Information on EC 1.14.19.40 - hex-5-enoyl-[acyl-carrier protein] acetylenase

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The expected taxonomic range for this enzyme is: Moorea producens

top print hide
EC NUMBER
COMMENTARY hide
1.14.19.40
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top print hide
RECOMMENDED NAME
GeneOntology No.
hex-5-enoyl-[acyl-carrier protein] acetylenase
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top print hide
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hex-5-enoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = hex-5-ynoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
show the reaction diagram
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top print hide
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
5-hexynoate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
hex-5-enoyl-[acyl-carrier protein],reduced ferredoxin:oxygen oxidoreductase (5,6-dehydrogenating)
The enzyme, characterized from the marine cyanobacterium Moorea producens, is involved in production of the ion channel blocker jamaicamide A. It is specific for hexanoate or hex-5-enoate loaded onto a dedicated acyl-carrier protein (JamC), which is encoded by a gene in the same operon.
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top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
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Manually annotated by BRENDA team
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
hex-5-enoyl-[acyl-carrier protein CamC] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
hex-5-ynoyl-[acyl-carrier protein CamC] + oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
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?
hex-5-enoyl-[acyl-carrier protein JamC] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
hex-5-ynoyl-[acyl-carrier protein JamC] + oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
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?
additional information
?
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the enzyme fails to act on 5-hexenoic acid or 5-hexenoyl-CoA
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top print hide
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ferredoxin
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top print hide
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
top print hide
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.19.40)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)