitors of steroid 5alpha-reductase
Bioorg. Med. Chem. Lett.
17
3603-3607
2007
Homo sapiens
Hosoda, S.; Hashimoto, Y.
3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1
Bioorg. Med. Chem. Lett.
17
5414-5418
2007
Homo sapiens
Carneiro, M.M.; Morsch, D.M.; Camargos, A.F.; Reis, F.M.; Spritzer, P.M.
Androgen receptor and 5alpha-reductase are expressed in pelvic endometriosis
BJOG
115
113-117
2008
Homo sapiens
Appell, R.A.
Male lower urinary tract symptoms: treatment with alpha-blockers, 5-alpha-reductase inhibitors, antimuscarinics, or a combination
Curr. Urol. Rep.
8
370-372
2007
Homo sapiens
Onen, I.H.; Ekmekci, A.; Eroglu, M.; Polat, F.; Biri, H.
The association of 5alpha-reductase II (SRD5A2) and 17 hydroxylase (CYP17) gene polymorphisms with prostate cancer patients in the Turkish population
DNA Cell Biol.
26
100-107
2007
Homo sapiens
Cussenot, O.; Azzouzi, A.R.; Nicolaiew, N.; Mangin, P.; Cormier, L.; Fournier, G.; Valeri, A.; Cancel-Tassin, G.
Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors
Eur. Urol.
52
1082-1087
2007
Homo sapiens
Sanchez, P.; Torres, J.M.; Vilchez, P.; Del Moral, R.G.; Ortega, E.
Effects of sulpiride on mRNA levels of steroid 5alpha-reductase isozymes in prostate of adult rats
IUBMB Life
60
68-72
2008
Rattus norvegicus (P24008), Rattus norvegicus (P31214)
Baldinotti, F.; Majore, S.; Fogli, A.; Marrocco, G.; Ghirri, P.; Vuerich, M.; Tumini, S.; Boscherini, B.; Vetri, M.; Scommegna, S.; Rinaldi, R.; Simi, P.; Grammatico, P.
Molecular characterization of 6 unrelated Italian patients with 5alpha-reductase type 2 deficiency
J. Androl.
29
20-28
2008
Homo sapiens
Amory, J.K.; Wang, C.; Swerdloff, R.S.; Anawalt, B.D.; Matsumoto, A.M.; Bremner, W.J.; Walker, S.E.; Haberer, L.J.; Clark, R.V.
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men
J. Clin. Endocrinol. Metab.
92
1659-1665
2007
Homo sapiens
Bratoeff, E.; Sainz, T.; Cabeza, M.; Heuze, I.; Recillas, S.; Perez, V.; Rodriguez, C.; Segura, T.; Gonzales, J.; Ramirez, E.
Steroids with a carbamate function at C-17, a novel class of inhibitors for human and hamster steroid 5alpha-reductase
J. Steroid Biochem. Mol. Biol.
107
48-56
2007
Homo sapiens, Mesocricetus auratus
Serfling, R.; Shulman, M.; Thompson, G.L.; Xiao, Z.; Benaim, E.; Roehrborn, C.G.; Rittmaster, R.
Quantifying the impact of prostate volumes, number of biopsy cores and 5alpha-reductase inhibitor therapy on the probability of prostate cancer detection using mathematical modeling
J. Urol.
177
2352-2356
2007
Homo sapiens
Tindall, D.J.; Rittmaster, R.S.
The rationale for inhibiting 5alpha-reductase isoenzymes in the prevention and treatment of prostate cancer
J. Urol.
179
1235-1242
2008
Homo sapiens, Rattus norvegicus
Amory, J.K.; Anawalt, B.D.; Matsumoto, A.M.; Page, S.T.; Bremner, W.J.; Wang, C.; Swerdloff, R.S.; Clark, R.V.
The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men
J. Urol.
179
2333-2338
2008
Homo sapiens
Sanchez, P.; Torres, J.M.; Gavete, P.; Ortega, E.
Effects of swim stress on mRNA and protein levels of steroid 5alpha-reductase isozymes in prefrontal cortex of adult male rats
Neurochem. Int.
52
426-431
2008
Rattus norvegicus (P24008), Rattus norvegicus (P31214)
Assinder, S.J.
Oxytocin increases 5alpha -reductase activity of human prostate epithelial cells, but not stromal cells
Prostate
68
115-121
2008
Homo sapiens
Thevis, M.; Geyer, H.; Mareck, U.; Flenker, U.; Schaenzer, W.
Doping-control analysis of the 5alpha-reductase inhibitor finasteride: determination of its influence on urinary steroid profiles and detection of its major urinary metabolite
Ther. Drug Monit.
29
236-247
2007
Homo sapiens
Oliveira, O.L.; Koff, W.J.; Muraro, F.; Santos, E.B.; Gomes Soares, D.F.; Trindade, V.M.
Steroid 5-alpha reductase type 2 activity in biopsies from malignant and normal prostatic tissues
Clin. Chim. Acta
391
36-40
2008
Homo sapiens
Signorelli, S.S.; Barresi, V.; Musso, N.; Anzaldi, M.; Croce, E.; Fiore, V.; Condorelli, D.F.
Polymorphisms of steroid 5-alpha-reductase type I (SRD5A1) gene are associated to peripheral arterial disease
J. Endocrinol. Invest.
31
1092-1097
2008
Homo sapiens (P18405), Homo sapiens (P31213), Homo sapiens
Szcsi, M.; Ondr, D.; Tth, I.; Magony, S.; Wlfling, J.; Schneider, G.; Julesz, J.
Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
Acta Biol. Hung.
61
274-281
2010
Rattus norvegicus
Tanchuck, M.A.; Long, S.L.; Ford, M.M.; Hashimoto, J.; Crabbe, J.C.; Roselli, C.E.; Wiren, K.M.; Finn, D.A.
Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression
Alcohol. Clin. Exp. Res.
33
2077-2087
2009
Mus musculus
Walter, K.N.; Kienzle, F.B.; Frankenschmidt, A.; Hiort, O.; Wudy, S.A.; van der Werf-Grohmann, N.; Superti-Furga, A.; Schwab, K.O.
Difficulties in diagnosis and treatment of 5 alpha-reductase type 2 deficiency in a newborn with 46,XY DSD
Horm. Res. Paediatr.
74
67-71
2010
Homo sapiens (P31213)
Wang, X.; Liao, J.; Yin, D.; Zhan, F.; Dai, S.; Xie, G.; Sang, X.
Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type II 5alpha-reductase in vitro.
Yakugaku Zasshi
130
1207-1214
2010
Homo sapiens (P31213), Homo sapiens
Gillespie, C.; Almli, L.; Smith, A.; Bradley, B.; Kerley, K.; Crain, D.; Mercer, K.; Weiss, T.; Phifer, J.; Tang, Y.; Cubells, J.; Binder, E.; Conneely, K.; Ressler, K.
Sex dependent influence of a functional polymorphism in steroid 5-alpha-reductase type 2 (SRD5A2) on post-traumatic stress symptoms
Am. J. Med. Genet. B Neuropsychiatr. Genet.
162
283-292
2013
Homo sapiens (P31213)
Lin, S.F.; Lin, Y.H.; Lin, M.; Kao, Y.F.; Wang, R.W.; Teng, L.W.; Chuang, S.H.; Chang, J.M.; Yuan, T.T.; Fu, K.C.; Huang, K.P.; Lee, Y.S.; Chiang, C.C.; Yang, S.C.; Lai, C.L.; Liao, C.B.; Chen, P.; Lin, Y.S.; Lai, K.T.; Huang, H.J.; Yang, J.Y.; Liu, C.W.; Wei, W.Y.; Chen, C.K.; Hiipakka, R.A.; Liao, S.; Huang, J.J.
Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5?-reductase inhibitors
Eur. J. Med. Chem.
45
6068-6076
2010
Rattus norvegicus
Aggarwal, S.; Thareja, S.; Bhardwaj, T.R.; Haupenthal, J.; Hartmann, R.W.; Kumar, M.
Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5alpha-reductase inhibitors: a legitimate approach
Eur. J. Med. Chem.
54
728-739
2012
Homo sapiens (P18405), Homo sapiens (P31213)
Tesone, A.J.; Regueira, E.; Canosa, L.F.; Ceballos, N.R.
5alpha-Reductase, an enzyme regulating glucocorticoid action in the testis of Rhinella arenarum (Amphibia: Anura)
Gen. Comp. Endocrinol.
176
500-506
2012
Rhinella arenarum
Sanchez, P.; Torres, J.M.; del Moral, R.G.; de Dios Luna, J.; Ortega, E.
Steroid 5alpha-reductase in adult rat brain after neonatal testosterone administration
IUBMB Life
64
81-86
2012
Rattus norvegicus
Bae, M.; Woo, M.; Kusuma, I.W.; Arung, E.T.; Yang, C.H.; Kim, Y.U.
Inhibitory effects of isoflavonoids on rat prostate testosterone 5alpha-reductase
J. Acupunct. Meridian Stud.
5
319-322
2012
Rattus norvegicus
Murata, K.; Noguchi, K.; Kondo, M.; Onishi, M.; Watanabe, N.; Okamura, K.; Matsuda, H.
Inhibitory activities of Puerariae Flos against testosterone 5alpha-reductase and its hair growth promotion activities
J. Nat. Med.
66
158-165
2012
Rattus norvegicus
Lee, S.; Lee, D.; Lee, J.; Lee, W.; Chung, B.; Choi, M.
Comparative GC-MS based in vitro assays of 5alpha-reductase activity using rat liver S9 fraction
Mass Spectrom. Lett.
3
21-24
2012
Rattus norvegicus
-
Sanchez, P.; Torres, J.M.; Castro, B.; Del Moral, R.G.; de Dios Luna, J.; Ortega, E.
Steroid 5alpha-reductase in adult rat brain after neonatal dihydrotestosterone administration
Neurochem. Res.
38
557-563
2013
Rattus norvegicus (P24008), Rattus norvegicus (P31214)
Sharif, A.; Shoae-Hassani, A.; Sharif, S.; Banafshe, H.R.; Mortazavi-Tabatabaei, S.A.; Verdi, J.
5alpha-reductase 1 regulates spinal cord testosterone after morphine administration
Neurol. Sci.
34
19-23
2013
Rattus norvegicus
Murata, K.; Takeshita, F.; Samukawa, K.; Tani, T.; Matsuda, H.
Effects of ginseng rhizome and ginsenoside Ro on testosterone 5alpha-reductase and hair re-growth in testosterone-treated mice
Phytother. Res.
26
48-53
2012
Mus musculus, Rattus norvegicus
Li, J.; Ding, Z.; Wang, Z.; Lu, J.F.; Maity, S.N.; Navone, N.M.; Logothetis, C.J.; Mills, G.B.; Kim, J.
Androgen regulation of 5alpha-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention
PLoS ONE
6
e28840
2011
Homo sapiens, Homo sapiens (P31213), Homo sapiens (Q9H8P0)
Arellano, Y.; Bratoeff, E.; Garrido, M.; Soriano, J.; Heuze, Y.; Cabeza, M.
New ester derivatives of dehydroepiandrosterone as 5alpha-reductase inhibitors
Steroids
76
1241-1246
2011
Homo sapiens
Srivilai, J.; Rabgay, K.; Khorana, N.; Waranuch, N.; Nuengchamnong, N.; Wisuitiprot, W.; Chuprajob, T.; Changtam, C.; Suksamrarn, A.; Chavasiri, W.; Sornkaew, N.; Ingkaninan, K.
Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors
Med. Chem. Res.
26
1550-1556
2017
Homo sapiens, Homo sapiens CRL-1740
-
Srivilai, J.; Rabgay, K.; Khorana, N.; Waranuch, N.; Nuengchamnong, N.; Wisuitiprot, W.; Chuprajob, T.; Changtam, C.; Suksamrarn, A.; Chavasiri, W.; Sornkaew, N.; Ingkaninan, K.
Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors
Med. Chem. Res.
26
1550-1556
2017
Homo sapiens, Homo sapiens CRL-1740
-
Wu, Y.; Li, L.; Zhou, S.; Shen, Q.; Lin, H.; Zhu, Q.; Sun, J.; Ge, R.S.
Apigenin inhibits rat neurosteroidogenic 5alpha-reductase 1 and 3alpha-hydroxysteroid dehydrogenase
Neurochem. Int.
110
84-90
2017
Rattus norvegicus (P24008)
Guo, J.; Li, L.; Zhou, S.; Su, Y.; Li, X.; Sun, J.; Ge, R.S.
Butylated hydroxyanisole alters rat 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase Implications for influences of neurosteroidogenesis
Neurosci. Lett.
653
132-138
2017
Rattus norvegicus (P24008)
Karnsomwan, W.; Netcharoensirisuk, P.; Rungrotmongkol, T.; De-Eknamkul, W.; Chamni, S.
Synthesis, biological evaluation and molecular docking of avicequinone C analogues as potential steroid 5alpha-reductase inhibitors
Chem. Pharm. Bull.
65
253-260
2017
Homo sapiens
Peng, H.M.; Valentin-Goyco, J.; Im, S.C.; Han, B.; Liu, J.; Qiao, J.; Auchus, R.J.
Expression in Escherichia Coli, purification, and functional reconstitution of human steroid 5alpha-reductases
Endocrinology
161
bqaa117
2020
Homo sapiens (P18405), Homo sapiens (P31213)
Gent, R.; du Toit, T.; Swart, A.C.
11alpha-Hydroxyprogesterone, a potent 11alpha-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5alpha-reductase and cytochrome P450 17alpha-hydroxylase/17,20-lyase to produce C11alpha-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro
J. Steroid Biochem. Mol. Biol.
191
105369
2019
Homo sapiens (P18405), Homo sapiens (P31213)
Xiao, Q.; Wang, L.; Supekar, S.; Shen, T.; Liu, H.; Ye, F.; Huang, J.; Fan, H.; Wei, Z.; Zhang, C.
Structure of human steroid 5alpha-reductase 2 with the anti-androgen drug finasteride
Nat. Commun.
11
5430
2020
Homo sapiens (P31213)
Han, Y.; Zhuang, Q.; Sun, B.; Lv, W.; Wang, S.; Xiao, Q.; Pang, B.; Zhou, Y.; Wang, F.; Chi, P.; Wang, Q.; Li, Z.; Zhu, L.; Li, F.; Deng, D.; Chiang, Y.; Li, Z.; Ren, R.
Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism
Nat. Commun.
12
449
2021
Proteobacteria bacterium (A0A3A0FWV3)
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