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Reference on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Traut, T.W.; Loechel, S.
Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay
Biochemistry
23
2533-2539
1984
Rattus norvegicus
Manually annotated by BRENDA team
Wasternack, C.; Lippmann, G.; Reinbotte, H.
Pyrimidine-degrading enzymes purification and properties of beta-ureidopropionase of Euglena gracilis
Biochim. Biophys. Acta
570
341-351
1979
Euglena gracilis
Automatic Mining of ENzyme DAta
Hallock, R.O.; Yamada, E.W.
Pyrimidine reducing enzymes of rat liver
Can. J. Biochem.
54
178-184
1976
BRENDA: Rattus norvegicus
Textmining: Rattus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Haaz, M.C.; Fischel, J.L.; Formento, P.; Renee, N.; Etienne, M.C.; Milano, G.
Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase
Cancer Chemother. Pharmacol.
38
52-58
1996
Homo sapiens
Manually annotated by BRENDA team
Milano, G.; Fischel, J.L.; Etienne, M.C.; Renee, N.; Formento, P.; Thyss, A.; Gaspard, M.H.; Thill, L.; Cupissol, D.
Inhibition of dihydropyrimidine dehydrogenase by alpha-interferon: Experimental data on human tumor cell lines
Cancer Chemother. Pharmacol.
34
147-152
1994
Homo sapiens
Manually annotated by BRENDA team
Fritzson, P.
Properties and assay of dihydrouracil dehydrogenase of rat liver
J. Biol. Chem.
235
719-725
1960
BRENDA: Rattus norvegicus
Textmining: Rattus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Grisolia, S.; Cardoso, S.S.
The purification and properties of hydropyrimidine dehydrogenase
Biochim. Biophys. Acta
25
430-431
1957
Bos taurus
Manually annotated by BRENDA team
Shiotani, T.; Weber, G.
Purification and properties of dihydrothymine dehydrogenase from rat liver
J. Biol. Chem.
256
219-224
1981
Rattus norvegicus
Manually annotated by BRENDA team
Tuchman, M.; Roemeling, R.V.; Hrushesky, W.A.M.; Sothern, R.B.; O'Dea, R.F.
Dihydropyrimidine dehydrogenase activity in human blood mononuclear cells
Enzyme
42
15-24
1989
Homo sapiens
Manually annotated by BRENDA team
Klein, C.M.; Haas, H.J.
New high-performance liquid chromatographic method for the determination of low activities of dihydropyrimidine dehydrogenase
J. Chromatogr.
529
431-436
1990
Rattus norvegicus
Manually annotated by BRENDA team
Porter, D.J.T.; Chestnut, W.G.; Merrill, B.M.; Spector, T.
Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil
J. Biol. Chem.
267
5236-5242
1992
BRENDA: Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Textmining: Rattus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Podschun, B.; Wahler, G.; Schnackerz, K.D.
Purification and characterization of dihydropyrimidine dehydrogenase from pig liver
Eur. J. Biochem.
185
219-224
1989
Sus scrofa
Manually annotated by BRENDA team
Podschun, B.; Cook, P.F.; Schnackerz, K.D.
Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver
J. Biol. Chem.
265
12966-12972
1990
Sus scrofa
Manually annotated by BRENDA team
Podschun, B.
Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver
Biochem. Biophys. Res. Commun.
182
609-616
1992
Sus scrofa
Manually annotated by BRENDA team
Porter, D.J.T.; Chestnut, W.G.; Taylor, L.C.E.; Merrill, B.M.; Spector, T.
Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil
J. Biol. Chem.
266
19988-19994
1991
Bos taurus
Manually annotated by BRENDA team
Balzarini, J.; Sienaert, R.; Liekens, S.; Van Kuilenburg, A.; Carangio, A.; Esnouf, R.; De Clercq, E.; McGuigan, C.
Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase
Mol. Pharmacol.
61
1140-1145
2002
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Schmitt, U.; Jahnke, K.; Rosenbaum, K.; Cook, P.F.; Schnackerz, K.D.
Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus
Arch. Biochem. Biophys.
332
175-182
1996
Cupriavidus necator
Manually annotated by BRENDA team
Goudgaon, N.M.; Naguib, F.N.M.; el Kouni, M.H.; Schinazi, R.F.
Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase
J. Med. Chem.
36
4250-4254
1993
BRENDA: Mus musculus
Textmining: Homo sapiens
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Naguib, F.N.M.; El Kouni, M.H.; Cha, S.
Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver
Biochem. Pharmacol.
38
1471-1480
1989
BRENDA: Mus musculus
Textmining: Homo sapiens
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Rosenbaum, K.; Jahnke, K.; Curti, B.; Hagen, W.R.; Schnackerz, K.D.; Vanoni, M.A.
Porcine Recombinant Dihydropyrimidine Dehydrogenase: Comparison of the spectroscopic and catalytic properties of the wild-type and C671A mutant enzymes
Biochemistry
37
17598-17609
1998
Sus scrofa
Manually annotated by BRENDA team
Lu, Z.H.; Zhang, R.; Diasio, R.B.
Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties
Biochem. Pharmacol.
46
945-952
1993
BRENDA: Bos taurus, Homo sapiens, Rattus norvegicus, Sus scrofa
Textmining: Rattus, Oryctolagus cuniculus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Rosenbaum, K.; Schaffrath, B.; Hagen, W.R.; Jahnke, K.; Gonzalez, F.J.; Cook, P.F.; Schnackerz, K.D.
Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase
Protein Expr. Purif.
10
185-191
1997
Sus scrofa
Manually annotated by BRENDA team
Van Kuilenburg, A.B.P.; Van Lenthe, H.; Wanders, R.J.A.; Van Gennip, A.H.
Subcellular localization of dihydropyrimidine dehydrogenase
Biol. Chem.
378
1047-1053
1997
Rattus norvegicus
Manually annotated by BRENDA team
Hagen, W.R.; Vanoni, M.A.; Rosenbaum, K.; Schnackerz, K.D.
On the iron-sulfur clusters in the complex redox enzyme dihydropyrimidine dehydrogenase
Eur. J. Biochem.
267
3640-3646
2000
Sus scrofa
Manually annotated by BRENDA team
Dobritzsch, D.; Ricagno, S.; Schneider, G.; Schnackerz, K.D.; Lindqvist, Y.
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer
J. Biol. Chem.
277
13155-13166
2002
Sus scrofa
Manually annotated by BRENDA team
Porter, D.J.T.; Spector, T.
Dihydropyrimidine dehydrogenase. Kinetic mechanism for reduction of uracil by NADPH
J. Biol. Chem.
268
19321-19327
1993
Bos taurus
Manually annotated by BRENDA team
Podschun, B.; Jahnke, K.; Schnackerz, K.D.; Cook, P.F.
Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies
J. Biol. Chem.
268
3407-3413
1993
Sus scrofa
Manually annotated by BRENDA team
Van Kuilenburg, A.B.P.; Dobritzsch, D.; Meinsma, R.; Haasjes, J.; Waterham, H.R.; Nowaczyk, M.J.M.; Maropoulos, G.D.; Hein, G.; Kalhoff, H.; Kirk, J.M.; Baaske, H.; Aukett, A.; Duley, J.A.; Ward, K.P.; Lindqvist, Y.; Van Gennip, A.H.
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure
Biochem. J.
364
157-163
2002
Homo sapiens
Manually annotated by BRENDA team
Schnackerz, K.D.; Dobritzsch, D.; Lindqvist, Y.; Cook, P.F.
Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters
Biochim. Biophys. Acta
1701
61-74
2004
Cupriavidus necator, Bos taurus, Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Mattison, L.K.; Johnson, M.R.; Diasio, R.B.
A comparative analysis of translated dihydropyrimidine dehydrogenase cDNA; conservation of functional domains and relevance to genetic polymorphisms
Pharmacogenetics
12
133-144
2002
Mus musculus
Manually annotated by BRENDA team
Di Paolo, A.; Danesi, R.; Ciofi, L.; Vannozzi, F.; Bocci, G.; Lastella, M.; Amatori, F.; Martelloni, B.M.; Ibrahim, T.; Amadori, D.; Falcone, A.; Del Tacca, M.
Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling
Ther. Drug Monit.
27
362-368
2005
Homo sapiens
Manually annotated by BRENDA team
Van Kuilenburg, A.B.; Meinsma, R.; Beke, E.; Bobba, B.; Boffi, P.; Enns, G.M.; Witt, D.R.; Dobritzsch, D.
Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function
Biol. Chem.
386
319-324
2005
Sus scrofa, Homo sapiens (Q12882)
Manually annotated by BRENDA team
Ogura, K.; Ohnuma, T.; Minamide, Y.; Mizuno, A.; Nishiyama, T.; Nagashima, S.; Kanamaru, M.; Hiratsuka, A.; Watabe, T.; Uematsu, T.
Dihydropyrimidine dehydrogenase activity in 150 healthy Japanese volunteers and identification of novel mutations
Clin. Cancer Res.
11
5104-5111
2005
Homo sapiens
Manually annotated by BRENDA team
Mattison, L.; Fourie, J.; Hirao, Y.; Koga, T.; Desmond, R.A.; King, J.R.; Shimizu, T.; Diasio, R.B.
The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil
Clin. Cancer Res.
12
549-555
2006
Homo sapiens
Manually annotated by BRENDA team
West, T.P.
Pyrimidine base catabolism in Pseudomonas putida biotype B
Antonie van Leeuwenhoek
80
163-167
2001
Pseudomonas putida
Manually annotated by BRENDA team
van Kuilenburg, A.B.; Meijer, J.; Dobritzsch, D.; Lohkamp, B.; Ruitenbeek, W.; Roelofsen, J.; Abeling, N.G.; Duran, M.; Buzing, C.
Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria
Nucleosides Nucleotides Nucleic Acids
27
809-815
2008
Homo sapiens
Manually annotated by BRENDA team
Zrenner, R.; Riegler, H.; Marquard, C.R.; Lange, P.R.; Geserick, C.; Bartosz, C.E.; Chen, C.T.; Slocum, R.D.
A functional analysis of the pyrimidine catabolic pathway in Arabidopsis
New Phytol.
183
117-132
2009
Arabidopsis
Automatic Mining of ENzyme DAta
Tsuchida, M.; Yamato, Y.; Hashimoto, T.; Shinohara, H.; Umezu, H.; Yoshiya, K.; Koike, T.; Hayashi, J.
Expression of 5-fluorouracil-related enzymes in lung cancer: ELISA characterizes enzyme activity and messenger RNA expression
Oncol. Rep.
21
1037-1043
2009
Homo sapiens
Manually annotated by BRENDA team
Lohkamp, B.; Voevodskaya, N.; Lindqvist, Y.; Dobritzsch, D.
Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination
Biochim. Biophys. Acta
1804
2198-2206
2010
Sus scrofa (Q28943)
Manually annotated by BRENDA team
Serve, K.M.; Darnell, J.L.; Takemoto, J.K.; Davies, N.M.; Black, M.E.
Validation of an isocratic HPLC method to detect 2-fluoro-beta-alanine for the analysis of dihydropyrimidine dehydrogenase activity
J. Chromatogr. B
878
1889-1892
2010
Homo sapiens
Manually annotated by BRENDA team
Danielyan, K.E.
Dependence of cell survival on correlative activities of xanthine oxidase and dihydopyrimidine dehydrogenase in human brain-derived cell culture
Cent. Nerv. Syst. Agents Med. Chem.
13
108-113
2013
Homo sapiens
Manually annotated by BRENDA team
Liu, X.Q.; Zhuang, M.; Wang, Z.; Huber, R.M.
Correlation between dihydropyrimidine dehydrogenase and efficacy and toxicity of fluoropyrimidine drugs
Eur. Rev. Med. Pharmacol. Sci.
18
2772-2776
2014
Homo sapiens
Manually annotated by BRENDA team
Camadan, Y.; Oezdemir, H.; Gulcin, I.
Purification and characterization of dihydropyrimidine dehydrogenase enzyme from sheep liver and determination of the effects of some anaesthetic and antidepressant drugs on the enzyme activity
J. Enzyme Inhib. Med. Chem.
31
1335-1341
2016
Ovis aries
Manually annotated by BRENDA team
Tekdal, D.; Lucas, S.; Cetiner, S.
First report about the identification and preliminary analysis of a partial sequence of dihydropyrimidine dehydrogenase (NADP+) in Thermopsis turcica during floral development using degenerate primers
Acta Physiol. Plant.
39
159
2017
Vuralia turcica (A0A0U4C530)
-
Manually annotated by BRENDA team
Beaupre, B.A.; Forouzesh, D.C.; Moran, G.R.
Transient-state analysis of porcine dihydropyrimidine dehydrogenase reveals reductive activation by NADPH
Biochemistry
59
2419-2431
2020
Sus scrofa (Q28943)
Manually annotated by BRENDA team
Forouzesh, D.C.; Beaupre, B.A.; Butrin, A.; Wawrzak, Z.; Liu, D.; Moran, G.R.
The interaction of porcine dihydropyrimidine dehydrogenase with the chemotherapy sensitizer 5-ethynyluracil
Biochemistry
60
1120-1132
2021
Sus scrofa (Q28943)
Manually annotated by BRENDA team
Beaupre, B.A.; Forouzesh, D.C.; Butrin, A.; Liu, D.; Moran, G.R.
Perturbing the movement of hydrogens to delineate and assign events in the reductive activation and turnover of porcine dihydropyrimidine dehydrogenase
Biochemistry
60
1764-1775
2021
Sus scrofa (Q28943)
Manually annotated by BRENDA team
Shestopal, SA; Johnson, MR; Diasio, RB
Molecular cloning and characterization of the human dihydropyrimidine dehydrogenase promoter.
Biochim Biophys Acta
1494
162-9
2000
Homo sapiens
Automatic Mining of ENzyme DAta
Ho, DH; Townsend, L; Luna, MA; Bodey, GP
Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate.
Anticancer Res
6
781-4
0
Homo sapiens
Automatic Mining of ENzyme DAta
Smith, AE; Yamada, EW
Dihydrouracil dehydrogenase of rat liver. Separation of hydrogenase and dehydrogenase activities.
J Biol Chem
246
3610-7
1971
Rattus
Automatic Mining of ENzyme DAta
Naguib, FN; Soong, SJ; el Kouni, MH
Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver. Possible relevance to chemotherapy with 5-fluoropyrimidines.
Biochem Pharmacol
45
667-73
1993
Mus musculus, Mus sp.
Automatic Mining of ENzyme DAta
Ashour, OM; Naguib, FN; Goudgaon, NM; Schinazi, RF; el Kouni, MH
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Biochem Pharmacol
60
687-92
2000
Mus musculus, Homo sapiens, Mus sp.
Automatic Mining of ENzyme DAta
Tamaki, N; Fujimoto, S; Mizota, C; Kaneko, M; Kikugawa, M
Inhibitory effect of 6-azauracil on beta-alanine metabolism in rat.
J Nutr Sci Vitaminol (Tokyo)
35
451-61
1989
Rattus
Automatic Mining of ENzyme DAta
Naguib, FN; el Kouni, MH; Cha, S
Enzymes of uracil catabolism in normal and neoplastic human tissues.
Cancer Res
45
5405-12
1985
Homo sapiens
Automatic Mining of ENzyme DAta
Wettergren, Y; Carlsson, G; Odin, E; Gustavsson, B
Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-flurorouracil-based chemotherapy.
Cancer
2011
Homo sapiens
Automatic Mining of ENzyme DAta
Shiotani, T; Hashimoto, Y; Tanaka, T; Irino, S
Behavior of activities of thymidine metabolizing enzymes in human leukemia-lymphoma cells.
Cancer Res
49
1090-4
1989
Homo sapiens
Automatic Mining of ENzyme DAta
Piper, AA; Tattersall, MH; Fox, RM
The activities of thymidine metabolising enzymes during the cell cycle of a human lymphocyte cell line LAZ-007 synchronised by centrifugal elutriation.
Biochim Biophys Acta
633
400-9
1980
Homo sapiens
Automatic Mining of ENzyme DAta
Berglund, G; Greter, J; Lindstedt, S; Steen, G; Waldenström, J; Wass, U
Urinary excretion of thymine and uracil in a two-year-old child with a malignant tumor of the brain.
Clin Chem
25
1325-8
1979
Homo sapiens
Automatic Mining of ENzyme DAta
Naguib, FN; Niedzwicki, JG; Iltzsch, MH; Wiemann, MC; el Kouni, MH; Cha, SM
Effects of N,N-dimethylformamide and sodium butyrate on enzymes of pyrimidine metabolism in cultured human tumor cells.
Leuk Res
11
855-61
1987
Homo sapiens
Automatic Mining of ENzyme DAta
Keizer, HJ; De Bruijn, EA; Tjaden, UR; De Clercq, E
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
J Cancer Res Clin Oncol
120
545-9
1994
Human alphaherpesvirus 1, Human alphaherpesvirus 3
Automatic Mining of ENzyme DAta
Okajima, K; Yamamoto, T; Suchi, M; Wada, Y
A screening method for dihydropyrimidine dehydrogenase deficiency with colorimetric detection of urinary uracil.
Adv Exp Med Biol
253A
119-22
1989
Homo sapiens
Automatic Mining of ENzyme DAta
Porter, DJ; Harrington, JA; Almond, MR; Lowen, GT; Zimmerman, TP; Spector, T
5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase.
Biochem Pharmacol
47
1165-71
1994
Rattus
Automatic Mining of ENzyme DAta
Spector, T; Harrington, JA; Porter, DJ
5-Ethynyluracil (776C85): inactivation of dihydropyrimidine dehydrogenase in vivo.
Biochem Pharmacol
46
2243-8
1993
Homo sapiens, Mus musculus, Rattus
Automatic Mining of ENzyme DAta
Johnson, MR; Wang, K; Diasio, RB
Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.
Clin Cancer Res
8
768-74
2002
Alabama, Homo sapiens
Automatic Mining of ENzyme DAta
Ogura, K
[Dihydropyrimidine dehydrogenase activity and its genetic aberrations]
Gan To Kagaku Ryoho
33
1041-8
2006
Homo sapiens
Automatic Mining of ENzyme DAta
Serdar, MA; Serto?lu, E; Uyan?k, M; Tapan, S; Ak?n, O; Cihan, M
Determination of 5-fluorouracil and dihydrofluorouracil levels by using a liquid chromatography-tandem mass spectrometry method for evaluation of dihydropyrimidine dehydrogenase enzyme activity.
Cancer Chemother Pharmacol
2010
Homo sapiens
Automatic Mining of ENzyme DAta
Naguib, FN; Hao, SN; el Kouni, MH
Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5-benzyloxybenzyluracil.
Cancer Res
54
5166-70
1994
Homo sapiens, Metazoa, Mus sp.
Automatic Mining of ENzyme DAta
Tatsumi, K; Yamauchi, T; Kiyono, K; Kishi, K; Yanagihara, Y; Imaoka, T; Kawaguchi, T; Kubo, M
3-Cyano-2,6-dihydroxypyridine (CNDP), a new potent inhibitor of dihydrouracil dehydrogenase.
J Biochem (Tokyo)
114
912-8
1993
Rattus
Automatic Mining of ENzyme DAta
Naguib, FN; Levesque, DL; Wang, EC; Panzica, RP; el Kouni, MH
5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase.
Biochem Pharmacol
46
1273-83
1993
Homo sapiens, Mus musculus
Automatic Mining of ENzyme DAta
el Kouni, MH; Goudgaon, NM; Rafeeq, M; Al Safarjalani, ON; Schinazi, RF; Naguib, FN
5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase.
Biochem Pharmacol
60
851-6
2000
Homo sapiens, Mus musculus
Automatic Mining of ENzyme DAta
Baccanari, DP; Davis, ST; Knick, VC; Spector, T
5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil.
Proc Natl Acad Sci U S A
90
11064-8
1993
Mus musculus, Mus sp., Rattus
Automatic Mining of ENzyme DAta
Zhang, R; Lu, Z; Liu, T; Soong, SJ; Diasio, RB
Relationship between circadian-dependent toxicity of 5-fluorodeoxyuridine and circadian rhythms of pyrimidine enzymes: possible relevance to fluoropyrimidine chemotherapy.
Cancer Res
53
2816-22
1993
Homo sapiens, Rattus, Metazoa
Automatic Mining of ENzyme DAta
Johnson, MR; Hageboutros, A; Wang, K; High, L; Smith, JB; Diasio, RB
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.
Clin Cancer Res
5
2006-11
1999
Homo sapiens
Automatic Mining of ENzyme DAta
McLeod, HL; Milne, LH; Johnston, SJ
5-Fluorouracil metabolizing enzymes.
Methods Mol Med
28
111-20
1999
Mus sp.
Automatic Mining of ENzyme DAta
Shirasaka, T; Shimamato, Y; Ohshimo, H; Yamaguchi, M; Kato, T; Yonekura, K; Fukushima, M
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
Anticancer Drugs
7
548-57
1996
Rattus, Homo sapiens
Automatic Mining of ENzyme DAta