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Reference on EC 1.17.4.2 - ribonucleoside-triphosphate reductase (thioredoxin)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bakley, R.L.
Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii
J. Biol. Chem.
240
2173-2180
1965
Lactobacillus leichmannii
Manually annotated by BRENDA team
Goulian, M.; Beck, W.S.
Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii
J. Biol. Chem.
241
4233-4242
1966
Lactobacillus leichmannii
Manually annotated by BRENDA team
Sando, G.N.; Hogenkamp, H.P.C.
Ribonucleotide reductase from Thermus X-1, a thermophilic organism
Biochemistry
12
3316-3322
1973
Lactobacillus leichmannii, Thermus aquaticus, Thermus sp., Thermus sp. X-1, Thermus aquaticus YT-1
Manually annotated by BRENDA team
Chen, A.K.; Bhan, A.; Hopper, S.; Abrams, R.; Franzen, J.S.
Substrate and effector binding to ribonucleoside triphosphate reductase of Lactobacillus leichmannii
Biochemistry
13
654-661
1974
Lactobacillus leichmannii
Manually annotated by BRENDA team
Hamilton, F.D.
Ribonucleotide reductase from Euglena gracilis. A 5-deoxyadenoslycobalamin-dependent enzyme
J. Biol. Chem.
249
4428-4434
1974
Escherichia coli, Euglena gracilis, Lactobacillus leichmannii, Euglena gracilis Z
Manually annotated by BRENDA team
Blakley, R.L.
Ribonucleoside triphosphate reductase from Lactobacillus leichmannii
Methods Enzymol.
51
246-259
1978
Astasia sp., Clostridium sp., Corynebacterium sp., Euglena sp., Lactobacillus leichmannii, Pseudomonas sp., Rhizobium sp.
Manually annotated by BRENDA team
Gleason, F.K.; Frick, T.D.
Adenosylcobalamin-dependent ribonucleotide reductase from the blue-green alga, Anabaena sp. Purification and partial characterization
J. Biol. Chem.
255
7728-7733
1980
Anabaena sp., Escherichia coli, Lactobacillus leichmannii, Anabaena sp. 7119
Manually annotated by BRENDA team
Ashley, G.W.; Harris, G.; Stubbe, J.
The mechanism of Lactobacillus leichmannii ribonucleotide reductase. Evidence for 3 carbon-hydrogen bond cleavage and a unique role for coenzyme B12
J. Biol. Chem.
261
3958-3964
1986
Lactobacillus leichmannii
Manually annotated by BRENDA team
Halicky, P.; Kollarova, M.; Kois, P.; Zelinka, J.
Immobilization of ribonucleotide reductase from Streptomyces aureofaciens
Collect. Czech. Chem. Commun.
54
2528-2541
1989
Kitasatospora aureofaciens
Manually annotated by BRENDA team
Booker, S.; Licht, S.; Broderick, J.; Stubbe, J.
Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction
Biochemistry
33
12676-12685
1994
Lactobacillus leichmannii
Manually annotated by BRENDA team
Jordan, A.; Torrents, E.; Jeanthon, C.; Eliasson, R.; Hellman, U.; Wernstedt, C.; Barbe, J.; Gibert, I.; Reichard, P.
B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli
Proc. Natl. Acad. Sci. USA
94
13487-13492
1997
Archaeoglobus fulgidus, Chloroflexus aurantiacus, Deinococcus radiodurans, Escherichia coli, Lactobacillus leichmannii, Methanocaldococcus jannaschii, Mycobacterium tuberculosis, Pyrococcus furiosus, Thermoplasma acidophilum, Thermotoga maritima, Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
Manually annotated by BRENDA team
Tauer, A.; Benner, S.A.
The B12-dependent ribonucleotide reductase from the archaebacterium Thermoplasma acidophila: an evolutionary solution to the ribonucleotide reductase conundrum
Proc. Natl. Acad. Sci. USA
94
53-58
1997
Anabaena sp., Escherichia coli, Halobacterium salinarum, Haloferax volcanii, Homo sapiens, Lactobacillus leichmannii, Mycobacterium tuberculosis, Thermoplasma acidophilum, Thermus aquaticus, Thermus aquaticus X1
Manually annotated by BRENDA team
Jordan, A.; Torrents, E.; Sala, I.; Hellman, U.; Gibert, I.; Reichard, P.
Ribonucleotide reduction in Pseudomonas species: simultaneous presence of active enzymes from different classes
J. Bacteriol.
181
3974-3980
1999
Brevundimonas diminuta, Brevundimonas vesicularis, Burkholderia cepacia, Delftia acidovorans, Deinococcus radiodurans, Escherichia coli, Hydrogenophaga flava, Lactobacillus leichmannii, Paracoccus denitrificans, Mycobacterium tuberculosis, Pseudomonas sp., Pseudomonas aeruginosa, Pseudomonas putida, Stenotrophomonas maltophilia, Pseudomonas stutzeri, Ralstonia pickettii, Xanthomonas campestris
Manually annotated by BRENDA team
Licht, S.S.; Booker, S.; Stubbe, J.
Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation
Biochemistry
38
1221-1233
1999
Escherichia coli, Lactobacillus leichmannii
Manually annotated by BRENDA team
Licht, S.S.; Lawrence, C.C.; Stubbe, J.
Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: The importance of entropy in catalysis
Biochemistry
38
1234-1242
1999
Lactobacillus leichmannii
Manually annotated by BRENDA team
Suto, R.K.; Poppe, L.; Retey, J.; Finke, R.G.
Ribonucleoside triphosphate reductase from Lactobacillus leichmannii: Kinetic evaluation of a series of adenosylcobalamin competitive inhibitors, [omega-(adenosin-5'-O-yl)alkyl]cobalamins, which mimic the post Co-C homolysis intermediate
Bioorg. Chem.
27
451-462
1999
Lactobacillus leichmannii
-
Manually annotated by BRENDA team
Suto, R.K.; Whalen, M.A.; Finke, R.G.
Adenosylcobalamin-dependent ribonucleoside triphosphate reductase from Lactobacillus leichmannii. Rapid, improved purification involving dGTP-based affinity chromatography plus biophysical characterization studies demonstrating enhanced, crystallographic level purity
Prep. Biochem. Biotechnol.
29
273-309
1999
Lactobacillus leichmannii
Manually annotated by BRENDA team
Chabes, A.; Domkin, V.; Larsson, G.; Liu, A.; Graslund, A.; Wijmenga, S.; Thelander, L.
Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit
Proc. Natl. Acad. Sci. USA
97
2474-2479
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hoegbom, M.; Huque, Y.; Sjoeberg, B.M.; Nordlund, P.
Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes
Biochemistry
41
1381-1389
2002
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Chen, D.; Abend, A.; Stubbe, J.; Frey, P.A.
Epimerization at carbon-5' of (5'R)-[5'-2H]adenosylcobalamin by ribonucleoside triphosphate reductase: cysteine 408-independent cleavage of the Co-C5'-bond
Biochemistry
42
4578-4584
2003
Lactobacillus leichmannii
Manually annotated by BRENDA team
Torrents, E.; Poplawski, A.; Sjoberg, B.M.
Two proteins mediate class II ribonucleotide reductase activity in Pseudomonas aeruginosa: expression and transcriptional analysis of the aerobic enzymes
J. Biol. Chem.
280
16571-16578
2005
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Larsson, K.M.; Jordan, A.; Eliasson, R.; Reichard, P.; Logan, D.T.; Nordlund, P.
Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase
Nat. Struct. Mol. Biol.
11
1142-1149
2004
Thermotoga maritima
Manually annotated by BRENDA team
Logan, D.T.; Mulliez, E.; Larsson, K.M.; Bodevin, S.; Atta, M.; Garnaud, P.E.; Sjberg, B.M.; Fontecave, M.
A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase
Proc. Natl. Acad. Sci. USA
100
3826-3831
2003
Escherichia coli, Escherichia coli JM109
Manually annotated by BRENDA team
Liu, X.; Zhou, B.; Xue, L.; Shih, J.; Tye, K.; Qi, C.; Yen, Y.
The ribonucleotide reductase subunit M2B subcellular localization and functional importance for DNA replication in physiological growth of KB cells
Biochem. Pharmacol.
70
1288-1297
2005
Homo sapiens
Manually annotated by BRENDA team
Lin, Z.P.; Belcourt, M.F.; Carbone, R.; Eaton, J.S.; Penketh, P.G.; Shadel, G.S.; Cory, J.G.; Sartorelli, A.C.
Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress
Biochem. Pharmacol.
73
760-772
2007
Homo sapiens
Manually annotated by BRENDA team
Madlener, S.; Illmer, C.; Horvath, Z.; Saiko, P.; Losert, A.; Herbacek, I.; Grusch, M.; Elford, H.L.; Krupitza, G.; Bernhaus, A.; Fritzer-Szekeres, M.; Szekeres, T.
Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells
Cancer Lett.
245
156-162
2007
Homo sapiens
Manually annotated by BRENDA team
Camier, S.; Ma, E.; Leroy, C.; Pruvost, A.; Toledano, M.; Marsolier-Kergoat, M.C.
Visualization of ribonucleotide reductase catalytic oxidation establishes thioredoxins as its major reductants in yeast
Free Radic. Biol. Med.
42
1008-1016
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Pham, D.Q.; Kos, P.J.; Mayo, J.J.; Winzerling, J.J.
Regulation of the ribonucleotide reductase small subunit (R2) in the yellow fever mosquito, Aedes aegypti
Gene
372
182-190
2006
Aedes aegypti
Manually annotated by BRENDA team
Hakansson, P.; Hofer, A.; Thelander, L.
Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells
J. Biol. Chem.
281
7834-7841
2006
Mus musculus
Manually annotated by BRENDA team
Wang, C.; Liu, Z.
Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development
Plant Cell
18
350-365
2006
Arabidopsis thaliana, Arabidopsis thaliana (P0DKH2)
Manually annotated by BRENDA team
Garton, S.; Knight, H.; Warren, G.J.; Knight, M.R.; Thorlby, G.J.
crinkled leaves 8 - A mutation in the large subunit of ribonucleotide reductase - leads to defects in leaf development and chloroplast division in Arabidopsis thaliana
Plant J.
50
118-127
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Yau, S.; Wachsman, J.T.
The Bacillus megaterium ribonucleotide reductase: evidence for a B 12 coenzyme requirement
Mol. Cell. Biochem.
1
101-105
1973
Priestia megaterium, Priestia megaterium KM / ATCC 13632
Manually annotated by BRENDA team
Sigmond, J.; Kamphuis, J.A.; Laan, A.C.; Hoebe, E.K.; Bergman, A.M.; Peters, G.J.
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent
Biochem. Pharmacol.
73
1548-1557
2007
Homo sapiens
Manually annotated by BRENDA team
Cerqueira, N.M.; Fernandes, P.A.; Ramos, M.J.
Understanding ribonucleotide reductase inactivation by gemcitabine
Chemistry
13
8507-8515
2007
Escherichia coli
Manually annotated by BRENDA team
Saiko, P.; Ozsvar-Kozma, M.; Bernhaus, A.; Jaschke, M.; Graser, G.; Lackner, A.; Grusch, M.; Horvath, Z.; Madlener, S.; Krupitza, G.; Handler, N.; Erker, T.; Jaeger, W.; Fritzer-Szekeres, M.; Szekeres, T.
N-hydroxy-N-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine
Int. J. Oncol.
31
1261-1266
2007
Homo sapiens
Manually annotated by BRENDA team
Roca, I.; Ballana, E.; Panosa, A.; Torrents, E.; Gibert, I.
Fumarate and nitrate reduction (FNR) dependent activation of the Escherichia coli anaerobic ribonucleotide reductase nrdDG promoter
Int. Microbiol.
11
49-56
2008
Escherichia coli K-12
Manually annotated by BRENDA team
Odenike, O.M.; Larson, R.A.; Gajria, D.; Dolan, M.E.; Delaney, S.M.; Karrison, T.G.; Ratain, M.J.; Stock, W.
Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia
Invest. New Drugs
26
233-239
2008
Homo sapiens
Manually annotated by BRENDA team
Gojo, I.; Tidwell, M.L.; Greer, J.; Takebe, N.; Seiter, K.; Pochron, M.F.; Johnson, B.; Sznol, M.; Karp, J.E.
Phase I and pharmacokinetic study of triapine, a potent ribonucleotide reductase inhibitor, in adults with advanced hematologic malignancies
Leuk. Res.
31
1165-1173
2007
Homo sapiens
Manually annotated by BRENDA team
Karp, J.E.; Giles, F.J.; Gojo, I.; Morris, L.; Greer, J.; Johnson, B.; Thein, M.; Sznol, M.; Low, J.
A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloprol
Leuk. Res.
32
71-77
2008
Homo sapiens
Manually annotated by BRENDA team
Saiko, P.; Pemberger, M.; Horvath, Z.; Savinc, I.; Grusch, M.; Handler, N.; Erker, T.; Jaeger, W.; Fritzer-Szekeres, M.; Szekeres, T.
Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: inhibition of ribonucleotide reductase activity
Oncol. Rep.
19
1621-1626
2008
Homo sapiens
Manually annotated by BRENDA team
Lohman, G.J.; Gerfen, G.J.; Stubbe, J.
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2,2-difluoro-2-deoxycytidine 5-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical
Biochemistry
49
1396-1403
2010
Lactobacillus leichmannii
Manually annotated by BRENDA team
Lohman, G.J.; Stubbe, J.
Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification
Biochemistry
49
1404-1417
2010
Lactobacillus leichmannii
Manually annotated by BRENDA team
Holmgren, A.; Sengupta, R.
The use of thiols by ribonucleotide reductase
Free Radic. Biol. Med.
49
1617-1628
2010
Tequatrovirus T4, Escherichia coli, Mus musculus
Manually annotated by BRENDA team
Pontarin, G.; Ferraro, P.; Rampazzo, C.; Kollberg, G.; Holme, E.; Reichard, P.; Bianchi, V.
Deoxyribonucleotide metabolism in cycling and resting human fibroblasts with a missense mutation in p53R2, a subunit of ribonucleotide reductase
J. Biol. Chem.
286
11132-11140
2011
Homo sapiens
Manually annotated by BRENDA team
Logan, D.
Closing the circle on ribonucleotide reductases
Nat. Struct. Mol. Biol.
18
251-253
2011
Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Ylikallio, E.; Page, J.L.; Xu, X.; Lampinen, M.; Bepler, G.; Ide, T.; Tyynismaa, H.; Weiss, R.S.; Suomalainen, A.
Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice
Nucleic Acids Res.
38
8208-8218
2010
Mus musculus
Manually annotated by BRENDA team
Halimi, Y.; Dessau, M.; Pollak, S.; Ast, T.; Erez, T.; Livnat-Levanon, N.; Karniol, B.; Hirsch, J.; Chamovitz, D.
COP9 signalosome subunit 7 from Arabidopsis interacts with and regulates the small subunit of ribonucleotide reductase (RNR2)
Plant Mol. Biol.
77
77-89
2011
Arabidopsis thaliana (P50651), Arabidopsis thaliana (Q9LSD0), Arabidopsis thaliana Col-0 (P50651), Arabidopsis thaliana Col-0 (Q9LSD0)
Manually annotated by BRENDA team
Panosa, A.; Roca, I.; Gibert, I.
Ribonucleotide reductases of Salmonella typhimurium: transcriptional regulation and differential role in pathogenesis
PLoS ONE
5
e11328
2010
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Manzerova, J.; Krymov, V.; Gerfen, G.J.
Investigating the intermediates in the reaction of ribonucleoside triphosphate reductase from Lactobacillus leichmannii: An application of HF EPR-RFQ technology
J. Magn. Reson.
213
32-45
2011
Lactobacillus leichmannii (Q59490), Lactobacillus leichmannii
Manually annotated by BRENDA team
Alnajar, S.; Khadka, B.; Gupta, R.
Ribonucleotide reductases from bifidobacteria contain multiple conserved indels distinguishing them from all other organisms In silico analysis of the possible role of a 43 aa bifidobacteria-specific insert in the class III RNR homolog
Front. Microbiol.
8
1409
2017
Bifidobacterium longum
Manually annotated by BRENDA team
Aurelius, O.; Johansson, R.; Bagenholm, V.; Lundin, D.; Tholander, F.; Balhuizen, A.; Beck, T.; Sahlin, M.; Sjoeberg, B.M.; Mulliez, E.; Logan, D.T.
The crystal structure of Thermotoga maritima class III ribonucleotide reductase lacks a radical cysteine pre-positioned in the active site
PLoS ONE
10
e0128199
2015
Thermotoga maritima (Q9WYL6), Thermotoga maritima
Manually annotated by BRENDA team
Arnaoutov, A.; Dasso, M.
Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes
Science
345
1512-1515
2014
Homo sapiens
Manually annotated by BRENDA team