Information on EC 1.14.99.36 - beta-carotene 15,15'-monooxygenase

New: Word Map on EC 1.14.99.36
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Search Reference ID:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.99.36
deleted. Now classified as EC 1.13.11.63, beta-carotene 15,15'-dioxygenase
RECOMMENDED NAME
GeneOntology No.
beta-carotene 15,15'-monooxygenase
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1016 - 1.52
beta-carotene
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
all-trans-retinal at 0.001 mM suppresses bcmo1 expression
-
all-trans-retinal does not affect liver bcmo1 expression
-
all-trans-retinal suppresses liver, lung and testis bcmo1 expression, and 9-cis-retinal in lung and testis, in vitamin A-deficient rats
-
BCM gene expression in the kidney of puromycin aminonucleoside-treated rats is increased
-
BCM gene expression in the liver and intestines of puromycin aminonucleoside-treated rats is decreased
-
Bcmo1 expression is induced during adipocyte differentiation
-
beta-carotene and all-trans-retinal at 10-100 nM induces bcmo1 expression
-
chronic alcohol intake significantly upregulates hepatic BCMO1 expression in rats, possibly mediated via PPAR-gamma
-
exposure to beta-carotene suppresses CMO1 expression at both mRNA and protein levels. beta-Carotene, but not all-trans retinoic acid, decreases CMO1 promoter activity in a time- and dosage-dependent manner. This beta-carotene-mediated inhibition of CMO1 expression results from decreased binding of peroxisome proliferator-activated receptor gamma and retinoid X receptor alpha in the CMO1 promoter
-
intestinal BCM gene expresssion is increased in obese and dyslipedemic rats
-
Isx, intestine specific homeobox, participates in the maintenance of vitamin A by regulating Bcmo1 expression in the intestine
-
severe vitamin A deficiency markedly decreases intestine-specific transcription factor intestine-specific homeobox expression accompanied by an increase in BCMO1 expression in duodenum and jejunum
-
Show AA Sequence (303 entries)
Please use the Sequence Search for a certain query.