Reference on EC 1.17.4.1 - ribonucleoside-diphosphate reductase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kucera, R.; Paulus, H.
Studies on ribonucleoside-diphosphate reductase in permeable animal cells. II. Catalytic and regulatory properties of the enzyme in mouse L cells
Arch. Biochem. Biophys.
214
114-123
1982
Mus musculus
Moore, E.C.; Hurlbert, R.B.
Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors
J. Biol. Chem.
241
4802-4809
1966
Rattus norvegicus
Kjoller Larsen, I.; Sjberg, B.M.; Thelander, L.
Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues
Eur. J. Biochem.
125
75-81
1982
Tequatrovirus T4, Bos taurus, Escherichia coli, Mus musculus
Huszar, D.; Bacchetti, S.
Is ribonucleotide reductase the transforming function of herpes simplex virus 2?
Nature
302
77-79
1983
Herpes simplex virus
-
Berglund, O.
Ribonucleoside diphosphate reductase induced by bacteriophage Tr. I. Purification and characterization
J. Biol. Chem.
247
7270-7275
1972
Tequatrovirus T4
Berglund, O.
Ribonucleoside diphosphate reductase induced by bacteriophage T4. II. Allosteric regulation of substrate sepecificity and catalytic activity
J. Biol. Chem.
247
7276-7281
1972
Tequatrovirus T4
Thelander, L.; Sjberg, B.M.; Eriksson, S.
Ribonucleoside diphosphate reductase (Escherichia coli)
Methods Enzymol.
51
227-237
1978
Escherichia coli, Escherichia coli overproducing
Elford, H.L.; Van't Riet, B.; Wampler, G.L.; Lin, A.L.; Elford, R.M.
Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents
Adv. Enzyme Regul.
19
151-168
1981
Homo sapiens
Cory, J.G.; Sato, A.; Lasater, L.
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy
Adv. Enzyme Regul.
19
139-150
1981
Mus musculus
Mattaliano, R.J.; Sloan, A.M.; Plumer, E.R.; Klippenstein, G.L.
Purification of the two complementary subunits of ribonucleotide reductase from calf thymus
Biochem. Biophys. Res. Commun.
102
667-674
1981
Bos taurus
Averett, D.R.; Lubbers, C.; Elion, G.B.; Spector, T.
Ribonucleotide reductase induced by herpes simplex type 1 virus. Characterization of a distinct enzyme
J. Biol. Chem.
258
9831-9838
1983
Mesocricetus auratus
Lammers, M.; Follmann, H.
The ribonucleotide reductases - a unique group of metalloenzymes essential for cell proliferation
Struct. Bonding
54
27-91
1983
Tequatrovirus T4, Tequintavirus T5, Enterobacteria phage T6, Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Tetradesmus obliquus
-
Hards, R.G.; Wright, J.A.
Ribonucleotide reductase activity in intact mammalian cells: stimulation of enzyme activity by MgCl2, dithiothreitol, and several nucleotides
Arch. Biochem. Biophys.
231
9-16
1984
Cricetulus griseus
Sato, A.; Bacon, P.E.; Cory, J.G.
Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit
Adv. Enzyme Regul.
22
231-241
1984
Mus musculus
Joelson, T.; Uhlin, U.; Eklund, H.; Sjberg, B.M.; Hahne, S.; Karlsson, M.
Crystallization and preliminary crystallographic data of ribonucleotide reductase protein B2 from Escherichia coli
J. Biol. Chem.
259
9076-9077
1984
Escherichia coli
Slabaugh, M.B.; Johnson, T.L.; Mathews, C.K.
Vaccinia virus induces ribonucleotide reductase in primate cells
J. Virol.
52
507-514
1984
Platyrrhini
Spector, T.; Jones, T.E.
Herpes simplex type 1 ribonucleotide reductase. Mechanism studies with inhibitors
J. Biol. Chem.
260
8694-8697
1985
Herpes simplex virus
Salowe, S.P.; Stubbe, J.
Cloning, overproduction, and purification of the B2 subunit of ribonucleoside-diphosphate reductase
J. Bacteriol.
165
363-366
1986
Escherichia coli
Whitefield, J.F.; Sikorska, M.; Youdale, T.; Brewer, L.; Richards, R.; Walker, P.R.
Ribonucleotide reductase - new twists in an old tale
Adv. Enzyme Regul.
28
113-123
1989
Rattus norvegicus
carter, G.L.; Cory, J.G.
Selective resistance of L1210 cell lines to inhibitors directed at the subunits of ribonucleotide reductase
Adv. Enzyme Regul.
29
123-139
1989
Mus musculus
Sahlin, M.; Sjberg, B.M.; Backes, G.; Loehr, T.; Sanders-Loehr, J.
Activation of the iron-containing B2 protein of ribonucleotide reductase by hydrogen peroxide
Biochem. Biophys. Res. Commun.
167
813-818
1990
Escherichia coli
Smith, S.L.; Douglas, K.T.
Stereoselective, strong inhibition of ribonucleotide reductase from E. coli by cisplatin
Biochem. Biophys. Res. Commun.
162
715-723
1989
Escherichia coli
Harder, J.; Follmann, H.
Characterization of the free radical in a plant ribonucleotide reductase
FEBS Lett.
222
171-174
1987
Tetradesmus obliquus
-
Cory, J.G.; Sato, A.; Brown, N.C.
Protein properties of the subunits of ribonucleotide reductase and the specificity of the allosteric site(s)
Adv. Enzyme Regul.
25
3-19
1986
Mus musculus
Averett, D.R.; Furman, P.A.; Spector, T.
Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1
J. Virol.
52
981-983
1984
Herpes simplex virus
Hofmann, R.; Feller, W.; Pries, M.; Follmann, H.
Deoxyribonucleotide biosynthesis in green algae. Purification and characterization of ribonucleotide-diphosphate reductase from Scenedesmus obliquus
Biochim. Biophys. Acta
832
98-112
1985
Tetradesmus obliquus
-
Cory, J.G.; Rey, D.A.; Carter, G.L.; Bacon, P.E.
Nucleoside 5'-diphosphates as effectors of mammalian ribonucleotide reductase
J. Biol. Chem.
260
12001-12007
1985
Mus musculus
Sato, A.; Cory, J.G.
Differential sensitivities of the subunits of mammalian ribonucleotide reductase to proteases, sulfhydryl reagents, and heat
Arch. Biochem. Biophys.
244
572-579
1986
Mus musculus
Yang, F.D.; Spanevello, R.A.; Celiker, I.; Hirschmann, R.; Rubin, H.; Cooperman, B.S.
The carboxyl terminus heptapeptide of the R2 subunit of mammalian ribonucleotide reductase inhibits enzyme activity and can be used to purify the R1 subunit
FEBS Lett.
272
61-64
1990
Bos taurus
Stubbe, J.
Ribonucleotide reductases
Adv. Enzymol. Relat. Areas Mol. Biol.
63
349-419
1990
Escherichia coli, Herpes simplex virus, Mus musculus
Holmgren, A.
Regulation of ribonucleotide reductase
Curr. Top. Cell. Regul.
19
47-76
1981
Escherichia phage T2, Tequatrovirus T4, Tequintavirus T5, Enterobacteria phage T6, Bos taurus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Rattus norvegicus
Stubbe, J.
Ribonucleotide reductases: amazing and confusing
J. Biol. Chem.
265
5329-5332
1990
Escherichia coli
Larsson, A.; Reichard, P.
Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli
J. Biol. Chem.
241
2533-2539
1966
Escherichia coli
Thelander, L.
Physicochemical characterization of ribonucleoside diphosphate reductase from Escherichia coli
J. Biol. Chem.
248
4591-4601
1973
Escherichia coli
Nordlund, P.; Sjberg, B.M.; Eklund, H.
Three-dimensional structure of the free radical protein of ribonucleotide reductase
Nature
345
593-598
1990
Escherichia coli
Nordlund, P.; Uhlin, U.; Westergren, C.; Joelsen, T.; Sjberg, B.M.; Eklund, H.
New crystal forms of the small subunit of ribonucleotide reductase from Escherichia coli
FEBS Lett.
258
251-254
1989
Escherichia coli
Thelander, M.; Thelander, L.
Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new dominant marker gene
EMBO J.
8
2475-2479
1989
Mus musculus (P11157)
Caras, I.W.; Martin, D.W.
Molecular cloning of the cDNA for a mutant mouse ribonucleotide reductase M1 that produces a dominant mutator phenotype in mammalian cells
Mol. Cell. Biol.
8
2698-2704
1988
Mus musculus
Ribi, H.O.; Reichard, P.; Kornberg, R.D.
Two-dimensional crystals of enzyme-effector complexes: ribonucleotide reductase at 18-A resolution
Biochemistry
26
7974-7979
1987
Escherichia coli
Bunker, G.; Petersson, L.; Sjberg, B.M.; Sahlin, M.; Chance, M.; Chance, B.; Ehrenberg, A.
Extended X-ray absorption fine structure studies on the iron-containing subunit of ribonucleotide reductase from Escherichia coli
Biochemistry
26
4708-4716
1987
Escherichia coli
Thelander, L.; Berg, P.
Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase
Mol. Cell. Biol.
6
3433-3442
1986
Mus musculus
Vitols, E.; Bauer, V.A.; Stanbrough, E.C.
Ribonucleotide reductase from Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
41
71-77
1970
Saccharomyces cerevisiae, Herpes simplex virus
Hopper, S.
Ribonucleotide reductase of rabbit bone marrow. I. Purification, properties, and separation into two protein fractions
J. Biol. Chem.
247
3336-3340
1972
Oryctolagus cuniculus
Nikas, I.; McLauchlan, J.; Davison, A.J.; Taylor, W.R.; Clements, J.B.
Structural features of ribonucleotide reductase
Proteins Struct. Funct. Genet.
1
376-384
1986
Herpes simplex virus
Fitzgerald, G.B.; Rosowsky, A.; Wick, M.M.
Inhibition of ribonucleotide reductase by naturally occurring quinols from spores of Agaricus bisporus
Biochem. Biophys. Res. Commun.
120
1008-1014
1984
Mus musculus
Engstrm, Y.; Rozell, B.; Hansson, H.A.; Stemme, S.; Thelander, L.
Localization of ribonucleotide reductase in mammalian cells
EMBO J.
3
863-867
1984
Mus musculus, Rattus norvegicus
Reichard, P.; Ehrenberg, A.
Ribonucleotide reductase - a radical enzyme
Science
221
514-519
1983
Escherichia coli
Cook, K.S.; Greenberg, G.R.
Properties of Bacteriophage T4 ribonucleoside diphosphate reductase subunits coded by nrdA and nrdB mutants
J. Biol. Chem.
258
6064-6072
1983
Tequatrovirus T4
Stubbe, J.; Ator, M.; Krenitsky, T.
Mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Evidence for 3-C-H bond cleavage
J. Biol. Chem.
258
1625-1630
1983
Escherichia coli
Berglund, O.; Sjoberg, B.M.
Effect of hydroxyurea on T4 ribonucleotide reductase
J. Biol. Chem.
254
253-254
1979
Tequatrovirus T4
Atkin, C.L.; Thelander, L.; Reichard, P.; Lang, G.
Iron and free radical in ribonucleotide reductase. Exchange of iron and Mossbauer spectroscopy of the protein B2 subunit of the Escherichia coli enzyme
J. Biol. Chem.
248
7464-7472
1973
Escherichia coli
Sjberg, B.M.; Grslund, A.; Loehr, J.S.; Loehr, T.M.
Ribonucleotide reductase: a structural study of the dimeric iron site
Biochem. Biophys. Res. Commun.
94
793-799
1980
Escherichia coli
Petersson, L.; Grslund, A.; Ehrenberg, A.; Sjberg, B.M.; Reichard, P.
The iron center in ribonucleotide reductase from Escherichia coli
J. Biol. Chem.
255
6706-6712
1980
Escherichia coli
Kucera, R.; Paulus, H.
Studied on ribonucleoside-diphosphate reductase in permeable animal cells. I. Reversible permeabilization of mouse L cells with dextran sulfate
Arch. Biochem. Biophys.
214
102-113
1982
Mus musculus
Cory, J.G.; Fleischer, A.E.
The molecular weight of Ehrlich tumor cell ribonucleotide reductase and its subunits: effector-induced changes
Arch. Biochem. Biophys.
217
546-551
1982
Mus musculus
Youdale, T.; MacManus, J.P.; Whitefield, J.F.
Rat liver ribonucleotide reductase: separation, purification, and properties of two nonidentical subunits
Can. J. Biochem.
60
463-470
1982
Rattus norvegicus
Gudas, L.; Eriksson, S.; Ullman, B.; Martin, D.
Purification of a mutant ribonucleotide reductase from cultured mouse T-lymphoma cells
Adv. Enzyme Regul.
19
129-137
1981
Mus musculus
Huszar, S.; Bacchetti, S.
Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells
J. Virol.
37
580-588
1981
Herpes simplex virus
Engstrm, Y.; Eriksson, S.; Thelander, L.; Akerman, M.
Ribonucleotide reductase from calf thymus. Purification and properties
Biochemistry
18
2941-2948
1979
Bos taurus, Escherichia coli
Hopper, S.
Ribonucleotide reductase of rabbit bone marrow
Methods Enzymol.
51
237-246
1978
Oryctolagus cuniculus
Feller, W.; Follmann, H.
Ribonucleotide reductase activity in green algae
Biochem. Biophys. Res. Commun.
70
752-758
1976
Auxenochlorella pyrenoidosa, Tetradesmus obliquus
Elford, H.L.
Functional regulation of mammalian ribonucleotide reductase
Adv. Enzyme Regul.
10
19-38
1972
Rattus norvegicus
Larsson, A.
Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate
Biochim. Biophys. Acta
324
447-451
1973
Rattus norvegicus
Ong, S.P.; McFarlan, S.C.; Hogenkamp, H.P.C.
2'-C-Methyladenosine and 2'-C-methyluridine 5'-diphosphates are mechanism-based inhibitors of ribonucleoside diphosphate reductase from Corynebacterium nephridii
Biochemistry
32
11397-11404
1993
Corynebacterium nephridii
Slabaugh, M.B.; Davis, R.E.; Roseman, N.A.; Mathews, C.K.
Vaccinia virus ribonucleotide reductase expression and isolation of the recombinant large subunit
J. Biol. Chem.
268
17803-17810
1993
Vaccinia virus
Young, P.; Leeds, J.M.; Slabaugh, M.B.; Mathews, C.K.
Ribonucleotide reductase: evidence for specific association with HeLa cell mitochondria
Biochem. Biophys. Res. Commun.
203
46-52
1994
Homo sapiens
Jordan, A.; Pontis, E.; Atta, M.; Krook, M.; Gibert, I.; Barbe, J.; Reichard, P.
A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme
Proc. Natl. Acad. Sci. USA
91
12892-12896
1994
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Sinhababu, A.K.; Boehlert, C.C.; Gan, L.S.; Yanni, S.B.; Thakker, D.R.
High-performance liquid chromatographic purification, optimization of the assay, and properties of ribonucleoside diphosphate reductase from rabbit bone marrow
Arch. Biochem. Biophys.
317
285-291
1995
Oryctolagus cuniculus
Cory, J.G.; Cory, A.H.; Downes, D.L.
Differential substrate properties of mammalian ribonucleotide reductase
Purine and pyrimidine metabolism in man VIII ed. (Sahota A. and Taylor M. ed.)
631-635
1995
Mus musculus
-
Racay, P.; Kollarova, M.
Purification and partial characterization of Ca2+-dependent ribonucleotide reductase from Streptomyces aureofaciens
Biochem. Mol. Biol. Int.
38
493-500
1996
Kitasatospora aureofaciens
Hendricks, S.P.; Mathews, C.K.
Regulation of T4 phage aerobic ribonucleotide reductase. Simultaneous assay of the four activities
J. Biol. Chem.
272
2861-2865
1997
Tequatrovirus T4
Fieschi, F.; Torrents, E.; Toulokhonova, L.; Jordan, A.; Hellman, U.; Barbe, J.; Gibert, I.; Karlsson, M.; Sjoberg, B.M.
The manganese-containing ribonucleotide reductase of Corynebacterium ammoniagenes is a class Ib enzyme
J. Biol. Chem.
273
4329-4337
1998
Corynebacterium ammoniagenes (O69273)
Tong, W.; Burdi, D.; Riggs-Gelasco, P.; Chen, S.; Edmondson, D.; Huynh, V.; Stubbe, J.; Han, S.; Arvai, A.; Tainer, J.
Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography
Biochemistry
37
5840-5848
1998
Escherichia coli (P69924)
Hamann, C.S.; Lentainge, S.; Li, L.S.; Salem, J.S.; Yang, F.D.; Cooperman, B.S.
Chimeric small subunit inhibitors of mammalian ribonucleotide reductase: a dual function for the R2 C-terminus?
Protein Eng.
11
219-224
1998
Escherichia coli, Mus musculus
Nguyen, H.H.T.; Ge, J.; Perlstein, D.L.; Stubbe, J.
Purification of ribonucleotide reductase subunits Y1, Y2, Y3, and Y4 from yeast: Y4 plays a key role in diiron cluster assembly
Proc. Natl. Acad. Sci. USA
96
12339-12344
1999
Saccharomyces cerevisiae
Rova, U.; Adrait, A.; Potsch, S.; Graslund, A.; Thelander, L.
Evidence by mutagenesis that Tyr370 of the mouse ribonucleotide reductase R2 protein is the connecting link in the intersubunit radical transfer pathway
J. Biol. Chem.
274
23746-23751
1999
Mus musculus
Roshick, C.; Iliffe-Lee, E.R.; McClarty, G.
Cloning and characterization of ribonucleotide reductase from chlamydia trachomatis
J. Biol. Chem.
275
38111-38119
2000
Chlamydia trachomatis
Reichard, P.; Eliasson, R.; Ingemarson, R.; Thelander, L.
Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase
J. Biol. Chem.
275
33021-33026
2000
Mus musculus
Smalley, D.; Rocha, E.R.; Smith, C.J.
Aerobic-type ribonucleotide reductase in the anaerobe Bacteroides fragilis
J. Bacteriol.
184
895-903
2002
Bacteroides fragilis
Yun, D.; Krebs, C.; Gupta, G.P.; Iwig, D.F.; Huynh, B.H.; Bollinger, J.M., Jr.
Facile electron transfer during formation of cluster x and kinetic competence of x for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse
Biochemistry
41
981-990
2002
Mus musculus
Kashlan, O.B.; Scott, C.P.; Lear, J.D.; Cooperman, B.S.
A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit
Biochemistry
41
462-474
2002
Mus musculus
Cooperman, B.S.; Kashlan, O.B.
A comprehensive model for the allosteric regulation of class Ia ribonucleotide reductases
Adv. Enzyme Regul.
43
167-182
2003
Mus musculus
Schroeder, P.; Voevodskaya, N.; Klotz, L.O.; Brenneisen, P.; Graslund, A.; Sies, H.
Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin
Biochem. Biophys. Res. Commun.
326
614-617
2005
Homo sapiens, Mus musculus
Shao, J.; Zhou, B.; Zhu, L.; Bilio, A.J.; Su, L.; Yuan, Y.C.; Ren, S.; Lien, E.J.; Shih, J.; Yen, Y.
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay
Biochem. Pharmacol.
69
627-634
2005
Homo sapiens
He, J.; Roy, B.; Perigaud, C.; Kashlan, O.B.; Cooperman, B.S.
The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase
FEBS J.
272
1236-1242
2005
Mus musculus
Kolberg, M.; Logan, D.T.; Bleifuss, G.; Potsch, S.; Sjoberg, B.M.; Graslund, A.; Lubitz, W.; Lassmann, G.; Lendzian, F.
A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined X-ray diffraction and EPR/ENDOR studies
J. Biol. Chem.
280
11233-11246
2005
Escherichia coli (P69924), Escherichia coli
Birgander, P.L.; Bug, S.; Kasrayan, A.; Dahlroth, S.L.; Westman, M.; Gordon, E.; Sjoberg, B.M.
Nucleotide-dependent formation of catalytically competent dimers from engineered monomeric ribonucleotide reductase protein R1
J. Biol. Chem.
280
14997-15003
2005
Escherichia coli
Bracchi-Ricard, V.; Moe, D.; Chakrabarti, D.
Two Plasmodium falciparum ribonucleotide reductase small subunits, PfR2 and PfR4, interact with each other and are components of the in vivo enzyme complex
J. Mol. Biol.
347
749-758
2005
Plasmodium falciparum
Larsson, K.M.; Jordan, A.; Eliasson, R.; Reichard, P.; Logan, D.T.; Nordlund, P.
Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase
Nat. Struct. Mol. Biol.
11
1142-1149
2004
Thermotoga maritima (O33839)
Yao, R.; Zhang, Z.; An, X.; Bucci, B.; Perlstein, D.L.; Stubbe, J.; Huang, M.
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways
Proc. Natl. Acad. Sci. USA
100
6628-6633
2003
Saccharomyces cerevisiae
Lang, P.; Gerez, C.; Tritsch, D.; Fontecave, M.; Biellmann, J.F.; Burger, A.
Synthesis of 8-vinyladenosine 5'-di- and 5'-triphosphate: evaluation of the diphosphate compound on ribonucleotide reductase
Tetrahedron
59
7315-7322
2003
Escherichia coli
-
Cooperman, B.S.; Gao, Y.; Tan, C.; Kashlan, O.B.; Kaur, J.
Peptide inhibitors of mammalian ribonucleotide reductase
Adv. Enzyme Regul.
45
112-125
2005
Mus musculus
Qiu, W.; Zhou, B.; Darwish, D.; Shao, J.; Yen, Y.
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits
Biochem. Biophys. Res. Commun.
340
428-434
2006
Homo sapiens (Q7LG56)
Perlstein, D.L.; Ge, J.; Ortigosa, A.D.; Robblee, J.H.; Zhang, Z.; Huang, M.; Stubbe, J.
The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo
Biochemistry
44
15366-15377
2005
Saccharomyces cerevisiae
Ortigosa, A.D.; Hristova, D.; Perlstein, D.L.; Zhang, Z.; Huang, M.; Stubbe, J.
Determination of the in vivo stoichiometry of tyrosyl radical per betabeta in Saccharomyces cerevisiae ribonucleotide reductase
Biochemistry
45
12282-12294
2006
Saccharomyces cerevisiae
Saleh, L.; Bollinger, J.M.
Cation mediation of radical transfer between Trp48 and Tyr356 during O2 activation by protein R2 of Escherichia coli ribonucleotide reductase: relevance to R1-R2 radical transfer in nucleotide reduction?
Biochemistry
45
8823-8830
2006
Escherichia coli
Fuertes, M.J.; Kaur, J.; Deb, P.; Cooperman, B.S.; Smith, A.B.
Design, synthesis, and evaluation of octahydropyranopyrrole-based inhibitors of mammalian ribonucleotide reductase
Bioorg. Med. Chem. Lett.
15
5146-5149
2005
Mus musculus
Cerqueira, N.M.; Fernandes, P.A.; Eriksson, L.A.; Ramos, M.J.
Dehydration of ribonucleotides catalyzed by ribonucleotide reductase: the role of the enzyme
Biophys. J.
90
2109-2119
2006
Escherichia coli
Gautam, A.; Bepler, G.
Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase
Cancer Res.
66
6497-6502
2006
Mus musculus, Homo sapiens (P23921)
Pierce, B.S.; Hendrich, M.P.
Local and global effects of metal binding within the small subunit of ribonucleotide reductase
J. Am. Chem. Soc.
127
3613-3623
2005
Escherichia coli
Seyedsayamdost, M.R.; Stubbe, J.
Site-specific replacement of Y356 with 3,4-dihydroxyphenylalanine in the beta2 subunit of E. coli ribonucleotide reductase
J. Am. Chem. Soc.
128
2522-2523
2006
Escherichia coli
Torrents, E.; Westman, M.; Sahlin, M.; Sjoeberg, B.M.
Ribonucleotide reductase modularity: Atypical duplication of the ATP-cone domain in Pseudomonas aeruginosa
J. Biol. Chem.
281
25287-25296
2006
Pseudomonas aeruginosa
Narvaez, A.J.; Voevodskaya, N.; Thelander, L.; Graeslund, A.
The involvement of Arg265 of mouse ribonucleotide reductase R2 protein in proton transfer and catalysis
J. Biol. Chem.
281
26022-26028
2006
Mus musculus
Rofougaran, R.; Vodnala, M.; Hofer, A.
Enzymatically active mammalian ribonucleotide reductase exists primarily as an alpha6beta2 octamer
J. Biol. Chem.
281
27705-27711
2006
Mus musculus
Nordlund, P.; Eklund, H.
Structure and function of the Escherichia coli ribonucleotide reductase protein R2
J. Mol. Biol.
232
123-164
1993
Escherichia coli
Xu, H.; Faber, C.; Uchiki, T.; Fairman, J.W.; Racca, J.; Dealwis, C.
Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation
Proc. Natl. Acad. Sci. USA
103
4022-4027
2006
Saccharomyces cerevisiae (P21524)
Xu, H.; Faber, C.; Uchiki, T.; Racca, J.; Dealwis, C.
Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly
Proc. Natl. Acad. Sci. USA
103
4028-4033
2006
Saccharomyces cerevisiae (P21524)
Voevodskaya, N.; Narvaez, A.J.; Domkin, V.; Torrents, E.; Thelander, L.; Graeslund, A.
Chlamydial ribonucleotide reductase: tyrosyl radical function in catalysis replaced by the FeIII-FeIV cluster
Proc. Natl. Acad. Sci. USA
103
9850-9854
2006
Chlamydia trachomatis
Zhang, Z.; Yang, K.; Chen, C.C.; Feser, J.; Huang, M.
Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1
Proc. Natl. Acad. Sci. USA
104
2217-2222
2007
Saccharomyces cerevisiae, Escherichia coli
Friedrich, N.C.; Torrents, E.; Gibb, E.A.; Sahlin, M.; Sjoeberg, B.M.; Edgell, D.R.
Insertion of a homing endonuclease creates a genes-in-pieces ribonucleotide reductase that retains function
Proc. Natl. Acad. Sci. USA
104
6176-6181
2007
Cinqassovirus aeh1
Cerqueira, N.M.; Fernandes, P.A.; Ramos, M.J.
Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agents
Recent Pat. Anticancer Drug Discov.
2
11-29
2007
Escherichia coli
Avolio, T.M.; Lee, Y.; Feng, N.; Xiong, K.; Jin, H.; Wang, M.; Vassilakos, A.; Wright, J.; Young, A.
RNA interference targeting the R2 subunit of ribonucleotide reductase inhibits growth of tumor cells in vitro and in vivo
Anticancer Drugs
18
377-388
2007
Homo sapiens
Sigmond, J.; Kamphuis, J.A.; Laan, A.C.; Hoebe, E.K.; Bergman, A.M.; Peters, G.J.
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent
Biochem. Pharmacol.
73
1548-1557
2007
Homo sapiens
Jiang, W.; Xie, J.; N?rgaard, H.; Bollinger, J.M.; Krebs, C.
Rapid and quantitative activation of Chlamydia trachomatis ribonucleotide reductase by hydrogen peroxide
Biochemistry
47
4477-4483
2008
Chlamydia trachomatis
Jiang, W.; Saleh, L.; Barr, E.W.; Xie, J.; Gardner, M.M.; Krebs, C.; Bollinger, J.M.
Branched activation- and catalysis-specific pathways for electron relay to the manganese/iron cofactor in ribonucleotide reductase from Chlamydia trachomatis
Biochemistry
47
8477-8484
2008
Chlamydia trachomatis
Heidel, J.D.; Liu, J.Y.; Yen, Y.; Zhou, B.; Heale, B.S.; Rossi, J.J.; Bartlett, D.W.; Davis, M.E.
Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo
Clin. Cancer Res.
13
2207-2215
2007
Mus musculus
Voevodskaya, N.; Lendzian, F.; Ehrenberg, A.; Graeslund, A.
High catalytic activity achieved with a mixed manganese-iron site in protein R2 of Chlamydia ribonucleotide reductase
FEBS Lett.
581
3351-3355
2007
Chlamydia trachomatis
Odenike, O.M.; Larson, R.A.; Gajria, D.; Dolan, M.E.; Delaney, S.M.; Karrison, T.G.; Ratain, M.J.; Stock, W.
Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia
Invest. New Drugs
26
233-239
2008
Homo sapiens
Reece, S.Y.; Seyedsayamdost, M.R.; Stubbe, J.; Nocera, D.G.
Photoactive peptides for light-initiated tyrosyl radical generation and transport into ribonucleotide reductase
J. Am. Chem. Soc.
129
8500-8509
2007
Escherichia coli
Sen, G.; Mukhopadhyay, S.; Ray, M.; Biswas, T.
Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity
J. Antimicrob. Chemother.
61
1066-1075
2008
Leishmania donovani, Leishmania donovani MHOM/IN/1983/AG83
Kowol, C.R.; Berger, R.; Eichinger, R.; Roller, A.; Jakupec, M.A.; Schmidt, P.P.; Arion, V.B.; Keppler, B.K.
Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase
J. Med. Chem.
50
1254-1265
2007
Homo sapiens, Mus musculus
Cappellacci, L.; Franchetti, P.; Vita, P.; Petrelli, R.; Lavecchia, A.; Jayaram, H.N.; Saiko, P.; Graser, G.; Szekeres, T.; Grifantini, M.
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3-C-methyladenosine derivatives
J. Med. Chem.
51
4260-4269
2008
Homo sapiens
Xu, H.; Fairman, J.W.; Wijerathna, S.R.; Kreischer, N.R.; LaMacchia, J.; Helmbrecht, E.; Cooperman, B.S.; Dealwis, C.
The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore
J. Med. Chem.
51
4653-4659
2008
Saccharomyces cerevisiae (P21524), Saccharomyces cerevisiae
Nurbo, J.; Roos, A.K.; Muthas, D.; Wahlstroem, E.; Ericsson, D.J.; Lundstedt, T.; Unge, T.; Karlen, A.
Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase
J. Pept. Sci.
13
822-832
2007
Mycobacterium tuberculosis
Karp, J.E.; Giles, F.J.; Gojo, I.; Morris, L.; Greer, J.; Johnson, B.; Thein, M.; Sznol, M.; Low, J.
A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloprol
Leuk. Res.
32
71-77
2008
Homo sapiens
Ogata, H.; Stolle, P.; Stehr, M.; Auling, G.; Lubitz, W.
Crystallization and preliminary X-ray analysis of the small subunit (R2F) of native ribonucleotide reductase from Corynebacterium ammoniagenes
Acta Crystallogr. Sect. F
65
878-880
2009
Corynebacterium ammoniagenes
Zhu, L.; Zhou, B.; Chen, X.; Jiang, H.; Shao, J.; Yen, Y.
Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase
Biochem. Pharmacol.
78
1178-1185
2009
Homo sapiens
Tomter, A.B.; Bell, C.B.; Rohr, A.K.; Andersson, K.K.; Solomon, E.I.
Circular dichroism and magnetic circular dichroism studies of the biferrous site of the class Ib ribonucleotide reductase from Bacillus cereus: comparison to the class Ia enzymes
Biochemistry
47
11300-11309
2008
Bacillus cereus
Jiang, W.; Yun, D.; Saleh, L.; Bollinger, J.M.; Krebs, C.
Formation and function of the manganese(IV)/iron(III) cofactor in Chlamydia trachomatis ribonucleotide reductase
Biochemistry
47
13736-13744
2008
Chlamydia trachomatis (O84835), Chlamydia trachomatis, Escherichia coli (P69924)
Smith, P.; Zhou, B.; Ho, N.; Yuan, Y.C.; Su, L.; Tsai, S.C.; Yen, Y.
2.6 a X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase
Biochemistry
48
11134-11141
2009
Homo sapiens
Krishnan, K.; Prathiba, K.; Jayaprakash, V.; Basu, A.; Mishra, N.; Zhou, B.; Hu, S.; Yen, Y.
Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones
Bioorg. Med. Chem. Lett.
18
6248-6250
2008
Homo sapiens
Abbouni, B.; Oehlmann, W.; Stolle, P.; Pierik, A.J.; Auling, G.
Electron paramagnetic resonance (EPR) spectroscopy of the stable-free radical in the native metallo-cofactor of the manganese-ribonucleotide reductase (Mn-RNR) of Corynebacterium glutamicum
Free Radic. Res.
43
943-950
2009
Corynebacterium glutamicum, Corynebacterium glutamicum R163
Jensen, K.P.; Bell, C.B.; Clay, M.D.; Solomon, E.I.
Peroxo-type intermediates in class I ribonucleotide reductase and related binuclear non-heme iron enzymes
J. Am. Chem. Soc.
131
12155-12171
2009
Escherichia coli (P69924)
Offenbacher, A.R.; Vassiliev, I.R.; Seyedsayamdost, M.R.; Stubbe, J.; Barry, B.A.
Redox-linked structural changes in ribonucleotide reductase
J. Am. Chem. Soc.
131
7496-7497
2009
Escherichia coli
Voevodskaya, N.; Lendzian, F.; Sanganas, O.; Grundmeier, A.; Graeslund, A.; Haumann, M.
Redox intermediates of the Mn-Fe Site in subunit R2 of Chlamydia trachomatis ribonucleotide reductase: an X-ray absorption and EPR study
J. Biol. Chem.
284
4555-4566
2009
Chlamydia trachomatis
Yoo, S.C.; Cho, S.H.; Sugimoto, H.; Li, J.; Kusumi, K.; Koh, H.J.; Iba, K.; Paek, N.C.
Rice virescent3 and stripe1 encoding the large and small subunits of ribonucleotide reductase are required for chloroplast biogenesis during early leaf development
Plant Physiol.
150
388-401
2009
Oryza sativa (Q5VRJ6), Oryza sativa (Q6K848)
Roa, H.; Lang, J.; Culligan, K.M.; Keller, M.; Holec, S.; Cognat, V.; Montane, M.H.; Houlne, G.; Chaboute, M.E.
Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis
Plant Physiol.
151
461-471
2009
Arabidopsis thaliana (P0DKH2), Arabidopsis thaliana (P50651), Arabidopsis thaliana (Q9LSD0)
Gurmu, D.; Dahlroth, S.L.; Haas, J.; Nordlund, P.; Erlandsen, H.
Expression, purification, crystallization and preliminary X-ray analysis of ORF60, the small subunit (R2) of ribonucleotide reductase from Kaposis sarcoma-associated herpesvirus (KSHV)
Acta Crystallogr. Sect. F
66
734-737
2010
Human gammaherpesvirus 8
Cotruvo, J.A.; Stubbe, J.
An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase
Biochemistry
49
1297-1309
2010
Escherichia coli
Jiang, W.; Xie, J.; Varano, P.T.; Krebs, C.; Bollinger, J.M.
Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer
Biochemistry
49
5340-5349
2010
Chlamydia trachomatis
Seyedsayamdost, M.R.; Yee, C.S.; Stubbe, J.
Use of 2,3,5-F(3)Y-beta2 and 3-NH(2)Y-alpha2 to study proton-coupled electron transfer in Escherichia coli ribonucleotide reductase
Biochemistry
50
1403-1411
2011
Escherichia coli
Cotruvo, J.A.; Stubbe, J.
Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo
Biochemistry
50
1672-1681
2011
Escherichia coli, Escherichia coli GR536
Zhang, Y.; Stubbe, J.
Bacillus subtilis class Ib ribonucleotide reductase is a dimanganese(III)-tyrosyl radical enzyme
Biochemistry
50
5615-5623
2011
Bacillus subtilis, Bacillus subtilis JH624
Sanchez-Romero, M.A.; Molina, F.; Jimenez-Sanchez, A.
Correlation between ribonucleoside-diphosphate reductase and three replication proteins in Escherichia coli
BMC Mol. Biol.
11
11
2010
Escherichia coli
Holmgren, A.; Sengupta, R.
The use of thiols by ribonucleotide reductase
Free Radic. Biol. Med.
49
1617-1628
2010
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Lactobacillus leichmannii, Mus musculus
Han, W.G.; Noodleman, L.
DFT calculations for intermediate and active states of the diiron center with a tryptophan or tyrosine radical in Escherichia coli ribonucleotide reductase
Inorg. Chem.
50
2302-2320
2011
Escherichia coli
Sanchez-Romero, M.A.; Molina, F.; Jimenez-Sanchez, A.
Organization of ribonucleoside-diphosphate reductase during multifork chromosome replication in Escherichia coli
Microbiology
157
2220-2225
2011
Escherichia coli, Escherichia coli K-12 CM735
Logan, D.
Closing the circle on ribonucleotide reductases
Nat. Struct. Mol. Biol.
18
251-253
2011
Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium
Fairman, J.W.; Wijerathna, S.R.; Ahmad, M.F.; Xu, H.; Nakano, R.; Jha, S.; Prendergast, J.; Welin, R.M.; Flodin, S.; Roos, A.; Nordlund, P.; Li, Z.; Walz, T.; Dealwis, C.G.
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
Nat. Struct. Mol. Biol.
18
316-322
2011
Homo sapiens
Panosa, A.; Roca, I.; Gibert, I.
Ribonucleotide reductases of Salmonella typhimurium: transcriptional regulation and differential role in pathogenesis
PLoS ONE
5
e11328
2010
Salmonella enterica subsp. enterica serovar Typhimurium
Aye, Y.; Stubbe, J.
Clofarabine 5-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit
Proc. Natl. Acad. Sci. USA
108
9815-9820
2011
Homo sapiens
Boal, A.; Cotruvo Jr., J.; Stubbe, J.; Rosenzweig, A.
Structural basis for activation of class Ib ribonucleotide reductase
Science
329
1526-1530
2010
Escherichia coli (P37146)
Riera, J.; Robb, F.T.; Weiss, R.; Fontecave, M.
Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes?
Proc. Natl. Acad. Sci. USA
94
475-478
1997
Pyrococcus furiosus (E7FHX6)
Saiko, P.; Graser, G.; Giessrigl, B.; Lackner, A.; Grusch, M.; Krupitza, G.; Basu, A.; Sinha, B.; Jayaprakash, V.; Jaeger, W.; Fritzer-Szekeres, M.; Szekeres, T.
A novel N-hydroxy-N-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C)
Biochem. Pharmacol.
81
50-59
2011
Homo sapiens
Parker, M.J.; Zhu, X.; Stubbe, J.
Bacillus subtilis class Ib ribonucleotide reductase: high activity and dynamic subunit interactions
Biochemistry
53
766-776
2014
Bacillus subtilis, Bacillus subtilis JH624
Kan, S.C.; Yu, L.K.; Chen, J.H.; Hu, H.Y.; Hsu, W.H.
Mutational analysis of splicing activities of ribonucleotide reductase alpha subunit protein from lytic bacteriophage P1201
Curr. Microbiol.
62
1282-1286
2011
Corynebacterium phage P1201
Crona, M.; Torrents, E.; Rohr, A.K.; Hofer, A.; Furrer, E.; Tomter, A.B.; Andersson, K.K.; Sahlin, M.; Sjoeberg, B.M.
NrdH-redoxin protein mediates high enzyme activity in manganese-reconstituted ribonucleotide reductase from Bacillus anthracis
J. Biol. Chem.
286
33053-33060
2011
Bacillus anthracis (Q81G56), Bacillus anthracis ATCC 14579 (Q81G56)
Chimploy, K.; Song, S.; Wheeler, L.J.; Mathews, C.K.
Ribonucleotide reductase association with mammalian liver mitochondria
J. Biol. Chem.
288
13145-13155
2013
Rattus norvegicus
Chen, X.; Xu, Z.; Zhang, L.; Liu, H.; Liu, X.; Lou, M.; Zhu, L.; Huang, B.; Yang, C.G.; Zhu, W.; Shao, J.
The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit m2
J. Biol. Chem.
289
909-920
2014
Homo sapiens (P31350)
Ahmad, M.F.; Kaushal, P.S.; Wan, Q.; Wijerathna, S.R.; An, X.; Huang, M.; Dealwis, C.G.
Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase
J. Mol. Biol.
419
315-329
2012
Saccharomyces cerevisiae (P21524)
Mazumder, A.; Tummler, K.; Bathe, M.; Samson, L.D.
Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage
Mol. Cell. Biol.
33
635-642
2013
Saccharomyces cerevisiae
Martin, J.E.; Imlay, J.A.
The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation
Mol. Microbiol.
80
319-334
2011
Escherichia coli (P39452)
Yu, Y.; Suryo Rahmanto, Y.; Hawkins, C.L.; Richardson, D.R.
The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity
Mol. Pharmacol.
79
921-931
2011
Homo sapiens
Ando, N.; Brignole, E.J.; Zimanyi, C.M.; Funk, M.A.; Yokoyama, K.; Asturias, F.J.; Stubbe, J.; Drennan, C.L.
Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase
Proc. Natl. Acad. Sci. USA
108
21046-21051
2011
Escherichia coli (P00452)
Pontarin, G.; Ferraro, P.; Bee, L.; Reichard, P.; Bianchi, V.
Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells
Proc. Natl. Acad. Sci. USA
109
13302-13307
2012
Homo sapiens (Q7LG56)
Lofstad, M.; Gudim, I.; Hammerstad, M.; R?hr, A.K.; Hersleth, H.P.
Activation of the class Ib ribonucleotide reductase by a flavodoxin reductase in Bacillus cereus
Biochemistry
55
4998-5001
2016
Bacillus cereus (Q81G55), Bacillus cereus ATCC 14579 (Q81G55)
Knappenberger, A.J.; Ahmad, M.F.; Viswanathan, R.; Dealwis, C.G.; Harris, M.E.
Nucleoside analogue triphosphates allosterically regulate human ribonucleotide reductase and identify chemical determinants that drive substrate specificity
Biochemistry
55
5884-5896
2016
Saccharomyces cerevisiae, Homo sapiens (P23921), Homo sapiens (P23921 and P31350), Homo sapiens
Petrelli, R.; Meli, M.; Vita, P.; Torquati, I.; Ferro, A.; Vodnala, M.; DAlessandro, N.; Tolomeo, M.; Del Bello, F.; Kusumanchi, P.; Franchetti, P.; Grifantini, M.; Jayaram, H.N.; Hofer, A.; Cappellacci, L.
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase synthesis and biological evaluation of valproic esters of 3-C-methyladenosine
Bioorg. Med. Chem. Lett.
24
5304-5309
2014
Homo sapiens (P23921)
Zimanyi, C.M.; Chen, P.Y.; Kang, G.; Funk, M.A.; Drennan, C.L.
Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli
eLife
5
e07141
2016
Escherichia coli (P00452 and P69924), Escherichia coli
Graser-Loescher, G.; Schoenhuber, A.; Ciglenec, C.; Eberl, S.; Krupitza, G.; Mader, R.M.; Jadav, S.S.; Jayaprakash, V.; Fritzer-Szekeres, M.; Szekeres, T.; Saiko, P.
Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine
Food Chem. Toxicol.
108
53-62
2017
Homo sapiens (P23921)
Alnajar, S.; Khadka, B.; Gupta, R.
Ribonucleotide reductases from bifidobacteria contain multiple conserved indels distinguishing them from all other organisms In silico analysis of the possible role of a 43 aa bifidobacteria-specific insert in the class III RNR homolog
Front. Microbiol.
8
1409
2017
Bifidobacterium longum subsp. Longum, Bifidobacterium longum subsp. Longum ATCC 15707
Lee, B.; Ha, S.Y.; Song, D.H.; Lee, H.W.; Cho, S.Y.; Park, C.K.
High expression of ribonucleotide reductase subunit M2 correlates with poor prognosis of hepatocellular carcinoma
Gut and liver
8
662-668
2014
Homo sapiens (P31350)
Olshansky, L.; Pizano, A.A.; Wei, Y.; Stubbe, J.; Nocera, D.G.
Kinetics of hydrogen atom abstraction from substrate by an active site thiyl radical in ribonucleotide reductase
J. Am. Chem. Soc.
136
16210-16216
2014
Escherichia coli
Makhlynets, O.; Boal, A.; Rhodes, D.; Kitten, T.; Rosenzweig, A.; Stubbe, J.
Streptococcus sanguinis class Ib ribonucleotide reductase High activity with both iron and manganese cofactors and structural insights
J. Biol. Chem.
289
6259-6272
2014
Streptococcus sanguinis (A3CLZ6 AND A3CLZ4), Streptococcus sanguinis SK36 (A3CLZ6 AND A3CLZ4)
Jonna, V.R.; Crona, M.; Rofougaran, R.; Lundin, D.; Johansson, S.; Braennstroem, K.; Sjoeberg, B.M.; Hofer, A.
Diversity in overall activity regulation of ribonucleotide reductase
J. Biol. Chem.
290
17339-17348
2015
Pseudomonas aeruginosa
Hammerstad, M.; Rohr, A.K.; Andersen, N.H.; Graeslund, A.; Hoegbom, M.; Andersson, K.K.
The class Ib ribonucleotide reductase from Mycobacterium tuberculosis has two active R2F subunits
J. Biol. Inorg. Chem.
19
893-902
2014
Mycobacterium tuberculosis (P9WH75 and P9WH73 and P9WH71)
Zhu, M.; Dai, X.; Guo, W.; Ge, Z.; Yang, M.; Wang, H.; Wang, Y.P.
Manipulating the bacterial cell cycle and cell size by titrating the expression of ribonucleotide reductase
mBio
8
e01741-17
2017
Escherichia coli (P00452 and P69924)
Foskolou, I.P.; Jorgensen, C.; Leszczynska, K.B.; Olcina, M.M.; Tarhonskaya, H.; Haisma, B.; DAngiolella, V.; Myers, W.K.; Domene, C.; Flashman, E.; Hammond, E.M.
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
Mol. Cell
66
206-220.e9
2017
Homo sapiens (Q7LG56)
Arnaoutov, A.; Dasso, M.
Enzyme regulation. IRBIT is a novel regulator of ribonucleotide reductase in higher eukaryotes
Science
345
1512-1515
2014
Homo sapiens (P23921)
Johansson, R.; Jonna, V.R.; Kumar, R.; Nayeri, N.; Lundin, D.; Sjoeberg, B.M.; Hofer, A.; Logan, D.T.
Structural mechanism of allosteric activity regulation in a ribonucleotide reductase with double ATP cones
Structure
24
906-917
2016
Pseudomonas aeruginosa (Q9I4I1), Pseudomonas aeruginosa
html completed
