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Information on EC 1.2.1.5 - aldehyde dehydrogenase [NAD(P)+] and Organism(s) Mus musculus and UniProt Accession P47739

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This record set is specific for:
Mus musculus
UNIPROT: P47739 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
acetaldehyde dehydrogenase, aldh3, aldh1a, myo-inositol dehydrogenase, class 3 aldehyde dehydrogenase, aldh9, tumor-associated aldehyde dehydrogenase, aldh2a, bcaldh, osaldh7, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ALDH3A1
isozyme
ALDH
-
-
-
-
Aldh1a3
isozyme
Aldh3b1
isozyme
ALDHIII
-
-
-
-
BCP54
-
-
-
-
Corneal 15.8 kDa protein
-
-
-
-
Corneal protein 54
-
-
-
-
dehydrogenase, aldehyde (nicotinamide adenine dinucleotide (phosphate))
-
-
-
-
HTC-ALDH
-
-
-
-
Transparentin
-
-
-
-
Tumor-associated aldehyde dehydrogenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
aldehyde:NAD(P)+ oxidoreductase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9028-88-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
-
-
-
?
4-hydroxy-2-nonenal + NAD(P)+ + H2O
? + NAD(P)H + H+
show the reaction diagram
-
-
-
?
4-hydroxy-2-nonenal + NADP+ + H2O
4-hydroxy-2-nonenoic acid + NADPH + H+
show the reaction diagram
-
-
-
-
r
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NADP+
benzoate + NADPH
show the reaction diagram
-
-
-
-
?
hexanal + NAD+ + H2O
hexanoate + NADH + H+
show the reaction diagram
-
-
-
-
?
malondialdehyde + NAD(P)+ + H2O
? + NAD(P)H + H+
show the reaction diagram
-
-
-
?
malondialdehyde + NAD+
? + NADH
show the reaction diagram
-
-
-
-
?
trans-2-hexenal + NAD+
trans-2-hexenoate + NADH
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-hydroxy-2-nonenal + NAD(P)+ + H2O
? + NAD(P)H + H+
show the reaction diagram
-
-
-
?
malondialdehyde + NAD(P)+ + H2O
? + NAD(P)H + H+
show the reaction diagram
-
-
-
?
additional information
?
-
-
dual role for the corneal enzyme in providing the eye with protection against UV-B light: by oxidizing aldehydes generated through light-induced lipid peroxidation and by direct absorption of UV-B light by the enzyme
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
p-hydroxymercuribenzoate
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03
4-hydroxy-2-nonenal
-
-
15.63
acetaldehyde
-
-
0.11
benzaldehyde
-
-
0.08
hexanal
-
-
0.06
NAD+
-
-
1.4
NADP+
-
-
0.12
trans-2-hexenal
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
26.1
4-hydroxy-2-nonenal
-
-
33.5
acetaldehyde
-
-
20.9
benzaldehyde
-
-
34
hexanal
-
-
18.8
NAD+
-
reaction with benzyladehyde
33.1
NADP+
-
reaction with benzaldehyde
35.1
trans-2-hexenal
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.51
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
isozyme Aldh3a1 mRNA expression is highest in stomach
Manually annotated by BRENDA team
isoform ALDH3A1
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isoform ALDH3A1
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
isoforms ALDH3A1 plays a protective role against ultraviolet radiation-induced oxidative damage to ocular tissues, detoxifies reactive aldehydes and acts as antioxidant
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AL3A1_MOUSE
453
0
50481
Swiss-Prot
Mitochondrion (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110000
-
gel filtration
59000
-
2 * 59000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
-
2 * 59000, SDS-PAGE
homodimer
isoform ALDH3A1
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Downes, J.E.; Holmes, R.S.
Purification and properties of murine corneal aldehyde dehydrogenase
Biochem. Mol. Biol. Int.
30
525-535
1993
Mus musculus
Manually annotated by BRENDA team
Alnouti, Y.; Klaassen, C.D.
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice
Toxicol. Sci.
101
51-64
2008
Mus musculus (P47739), Mus musculus (Q80VQ0), Mus musculus (Q9JHW9)
Manually annotated by BRENDA team
Stagos, D.; Chen, Y.; Cantore, M.; Jester, J.V.; Vasiliou, V.
Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization
Brain Res. Bull.
81
211-218
2010
Mus musculus (Q9JHW9)
Manually annotated by BRENDA team