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The taxonomic range for the selected organisms is: Helicobacter pylori
The enzyme appears in selected viruses and cellular organisms
Synonyms
asadh, aspartate semialdehyde dehydrogenase, aspartate-beta-semialdehyde dehydrogenase, aspartate-semialdehyde dehydrogenase, aspartate beta-semialdehyde dehydrogenase, asa dh, aspartic semialdehyde dehydrogenase, l-aspartate-beta-semialdehyde dehydrogenase, asd enzyme, ecasadh,
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ASA dehydrogenase
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aspartate semialdehyde dehydrogenase
aspartate-semialdehyde dehydrogenase
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aspartic beta-semialdehyde dehydrogenase
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aspartic semialdehyde dehydrogenase
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aspartyl semialdehyde dehydrogenase
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dehydrogenase, aspartate semialdehyde
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L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosphorylating)
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aspartate semialdehyde dehydrogenase
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aspartate semialdehyde dehydrogenase
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-, -, -, -, -, -, -, -, -, -, -, -, -, -
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L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
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L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
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L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH
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r
L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
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L-4-aspartyl phosphate + NADPH
L-aspartate 4-semialdehyde + phosphate + NADP+
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L-aspartate 4-semialdehyde + phosphate + NADP+
L-4-aspartyl phosphate + NADPH + H+
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petrosamine B
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50% inhibition at 0.306 mM. Petrosamine B is a pyridoacridine alkaloid isolated from the sponge Oceanapia sp.
petrosamine B
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isolated from the methanol extract of the saustralian sponge Oceanapia sp.
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0.306
petrosamine B
Helicobacter pylori
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Uniprot
brenda
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Ni-affinity chromatography
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expressed as inclusion bodies with an N-terminal hexahistidine tag in pET28b vector or subcloned into pET41 vector with NdeI/SalI
expression in Escherichia coli
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medicine
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target for antibiotic development
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Moore, R.A.; Bocik, W.E.; Viola, R.E.
Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms
Protein Expr. Purif.
25
189-194
2002
Haemophilus influenzae, Helicobacter pylori (O25801), Helicobacter pylori, Pseudomonas aeruginosa (Q51344), Pseudomonas aeruginosa, Vibrio cholerae (P23247), Vibrio cholerae
brenda
Carroll, A.R.; Ngo, A.; Quinn, R.J.; Redburn, J.; Hooper, J.N.
Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp
J. Nat. Prod.
68
804-806
2005
Helicobacter pylori
brenda
1.2.1.11 aspartate-semialdehyde dehydrogenase
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