Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.14.19.1 - stearoyl-CoA 9-desaturase and Organism(s) Mesocricetus auratus and UniProt Accession Q64420

for references in articles please use BRENDA:EC1.14.19.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mesocricetus auratus
UNIPROT: Q64420
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mesocricetus auratus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
scd, stearoyl-coa desaturase, fatty acid desaturase, scd-1, stearoyl-coa desaturase 1, stearoyl-coa desaturase-1, stearoyl coa desaturase, stearoyl-coenzyme a desaturase, delta9-desaturase, delta9 desaturase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
stearoyl-CoA desaturase
-
acyl coenzyme A desaturase
-
-
-
-
acyl-CoA desaturase
-
-
-
-
DELTA9-acyl CoA desaturase
-
-
-
-
DELTA9-desaturase
-
-
-
-
eicosatrienoyl-CoA desaturase
-
-
-
-
fatty acid 9-desaturase
-
-
-
-
fatty acid DELTA9-desaturase
-
-
-
-
fatty acid desaturase
-
-
-
-
fatty acyl CoA DELTA9-desaturase
-
-
-
-
fatty acyl DELTA9-desaturase
-
-
-
-
fatty acyl-CoA desaturase
-
-
-
-
long-chain fatty acid DELTA9-desaturase
-
-
-
-
palmitoyl CoA desaturase
-
-
-
-
palmitoyl-CoA desaturase
-
-
-
-
stearoyl CoA desaturase
-
-
stearoyl coenzyme A desaturase
-
-
-
-
stearoyl-CoA (DELTA8) desaturase
-
-
-
-
stearoyl-CoA desaturase
stearyl coenzyme A desaturase
-
-
-
-
stearyl-CoA desaturase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-34-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
additional information
?
-
-
inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, key enzyme in lipid metabolism and energy expenditure in mammals, overview
-
-
?
additional information
?
-
-
inhibition of the enzyme in cholesterol-fed hamsters leads to reduced overall body weight and adipose tissue deposition, while enzyme inhibition in absence of cholesterol does not. Enzyme inhibition induces hypercholesterinemia, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ferrocytochrome b5
dependent on, the enzyme also requires the presence of NADH-cytochrome b5 reductase
ferrocytochrome b5
dependent on, the enzyme also requires the presence of NADH-cytochrome b5 reductase
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
sterculic oil
-
in vivo enzyme inhibition by feeding sterculic oil
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
the enzyme expression is increased by feeding of cholesterol and sterculic oil in parallel, enzyme expression levels and metabolic effects, overview
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene SCD3 or FAR-17c; male hamsters, isozyme SCD3
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression level of isozyme SCD2
Manually annotated by BRENDA team
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SCD_MESAU
354
4
40968
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
x * 40000, recombinant enzyme, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 40000, recombinant enzyme, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant isozyme SCD3 partially from transfected HEL-293 cells by microsome preparation
recombinant isozyme SCD1 partially from transfected HEL-293 cells by microsome preparation
recombinant isozyme SCD2 partially from transfected HEL-293 cells by microsome preparation
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isozyme SCD3, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes
isozyme SCD1, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes
isozyme SCD2, DNA and amino acid sequence determination and analysis, sequence comparisons, expression in HEK-293 cell microsomes
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Major, C.A.; Ryan, K.; Bennett, A.J.; Lock, A.L.; Bauman, D.E.; Salter, A.M.
Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster
J. Lipid Res.
49
1456-1465
2008
Mesocricetus auratus
Manually annotated by BRENDA team
Wang, J.; Yu, L.; Wang, H.; Gao, Y.; Schrementi, J.P.; Porter, R.K.; Yurek, D.A.; Kuo, M.; Suen, C.S.; Cao, G.; Bean, J.S.; Kauffman, R.F.; Qian, Y.
Identification and characterization of hamster stearoyl-CoA desaturase isoforms
Lipids
43
197-205
2008
Mesocricetus auratus (A7LCI9), Mesocricetus auratus (A7LCJ0), Mesocricetus auratus (Q64420), Mesocricetus auratus
Manually annotated by BRENDA team