Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 1.14.99.38 - cholesterol 25-monooxygenase and Organism(s) Homo sapiens and UniProt Accession P08684

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
abc-type xenobiotic transporter deficiency
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Arthritis
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Atherosclerosis
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome.
KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility.
Bacterial Infections
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Breast Neoplasms
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
cholesterol 25-monooxygenase deficiency
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Colitis
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function.
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.
Colorectal Neoplasms
Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.
Dermatitis, Contact
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Encephalomyelitis
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Encephalomyelitis, Autoimmune, Experimental
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Gastroenteritis
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Gastroenteritis, Transmissible, of Swine
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Hepatitis C
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Herpes Simplex
Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein.
Infections
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
A balanced game: chicken macrophage response to ALV-J infection.
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.
Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways.
Cholesterol 25-hydroxylase inhibits encephalomyocarditis virus replication through enzyme activity-dependent and independent mechanisms.
Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms.
Cholesterol 25-hydroxylase inhibits Senecavirus A replication by enzyme activity-dependent and independent mechanisms.
Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry.
Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol.
Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti.
Endogenous Retrovirus ev21 Dose Not Recombine with ALV-J and Induces the Expression of ISGs in the Host.
Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry.
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages.
Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques.
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities.
Porcine reproductive and respiratory syndrome virus E protein degrades porcine cholesterol 25-hydroxylase via the ubiquitin-proteasome pathway.
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol.
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Influenza, Human
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
Insulin Resistance
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Leukodystrophy, Globoid Cell
Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease.
Liver Neoplasms
Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression.
Malaria
Malaria infection alters the expression of hepatobiliary and placental drug transporters in pregnant mice.
Melanoma
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Extracellular vesicles in cancer progression.
Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene.
Multiple Sclerosis
Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Neoplasm Metastasis
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Extracellular vesicles in cancer progression.
Neoplasms
Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies.
Extracellular vesicles in cancer progression.
Helicobacter hepaticus-Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response.
IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages.
Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver.
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.
Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.
Neuromyelitis Optica
Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Non-alcoholic Fatty Liver Disease
Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease.
Obesity
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Obesity, Metabolically Benign
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Osteoarthritis
Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes.
The CH25H-CYP7B1-ROR? axis of cholesterol metabolism regulates osteoarthritis.
Paralysis
Functional coupling of ATP binding cassette transporter Abcb6 to Cytochrome P450 expression and activity in liver.
Porcine Reproductive and Respiratory Syndrome
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Pseudorabies
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.
Pulmonary Disease, Chronic Obstructive
25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-?B dependent pathway.
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
Rabies
Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Reoviridae Infections
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Reperfusion Injury
The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Rift Valley Fever
Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities.
Sarcoma, Experimental
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.
Vesicular Stomatitis
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
Viremia
Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish.
Virus Diseases
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination.
Antiviral activity of porcine interferon delta 8 against pesudorabies virus in vitro.
Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways.
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Interferons: Reprogramming the Metabolic Network against Viral Infection.
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol.
Zika Virus Infection
25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.
IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages.