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Enzyme Nomenclature
Information on EC 1.14.21.11 - (-)-pluviatolide synthase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.14.21.11
-
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RECOMMENDED NAME
GeneOntology No.
(-)-pluviatolide synthase
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(-)-matairesinol + NADPH + H+ + O2 = (-)-pluviatolide + NADP+ + 2 H2O
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
(-)-matairesinol,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)
The enzyme, characterized from the plants Sinopodophyllum hexandrum and Podophyllum peltatum, catalyses the formation of a methylenedioxy-bridge. It is involved in the biosynthesis of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
metabolism
the enzyme is involved in the podophyllotoxin biosynthesis, detailed pathway overview
metabolism
the enzyme is involved in the podophyllotoxin biosynthesis, detailed pathway overview
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
-
-
-
?
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
(-)-matairesinol is isolated from Forsythia intermedia
product identification and quantification by 1H, 13C, and 13C,1H heteronuclear single quantum coherence NMR spectroscopic analyses
-
?
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
-
-
-
?
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
(-)-matairesinol is isolated from Forsythia intermedia
product identification and quantification by 1H, 13C, and 13C,1H heteronuclear single quantum coherence NMR spectroscopic analyses
-
?
additional information
?
-
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
additional information
?
-
-
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
additional information
?
-
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
additional information
?
-
-
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
L7T720
-
-
-
?
(-)-matairesinol + NADPH + H+ + O2
(-)-pluviatolide + NADP+ + 2 H2O
L7T8H2
-
-
-
?
additional information
?
-
L7T720
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
additional information
?
-
-
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
additional information
?
-
L7T8H2
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
additional information
?
-
-
the enzyme is capable of converting (-)-matairesinol into (-)-pluviatolide by catalyzing methylenedioxy bridge formation and does not act on other possible substrates tested, i.e. (+)-pinoresinol, (-)-pinoresinol, (-)-arctigenin, (-)-alpha-conidendrin, (+)-piperitol, (-)-piperitol, and (+)-phillygenin
-
-
-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
steady-state Michaelis-Menten kinetics
-
additional information
additional information
-
steady-state Michaelis-Menten kinetics
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additional information
additional information
steady-state Michaelis-Menten kinetics
-
additional information
additional information
-
steady-state Michaelis-Menten kinetics
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
25
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene CYP719A23, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis
gene CYP719A24, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.21.11)
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