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Information on EC 1.2.1.36 - retinal dehydrogenase and Organism(s) Gallus gallus and UniProt Accession P27463

for references in articles please use BRENDA:EC1.2.1.36
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EC Tree
IUBMB Comments
A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.
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This record set is specific for:
Gallus gallus
UNIPROT: P27463
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
raldh2, raldh3, retinaldehyde dehydrogenase, retinal dehydrogenase, retinaldehyde dehydrogenase 2, retinaldehyde dehydrogenases, rdh13, retinal dehydrogenase 1, xctbp, retinaldehyde dehydrogenase-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
RalDH1
isoform
retinaldehyde dehydrogenase
-
retinaldehyde dehydrogenase 1
-
Aldh1a3
-
-
cytosolic retinal dehydrogenase
-
-
-
-
dehydrogenase, retinal
-
-
-
-
RALDH2
isoform
RALDH3
-
isoform
retinaldehyde dehydrogenase
retinaldehyde dehydrogenase 2
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
retinal:NAD+ oxidoreductase
A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.
CAS REGISTRY NUMBER
COMMENTARY hide
37250-99-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
show the reaction diagram
-
-
-
?
retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
show the reaction diagram
-
-
-
?
retinal + NAD+ + H2O
all-trans-retinoate + NADH + 2 H+
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dichloro-all-trans-retinone
irreversible inhibitor that effectively inhibits isoform RALDH1 in the nanomolar range. I.e. (3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one
-
dichloro-all-trans-retinone
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0807
retinal
isoform RALDH2, at pH 8.2 and 25°C
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0001944
dichloro-all-trans-retinone
isoform RALDH1, at pH 8.2 and 25°C
-
0.0000051 - 0.00000674
dichloro-all-trans-retinone
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004347
dichloro-all-trans-retinone
Gallus gallus
isoform RALDH1, at pH 8.2 and 25°C
-
0.000055 - 0.00016127
dichloro-all-trans-retinone
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in wild-type embryos, the distribution of Raldh-1 is limited to the dorsal third of the eye
Manually annotated by BRENDA team
in wild-type embryos, RALDH-3 is expressed within the developing eye vesicle in the ventral third of the retina
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AL1A1_CHICK
509
0
55809
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in HEK-293 cells
expressed in HEK-293 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Golz, S.; Muehleisen, T.; Schulte, D.; Mey, J.
Regulation of RALDH-1, RALDH-3 and CYP26A1 by transcription factors cVax/Vax2 and Tbx5 in the embryonic chick retina
Int. J. Dev. Neurosci.
26
435-445
2008
Gallus gallus (P27463), Gallus gallus (Q9DD46)
Manually annotated by BRENDA team
Harper, A.R.; Le, A.T.; Mather, T.; Burgett, A.; Berry, W.; Summers, J.A.
Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes
Bioorg. Med. Chem.
26
5766-5779
2018
Gallus gallus, Gallus gallus (O93344), Gallus gallus (P27463), Homo sapiens (O94788)
Manually annotated by BRENDA team