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Information on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+) and Organism(s) Mus musculus and UniProt Accession P47738

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EC Tree
IUBMB Comments
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
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This record set is specific for:
Mus musculus
UNIPROT: P47738
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
aldh2, aldh1, aldh1a1, aldehyde dehydrogenase 2, aldh1a3, aldh3a1, aldehyde dehydrogenase 1, aldh1a2, mitochondrial aldehyde dehydrogenase, aldehyde dehydrogenase-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aldehyde dehydrogenase 2
-
ALDH2
mitochondrial aldehyde dehydrogenase
-
AHD-M1
-
-
-
-
ALDDH
-
-
-
-
aldehyde dehydrogenase 3A1
-
-
aldehyde dehydrogenase 7A1
-
-
Aldehyde dehydrogenase [NAD+]
-
-
-
-
Aldehyde dehydrogenase, cytosolic
-
-
-
-
Aldehyde dehydrogenase, microsomal
-
-
-
-
aldehyde:NAD+ oxidoreductase
-
-
-
-
ALDH
-
-
ALDH-E1
-
-
-
-
ALDH-E2
-
-
-
-
ALDH1
ALDH1-NL
-
-
-
-
ALDH1A1
isozyme
Aldh1a7
isozyme
Aldh1b1
ALDH3A1
ALDH3A2
isozyme
Aldh7a1
Aldh8a1
isozyme
ALDHI
-
-
-
-
ALDHX
-
-
-
-
ALHDII
-
-
-
-
Allergen Alt a 10
-
-
-
-
Brassica turgor-responsive/drought-induced gene 26 protein
-
-
-
-
Btg-26
-
-
-
-
class I ALDH
-
-
CoA-independent aldehyde dehydrogenase
-
-
-
-
ETA-crystallin
-
-
-
-
gamma-aminobutyraldehyde dehydrogenase
-
-
-
-
K(+)-ACDH
-
-
-
-
K(+)-activated acetaldehyde dehydrogenase
-
-
-
-
m-methylbenzaldehyde dehydrogenase
-
-
-
-
Matured fruit 60 kDa protein
-
-
-
-
MF-60
-
-
-
-
Mg(2+)-ACDH
-
-
-
-
Mg(2+)-activated acetaldehyde dehydrogenase
-
-
-
-
NAD+-linked aldehyde dehydrogenase
-
-
-
-
NAD-aldehyde dehydrogenase
-
-
-
-
NAD-dependent 4-hydroxynonenal dehydrogenase
-
-
-
-
NAD-dependent aldehyde dehydrogenase
-
-
-
-
NAD-linked aldehyde dehydrogenase
-
-
-
-
Non-lens ALDH1
-
-
-
-
P51
-
-
-
-
PM-ALDH9
-
-
-
-
propionaldehyde dehydrogenase
-
-
-
-
R-aminobutyraldehyde dehydrogenase
-
-
-
-
RALDH
-
-
-
-
RALDH(II)
-
-
-
-
RalDH1
-
-
-
-
Retinal dehydrogenase
-
-
-
-
Turgor-responsive protein 26G
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
reduction
SYSTEMATIC NAME
IUBMB Comments
aldehyde:NAD+ oxidoreductase
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-86-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-hydroxy-2-nonenal + NAD+ + H2O
4-hydroxy-2-nonenoate + NADH + H+
show the reaction diagram
-
-
-
?
4-hydroxy-2-nonenal + NAD+ + H2O
4-hydroxynon-2-enoic acid + NADH
show the reaction diagram
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
-
-
-
?
malondialdehyde + NAD+ + H2O
?
show the reaction diagram
-
-
-
?
4-hydroxy-2-nonenal + NAD+ + H2O
4-hydroxynon-2-enoic acid + NADH
show the reaction diagram
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
malondialdehyde + NAD+ + H2O
?
show the reaction diagram
-
-
-
?
additional information
?
-
-
Aldh3a1 metabolizes toxic aldehydes produced by light-induced lipid peroxidation
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-hydroxy-2-nonenal + NAD+ + H2O
4-hydroxynon-2-enoic acid + NADH
show the reaction diagram
-
-
-
?
malondialdehyde + NAD+ + H2O
?
show the reaction diagram
-
-
-
?
4-hydroxy-2-nonenal + NAD+ + H2O
4-hydroxynon-2-enoic acid + NADH
show the reaction diagram
malondialdehyde + NAD+ + H2O
?
show the reaction diagram
-
-
-
?
additional information
?
-
-
Aldh3a1 metabolizes toxic aldehydes produced by light-induced lipid peroxidation
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Oct1
-
activates gene expression of the corneal crystallin Aldh3a1
-
p300
-
activates gene expression of the corneal crystallin Aldh3a1
-
Pax6
-
activates gene expression of the corneal crystallin Aldh3a1
-
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.7
precursor protein, isoelectric focusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
highest ALDH7A1 expression
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
decreased ALDH3A1 activity is associated with pathologic corneas (cataract development)
metabolism
isoform ALDH3A1 may exhibit antioxidant activity indirectly by producing NADH during metabolism
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ALDH2_MOUSE
519
0
56538
Swiss-Prot
Mitochondrion (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
58000
-
determined by SDS-PAGE and Western Blot analysis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
isoform ALDH3A1
homotetramer
isoform ALDH1B1
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
corneal epithelial extracts are prepared
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Aldh3a1 promoter fragments are constructed and subcloned into the pGL3 basic vector
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
isoform ALDH3A1 protein and mRNA levels increase substantially in mouse cornea by postnatal day 14
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Alnouti, Y.; Klaassen, C.D.
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice
Toxicol. Sci.
101
51-64
2008
Mus musculus (O35945), Mus musculus (P47738), Mus musculus (P47740), Mus musculus (Q8BH00), Mus musculus (Q9CZS1)
Manually annotated by BRENDA team
Pearce, D.J.; Bonnet, D.
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells
Exp. Hematol.
35
1437-1446
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Westerlund, M.; Belin, A.C.; Felder, M.R.; Olson, L.; Galter, D.
High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinsons disease
FEBS J.
274
1212-1223
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Cahill, M.A.; Vogt, J.A.; Servos, J.; Wozny, W.; Schwall, G.P.; Groebe, K.; Schrattenholz, A.; Stegmann, W.
Metabolically stable isotope labeling prior to electrophoretic protein separation reveals differences in fractional synthesis rates between mitochondrial aldehyde dehydrogenase isoforms
J. Chromatogr. A
1161
67-70
2007
Mus musculus (P47738)
Manually annotated by BRENDA team
Ohsawa, I.; Nishimaki, K.; Murakami, Y.; Suzuki, Y.; Ishikawa, M.; Ohta, S.
Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity
J. Neurosci.
28
6239-6249
2008
Mus musculus (P47738), Mus musculus
Manually annotated by BRENDA team
Davis, J.; Davis, D.; Norman, B.; Piatigorsky, J.
Gene expression of the mouse corneal crystallin Aldh3a1: activation by Pax6, Oct1, and p300
Invest. Ophthalmol. Vis. Sci.
49
1814-1826
2008
Mus musculus
Manually annotated by BRENDA team
Stagos, D.; Chen, Y.; Cantore, M.; Jester, J.V.; Vasiliou, V.
Corneal aldehyde dehydrogenases: multiple functions and novel nuclear localization
Brain Res. Bull.
81
211-218
2010
Oryctolagus cuniculus, Mus musculus (P47738), Mus musculus (Q3UNF5), Mus musculus (Q9CZS1), Mus musculus (Q9DBF1), Mus musculus
Manually annotated by BRENDA team
Brocker, C.; Lassen, N.; Estey, T.; Pappa, A.; Cantore, M.; Orlova, V.V.; Chavakis, T.; Kavanagh, K.L.; Oppermann, U.; Vasiliou, V.
Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress
J. Biol. Chem.
285
18452-18463
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team