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Disease on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Impact of CYP2C9 and VKORC1 genetic polymorphisms upon warfarin dose requirements in Egyptian patients with acute coronary syndrome.
Anemia
Revalidation of CoaguChek XS plus system for INR monitoring in Taiwanese patients: effects of clinical and genetic factors.
Aneurysm
The VKORC1 polymorphism rs9923231 is associated with aneurysms of the ascending aorta in an Austrian population.
Aneurysm, Dissecting
Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
Atherosclerosis
Association of VKORC1 -1639 G>A polymorphism with carotid intima-media thickness in type 2 diabetes mellitus.
Relationship between VKORC1 single nucleotide polymorphism 1173C>T, bone mineral density & carotid intima-media thickness.
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification.
Atrial Fibrillation
A new algorithm to predict warfarin dose from polymorphisms of CYP4F2 , CYP2C9 and VKORC1 and clinical variables: derivation in Han Chinese patients with non valvular atrial fibrillation.
Clinical and genetic factors influencing acenocoumarol dosing: a cross-sectional study.
Clinical application of a new warfarin-dosing regimen based on the CYP2C9 and VKORC1 genotypes in atrial fibrillation patients.
Comparison of aspirin and Naoxintong Capsule () with adjusted-dose warfarin in elderly patients with high-risk of non-valvular atrial fibrillation and genetic variants of vitamin K epoxide reductase.
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
DNA sensors to assess the effect of VKORC1 and CYP2C9 gene polymorphisms on warfarin dose requirement in Chinese patients with atrial fibrillation.
Factors affecting the interindividual variability of warfarin dose requirement in adult Korean patients.
Genetic causes of resistance to vitamin K antagonists in Polish patients: a novel p.Ile123Met mutation in VKORC1 gene.
Genetic variant in the promoter region of microRNA?137 reduces the warfarin maintenance dose in patients with atrial fibrillation.
Impact of VKORC1, CYP4F2 and NQO1 gene variants on warfarin dose requirement in Han Chinese patients with catheter ablation for atrial fibrillation.
Incidence, mortality, and risk factors for oral anticoagulant-associated intracranial hemorrhage in patients with atrial fibrillation.
Performance Evaluation of Warfarin Dose Prediction Algorithms and Effects of Clinical Factors on Warfarin Dose in Chinese Patients.
Pharmacogenetics of vitamin K antagonists and bleeding risk prediction in atrial fibrillation.
Pharmacogenetics role in the safety of acenocoumarol therapy.
Polymorphisms of CYP2C9*2, CYP2C9*3 and VKORC1 genes related to time in therapeutic range in patients with atrial fibrillation using warfarin.
Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm.
Quantifying the Effect of Covariates on Concentrations and Effects of Steady-State Phenprocoumon Using a Population Pharmacokinetic/Pharmacodynamic Model.
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
Warfarin dose requirement with different genotypes of polymorphisms on CYP2C9 and VKORC1 and indications in Han-Chinese patients.
Warfarin dosing according to the genotype-guided algorithm is most beneficial in patients with atrial fibrillation: a randomized parallel group trial.
Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients.
[Association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation in ethnic Uygurs and Hans from Xinjiang].
Bone Diseases, Metabolic
Relationship between VKORC1 single nucleotide polymorphism 1173C>T, bone mineral density & carotid intima-media thickness.
Breast Neoplasms
Challenges and pitfalls in the introduction of pharmacogenetics for cancer.
Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells.
Budd-Chiari Syndrome
Mutations in CYP2C9 and/or VKORC1 haplotype are associated with higher bleeding complications in patients with Budd-Chiari syndrome on warfarin.
Carcinoma, Hepatocellular
mTOR and ERK regulate VKORC1 expression in both hepatoma cells and hepatocytes which influence blood coagulation.
Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum.
VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma.
Cardiovascular Diseases
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
Missense mutation of VKORC1 leads to medial arterial calcification in rats.
Pharmacogenetics of Anticoagulation and Clinical Events in Warfarin-Treated Patients: A Register-Based Cohort Study with Biobank Data and National Health Registries in Finland.
Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney disease.
VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.
Cerebrovascular Disorders
Association Between VKORC1 Gene Polymorphisms and Ischemic Cerebrovascular Disease in Chinese Han Population.
Pharmacogenetic Testing for Guiding de novo Phenprocoumon Therapy in Stroke Patients.
VKORC1 and CD-14 genetic polymorphisms associate with susceptibility to cardiovascular and cerebrovascular diseases.
VKORC1 rs2359612 and rs9923231 polymorphisms correlate with high risks of cardiovascular and cerebrovascular diseases.
Chondrodysplasia Punctata
Binder phenotype: associated findings and etiologic mechanisms.
Congenital Abnormalities
A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis.
Coronary Artery Disease
VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification.
Coronary Disease
Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.
Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease.
Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population.
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
COVID-19
Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection.
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes.
Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene polymorphism as determinant of differences in Covid-19-related disease severity.
Dementia
Variation in VKORC1 Is Associated with Vascular Dementia.
Dementia, Vascular
Variation in VKORC1 Is Associated with Vascular Dementia.
Diabetes Mellitus
Association of VKORC1 -1639 G>A polymorphism with carotid intima-media thickness in type 2 diabetes mellitus.
Clinical Predictors Associated With Warfarin Sensitivity.
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Role of the Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) -1639G>A Gene Polymorphism in Patients with Retinal Vein Occlusion.
Diabetes Mellitus, Type 2
Association of VKORC1 -1639 G>A polymorphism with carotid intima-media thickness in type 2 diabetes mellitus.
Lack of Association Between Type 2 Diabetes and the 3673G / A and 9041G / A Gene Variants of Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1).
Drug-Related Side Effects and Adverse Reactions
Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin.
Pharmacogenetics of Anticoagulation and Clinical Events in Warfarin-Treated Patients: A Register-Based Cohort Study with Biobank Data and National Health Registries in Finland.
Warfarin Dosing in a Patient with CYP2C9(?)3(?)3 and VKORC1-1639 AA Genotypes.
Dyslipidemias
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Embolic Stroke
Warfarin loading dose guided by pharmacogenetics is effective and safe in cardioembolic stroke patients - a randomized, prospective study.
Embolism
Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients.
Essential Hypertension
Susceptiveness of Vitamin K epOxide Reductase Complex Subunit 1 Gene Polymorphism in Essential Hypertension.
Fetal Diseases
A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis.
Male infant with ichthyosis, Kallmann syndrome, chondrodysplasia punctata, and an Xp chromosome deletion.
Heart Diseases
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Genetic and clinical determinants influencing warfarin dosing in children with heart disease.
Vitamin K antagonists in children with heart disease: height and VKORC1 genotype are the main determinants of the warfarin dose requirement.
Heart Failure
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Pharmacogenetic-guided Warfarin Dosing Algorithm in African-Americans.
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
Heart Valve Diseases
Prevalence of CYP2C9 and VKORC1 mutation in patients with valvular heart disease in northern Thailand.
VKORC1 -1639G/A and 1173 C/T Genetic Polymorphisms Influence Individual Differences in Warfarin Maintenance Dose.
Hepatitis B
Seven novel probe systems for real-time PCR provide absolute single-base discrimination, higher signaling, and generic components.
VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma.
Hypersensitivity
Methodological and statistical issues in pharmacogenomics.
Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report.
[Impact of pharmacogenetics on interindividual variability in the response to vitamin K antagonist therapy]
[Resistance to acenocoumarol revealing a missense mutation of the vitamin K epoxyde reductase VKORC1: A case report.]
Hypertension
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Role of the Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) -1639G>A Gene Polymorphism in Patients with Retinal Vein Occlusion.
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
Hypoalbuminemia
Revalidation of CoaguChek XS plus system for INR monitoring in Taiwanese patients: effects of clinical and genetic factors.
Hypoprothrombinemias
Depression of liver microsomal vitamin K epoxide reductase activity associated with antibiotic-induced coagulopathy.
Effect of N-methyl-thiotetrazole on vitamin K epoxide reductase.
Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status.
[Hemostasis disturbance caused by cephalosporins with an N-methylthiotetrazole side chain. A randomized pilot study]
Influenza, Human
Seven novel probe systems for real-time PCR provide absolute single-base discrimination, higher signaling, and generic components.
Ischemic Stroke
Association of functional VKORC1 promoter polymorphism with occurrence and clinical aspects of ischemic stroke in a Greek population.
Effect of CYP2C9 *11/*11 genotype on initial and long-term warfarin dose requirement and therapeutic response.
G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population.
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.
Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population.
Kidney Failure, Chronic
Clinical and genetic factors influencing acenocoumarol dosing: a cross-sectional study.
Lupus Erythematosus, Systemic
Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians.
Lymphoma
Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
Lymphoma, Primary Effusion
Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
Mucocutaneous Lymph Node Syndrome
Height, VKORC1 1173, and CYP2C9 Genotypes Determine Warfarin Dose for Pediatric Patients with Kawasaki Disease in Southwest China.
Muscular Diseases
[Pharmacogenomics in routine medical care]
Myocardial Infarction
Genetic variation of VKORC1 and CYP4F2 genes related to warfarin maintenance dose in patients with myocardial infarction.
Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.
Myocardial Ischemia
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Myxoma
A rare combination of CYP2C9*3/*3 and VKORC1 1639AA in a patient had myxoma and thromboembolism.
Neoplasms
Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells.
Effects of inflammatory cytokine gene polymorphisms on warfarin maintenance doses in Korean patients with mechanical cardiac valves.
Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients.
Pharmacogenomics: from bedside to clinical practice.
The point mutation analysis of Cyp2C9*2 (Arg144Cys C>T), Cyp2C9*3 (Ile359Leu A>C) and VKORC1 (1639G>A) in women with cervical cancer related to HPV: A case-control study.
VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma.
Neuroblastoma
Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients.
Obesity
CYP4F2 and VKORC1 Polymorphisms Amplify the Risk of Carotid Plaque Formation.
Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population.
The Impact of Body Mass Index and Genetics on Warfarin Major Bleeding Outcomes in a Community Setting.
The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice.
Osteoporosis
Association Between Vitamin K Epoxide Reductase (VKORC1) -1639G>A Polymorphism and Osteoporosis in Postmenopausal Women.
Genetic Variation in VKORC1 and Risk for Osteoporosis.
Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study.
Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women.
Relationship between VKORC1 single nucleotide polymorphism 1173C>T, bone mineral density & carotid intima-media thickness.
Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study.
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.
Osteoporosis, Postmenopausal
Association Between Vitamin K Epoxide Reductase (VKORC1) -1639G>A Polymorphism and Osteoporosis in Postmenopausal Women.
Peripheral Arterial Disease
No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease.
Prostatic Neoplasms
Serum undercarboxylated osteocalcin as biomarker of vitamin K intake and risk of prostate cancer: a nested case-control study in the Heidelberg cohort of the European prospective investigation into cancer and nutrition.
Vitamin K epoxide reductase expression and prostate cancer risk.
Pulmonary Embolism
ARMS test for diagnosis of CYP2C9 and VKORC1 mutation in patients with pulmonary embolism in Han Chinese.
Comparison of rivaroxaban mono-therapy and standard-therapy adjusted by CYP2C9 and VKORC1 genotypes in symptomatic pulmonary embolism.
Pulmonary Fibrosis
VKORC1 and CYP2C9 Polymorphisms: A Case Report in a Dutch Family with Pulmonary Fibrosis.
Renal Insufficiency, Chronic
Race influences warfarin dose changes associated with genetic factors.
Sequence variation in vitamin K epoxide reductase gene is associated with survival and progressive coronary calcification in chronic kidney disease.
VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.
Retinal Vein Occlusion
Predictive value of the vkorc1 g-1639a and vkorc1 c1173t single nucleotide polymorphisms in retinal vein occlusion.
Role of the Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) -1639G>A Gene Polymorphism in Patients with Retinal Vein Occlusion.
Rheumatic Heart Disease
Clinical application of pharmacogenetic-based warfarin-dosing algorithm in patients of han nationality after rheumatic valve replacement: a randomized and controlled trial.
Stroke
Clinical Application of Genotype-guided Dosing of Warfarin in Patients with Acute Stroke.
Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.
Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.
Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain.
Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke.
Incidence, mortality, and risk factors for oral anticoagulant-associated intracranial hemorrhage in patients with atrial fibrillation.
Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics.
Prevalence of genetic polymorphisms of CYP2C9 and VKORC1 - implications for warfarin management and outcome in Croatian patients with acute stroke.
Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population.
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
Utilizing Whole-Exome Sequencing to Characterize the Phenotypic Variability of Sickle Cell Disease.
VKORC1 and CYP2C9 Genotype Variations in Relation to Warfarin Dosing in Korean Stroke Patients.
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
Thromboembolism
A rare combination of CYP2C9*3/*3 and VKORC1 1639AA in a patient had myxoma and thromboembolism.
Comparison of aspirin and Naoxintong Capsule () with adjusted-dose warfarin in elderly patients with high-risk of non-valvular atrial fibrillation and genetic variants of vitamin K epoxide reductase.
Thrombophilia
Increased warfarin consumption and residual fibrin turnover in thrombotic patients with primary antiphospholipid syndrome.
Population study of thrombophilic markers and pharmacogenetic markers of warfarin prevalence in Bosnia and Herzegovina.
Warfarin dose requirement in patients having severe thrombosis or thrombophilia.
Thrombosis
A new cell culture-based assay quantifies VKORC1 function and reveals warfarin resistance phenotypes not shown by the DTT-driven VKOR assay.
An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol.
Antithrombotic Activity of the Novel Oral Anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in Animal Models.
Challenges and pitfalls in the introduction of pharmacogenetics for cancer.
Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin.
Polymorphisms of CYP2C9, VKORC1, MDR1, APOE and UGT1A1 genes and the therapeutic warfarin dose in Brazilian patients with thrombosis: a prospective cohort study.
Prosthetic valve thrombosis - association of genetic polymorphisms of VKORC1, CYP2C9 and CYP4F2 genes.
Synthesis and structure-activity relationships of novel warfarin derivatives.
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
Thrombotic genetic risk factors and warfarin pharmacogenetic variants in São Miguel's healthy population (Azores).
Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.
VKORC1 -1639 G>A Polymorphism in Romanian Patients With Deep Vein Thrombosis.
VKORC1 and CYP2C9 genetic polymorphisms in hepatic or portal vein thrombosis.
VKORC1 and CYP2C9 genotypes in Egyptian patients with warfarin resistance.
VKORC1 and the vitamin K cycle.
VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites.
VKORC1 C1173T and VKORC1 G-1639A Gene Polymorphisms in Turkish Behçet's Patients with Ocular and Non-ocular Involvement.
Warfarin dose requirement in patients having severe thrombosis or thrombophilia.
[Factors associated with thrombosis of the left atrial appendage in patients with chronic atrial fibrillation].
[FREQUENCY OF POLYMORPHISM OF VKORC1 AND CYP2C9 GENES IN TWO REGIONS OF GEORGIA].
Triple Negative Breast Neoplasms
Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells.
Tuberculosis
Alanine dehydrogenases in mycobacteria.
Membrane Topology and Mutational Analysis of Mycobacterium tuberculosis VKOR, a Protein Involved in Disulfide Bond Formation and a Homologue of Human Vitamin K Epoxide Reductase.
Mycobacterium tuberculosis vitamin K epoxide reductase homologue supports vitamin K-dependent carboxylation in mammalian cells.
Seven novel probe systems for real-time PCR provide absolute single-base discrimination, higher signaling, and generic components.
Urolithiasis
Decreased expression of vitamin K epoxide reductase complex subunit 1 in kidney of patients with calcium oxalate urolithiasis.
Involvement of VKORC1 in the inhibition of calcium oxalate crystal formation in HK-2 cells.
Re: Decreased expression of vitamin k epoxide reductase complex subunit 1 in kidney of patients with calcium oxalate urolithiasis.
Uterine Cervical Neoplasms
The point mutation analysis of Cyp2C9*2 (Arg144Cys C>T), Cyp2C9*3 (Ile359Leu A>C) and VKORC1 (1639G>A) in women with cervical cancer related to HPV: A case-control study.
Varicose Veins
VKORC1 -1639 G>A Polymorphism in Romanian Patients With Deep Vein Thrombosis.
Vascular Calcification
Association of functional VKORC1 promoter polymorphism with occurrence and clinical aspects of ischemic stroke in a Greek population.
Decreased expression of ?-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein.
Missense mutation of VKORC1 leads to medial arterial calcification in rats.
Relationship between VKORC1 single nucleotide polymorphism 1173C>T, bone mineral density & carotid intima-media thickness.
Vitamin K epoxide reductase complex and vascular calcification: is this the important link between vitamin K and the arterial vessel wall?
VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.
Vascular Diseases
Impact of VKORC1 haplotypes on long-term graft function in kidney transplantation.
Vitamin K epoxide reductase complex subunit 1 gene polymorphism is associated with atherothrombotic complication after drug-eluting stent implantation: 2-Center prospective cohort study.
Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study.
VKORC1 haplotypes are associated with arterial vascular diseases (stroke, coronary heart disease, and aortic dissection).
Venous Thromboembolism
A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism.
Frequency of vitamin K oxidoreductase complex subunit-1 (VKORC1) polymorphisms and warfarin dose management in patients with venous thromboembolism.
Pharmacogenetics role in the safety of acenocoumarol therapy.
Prediction of stable acenocoumarol dose by a pharmacogenetic algorithm.
Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study.
VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients.
VKORC1 genetic polymorphism and risk of venous thromboembolism in postmenopausal women: new findings and metaanalysis.
Venous Thrombosis
Common VKORC1 variants are not associated with arterial or venous thrombosis.
Genotyping of CYP2C9 and VKORC1 polymorphisms predicts south Indian patients with deep vein thrombosis as fast metabolizers of warfarin/acenocoumarin.
Haplotypes of VKORC1, NQO1 and GGCX, their effect on activity levels of vitamin K-dependent coagulation factors, and the risk of venous thrombosis.
No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease.
Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population.
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
VKORC1 -1639 G>A Polymorphism in Romanian Patients With Deep Vein Thrombosis.
VKORC1 and CYP2C9 genotypes in Egyptian patients with warfarin resistance.
VKORC1 gene variation and venous thrombosis: 'another one bites the dust'?
Vitamin K Deficiency
Understand variability of COVID-19 through population and tissue variations in expression of SARS-CoV-2 host genes.
[Vitamin K deficiency syndrome caused by antituberculous agents]
[Vitamin K]
vitamin-k-epoxide reductase (warfarin-sensitive) deficiency
A novel role for vitamin K1 in a tyrosine phosphorylation cascade during chick embryogenesis.
Binder phenotype: associated findings and etiologic mechanisms.
Male infant with ichthyosis, Kallmann syndrome, chondrodysplasia punctata, and an Xp chromosome deletion.
The Vitamin K Epoxide Reductase Vkorc1l1 Promotes Preadipocyte Differentiation in Mice.
VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.