Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
xanthine + H2O + O2
urate + H2O2
allopurinol + H2O + O2
oxypurinol + H2O2
-
allopurinol is a substrate and a competitive inhibitor for xanthine oxidase, it binds irreversibly at the active site reducing molybdenum VI to IV
-
-
?
carboxylic aldehyde + H2O + O2
carboxylic acid + H2O2
-
enzyme is implicated in the control of various redox reactions in the cell, in milk: assures absorption of iron from the gut, coupling antibacterial effect via the lactoperoxidase system
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
pteridine + H2O + O2
?
-
-
-
-
?
purine + H2O + O2
?
-
-
-
-
?
xanthine + H2O + O2
urate + H2O2
xanthine + H2O + O2
uric acid + H2O2
xanthine + O2 + H2O
urate + H2O2
additional information
?
-
xanthine + H2O + O2
urate + H2O2
-
-
-
?
xanthine + H2O + O2
urate + H2O2
the enzyme is involved in regulation of reactive oxygen species in the functional response of veins and arteries to angiotensin II, norepinephrine, and acetylcholine
-
-
?
xanthine + H2O + O2
urate + H2O2
catalytically relevant binding mode of the substrate xanthine, overview
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
xanthine + H2O + O2
urate + H2O2
-
-
-
-
?
xanthine + H2O + O2
urate + H2O2
-
xanthine oxidoreductase, XOR, can exist in a dehydrogenase form, XD, and an oxidase form, XO. Part of total XOR activity in peroxisomes is XO activity. The major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of O2 radicals, but rather the production of uric acid which can act as a potent antioxidant
-
-
?
xanthine + H2O + O2
urate + H2O2
-
old animals show higher enzyme expression and activity than young rats which promotes a worse prognosis for patients with chronic heart failure due to the increased contents of risk factor urate, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
production of superoxide radicals
-
-
?
xanthine + H2O + O2
urate + H2O2
-
production of superoxide radicals can be induced by gama-irradiation and contributes to oxidative stress and endothelial nitroredox imbalance with resultant endothelial dysfunction and altered vascular mechanics, mechanism and regulation, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
urate is involved in development of endothelial dysfunction, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
xanthine oxidase inhibition by febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in hyperuricaemia, experimentally-induced by inhibition of uricase with oxonic acid, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
production of superoxide radicals, mechanism of stepwise enzyme reduction during catalysis, overview
-
-
?
xanthine + H2O + O2
uric acid + H2O2
-
electron acceptor O2
-
?
xanthine + H2O + O2
uric acid + H2O2
-
electron acceptor O2
-
?
xanthine + H2O + O2
uric acid + H2O2
-
electron acceptor O2
-
?
xanthine + H2O + O2
uric acid + H2O2
-
electron acceptor O2
-
?
xanthine + H2O + O2
uric acid + H2O2
-
electron acceptor O2
-
?
xanthine + H2O + O2
uric acid + H2O2
-
electron acceptor O2
-
?
xanthine + O2 + H2O
urate + H2O2
-
-
-
-
?
xanthine + O2 + H2O
urate + H2O2
-
binding modes of the substrate xanthine and mechanism of its hydroxylation, overview
-
-
?
additional information
?
-
purified recombinant wild-type and DELTAC mutant enzymes both exhibit mostly xanthine oxidase activity
-
-
?
additional information
?
-
-
xanthine oxidase is necessary during the physiological involution of tissues
-
-
?
additional information
?
-
-
enzyme inhibitors exert beneficial effect on endothelial dysfunction, mechanisms, overview, mechanism of action in cardiovascular disease, overview
-
-
?
additional information
?
-
-
xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in villar necrosis, reduced intestinal MPO levels, reduced circulating neutrophil priming and reduction in pulmonary damage, prevention of permeability changes in intestinal mucosa, reduction in length of necrotic small bowel by 60%, reduction in intestinal apoptosis and tissue MDA levels; reduction in plasma MDA levels and improvement in renal function, and improved small intestine anastomotic healing and animal survival, overview
-
-
?
additional information
?
-
-
xanthine oxidase-derived reactive oxygen species contribute to the development of D-galactosamine-induced liver injury in rats, overview
-
-
?
additional information
?
-
-
enzyme inhibition by orange juice and hesperetin participates in preventing oxidative stress by enhancing total antioxidant capacity and decreasing lipid peroxidation, overview
-
-
?
additional information
?
-
-
the oxidation of xanthine takes place at the molybdenum cofactor, and the electrons thus introduced are rapidly transferred to FAD via the Fe-SI and Fe-SII centers. Glu1261, located near the Mo-OH in the salicylate bound-form of XOR, initiates catalysis by deprotonating the Mo-OH group
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
hypoxanthine + 2 H2O + 2 O2
urate + 2 H2O2
-
-
-
?
xanthine + H2O + O2
urate + H2O2
carboxylic aldehyde + H2O + O2
carboxylic acid + H2O2
-
enzyme is implicated in the control of various redox reactions in the cell, in milk: assures absorption of iron from the gut, coupling antibacterial effect via the lactoperoxidase system
-
-
?
pteridine + H2O + O2
?
-
-
-
-
?
purine + H2O + O2
?
-
-
-
-
?
xanthine + H2O + O2
urate + H2O2
xanthine + O2 + H2O
urate + H2O2
-
-
-
-
?
additional information
?
-
xanthine + H2O + O2
urate + H2O2
-
-
-
?
xanthine + H2O + O2
urate + H2O2
the enzyme is involved in regulation of reactive oxygen species in the functional response of veins and arteries to angiotensin II, norepinephrine, and acetylcholine
-
-
?
xanthine + H2O + O2
urate + H2O2
catalytically relevant binding mode of the substrate xanthine, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
-
-
-
?
xanthine + H2O + O2
urate + H2O2
-
xanthine oxidoreductase, XOR, can exist in a dehydrogenase form, XD, and an oxidase form, XO. Part of total XOR activity in peroxisomes is XO activity. The major function of XOR activity in the cytoplasm of rat liver parenchymal cells and in sinusoidal cells is not the production of O2 radicals, but rather the production of uric acid which can act as a potent antioxidant
-
-
?
xanthine + H2O + O2
urate + H2O2
-
old animals show higher enzyme expression and activity than young rats which promotes a worse prognosis for patients with chronic heart failure due to the increased contents of risk factor urate, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
production of superoxide radicals
-
-
?
xanthine + H2O + O2
urate + H2O2
-
production of superoxide radicals can be induced by gama-irradiation and contributes to oxidative stress and endothelial nitroredox imbalance with resultant endothelial dysfunction and altered vascular mechanics, mechanism and regulation, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
the enzyme plays a role in the development of distant organ dysfunction after abdominal surgery, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
urate is involved in development of endothelial dysfunction, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
xanthine oxidase inhibition by febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in hyperuricaemia, experimentally-induced by inhibition of uricase with oxonic acid, overview
-
-
?
xanthine + H2O + O2
urate + H2O2
-
xanthine oxidase is an important source of reactive oxygen species that contributes to neurovascular dysfunction in experimental diabetes, overview
-
-
?
additional information
?
-
-
xanthine oxidase is necessary during the physiological involution of tissues
-
-
?
additional information
?
-
-
enzyme inhibitors exert beneficial effect on endothelial dysfunction, mechanisms, overview, mechanism of action in cardiovascular disease, overview
-
-
?
additional information
?
-
-
xanthine oxidase inhibition in small intestine ischemia-reperfusion injury leads to reduction in villar necrosis, reduced intestinal MPO levels, reduced circulating neutrophil priming and reduction in pulmonary damage, prevention of permeability changes in intestinal mucosa, reduction in length of necrotic small bowel by 60%, reduction in intestinal apoptosis and tissue MDA levels; reduction in plasma MDA levels and improvement in renal function, and improved small intestine anastomotic healing and animal survival, overview
-
-
?
additional information
?
-
-
xanthine oxidase-derived reactive oxygen species contribute to the development of D-galactosamine-induced liver injury in rats, overview
-
-
?
additional information
?
-
-
enzyme inhibition by orange juice and hesperetin participates in preventing oxidative stress by enhancing total antioxidant capacity and decreasing lipid peroxidation, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid
-
-
2-Amino-4-hydroxy-6-formylpterine
-
-
2-[(2,3-dimethylphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(2,4-dimethylphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(2-bromophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(2-chlorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(2-fluorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(3-bromophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(3-chlorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(3-fluorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(4-bromophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(4-chloro-3-methylphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(4-chlorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(4-fluorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
2-[(4-methoxyphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-[(2-methylphenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-[(2-nitrophenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-[(3-methylphenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-[(3-nitrophenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-[(4-methylphenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
7-methyl-2-[(4-nitrophenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
-
-
8-Hydroxyquinoline-7-sulfonic acid
-
-
asperuloside
-
from Paederia scandens extract
febuxostat
-
the inhibitor lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia
hesperetin
-
i.e. 3',5,7-trihydroxy-4'-methoxyflavanone, major flavanone component of orange juice, inhibits hepatic XOR activity and decreases serum uric acid levels, exhibits antioxidative and antihyperuricemic properties
lithospermic acid
-
isolated from roots of medicinal herb Salvia mitiorrhiza, the compound shows competitive enzyme inhibition activity and in vivo hypouricemic and anti-inflammatory effects in rats pretreated with uricase inhibitor potassium oxonate, overview
orange juice
-
inhibits hepatic XOR activity and decreases serum uric acid levels and exhibits antioxidative and antihyperuricemic properties
-
p-chloromercuribenzoate
-
-
paederoside
-
from Paederia scandens extract
pycnogenol
-
extract from french maritime pine bark, contains 75% (w/w) procyanidins formed by catechin and epicatechin but also taxifolin and phenolcarbonic acids and their glycosides, uncompetitive inhibitor, 0.01 mg/ml, 35% inhibition, 0.1 mg/ml, 80% inhibition, enzyme recovers activity upon dissociation of pycnogenol from enzyme
-
Pyridine
-
highly reduced activity of xanthine oxidase in the presence of pyridine, overview
scandoside
-
from Paederia scandens extract
Tetraethylthiuram disulfide
-
-
allopurinol
-
-
allopurinol
-
40% inhibition at 0.0285 g per kg body weight
allopurinol
-
i.e. 1, 5-dihydro-4H-pyrazolo [3, 4-d]pyrimidine-4-one, allopurinol is a substrate and a competitive inhibitor for xanthine oxidase, it binds irreversibly at the active site reducing molybdenum VI to IV, and it is used for treatment of hyperuricemia
allopurinol
-
treatment with the inhibitor improves nerve and vascular function in diabetic rats, sciatic nerve and superior cervical ganglion blood flow is halved by diabetes and allopurinol corrects this by approximately 63%, Ngamma-nitro-L-arginine acts as an antagonist, effects on diabetic and non-diabetic rats, overview
allopurinol
-
shows strong enzyme inhibition and hypouricemic effect
additional information
-
alcoholic extract of air-dried aerial parts of the plant Paederia scandens has inhibitory activity on the enzyme and in vivo antihypouricemic activity in hyperuricemic rats pretreated with potassium oxonate, overview, no inhibition by benzbromarone and potassium oxonate
-
additional information
-
synthesis and inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives, molecular modeling and docking studies, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.00176
2-[(2,4-dimethylphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000413
2-[(2-bromophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000183
2-[(2-chlorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00059
2-[(2-fluorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00256
2-[(3-bromophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00618
2-[(3-chlorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00198
2-[(3-fluorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000623
2-[(4-chloro-3-methylphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000449
2-[(4-chlorophenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000289
2-[(4-methoxyphenoxy)methyl]-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000555
7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000362
7-methyl-2-[(2-methylphenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00107
7-methyl-2-[(3-methylphenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00102
7-methyl-2-[(4-methylphenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.00203
7-methyl-2-[(4-nitrophenoxy)methyl]-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
0.000753
allopurinol
Rattus norvegicus
-
pH 7.5, temperature not specified in the publication
additional information
additional information
Rattus norvegicus
-
IC50 of lithopsermic acid is 0.0052 mg/ml
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Maia, L.; Mira, L.
Xanthine oxidase and aldehyde oxidase: A simple procedure for the simultaneous purification from rat liver
Arch. Biochem. Biophys.
400
48-53
2002
Rattus norvegicus
brenda
Waud, W.R.; Rajagopalan, K.V.
Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase
Arch. Biochem. Biophys.
172
354-364
1976
Rattus norvegicus
brenda
Della Corte, E.; Stirpe, F.
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme
Biochem. J.
126
739-745
1972
Rattus norvegicus
brenda
Moini, H.; Guo, Q.; Packer, L.
Enzyme inhibiton and protein-binding action of the procyanidin-rich french maritime pine bark extract, pycnogenol: effect on xanthine oxidase
J. Agric. Food Chem.
48
5630-5639
2000
Rattus norvegicus
brenda
Zikakis, J.P.; Dressel, M.A.; Silver, M.R.
Bovine, caprine, and human milk xanthine oxidases: isolation, purification, and characterization
Instrum. Anal. Foods, Recent Prog. (Proc. Symp. Int. Flavor Conf. , 3rd Ed. , Charalambous, G. , Inglett, G. , eds. )
2
243-303
1983
Bos taurus, Canis lupus familiaris, Capra hircus, Cavia porcellus, Oryctolagus cuniculus, Equus asinus, Equus caballus, Erythrocebus patas, Felis catus, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Erythrocebus patas Patas monkey
-
brenda
Stirpe, F.; Della Corte, E.
The regulation of rat liver xanthine oxidase: conversion of type D (dehydrogenase) into type O (oxidase) by a thermolabile factor, and reversibility by dithioerythritol
Biochim. Biophys. Acta
212
195-197
1970
Bos taurus, Rattus norvegicus
brenda
De Renzo, E.C.
Chemistry and biochemistry of xanthine oxidase
Adv. Enzymol. Relat. Subj. Biochem.
17
293-328
1956
Bos taurus, Gallus gallus, Rattus norvegicus
brenda
Frederiks, W.M.; Vreeling-Sindelarova, H.
Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells
Acta Histochem.
104
29-37
2002
Rattus norvegicus
brenda
Rus, D.A.; Sastre, J.; Vina, J.; Pallardo, F.V.
Induction of mitochondrial xanthine oxidase activity during apoptosis in the rat mammary gland
Front. Biosci.
12
1184-1189
2007
Rattus norvegicus
brenda
Asai, R.; Nishino, T.; Matsumura, T.; Okamoto, K.; Igarashi, K.; Pai, E.F.; Nishino, T.
Two mutations convert mammalian xanthine oxidoreductase to highly superoxide-productive xanthine oxidase
J. Biochem.
141
525-534
2007
Rattus norvegicus (P22985)
brenda
Szasz, T.; Thompson, J.M.; Watts, S.W.
A comparison of reactive oxygen species metabolism in the rat aorta and vena cava: focus on xanthine oxidase
Am. J. Physiol. Heart Circ. Physiol.
295
H1341-H1350
2008
Rattus norvegicus (P22985)
brenda
George, J.; Struthers, A.D.
The role of urate and xanthine oxidase inhibitors in cardiovascular disease
Cardiovasc. Ther.
26
59-64
2008
Homo sapiens, Rattus norvegicus
brenda
Liu, X.; Chen, R.; Shang, Y.; Jiao, B.; Huang, C.
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats
Chem. Biol. Interact.
176
137-142
2008
Rattus norvegicus
brenda
Inkster, M.E.; Cotter, M.A.; Cameron, N.E.
Treatment with the xanthine oxidase inhibitor, allopurinol, improves nerve and vascular function in diabetic rats
Eur. J. Pharmacol.
561
63-71
2007
Rattus norvegicus
brenda
Aranda, R.; Domenech, E.; Rus, A.D.; Real, J.T.; Sastre, J.; Vina, J.; Pallardo, F.V.
Age-related increase in xanthine oxidase activity in human plasma and rat tissues
Free Radic. Res.
41
1195-1200
2007
Homo sapiens, Rattus norvegicus
brenda
Ohta, Y.; Matsura, T.; Kitagawa, A.; Tokunaga, K.; Yamada, K.
Xanthine oxidase-derived reactive oxygen species contribute to the development of D-galactosamine-induced liver injury in rats
Free Radic. Res.
41
135-144
2007
Rattus norvegicus
brenda
Devrim, E.; Avci, A.; Ergueder, I.B.; Karagenc, N.; Kuelah, B.; Durak, I.
Activities of xanthine oxidase and superoxide dismutase enzymes in rat intestinal tissues in sepsis
J. Trauma
64
733-735
2008
Rattus norvegicus
brenda
Sanchez-Lozada, L.G.; Tapia, E.; Soto, V.; Avila-Casado, C.; Franco, M.; Zhao, L.; Johnson, R.J.
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia
Nephrol. Dial. Transplant.
23
1179-1185
2008
Rattus norvegicus
brenda
Yan, H.; Ma, Y.; Liu, M.; Zhou, L.
The dual actions of Paederia scandens extract as a hypouricemic agent: xanthine oxidase inhibitory activity and uricosuric effect
Planta Med.
74
1345-1350
2008
Rattus norvegicus
brenda
Soucy, K.G.; Lim, H.K.; Benjo, A.; Santhanam, L.; Ryoo, S.; Shoukas, A.A.; Vazquez, M.E.; Berkowitz, D.E.
Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta
Radiat. Environ. Biophys.
46
179-186
2007
Rattus norvegicus
brenda
Mittal, A.; Phillips, A.R.; Loveday, B.; Windsor, J.A.
The potential role for xanthine oxidase inhibition in major intra-abdominal surgery
World J. Surg.
32
288-295
2008
Felis silvestris, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Nishino, T.; Okamoto, K.; Eger, B.T.; Pai, E.F.; Nishino, T.
Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase
FEBS J.
275
3278-3289
2008
Bos taurus, Rattus norvegicus
brenda
Haidari, F.; Ali Keshavarz, S.; Reza Rashidi, M.; Mohammad Shahi, M.
Orange juice and hesperetin supplementation to hyperuricemic rats alter oxidative stress markers and xanthine oxidoreductase activity
J. Clin. Biochem. Nutr.
45
285-291
2009
Rattus norvegicus
brenda
Sathisha, K.R.; Khanum, S.A.; Chandra, J.N.; Ayisha, F.; Balaji, S.; Marathe, G.K.; Gopal, S.; Rangappa, K.S.
Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives
Bioorg. Med. Chem.
19
211-220
2011
Bos taurus, Rattus norvegicus
brenda
Amini, K.; Sorouraddin, M.; Rashidi, M.
Activity and stability of rat liver xanthine oxidase in the presence of pyridine
Can. J. Chem.
89
1-7
2011
Rattus norvegicus
-
brenda
Okamoto, K.; Kawaguchi, Y.; Eger, B.; Pai, E.; Nishino, T.
Crystal structures of urate bound form of xanthine oxidoreductase: Substrate orientation and structure of the key reaction intermediate
J. Am. Chem. Soc.
132
17080-17083
2010
Bos taurus, Rattus norvegicus (P22985)
brenda
Gibbings, S.; Elkins, N.D.; Fitzgerald, H.; Tiao, J.; Weyman, M.E.; Shibao, G.; Fini, M.A.; Wright, R.M.
Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha
J. Biol. Chem.
286
961-975
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Nishino, T.; Okamoto, K.; Kawaguchi, Y.; Matsumura, T.; Eger, B.T.; Pai, E.F.; Nishino, T.
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
FEBS J.
282
3075-3090
2015
Rattus norvegicus (P22985)
brenda