Information on EC 1.14.19.15 - (11Z)-hexadec-11-enoyl-CoA conjugase

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The expected taxonomic range for this enzyme is: Bombyx mori

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EC NUMBER
COMMENTARY hide
1.14.19.15
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RECOMMENDED NAME
GeneOntology No.
(11Z)-hexadec-11-enoyl-CoA conjugase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2 = (10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + 2 H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
bombykol biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(11Z)-hexadec-11-enoyl-CoA,reduced acceptor:oxygen 10,13-allylic oxidase (10E,12E-forming)
The enzyme, characterized from the silk moth Bombyx mori, catalyses a step in the pathway for the biosynthesis of bombykol, a sex pheromone produced by the moth. The enzyme converts a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds. Prior to catalysing this reaction, the enzyme catalyses the introduction of the cis bond in position 11 (cf. EC 1.14.19.5, acyl-CoA 11-desaturase).
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2
(10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + H2O
show the reaction diagram
(Z)-11-hexadecenoic acid + reduced acceptor + O2
?
show the reaction diagram
Q9NDH3
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?
additional information
?
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Q9NDH3
the enzyme possesses both Z11 desaturation and DELTA10,12-desaturation activities
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2
(10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + H2O
show the reaction diagram
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Sf9 cells
Q9NDH3
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.19.15)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)