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Enzyme Nomenclature
Information on EC 1.14.99.49 - 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
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The expected taxonomic range for this enzyme is: Streptomyces carzinostaticus
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EC NUMBER 
COMMENTARY 
1.14.99.49
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RECOMMENDED NAME
GeneOntology No.
2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2 = 2,7-dihydroxy-5-methyl-1-naphthoate + oxidized acceptor + H2O
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
2-hydroxy-5-methyl-1-naphthoate,hydrogen-donor:oxygen oxidoreductase (7-hydroxylating)
A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
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-
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-
?
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
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the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
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-
?
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
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-
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?
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
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the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
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-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
-
the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
-
-
?
2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2
2,7-dihydroxy-5-methyl-1-naphthoate + acceptor + H2O
-
the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
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-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
heterologous expression of the gene together with ncsB and ncsB1 in Streptomyces lividans TK24
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.99.49)
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