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Enzyme Nomenclature
Information on EC 1.14.19.24 - acyl-CoA 11-(E)-desaturase
Word Map on EC 1.14.19.24
- 1.14.19.24
-
pheromone
- moth
-
desaturation
-
delta9
-
spodoptera
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blend
- littoralis
- borer
-
lepidoptera
-
deuterium-labeled
- helicoverpa
- ostrinia
-
adzuki
-
hexadecanoic
- assulta
-
front-end
- furnacalis
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histidine-rich
-
trichoplusia
-
tetradecanoic
- armigera
-
thalassiosira
-
gland-specific
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biosynthesize
- pseudonana
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.14.19.24
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RECOMMENDED NAME
GeneOntology No.
acyl-CoA 11-(E)-desaturase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
a single enzyme may be responsible for the formation of both (Z)- and (E)-11-tetradecanoic acids. It is also possible that two mechanistically identical discrete enzymes are involved in each desaturation; reaction involves a first slow, isotope-sensitive C11-H cleavage, with probable formation of an unstable intermediate, followed by a second fast C12-H bond removal
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an acyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = an (11E)-enoyl-CoA + 2 ferricytochrome b5 + 2 H2O
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
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reduction
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (11,12 trans-dehydrogenating)
Involved in sex pheromone synthesis in the Lepidoptera (moths). The enzyme from the moth Spodoptera littoralis prefers 13:0 and 14:0 substrates. The product is formed by the stereospecific removal of the pro-R H at C-11 and the pro-S H at C-12. cf. EC 1.14.19.5, acyl-CoA 11-(Z)-desaturase.
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CAS REGISTRY NUMBER
COMMENTARY
199543-17-4
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(9E)-tetradecenoate + acceptor + O2 + H+
(9E,11E)-tetradecadienoate + ?
-
-
-
?
hexadecanoate + acceptor + O2 + H+
(11E)-hexadecenoate + ?
-
-
-
?
tetradecanoate + acceptor + O2 + H+
(11E)-tetradecenoate + ?
-
-
-
?
tetradecenoyl-CoA + acceptor + O2 + H+
(Z)-11-tetradecenoic acid + (E)-11-tetradecenoic acid + ?
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product ratio of 6:1 (Z:E)
-
?
additional information
?
-
the enzyme exhibits no activity with C16 and C18 precursor acids
-
-
-
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
-
-
?
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
a single enzyme may be responsible for the formation of both (Z)- and (E)-11-tetradecanoic acids. It is also possible that two mechanistically identical discrete enzymes are involved in each desaturation
-
?
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
-
-
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(9E)-tetradecenoate + acceptor + O2 + H+
(9E,11E)-tetradecadienoate + ?
Q95UJ3
-
-
-
?
hexadecanoate + acceptor + O2 + H+
(11E)-hexadecenoate + ?
Q95UJ3
-
-
-
?
tetradecanoate + acceptor + O2 + H+
(11E)-tetradecenoate + ?
Q95UJ3
-
-
-
?
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
a single enzyme may be responsible for the formation of both (Z)- and (E)-11-tetradecanoic acids. It is also possible that two mechanistically identical discrete enzymes are involved in each desaturation
-
-
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
-
-
myristoyl-CoA + reduced acceptor + O2
(E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
-
enzyme is involved in the biosynthesis of Spodoptera littoralis sex pheromone
-
?
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.19.24)
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