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2,4-dihydroxybenzaldehyde + H2O + O2
2,4-dihydroxybenzoate + H2O2
-
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
4-(dimethylamino)cinnamic acid + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
-
-
?
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
-
-
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
-
-
-
?
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoate + H2O2
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
butanal + H2O + O2
butanoic acid + H2O2
-
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
-
-
-
?
ethyl vanillin + H2O + O2
ethyl vanillic acid + H2O2
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
octanal + H2O + O2
octanoic acid + H2O2
-
-
-
?
pentanal + H2O + O2
pentanoic acid + H2O2
-
-
-
?
phenanthridine + H2O + O2
phenanthridinone + H2O2
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
-
-
?
phenylpropionaldehyde + H2O + O2
phenylpropionic acid + H2O2
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
?
purine + O2 + H2O
? + H2O2
-
-
-
?
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
vanillin + H2O + O2
vanillic acid + H2O2
2,4-dihydroxybenzaldehyde + H2O + O2
2,4-dihydroxybenzoate + H2O2
-
-
-
?
2-hydroxypyrimidine + ferricyanide
?
-
-
-
-
?
2-hydroxypyrimidine + H2O + ferricyanide + O2
?
-
-
-
-
?
2-hydroxypyrimidine + H2O + O2
uracil + H2O2
-
-
-
-
?
2-hydroxypyrimidine + O2 + H2O
?
-
-
-
-
?
2-methoxybenzaldehyde + H2O + O2
2-methoxybenzoate + H2O2
-
-
-
?
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol + H2O + O2
? + H2O2
-
-
-
-
?
3-methoxybenzaldehyde + H2O + O2
3-methoxybenzoate + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + H2O + O2
4-(dimethylamino)cinnamic acid + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
4-hydroxybenzaldehyde + H2O + O2
4-hydroxybenzoate + H2O2
-
-
-
?
4-methoxybenzaldehyde + H2O + O2
4-methoxybenzoate + H2O2
-
-
-
?
4-nitrobenzaldehyde + H2O + O2
4-nitrobenzoate + H2O2
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine + H2O + O2
? + H2O2
-
-
-
-
?
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline + H2O + O2
? + H2O2
-
-
-
-
?
acetaldehyde + 2 ferricyanide + H2O
acetate + 2 ferrocyanide + 2 H+
-
-
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
acetaldehyde + H2O + O2
acetic acid + H2O2
acetophenone oxime + H2O + 2-hydroxypyrimidine
acetophenone + NH3
-
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
all-trans-retinal + O2 + H2O
all-trans-retinoate + H2O2
-
-
-
-
?
allopurinol + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
benzaldehyde + 2 ferricyanide + H2O
benzoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
benzaldehyde + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
benzaldehyde + H2O + 2,6-dichlorophenolindophenol
benzoate + reduced 2,6-dichlorophenolindophenol
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
benzaldehyde + H2O + O2
benzoic acid + H2O2
-
-
-
-
?
benzaldehyde + O2 + H2O
benzoate + H2O2
-
-
-
-
?
butanal + 2 ferricyanide + H2O
butanoate + 2 ferrocyanide + 2 H+
-
-
-
-
?
butanal + H2O + O2
butanoic acid + H2O2
-
-
-
?
cinnamaldehyde + H2O + O2
cinnamic acid + H2O2
-
-
-
?
crotonaldehyde + H2O + O2
crotonate + H2O2
-
-
-
?
electron donor + nicotinamide N-oxide
nicotinamide + electron acceptor
-
2-hydroxypyrimidine as electron acceptor
-
-
?
ethyl vanillin + H2O + O2
ethyl vanillic acid + H2O2
-
-
-
?
heptanal + H2O + O2
heptanoic acid + H2O2
-
-
-
?
hexanal + H2O + O2
hexanoic acid + H2O2
-
-
-
?
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide + H2O + O2
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
-
-
-
?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide-9-(10H)-acridone + H2O2
-
antitumor drug
-
-
?
N1-methyl-nicotineamide + H2O + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
N1-methylnicotinamide + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
octanal + H2O + O2
octanoic acid + H2O2
-
-
-
?
octylaldehyde + O2 + H2O
octanoate + H2O2
-
-
-
-
?
pentanal + H2O + O2
pentanoic acid + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
phenanthridine + H2O + O2
?
-
-
-
?
phenanthridine + H2O + O2
phenanthridinone + H2O2
-
-
-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
-
-
-
?
phenylpropionaldehyde + H2O + O2
phenylpropionic acid + H2O2
-
-
-
?
phthalazine + 2,6-dichlorophenol indophenol
?
natural electron acceptor of enzyme is molecular oxygen, DCPIP i.e., 2,6-dichlorophenol indophenol
-
-
?
phthalazine + ferricyanide
1-phthalazinone + ferrocyanide
-
-
-
-
?
phthalazine + ferricyanide
?
-
-
-
-
?
phthalazine + H2O + 2,6-dichlorophenol indophenol
? + reduced 2,6-dichlorophenolindophenol
-
-
-
?
phthalazine + H2O + O2
1-phthalazinone + H2O2
-
-
-
?
phthalazine + H2O + O2
? + H2O2
-
-
-
?
phthalazine + O2 + H2O
1-phthalazinone + H2O2
-
-
-
-
?
propionaldehyde + H2O + O2
propionic acid + H2O2
-
-
-
?
purine + O2 + H2O
? + H2O2
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
retinal + O2 + H2O
retinoate + H2O2
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
retinaldehyde + O2 + H2O
retinoic acid + H2O2
salicylaldehyde + H2O + O2
salicylic acid + H2O2
vanillin + H2O + O2
vanillic acid + H2O2
zebularine + H2O + O2
uridine + H2O2
-
-
major catabolic route for oral antitumor agent zebularine
-
?
additional information
?
-
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
-
-
?
4-(dimethylamino)cinnamaldehyde + O2 + H2O
4-(dimethylamine)cinnamate + H2O2
-
typical substrate spectrum of aldehyde oxidase
-
?
acetaldehyde + H2O + O2
acetate + H2O2
is a poor substrate of AOH1
-
-
?
acetaldehyde + H2O + O2
acetate + H2O2
is a poor substrate of AOX1
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
acetaldehyde + H2O + O2
acetic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
-
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
AOH1 from the liver of CD1 mice is capable of oxidizing all-trans retinaldehyde
-
-
?
all-trans retinaldehyde + H2O + O2
all-trans retinoic acid + H2O2
AOH2 from the mouse Harderian gland and AOH3 from the mouse Bowman's gland are all capable of oxidizing all-trans retinaldehyde with equal efficiency
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
benzaldehyde + H2O + O2
benzoate + H2O2
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
-
?
N1-methylnicotinamide + H2O + O2
N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
-
-
-
?
phenanthridine + H2O + O2
6-phenanthridone + H2O2
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
-
-
-
-
?
pyridoxal + H2O + O2
4-pyridoxic acid + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
-
-
?
retinal + O2 + H2O
retinoate + H2O2
-
-
-
?
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
-
?
retinalaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
-
?
retinaldehyde + O2 + H2O
retinoic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
salicylaldehyde + H2O + O2
salicylic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
vanillin + H2O + O2
vanillic acid + H2O2
-
-
-
?
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
-
no substrate for isoform AOX2: pyridoxal
-
-
-
additional information
?
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
enzyme plays an important role in the biotransformation of drugs and xenobiotics, e.g. antiviral, antimalarial and antitumour compounds and nicotine
-
-
?
additional information
?
-
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
pyridoxal is not recognized by mouse AOH2
-
-
?
additional information
?
-
no substrate: xanthine, hypoxanthine
-
-
?
additional information
?
-
-
no substrate: xanthine, hypoxanthine
-
-
?
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
-
no substrate for isoform AOX3: pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
no substrates for isoform AOX1: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
additional information
?
-
-
no substrates for isoform AOX4: N1-methylnicotinamide, pyridoxal
-
-
-
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aspartate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
estrogen
reduces liver aldehyde oxidase activity of male animals
glutamate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
5-benzylacyclouridine
-
50% inhibition at about 0.8 mM
Amytal
-
48% inhibition at 0.2 mM
aspartate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
beta-carboline
a far better inhibitor of mouse AOH1 than AOX1
beta-estradiol
-
51% inhibition at 0.004 mM
estrogen
reduces liver aldehyde oxidase activity of male animals
fenofibrate
-
in mature adipocytes, enzyme expression is reduced in presence of 50 microM fenofibrate
glutamate
neonatal pretreatment, which reduces circulating growth hormone levels, decreases male aldehyde oxidase activity to female levels
norharman
-
slight inhibition at 0.02 mM
palmitic acid
-
enzyme expression is reduced in 3T3-L1 cells differentiated in presence of 400 microM palmitic acid
Quinacrine
-
45% inhibition at 0.002 mM
SKF 525-A
-
60% inhibition at 0.05 mM
benzamidine
-
benzamidine
-
1 mM, 58% inhibition
benzamidine
-
75% inhibition at 0.1 mM
menadione
-
menadione
-
0.005 mM, 87% inhibition
menadione
-
slight inhibition at 0.005 mM
menadione
-
0.005 mM, 74% inhibition
menadione
-
0.006 mM, 0.0042 mM, 0.0026 mM, 0.001 mM, 0.0014 mM and 0.0008 mM, 50% inhibition of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide oxidation in male swiss CD mouse, CB57BI/6J, female swiss CD mouse, nude mouse, nude mouse tumor bearing and C129/C57 muse, respectively
norharmane
-
norharmane
-
0.02 mM, 87% inhibition
raloxifene
-
raloxifene
-
50% inhibition at about 500 nM
additional information
-
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
-
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
additional information
activity is significantly reduced by castration of adult males. Hypophysectomy markedly decreases hepatic activity in male and to a lesser extent in female mice
-
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0.0145
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.0006
2-Methoxybenzaldehyde
pH 8, 37°C
0.0019
3-Methoxybenzaldehyde
pH 8, 37°C
0.0004
4-(dimethylamino)cinnamaldehyde
0.0027
4-hydroxybenzaldehyde
pH 8, 37°C
0.0012
4-methoxybenzaldehyde
pH 8, 37°C
0.0105
4-nitrobenzaldehyde
pH 8, 37°C
4.375
acetaldehyde
pH 8, 37°C
0.0052
benzaldehyde
pH 8, 37°C
0.0989
Butanal
pH 8, 37°C
0.0012
cinnamaldehyde
pH 8, 37°C
0.0848
crotonaldehyde
pH 8, 37°C
0.0027
ethyl vanillin
pH 8, 37°C
0.013
Heptanal
pH 8, 37°C
0.0103
hexanal
pH 8, 37°C
0.0094
N1-methylnicotinamide
pH 8, 37°C
0.0094
octanal
pH 8, 37°C
0.0157
pentanal
pH 8, 37°C
0.0019
phenanthridine
pH 8, 37°C
0.0513
phenylacetaldehyde
pH 8, 37°C
0.1224
phenylpropionaldehyde
pH 8, 37°C
0.0018
Phthalazine
pH 8, 37°C
0.2984
propionaldehyde
pH 8, 37°C
0.0264
retinalaldehyde
pH 8, 37°C
0.0021 - 0.2525
2,4-dihydroxybenzaldehyde
0.06 - 14.7
2-hydroxypyrimidine
0.0066 - 0.0194
2-Methoxybenzaldehyde
0.0024
2-[(6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinolin-3-yl)amino]ethan-1-ol
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0084 - 0.0201
3-Methoxybenzaldehyde
0.0005 - 0.0033
4-(dimethylamino)cinnamaldehyde
0.0019 - 0.0346
4-hydroxybenzaldehyde
0.0118 - 0.0234
4-methoxybenzaldehyde
0.0013 - 0.0176
4-nitrobenzaldehyde
0.0017
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxetan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.001
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-(oxolan-3-yl)quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.0024
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-N-[(oxolan-3-yl)methyl]quinolin-3-amine
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.038
6-[[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]quinoline
-
liver cytosol, pH not specified in the publication, temperature not specified in the publication
-
0.5199 - 52.9
acetaldehyde
0.031 - 0.07
all-trans retinaldehyde
0.0008 - 7.13
benzaldehyde
0.008 - 0.021
Butyraldehyde
0.0026 - 0.0101
cinnamaldehyde
0.0148 - 1.647
crotonaldehyde
0.0154 - 0.0259
ethyl vanillin
0.011 - 0.049
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
0.0029 - 0.05
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
0.087 - 0.482
N1-methyl-nicotineamide
0.0255 - 0.1285
N1-methylnicotinamide
0.0025 - 0.385
phenanthridine
0.0318 - 0.2797
phenylacetaldehyde
0.0111 - 0.0985
phenylpropionaldehyde
0.0011 - 1.264
Phthalazine
0.2264 - 1.634
propionaldehyde
0.0126 - 0.07
retinalaldehyde
0.0075 - 0.0558
retinaldehyde
0.0035 - 3.886
Salicylaldehyde
additional information
additional information
further kinetic parameters of phthalazine-DCPIP reaction in the absence or presence of the inhibitors benzamidine, menadione, norharmane, and raloxifene available in the publication
-
0.0004
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0004
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0211
Salicylaldehyde
pH 8, 37°C
0.0211
Salicylaldehyde
pH 8, 37°C
0.0023
Vanillin
pH 8, 37°C
0.0023
Vanillin
pH 8, 37°C
0.0021
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.0263
2,4-dihydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.2525
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.06
2-hydroxypyrimidine
-
25°C, pH 7.4
0.097
2-hydroxypyrimidine
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.17
2-hydroxypyrimidine
-
25°C, pH 7.4
0.173
2-hydroxypyrimidine
-
apparent Km-value of native mAOX3, pH 7.4, 25°C
8.3
2-hydroxypyrimidine
-
male enzyme
14.7
2-hydroxypyrimidine
-
female enzyme
0.0066
2-Methoxybenzaldehyde
pH 8, 37°C
0.0194
2-Methoxybenzaldehyde
pH 8, 37°C
0.0084
3-Methoxybenzaldehyde
pH 8, 37°C
0.0201
3-Methoxybenzaldehyde
pH 8, 37°C
0.0005
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0005
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0008
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0008
4-(dimethylamino)cinnamaldehyde
wild-type, pH 8.0, 37°C
0.0033
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0033
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.0019
4-hydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.0028
4-hydroxybenzaldehyde
pH 8, 37°C
0.0346
4-hydroxybenzaldehyde
pH 8, 37°C
0.0118
4-methoxybenzaldehyde
pH 8, 37°C
0.0234
4-methoxybenzaldehyde
pH 8, 37°C
0.0013
4-nitrobenzaldehyde
wild-type, pH 8.0, 37°C
0.0032
4-nitrobenzaldehyde
pH 8, 37°C
0.0176
4-nitrobenzaldehyde
pH 8, 37°C
0.5199
acetaldehyde
wild-type, 30°C, pH 7.4
0.8
acetaldehyde
-
25°C, pH 7.4
0.82
acetaldehyde
-
25°C, pH 7.4
4.42
acetaldehyde
pH 8, 37°C
4.596
acetaldehyde
wild-type, pH 8.0, 37°C
18.094
acetaldehyde
pH 8, 37°C
52.9
acetaldehyde
mutant V806E, 30°C, pH 7.4
0.031
all-trans retinaldehyde
-
0.07
all-trans retinaldehyde
-
0.133
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.426
allopurinol
mutant P1015G, pH 8.0,37°C
0.527
allopurinol
mutant P1015A, pH 8.0,37°C
1.595
allopurinol
wild-type, pH 8.0,37°C
2.93
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
3.86
allopurinol
mutant F1014V, pH 8.0,37°C
0.0008
benzaldehyde
pH 8, 37°C
0.0008
benzaldehyde
mutant M1088V, pH 8.0, 37°C
0.0011
benzaldehyde
mutant I1018S, pH 8.0, 37°C
0.0021
benzaldehyde
mutant I1018K, pH 8.0, 37°C
0.0022
benzaldehyde
wild-type, pH 8.0, 37°C
0.0022
benzaldehyde
mutant P1015A, pH 8.0,37°C
0.0023
benzaldehyde
K889H mutant, pH 8.0, 37°C
0.0025
benzaldehyde
mAOX3 wild type, pH 8.0, 37°C
0.0025
benzaldehyde
wild-type, pH 8.0,37°C
0.0029
benzaldehyde
A807V mutant, pH 8.0, 37°C
0.0033
benzaldehyde
mutant P1015G, pH 8.0,37°C
0.004
benzaldehyde
-
25°C, pH 7.4
0.0046
benzaldehyde
A807V/Y885M double mutant, pH 8.0, 37°C
0.0051
benzaldehyde
mutant V1016I, pH 8.0, 37°C
0.0063
benzaldehyde
Y885M mutant, pH 8.0, 37°C
0.0064
benzaldehyde
mutant M1088T, pH 8.0, 37°C
0.012
benzaldehyde
-
25°C, pH 7.4
0.013
benzaldehyde
-
apparent Km-value of native mAOX3, pH 7.4, 25°C
0.0195
benzaldehyde
pH 8, 37°C
0.02
benzaldehyde
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.0215
benzaldehyde
mutant F1014V, pH 8.0,37°C
0.0227
benzaldehyde
mutant F1014I, pH 8.0,37°C
0.0287
benzaldehyde
mutant V1016L, pH 8.0, 37°C
0.039
benzaldehyde
-
female enzyme treated with testosterone propionate
0.04
benzaldehyde
-
male enzyme
0.0863
benzaldehyde
E1266Q mutant, pH 8.0, 37°C
0.0977
benzaldehyde
wild-type, 30°C, pH 7.4
0.115
benzaldehyde
-
female enzyme
0.6345
benzaldehyde
mutant V806E, 30°C, pH 7.4
1.092
benzaldehyde
mutant V1016F, pH 8.0, 37°C
2.21
benzaldehyde
mutant F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L, pH 8.0,37°C
7.13
benzaldehyde
mutant M884R, 30°C, pH 7.4
0.0085
Butanal
pH 8, 37°C
0.026
Butanal
-
apparent Km-value of recombinant mAOX3, pH 7.4, 25°C
0.029
Butanal
-
apparent Km-value of native mAOX3, pH 7.4, 25°C
0.0575
Butanal
wild-type, pH 8.0, 37°C
0.008
Butyraldehyde
-
25°C, pH 7.4
0.021
Butyraldehyde
-
25°C, pH 7.4
0.0026
cinnamaldehyde
pH 8, 37°C
0.0101
cinnamaldehyde
pH 8, 37°C
0.0148
crotonaldehyde
wild-type, pH 8.0, 37°C
0.3806
crotonaldehyde
pH 8, 37°C
1.647
crotonaldehyde
pH 8, 37°C
0.0154
ethyl vanillin
pH 8, 37°C
0.0259
ethyl vanillin
pH 8, 37°C
0.002
Heptanal
wild-type, pH 8.0, 37°C
0.0039
Heptanal
pH 8, 37°C
0.0455
Heptanal
pH 8, 37°C
0.0032
hexanal
wild-type, pH 8.0, 37°C
0.0041
hexanal
pH 8, 37°C
0.0392
hexanal
pH 8, 37°C
0.011
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
female enzyme treated with testosterone propionate
0.012
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
male enzyme
0.049
N-[(2-dimethylamino)ethyl] acridine-4-carboxamide
-
female enzyme
0.0029
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, strain c129/C57
0.0055
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, nude mouse tumor bearing
0.0074
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, nude mouse
0.027
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, female swiss CD
0.03
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, male swiss CD
0.05
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
-
37°C, pH 7.8, strain CB57BI/6J
0.087
N1-methyl-nicotineamide
mutant P1015A, pH 8.0,37°C
0.089
N1-methyl-nicotineamide
mutant P1015G, pH 8.0,37°C
0.128
N1-methyl-nicotineamide
wild-type, pH 8.0,37°C
0.482
N1-methyl-nicotineamide
mutant F1014V, pH 8.0,37°C
0.0255
N1-methylnicotinamide
K889H mutant, pH 8.0, 37°C
0.0279
N1-methylnicotinamide
pH 8, 37°C
0.0359
N1-methylnicotinamide
A807V/Y885M double mutant, pH 8.0, 37°C
0.0827
N1-methylnicotinamide
Y885M mutant, pH 8.0, 37°C
0.1234
N1-methylnicotinamide
A807V mutant, pH 8.0, 37°C
0.1285
N1-methylnicotinamide
mAOX3 wild type, pH 8.0, 37°C
0.0032
octanal
pH 8, 37°C
0.0071
octanal
wild-type, pH 8.0, 37°C
0.0645
octanal
pH 8, 37°C
0.0134
pentanal
mutant I1018K, pH 8.0, 37°C
0.0134
pentanal
mutant I1018S, pH 8.0, 37°C
0.0284
pentanal
mutant M1088V, pH 8.0, 37°C
0.0293
pentanal
mutant V1016I, pH 8.0, 37°C
0.0483
pentanal
wild-type, pH 8.0, 37°C
0.057
pentanal
mutant M1088T, pH 8.0, 37°C
0.0692
pentanal
pH 8, 37°C
0.1356
pentanal
pH 8, 37°C
5.566
pentanal
mutant V1016F, pH 8.0, 37°C
0.0025
phenanthridine
pH 8, 37°C
0.0108
phenanthridine
pH 8, 37°C
0.0118
phenanthridine
A807V/Y885M double mutant, pH 8.0, 37°C
0.0161
phenanthridine
K889H mutant, pH 8.0, 37°C
0.032
phenanthridine
wild-type, pH 8.0,37°C
0.0323
phenanthridine
mAOX3 wild type, pH 8.0, 37°C
0.0334
phenanthridine
Y885M mutant, pH 8.0, 37°C
0.047
phenanthridine
mutant P1015G, pH 8.0,37°C
0.073
phenanthridine
mutant F1014I, pH 8.0,37°C
0.099
phenanthridine
mutant P1015A, pH 8.0,37°C
0.1495
phenanthridine
A807V mutant, pH 8.0, 37°C
0.385
phenanthridine
mutant F1014V, pH 8.0,37°C
0.0318
phenylacetaldehyde
wild-type, pH 8.0, 37°C
0.1134
phenylacetaldehyde
pH 8, 37°C
0.2797
phenylacetaldehyde
pH 8, 37°C
0.0111
phenylpropionaldehyde
wild-type, pH 8.0, 37°C
0.0611
phenylpropionaldehyde
pH 8, 37°C
0.0985
phenylpropionaldehyde
pH 8, 37°C
0.0011
Phthalazine
K889H mutant, pH 8.0, 37°C
0.0014
Phthalazine
mAOX3 wild type, pH 8.0, 37°C
0.0014
Phthalazine
wild-type, pH 8.0,37°C
0.0021
Phthalazine
pH 8, 37°C
0.0026
Phthalazine
mutant P1015A, pH 8.0,37°C
0.0027
Phthalazine
A807V mutant, pH 8.0, 37°C
0.0029
Phthalazine
A807V/Y885M double mutant, pH 8.0, 37°C
0.0032
Phthalazine
Y885M mutant, pH 8.0, 37°C
0.0033
Phthalazine
mutant M1088V, pH 8.0, 37°C
0.0077
Phthalazine
mutant I1018K, pH 8.0, 37°C
0.0083
Phthalazine
wild-type, pH 8.0, 37°C
0.0086
Phthalazine
pH 8, 37°C
0.009
Phthalazine
mutant F1014I, pH 8.0,37°C
0.0094
Phthalazine
mutant M1088T, pH 8.0, 37°C
0.0103
Phthalazine
mutant P1015G, pH 8.0,37°C
0.0106
Phthalazine
mutant V1016I, pH 8.0, 37°C
0.0114
Phthalazine
wild-type, 30°C, pH 7.4
0.0125
Phthalazine
mutant F1014V, pH 8.0,37°C
0.013
Phthalazine
mutant V1016L, pH 8.0, 37°C
0.0285
Phthalazine
mutant V806E, 30°C, pH 7.4
0.059
Phthalazine
mutant I1018S, pH 8.0, 37°C
0.733
Phthalazine
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
1.264
Phthalazine
mutant V1016F, pH 8.0, 37°C
0.2264
propionaldehyde
wild-type, pH 8.0, 37°C
0.289
propionaldehyde
pH 8, 37°C
1.634
propionaldehyde
pH 8, 37°C
3.181
purine
pH 8, 37°C
12.34
purine
wild-type, pH 8.0, 37°C
0.0038
retinal
-
-
0.0126
retinalaldehyde
pH 8, 37°C
0.0165
retinalaldehyde
pH 8, 37°C
0.03
retinalaldehyde
-
25°C, pH 7.4
0.0321
retinalaldehyde
pH 8, 37°C
0.07
retinalaldehyde
-
25°C, pH 7.4
0.0075
retinaldehyde
mutant M884R, 30°C, pH 7.4
0.0222
retinaldehyde
mutant V806E, 30°C, pH 7.4
0.0558
retinaldehyde
wild-type, 30°C, pH 7.4
0.0035
Salicylaldehyde
pH 8, 37°C
0.0035
Salicylaldehyde
pH 8, 37°C
0.0081
Salicylaldehyde
mutant I1018K, pH 8.0, 37°C
0.0092
Salicylaldehyde
mutant I1018S, pH 8.0, 37°C
0.0132
Salicylaldehyde
pH 8, 37°C
0.0132
Salicylaldehyde
wild-type, pH 8.0, 37°C
0.0136
Salicylaldehyde
mutant M1088V, pH 8.0, 37°C
0.0238
Salicylaldehyde
mutant M1088T, pH 8.0, 37°C
0.0447
Salicylaldehyde
mutant V1016I, pH 8.0, 37°C
0.0559
Salicylaldehyde
mutant V1016L, pH 8.0, 37°C
0.0896
Salicylaldehyde
pH 8, 37°C
0.0896
Salicylaldehyde
pH 8, 37°C
3.886
Salicylaldehyde
mutant V1016F, pH 8.0, 37°C
0.0046
Vanillin
pH 8, 37°C
0.0046
Vanillin
pH 8, 37°C
0.0054
Vanillin
pH 8, 37°C
0.0054
Vanillin
wild-type, pH 8.0, 37°C
0.104
Vanillin
pH 8, 37°C
0.104
Vanillin
pH 8, 37°C
0.027
zebularine
-
female, pH 7.5, 37°C
0.102
zebularine
-
male, pH 7.5, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.86
2,4-dihydroxybenzaldehyde
pH 8, 37°C
0.64
2-Methoxybenzaldehyde
pH 8, 37°C
1.9
3-Methoxybenzaldehyde
pH 8, 37°C
0.75
4-(dimethylamino)cinnamaldehyde
1.94
4-hydroxybenzaldehyde
pH 8, 37°C
2.14
4-methoxybenzaldehyde
pH 8, 37°C
2.12
4-nitrobenzaldehyde
pH 8, 37°C
1.48
acetaldehyde
pH 8, 37°C
4.7
benzaldehyde
pH 8, 37°C
1.67
cinnamaldehyde
pH 8, 37°C
2.11
crotonaldehyde
pH 8, 37°C
1.48
ethyl vanillin
pH 8, 37°C
0.82
N1-methylnicotinamide
pH 8, 37°C
1.96
phenanthridine
pH 8, 37°C
1.99
phenylacetaldehyde
pH 8, 37°C
1.35
phenylpropionaldehyde
pH 8, 37°C
4.12
Phthalazine
pH 8, 37°C
0.66
propionaldehyde
pH 8, 37°C
0.47
retinalaldehyde
pH 8, 37°C
3.69 - 3.7
Salicylaldehyde
0.96 - 3.39
2,4-dihydroxybenzaldehyde
6.88 - 21.32
2-hydroxypyrimidine
6.89
2-Methoxybenzaldehyde
pH 8, 37°C
4.3 - 6.2
3-Methoxybenzaldehyde
0.51 - 1.94
4-(dimethylamino)cinnamaldehyde
0.53 - 4.31
4-hydroxybenzaldehyde
3.75 - 7.37
4-methoxybenzaldehyde
0.52 - 2.41
4-nitrobenzaldehyde
2.73 - 2.95
cinnamaldehyde
1.22 - 8.32
crotonaldehyde
1.24 - 6.35
ethyl vanillin
0.38 - 1.92
N1-methyl-nicotineamide
0.052 - 0.45
N1-methylnicotinamide
0.18 - 9.68
phenanthridine
0.47 - 4.66
phenylacetaldehyde
0.53 - 6.32
phenylpropionaldehyde
1.41 - 5.06
propionaldehyde
0.18 - 2.05
retinalaldehyde
0.022 - 0.83
retinaldehyde
0.39 - 11.25
Salicylaldehyde
additional information
additional information
further kinetic parameters of phthalazine-DCPIP reaction in the absence or presence of the inhibitors benzamidine, menadione, norharmane, and raloxifene available in the publication
-
0.75
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.75
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
3.69
Salicylaldehyde
pH 8, 37°C
3.7
Salicylaldehyde
pH 8, 37°C
1.34
Vanillin
pH 8, 37°C
0.96
2,4-dihydroxybenzaldehyde
pH 8, 37°C
1.65
2,4-dihydroxybenzaldehyde
pH 8, 37°C
3.39
2,4-dihydroxybenzaldehyde
wild-type, pH 8.0, 37°C
6.88
2-hydroxypyrimidine
-
apparent Kcat-value of recombinant mAOX3, pH 7.4, 25°C
21.32
2-hydroxypyrimidine
-
apparent Kcat-value of native mAOX3, pH 7.4, 25°C
4.3
3-Methoxybenzaldehyde
pH 8, 37°C
6.2
3-Methoxybenzaldehyde
pH 8, 37°C
0.51
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.51
4-(dimethylamino)cinnamaldehyde
wild-type, pH 8.0, 37°C
1.47
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.47
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.94
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
1.94
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
0.53
4-hydroxybenzaldehyde
wild-type, pH 8.0, 37°C
0.91
4-hydroxybenzaldehyde
pH 8, 37°C
4.31
4-hydroxybenzaldehyde
pH 8, 37°C
3.75
4-methoxybenzaldehyde
pH 8, 37°C
7.37
4-methoxybenzaldehyde
pH 8, 37°C
0.52
4-nitrobenzaldehyde
wild-type, pH 8.0, 37°C
1.57
4-nitrobenzaldehyde
pH 8, 37°C
2.41
4-nitrobenzaldehyde
pH 8, 37°C
2.7
acetaldehyde
mutant V806E, 30°C, pH 7.4
3.31
acetaldehyde
wild-type, pH 8.0, 37°C
5.81
acetaldehyde
pH 8, 37°C
7.04
acetaldehyde
pH 8, 37°C
8.66
acetaldehyde
wild-type, 30°C, pH 7.4
0.27
allopurinol
mutant F1014V, pH 8.0,37°C
0.62
allopurinol
mutant P1015G, pH 8.0,37°C
0.77
allopurinol
mutant P1015A, pH 8.0,37°C
1.22
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
1.22
allopurinol
wild-type, pH 8.0,37°C
1.58
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.17
benzaldehyde
E1266Q mutant, pH 8.0, 37°C
0.31
benzaldehyde
mutant F1014I, pH 8.0,37°C
0.32
benzaldehyde
K889H mutant, pH 8.0, 37°C
0.39
benzaldehyde
mutant V1016I, pH 8.0, 37°C
0.47
benzaldehyde
mutant V1016L, pH 8.0, 37°C
0.59
benzaldehyde
mutant M1088V, pH 8.0, 37°C
0.66
benzaldehyde
mutant V1016F, pH 8.0, 37°C
0.683
benzaldehyde
A807V mutant, pH 8.0, 37°C
0.698
benzaldehyde
mAOX3 wild type, pH 8.0, 37°C
0.727
benzaldehyde
A807V/Y885M double mutant, pH 8.0, 37°C
0.733
benzaldehyde
-
apparent Kcat-value of recombinant mAOX3, pH 7.4, 25°C
0.957
benzaldehyde
Y885M mutant, pH 8.0, 37°C
1.13
benzaldehyde
wild-type, pH 8.0,37°C
1.14
benzaldehyde
mutant I1018K, pH 8.0, 37°C
1.25
benzaldehyde
mutant I1018S, pH 8.0, 37°C
1.27
benzaldehyde
mutant M884R, 30°C, pH 7.4
1.27
benzaldehyde
mutant P1015A, pH 8.0,37°C
1.52
benzaldehyde
wild-type, pH 8.0, 37°C
1.55
benzaldehyde
mutant P1015G, pH 8.0,37°C
2.13
benzaldehyde
mutant F1014V, pH 8.0,37°C
2.167
benzaldehyde
-
apparent Kcat-value of native mAOX3, pH 7.4, 25°C
2.51
benzaldehyde
pH 8, 37°C
2.52
benzaldehyde
mutant V806E, 30°C, pH 7.4
3.51
benzaldehyde
pH 8, 37°C
3.9
benzaldehyde
mutant F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L, pH 8.0,37°C
5.29
benzaldehyde
wild-type, 30°C, pH 7.4
5.32
benzaldehyde
mutant M1088T, pH 8.0, 37°C
1.84
Butanal
wild-type, pH 8.0, 37°C
2.333
Butanal
-
apparent Kcat-value of recombinant mAOX3, pH 7.4, 25°C
6.4
Butanal
-
apparent Kcat-value of native mAOX3, pH 7.4, 25°C
2.73
cinnamaldehyde
pH 8, 37°C
2.95
cinnamaldehyde
pH 8, 37°C
1.22
crotonaldehyde
wild-type, pH 8.0, 37°C
7.76
crotonaldehyde
pH 8, 37°C
8.32
crotonaldehyde
pH 8, 37°C
1.24
ethyl vanillin
pH 8, 37°C
6.35
ethyl vanillin
pH 8, 37°C
0.54
Heptanal
wild-type, pH 8.0, 37°C
0.54
hexanal
wild-type, pH 8.0, 37°C
0.38
N1-methyl-nicotineamide
mutant F1014V, pH 8.0,37°C
0.4
N1-methyl-nicotineamide
wild-type, pH 8.0,37°C
1.08
N1-methyl-nicotineamide
mutant P1015A, pH 8.0,37°C
1.92
N1-methyl-nicotineamide
mutant P1015G, pH 8.0,37°C
0.052
N1-methylnicotinamide
K889H mutant, pH 8.0, 37°C
0.187
N1-methylnicotinamide
A807V mutant, pH 8.0, 37°C
0.245
N1-methylnicotinamide
mAOX3 wild type, pH 8.0, 37°C
0.33
N1-methylnicotinamide
pH 8, 37°C
0.39
N1-methylnicotinamide
Y885M mutant, pH 8.0, 37°C
0.45
N1-methylnicotinamide
A807V/Y885M double mutant, pH 8.0, 37°C
0.75
octanal
pH 8, 37°C
0.8
octanal
wild-type, pH 8.0, 37°C
0.45
pentanal
mutant V1016I, pH 8.0, 37°C
0.92
pentanal
mutant M1088V, pH 8.0, 37°C
1.11
pentanal
mutant V1016F, pH 8.0, 37°C
1.28
pentanal
mutant I1018K, pH 8.0, 37°C
2.65
pentanal
mutant I1018S, pH 8.0, 37°C
2.79
pentanal
wild-type, pH 8.0, 37°C
7.98
pentanal
mutant M1088T, pH 8.0, 37°C
0.18
phenanthridine
mutant F1014I, pH 8.0,37°C
0.862
phenanthridine
mAOX3 wild type, pH 8.0, 37°C
1.33
phenanthridine
K889H mutant, pH 8.0, 37°C
1.42
phenanthridine
mutant F1014V, pH 8.0,37°C
1.42
phenanthridine
wild-type, pH 8.0,37°C
2.01
phenanthridine
pH 8, 37°C
2.35
phenanthridine
pH 8, 37°C
3.63
phenanthridine
A807V/Y885M double mutant, pH 8.0, 37°C
4.45
phenanthridine
Y885M mutant, pH 8.0, 37°C
5.25
phenanthridine
A807V mutant, pH 8.0, 37°C
8.83
phenanthridine
mutant P1015G, pH 8.0,37°C
9.68
phenanthridine
mutant P1015A, pH 8.0,37°C
0.47
phenylacetaldehyde
wild-type, pH 8.0, 37°C
2.28
phenylacetaldehyde
pH 8, 37°C
4.66
phenylacetaldehyde
pH 8, 37°C
0.53
phenylpropionaldehyde
wild-type, pH 8.0, 37°C
1.49
phenylpropionaldehyde
pH 8, 37°C
6.32
phenylpropionaldehyde
pH 8, 37°C
0.19
Phthalazine
wild-type, 30°C, pH 7.4
0.197
Phthalazine
K889H mutant, pH 8.0, 37°C
0.22
Phthalazine
mutant V1016L, pH 8.0, 37°C
0.28
Phthalazine
mutant V1016I, pH 8.0, 37°C
0.67
Phthalazine
mutant V1016F, pH 8.0, 37°C
0.685
Phthalazine
A807V mutant, pH 8.0, 37°C
0.685
Phthalazine
mAOX3 wild type, pH 8.0, 37°C
0.69
Phthalazine
A807V/Y885M double mutant, pH 8.0, 37°C
0.815
Phthalazine
Y885M mutant, pH 8.0, 37°C
0.97
Phthalazine
mutant F1014I, pH 8.0,37°C
1.04
Phthalazine
mutant M1088V, pH 8.0, 37°C
1.1
Phthalazine
wild-type, pH 8.0,37°C
1.62
Phthalazine
pH 8, 37°C
1.72
Phthalazine
mutant V806E, 30°C, pH 7.4
1.9
Phthalazine
mutant I1018K, pH 8.0, 37°C
2.92
Phthalazine
pH 8, 37°C
2.98
Phthalazine
mutant P1015A, pH 8.0,37°C
4.63
Phthalazine
mutant F1014V, pH 8.0,37°C
5.3
Phthalazine
mutant I1018S, pH 8.0, 37°C
5.52
Phthalazine
wild-type, pH 8.0, 37°C
5.78
Phthalazine
mutant P1015G, pH 8.0,37°C
8.73
Phthalazine
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
10.3
Phthalazine
mutant M1088T, pH 8.0, 37°C
1.41
propionaldehyde
wild-type, pH 8.0, 37°C
2.39
propionaldehyde
pH 8, 37°C
5.06
propionaldehyde
pH 8, 37°C
0.3
purine
wild-type, pH 8.0, 37°C
0.18
retinalaldehyde
pH 8, 37°C
2.05
retinalaldehyde
pH 8, 37°C
0.022
retinaldehyde
mutant M884R, 30°C, pH 7.4
0.23
retinaldehyde
mutant V806E, 30°C, pH 7.4
0.83
retinaldehyde
wild-type, 30°C, pH 7.4
0.39
Salicylaldehyde
mutant V1016F, pH 8.0, 37°C
0.58
Salicylaldehyde
mutant V1016I, pH 8.0, 37°C
0.93
Salicylaldehyde
mutant V1016L, pH 8.0, 37°C
1.14
Salicylaldehyde
mutant M1088V, pH 8.0, 37°C
1.89
Salicylaldehyde
mutant I1018K, pH 8.0, 37°C
2.29
Salicylaldehyde
pH 8, 37°C
2.29
Salicylaldehyde
pH 8, 37°C
3.42
Salicylaldehyde
pH 8, 37°C
3.42
Salicylaldehyde
wild-type, pH 8.0, 37°C
3.55
Salicylaldehyde
pH 8, 37°C
3.55
Salicylaldehyde
pH 8, 37°C
5.12
Salicylaldehyde
mutant I1018S, pH 8.0, 37°C
11.25
Salicylaldehyde
mutant M1088T, pH 8.0, 37°C
0.26
Vanillin
pH 8, 37°C
0.26
Vanillin
wild-type, pH 8.0, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6.7
2,4-dihydroxybenzaldehyde
pH 8, 37°C
1043
2-Methoxybenzaldehyde
pH 8, 37°C
512
3-Methoxybenzaldehyde
pH 8, 37°C
568 - 2088.3
4-(dimethylamino)cinnamaldehyde
138
4-hydroxybenzaldehyde
pH 8, 37°C
318
4-methoxybenzaldehyde
pH 8, 37°C
137
4-nitrobenzaldehyde
pH 8, 37°C
0.3
acetaldehyde
pH 8, 37°C
180
benzaldehyde
pH 8, 37°C
270
cinnamaldehyde
pH 8, 37°C
1.7
crotonaldehyde
pH 8, 37°C
245
ethyl vanillin
pH 8, 37°C
87.7
N1-methylnicotinamide
pH 8, 37°C
805
phenanthridine
pH 8, 37°C
42
phenylacetaldehyde
pH 8, 37°C
65
phenylpropionaldehyde
pH 8, 37°C
188
Phthalazine
pH 8, 37°C
3.2
propionaldehyde
pH 8, 37°C
18.3
retinalaldehyde
pH 8, 37°C
6.7 - 455
2,4-dihydroxybenzaldehyde
355 - 1043
2-Methoxybenzaldehyde
308 - 512
3-Methoxybenzaldehyde
568 - 3278.3
4-(dimethylamino)cinnamaldehyde
138 - 325
4-hydroxybenzaldehyde
315 - 318
4-methoxybenzaldehyde
137 - 490
4-nitrobenzaldehyde
0.00008 - 0.0119
allopurinol
0.0018 - 3140
benzaldehyde
270 - 1137
cinnamaldehyde
1.7 - 83.3
crotonaldehyde
0.0008 - 0.0216
N1-methyl-nicotineamide
1.52 - 12.5
N1-methylnicotinamide
0.0027 - 805
phenanthridine
8.3 - 42
phenylacetaldehyde
25 - 65
phenylpropionaldehyde
0.0119 - 1388
Phthalazine
3.2 - 8.3
propionaldehyde
13.3 - 123.3
retinalaldehyde
0.17 - 1007
Salicylaldehyde
568
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
2088.3
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
25
Salicylaldehyde
pH 8, 37°C
175
Salicylaldehyde
pH 8, 37°C
71.7
Vanillin
pH 8, 37°C
701.7
Vanillin
pH 8, 37°C
6.7
2,4-dihydroxybenzaldehyde
pH 8, 37°C
128
2,4-dihydroxybenzaldehyde
wild-type, pH 8.0, 37°C
455
2,4-dihydroxybenzaldehyde
pH 8, 37°C
355
2-Methoxybenzaldehyde
pH 8, 37°C
1043
2-Methoxybenzaldehyde
pH 8, 37°C
308
3-Methoxybenzaldehyde
pH 8, 37°C
512
3-Methoxybenzaldehyde
pH 8, 37°C
568
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
568.3
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
605
4-(dimethylamino)cinnamaldehyde
wild-type, pH 8.0, 37°C
605
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
3278
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
3278.3
4-(dimethylamino)cinnamaldehyde
pH 8, 37°C
138
4-hydroxybenzaldehyde
pH 8, 37°C
277
4-hydroxybenzaldehyde
wild-type, pH 8.0, 37°C
325
4-hydroxybenzaldehyde
pH 8, 37°C
315
4-methoxybenzaldehyde
pH 8, 37°C
318
4-methoxybenzaldehyde
pH 8, 37°C
137
4-nitrobenzaldehyde
pH 8, 37°C
397
4-nitrobenzaldehyde
wild-type, pH 8.0, 37°C
490
4-nitrobenzaldehyde
pH 8, 37°C
0.3
acetaldehyde
pH 8, 37°C
0.67
acetaldehyde
wild-type, pH 8.0, 37°C
1.3
acetaldehyde
pH 8, 37°C
0.00008
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.0001
allopurinol
mutant F1014V, pH 8.0,37°C
0.0007
allopurinol
wild-type, pH 8.0,37°C
0.0015
allopurinol
mutant P1015A, pH 8.0,37°C
0.0015
allopurinol
mutant P1015G, pH 8.0,37°C
0.0119
allopurinol
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.0018
benzaldehyde
mutant F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L, pH 8.0,37°C
0.013
benzaldehyde
mutant F1014I, pH 8.0,37°C
0.098
benzaldehyde
mutant F1014V, pH 8.0,37°C
0.45
benzaldehyde
wild-type, pH 8.0,37°C
0.47
benzaldehyde
mutant P1015G, pH 8.0,37°C
0.58
benzaldehyde
mutant P1015A, pH 8.0,37°C
0.67
benzaldehyde
mutant V1016F, pH 8.0, 37°C
1.97
benzaldehyde
E1266Q mutant, pH 8.0, 37°C
76.7
benzaldehyde
mutant V1016I, pH 8.0, 37°C
88.3
benzaldehyde
mutant V1016L, pH 8.0, 37°C
136.7
benzaldehyde
K889H mutant, pH 8.0, 37°C
151.8
benzaldehyde
Y885M mutant, pH 8.0, 37°C
158
benzaldehyde
A807V/Y885M double mutant, pH 8.0, 37°C
180
benzaldehyde
pH 8, 37°C
235.7
benzaldehyde
A807V mutant, pH 8.0, 37°C
279.3
benzaldehyde
mAOX3 wild type, pH 8.0, 37°C
545
benzaldehyde
mutant I1018K, pH 8.0, 37°C
693
benzaldehyde
wild-type, pH 8.0, 37°C
735
benzaldehyde
mutant M1088V, pH 8.0, 37°C
831.7
benzaldehyde
mutant M1088T, pH 8.0, 37°C
1136.7
benzaldehyde
mutant I1018S, pH 8.0, 37°C
3140
benzaldehyde
pH 8, 37°C
3.3
Butanal
pH 8, 37°C
31.7
Butanal
wild-type, pH 8.0, 37°C
270
cinnamaldehyde
pH 8, 37°C
1137
cinnamaldehyde
pH 8, 37°C
1.7
crotonaldehyde
pH 8, 37°C
20
crotonaldehyde
pH 8, 37°C
83.3
crotonaldehyde
wild-type, pH 8.0, 37°C
245
ethyl vanillin
pH 8, 37°C
257
ethyl vanillin
pH 8, 37°C
98
Heptanal
pH 8, 37°C
270
Heptanal
wild-type, pH 8.0, 37°C
117
hexanal
pH 8, 37°C
166.7
hexanal
wild-type, pH 8.0, 37°C
0.0008
N1-methyl-nicotineamide
mutant F1014V, pH 8.0,37°C
0.0031
N1-methyl-nicotineamide
wild-type, pH 8.0,37°C
0.0124
N1-methyl-nicotineamide
mutant P1015A, pH 8.0,37°C
0.0216
N1-methyl-nicotineamide
mutant P1015G, pH 8.0,37°C
1.52
N1-methylnicotinamide
A807V mutant, pH 8.0, 37°C
1.92
N1-methylnicotinamide
mAOX3 wild type, pH 8.0, 37°C
2
N1-methylnicotinamide
K889H mutant, pH 8.0, 37°C
4.72
N1-methylnicotinamide
Y885M mutant, pH 8.0, 37°C
11.7
N1-methylnicotinamide
pH 8, 37°C
12.5
N1-methylnicotinamide
A807V/Y885M double mutant, pH 8.0, 37°C
70
octanal
pH 8, 37°C
111.7
octanal
wild-type, pH 8.0, 37°C
0.17
pentanal
mutant V1016F, pH 8.0, 37°C
15
pentanal
mutant V1016I, pH 8.0, 37°C
31.7
pentanal
mutant M1088V, pH 8.0, 37°C
58.3
pentanal
wild-type, pH 8.0, 37°C
95
pentanal
mutant I1018K, pH 8.0, 37°C
140
pentanal
mutant M1088T, pH 8.0, 37°C
196.7
pentanal
mutant I1018S, pH 8.0, 37°C
0.0027
phenanthridine
mutant F1014I, pH 8.0,37°C
0.0037
phenanthridine
mutant F1014V, pH 8.0,37°C
0.044
phenanthridine
wild-type, pH 8.0,37°C
0.098
phenanthridine
mutant P1015A, pH 8.0,37°C
0.189
phenanthridine
mutant P1015G, pH 8.0,37°C
26.7
phenanthridine
mAOX3 wild type, pH 8.0, 37°C
35.2
phenanthridine
A807V mutant, pH 8.0, 37°C
82.8
phenanthridine
K889H mutant, pH 8.0, 37°C
133.2
phenanthridine
Y885M mutant, pH 8.0, 37°C
218
phenanthridine
pH 8, 37°C
307.8
phenanthridine
A807V/Y885M double mutant, pH 8.0, 37°C
805
phenanthridine
pH 8, 37°C
8.3
phenylacetaldehyde
pH 8, 37°C
15
phenylacetaldehyde
wild-type, pH 8.0, 37°C
42
phenylacetaldehyde
pH 8, 37°C
25
phenylpropionaldehyde
pH 8, 37°C
46.7
phenylpropionaldehyde
wild-type, pH 8.0, 37°C
65
phenylpropionaldehyde
pH 8, 37°C
0.0119
Phthalazine
mutant F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L, pH 8.0,37°C
0.11
Phthalazine
mutant F1014I, pH 8.0,37°C
0.37
Phthalazine
mutant F1014V, pH 8.0,37°C
0.5
Phthalazine
mutant V1016F, pH 8.0, 37°C
0.56
Phthalazine
mutant P1015G, pH 8.0,37°C
0.79
Phthalazine
wild-type, pH 8.0,37°C
1.148
Phthalazine
mutant P1015A, pH 8.0,37°C
8.3
Phthalazine
mutant V1016L, pH 8.0, 37°C
26.7
Phthalazine
mutant V1016I, pH 8.0, 37°C
175.5
Phthalazine
K889H mutant, pH 8.0, 37°C
188
Phthalazine
pH 8, 37°C
238
Phthalazine
A807V/Y885M double mutant, pH 8.0, 37°C
248.3
Phthalazine
mutant I1018K, pH 8.0, 37°C
253.7
Phthalazine
A807V mutant, pH 8.0, 37°C
254.7
Phthalazine
Y885M mutant, pH 8.0, 37°C
315
Phthalazine
mutant M1088V, pH 8.0, 37°C
489.3
Phthalazine
mAOX3 wild type, pH 8.0, 37°C
665
Phthalazine
wild-type, pH 8.0, 37°C
896.7
Phthalazine
mutant I1018S, pH 8.0, 37°C
1096.7
Phthalazine
mutant M1088T, pH 8.0, 37°C
1388
Phthalazine
pH 8, 37°C
3.2
propionaldehyde
pH 8, 37°C
6.2
propionaldehyde
wild-type, pH 8.0, 37°C
8.3
propionaldehyde
pH 8, 37°C
0.02
purine
wild-type, pH 8.0, 37°C
13.3
retinalaldehyde
pH 8, 37°C
123.3
retinalaldehyde
pH 8, 37°C
0.17
Salicylaldehyde
mutant V1016F, pH 8.0, 37°C
13.3
Salicylaldehyde
mutant V1016I, pH 8.0, 37°C
25
Salicylaldehyde
pH 8, 37°C
25
Salicylaldehyde
pH 8, 37°C
53.3
Salicylaldehyde
mutant V1016L, pH 8.0, 37°C
83.3
Salicylaldehyde
mutant M1088V, pH 8.0, 37°C
235
Salicylaldehyde
mutant I1018K, pH 8.0, 37°C
260
Salicylaldehyde
wild-type, pH 8.0, 37°C
260
Salicylaldehyde
pH 8, 37°C
473.3
Salicylaldehyde
mutant M1088T, pH 8.0, 37°C
556.7
Salicylaldehyde
mutant I1018S, pH 8.0, 37°C
1006.7
Salicylaldehyde
pH 8, 37°C
1007
Salicylaldehyde
pH 8, 37°C
48.3
Vanillin
pH 8, 37°C
50
Vanillin
wild-type, pH 8.0, 37°C
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A807V
does not affect the kinetic constants with smaller substrates like benzaldehyde or phthalazine, but affinity for bulkier substrates like phenanthridine decreases, whereas the catalytic efficiency is slightly raised
E1265Q
catalytically inactive, residue E1265 initiates the base-catalyzed mechanism of substrate oxidation
E1266Q
complete loss of activity with different N-heterocyclic compounds as substrates, 60% reduction of enzyme activity with benzaldehyde
F1014I
amino acid exchange in the active site
F1014L
amino acid exchange in the active site, 10fold increase in molybdenim content
F1014V
amino acid exchange in the active site
F776K/A807E/D878L/L881S/Y885R/K889H/P1015T/Y1019L
all residues in the first coordination sphere around the substrate are exchanged to their counterparts in bovine xanthine oxidoreductase. Mutant shows activity towards benzaldehyde, phthalazine and hypoxanthine
F776K/A807E/D878L/L881S/Y885R/P1015T/Y1019L
all residues in the first coordination sphere around the substrate except K889 are exchanged to their counterparts in bovine xanthine oxidoreductase, mutant is devoid of activity towards most substrates tested, while allopurinnol is oxidized at a low rate
I1018K
activities roughly similar to wild-type
I1018S
KM is decreased 1.5-3fold, while the kcat values overall mainly remain unaffected with all substrates
K889H
23fold decrease in the catalytic efficiency using benzaldehyde and phthalazine as substrates, but the Km-values remain the same
M1088T
the kcat values are significantly increased by about 3fold, mutant displays a lower molybdenum saturation of around 35%
M1088V
the kcat values are reduced to half of the activities of the wild-type enzyme, while the KM values mainly remain unchanged or are also 50% reduced
M884R
drastic decrease in the oxidation of aldehydes, with no increase in the oxidation of purine substrates
P1015A
amino acid exchange in the active site
P1015G
amino acid exchange in the active site
V1016F
about 80% decrease in the activity, with a lower molybdenum saturation of around 35%
V1016I
about 80% decrease in the activity
V1016L
about 80% decrease in the activity
V806E
drastic decrease in the oxidation of aldehydes, with no increase in the oxidation of purine substrates
V806E/M884R
catalytically inactive
Y885M
kinetic constants remain mainly the same with small hydrophobic substrates like benzaldehyde and phthalazine, bulkier substrates like phenanthridine or more charged substrates like N1-methylnicotinamide are converted with higher efficiency
additional information
-
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
additional information
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
additional information
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
additional information
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
additional information
AOH2 knock-out mice are viable and transmit the genetic deficit in a mendelian fashion
additional information
-
knock-down of isoform AOX1 by siRNA impairs adipogenesis and reduces adiponectin release
additional information
exchange of several residues in the active site to the ones found in other Aox homologues in mouse or to residues present in bovine xanthine oxidoreductase. Conversion of Aox3 to an xanthine oxidoreductase is achieved exchanging eight residues in the active site. Exchange of the iron-sulfur clusters FeSI, FeSII and both FeSI/FeSII by the corresponding domains of isoform Aox1 results in a decrease in catalytic activity with all substrates tested and both electron acceptor dichlorophenol indophenol and O2
additional information
-
exchange of several residues in the active site to the ones found in other Aox homologues in mouse or to residues present in bovine xanthine oxidoreductase. Conversion of Aox3 to an xanthine oxidoreductase is achieved exchanging eight residues in the active site. Exchange of the iron-sulfur clusters FeSI, FeSII and both FeSI/FeSII by the corresponding domains of isoform Aox1 results in a decrease in catalytic activity with all substrates tested and both electron acceptor dichlorophenol indophenol and O2
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