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Information on EC 1.14.99.36 - beta-carotene 15,15'-monooxygenase and Organism(s) Rattus norvegicus and UniProt Accession Q91XT5

for references in articles please use BRENDA:EC1.14.99.36
deleted. Now classified as EC 1.13.11.63, beta-carotene 15,15'-dioxygenase
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Synonyms
beta-carotene 15,15'-dioxygenase, more
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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BCMO1 catalyzes the symmetric cleavage of carotenoids
metabolism
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carotenoids and apo-carotenoids are converted to retinal by beta-carotene 15,15'-dioxygenase, BCDO, by beta-carotene 15,15'-monooxygenase, BCMO, and by apo-carotenoid 15,15'-oxygenase, ACO, EC 1.14.99.41
physiological function
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
chronic alcohol intake significantly upregulates hepatic BCMO1 expression in rats, possibly mediated via PPAR-gamma
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all-trans-retinal suppresses liver, lung and testis bcmo1 expression, and 9-cis-retinal in lung and testis, in vitamin A-deficient rats
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BCM gene expression in the kidney of puromycin aminonucleoside-treated rats is increased
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BCM gene expression in the liver and intestines of puromycin aminonucleoside-treated rats is decreased
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intestinal BCM gene expresssion is increased in obese and dyslipedemic rats
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