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Disease on EC 1.16.1.8 - [methionine synthase] reductase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Polymorphisms in the methylene tetrahydrofolate reductase and methionine synthase reductase genes and their correlation with unexplained recurrent spontaneous abortion susceptibility.
[Association of methionine synthase reductase gene polymorphism with unexplained recurrent spontaneous abortion].
Abruptio Placentae
Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption.
Adenocarcinoma
Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.
Adenoma
Low folate status, and MTHFR 677C?>?T and MTR 2756A?>?G polymorphisms associated with colorectal cancer risk in Thais: a case-control study.
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
Anemia, Megaloblastic
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
Polymorphic background of methionine synthase reductase modulates the phenotype of a disease-causing mutation.
Arthritis, Rheumatoid
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
Atherosclerosis
[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries]
Azoospermia
Association between genetic polymorphisms in folate-related enzyme genes and infertile men with non-obstructive azoospermia.
Brain Neoplasms
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
Breast Neoplasms
Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women.
Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women.
Methionine synthase reductase A66G polymorphism is not associated with breast cancer susceptibility - a meta-analysis.
MTRR A66G polymorphism and breast cancer risk: a meta-analysis.
Carcinogenesis
Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies.
MTRR silencing inhibits growth and cisplatin resistance of ovarian carcinoma via inducing apoptosis and reducing autophagy.
Carcinoma
Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
Carcinoma in Situ
Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.
Carcinoma, Hepatocellular
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population.
Carcinoma, Squamous Cell
Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis.
Cardiovascular Diseases
[The role of homocysteine and methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase polymorphisms in the development of cardiovascular diseases and hypertension].
Cervical Intraepithelial Neoplasia
Polymorphisms in Genes Involved in Folate Metabolism Modify the Association of Dietary and Circulating Folate and Vitamin B-6 with Cervical Neoplasia.
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
Cleft Lip
Associations Between MTR A2756G, MTRR A66G, and TCN2 C776G Polymorphisms and Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate: A Meta-Analysis.
MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate.
Cleft Palate
Associations Between MTR A2756G, MTRR A66G, and TCN2 C776G Polymorphisms and Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate: A Meta-Analysis.
MTR, MTRR, and MTHFR Gene Polymorphisms and Susceptibility to Nonsyndromic Cleft Lip With or Without Cleft Palate.
Colonic Neoplasms
Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
Colorectal Neoplasms
Associations of the A66G Methionine Synthase Reductase Polymorphism in Colorectal Cancer: A Systematic Review and Meta-Analysis.
Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women.
Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer.
The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer.
Congenital Abnormalities
Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi.
[Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China].
Coronary Artery Disease
A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease.
Genetic polymorphisms predisposing to hyperhomocysteinemia in cardiac transplant patients.
Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease.
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease.
[Associations of polymorphisms of methionine synthase A2756G and methionine synthase reductase G66A with the risks of coronary artery disease: a meta-analysis].
Coronary Disease
Three Genetic Polymorphisms of Homocysteine-Metabolizing Enzymes and Risk of Coronary Heart Disease: A Meta-Analysis Based on 23 Case-Control Studies.
Diabetes Mellitus, Type 1
Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes.
Diabetes Mellitus, Type 2
Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes.
Down Syndrome
Abnormal folate metabolism in mothers with Down syndrome offspring: Review of the literature.
Detection of MTRR 66A-->G polymorphism using the real-time polymerase chain reaction machine LightCycler for determination of composition of allele after restriction cleavage.
Functional variant in methionine synthase reductase decreases the risk of Down syndrome in China.
Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.
Maternal folate polymorphisms and the etiology of human nondisjunction.
Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome.
MTRR and MTHFR polymorphism: link to Down syndrome?
No association between common polymorphisms in genes of folate and homocysteine metabolism and the risk of Down's syndrome among French mothers.
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China.
Reflections on the possible role of the methionine synthase reductase (MTRR) A66G polymorphism as a maternal risk factor for Down syndrome in Italy.
The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome.
The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.
[Folate gene polymorphism and the risk of Down syndrome pregnancies in young Chinese women]
Epilepsy
A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis.
Essential Hypertension
[Association of plasma homocysteine level and polymorphism of methione synthase reductase gene with essential hypertension in ethnic Uyghurs and Hans from Xinjiang].
Glioma
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
glutamate formimidoyltransferase deficiency
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Heart Defects, Congenital
A66G and C524T polymorphisms of methionine synthase reductase gene are linked to the development of acyanotic congenital heart diseases in Egyptian children.
A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population.
Association Between Methionine Synthase Reductase A66G Polymorphism and the Risk of Congenital Heart Defects: Evidence From Eight Case-Control Studies.
Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population.
Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.
The roles of MTRR and MTHFR gene polymorphisms in congenital heart diseases: a meta-analysis.
Homocystinuria
CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families.
cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression.
Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.
Polymorphic background of methionine synthase reductase modulates the phenotype of a disease-causing mutation.
[A Rare Inborn Error of Intracellular Processing of Cobalamine Presenting with Microcephalus and Megaloblastic Anemia: A Report of 3 Children.]
[A rare inborn error of intracellular processing of cobalamine presenting with microcephalus and megaloblastic anemia: a report of 3 children]
Hyperhomocysteinemia
Association Between Methionine Synthase Reductase A66G Polymorphism and the Risk of Congenital Heart Defects: Evidence From Eight Case-Control Studies.
Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients.
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
Polymorphisms in the CBS gene and homocysteine, folate and vitamin B12 levels: association with polymorphisms in the MTHFR and MTRR genes in Brazilian children.
Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children.
Hypertension
Effects of methionine synthase and methionine synthase reductase polymorphisms on hypertension susceptibility.
Investigation of homocysteine-pathway-related variants in essential hypertension.
The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia.
Infertility
Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males.
Infertility, Male
A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12.
Association between Methionine Synthase Reductase A66G Polymorphism and Male Infertility: A Meta-Analysis.
Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males.
Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility.
Leukemia
Influence Of Folate-Related Gene Polymorphisms On High-Dose Methotrexate-Related Toxicity And Prognosis In Turkish Children With Acute Lymphoblast?c Leukem?a.
Methionine synthase reductase A66G polymorphism and leukemia risk: evidence from published studies.
Lung Neoplasms
Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.
Polymorphisms of methionine synthase and methionine synthase reductase and risk of lung cancer: a case-control analysis.
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Lymphoma, Non-Hodgkin
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.
Malaria
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
Meningioma
5,10-Methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) gene polymorphisms and adult meningioma risk.
Association of methionine synthase rs1801394 and methionine synthase reductase rs1805087 polymorphisms with meningioma in adults: A meta-analysis.
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
methionine synthase deficiency
An infant with an extremely rare cobalamin disorder: Methionine synthase deficiency and importance of early diagnosis and treatment.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Migraine Disorders
Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.
Multiple Myeloma
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.
Neoplasms
Esophageal and gastric cardia cancer risk and folate- and vitamin B(12)-related polymorphisms in Linxian, China.
Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies.
Methionine Synthase Reductase-A66G and -C524T Single Nucleotide Polymorphisms and Prostate Cancer: A Case-Control Trial
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms as risk factors for hepatocellular carcinoma in a Korean population.
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
Polymorphisms in Genes Involved in Folate Metabolism Modify the Association of Dietary and Circulating Folate and Vitamin B-6 with Cervical Neoplasia.
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
The relationship between methionine synthase rs1805087 polymorphism and hematological cancers risk.
Neural Tube Defects
"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis"
Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association.
Association between MTR A2756G and MTRR A66G polymorphisms and maternal risk for neural tube defects: a meta-analysis.
Association of MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms with Neural Tube Defects in Tunisian Parents.
Detection of MTRR 66A-->G polymorphism using the real-time polymerase chain reaction machine LightCycler for determination of composition of allele after restriction cleavage.
Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India.
Structural insight into the effect of polymorphic variation on the functional dynamics of methionine synthase reductase: Implications in neural tube defects.
Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.
Obesity
Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?
Ovarian Neoplasms
[Biological effect of down-regulating of MTRR gene on cisplatin-resistant ovarian cancer SKOV3 cells in vitro and in vivo studies].
Pancreatic Neoplasms
Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk.
His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk.
Pre-Eclampsia
The polymorphisms of methionine synthase (MTR) and methionine synthase reductase (MTRR) genes in pathogenesis of preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults.
Pregnancy Complications
Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate Reductase (MTHFR), Methionine Synthase Reductase (MTRR) Reduced Pregnant Complications.
Prostatic Neoplasms
Methionine Synthase Reductase-A66G and -C524T Single Nucleotide Polymorphisms and Prostate Cancer: A Case-Control Trial
Small Cell Lung Carcinoma
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Spinal Dysraphism
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.
Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects.
Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida.
Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida.
The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida.
Squamous Cell Carcinoma of Head and Neck
One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.
Stomach Neoplasms
Genetic polymorphisms in folate-metabolizing genes associated with gastric cancer prognosis in northwest China subjects.
Stroke
Common mutations at the homocysteine metabolism pathway and pediatric stroke.
The role of B vitamins in stroke prevention.
Thrombosis
Polymorphisms in the methylenetetrahydrofolate reductase and methionine synthase reductase genes and homocysteine levels in Brazilian children.
Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians.
Thyroid Diseases
Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.
Urinary Bladder Neoplasms
Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population.
Uterine Cervical Neoplasms
The association between MTHFR polymorphism and cervical cancer.
The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
Vascular Diseases
Methionine synthase reductase (MTRR) A66G polymorphism is not related to plasma homocysteine concentration and the risk for vascular disease.
Methionine Synthase Reductase (MTRR) A66G polymorphism is not related with plasma homocysteine concentration and risk for vascular disease.
Venous Thrombosis
Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians.
Xeroderma Pigmentosum
Cytogenetic biomarkers and genetic polymorphisms.
[methionine synthase] reductase deficiency
CblE type of homocystinuria due to methionine synthase reductase deficiency: clinical and molecular studies and prenatal diagnosis in two families.
cblE type of homocystinuria due to methionine synthase reductase deficiency: functional correction by minigene expression.
CblE type of homocystinuria: mild clinical phenotype in two patients homozygous for a novel mutation in the MTRR gene.
Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias.
Methionine synthase reductase deficiency (CblE): A report of two patients and a novel mutation.
Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
[A Rare Inborn Error of Intracellular Processing of Cobalamine Presenting with Microcephalus and Megaloblastic Anemia: A Report of 3 Children.]
[A rare inborn error of intracellular processing of cobalamine presenting with microcephalus and megaloblastic anemia: a report of 3 children]