Information on EC 1.14.21.10 - fumitremorgin C synthase

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The expected taxonomic range for this enzyme is: Aspergillus fumigatus

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EC NUMBER
COMMENTARY hide
1.14.21.10
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RECOMMENDED NAME
GeneOntology No.
fumitremorgin C synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
tryprostatin A + NADPH + H+ + O2 = fumitremorgin C + NADP+ + 2 H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
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fumitremorgin C biosynthesis
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Staurosporine biosynthesis
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fumitremorgin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
tryprostatin A,NADPH:oxygen oxidoreductase
A heme-thiolate protein (P-450). The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
tryprostatin A + NADPH + H+ + O2
fumitremorgin C + NADP+ + 2 H2O
show the reaction diagram
tryprostatin B + NADPH + H+ + O2
demethoxyfumitremorgin C + NADP+ + 2 H2O
show the reaction diagram
additional information
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
tryprostatin A + NADPH + H+ + O2
fumitremorgin C + NADP+ + 2 H2O
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
heme
heme-thiolate protein (P-450)
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.21.10)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)