Information on EC 1.14.19.B6 - tryptophan 6-halogenase
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The expected taxonomic range for this enzyme is: Streptomyces toxytricini
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1.14.19.B6
preliminary BRENDA-supplied EC number
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tryptophan 6-halogenase
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D-tryptophan + FADH2 + Cl- + O2 + H+ = 6-chloro-D-tryptophan + FAD + 2 H2O
L-tryptophan + FADH2 + Cl- + O2 + H+ = 6-chloro-L-tryptophan + FAD + 2 H2O
D-tryptophan + FADH2 + Cl- + O2 + H+ = 6-chloro-D-tryptophan + FAD + 2 H2O

(1)
D-tryptophan + FADH2 + Cl- + O2 + H+ = 6-chloro-D-tryptophan + FAD + 2 H2O
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L-tryptophan + FADH2 + Cl- + O2 + H+ = 6-chloro-L-tryptophan + FAD + 2 H2O

(1)
L-tryptophan + FADH2 + Cl- + O2 + H+ = 6-chloro-L-tryptophan + FAD + 2 H2O
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tryptophan:FADH2 oxidoreductase (6-halogenating)
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UniProt
brenda
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D-tryptophan + FADH2 + Cl- + O2 + H+
6-chloro-D-tryptophan + FAD + 2 H2O
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?
L-tryptophan + FADH2 + Br- + O2 + H+
6-bromo-L-tryptophan + FAD + 2 H2O
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L-tryptophan + FADH2 + Cl- + O2 + H+
6-chloro-L-tryptophan + FAD + 2 H2O
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0.021
L-tryptophan
pH 6.0, 28°C
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0.0255
L-tryptophan
pH 6.0, 28°C
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1.2
L-tryptophan
pH 6.0, 28°C
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5 - 7
pH 5.0: about 75% of maximal activity, pH 7.0: about 70% of maximal activity
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35 - 45
35°C: about 75% of maximal activity, 45°C: about 75% of maximal activity
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59000
x * 59000, SDS-PAGE
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His6-tagged enzyme is expressed in Escherichia coli RIL
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E9P162_9ACTN
523
58720
TrEMBL
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Zeng, J.; Zhan, J.
Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini
Biotechnol. Lett.
33
1607-1613
2011
Streptomyces toxytricini (E9P162), Streptomyces toxytricini
brenda
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