Information on EC 1.14.19.7 - (S)-2-hydroxypropylphosphonic acid epoxidase
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The expected taxonomic range for this enzyme is: Streptomyces wedmorensis
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(S)-2-hydroxypropylphosphonic acid epoxidase
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(S)-2-hydroxypropylphosphonic acid epoxidase
(S)-2-hydroxypropylphosphonic acid epoxidase

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(S)-2-hydroxypropylphosphonic acid epoxidase
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HPP epoxidase

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HppE

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UniProt
brenda
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-
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brenda
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(R)-2-hydroxypropylphosphonate + NADH + H+ + O2
2-oxopropylphosphonic acid + NAD+ + H2O
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
(R)-2-hydroxypropylphosphonate + NADH + H+ + O2

2-oxopropylphosphonic acid + NAD+ + H2O
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-
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-
?
(R)-2-hydroxypropylphosphonate + NADH + H+ + O2
2-oxopropylphosphonic acid + NAD+ + H2O
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-
-
?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2

(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
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-
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-
?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
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-
i.e. fosfomycin
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?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
-
i.e. fosfomycin
-
?
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(R)-2-hydroxypropylphosphonate + NADH + H+ + O2
2-oxopropylphosphonic acid + NAD+ + H2O
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
(R)-2-hydroxypropylphosphonate + NADH + H+ + O2

2-oxopropylphosphonic acid + NAD+ + H2O
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-
-
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?
(R)-2-hydroxypropylphosphonate + NADH + H+ + O2
2-oxopropylphosphonic acid + NAD+ + H2O
Q56185
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?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2

(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
-
-
-
-
?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
-
-
i.e. fosfomycin
-
?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O
Q56185
-
i.e. fosfomycin
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Fe2+

required
Fe2+
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required for activity
Iron

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a non-heme iron enzyme
Iron
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a mononuclear non-heme iron-dependent enzyme
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Milaczewska, A.; Broclawik, E.; Borowski, T.
On the catalytic mechanism of (S)-2-hydroxypropylphosphonic acid epoxidase (HppE): a hybrid DFT study
Chemistry
19
771-781
2013
Streptomyces wedmorensis (Q56185)
brenda
Huang, H.; Chang, W.C.; Pai, P.J.; Romo, A.; Mansoorabadi, S.O.; Russell, D.H.; Liu, H.W.
Evidence for radical-mediated catalysis by HppE: a study using cyclopropyl and methylenecyclopropyl substrate analogues
J. Am. Chem. Soc.
134
16171-16174
2012
Streptomyces wedmorensis
brenda
Chang, W.C.; Mansoorabadi, S.O.; Liu, H.W.
Reaction of HppE with substrate analogues: evidence for carbon-phosphorus bond cleavage by a carbocation rearrangement
J. Am. Chem. Soc.
135
8153-8156
2013
Streptomyces wedmorensis
brenda
Chang, W.C.; Dey, M.; Liu, P.; Mansoorabadi, S.O.; Moon, S.J.; Zhao, Z.K.; Drennan, C.L.; Liu, H.W.
Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction
Nature
496
114-118
2013
Streptomyces wedmorensis
brenda
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