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Information on EC 1.14.18.1 - tyrosinase and Organism(s) Homo sapiens and UniProt Accession P14679
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1.14.18.1 tyrosinaseIUBMB Comments
A type III copper protein found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. The enzyme, which is activated upon binding molecular oxygen, can catalyse both a monophenolase reaction cycle (reaction 1) or a diphenolase reaction cycle (reaction 2). During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an o-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an o-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state . The second reaction is identical to that catalysed by the related enzyme catechol oxidase (EC 1.10.3.1). However, the latter can not catalyse the hydroxylation or monooxygenation of monophenols.
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Word Map
- 1.14.18.1
- melanin
- melanoma
- melanocyte
-
melanogenesis
- melanosomes
-
cosmetic
-
microphthalmia-associated
- hyperpigmentation
-
melanogenic
- catechols
- polyphenols
-
kojic
- copper
- albinism
-
whitening
- hair
-
keratinocytes
-
albino
- flavonoid
-
biosensors
- o-quinone
-
amperometric
-
phytochemical
-
pigmentary
- vitiligo
-
tautomerase
- laccase
- abts
- alpha-msh
-
melanization
-
depigmentation
- hydroquinone
-
electrode
-
melanocortins
-
2,2-diphenyl-1-picrylhydrazyl
-
copper-binding
- polyphenoloxidase
-
frap
- biotechnology
- agriculture
- pharmacology
-
hla-a2
- nutrition
-
1,1-diphenyl-2-picrylhydrazyl
- food industry
- hemocyanins
- environmental protection
- l-3,4-dihydroxyphenylalanine
-
crest-derived
- drug development
- microphthalmia
- medicine
- agaricus
- butyrylcholinesterase
-
melanoma-associated
-
copper-containing
-
decolor
- bisporus
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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=
+
2
+
=
2
+
2
Synonyms
tyrosinase, monophenolase, oxygen oxidoreductase, phenol oxidases, murine tyrosinase, melc2, o-diphenol oxidase, monophenol oxidase, met-tyrosinase, jrppo1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
catechol oxidase
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-
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catecholase
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chlorogenic acid oxidase
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-
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chlorogenic oxidase
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-
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cresolase
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-
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Diphenol oxidase
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-
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dopa oxidase
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-
-
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monophenol dihydroxyphenylalanine:oxygen oxidoreductase
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-
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monophenol monooxidase
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-
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monophenol oxidase
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-
-
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monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase
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-
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monophenol, dihydroxyphenylalanine:oxygen oxidoreductase
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copper binding metalloenzyme
monophenolase
N-acetyl-6-hydroxytryptophan oxidase
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-
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o-diphenol oxidase
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-
-
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o-diphenol oxidoreductase
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-
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o-diphenol:O2 oxidoreductase
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-
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o-diphenol:oxygen oxidoreductase
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-
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o-diphenolase
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-
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phenol oxidase
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-
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phenolase
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-
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polyaromatic oxidase
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-
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polyphenol oxidase
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polyphenolase
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pyrocatechol oxidase
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-
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tyrosinase
tyrosine-dopa oxidase
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-
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monophenolase
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tyrosinase
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tyrosinase
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this enzyme is able to catalyse two different reactions: the hydroxylation of monophenols to o-diphenols (monophenolase or cresolase activity, EC 1.14.18.1), and the oxidation of o-diphenols to o-quinones (diphenolase or catechol oxidase activity, EC 1.10.3.1)
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-tyrosine + O2 = dopaquinone + H2O
catalytic cycle, reaction mechanism, active site structure
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
redox reaction
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-
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oxidation
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reduction
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-
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
-
-, -, -
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SYSTEMATIC NAME
IUBMB Comments
L-tyrosine,L-dopa:oxygen oxidoreductase
A type III copper protein found in a broad variety of bacteria, fungi, plants, insects, crustaceans, and mammals, which is involved in the synthesis of betalains and melanin. The enzyme, which is activated upon binding molecular oxygen, can catalyse both a monophenolase reaction cycle (reaction 1) or a diphenolase reaction cycle (reaction 2). During the monophenolase cycle, one of the bound oxygen atoms is transferred to a monophenol (such as L-tyrosine), generating an o-diphenol intermediate, which is subsequently oxidized to an o-quinone and released, along with a water molecule. The enzyme remains in an inactive deoxy state, and is restored to the active oxy state by the binding of a new oxygen molecule. During the diphenolase cycle the enzyme binds an external diphenol molecule (such as L-dopa) and oxidizes it to an o-quinone that is released along with a water molecule, leaving the enzyme in the intermediate met state. The enzyme then binds a second diphenol molecule and repeats the process, ending in a deoxy state [7]. The second reaction is identical to that catalysed by the related enzyme catechol oxidase (EC 1.10.3.1). However, the latter can not catalyse the hydroxylation or monooxygenation of monophenols.
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CAS REGISTRY NUMBER
COMMENTARY
9002-10-2
not distinguished from EC 1.10.3.1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-tyrosine + L-dopa + O2
L-dopa + dopaquinone + H2O
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o-dopaquinone is unstable in aqueous solution and rapidly suffers a non-enzymatic cyclization to leukodopachrome
-
?
L-tyrosine + L-dopa + O2
L-dopa + dopaquinone + H2O
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pathway of melanin biosynthesis, detailed overview
cytotoxicity of L-DOPA
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?
additional information
?
-
no activity with [3-(3,5-dihydroxyphenyl)-1-propanoic acid]
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-
?
additional information
?
-
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no activity with [3-(3,5-dihydroxyphenyl)-1-propanoic acid]
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-
?
additional information
?
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-
tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair, various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation
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-
?
additional information
?
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the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview
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-
?
additional information
?
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tyrosinase is a copper-containing enzyme that catalyzes two distinct reactions of melanin synthesis: the hydroxylation of tyrosine by monophenolase action and the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA) to o-dopaquinone by diphenolase action
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair, various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation
-
-
?
L-tyrosine + L-dopa + O2
L-dopa + dopaquinone + H2O
-
pathway of melanin biosynthesis, detailed overview
cytotoxicity of L-DOPA
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
if L-DOPA is an active cofactor, its formation as an intermediate during o-dopaquinone production is controversial
-
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Cu2+
Cu2+
H2O2
-
the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers, conferring a distinct O2-Cu(II) charge transfer
Cu2+
a copper-containing enzyme, the two copper ions (CuA and CuB) essential for activity
Cu2+
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bound to the enzyme, the central domain contains two copper binding sites, mettyrosinase, the resting form of tyrosinase, contains two tetragonal Cu(II) ions antiferromagnetically coupled through an endogenous bridge, although hydroxide exogenous ligands other than peroxide are bound to the copper site, the exogenous oxygen molecule is bound as peroxide and bridges the two copper centers
Cu2+
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tyrosinases is a copper-containing enzyme belonging to the type 3 copper protein family
Cu2+
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a copper-containing enzyme, copper is an important element for tyrosinase activity, binding to tyrosinase depends on pH in melanosomes
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
arbutin
a glycosylated benzoquinone, ascorbic acid reduces melanin formation via reduction of dopaquinone
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dihydroxyphenyl)ethyl]prop-2-enamide
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67% inhibition at 0.1 mM
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
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100% inhibition at 0.1 mM
(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-phenylethyl)prop-2-enamide
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19% inhibition at 0.1 mM
(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]prop-2-enamide
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40% inhibition at 0.1 mM
(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide
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49% inhibition at 0.1 mM
(2E)-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
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62% inhibition at 0.1 mM
(2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
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25% inhibition at 0.1 mM
(S)-imperanene
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inhibitor in rum distillate wastewater significantly inhibits tyrosinase isolated from HMV-II cells, competitive inhibition. The inhibitory activities in descending order are (S)-imperanene 4-O-beta-D-glucopyranosyl imperanene, 4-O-beta-D-glucopyranosyl-3-methoxy imperanene
(Z)-2-(4-hydroxybenzylidene)-4-hydroxybenzofuran-3(2H)-one
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71% inhibition at 0.1 mM
(Z)-2-(4-hydroxybenzylidene)-6-hydroxybenzofuran-3(2H)-one
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69% inhibition at 0.1 mM
(Z)-4,6-dihydroxy-2-(4-methoxybenzylidene)benzofuran-3(2H)-one
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11% inhibition at 0.1 mM
2-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acetamide
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34% inhibition at 0.1 mM
2-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acetamide
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16% inhibition at 0.1 mM
2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
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acetazolamideor ACZ, in vitro, in vivo, and in silico studies, inhibition kinetics. Acetazolamide is a a noncompetitive inhibitor without cytotoxic effect showing inhibition of tyrosinase expression in L-DOPA-induced melanoma. Molecular dynamics simulations, overview
3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]propanamide
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94% inhibition at 0.1 mM
3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]propanamide
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28% inhibition at 0.1 mM
3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]propanamide
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96% inhibition at 0.1 mM
3-hydroxyphloretin
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constituents from the formosan apple (Malus doumeri var. formosana), inhibition 73%, shows substantial cellular tyrosinase inhibitory activity at a concentration of 100 microM
4-O-beta-D-glucopyranosyl imperanene
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inhibitor in rum distillate wastewater significantly inhibits tyrosinase isolated from HMV-II cells. The inhibitory activities in descending order are (S)-imperanene, 4-O-beta-D-glucopyranosyl imperanene, 4-O-beta-D-glucopyranosyl-3-methoxy imperanene
4-O-beta-D-glucopyranosyl-3-methoxy imperanene
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inhibitor in rum distillate wastewater significantly inhibits tyrosinase isolated from HMV-II cells. The inhibitory activities in descending order are (S)-imperanene, 4-O-beta-D-glucopyranosyl imperanene, 4-O-beta-D-glucopyranosyl-3-methoxy imperanene
5-hydroxy-2-(hydroxymethyl)-2H-pyran-4-one
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1.12 mM, 50% inhibition of recombinant enzyme
ascorbic acid
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exhibits less tyrosinase-inhibitory activity than 3-hydroxyphloretin or catechol
catechol
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constituents from the formosan apple (Malus doumeri var. formosana), inhibition 78%, shows substantial cellular tyrosinase inhibitory activity at a concentration of 100 microM
Cl-
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enzyme added to substrate L-dopa, that is mixed with various concentrations of NaCl in 0.05 M sodium phosphate buffer, pH 7.0. When the NaCl concentration reaches to 600 mM, almost all the enzyme activity is abolished. Cl- induced inhibition of human tyrosinase, Cl- inhibits tyrosinase in a slope-parabolic competitive manner. TXM13 originated tyrosinase and the overexpressed human tyrosinase in HEK293 cells are inhibited. The inhibition by Cl- is reversible
ellagic acid
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exhibits less tyrosinase-inhibitory activity than 3-hydroxyphloretin or catechol
L-ascorbic acid
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as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells
N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)propanamide
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42% inhibition at 0.1 mM
polyvinylpyrrolidone (PVP)-wrapped fullerene derivative
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inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene, named Radical Sponge. As compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells
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arbutin
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as compared with two major effective cosmetic additives, arbutin and L-ascorbic acid, the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) shows the more marked depigmenting effect in human melanocytes or melanoma cells
hydroquinone
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exhibits less tyrosinase-inhibitory activity than 3-hydroxyphloretin or catechol, very toxic to HEMn cell
additional information
automated docking calculations for inhibitor docking to the enzyme structure model, molecular dynamics, overview. Intermolecular interactions and effectiveness of specific inhibition. Residues N81, N260, H263, and M280 are involved in the binding of inhibitors to mushroom tyrosinase. E195 and H208 are important residues in bacterial tyrosinase, while E230, S245, N249, H252, V262, and S265 bind to inhibitors and are important in forming Pi interaction in human tyrosinase
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additional information
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automated docking calculations for inhibitor docking to the enzyme structure model, molecular dynamics, overview. Intermolecular interactions and effectiveness of specific inhibition. Residues N81, N260, H263, and M280 are involved in the binding of inhibitors to mushroom tyrosinase. E195 and H208 are important residues in bacterial tyrosinase, while E230, S245, N249, H252, V262, and S265 bind to inhibitors and are important in forming Pi interaction in human tyrosinase
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additional information
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tyrosinase activity is inhibited by an unknown epidermal protein
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additional information
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in vitro and in vivo inhibitory potency of natural compounds, inhibition of melanogenesis, overview
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additional information
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inhibitory potency of different aurones, no inhibition by apigenin, (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one, (Z)-2-(4-ethylbenzylidene)-6-hydroxybenzofuran-3(2H)-one, (Z)-benzylidene-4,6-dihydroxybenzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(4-ethylbenzylidene)benzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(2-ethylbenzylidene)benzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(2-hydroxybenzylidene)benzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(4-ethyloxybenzylidene)benzofuran-3(2H)-one, (Z)-2-(4-tert-butylbenzylidene)-4,6-dihydroxybenzofuran-3(2H)-one, (Z)-4,6-dihydroxy-2-(4-propylbenzylidene)benzofuran-3(2H)-one, and (Z)-4,6-dihydroxy-2-(4-hydroxy-3-methoxybenzylidene)benzofuran-3(2H)-one, overview, cytotoxic effects on melanocytes depend on the skin color type of the origin, overview
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additional information
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melanin plays a crucial protective role against skin photocarcinogenesis, however, the production of abnormal melanin pigmentation is a serious esthetic problem in humans, melanin biosynthesis can be inhibited by avoiding UV exposure, the inhibition of tyrosinase, the inhibition of melanocyte metabolism and proliferation, or the removal of melanin with corneal ablation, overview, structure, application and importance of inhibitors, overview
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additional information
-
no inhibition by N-[2-(3,4-dihydroxyphenyl)ethyl]-2-(4-hydroxy-3-methoxyphenyl)acetamide at 0.1 mM
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-morpholinoethyl (E)-3-(3,4-dihydroxyphenyl)acrylate
a caffeic acid-4-(2-hydroxyethyl) morpholine ester, increases tyrosinase activity in M14 cells in a dose-dependent manner
3-morpholinopropyl (E)-3-(3,4-dihydroxyphenyl)acrylate
a caffeic acid-4-(2-hydroxyethyl) morpholine ester, increases tyrosinase activity in M14 cells in a dose-dependent manner
membrane-associated transporter protein
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MATP, encoded by gene SLC45A2, regulates melanosomal pH and influences tyrosinase activity, mechanism modeling, overview. The SLC45A2 transcript is highly expressed in human melanoma cells and primary melanocyte. Knockdown of MATP using siRNAs reduces melanin content and tyrosinase activity without any morphological change in melanosomes or the expression of melanogenesis-related proteins, and lowers the the melanosomal pH. The reduced tyrosinase activity in MATP-knockdown cells is due to improper copper binding to tyrosinase under the acidic conditions in melanosomes and that the acidic conditions are due to MATP deletion
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additional information
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UVA induced oxidative stress is considered to promote melanogenesis and serious skin damage. UVA-induced reactive oxygen species (ROS), ROS causes tyrosinase gene transcription
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase.
Adenocarcinoma
The role of the detection of hematogenous micrometastasis in prostate adenocarcinoma and malignant melanoma by RT-PCR.
Adrenal Hyperplasia, Congenital
Steroid 21-hydroxylase deficiency: three additional mutated alleles and establishment of phenotype-genotype relationships of common mutations.
Albinism
A novel nonsense mutation in the tyrosinase gene is related to the albinism in a capuchin monkey (Sapajus apella).
Albinism
A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2).
Albinism
A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85.
Albinism
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
Albinism
A trinucleotide deletion together with a base duplication event at codon 439 in the human tyrosinase gene identifies a mutational hotspot.
Albinism
AAV-mediated Tyrosinase Gene Transfer Restores Melanogenesis and Retinal Function in a Model of Oculo-cutaneous Albinism Type I (OCA1).
Albinism
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Albinism
Albinism and amelanotic melanoma: occurrence in a child with positive test results for tyrosinase.
Albinism
Albinism in the American mink (Neovison vison) is associated with a tyrosinase nonsense mutation.
Albinism
Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation.
Albinism
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Albinism
Analysis of tyrosinase gene mutations using direct automated infrared fluorescence DNA sequencing of amplified exons.
Albinism
Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects.
Albinism
Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism.
Albinism
Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression.
Albinism
Cas9 ribonucleoprotein complex allows direct and rapid analysis of coding and noncoding regions of target genes in Pleurodeles waltl development and regeneration.
Albinism
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Albinism
Characterization of human hairbulb tyrosinase: properties of normal and albino enzyme.
Albinism
Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence.
Albinism
Conversations with ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development.
Albinism
Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice.
Albinism
Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits.
Albinism
CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3' UTR induce graying in rabbit.
Albinism
Detection of 53 novel DNA variations within the tyrosinase gene and accumulation of mutations in 17 patients with albinism.
Albinism
Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Albinism
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Albinism
Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin.
Albinism
Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection.
Albinism
Functional assessment of tyrosinase variants identified in individuals with albinism is essential for unequivocal determination of genotype to phenotype correlation.
Albinism
FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis.
Albinism
Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B).
Albinism
Identification of a tyrosinase (TYR) exon 4 deletion in albino ferrets (Mustela putorius furo).
Albinism
Insertional mutagenesis by a hybrid piggyBac and sleeping beauty transposon in the rat.
Albinism
l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation.
Albinism
Molecular cloning and expression analysis of tyr and tyrp1 genes in normal and albino yellow catfish Tachysurus fulvidraco.
Albinism
Molecular cloning, gene expression in albino mutants and gene knockdown studies of tyrosinase mRNA in rainbow trout.
Albinism
Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.
Albinism
Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase.
Albinism
Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.
Albinism
One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B.
Albinism
Phenotypic rescue of the albino mutation in the medakafish (Oryzias latipes) by a mouse tyrosinase transgene.
Albinism
Prenatal diagnosis of oculocutaneous albinism by analysis of the fetal tyrosinase gene.
Albinism
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis.
Albinism
Structural insight with mutational impact on tyrosinase and PKC-? interaction from Homo sapiens: Molecular modeling and docking studies for melanogenesis, albinism and increased risk for melanoma.
Albinism
The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation in a highly conserved position of the tyrosinase (TYR) gene deduced protein.
Albinism
Tyrosinase expression during neuroblast divisions affects later pathfinding by retinal ganglion cells.
Albinism
Tyrosinase positive albinism with familial 46,XY,t(2;4) (q31.2;q31.22) balanced translocation.
Albinism
Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4.
Albinism
Yellow mutant albinism: cytochemical, ultrastructural, and genetic characterization suggesting multiple allelism.
Albinism, Ocular
Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism.
Albinism, Ocular
Interaction between G Protein-Coupled Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type 1.
Albinism, Ocular
Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
Albinism, Ocular
Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism.
Albinism, Ocular
Sequence analysis of tyrosinase gene in ocular and oculocutaneous albinism patients: introducing three novel mutations.
Albinism, Ocular
The ocular albinism type 1 (OA1) gene controls melanosome maturation and size.
Albinism, Ocular
The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism.
Albinism, Oculocutaneous
A common temperature-sensitive allelic form of human tyrosinase is retained in the endoplasmic reticulum at the nonpermissive temperature.
Albinism, Oculocutaneous
A dinucleotide deletion (-delta GA115) in the tyrosinase gene responsible for type I-A (tyrosinase negative) oculocutaneous albinism in a Pakistani individual.
Albinism, Oculocutaneous
A frequent tyrosinase gene mutation associated with type I-A (tyrosinase-negative) oculocutaneous albinism in Puerto Rico.
Albinism, Oculocutaneous
A frequent tyrosinase gene mutation in classic, tyrosinase-negative (type IA) oculocutaneous albinism.
Albinism, Oculocutaneous
A genome-wide scan study identifies a single nucleotide substitution in the tyrosinase gene associated with white coat colour in a red deer (Cervus elaphus) population.
Albinism, Oculocutaneous
A nonsense mutation in the tyrosinase gene of Afghan patients with tyrosinase negative (type IA) oculocutaneous albinism.
Albinism, Oculocutaneous
A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China.
Albinism, Oculocutaneous
A novel mutation (delAACT) in the tyrosinase gene in a Cameroonian black with type 1A oculocutaneous albinism.
Albinism, Oculocutaneous
A novel mutation of the tyrosinase gene causing oculocutaneous albinism type 1 (OCA1).
Albinism, Oculocutaneous
A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism.
Albinism, Oculocutaneous
A splicing mutation of the tyrosinase gene causes yellow oculocutaneous albinism in a Japanese patient with a pigmented phenotype.
Albinism, Oculocutaneous
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
Albinism, Oculocutaneous
A tyrosinase gene missense mutation in temperature-sensitive type I oculocutaneous albinism. A human homologue to the Siamese cat and the Himalayan mouse.
Albinism, Oculocutaneous
African origin of an intragenic deletion of the human P gene in tyrosinase positive oculocutaneous albinism.
Albinism, Oculocutaneous
Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.
Albinism, Oculocutaneous
Analysis of mutations in the copper B binding region associated with type I (tyrosinase-related) oculocutaneous albinism.
Albinism, Oculocutaneous
Analysis of tyrosinase mutations associated with tyrosinase-related oculocutaneous albinism (OCA1).
Albinism, Oculocutaneous
Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system.
Albinism, Oculocutaneous
C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.
Albinism, Oculocutaneous
Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos.
Albinism, Oculocutaneous
Characterization of Temperature-Dependent Kinetics of Oculocutaneous Albinism-Causing Mutants of Tyrosinase.
Albinism, Oculocutaneous
Cloning and sequence analysis of the tyrosinase gene from a patient with tyrosinase-positive oculocutaneous albinism.
Albinism, Oculocutaneous
Coexpression of wild-type tyrosinase enhances maturation of temperature-sensitive tyrosinase mutants.
Albinism, Oculocutaneous
Comment on homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene.
Albinism, Oculocutaneous
Detection of 53 novel DNA variations within the tyrosinase gene and accumulation of mutations in 17 patients with albinism.
Albinism, Oculocutaneous
Detection of heterozygotes for tyrosinase-negative oculocutaneous albinism by hairbulb tyrosinase assay.
Albinism, Oculocutaneous
Detection of mutations in the tyrosinase gene in a patient with type IA oculocutaneous albinism.
Albinism, Oculocutaneous
Determination of variants in the 3'-region of the Tyrosinase gene requires locus specific amplification.
Albinism, Oculocutaneous
DNA-based prenatal diagnosis of a Korean family with tyrosinase-related oculocutaneous albinism (OCA1).
Albinism, Oculocutaneous
Dynamic analysis of human tyrosinase intra-melanosomal domain and mutant variants to further understand oculocutaneous albinism type 1.
Albinism, Oculocutaneous
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism.
Albinism, Oculocutaneous
Establishment of tyrosinase sequence database in normally pigmented Indians and Japanese for rapid determination of novel mutations.
Albinism, Oculocutaneous
Five novel mutations in tyrosinase gene of Japanese and Indian patients with oculocutaneous albinism type I (OCA1).
Albinism, Oculocutaneous
Functional assessment of tyrosinase variants identified in individuals with albinism is essential for unequivocal determination of genotype to phenotype correlation.
Albinism, Oculocutaneous
Functional in silico analysis of human tyrosinase and OCA1 associated mutations.
Albinism, Oculocutaneous
Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbits.
Albinism, Oculocutaneous
Genetic mapping of the dominant albino locus in rainbow trout (Oncorhynchus mykiss).
Albinism, Oculocutaneous
Hairbulb tyrosinase activity in oculocutaneous albinism: suggestions for pathway control and block location.
Albinism, Oculocutaneous
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: Effects of altering intracellular pH and pink-eyed dilution gene expression.
Albinism, Oculocutaneous
Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene.
Albinism, Oculocutaneous
Homozygous tyrosinase gene mutation in an American black with tyrosinase-negative (type IA) oculocutaneous albinism.
Albinism, Oculocutaneous
Human oculocutaneous albinism caused by single base insertion in the tyrosinase gene.
Albinism, Oculocutaneous
Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.
Albinism, Oculocutaneous
Human Tyrosinase: Temperature-Dependent Kinetics of Oxidase Activity.
Albinism, Oculocutaneous
Identification and characterization of a DNase hypersensitive region of the human tyrosinase gene.
Albinism, Oculocutaneous
Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B).
Albinism, Oculocutaneous
Identification of a missense mutation in the tyrosinase gene in a Chinese family with oculocutaneous albinism type 1.
Albinism, Oculocutaneous
Identification of genes from a schizophrenia-linked translocation breakpoint region.
Albinism, Oculocutaneous
Initiation codon mutation of the tyrosinase gene as a cause of human albinism.
Albinism, Oculocutaneous
Insertion/deletion mutations of type I oculocutaneous albinism in chinese patients from Taiwan.
Albinism, Oculocutaneous
Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects.
Albinism, Oculocutaneous
Loss of Oca2 disrupts the unfolded protein response and increases resistance to endoplasmic reticulum stress in melanocytes.
Albinism, Oculocutaneous
Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3.
Albinism, Oculocutaneous
Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation.
Albinism, Oculocutaneous
Molecular analysis of the DNA segments cross-hybridizable to the tyrosinase gene in patients affected with oculocutaneous albinism.
Albinism, Oculocutaneous
Molecular analysis of type I-A (tyrosinase negative) oculocutaneous albinism.
Albinism, Oculocutaneous
Molecular and Functional Studies of Tyrosinase Variants Among Indian Oculocutaneous Albinism Type 1 Patients.
Albinism, Oculocutaneous
Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan.
Albinism, Oculocutaneous
Molecular bases of tyrosinase-negative oculocutaneous albinism: a single base insertion or a missense point mutation in the tyrosinase gene.
Albinism, Oculocutaneous
Molecular basis of oculocutaneous albinism type 1 in Lebanese patients.
Albinism, Oculocutaneous
Molecular basis of type I (tyrosinase-related) oculocutaneous albinism: mutations and polymorphisms of the human tyrosinase gene.
Albinism, Oculocutaneous
Molecular basis of type IA (tyrosinase negative) oculocutaneous albinism.
Albinism, Oculocutaneous
Molecular basis of tyrosinase-negative oculocutaneous albinism. A single base mutation in the tyrosinase gene causing arginine to glutamine substitution at position 59.
Albinism, Oculocutaneous
Mutation analysis of the tyrosinase gene in oculocutaneous albinism.
Albinism, Oculocutaneous
Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3".
Albinism, Oculocutaneous
Mutational mapping of the catalytic activities of human tyrosinase.
Albinism, Oculocutaneous
Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase.
Albinism, Oculocutaneous
Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control.
Albinism, Oculocutaneous
Mutations of the human tyrosinase gene associated with tyrosinase related oculocutaneous albinism (OCA1). Mutations in brief no. 204. Online.
Albinism, Oculocutaneous
Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism.
Albinism, Oculocutaneous
Mutations of the tyrosinase gene in Indo-Pakistani patients with type I (tyrosinase-deficient) oculocutaneous albinism (OCA).
Albinism, Oculocutaneous
Mutations of the tyrosinase gene in patients with oculocutaneous albinism from various ethnic groups in Israel.
Albinism, Oculocutaneous
Mutations of the tyrosinase gene in three Korean patients with type I oculocutaneous albinism.
Albinism, Oculocutaneous
New animal models to study the role of tyrosinase in normal retinal development.
Albinism, Oculocutaneous
Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism.
Albinism, Oculocutaneous
Non-random distribution of missense mutations within the human tyrosinase gene in type I (tyrosinase-related) oculocutaneous albinism.
Albinism, Oculocutaneous
Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.
Albinism, Oculocutaneous
Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1).
Albinism, Oculocutaneous
OCA1 in different ethnic groups of india is primarily due to founder mutations in the tyrosinase gene.
Albinism, Oculocutaneous
Ocular albinism with absent foveal pits but without nystagmus, photophobia, or severely reduced vision.
Albinism, Oculocutaneous
Ocular findings in patients with oculocutaneous albinism type ia with G47D tyrosinase gene mutation in Puerto Rico: a case report.
Albinism, Oculocutaneous
Ocular motor behaviour of monozygotic twins with tyrosinase negative oculocutaneous albinism.
Albinism, Oculocutaneous
Oculocutaneous albinism and analysis of tyrosinase gene in Japanese patients.
Albinism, Oculocutaneous
Oculocutaneous albinism in Suncus murinus: establishment of a strain and identification of its responsible gene.
Albinism, Oculocutaneous
Oculocutaneous albinism in the i6 mutant of the medaka fish is associated with a deletion in the tyrosinase gene.
Albinism, Oculocutaneous
Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.
Albinism, Oculocutaneous
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Albinism, Oculocutaneous
Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wild-type proteins.
Albinism, Oculocutaneous
One-allele system in the Korean for MboI-RFLP in exon 1 of the human tyrosinase (TYR) gene.
Albinism, Oculocutaneous
Pathogenesis of the platinum (cp) mutation, a model for oculocutaneous albinism.
Albinism, Oculocutaneous
Polymorphic sequences of the tyrosinase gene: allele analysis on 16 OCA1 patients in Japan indicate that three polymorphic sequences in the tyrosinase gene promoter could be powerful markers for indirect gene diagnosis.
Albinism, Oculocutaneous
Prenatal diagnosis of oculocutaneous albinism by analysis of the fetal tyrosinase gene.
Albinism, Oculocutaneous
Prenatal diagnosis of oculocutaneous albinism type I: review and personal experience.
Albinism, Oculocutaneous
Prevalent and novel mutations of the tyrosinase gene in Korean patients with tyrosinase-deficient oculocutaneous albinism.
Albinism, Oculocutaneous
Progressive retinal degeneration in a girl with Knobloch syndrome who presented with signs of ocular albinism.
Albinism, Oculocutaneous
Purification of Recombinant Human Tyrosinase from Insect Larvae Infected with the Baculovirus Vector.
Albinism, Oculocutaneous
R278TER and P431L mutations of the tyrosinase gene exist in Japanese patients with tyrosinase-negative oculocutaneous albinism.
Albinism, Oculocutaneous
Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.
Albinism, Oculocutaneous
Role of the ubiquitin proteasome system in regulating skin pigmentation.
Albinism, Oculocutaneous
Sequence analysis of the human tyrosinase promoter from a patient with tyrosinase-negative oculocutaneous albinism.
Albinism, Oculocutaneous
Sequence analysis of tyrosinase gene in ocular and oculocutaneous albinism patients: introducing three novel mutations.
Albinism, Oculocutaneous
Sequence-based diagnosis of tyrosinase-related oculocutaneous albinism: successful sequence analysis of the tyrosinase gene from blood spots dried on filter paper.
Albinism, Oculocutaneous
Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.
Albinism, Oculocutaneous
Targeted Base Editing via RNA-Guided Cytidine Deaminases in Xenopus laevis Embryos.
Albinism, Oculocutaneous
Technical advances in prenatal diagnosis of tyrosinase-negative oculocutaneous albinism.
Albinism, Oculocutaneous
Temperature sensitive oculocutaneous albinism associated with missense changes in the tyrosinase gene.
Albinism, Oculocutaneous
Temperature-sensitive tyrosinase associated with peripheral pigmentation in oculocutaneous albinism.
Albinism, Oculocutaneous
The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase.
Albinism, Oculocutaneous
The molecular basis of oculocutaneous albinism type 1 (OCA1): sorting failure and degradation of mutant tyrosinases results in a lack of pigmentation.
Albinism, Oculocutaneous
The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism.
Albinism, Oculocutaneous
The tyrosinase gene and oculocutaneous albinism type 1 (OCA1): A model for understanding the molecular biology of melanin formation.
Albinism, Oculocutaneous
Three different frameshift mutations of the tyrosinase gene in type IA oculocutaneous albinism.
Albinism, Oculocutaneous
Two novel tyrosinase (TYR) gene mutations with pathogenic impact on oculocutaneous albinism type 1 (OCA1).
Albinism, Oculocutaneous
Type I oculocutaneous albinism associated with a full-length deletion of the tyrosinase gene.
Albinism, Oculocutaneous
Tyrosinase (TYR) gene sequencing and literature review reveals recurrent mutations and multiple population founder gene mutations as causative of oculocutaneous albinism (OCA) in Pakistani families.
Albinism, Oculocutaneous
Tyrosinase and ocular diseases: some novel thoughts on the molecular basis of oculocutaneous albinism type 1.
Albinism, Oculocutaneous
Tyrosinase gene (TYR) mutations in Chinese patients with oculocutaneous albinism type 1.
Albinism, Oculocutaneous
Tyrosinase gene analysis in Japanese patients with oculocutaneous albinism.
Albinism, Oculocutaneous
Tyrosinase gene mutations associated with type IB ("yellow") oculocutaneous albinism.
Albinism, Oculocutaneous
Tyrosinase gene mutations in oculocutaneous albinism 1 (OCA1): definition of the phenotype.
Albinism, Oculocutaneous
Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions.
Albinism, Oculocutaneous
Tyrosinase positive albinism with familial 46,XY,t(2;4) (q31.2;q31.22) balanced translocation.
Albinism, Oculocutaneous
Tyrosinase positive oculocutaneous albinism among the Zuni and the Brandywine triracial isolate: biochemical and clinical characteristics and fertility.
Albinism, Oculocutaneous
Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4.
Albinism, Oculocutaneous
Visual acuity development in tyrosinase negative oculocutaneous albinism.
Albinism, Oculocutaneous
Visual evoked potentials in Negro carriers of the gene for tyrosinase positive oculocutaneous albinism.
Albinism, Oculocutaneous
Yellow mutant albinism: cytochemical, ultrastructural, and genetic characterization suggesting multiple allelism.
Albinism, Oculocutaneous
[Early prenatal genetic diagnosis of oculocutaneous albinism type I in seven families].
Albinism, Oculocutaneous
[Mouse model of tyrosinase positive type oculocutaneous albinism (chinchilla mouse, Cch/Cch) : tyrosinase activity and ultrastructure of hair bulb melanocyte (author's transl)]
Albinism, Oculocutaneous
[Mutation screening of the TYR and P gene in three patients with oculocutaneous albinism]
Albinism, Oculocutaneous
[New nonsense mutation (p.E250X) in the tyrosinase gene of a patient with oculocutaneous albinism type 1A]
Albinism, Oculocutaneous
[Oculocutaneous albinism in French overseas territories (Reunion, French Guyana, Martinique) and Mayotte. Study of 21 cases in 16 families]
Albinism, Oculocutaneous
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Albinism, Oculocutaneous
[Study of tyrosinase gene mutation in oculocutaneous albinism type 1 patients].
Alopecia Areata
Altered T cell subpopulations and serum anti-TYRP2 and tyrosinase antibodies in the acute and chronic phase of alopecia areata in the C3H/HeJ mouse model.
Alopecia Areata
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata.
Alzheimer Disease
Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)
Alzheimer Disease
Biophenols: Enzymes (?-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.).
Alzheimer Disease
Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies.
Alzheimer Disease
Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems.
Alzheimer Disease
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts.
Alzheimer Disease
Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits.
Alzheimer Disease
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.
Alzheimer Disease
[Inhibitory effects of Rhodiola plants and their oligomeric proanthocyanidins on tyrosinase and Abeta42 aggregation].
Angiomyolipoma
Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas.
Angiomyolipoma
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Angiomyolipoma
Melanoma markers in angiomyolipoma of the liver and kidney: a comparative study.
Angiomyolipoma
Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum.
Anthrax
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
Arthritis
Oxindole and its derivatives: A review on recent progress in biological activities.
Asthma
Microbial biotransformation of bioactive and clinically useful steroids and some salient features of steroids and biotransformation.
Ataxia
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Ataxia Telangiectasia
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Autoimmune Diseases
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata.
Autoimmune Diseases
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient.
Autoimmune Diseases
Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease.
Avian Leukosis
Expression of virally transduced mouse tyrosinase in tyrosinase-negative chick embryo melanocytes in culture.
Avian Leukosis
Expression of virally-transduced mouse tyrosinase in cultured chick embryo cells.
Avian Leukosis
Tissue-specific expression of mouse tyrosinase gene in cultured chicken cells.
Bacterial Infections
Relationship of Agaricus bisporus mannose-binding protein to lectins with ?-trefoil fold.
Blindness
Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.
Bone Resorption
Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.
Bradycardia
Fixed patterns of bradycardia during late embryonic development in domestic fowl with C locus mutations.
Brain Neoplasms
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Breast Neoplasms
Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.
Breast Neoplasms
Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan.
Breast Neoplasms
Detection of tyrosinase mRNA in melanoma by reverse transcription-PCR and electrochemiluminescence.
Breast Neoplasms
Does melanin affect the low LET radiation response of Cloudman S91 mouse melanoma cell lines?
Breast Neoplasms
Orf239342 from the mushroom Agaricus bisporus is a mannose binding protein.
Breast Neoplasms
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Breast Neoplasms
Serum tyrosinase in malignant disease, its activity, and the electrophoretic patterns of the enzyme as carried by immunoglobulins'.
Breast Neoplasms
The challenging estrogen receptor-negative/ progesterone receptor-negative/HER-2-negative patient: a promising candidate for epidermal growth factor receptor-targeted therapy?
Breast Neoplasms
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Carcinogenesis
3D QSAR pharmacophore-based virtual screening for the identification of potential inhibitors of tyrosinase.
Carcinogenesis
Conjugation with Phospholipids as a Modification Increasing Anticancer Activity of Phenolic Acids in Metastatic Melanoma-In Vitro and In Silico Studies.
Carcinogenesis
Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors: Quercetin and the Central Role of p53.
Carcinogenesis
Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors.
Carcinogenesis
Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy.
Carcinoma
A comprehensive LC-MS/MS method validation for the quantitative investigation of 37 fingerprint phytochemicals in Achillea species: A detailed examination of A. coarctata and A. monocephala.
Carcinoma
Augmentation of melanoma-specific gene expression using a tandem melanocyte-specific enhancer results in increased cytotoxicity of the purine nucleoside phosphorylase gene in melanoma.
Carcinoma
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Carcinoma
Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies?
Carcinoma
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Carcinoma
Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum.
Carcinoma
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Carcinoma, Basal Cell
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Carcinoma, Hepatocellular
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, ?-lactamase enzyme inhibition studies.
Carcinoma, Hepatocellular
Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.
Carcinoma, Neuroendocrine
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Carcinoma, Renal Cell
Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies?
Carcinoma, Renal Cell
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Carcinoma, Renal Cell
Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum.
Carcinoma, Squamous Cell
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Carcinoma, Squamous Cell
Loss of tyrosinase activity confers increased skin tumor susceptibility in mice.
Cataract
Metabolic alteratios in experimental cataract. I. Inhibition of lactate dehydrogenase and appearance of O-diphenol oxidase in cataractous lens of naphthalene fed rabbits.
Cataract
[Experimental study on the relationship between experimental naphthalene cataract and iris color in the animal eye. III. Histochemical observation of o-diphenol oxidase activity in the iris and ciliary body in albino and pigmented rats]
Central Nervous System Neoplasms
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Chediak-Higashi Syndrome
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Chediak-Higashi Syndrome
Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
Cholera
Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in cloudman S91 melanoma cells after ultraviolet-irradiation.
Cholera
Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes.
Cholera
Melanogenesis in murine B16 cells exposed to Aeromonas hydrophila cytotoxic enterotoxin.
Cholera
Mitogenic, melanogenic, and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens.
Cholera
On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes.
Cholera
Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells.
Cholera
Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.
Cholera
Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines.
Cholera
Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF.
Cholera
Stimulation of tyrosinase in human melanocytes by pro-opiomelanocortin-derived peptides.
Coinfection
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport.
Colonic Neoplasms
Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan.
Colonic Neoplasms
Isolated organ perfusion does not result in systemic microembolization of tumor cells.
Congenital Abnormalities
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
cystathionine beta-synthase deficiency
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Cystic Fibrosis
A trinucleotide deletion together with a base duplication event at codon 439 in the human tyrosinase gene identifies a mutational hotspot.
Cystic Fibrosis
Different p97/VCP complexes function in retrotranslocation step of mammalian Er-associated degradation (ERAD).
Cystic Fibrosis
pSURF-2, a modified BAC vector for selective YAC cloning and functional analysis.
Deafness
Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I.
Dehydration
Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini.
Dermatitis
3D QSAR pharmacophore-based virtual screening for the identification of potential inhibitors of tyrosinase.
Dermatitis
Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).
Dermatitis, Exfoliative
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Dermatofibrosarcoma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Diabetes Mellitus
LC-MS/MS Profiles and In Vitro Biological Activities of Extracts of an Endemic Species from Turkey: Stachys cretica ssp. anatolica.
Diabetes Mellitus
Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits.
Diabetes Mellitus, Type 2
Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
Diabetes Mellitus, Type 2
Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts.
Diphtheria
Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct.
Erythema
Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis.
Eye Diseases
Purification of Recombinant Human Tyrosinase from Insect Larvae Infected with the Baculovirus Vector.
Fibrous Dysplasia, Polyostotic
Activating mutation of GS alpha in McCune-Albright syndrome causes skin pigmentation by tyrosinase gene activation on affected melanocytes.
Fowlpox
Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma.
Fusariosis
[Conjugation resistance to Fusarium graminearum Schwabe with multiple molecular forms of some enzymes in winter wheat]
Genetic Diseases, Inborn
A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China.
Genetic Diseases, Inborn
Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery.
Glaucoma
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.
Glaucoma
Of mice and men: tyrosinase modification of congenital glaucoma in mice but not in humans.
Glioblastoma
Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Ralpha2, gp100 and TRP-2 for immunotherapy.
Glioblastoma
Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.
Glioblastoma
Role of neurofibromin in modulation of expression of the tyrosinase-related protein 2 gene.
Glioma
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Glioma
Tyrosinase transfection produces melanin synthesis and growth retardation in glioma cells.
Gout
Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.
Graves Disease
Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay.
Hamartoma
Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.
Heart Failure
'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions.
Heart Failure
Electrochemically reduced graphene and iridium oxide nanoparticles for inhibition-based angiotensin-converting enzyme inhibitor detection.
Hemangiosarcoma
Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series.
Hepatic Encephalopathy
The effects of hemoperfusion using coated charcoal or tyrosinase artificial cells on middle molecules and tyrosine in brain and serum of hepatic coma rats.
Hepatitis C
In Vitro Antiviral Activity of Tyrosinase from Mushroom Agaricus bisporus against Hepatitis C Virus.
Hepatolenticular Degeneration
Inhibition kinetics of mushroom tyrosinase by copper-chelating ammonium tetrathiomolybdate.
Hereditary Sensory and Autonomic Neuropathies
[Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications: case report].
Hermanski-Pudlak Syndrome
Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA.
Hermanski-Pudlak Syndrome
Iron upregulates melanogenesis in cultured retinal pigment epithelial cells.
Hermanski-Pudlak Syndrome
Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
Hermanski-Pudlak Syndrome
Role of the ubiquitin proteasome system in regulating skin pigmentation.
Herpes Simplex
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
Herpes Simplex
Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.
Herpes Simplex
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Herpes Simplex
[In vitro studies of the antiviral activity of enzymatically oxidized o-diphenolic compounds against herpes simplex virus type 1 and 2 (author's transl)]
Histiocytoma
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
Histiocytoma, Benign Fibrous
The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression.
Histiocytoma, Benign Fibrous
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Homocystinuria
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Hutchinson's Melanotic Freckle
A possible mechanism of action for azelaic acid in the human epidermis.
Hutchinson's Melanotic Freckle
Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts.
Hutchinson's Melanotic Freckle
Analytical, ultrastructural, autoradiographic and biochemical studies on [3H]dicarboxylic acid added to cultures of melanoma cells.
Hutchinson's Melanotic Freckle
Effect of dicarboxylic acids on normal human melanocytes in dispersed tissue culture.
Hutchinson's Melanotic Freckle
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma.
Hyperpigmentation
(E)-2-Cyano-3-(substituted phenyl)acrylamide analogs as potent inhibitors of tyrosinase: A linear ?-phenyl-?,?-unsaturated carbonyl scaffold.
Hyperpigmentation
2-(3, 4-dihydroxybenzylidene)malononitrile as a novel anti-melanogenic compound.
Hyperpigmentation
2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism.
Hyperpigmentation
3-hydroxycoumarin loaded vesicles for recombinant human tyrosinase inhibition in topical applications.
Hyperpigmentation
4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
Hyperpigmentation
A double-blind, placebo-controlled randomized trial of skin-lightening cream containing lycopene and wheat bran extract on melasma.
Hyperpigmentation
A new type of tyrosinase inhibitors from natural products as potential treatments for hyperpigmentation.
Hyperpigmentation
A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.
Hyperpigmentation
A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression.
Hyperpigmentation
A novel method for explaining the product inhibition mechanisms via molecular docking: inhibition studies for tyrosinase from Agaricus bisporus.
Hyperpigmentation
A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions.
Hyperpigmentation
Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey.
Hyperpigmentation
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Hyperpigmentation
Aloin, cinnamic acid and sophorcarpidine are potent inhibitors of tyrosinase.
Hyperpigmentation
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Hyperpigmentation
An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies.
Hyperpigmentation
Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation.
Hyperpigmentation
Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract.
Hyperpigmentation
Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
Hyperpigmentation
Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
Hyperpigmentation
Anti-tyrosinase activity of South African Aloe species and isolated compounds plicataloside and aloesin.
Hyperpigmentation
Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications.
Hyperpigmentation
Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor.
Hyperpigmentation
Biological activity and molecular docking studies of curcumin-related ?,?-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors.
Hyperpigmentation
Biological evaluation of Keggin-type polyoxometalates on tyrosinase: Kinetics and molecular modeling.
Hyperpigmentation
Caffeic Acid Phenethyl Ester Inhibits Alpha-Melanocyte Stimulating Hormone-Induced Melanin Synthesis through Suppressing Transactivation Activity of Microphthalmia-Associated Transcription Factor.
Hyperpigmentation
Carbazole and hydrazone derivatives as new competitive inhibitors of tyrosinase: Experimental clues to binuclear copper active site binding.
Hyperpigmentation
Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.
Hyperpigmentation
Characterization of Caffeoylquinic Acids from Lepisorus thunbergianus and Their Melanogenesis Inhibitory Activity.
Hyperpigmentation
Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase.
Hyperpigmentation
Chicken Egg White-Advancing from Food to Skin Health Therapy: Optimization of Hydrolysis Condition and Identification of Tyrosinase Inhibitor Peptides.
Hyperpigmentation
Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterization and Evaluation of the In Vitro Tyrosinase Inhibition.
Hyperpigmentation
Computational strategies towards developing novel antimelanogenic agents.
Hyperpigmentation
Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.
Hyperpigmentation
Design, Synthesis and Biological Evaluation of Oxindole-Based Chalcones as Small-Molecule Inhibitors of Melanogenic Tyrosinase.
Hyperpigmentation
Design, synthesis of Cinnamyl-paeonol derivatives with 1, 3-Dioxypropyl as link arm and screening of tyrosinase inhibition activity in vitro.
Hyperpigmentation
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
Hyperpigmentation
Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment.
Hyperpigmentation
Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.
Hyperpigmentation
Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling.
Hyperpigmentation
Downregulation of melanin synthesis by haginin a and its application to in vivo lightening model.
Hyperpigmentation
Effect of chrysin omega-3 and 6 fatty acid esters on mushroom tyrosinase activity, stability, and structure.
Hyperpigmentation
Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.
Hyperpigmentation
Effect of saucerneol D on melanin production in cAMP-elevated melanocytes.
Hyperpigmentation
Effect of Sucrier Banana Peel Extracts on Inhibition of Melanogenesis through the ERK Signaling Pathway.
Hyperpigmentation
Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol).
Hyperpigmentation
Essential oils composition of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae - Periplocoideae).
Hyperpigmentation
Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways.
Hyperpigmentation
Evaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects.
Hyperpigmentation
Evaluation of Antimelanogenic Activity and Mechanism of Galangin in Silico and in Vivo.
Hyperpigmentation
Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico.
Hyperpigmentation
Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies.
Hyperpigmentation
Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression.
Hyperpigmentation
Flower extracts from Paeonia decomposita and Paeonia ostii inhibit melanin synthesis via cAMP-CREB-associated melanogenesis signaling pathways in murine B16 melanoma cells.
Hyperpigmentation
Hemocyanin-derived phenoloxidase activity: a contributing factor to hyperpigmentation in Nephrops norvegicus.
Hyperpigmentation
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.
Hyperpigmentation
Hydroquinone Therapy for Post-inflammatory Hyperpigmentation Secondary to Acne: Not Just Prescribable by Dermatologists.
Hyperpigmentation
Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.
Hyperpigmentation
Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter.
Hyperpigmentation
Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase.
Hyperpigmentation
Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation.
Hyperpigmentation
Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase.
Hyperpigmentation
In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds.
Hyperpigmentation
In vitro anti-melanogenic effects of chimeric compounds, 2-(substituted benzylidene)-1,3-indanedione derivatives with a ?-phenyl-?, ? -unsaturated dicarbonyl scaffold.
Hyperpigmentation
Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe.
Hyperpigmentation
Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation.
Hyperpigmentation
Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase.
Hyperpigmentation
Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling.
Hyperpigmentation
Inhibitory effect of Cinnamomum osmophloeum Kanehira ethanol extracts on melanin synthesis via repression of tyrosinase expression.
Hyperpigmentation
Inhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis.
Hyperpigmentation
Inhibitory effect of phthalic Acid on tyrosinase: the mixed-type inhibition and docking simulations.
Hyperpigmentation
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Hyperpigmentation
Inhibitory effects of calycosin isolated from the root of Astragalus membranaceus on melanin biosynthesis.
Hyperpigmentation
Inhibitory Effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on Mushroom Tyrosinase.
Hyperpigmentation
Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity.
Hyperpigmentation
Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin.
Hyperpigmentation
Inhibitory kinetics of paeonol on the activity of mushroom tyrosinase oxidizing L-dopa.
Hyperpigmentation
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.
Hyperpigmentation
Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin-1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation.
Hyperpigmentation
Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts.
Hyperpigmentation
Melanocytes sense blue light and regulate pigmentation through the Opsin3.
Hyperpigmentation
Melanogenesis-Promoting Effects of Rhynchosia nulubilis and Rhynchosia volubilis Ethanol Extracts in Melan-a Cells.
Hyperpigmentation
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Hyperpigmentation
Modifying effects of carboxyl group on the interaction of recombinant S100A8/A9 complex with tyrosinase.
Hyperpigmentation
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Hyperpigmentation
Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies.
Hyperpigmentation
Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells.
Hyperpigmentation
Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties.
Hyperpigmentation
Oleoylethanolamide inhibits ?-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells.
Hyperpigmentation
Origanum essential oils reduce the level of melanin in B16-F1 melanocytes.
Hyperpigmentation
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
Hyperpigmentation
p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects.
Hyperpigmentation
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Hyperpigmentation
Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment.
Hyperpigmentation
Phlorotannins with Potential Anti-tyrosinase and Antioxidant Activity Isolated from the Marine Seaweed Ecklonia stolonifera.
Hyperpigmentation
Phytochemical Investigations and In Vitro Bioactivity Screening on Melia azedarach L. Leaves Extract from Nepal.
Hyperpigmentation
Plants from Brazilian Cerrado with potent tyrosinase inhibitory activity.
Hyperpigmentation
Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color.
Hyperpigmentation
Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography.
Hyperpigmentation
Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism.
Hyperpigmentation
Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression.
Hyperpigmentation
Screening of Chinese herbal medicines for antityrosinase activity in a cell free system and B16 cells.
Hyperpigmentation
Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.
Hyperpigmentation
Screening the dermatological potential of plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase.
Hyperpigmentation
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.
Hyperpigmentation
Short-Sequence Oligopeptides with Inhibitory Activity against Mushroom and Human Tyrosinase.
Hyperpigmentation
Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis.
Hyperpigmentation
Supravenous hyperpigmentation, transverse leuconychia and transverse melanonychia after chemotherapy for Hodgkin's disease.
Hyperpigmentation
Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells.
Hyperpigmentation
Synthesis of methyl ether analogues of sildenafil (Viagra) possessing tyrosinase inhibitory potential.
Hyperpigmentation
Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.
Hyperpigmentation
The degrees of UVB-induced erythema and pigmentation correlate linearly and are reduced in a parallel manner by topical anti-inflammatory agents.
Hyperpigmentation
Topical retinoic acid for photoaging: clinical response and underlying mechanisms.
Hyperpigmentation
Torilin from Torilis japonica Inhibits Melanin Production in alpha-Melanocyte Stimulating Hormone-Activated B16 Melanoma Cells.
Hyperpigmentation
Triazine-based tyrosinase inhibitors identified by chemical genetic screening.
Hyperpigmentation
Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.
Hyperpigmentation
Tyrosinase inhibitor-loaded microsponge drug delivery system: new approach for hyperpigmentation disorders.
Hyperpigmentation
Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.
Hyperpigmentation
Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous.
Hyperpigmentation
UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes.
Hyperpigmentation
[Factors affecting melanogenesis and methods used for identification of pigmentation disorders]
Hypersensitivity
Effect of urea-extracted sericin on melanogenesis: potential applications in post-inflammatory hyperpigmentation.
Hypohidrosis
[Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications: case report].
Hypopigmentation
A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells.
Hypopigmentation
A splicing mutation of the tyrosinase gene causes yellow oculocutaneous albinism in a Japanese patient with a pigmented phenotype.
Hypopigmentation
A tyrosinase gene missense mutation in temperature-sensitive type I oculocutaneous albinism. A human homologue to the Siamese cat and the Himalayan mouse.
Hypopigmentation
AAV-mediated Tyrosinase Gene Transfer Restores Melanogenesis and Retinal Function in a Model of Oculo-cutaneous Albinism Type I (OCA1).
Hypopigmentation
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Hypopigmentation
Clinical and cellular characterization of Hermansky-Pudlak Syndrome Type-6.
Hypopigmentation
Comparative Depigmentation Effects of Resveratrol and Its Two Methyl Analogues in ?-Melanocyte Stimulating Hormone-Triggered B16/F10 Murine Melanoma Cells.
Hypopigmentation
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Hypopigmentation
Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation.
Hypopigmentation
Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo.
Hypopigmentation
Effects of a non-cyclodextrin cyclic carbohydrate on mouse melanoma cells: Characterization of a new type of hypopigmenting sugar.
Hypopigmentation
Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes
Hypopigmentation
Evaluation of hypopigmentation in embryonic zebrafish induced by emerging disinfection byproduct, 3, 5-di-I-tyrosylalanine.
Hypopigmentation
Homozygosity Mapping and Whole-Exome Sequencing to Detect SLC45A2 and G6PC3 Mutations in a Single Patient with Oculocutaneous Albinism and Neutropenia.
Hypopigmentation
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects.
Hypopigmentation
Inhibitory effects of 16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid (Corchorifatty acid B) isolated from Melissa officinalis Linné on melanogenesis.
Hypopigmentation
Lupenone from Erica multiflora Leaf Extract Stimulates Melanogenesis in B16 Murine Melanoma Cells through the Inhibition of ERK1/2 Activation.
Hypopigmentation
Melanogenic effect of purified mushroom tyrosinase on B16F10 Melanocytes: A Phase Contrast and Immunofluorescence Microscopic Study.
Hypopigmentation
Nobiletin, a Polymethoxy Flavonoid, Reduced Endothelin-1 Plus SCF-Induced Pigmentation in Human Melanocytes.
Hypopigmentation
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Hypopigmentation
p-Coumaric acid inhibition of CREB phosphorylation reduces cellular melanogenesis
Hypopigmentation
Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells.
Hypopigmentation
Prenatal diagnosis of oculocutaneous albinism type I: review and personal experience.
Hypopigmentation
Quercetin-3-O-?-d-glucopyranosyl-(1 ? 6)-?-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.
Hypopigmentation
Recent Updates On Melanocyte Biology And The Use Of Promising Bioactive Compounds For The Treatment Of Hypopigmentary Disorders: A Review.
Hypopigmentation
The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis.
Hypopigmentation
The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.
Hypopigmentation
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Hypopigmentation
[Menkes syndrome. An unusual pigmentation anomaly in a mother and three sisters]
Infections
Activation of tyrosinase in Agaricus bisporus strains following infection by Pseudomonas tolaasii or treatment with a tolaasin-containing preparation.
Infections
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease.
Infections
Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.
Infections
In Vitro Effects of Streptomyces tyrosinase on the Egg and Adult Worm of Toxocara vitulorum.
Infections
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.
Infections
Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes.
Infections
Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line.
Infections
Systemic acquired resistance in Cavendish banana induced by infection with an incompatible strain of Fusarium oxysporum f. sp. cubense.
Infections
Testing in mice the hypothesis that melanin is protective in malaria infections.
Infections
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
Infections
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport.
Infections
[Ocular infiltrating CD 4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens]
Influenza, Human
Analysis of the T cell response to tumor and viral peptide antigens by an IFNgamma-ELISPOT assay.
Influenza, Human
Characterization and pharmacological potential of Lactobacillus sakei 1I1 isolated from fresh water fish Zacco koreanus.
Influenza, Human
Characterization of antigen-specific CD8+ T lymphocyte responses in skin and peripheral blood following intradermal peptide vaccination.
Influenza, Human
Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines.
Influenza, Human
Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).
Influenza, Human
Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptides in vivo: implications for tumor vaccines with melanoma-associated antigens.
Influenza, Human
Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon.
Influenza, Human
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
Influenza, Human
In vitro expansion of Ag-specific T cells by HLA-A*0201-transfected K562 cells for immune monitoring.
Influenza, Human
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
Influenza, Human
Scalable expansion of potent genetically modified human langerhans cells in a closed system for clinical applications.
Influenza, Human
Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma.
Influenza, Human
The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand.
Influenza, Human
The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha spots in response to peptide antigens.
Intellectual Disability
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Iris Diseases
Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma.
Keratosis, Actinic
Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis.
Keratosis, Actinic
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Lentigo
Hypopigmenting Activity of Bisabolangelone Isolated from Angelica koreana Maxim. in alpha-Melanocyte Stimulating Hormone-Activated B16 or Melan-a Cells.
Lentigo
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.
Lentigo
The Anti-melanogenesis Activities of Some Selected Red Macroalgae from Northern Coasts of the Persian Gulf.
Lentigo
The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis.
Leukemia
Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.
Leukemia
Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma.
Leukemia
gamma-L-Glutaminyl-4-hydroxybenzene, an inducer of cryptobiosis in Agaricus bisporus and a source of specific metabolic inhibitors for melanogenic cells.
Leukemia
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Leukemia
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lichenoid drug eruption due to imatinib mesylate.
Leukemia, Myeloid
Antioxidant, Anti-tyrosinase, Anti-?-amylase, and Cytotoxic Potentials of the Invasive Weed Andropogon virginicus.
Leukemia, T-Cell
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
Liposarcoma
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Liver Failure
Tyrosinase immobilized within artificial cells for detoxification in liver failure: I. preparation and in vitro studies.
Liver Failure
Tyrosinase immobilized within artificial cells for detoxification in liver failure: II. In vivo studies in fulminant hepatic failure rats.
Liver Failure, Acute
Tyrosinase immobilized within artificial cells for detoxification in liver failure: II. In vivo studies in fulminant hepatic failure rats.
Liver Neoplasms, Experimental
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Lung Diseases
Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease.
Lymphatic Metastasis
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Lymphatic Metastasis
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Lymphatic Metastasis
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Lymphatic Metastasis
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Lymphatic Metastasis
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
Lymphatic Metastasis
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
Lymphatic Metastasis
[Detection of tyrosinase mRNA using reverse transcription/polymerase chain reaction with fine needle punctures of melanoma metastases]
Lymphoma
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
Lymphoma
Reliability of PCR-based detection of occult tumour cells: lessons from real-time RT-PCR.
Malaria, Cerebral
Testing in mice the hypothesis that melanin is protective in malaria infections.
Melanoma
(2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells.
Melanoma
(Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene)thiazol-4(5H)-one Derivatives as Novel Tyrosinase Inhibitors.
Melanoma
3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells.
Melanoma
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
Melanoma
4-n-butylresorcinol enhances proteolytic degradation of tyrosinase in B16F10 melanoma cells.
Melanoma
4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.
Melanoma
4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma.
Melanoma
7,8-Dimethoxycoumarin stimulates melanogenesis via MAPKs mediated MITF upregulation.
Melanoma
A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.
Melanoma
A chelating derivative of alpha-melanocyte stimulating hormone as a potential imaging agent for malignant melanoma.
Melanoma
A chemical compound from fruit extract of Juglans mandshurica inhibits melanogenesis through p-ERK-associated MITF degradation.
Melanoma
A cis-acting element involved in mouse tyrosinase gene expression and partial purification of its binding protein.
Melanoma
A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation.
Melanoma
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
Melanoma
A Coreceptor-Independent Transgenic Human TCR Mediates Anti-Tumor and Anti-Self Immunity in Mice.
Melanoma
A dual mechanism of 4-hydroxy-5-methyl-3[2H]-furanone inhibiting cellular melanogenesis.
Melanoma
A Fluorescent Probe for Early Detection of Melanoma and Its Metastasis by Specifically Imaging Tyrosinase Activity in a Mouse Model.
Melanoma
A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity.
Melanoma
A histochemical autoradiographic method for demonstration of tyrosinase in human melanocytes, nevi and malignant melanoma.
Melanoma
A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.
Melanoma
A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway.
Melanoma
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
Melanoma
A new standardized absolute quantitative RT-PCR method for detection of tyrosinase mRNAs in melanoma patients: technical and operative instructions.
Melanoma
A new tyrosinase epitope recognized in the HLA-B*4002 context by CTL from melanoma patients.
Melanoma
A New Tyrosinase Inhibitor from the Red Alga Symphyocladia latiuscula (Harvey) Yamada (Rhodomelaceae).
Melanoma
A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells.
Melanoma
A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells.
Melanoma
A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death.
Melanoma
A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells.
Melanoma
A novel radiopharmaceutical for detection of malignant melanoma, based on melanin formation: 3-iodo-4-hydroxyphenyl-L-cysteine.
Melanoma
A panel immunoblot using co-incubated monoclonal antibodies for identification of melanoma cells.
Melanoma
A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).
Melanoma
A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.
Melanoma
A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes.
Melanoma
A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in ?-MSH and IBMX-Induced B16F10 Melanoma Cells.
Melanoma
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
Melanoma
A safe, effective in vivo gene therapy for melanoma using tyrosinase promoter-driven cytosine deaminase gene.
Melanoma
A Strategy Based on the Enzyme-Catalyzed Polymerization Reaction of Asp-Phe-Tyr Tripeptide for Cancer Immunotherapy.
Melanoma
A survey of the humoral immune response of cancer patients to a panel of human tumor antigens.
Melanoma
A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component.
Melanoma
A two-photon fluorescent probe for intracellular detection of tyrosinase activity.
Melanoma
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes.
Melanoma
A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes.
Melanoma
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.
Melanoma
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Melanoma
Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA.
Melanoma
Accurate molecular detection of melanoma nodal metastases: an assessment of multimarker assay specificity, sensitivity, and detection rate.
Melanoma
Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation.
Melanoma
ACTH1-4 potentiates alpha-MSH-induced melanophore dispersion and excessive grooming.
Melanoma
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
Melanoma
Activation of melanogenesis by vacuolar type H(+)-ATPase inhibitors in amelanotic, tyrosinase positive human and mouse melanoma cells.
Melanoma
Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system.
Melanoma
Activation of MITF by Argan Oil Leads to the Inhibition of the Tyrosinase and Dopachrome Tautomerase Expressions in B16 Murine Melanoma Cells.
Melanoma
Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells.
Melanoma
Activation of tyrosinase in microsomes and melanosomes from B16 and Harding-Passey melanomas.
Melanoma
Activation of tyrosinase reduces the cytotoxic effects of the superoxide anion in B16 mouse melanoma cells.
Melanoma
Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts.
Melanoma
Acute effects of two melanocytolytic agents, hydroquinone and beta-mercaptoethanolamine, upon tyrosinase activity and cyclic nucleotide levels in murine melanomas.
Melanoma
Additive Effect of a Combination of Artocarpus lakoocha and Glycyrrhiza glabra Extracts on Tyrosinase Inhibition in Melanoma B16 Cells.
Melanoma
Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma.
Melanoma
Adenovirus MART-1-engineered Autologous Dendritic Cell Vaccine for Metastatic Melanoma.
Melanoma
Adjuvant dendritic cell vaccination induces tumor-specific immune responses in the majority of stage III melanoma patients.
Melanoma
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Melanoma
Agouti protein inhibits growth of B16 melanoma cells in vitro by acting through melanocortin receptors.
Melanoma
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Melanoma
Allo-restricted CTLs generated by coculturing of PBLs and autologous monocytes loaded with allogeneic peptide/HLA/IgG1-Fc fusion protein.
Melanoma
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Melanoma
Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C.
Melanoma
alpha-Melanocyte-stimulating hormone binding and biological activity in a human melanoma cell line.
Melanoma
Alpha-melanocyte-stimulating hormone regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures.
Melanoma
Alpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome tautomerase in B16/F10 mouse melanoma cells.
Melanoma
Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity.
Melanoma
Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis.
Melanoma
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands.
Melanoma
Alternative splicing of the tyrosinase gene transcript in normal human melanocytes and lymphocytes.
Melanoma
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Melanoma
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
Melanoma
An antigenic peptide produced by reverse splicing and double asparagine deamidation.
Melanoma
An aqueous extract of Limoniastrum guyonianum gall induces anti-tumor effects in melanoma-injected mice via modulation of the immune response.
Melanoma
An ester extract of Cochinchina momordica seeds induces differentiation of melanoma B16 F1 cells via MAPKs signaling.
Melanoma
An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.
Melanoma
An improved and combined reverse transcription-polymerase chain reaction assay for reliable detection of metastatic melanoma cells in peripheral blood.
Melanoma
An N-glycosylated tyrosinase epitope associates with newly synthesized MHC class I molecules in melanoma cells.
Melanoma
Analysis of carbohydrate properties essential for melanogenesis in tyrosinases of cultured malignant melanoma cells by differential carbohydrate processing inhibition.
Melanoma
Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy.
Melanoma
Analysis of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction for tyrosinase and MART-1 after mononuclear cell collection with cell preparation tubes: a comparison with the whole blood guanidinium isothiocyanate RNA isolation method.
Melanoma
Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
Melanoma
Analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates.
Melanoma
Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.
Melanoma
Analysis of the T cell response to tumor and viral peptide antigens by an IFNgamma-ELISPOT assay.
Melanoma
Analytical, ultrastructural, autoradiographic and biochemical studies on [3H]dicarboxylic acid added to cultures of melanoma cells.
Melanoma
Anionic polysaccharide production and tyrosinase activation in cultured human melanoma cells.
Melanoma
Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor.
Melanoma
Anti melanogenic effect of Croton roxburghii and Croton sublyratus leaves in ?-MSH stimulated B16F10?cells.
Melanoma
Anti-inflammatory and anti-melanogenesis activities of sulfated polysaccharides isolated from Hizikia fusiforme: Short communication.
Melanoma
Anti-melanization effects and inhibitory kinetics of tyrosinase of bird's nest fern (Asplenium australasicum) frond extracts on melanoma and human skin.
Melanoma
Anti-melanogenesis potential of a new series of Morita-Baylis-Hillman adducts in B16F10 melanoma cell line.
Melanoma
Anti-melanogenesis properties of condensed tannins from Vigna angularis seeds with potent antioxidant and DNA damage protection activities.
Melanoma
Anti-Melanogenic Activity and Cytotoxicity of Pistacia vera Hull on Human Melanoma SKMEL-3 Cells.
Melanoma
Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells.
Melanoma
Anti-melanogenic and anti-oxidant activities of ethanol extract of Kummerowia striata: Kummerowia striata regulate anti-melanogenic activity through down-regulation of TRP-1, TRP-2 and MITF expression.
Melanoma
Anti-melanogenic effect of (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione, a novel tyrosinase inhibitor.
Melanoma
Anti-melanogenic effects of Aster spathulifolius extract in UVB-exposed C57BL/6J mice and B16F10 melanoma cells through the regulation of MAPK/ERK and AKT/GSK3? signalling.
Melanoma
Anti-melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin.
Melanoma
Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
Melanoma
Anti-Melanogenic Mechanism of Tetrahydrocurcumin and Enhancing Its Topical Delivery Efficacy Using a Lecithin-Based Nanoemulsion.
Melanoma
Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
Melanoma
Anti-melanoma cytotoxic T lymphocytes (CTL) recognize numerous antigenic peptides having 'self' sequences: autoimmune nature of the anti-melanoma CTL response.
Melanoma
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Melanoma
Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet.
Melanoma
Anti-oxidative, anti-inflammatory and whitening effects of phenolic compounds from Bambusae Caulis in Liquamen.
Melanoma
Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules.
Melanoma
Antibacterial, Antioxidant and Melanogenesis Inhibitory Activity of Auraptene, a Coumarin from Ferula szowitsiana Root.
Melanoma
Antimelanogenesis and Anti-Inflammatory Activity of Selected Culinary-Medicinal Mushrooms.
Melanoma
Antimelanogenesis Effects of Fungal Exopolysaccharides Prepared from Submerged Culture of Fomitopsis castanea Mycelia.
Melanoma
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Melanoma
Antimelanoma effect of 4-S-cysteaminylcatechol, an activated form of 4-S-cysteaminylphenol.
Melanoma
Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives.
Melanoma
Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract.
Melanoma
Antioxidative properties and inhibitory effect of Bifidobacterium adolescentis on melanogenesis
Melanoma
Antioxidative properties and inhibitory effect of Bifidobacterium adolescentis on melanogenesis.
Melanoma
Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells.
Melanoma
Antitumoral, antioxidant, and antimelanogenesis potencies of Hawthorn, a potential natural agent in the treatment of melanoma.
Melanoma
Application of paclitaxel in low non-cytotoxic doses supports vaccination with melanoma antigens in normal mice.
Melanoma
Aqueous fraction from Cuscuta japonica seed suppresses melanin synthesis through inhibition of the p38 mitogen-activated protein kinase signaling pathway in B16F10 cells.
Melanoma
Aromatic-turmerone inhibits ?-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways.
Melanoma
Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase.
Melanoma
Augmentation of melanoma-specific gene expression using a tandem melanocyte-specific enhancer results in increased cytotoxicity of the purine nucleoside phosphorylase gene in melanoma.
Melanoma
Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma.
Melanoma
Autologous human dendriphages pulsed with synthetic or natural tumor peptides elicit tumor-specific CTLs in vitro.
Melanoma
Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial.
Melanoma
Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF.
Melanoma
Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.
Melanoma
Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells.
Melanoma
BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM.
Melanoma
Bioactivation of luteolin by tyrosinase selectively inhibits glutathione S-transferase.
Melanoma
Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation.
Melanoma
Biochemical characterization of the melanogenic system in the eye of adult rodents.
Melanoma
Biochemical characterization of three hamster melanoma variants--I. Tyrosinase activity and melanin content.
Melanoma
Biochemical characterization of tyrosinase inhibitors using tyrosinase binding affinity chromatography.
Melanoma
Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines.
Melanoma
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Melanoma
Biochemical mechanism of caffeic acid phenylethyl ester (CAPE) selective toxicity towards melanoma cell lines.
Melanoma
Biological assays of BF2-naphthyridine compounds: Tyrosinase and acetylcholinesterase activity, CT-DNA and HSA binding property evaluations.
Melanoma
Bleomycin enhances the tyrosinase activity of human malignant melanoma cells in culture.
Melanoma
Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control.
Melanoma
Bone marrow contains melanoma-reactive CD8+ effector T cells and, compared with peripheral blood, enriched numbers of melanoma-reactive CD8+ memory T cells.
Melanoma
Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.
Melanoma
Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanoma.
Melanoma
Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase.
Melanoma
Bromodeoxyuridine- and cyclic AMP-mediated regulation of tyrosinase in Syrian hamster melanoma cells.
Melanoma
Bystander killing of melanoma cells using the human tyrosinase promoter to express the Escherichia coli purine nucleoside phosphorylase gene.
Melanoma
Caffeic Acid Phenethyl Ester Assisted by Reversible Electroporation-In Vitro Study on Human Melanoma Cells.
Melanoma
Capsaicin reverses the inhibitory effect of licochalcone A/?-Arbutin on tyrosinase expression in b16 mouse melanoma cells.
Melanoma
Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development.
Melanoma
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Melanoma
CD4+ T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase.
Melanoma
CD40 ligand and lipopolysaccharide enhance the in vitro generation of melanoma-reactive T-cells.
Melanoma
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.
Melanoma
CD8-independent tumor cell recognition is a property of the T cell receptor and not the T cell.
Melanoma
Cell adhesion regulates melanoma specific differentiation and interactions with the 3' region of the tyrosinase gene.
Melanoma
Cellular sialic acid level and phenotypic expression in B16 melanoma cells: comparison of spontaneous variations and bromodeoxyuridine- and theophylline-induced changes.
Melanoma
Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression.
Melanoma
Changes in the presence of multiple markers of circulating melanoma cells correlate with clinical outcome in patients with melanoma.
Melanoma
Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid (MHY384).
Melanoma
Characterization of Caffeoylquinic Acids from Lepisorus thunbergianus and Their Melanogenesis Inhibitory Activity.
Melanoma
Characterization of chemical constituents with their antioxidant and anti-melanogenesis activities from the roots of Ampelopsis japonica.
Melanoma
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.
Melanoma
Characterization of gene regulatory elements for selective gene expression in human melanoma cells.
Melanoma
Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase.
Melanoma
Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology.
Melanoma
Characterization of seven human melanoma cell lines: melanogenesis and secretion of plasminogen activators.
Melanoma
Characterization of structural properties for morphological differentiation of melanosomes: I. Purification of tyrosinase by tyrosine affinity chromatography and its characterization in B16 and Harding Passey melanomas.
Melanoma
Characterization of the effects of different retinoids on the growth and differentiation of a human melanoma cell line and selected subclones.
Melanoma
Chemical and histochemical analyses of tyrosinase activity in melanoma and related lesions.
Melanoma
Chemical Composition of Miscanthus sinensis var. purpurascens Flower Absolute and Its Beneficial Effects on Skin Wound Healing and Melanogenesis-Related Cell Activities.
Melanoma
Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis.
Melanoma
Chloroform extract from Moricandia arvensis inhibits growth of B16-F0 melanoma cells and promotes differentiation in vitro.
Melanoma
Chronic stress induces fur color change from dark to brown by decreasing follicle melanocytes and tyrosinase activity in female C57BL/6 mice.
Melanoma
Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis.
Melanoma
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Melanoma
Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.
Melanoma
Circulating tyrosinase and MART-1 mRNA does not independently predict relapse or survival in patients with AJCC stage I-II melanoma.
Melanoma
Citrus flavanone naringenin enhances melanogenesis through the activation of Wnt/?-catenin signalling in mouse melanoma cells.
Melanoma
Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells.
Melanoma
Clinical protocol. Immunization of patients with malignant melanoma with autologous CD34(+) cell-derived dendritic cells transduced ex vivo with a recombinant replication-deficient vaccinia vector encoding the human tyrosinase gene: a phase I trial.
Melanoma
Clinical significance of sequential tyrosinase expression in the peripheral blood of disease-free melanoma patients: a review of literature data.
Melanoma
Clinical significance of the molecular detection of melanoma cells circulating in the peripheral blood in melanoma patients.
Melanoma
Clinical value of combined determination of plasma L-DOPA/tyrosine ratio, S100B, MIA and LDH in melanoma.
Melanoma
Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.
Melanoma
Clonal expansion of Melan A-specific cytotoxic T lymphocytes in a melanoma patient responding to continued immunization with melanoma-associated peptides.
Melanoma
Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.
Melanoma
Co-regulation of melanin precursors and tyrosinase in human pigment cells: roles of cysteine and glutathione.
Melanoma
Combination and efficiency: preparation of dissolving microneedles array loaded with two active ingredients and its anti-pigmentation effects on guinea pigs.
Melanoma
Combining adenoviral oncolysis with temozolomide improves cell killing of melanoma cells.
Melanoma
Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.
Melanoma
Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan-A, and gp100 in metastatic melanoma lesions: implications for immunotherapy.
Melanoma
Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells.
Melanoma
Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.
Melanoma
Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.
Melanoma
Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in cloudman S91 melanoma cells after ultraviolet-irradiation.
Melanoma
Comparative study of tyrosinases from different sources: relationship between halide inhibition and the enzyme active site.
Melanoma
Comparison between three molecular methods for detection of blood melanoma tyrosinase mRNA. Correlation with melanoma stages and S100B, LDH, NSE biochemical markers.
Melanoma
Comparison of antiaging, anti-melanogenesis effects, and active components of Raspberry (Rubus occidentalis L.) extracts according to maturity.
Melanoma
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations.
Melanoma
Comparison of immunohistochemical labelling of melanocyte differentiation antibodies melan-A, tyrosinase and HMB 45 with NKIC3 and S100 protein in the evaluation of benign naevi and malignant melanoma.
Melanoma
Comparison of in vitro cytotoxicity of N-acetyl and N-propionyl derivatives of phenolic thioether amines in melanoma and neuroblastoma cells and the relationship to tyrosinase and tyrosine hydroxylase enzyme activity.
Melanoma
Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells.
Melanoma
Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles.
Melanoma
Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis.
Melanoma
Concordant loss of melanoma differentiation antigens in synchronous and asynchronous melanoma metastases: implications for immunotherapy.
Melanoma
Conditionally replication-competent adenoviral vectors with enhanced infectivity for use in gene therapy of melanoma.
Melanoma
Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.
Melanoma
Conjugation with Phospholipids as a Modification Increasing Anticancer Activity of Phenolic Acids in Metastatic Melanoma-In Vitro and In Silico Studies.
Melanoma
Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells.
Melanoma
Conversion of particulate tyrosinase to soluble form and to desialylated tyrosinase in human malignant melanoma.
Melanoma
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs.
Melanoma
Correlation between the number of melanosomes, tyrosinase mRNA levels, and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agents.
Melanoma
Correlation of positive RT-PCR for tyrosinase in peripheral blood of malignant melanoma patients with clinical stage, survival and other risk factors.
Melanoma
Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells.
Melanoma
Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells.
Melanoma
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.
Melanoma
CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.
Melanoma
Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells.
Melanoma
Cutaneous malignant melanomas in 57 cats: identification of (amelanotic) signet-ring and balloon cell types and verification of their origin by immunohistochemistry, electron microscopy, and in situ hybridization.
Melanoma
Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma.
Melanoma
Cyclin-dependent kinase 5 regulates proliferation, migration, tyrosinase activity, and melanin production in B16-F10 melanoma cells via the essential regulator p-CREB.
Melanoma
Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both ?-catenin and c-Raf-MEK1-ERK signaling axis.
Melanoma
Cytolytic T cell reactivity against melanoma-associated differentiation antigens in peripheral blood of melanoma patients and healthy individuals.
Melanoma
Cytotoxicity of a selected series of substituted phenols towards cultured melanoma cells.
Melanoma
Decay of hormone responsiveness in mouse melanoma cells in culture as a function of cell density.
Melanoma
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Melanoma
Dedifferentiation of human epidermal melanocytes in vitro by long-term trypsinization.
Melanoma
Definition of anti-tyrosinase MAb T311 linear determinant by proteome-based similarity analysis.
Melanoma
Demonstration of cytoplasmic tyrosinase mRNA in tissue-cultured cells by reverse transcription (RT) in situ polymerase chain reaction (PCR) and RT PCR in situ hybridization.
Melanoma
Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity.
Melanoma
Depigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalent.
Melanoma
Depigmentation of ?-melanocyte-stimulating hormone-treated melanoma cells by ?-mangostin is mediated by selective autophagy.
Melanoma
Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.
Melanoma
Dermoscopy, reflectance confocal microscopy and histopathology of an amelanotic melanoma from an individual heterozygous for MC1R and tyrosinase variant alleles.
Melanoma
Design, synthesis and biological evaluation of hydroxy substituted amino chalcone compounds for antityrosinase activity in B16 cells.
Melanoma
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
Melanoma
Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives.
Melanoma
Design, synthesis, and evaluation of (E)-N-substituted benzylidene-aniline derivatives as tyrosinase inhibitors.
Melanoma
Desmoplastic melanoma: comparison of expression of differentiation antigens and cancer testis antigens.
Melanoma
Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
Melanoma
Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens.
Melanoma
Detection of beta-human chorionic gonadotropin mRNA as a marker for cutaneous malignant melanoma.
Melanoma
Detection of circulating malignant cells by RT-PCR in long-term clinically disease-free I stage melanoma patients.
Melanoma
Detection of circulating melanoma cells by RT-PCR amplification of three different melanocyte-specific mRNAs in a mouse model.
Melanoma
Detection of circulating melanoma cells by specific amplification of tyrosinase complementary DNA is not a reliable tumor marker in melanoma patients: a clinical two-center study.
Melanoma
Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis.
Melanoma
Detection of disseminated melanoma cells by reverse-transcription - polymerase chain reaction.
Melanoma
Detection of early micrometastases in subcutaneous fat of primary malignant melanoma patients by identification of tyrosinase-mRNA.
Melanoma
Detection of melanocytes from uveal melanoma in peripheral blood using the polymerase chain reaction.
Melanoma
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Melanoma
Detection of melanoma cells in peripheral blood stem cell harvests of patients with progressive metastatic malignant melanoma.
Melanoma
Detection of melanoma cells in peripheral blood using reverse transcription polymerase chain reaction assay for tyrosinase mRNA.
Melanoma
Detection of melanoma cells in sentinel lymph nodes by reverse transcriptase-polymerase chain reaction: prognostic significance.
Melanoma
Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription-polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness.
Melanoma
Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.
Melanoma
Detection of melanoma micrometastasis in sentinel nodes by reverse transcription-polymerase chain reaction correlates with tumor thickness and is predictive of micrometastatic disease in the lymph node basin.
Melanoma
Detection of micrometastasis in sentinel lymph nodes of patients with primary cutaneous melanoma.
Melanoma
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Melanoma
Detection of mouse tyrosinase with a monoclonal antibody MAT-1 against human tyrosinase.
Melanoma
Detection of regional melanoma metastases by ultrasound B-scan, cytology or tyrosinase RT-PCR of fine-needle aspirates.
Melanoma
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy.
Melanoma
Detection of submicroscopic lymph node metastases with polymerase chain reaction in patients with malignant melanoma.
Melanoma
Detection of tumor messenger RNA in the serum of patients with malignant melanoma.
Melanoma
Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma.
Melanoma
Detection of tumour cells in the bloodstream of patients with uveal melanoma: influence of surgical manipulation on the dissemination of tumour cells in the bloodstream.
Melanoma
Detection of tyrosinase and tyrosinase-related protein 1 sequences from peripheral blood of melanoma patients using reverse transcription-polymerase chain reaction.
Melanoma
Detection of tyrosinase in living cells using an Enteromorpha Prolifera based fluorescent probe.
Melanoma
Detection of tyrosinase mRNA by an optimised nested RT-PCR in the peripheral blood of patients with advanced malignant melanoma.
Melanoma
Detection of tyrosinase mRNA by reverse transcription-polymerase chain reaction in melanoma sentinel nodes.
Melanoma
Detection of tyrosinase mRNA by RT-PCR in the peripheral blood of patients with advanced metastatic melanoma.
Melanoma
Detection of tyrosinase mRNA in formalin-fixed, paraffin-embedded archival sections of melanoma, using the reverse transcriptase in situ polymerase chain reaction.
Melanoma
Detection of tyrosinase mRNA in melanoma by reverse transcription-PCR and electrochemiluminescence.
Melanoma
Detection of tyrosinase mRNA in the sentinel lymph nodes of melanoma patients is not a predictor of short-term disease recurrence.
Melanoma
Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs.
Melanoma
Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies.
Melanoma
Development of Immunologic Assays to Measure Response in Horses Vaccinated with Xenogeneic Plasmid DNA Encoding Human Tyrosinase
Melanoma
Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma.
Melanoma
Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma.
Melanoma
Development of Tyrosinase Promoter-Based Fluorescent Assay for Screening of Anti-melanogenic Agents.
Melanoma
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma.
Melanoma
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Melanoma
Differential expression of MART-1, tyrosinase, and SM5-1 in primary and metastatic melanoma.
Melanoma
Differential regulation of tyrosinase activity in skin of white and black individuals in vivo by topical retinoic acid.
Melanoma
Differentiation apparently repressed by the nucleus. Rapidly-induced pigmentation of enucleated melanoma cells.
Melanoma
Differentiation-inducing and anti-proliferative activities of lupeol on canine melanoma cells.
Melanoma
Dihydro-1,4-benzothiazine-6,7-dione, the ultimate toxic metabolite of 4-S-cysteaminylphenol and 4-S-cysteaminylcatechol.
Melanoma
Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways.
Melanoma
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
Melanoma
Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients.
Melanoma
Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1.
Melanoma
Diverse expansion potential and heterogeneous avidity in tumor-associated antigen-specific T lymphocytes from primary melanoma patients.
Melanoma
DNp73-induced degradation of tyrosinase links depigmentation with EMT-driven melanoma progression.
Melanoma
Docosahexaenoic acid inhibits melanin synthesis in murine melanoma cells in vitro through increasing tyrosinase degradation.
Melanoma
Does intensive histopathological workup by serial sectioning increase the detection of lymph node micrometastasis in patients with primary cutaneous melanoma?
Melanoma
Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
Melanoma
Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity.
Melanoma
Dormant tumor cells interact with memory CD8+ T cells in RET transgenic mouse melanoma model.
Melanoma
Down-regulation of tyrosinase mRNA levels in melanoma cells by tumor promoters and by insulin.
Melanoma
Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma.
Melanoma
Drying methods influence the physicochemical and functional properties of seed-used pumpkin.
Melanoma
Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers.
Melanoma
Ectopic expression of tyrosinase increases melanin synthesis and cell death following UVB irradiation in fibroblasts from familial atypical multiple mole and melanoma (FAMMM) patients.
Melanoma
Effect of ACTH and corticosterone on melanogenesis and cyclic nucleotide levels in the B-16 melanoma.
Melanoma
Effect of alpha-MSH on the tyrosinase activity and the rate of melanin accumulation of melanoma cells in vitro.
Melanoma
Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells.
Melanoma
Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells.
Melanoma
Effect of dopa-loading on glutathione metabolising enzymes and tyrosinase in relation to 5-S-cysteinyl-dopa genesis in cultured B-16 melanoma cells.
Melanoma
Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells, and retinal epithelial cells.
Melanoma
Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells.
Melanoma
Effect of polysaccharide FMP-1 from Morchella esculenta on melanogenesis in B16F10 cells and zebrafish.
Melanoma
Effect of testosterone on imidazole-induced tyrosinase expression in B16 melanoma cell culture.
Melanoma
Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells.
Melanoma
Effect of theophyllin and isoproterenol on cAMP level in melanotic and amelanotic hamster melanomas.
Melanoma
Effect of thymidine analogs on tyrosinase activity and mRNA accumulation in mouse melanoma cells.
Melanoma
Effect of triamcinolone acetonide on tyrosinase activity in a human melanoma cell line.
Melanoma
Effect of Vetiveria zizanioides essential oil on melanogenesis in melanoma cells: downregulation of tyrosinase expression and suppression of oxidative stress.
Melanoma
Effect on growth and structure of transplantable malignant melanomas of the Syrian golden hamster (Mesocricetus auratus) by depletion of phenylalanine and tyrosine in the diet and by inhibition of tyrosinase. Brief report.
Melanoma
Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells.
Melanoma
Effects of actinomycin D and cycloheximide on the increase in tyrosinase activity of hamster amelanotic melanoma cells in vitro.
Melanoma
Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.
Melanoma
Effects of certain resorcinol derivatives on the tyrosinase activity and the growth of melanoma cells.
Melanoma
Effects of estradiol on estrogen receptor, progesterone receptor, and tyrosinase in hamster melanoma transplanted into athymic mice.
Melanoma
Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides.
Melanoma
Effects of L-glutamine on tyrosinase and gamma-glutamyl transpeptidase of B-16 melanoma cells in culture.
Melanoma
Effects of latanoprost on tyrosinase activity and mitotic index of cultured melanoma lines.
Melanoma
Effects of matsutake mushroom scent compounds on tyrosinase and murine B16-F10 melanoma cells.
Melanoma
Effects of pH and type of sugar in the medium on tyrosinase activity in cultured melanoma cells.
Melanoma
Effects of protein hydrolysate from chicken feather meal on tyrosinase activity and melanin formation in B16F10 murine melanoma cells.
Melanoma
Effects of radix polygoni multiflori components on tyrosinase activity and melanogenesis.
Melanoma
Effects of treatments with alpha-difluoromethylornithine and hyperthermia on the growth and polyamine metabolism of Harding-Passey murine melanoma.
Melanoma
Effects of tyrosinase activity on the cytotoxicity of 3,4-dihydroxybenzylamine and buthionine sulfoximine in human melanoma cells.
Melanoma
Effects of tyrosinase activity on the cytotoxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol in melanoma cells.
Melanoma
Effects of wine phenolics and sorghum tannins on tyrosinase activity and growth of melanoma cells.
Melanoma
Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells.
Melanoma
Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus.
Melanoma
Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus armed with TNF-related apoptosis inducing ligand.
Melanoma
Electrochemical, photoelectrochemical, and piezoelectric analysis of tyrosinase activity by functionalized nanoparticles.
Melanoma
Electrochemistry-Regulated Recyclable SERS Sensor for Sensitive and Selective Detection of Tyrosinase Activity.
Melanoma
Electrophoretic characterization of tyrosinase in the coated vesicles of malignant melanoma.
Melanoma
Electrophoretic profile of tyrosinase treated with neuraminidase in various subcellular fractions from mouse melanoma.
Melanoma
Elucidating the immunological effects of 5-azacytidine treatment in patients with myelodysplastic syndrome and identifying new conditional ligands and T-cell epitopes of relevance in melanoma.
Melanoma
Enhancement of gene expression and melanin production of human tyrosinase gene loaded in elastic cationic niosomes.
Melanoma
Enhancement of pulmonary metastasis formation and gamma-glutamyltranspeptidase activity in B16 melanoma induced by differentiation in vitro.
Melanoma
Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine.
Melanoma
Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells.
Melanoma
Ethyl acetate extract from Panax ginseng C.A. Meyer and its main constituents inhibit ?-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells.
Melanoma
Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes.
Melanoma
Evaluation of CD8(+) T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with tyrosinase peptide.
Melanoma
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Melanoma
Evaluation of melanogenesis in A-375 cells in the presence of DMSO and analysis of pyrolytic profile of isolated melanin.
Melanoma
Evaluation of Novel Chalcone Oximes as Inhibitors of Tyrosinase and Melanin Formation in B16 Cells.
Melanoma
Evaluation of peptide vaccine immunogenicity in draining lymph nodes and peripheral blood of melanoma patients.
Melanoma
Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma.
Melanoma
Evaluation of standard tyrosinase RT-PCR in melanoma patients by the use of the LightCycler system.
Melanoma
Evaluation of the inhibition of mushroom tyrosinase and cellular tyrosinase activities of oxyresveratrol: comparison with mulberroside A.
Melanoma
Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines.
Melanoma
Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico.
Melanoma
Evaluation of the use of tyrosinase-specific and melanA/MART-1-specific reverse transcriptase-coupled--polymerase chain reaction to detect melanoma cells in peripheral blood samples from 299 patients with malignant melanoma.
Melanoma
Evaluation of variants of melanoma-associated antigen genes and mRNA transcripts in melanomas of dogs.
Melanoma
Evidence consistent with the requirement of cresolase activity for suicide inactivation of tyrosinase.
Melanoma
Ex vivo derived primary melanoma cells: implications for immunotherapeutic vaccines.
Melanoma
Examination of regional lymph nodes by sentinel node biopsy and molecular analysis provides new staging facilities in primary cutaneous melanoma.
Melanoma
Exploitation of pigment biosynthesis pathway as a selective chemotherapeutic approach for malignant melanoma.
Melanoma
Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors: Quercetin and the Central Role of p53.
Melanoma
Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma.
Melanoma
Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas.
Melanoma
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Melanoma
Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients.
Melanoma
Expression of melanin-related genes in cultured adult human retinal pigment epithelium and uveal melanoma cells.
Melanoma
Expression of melanocyte differentiation antigens and ki-67 in nodal nevi and comparison of ki-67 expression with metastatic melanoma.
Melanoma
Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa.
Melanoma
Expression of melanoma inhibitory activity in melanoma and nonmelanoma tissue specimens.
Melanoma
Expression of transporter associated with antigen processing 1 and 2 (TAP1/2) in malignant melanoma cell lines.
Melanoma
Expression of tyrosinase, MIA and MART-1 in sentinel lymph nodes of patients with malignant melanoma.
Melanoma
Expression of tyrosinase, TRP-1 and TRP-2 in ultraviolet-irradiated human melanomas and melanocytes: TRP-2 protects melanoma cells from ultraviolet B induced apoptosis.
Melanoma
Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma.
Melanoma
Extracellular matrix modulates the function of human melanocytes but not melanoma cells.
Melanoma
Extracts of Morus nigra L. Leaves Standardized in Chlorogenic Acid, Rutin and Isoquercitrin: Tyrosinase Inhibition and Cytotoxicity.
Melanoma
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Melanoma
Fate of L-(3,5- 3H) tyrosine in cell-free extracts and tissue cultures of melanoma cells: a new assay method for tyrosinase in living cells.
Melanoma
Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function.
Melanoma
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Melanoma
Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway.
Melanoma
Ferritin light chain down-modulation generates depigmentation in human metastatic melanoma cells by influencing tyrosinase maturation.
Melanoma
Fibroblasts expressing mouse c locus tyrosinase produce an authentic enzyme and synthesize phaeomelanin.
Melanoma
Ficus deltoidea (Mas cotek) extract exerted anti-melanogenic activity by preventing tyrosinase activity in vitro and by suppressing tyrosinase gene expression in B16F1 melanoma cells.
Melanoma
Five-year results of prognostic value of tyrosinase in peripheral blood of uveal melanoma patients.
Melanoma
Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells.
Melanoma
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Melanoma
Flow cytometry assessment of residual melanoma cells in tumor-infiltrating lymphocyte cultures.
Melanoma
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Melanoma
Fluvastatin increases tyrosinase synthesis induced by alpha-melanocyte-stimulating hormone in B16F10 melanoma cells.
Melanoma
Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.
Melanoma
Formation of melanin-tyrosinase complex and its possible significance as a model for control of melanin synthesis.
Melanoma
Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells.
Melanoma
Frequency and relative fraction of tumor antigen-specific T cells among lymphocytes from melanoma-invaded lymph nodes.
Melanoma
Frequency of human leukocyte antigen-A 24 alleles in patients with melanoma determined by human leukocyte antigen-A sequence-based typing.
Melanoma
Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).
Melanoma
Functional analysis of tyrosinase isozymes of cultured malignant melanoma cells during the recovery period following interrupted melanogenesis induced by glycosylation inhibitors.
Melanoma
Functional T Cell Reactivity to Melanocyte Antigens Is Lost during the Progression of Malignant Melanoma, but Is Restored by Immunization.
Melanoma
Functionality study of santalin as tyrosinase inhibitor: A potential depigmentation agent.
Melanoma
Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis.
Melanoma
Functionalized Carbon Quantum Dots with Dopamine for Tyrosinase Activity Monitoring and Inhibitor Screening: In Vitro and Intracellular Investigation.
Melanoma
Galvanic zinc-copper microparticles inhibit melanogenesis via multiple pigmentary pathways.
Melanoma
gamma-Glutamyl transpeptidase, tyrosinase, and 5-S-cysteinyldopa production in melanoma cells.
Melanoma
Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.
Melanoma
Generalized melanosis secondary to malignant melanoma. Report of a case with serum and tissue tyrosinase studies.
Melanoma
Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptides in vivo: implications for tumor vaccines with melanoma-associated antigens.
Melanoma
Generation of polyclonal rabbit antisera to mouse melanoma associated antigens using gene gun immunization.
Melanoma
Genistein as an inducer of tumor cell differentiation: possible mechanisms of action.
Melanoma
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.
Melanoma
Giant congenital nodular melanoma in a newborn: a case report and literature review.
Melanoma
Glucocorticoid modulation of adrenocorticotropin-induced melanogenesis in the Cloudman S-91 melanoma in vitro.
Melanoma
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Melanoma
Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways.
Melanoma
Glycoproteins as differentiation markers in human malignant melanoma and melanocytes.
Melanoma
Glycosylation of tyrosinase is a determinant of melanin production in cultured melanoma cells.
Melanoma
gp100 mRNA is more sensitive than tyrosinase mRNA for RT-PCR amplification to detect circulating melanoma cells in peripheral blood of melanoma patients.
Melanoma
Granule-bound tyrosinase: solubilization and its relation to the soluble form of tyrosinase.
Melanoma
Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo.
Melanoma
Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression.
Melanoma
Hair dyes resorcinol and lawsone reduce production of melanin in melanoma cells by tyrosinase activity inhibition and decreasing tyrosinase and microphthalmia-associated transcription factor (MITF) expression.
Melanoma
Hairpin DNA coated gold nanoparticles as intracellular mRNA probes for the detection of tyrosinase gene expression in melanoma cells.
Melanoma
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.
Melanoma
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Melanoma
High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.
Melanoma
High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma.
Melanoma
High homogeneity of MAGE, BAGE, GAGE, tyrosinase and Melan-A/MART-1 gene expression in clusters of multiple simultaneous metastases of human melanoma: implications for protocol design of therapeutic antigen-specific vaccination strategies.
Melanoma
High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex.
Melanoma
Higher frequency of selective losses of HLA-A and -B allospecificities in metastasis than in primary melanoma lesions.
Melanoma
Highly Selective Fluorescent Probe Based on Hydroxylation of Phenylboronic Acid Pinacol Ester for Detection of Tyrosinase in Cells.
Melanoma
Highly selective suppression of melanoma cells by inducible DNA cross-linking agents: bis(catechol) derivatives.
Melanoma
Hinokitiol-induced decreases of tyrosinase and microphthalmia-associated transcription factor are mediated by the endoplasmic reticulum-associated degradation pathway in human melanoma cells.
Melanoma
Hispidin and related herbal compounds from Alpinia zerumbet inhibit both PAK1-dependent melanogenesis in melanocytes and reactive oxygen species (ROS) production in adipocytes.
Melanoma
Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9.
Melanoma
HLA-A(*)0201(+) Plasmacytoid Dendritic Cells Provide a Cell-Based Immunotherapy for Melanoma Patients.
Melanoma
HLA-independent heterogeneity of CD8+ T cell responses to MAGE-3, Melan-A/MART-1, gp100, tyrosinase, MC1R, and TRP-2 in vaccine-treated melanoma patients.
Melanoma
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
Melanoma
Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.
Melanoma
Human melanogenesis; the tyrosinase reaction in pigment cell neoplasms, with particular reference to the malignant melanoma; preliminary report.
Melanoma
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Melanoma
Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma.
Melanoma
Human placental protein/peptides stimulate melanin synthesis by enhancing tyrosinase gene expression.
Melanoma
Hybrid polymeric microspheres for enhancing the encapsulation of phenylethyl resorcinol.
Melanoma
Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules.
Melanoma
Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway.
Melanoma
Hydrogen peroxide increases a 55-kDa tyrosinase concomitantly with induction of p53-dependent p21 waf1 expression and a greater Bax/Bcl-2 ratio in pigmented melanoma.
Melanoma
Identification and characterization of mouse Rab32 by mRNA and protein expression analysis.
Melanoma
Identification and Characterization of the Tyrosinase Inhibitory Activity of Caffeine from Camellia Pollen.
Melanoma
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors.
Melanoma
Identification of a cis-acting element that enhances the pigment cell-specific expression of the human tyrosinase gene.
Melanoma
Identification of a new shared HLA-A2.1 restricted epitope from the melanoma antigen tyrosinase.
Melanoma
Identification of a New Shared HLA-A2.1 Restricted Epitope From the Melanoma Antigen Tyrosinase.
Melanoma
Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.
Melanoma
Identification of five new HLA-B*3501-restricted epitopes derived from common melanoma-associated antigens, spontaneously recognized by tumor-infiltrating lymphocytes.
Melanoma
Identification of HLA-A*03, A*11 and B*07-restricted melanoma-associated peptides that are immunogenic in vivo by vaccine-induced immune response (VIIR) analysis.
Melanoma
Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment.
Melanoma
Identification of L-Cysteinamide as a Potent Inhibitor of Tyrosinase-Mediated Dopachrome Formation and Eumelanin Synthesis.
Melanoma
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression.
Melanoma
Identification of Mushroom and Murine Tyrosinase Inhibitors from Achillea biebersteinii Afan. Extract.
Melanoma
Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles.
Melanoma
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.
Melanoma
Identification of the immunodominant regions of the melanoma antigen tyrosinase by anti-tyrosinase monoclonal antibodies.
Melanoma
Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon.
Melanoma
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
Melanoma
Immune responses to the HLA-A*0201-restricted epitopes of tyrosinase and glycoprotein 100 enable control of melanoma outgrowth in HLA-A*0201-transgenic mice.
Melanoma
Immune-related Adverse Events of Dendritic Cell Vaccination Correlate With Immunologic and Clinical Outcome in Stage III and IV Melanoma Patients.
Melanoma
Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo.
Melanoma
Immunobead-based detection and characterization of circulating tumor cells in melanoma patients.
Melanoma
Immunochemical detection of tyrosinase in serum of patients with metastatic malignant melanomas. and from Hardy-Passey mouse melanomas.
Melanoma
Immunoelectron microscopic demonstration of human melanosome associated antigens (HMSA) on melanoma cells: comparison with tyrosinase distribution.
Melanoma
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients.
Melanoma
Immunohistochemical Identification of Canine Melanocytic Neoplasms With Antibodies to Melanocytic Antigen PNL2 and Tyrosinase: Comparison With Melan A.
Melanoma
Immunohistochemical Study of Melanocyte-Melanocyte Stem Cell lineage in Vitiligo; A Clue to Interfollicular Melanocyte Stem Cell Reservoir.
Melanoma
Immunohistochemistry and sentinel node biopsy in melanoma: the use of tyrosinase and Melan-A.
Melanoma
Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma.
Melanoma
Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells.
Melanoma
Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas.
Melanoma
Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.
Melanoma
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
Melanoma
Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma.
Melanoma
Immunosuppressive cytokines in the regional lymph node of a dog suffering from oral malignant melanoma.
Melanoma
Impact of molecular staging methods in primary melanoma: reverse-transcriptase polymerase chain reaction (RT-PCR) of ultrasound-guided aspirate of the sentinel node does not improve diagnostic accuracy, but RT-PCR of peripheral blood does predict survival.
Melanoma
Impairment of the melanogenic pathway in B16 melanoma cells transfected with class I H-2 genes.
Melanoma
Improved antimelanogenesis and antioxidant effects of polysaccharide from Cuscuta chinensis Lam seeds after enzymatic hydrolysis.
Melanoma
Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase.
Melanoma
In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients.
Melanoma
In vitro and cellular activities of the selected fruits residues for skin aging treatment.
Melanoma
In vitro effects of hormonal stimuli upon tyrosinase and peroxidase activities in murine melanomas.
Melanoma
In vitro effects of melanocytolytic agents and other compounds upon dominant human melanoma tyrosinase activity.
Melanoma
In vitro growth inhibition of S-91 mouse melanomas by tyrosinase substrate analogs with and without L-cysteine.
Melanoma
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Melanoma
In vivo inhibition of the tyrosinase of hamster melanoma with sodium diethyldithiocarbamate.
Melanoma
Incomplete expression of the tyrosinase gene family (tyrosinase, TRP-1, and TRP-2) in human malignant melanoma cells in vitro.
Melanoma
Incorporation of [125I]-5-iodo-2-thiouracil in cultured hamster, rabbit, and human melanoma cells.
Melanoma
Increased detection of metastatic melanoma in pediatric sentinel lymph node biopsies using RT-PCR on paraffin-embedded tissue.
Melanoma
Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
Melanoma
Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction.
Melanoma
Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series.
Melanoma
Individualized synthetic peptide vaccines with GM-CSF in locally advanced melanoma patients.
Melanoma
Induction of melanogenesis during the various melanoma growth phases and the role of tyrosinase, lysosome-associated membrane proteins, and p90 calnexin in the melanogenesis cascade.
Melanoma
Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.
Melanoma
Induction of pigmentation by a small molecule tyrosine kinase inhibitor nilotinib.
Melanoma
Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.
Melanoma
Induction of tyrosinase in human melanoma cells by L-tyrosine phosphate and cytochalasin D.
Melanoma
Induction of tyrosinase-reactive T cells by treatment with dacarbazine, cisplatin, interferon-alpha +/- interleukin-2 in patients with metastatic melanoma.
Melanoma
Influence of N-glycan processing disruption on tyrosinase and melanin synthesis in HM3KO melanoma cells.
Melanoma
Inhibition effect of phenyl compounds from the Oryza sativa roots on melanin production in murine B16-F10 melanoma cells.
Melanoma
Inhibition of imidazole-induced tyrosinase activity by estradiol and estriol in cultured B16/C3 melanoma cells.
Melanoma
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Melanoma
Inhibition of L-tyrosine-induced micronuclei production by phenylthiourea in human melanoma cells.
Melanoma
Inhibition of Mek 1/2 kinase activity and stimulation of melanogenesis by 5,7-dimethoxycoumarin treatment of melanoma cells.
Melanoma
Inhibition of Melanogenesis in Murine B16/F10 Melanoma Cells by Ligusticum sinensis Oliv.
Melanoma
Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor.
Melanoma
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.
Melanoma
Inhibition of tyrosinase activity and melanin production by the chalcone derivative 1-(2-cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone.
Melanoma
Inhibition of tyrosinase activity and protein synthesis in melanoma cells by calcium ionophore A23187.
Melanoma
Inhibition of tyrosinase activity by 4-tert-butylcatechol and other depigmenting agents.
Melanoma
Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells.
Melanoma
Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies.
Melanoma
Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression.
Melanoma
Inhibitory effect of brazilein on tyrosinase and melanin synthesis: Kinetics and in silico approach.
Melanoma
Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.
Melanoma
Inhibitory Effect of Elaeagnus umbellata Fractions on Melanogenesis in ?-MSH-Stimulated B16-F10 Melanoma Cells.
Melanoma
Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma.
Melanoma
Inhibitory effect of Gastrodia elata extract on melanogenesis in HM3KO melanoma cells.
Melanoma
Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.
Melanoma
Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo.
Melanoma
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Melanoma
Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells.
Melanoma
Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells.
Melanoma
Inhibitory Effect of Rose Hip (Rosa canina L.) on Melanogenesis in Mouse Melanoma Cells and on Pigmentation in Brown Guinea Pigs.
Melanoma
Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses.
Melanoma
Inhibitory effect of sodium 5,6-benzylidene ascorbate (SBA) on the elevation of melanin biosynthesis induced by ultraviolet-A (UV-A) light in cultured B-16 melanoma cells.
Melanoma
Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action.
Melanoma
Inhibitory effects of 1-O-methyl-fructofuranose from Schisandra chinensis fruit on melanogenesis in B16F0 melanoma cells.
Melanoma
Inhibitory effects of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on melanogenesis.
Melanoma
Inhibitory effects of autolysate of Leuconostoc mesenteroides isolated from kimoto on melanogenesis.
Melanoma
Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis.
Melanoma
Inhibitory effects of plant extracts on tyrosinase, L-DOPA oxidation, and melanin synthesis.
Melanoma
Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin.
Melanoma
Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin.
Melanoma
Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells.
Melanoma
Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.
Melanoma
Insect cells as HLA-restricted antigen-presenting cells for the IFN-gamma elispot assay.
Melanoma
Insight into Mechanistic Action of Thymoquinone Induced Melanogenesis in Cultured Melanocytes.
Melanoma
Insulin inhibits tyrosinase activity and 5-S-cysteinyldopa formation in human melanoma cells.
Melanoma
Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
Melanoma
Insulin-mediated inhibition of tyrosinase activity and protein synthesis in melanoma cell cultures.
Melanoma
Interaction of ACTH, corticosterone and cyclic nucleotides in Harding-Passey melanoma melanogenesis.
Melanoma
Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells.
Melanoma
Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells.
Melanoma
Interlaboratory evaluation of a new reverse transcriptase polymerase chain reaction-based enzyme-linked immunosorbent assay for the detection of circulating melanoma cells: a multicenter study of the Dermatologic Cooperative Oncology Group.
Melanoma
Interleukin-2: developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity.
Melanoma
Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens.
Melanoma
Internal binding sites for MSH: analyses in wild-type and variant Cloudman melanoma cells.
Melanoma
Intra-Lymph Node Prime-Boost Vaccination Against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial.
Melanoma
Intracellular localization of tyrosinase inhibitor in amelanotic and melanotic malignant melanoma.
Melanoma
Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients.
Melanoma
Intratumoral T-cell infiltrates and MHC class I expression in patients with stage IV melanoma.
Melanoma
Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient.
Melanoma
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo.
Melanoma
Investigation of the Anti-Melanogenic and Antioxidant Characteristics of Eucalyptus camaldulensis Flower Essential Oil and Determination of Its Chemical Composition.
Melanoma
Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells.
Melanoma
Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.
Melanoma
Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein.
Melanoma
Involvement of the p38 MAPK and ERK signaling pathway in the anti-melanogenic effect of methyl 3,5-dicaffeoyl quinate in B16F10 mouse melanoma cells.
Melanoma
Iodination of beta-melanotropin. Time course analysis of reaction mixtures by high pressure liquid chromatography and characterization of biologically active mono- and diiodo-beta-melanotropin.
Melanoma
Isolated organ perfusion does not result in systemic microembolization of tumor cells.
Melanoma
Isolation and biochemical characterization of tyrosinase-rich GERL and coated vesicle in melanin synthesizing cells.
Melanoma
Isolation and characterization of a Golgi-rich fraction from the Harding-Passey mouse melanoma.
Melanoma
Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcellular compartments in amelanotic and melanomas.
Melanoma
Isolation of a unique melanogenic inhibitor from human skin xenografts: initial in vitro and in vivo characterization.
Melanoma
Isolation of tyrosinase and melanogenesis inhibitory flavonoids from Juniperus chinensis fruits.
Melanoma
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.
Melanoma
KBA62 and PNL2: 2 new melanoma markers-immunohistochemical analysis of 1563 tumors including metastatic, desmoplastic, and mucosal melanomas and their mimics.
Melanoma
Kinetic and sensitive analysis of tyrosinase activity using electron transfer complexes: in vitro and intracellular study.
Melanoma
L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells.
Melanoma
L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells.
Melanoma
Lack of prognostic importance of reverse-transcriptase polymerase chain reaction detection of circulating messenger RNA in patients with melanoma.
Melanoma
Lacrimal Sac Malignant Melanoma in 15 Japanese Patients: Case Report and Literature Review.
Melanoma
Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication.
Melanoma
Lentivirus vector-mediated expression of tumor-associated epitopes by human antigen presenting cells.
Melanoma
Limitations of the nested reverse transcriptase polymerase chain reaction on tyrosinase for the detection of malignant melanoma micrometastases in lymph nodes.
Melanoma
Linear and cyclic alpha-melanotropin [4-10]-fragment analogues that exhibit superpotency and residual activity.
Melanoma
Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Melanogenesis in B16F10 Mouse Melanoma Cells.
Melanoma
Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells.
Melanoma
Long-term and residual melanotropin-stimulated tyrosinase activity in S91 melanoma cells is density dependent.
Melanoma
Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides.
Melanoma
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
Melanoma
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.
Melanoma
Loss of melanogenic properties in tyrosinases induced by glucosylation inhibitors within malignant melanoma cells.
Melanoma
Lyoniresinol inhibits melanogenic activity through the induction of microphthalmia-associated transcription factor and extracellular receptor kinase activation.
Melanoma
Magnetic bead RT-PCR: establishment of a new method for detecting circulating melanoma cells.
Melanoma
Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid.
Melanoma
Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases.
Melanoma
Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.
Melanoma
Mangosteen leaf extract increases melanogenesis in B16F1 melanoma cells by stimulating tyrosinase activity in vitro and by up-regulating tyrosinase gene expression.
Melanoma
Mannosylerythritol lipid is a potent inducer of apoptosis and differentiation of mouse melanoma cells in culture.
Melanoma
MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases.
Melanoma
MART-1/Melan-A and tyrosinase transcripts in peripheral blood of melanoma patients: PCR analyses and follow-up testing in relation to clinical stage and disease progression.
Melanoma
MCW melanoma cocktail for the evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma.
Melanoma
Mechanism and inhibitory effect of galangin and its flavonoid mixture from Alpinia officinarum on mushroom tyrosinase and B16 murine melanoma cells.
Melanoma
Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models.
Melanoma
Mechanism(s) regulating inhibition of thymidylate synthase and growth by gamma-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells.
Melanoma
Melanin accelerates the tyrosinase-catalyzed oxygenation of p-hydroxyanisole (MMEH)
Melanoma
Melanin formation in the inner ear is catalyzed by a new tyrosine hydroxylase kinetically and structurally different from tyrosinase.
Melanoma
Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo.
Melanoma
Melanocyte culture lines from Tyr-SV40E transgenic mice: models for the molecular genetic evolution of malignant melanoma.
Melanoma
Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.
Melanoma
Melanocyte differentiation marker gp75, the brown locus protein, can be regulated independently of tyrosinase and pigmentation.
Melanoma
Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes.
Melanoma
Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma.
Melanoma
Melanocyte-stimulating hormone (alpha-MSH) inhibits the growth of human malignant melanoma cells with the induction of phosphatidyl inositol and myo-inositol phosphate levels.
Melanoma
Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells.
Melanoma
Melanocytotoxicity and antimelanoma effects of phenolic amine compounds in mice in vivo.
Melanoma
Melanogenesis effect of Cordyceps militaris culture broth on the melanin formation of B16F0 melanoma cells.
Melanoma
Melanogenesis in genetically determined pigment cell tumors of platyfish and platyfish-swordtail hybrids: correlation between tyrosine activity and degree of malignancy.
Melanoma
Melanogenesis inhibitory activities of diarylheptanoids from Alnus hirsuta Turcz in B16 mouse melanoma cell.
Melanoma
Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.
Melanoma
Melanogenic response of the Kupffer cells of Rana esculenta L to melanocyte stimulating hormone.
Melanoma
Melanoma cells present high levels of HLA-A2-tyrosinase in association with instability and aberrant intracellular processing of tyrosinase.
Melanoma
Melanoma genomics reveals signatures of sensitivity to bio- and targeted therapies.
Melanoma
Melanoma x macrophage fusion hybrids acquire increased melanogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism.
Melanoma
Melanoma-associated antigen tyrosinase but not Melan-A/MART-1 expression and presentation dissociate during the heat shock response.
Melanoma
Melanoma-inhibiting activity (MIA) mRNA is not exclusively transcribed in melanoma cells: low levels of MIA mRNA are present in various cell types and in peripheral blood.
Melanoma
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Melanoma
Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancers.
Melanoma
Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles.
Melanoma
Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens.
Melanoma
Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells.
Melanoma
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
Melanoma
Melatonin antagonizes alpha-melanocyte-stimulating hormone enhancement of melanogenesis in mouse melanoma cells by blocking the hormone-induced accumulation of the c locus tyrosinase.
Melanoma
Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species.
Melanoma
Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells.
Melanoma
Metastatic potential of human melanoma cells in nude mice--characterisation of phenotype, cytokine secretion and tumour-associated antigens.
Melanoma
Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics.
Melanoma
MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-?B signaling pathway through the downregulation of oxidative stress.
Melanoma
MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma.
Melanoma
Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease.
Melanoma
Microheterogeneity of melanosome-bound tyrosinase from the Harding-Passey murine melanoma.
Melanoma
Microphthalmia-associated transcription factor and tyrosinase as markers of melanoma cells in blood of patients with melanoma.
Melanoma
Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene.
Melanoma
Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells.
Melanoma
Micropthalmia transcription factor (MITF) as a diagnostic marker for metastatic melanomas negative for other melanoma markers.
Melanoma
MicroRNA-203 Regulates Melanosome Transport and Tyrosinase Expression in Melanoma Cells by Targeting Kinesin Superfamily Protein 5b.
Melanoma
microRNA-374 inhibits proliferation and promotes apoptosis of mouse melanoma cells by inactivating the Wnt signalling pathway through its effect on tyrosinase.
Melanoma
Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase.
Melanoma
Minimally invasive staging of patients with melanoma: sentinel lymphadenectomy and detection of the melanoma-specific proteins MART-1 and tyrosinase by reverse transcriptase polymerase chain reaction.
Melanoma
MiR-330-5p regulates tyrosinase and PDIA3 expression and suppresses cell proliferation and invasion in cutaneous malignant melanoma.
Melanoma
MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma.
Melanoma
Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma-associated antigen: induction of tyrosinase- and melanoma-specific human leukocyte antigen A*0201-restricted cytotoxic T cells in vitro and in vivo.
Melanoma
Modifying effects of carboxyl group on the interaction of recombinant S100A8/A9 complex with tyrosinase.
Melanoma
Modulation of 5-S-cysteinyldopa formation by tyrosinase activity and intracellular thiols in human melanoma cells.
Melanoma
Modulation of antioxidant defense by Alpinia galanga and Curcuma aromatica extracts correlates with their inhibition of UVA-induced melanogenesis.
Melanoma
Modulation of antioxidant enzymes p21WAF1 and p53 expression during proliferation and differentiation of human melanoma cell lines.
Melanoma
Modulation of tyrosinase activity and viral information by 5-iodo-deoxyuridine and L-dopa in a human melanoma cell line [proceedings]
Melanoma
Molecular and biochemical testing in stage III melanoma: multimarker reverse transcriptase-polymerase chain reaction assay of lymph fluid after lymph node dissection and preoperative serum lactate dehydrogenase level.
Melanoma
Molecular and prognostic classification of advanced melanoma: a multi-marker microcontamination assay of peripheral blood stem cells.
Melanoma
Molecular bases of tyrosinase-negative oculocutaneous albinism: a single base insertion or a missense point mutation in the tyrosinase gene.
Melanoma
Molecular control of melanogenesis in malignant melanoma: functional assessment of tyrosinase and lamp gene families by UV exposure and gene co-transfection, and cloning of a cDNA encoding calnexin, a possible melanogenesis "chaperone".
Melanoma
Molecular detection of circulating tyrosinase mRNA: optimization in a preclinical xenograft mouse melanoma model and further evaluation in samples from advanced melanoma patients.
Melanoma
Molecular detection of MART-1, tyrosinase and MIA in peripheral blood, lymph nodes and metastatic sites of stage III/IV melanoma patients.
Melanoma
Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.
Melanoma
Molecular detection of tyrosinase transcripts in peripheral blood from patients with malignant melanoma: correlation of PCR sensitivity threshold with clinical and pathologic disease characteristics.
Melanoma
Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity.
Melanoma
Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma.
Melanoma
Molecular mechanisms governing melanogenesis in hamster melanomas: relative abundance of tyrosinase and catalase-B (gp 75).
Melanoma
Molecular staging by multimarker reverse transcriptase-polymerase chain reaction assay of lymphatic drainage and blood from melanoma patients after lymph node dissection.
Melanoma
Molecular staging in stage II and III melanoma patients and its effect on long-term survival.
Melanoma
Molecular staging of the sentinel lymph node in melanoma patients: correlation with clinical outcome.
Melanoma
Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients.
Melanoma
Molecular tumor markers in the blood: early prediction of disease outcome in melanoma patients treated with a melanoma vaccine.
Melanoma
Monitoring Tyrosinase Expression in Non-metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy.
Melanoma
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells.
Melanoma
Monoclonal antibody against a melanosomal protein in melanotic and amelanotic human melanoma cells.
Melanoma
Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells.
Melanoma
Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.
Melanoma
Morin Induces Melanogenesis via Activation of MAPK Signaling Pathways in B16F10 Mouse Melanoma Cells.
Melanoma
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.
Melanoma
MSH stimulates adenylate cyclase and tyrosinase in cultivated melanoma cells in the presence of cytochalasin B.
Melanoma
Multi-hormonal regulation of tyrosinase expression in B16/C3 melanoma cells in culture.
Melanoma
Multimarker real-time reverse transcription-PCR for quantitative detection of melanoma-associated antigens: a novel possible staging method.
Melanoma
Multiple RT-PCR tyrosinase testing reveals that melanoma cells circulate in the blood of melanoma patients at the frequency more than 10 times below the detection threshold.
Melanoma
Murine tyrosinase expressed by a T7 vector in bone marrow-derived dendritic progenitors effectively prevents and eradicates melanoma tumors in mice.
Melanoma
Murine tyrosinase Inhibitors from Cynanchum bungei and evaluation of in vitro and in vivo depigmenting activity.
Melanoma
N-(3,5-Dihydroxybenzoyl)-6-hydroxytryptamine as a Novel Human Tyrosinase Inhibitor That Inactivates the Enzyme in Cooperation with L-3,4-Dihydroxyphenylalanine.
Melanoma
N-linked carbohydrates in tyrosinase are required for its recognition by human MHC class II-restricted CD4(+) T cells.
Melanoma
N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer.
Melanoma
N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation.
Melanoma
N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.
Melanoma
Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase: Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment.
Melanoma
Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish.
Melanoma
Nanoliposomes encapsulation of enriched phenolic fraction from pistachio hulls and its antioxidant, anti-inflammatory, and anti-melanogenic activities.
Melanoma
Natural T cell autoreactivity to melanoma antigens: clonally expanded melanoma-antigen specific CD8?+?memory T cells can be detected in healthy humans.
Melanoma
Nature and biosynthesis of structural matrix protein in melanosomes: melanosomal structural protein as differentiation antigen for neoplastic melanocytes.
Melanoma
New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations.
Melanoma
New Methodological Approach for the Rapid and Sensitive Detection of Melanocytes and Melanocytic Tumours. The DOPA-GA Method.
Melanoma
New nitrosoureas and their spin-labeled derivatives influence dopa-oxidase activity of tyrosinase.
Melanoma
Nicotinic acid hydroxamate downregulated the melanin synthesis and tyrosinase activity through activating the MEK/ERK and AKT/GSK3? signaling pathways.
Melanoma
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Melanoma
No correlation of tyrosinase mRNA in bone marrow with prognosis of metastatic melanoma.
Melanoma
Non-premelanosomal and premelanosomal tyrosinase activity in Greene's amelanotic and melanotic malignant melanoma.
Melanoma
Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis.
Melanoma
Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies.
Melanoma
Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients.
Melanoma
Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells.
Melanoma
Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy.
Melanoma
Novel genes associated with malignant melanoma but not benign melanocytic lesions.
Melanoma
Novel oncolytic adenoviruses targeted to melanoma: specific viral replication and cytolysis by expression of E1A mutants from the tyrosinase enhancer/promoter.
Melanoma
Novel Quercetin Derivative of 3,7-Dioleylquercetin Shows Less Toxicity and Highly Potent Tyrosinase Inhibition Activity.
Melanoma
Novel tyramide-based tyrosinase assay for the detection of melanoma cells in cytological preparations.
Melanoma
NY-ESO-1 and CTp11 expression may correlate with stage of progression in melanoma.
Melanoma
Octaphlorethol A isolated from Ishige foliacea inhibits ?-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells.
Melanoma
Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens.
Melanoma
Oenothera laciniata Hill Extracts Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16-F10 Cells via Downregulating CREB/MITF/Tyrosinase and Upregulating p-ERK and p-JNK.
Melanoma
Oligoesculin fraction induces anti-tumor effects and promotes immune responses on B16-F10 mice melanoma.
Melanoma
Opposite regulation of tyrosinase and glutathione peroxidase by intracellular thiols in human melanoma cells.
Melanoma
Optimal detection of sentinel lymph node metastases by intraoperative radioactive threshold and molecular analysis in patients with melanoma.
Melanoma
Optimization of Phenolics Extracted from Idesia polycarpa Defatted Fruit Residue and Its Antioxidant and Depigmenting Activity In Vitro and In Vivo.
Melanoma
Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.
Melanoma
Optimization of Ultrasonic Flavonoid Extraction from Saussurea involucrate, and the Ability of Flavonoids to Block Melanin Deposition in Human Melanocytes.
Melanoma
Over-production of a glycoside hydrolase family 50 beta-agarase from Agarivorans sp. JA-1 in Bacillus subtilis and the whitening effect of its product.
Melanoma
Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action.
Melanoma
Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo.
Melanoma
p-Alkoxyphenols, a new class of inhibitors of mammalian R2 ribonucleotide reductase: possible candidates for antimelanotic drugs.
Melanoma
p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects.
Melanoma
p-Coumaric acid, a constituent of Sasa quelpaertensis Nakai, inhibits cellular melanogenesis stimulated by alpha-melanocyte stimulating hormone.
Melanoma
Partial tyrosinase-specific self tolerance by HLA-A*0201-restricted cytotoxic T lymphocytes in mice and man.
Melanoma
Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells.
Melanoma
Particulate tyrosinase of human malignant melanoma. Solubilization, purification following trypsin treatment, and characterization.
Melanoma
Pathologic assessment of melanoma sentinel nodes: a role for molecular analysis using quantitative real-time reverse transcription-PCR for MART-1 and tyrosinase messenger RNA.
Melanoma
Pathology and ultrastructural characteristics of a hypomelanotic variant of transplantable hamster melanoma with elevated tyrosinase activity.
Melanoma
Paucity of functional T-cell memory to melanoma antigens in healthy donors and melanoma patients.
Melanoma
Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.
Melanoma
Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma.
Melanoma
pH-dependent interconvertible allosteric forms of murine melanoma tyrosinase. Physiological implications.
Melanoma
pH-dependent interconvertible forms of mushroom tyrosinase with different kinetic properties.
Melanoma
pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells.
Melanoma
Phase 2 trial of vaccination with tyrosinase peptides and granulocyte-macrophage colony-stimulating factor in patients with metastatic melanoma.
Melanoma
Phase I evaluation of interleukin-2-transfected irradiated allogeneic melanoma for the treatment of metastatic melanoma: appendix 1: protocol.
Melanoma
Phase I study of intranodal delivery of a plasmid DNA vaccine for patients with Stage IV melanoma.
Melanoma
Phase I/II study of treatment with dendritic cell vaccines in patients with disseminated melanoma.
Melanoma
Phase I/II study of treatment with matured dendritic cells with or without low dose IL-2 in patients with disseminated melanoma.
Melanoma
Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma.
Melanoma
Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment.
Melanoma
Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells.
Melanoma
Phlorotannins with Potential Anti-tyrosinase and Antioxidant Activity Isolated from the Marine Seaweed Ecklonia stolonifera.
Melanoma
PHrmonal specificity of the melanotropin-sensitive adenylate cyclase of mouse melanoma and effect of cyclic AMP on the tyrosinase activity of mouse melanoma cells, in vitro.
Melanoma
Phytochemical capacity of Nitraria retusa leaves extracts inhibiting growth of melanoma cells and enhancing melanogenesis of B16F10 melanoma.
Melanoma
Phytochemical potential of Daphne gnidium in inhibiting growth of melanoma cells and enhancing melanogenesis of B16-F0 melanoma.
Melanoma
Pigment content of cultured human melanocytes does not correlate with tyrosinase message level.
Melanoma
Pigment production in murine melanoma cells is regulated by tyrosinase, tyrosinase-related protein 1 (TRP1), DOPAchrome tautomerase (TRP2), and a melanogenic inhibitor.
Melanoma
Pigment-cell-specific genes from fibroblasts are transactivated after chromosomal transfer into melanoma cells.
Melanoma
Pigmentation Levels Affect Melanoma Responses to Coriolus versicolor Extract and Play a Crucial Role in Melanoma-Mononuclear Cell Crosstalk.
Melanoma
Pigmentation-associated glycoprotein of human melanomas and melanocytes: definition with a mouse monoclonal antibody.
Melanoma
Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.
Melanoma
Pilot study of safety and feasibility of DNA microseeding for treatment of spontaneous canine melanoma.
Melanoma
Plumbagin Suppresses ?-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity.
Melanoma
Polymerase chain reaction detection of melanoma cells in the circulation: relation to clinical stage, surgical treatment, and recurrence from melanoma.
Melanoma
Polymerase chain reaction in the detection of circulating tumour cells in peripheral blood of melanoma patients.
Melanoma
Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein.
Melanoma
Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis.
Melanoma
Possible relationship between abnormal melanosome structure and cytotoxic phenomena in malignant melanoma.
Melanoma
Potent and prolonged melanotropic activities of the alpha-MSH fragment analog, Ac-[Nle4,D-Phe7]-alpha-MSH4-9-NH2.
Melanoma
Potent melanin production enhancement of human tyrosinase gene by Tat and an entrapment in elastic cationic niosomes: Potential application in vitiligo gene therapy.
Melanoma
PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91.
Melanoma
Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy.
Melanoma
Prediction of disease outcome in melanoma patients by molecular analysis of paraffin-embedded sentinel lymph nodes.
Melanoma
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Melanoma
Preparation of purified tyrosinase devoid of dopachrome tautomerase from mammalian malignant melanocytes.
Melanoma
Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.
Melanoma
Prevention of an additional surgery for regional lymphadenectomy in melanoma: Rapid intraoperative immunostaining of sentinel lymph node imprint smears.
Melanoma
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.
Melanoma
Proanthocyanidins isolated from the leaves of Photinia × fraseri block the cell cycle and induce apoptosis by inhibiting tyrosinase activity in melanoma cells.
Melanoma
Proanthocyanidins purified from fruit pericarp of Clausena lansium (Lour.) Skeels as efficient tyrosinase inhibitors: structure evaluation, inhibitory activity and molecular mechanism.
Melanoma
Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time.
Melanoma
Prognostic relevance of baseline and sequential peripheral blood tyrosinase expression in 200 consecutive advanced metastatic melanoma patients.
Melanoma
Prognostic role of circulating melanoma cells detected by reverse transcriptase-polymerase chain reaction for tyrosinase mRNA in patients with melanoma.
Melanoma
Prognostic significance and diagnostic value of protein S-100 and tyrosinase in patients with malignant melanoma.
Melanoma
Prognostic significance of detecting micrometastases by tyrosinase RT/PCR in sentinel lymph node biopsies: lessons from 322 consecutive melanoma patients.
Melanoma
Prognostic Significance of Molecular Staging Study of Sentinel Lymph Nodes by Reverse Transcriptase-Polymerase Chain Reaction for Tyrosinase in Melanoma Patients.
Melanoma
Prognostic significance of molecular staging study of sentinel lymph nodes by reverse transcriptase-polymerase chain reaction for tyrosinase in melanoma patients.
Melanoma
Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients.
Melanoma
Prognostic significance of peripheral blood and bone marrow tyrosinase messenger RNA in malignant melanoma.
Melanoma
Prognostic significance of the detection of circulating malignant cells by reverse transcriptase-polymerase chain reaction in long-term clinically disease-free melanoma patients.
Melanoma
Prognostic significance of the sequential detection of circulating melanoma cells by RT-PCR in high-risk melanoma patients receiving adjuvant interferon.
Melanoma
Prognostic significance of tyrosinase expression in sentinel lymph node biopsy for ultra-thin, thin, and thick melanomas.
Melanoma
Prognostic significance of tyrosinase mRNA detected by nested RT-PCR in patients with malignant melanoma.
Melanoma
Prognostic value of microphthalmia-associated transcription factor and tyrosinase as markers for circulating tumor cells detection in patients with melanoma.
Melanoma
Prognostic value of multiple reverse transcription-PCR tyrosinase testing for circulating neoplastic cells in malignant melanoma.
Melanoma
Prognostic value of RT-PCR tyrosinase detection in peripheral blood of melanoma patients.
Melanoma
Prognostic value of tyrosinase reverse transcriptase PCR analysis in melanoma sentinel lymph nodes: long-term follow-up analysis.
Melanoma
Prognostic value of tyrosinase reverse-transcriptase polymerase chain reaction in metastatic melanoma.
Melanoma
Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted alpha-melanotropins.
Melanoma
Proper folding and endoplasmic reticulum to golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine.
Melanoma
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.
Melanoma
Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain.
Melanoma
Protein kinase Calpha plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells.
Melanoma
Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells.
Melanoma
Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity.
Melanoma
Psoralens stimulate mouse melanocyte and melanoma tyrosinase activity in the absence of ultraviolet light.
Melanoma
Purification of hamster melanoma tyrosinases and structural studies of their asparagine-linked sugar chains.
Melanoma
Purification of tyrosinase to homogeneity based on its resistance to sodium dodecyl sulfate-proteinase K digestion.
Melanoma
Pyrroloquinoline quinone (PQQ) inhibits the expression of tyrosinase mRNA by alpha-melanocyte stimulating hormone in murine B16 melanoma cells.
Melanoma
Qualitative and quantitative catalog of tyrosinase alternative transcripts in normal murine skin melanocytes as a basis for detecting melanoma-specific changes.
Melanoma
Quantification of melanoma micrometastases in sentinel lymph nodes using real-time RT-PCR.
Melanoma
Quantitative analysis of tyrosinase and tyrosinase-related protein-2 mRNA from melanoma cells in blood by real-time polymerase chain reaction.
Melanoma
Quantitative detection of melanoma-associated antigens by multimarker real-time RT-PCR for molecular staging: results of a 5 years study.
Melanoma
Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease.
Melanoma
Quantitative real-time RT-PCR as a method for monitoring T lymphocyte reactivity to full-length tyrosinase protein in vaccinated melanoma patients.
Melanoma
Quantitative real-time RT-PCR in sentinel lymph nodes from melanoma patients. Detection of melanocytic mRNA predicts disease-free survival.
Melanoma
Quantitative RT-PCR assessment of melanoma cells in peripheral blood during immunotherapy for metastatic melanoma.
Melanoma
Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy.
Melanoma
Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes.
Melanoma
Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase.
Melanoma
Quercetin-3-O-?-d-glucopyranosyl-(1 ? 6)-?-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.
Melanoma
Rapid and reversible inhibition of tyrosinase activity by glucosidase inhibitors in human melanoma cells.
Melanoma
Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma.
Melanoma
Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity.
Melanoma
Reactivity of orthoquinones involved in tyrosinase-dependent cytotoxicity: differences between alkylthio- and alkoxy-substituents.
Melanoma
Reactivity to tyrosinase: expression in cancer (melanoma) and autoimmunity (vitiligo).
Melanoma
Receptor binding affinities and biological activities of linear and cyclic melanocortins in B16 murine melanoma cells expressing the native MC1 receptor.
Melanoma
Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.
Melanoma
Reduction of DNA synthesis, pigment synthesis, pigmentation gene mRNA and resistance to UVB in human melanoma cells treated with analogues of a histamine (H2) agonist.
Melanoma
Regulated folding of tyrosinase in the endoplasmic reticulum demonstrates that misfolded full-length proteins are efficient substrates for class I processing and presentation.
Melanoma
Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
Melanoma
Regulation of mammalian melanogenesis. I: Partial purification and characterization of a dopachrome converting factor: dopachrome tautomerase.
Melanoma
Regulation of melanogenesis induced by 5-methoxypsoralen without ultraviolet light in murine melanoma cells.
Melanoma
Regulation of melanogenesis through phosphatidylinositol 3-kinase-Akt pathway in human G361 melanoma cells.
Melanoma
Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.
Melanoma
Regulation of the cytosolic and melanosome-bound tyrosinase activities in Harding-Passey mouse melanoma.
Melanoma
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Melanoma
Regulation of tyrosinase expression and activity in human melanoma cells via histamine receptors.
Melanoma
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Melanoma
Regulation of tyrosinase mRNA in mouse melanoma cells by alpha-melanocyte-stimulating hormone.
Melanoma
Regulation of tyrosinase mRNA levels in mouse melanoma cell clones by melanocyte-stimulating hormone and cyclic AMP.
Melanoma
Reliability of reverse transcription-polymerase chain reaction (RT-PCR)-based assays for the detection of circulating tumour cells: a quality-assurance initiative of the EORTC Melanoma Cooperative Group.
Melanoma
Repeated UVB irradiations do not have the same potential to promote stimulation of melanogenesis in cultured normal human melanocytes.
Melanoma
Reproducibility of detection of tyrosinase and MART-1 transcripts in the peripheral blood of melanoma patients: a quality control study using real-time quantitative RT-PCR.
Melanoma
Responsive Mn(II) complexes for potential applications in diagnostic Magnetic Resonance Imaging.
Melanoma
Results of the determination of serum markers in patients with malignant melanoma.
Melanoma
Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine.
Melanoma
Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines.
Melanoma
Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo.
Melanoma
Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line.
Melanoma
Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of nonsentinel nodes following completion lymphadenectomy for melanoma.
Melanoma
Reverse transcriptase-polymerase chain reaction detection of circulating tumor cells in patients with melanoma: correlation with clinical stage, tumor thickness and histological type.
Melanoma
Reverse transcriptase-polymerase chain reaction for expression of tyrosinase to identify malignant melanoma cells in peripheral blood.
Melanoma
Rhapontigenin converted from rhapontin purified from Rheum undulatum enhances the inhibition of melanin synthesis.
Melanoma
Role of gene expression and protein synthesis of tyrosinase, TRP-1, lamp-1, and CD63 in UVB-induced melanogenesis in human melanomas.
Melanoma
Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.
Melanoma
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
Melanoma
Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression.
Melanoma
Rose Petal Extract (Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects.
Melanoma
Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients.
Melanoma
RT-PCR detection of tyrosinase, gp100, MART1/Melan-A, and TRP-2 gene transcripts in peripheral blood of melanoma patients.
Melanoma
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor.
Melanoma
Safety and efficacy of tyrosinase inhibition of Paeonia suffruticosa Andrews extracts on human melanoma cells.
Melanoma
Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma.
Melanoma
Safety assessment, biological effects, and mechanisms of Myrica rubra fruit extract for anti-melanogenesis, anti-oxidation, and free radical scavenging abilities on melanoma cells.
Melanoma
Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma - a retrospective study.
Melanoma
Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport.
Melanoma
SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma.
Melanoma
Selective cytotoxicity of hydroquinone for melanocyte-derived cells is mediated by tyrosinase activity but independent of melanin content.
Melanoma
Selective in vivo accumulation of N-acetyl-4-S-cysteaminylphenol in B16F10 murine melanoma and enhancement of its in vitro and in vivo antimelanoma effect by combination of buthionine sulfoximine.
Melanoma
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Melanoma
Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression.
Melanoma
Selective inhibition of growth and respiration of melanomas by tyrosinase inhibitors.
Melanoma
Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymically generated dopaquinone.
Melanoma
SELECTIVITY AND EFFICIENCY OF LATE TRANSGENE EXPRESSION BY TRANSCRIPTIONALLY TARGETED ONCOLYTIC ADENOVIRUSES ARE DEPENDENT ON THE TRANSGENE INSERTION STRATEGY.
Melanoma
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
Melanoma
Sentinel node biopsies in melanoma patients: a protocol for accurate, efficient, and cost-effective analysis by preselection for immunohistochemistry on the basis of Tyr-PCR.
Melanoma
Separation and characterization of multiple forms of tyrosinase from mouse melanoma.
Melanoma
Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression.
Melanoma
Serial follow-up and the prognostic significance of reverse transcriptase-polymerase chain reaction--staged sentinel lymph nodes from melanoma patients.
Melanoma
Serum and substratum-dependent coupled loss of differentiated and tumorigenic phenotypes in B16-conv melanoma cells.
Melanoma
Serum protein s-100 predicts clinical outcome in patients with melanoma treated with adjuvant interferon--comparison with tyrosinase rt-PCR.
Melanoma
Serum tyrosinase in malignant disease, its activity, and the electrophoretic patterns of the enzyme as carried by immunoglobulins'.
Melanoma
Serum tyrosine hydroxylase activity is increased in melanoma patients. An ROC curve analysis.
Melanoma
Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells.
Melanoma
Simultaneous analysis of tyrosinase mRNA and markers of tyrosinase activity in the blood of patients with metastatic melanoma.
Melanoma
Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor.
Melanoma
Simultaneous transduction of B7-1 and IL-2 genes into human melanoma cells to be used as vaccine: enhancement of stimulatory activity for autologous and allogeneic lymphocytes.
Melanoma
Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma.
Melanoma
Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients.
Melanoma
Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system.
Melanoma
Skin delivery of resveratrol encapsulated lipidic formulation for melanoma chemoprevention.
Melanoma
Skin resistance to UVB-induced oxidative stress and hyperpigmentation by the topical use of Lactobacillus helveticus NS8-fermented milk supernatant.
Melanoma
Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber.
Melanoma
Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell Autoimmunity toward Pigmented Cells by Tyrosinase Haptenation and Melanosome Autophagy.
Melanoma
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.
Melanoma
Solubilization and activation of mammalian melanoma particulate tyrosinase by lipase digestion.
Melanoma
Solubilizing effect of Trition X-100 on melanosome tyrosinase in hamster pigmented melanoma.
Melanoma
Sorafenib induces pigmentation via the regulation of ?-catenin signalling pathway in melanoma cells.
Melanoma
Specific Central Memory T Cells in the Bone Marrow of Patients Immunized Against Tyrosinase Peptides.
Melanoma
Specific inhibition by antityrosinase antibodies of tyrosinase-mediated melanogenesis.
Melanoma
Specific tyrosinases associated with melanoma replicative senescence and melanogenesis.
Melanoma
Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies.
Melanoma
Spontaneous T cell responses to melanoma differentiation antigens from melanoma patients and healthy subjects.
Melanoma
STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
Melanoma
Stem cell marker nestin expression in peripheral blood of patients with melanoma.
Melanoma
Stimulation by ionophores of tyrosinase activity of mouse melanoma cells in culture.
Melanoma
Stimulation of Cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle.
Melanoma
Stimulation of melanogenesis by nordihydroguaiaretic Acid in human melanoma cells.
Melanoma
Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins.
Melanoma
Stimulation of tyrosinase activity and melanin formation of cultured melanoma cells by serum deprivation alone or in combination with dibutyryl cyclic AMP and theophylline.
Melanoma
Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents.
Melanoma
Structural insight with mutational impact on tyrosinase and PKC-? interaction from Homo sapiens: Molecular modeling and docking studies for melanogenesis, albinism and increased risk for melanoma.
Melanoma
Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region.
Melanoma
Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.
Melanoma
Structural toxicity relationship of 4-alkoxyphenols' cytotoxicity towards murine B16-F0 melanoma cell line.
Melanoma
Structural/functional relationships between internal and external MSH receptors: modulation of expression in Cloudman melanoma cells by UVB radiation.
Melanoma
Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.
Melanoma
Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols.
Melanoma
Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis.
Melanoma
Substrate-Photocaged Enzymatic Fluorogenic Probe Enabling Sequential Activation for Light-Controllable Monitoring of Intracellular Tyrosinase Activity.
Melanoma
Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.
Melanoma
Sulfur containing tyrosine analogs can cause selective melanocytotoxicity involving tyrosinase-mediated apoptosis.
Melanoma
Suppression of C8161 melanoma metastatic ability by chromosome 6 induces differentiation-associated tyrosinase and decreases proliferation on adhesion-restrictive substrates mediated by overexpression of p21WAF1 and down-regulation of bcl-2 and cyclin D3.
Melanoma
Suppression of melanoma cell tyrosinase activity and tumorigenicity after incorporation of bromouracil for one or two cell divisions.
Melanoma
Suppression of pigmentation in mouse melanoma cells by 5-bromodeoxyuridine: effects on tyrosinase activity and melanosome formation.
Melanoma
Suppression of Pigmentation in Mouse Melanoma Cells by 5-Bromodeoxyuridine: Effects on Tyrosinase Activity.
Melanoma
Suppression of tyrosinase gene expression by bromodeoxyuridine in Syrian hamster melanoma cells is not due to its incorporation into upstream or coding sequences of the tyrosinase gene.
Melanoma
Syntheses of arbutin-alpha-glycosides and a comparison of their inhibitory effects with those of alpha-arbutin and arbutin on human tyrosinase.
Melanoma
Synthesis and actions of a melanotropin conjugate, Ac-[Nle4, Glu(gamma-4'-hydroxyanilide)5, D-Phe7]alpha-MSH4-10-NH2, on melanocytes and melanoma cells in vitro.
Melanoma
Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: novel tyrosinase inhibitors.
Melanoma
Synthesis and biological actions of highly potent and prolonged acting biotin-labeled melanotropins.
Melanoma
Synthesis and biological activities of fatty acid conjugates of a cyclic lactam alpha-melanotropin.
Melanoma
Synthesis and biological evaluation of N-aryl-2-phenyl-hydrazinecarbothioamides: Experimental and theoretical analysis on tyrosinase inhibition and interaction with HSA.
Melanoma
Synthesis and Biological Evaluation of the Anti-Melanogenesis Effect of Coumaric and Caffeic Acid-Conjugated Peptides in Human Melanocytes.
Melanoma
Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines.
Melanoma
Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in ?-MSH-stimulated B16F10 melanoma cells.
Melanoma
Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK.
Melanoma
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.
Melanoma
Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.
Melanoma
T cell immune function in tumor, skin and peripheral blood of advanced stage melanoma patients: implications for immunotherapy.
Melanoma
T cell immune responses against melanoma and melanocytes in cancer and autoimmunity.
Melanoma
T cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing.
Melanoma
T-Cell Mediated Immune Responses Induced in ret Transgenic Mouse Model of Malignant Melanoma.
Melanoma
T-cell responses against tyrosinase 368-376(370D) peptide in HLA*A0201+ melanoma patients: randomized trial comparing incomplete Freund's adjuvant, granulocyte macrophage colony-stimulating factor, and QS-21 as immunological adjuvants.
Melanoma
Targeting Melanoma-Initiating Cells by Caffeine: In Silico and In Vitro Approaches.
Melanoma
Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells.
Melanoma
Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences.
Melanoma
The activation of melanogenesis by p-CREB and MITF signaling with extremely low-frequency electromagnetic fields on B16F10 melanoma.
Melanoma
The amphibian melanization inhibiting factor (MIF) blocks the alpha-MSH effect on mouse malignant melanocytes.
Melanoma
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
Melanoma
The clinical significance of antityrosinase antibodies in melanoma and related hypopigmentary lesions.
Melanoma
The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity.
Melanoma
The cytotoxicity of cysteinylcatechols and related compounds to human melanoma cells in vitro.
Melanoma
The detection of circulating melanoma cells correlates with tumour thickness and ulceration but is not predictive of metastasis for patients with primary melanoma.
Melanoma
The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction.
Melanoma
The detection of tyrosinase mRNA in peripheral blood samples is unlikely to aid in the management of patients with localised malignant melanoma.
Melanoma
The detection of tyrosinase mRNA in the peripheral blood of stage I melanoma patients is not of clinical relevance in predicting metastasis risk and survival.
Melanoma
The detection of tyrosinase-specific mRNA in bone marrow is not more sensitive than in blood for the demonstration of micrometastatic melanoma.
Melanoma
The development of optimal pathological assessment of sentinel lymph nodes for melanoma.
Melanoma
The effect of antisense tyrosinase-related protein 1 on melanocytes and malignant melanoma cells.
Melanoma
The effect of chemo- and chemoimmunotherapy on the presence of circulating melanoma cells in peripheral blood. Preliminary results.
Melanoma
The effects of gp100 and tyrosinase peptide vaccinations on nevi in melanoma patients.
Melanoma
The effects of pro-opiomelanocortin peptides on cyclic AMP and tyrosinase in melanoma cells.
Melanoma
The existence of apotyrosinase in the cytosol of Harding-Passey mouse melanoma melanocytes and characteristics of enzyme reconstitution by Cu(II).
Melanoma
The expression of tyrosinase, tyrosinase-related proteins 1 and 2 (TRP1 and TRP2), the silver protein, and a melanogenic inhibitor in human melanoma cells of differing melanogenic activities.
Melanoma
The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor.
Melanoma
The glycosylation of tyrosinase in melanoma cells and the effect on antigen presentation.
Melanoma
The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers.
Melanoma
The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of ?-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes.
Melanoma
The in vivo antimelanoma effect of 4-S-cysteaminylphenol and its n-acetyl derivative.
Melanoma
The inhibition of early N-glycan processing targets TRP-2 to degradation in B16 melanoma cells.
Melanoma
The inhibitory effect of a synthetic compound, (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione (MHY498), on nitric oxide-induced melanogenesis.
Melanoma
The inhibitory effect of DL-alpha-tocopheryl ferulate in lecithin on melanogenesis.
Melanoma
The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells.
Melanoma
The inhibitory effect of silk sericin against ultraviolet-induced melanogenesis and its potential use in cosmeceutics as an anti-hyperpigmentation compound.
Melanoma
The involvement of histidine at the active site of Harding-Passey mouse melanoma tyrosinase.
Melanoma
The killing effect of 4-S-cysteaminylphenol, a newly synthesised melanin precursor, on B16 melanoma cell lines.
Melanoma
The melanotropic peptide, [Nle4,D-Phe7] alpha-MSH, stimulates human melanoma tyrosinase activity and inhibits cell proliferation.
Melanoma
The Metabolic Bioactivation of Caffeic Acid Phenethyl Ester Mediated by Tyrosinase Selectively Inhibits Glutathione S-Transferase.
Melanoma
The mixture of different parts of Nelumbo nucifera and two bioactive components inhibited tyrosinase activity and melanogenesis.
Melanoma
The natural yeast extract isolated by ethanol precipitation inhibits melanin synthesis by modulating tyrosinase activity and downregulating melanosome transfer.
Melanoma
The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly Expressed in spindled melanomas.
Melanoma
The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes.
Melanoma
The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
Melanoma
The Presence of Alpha-Synuclein in Skin from Melanoma and Patients with Parkinson's Disease.
Melanoma
The relationship between melanin production and lipofuscin formation in Tyrosinase gene knockout melanocytes using CRISPR/Cas9 system.
Melanoma
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.
Melanoma
The role of adenosine 3',5'-cyclic monophosphate in the density-dependent regulation of growth and tyrosinase activity of B-16 melanoma cells.
Melanoma
The role of sulfhydryl compounds in mammalian melanogenesis: the effect of cysteine and glutathione upon tyrosinase and the intermediates of the pathway.
Melanoma
The role of the detection of hematogenous micrometastasis in prostate adenocarcinoma and malignant melanoma by RT-PCR.
Melanoma
The role of the immune system in anti-tumour responses. Potential for drug therapy.
Melanoma
The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay.
Melanoma
The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function.
Melanoma
The Skin-Whitening Effects of Ectoine via the Suppression of ?-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes.
Melanoma
The Standardized Extract of Juniperus communis Alleviates Hyperpigmentation in Vivo HRM-2 Hairless Mice and in Vitro Murine B16 Melanoma Cells.
Melanoma
The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
Melanoma
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Melanoma
Theophylline and melanocyte-stimulating hormone: effects on uveal melanocytes of adult rhesus eyes.
Melanoma
Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma.
Melanoma
Therapeutic vaccine generated by electrofusion of dendritic cells and tumour cells.
Melanoma
Thermal activation and inactivation of melanin formation in vertebrate skins and melanomas.
Melanoma
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Melanoma
Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes.
Melanoma
Thymidylate synthase as a target enzyme for the melanoma-specific toxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol.
Melanoma
Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells.
Melanoma
Tissue-specific gene expression from Mo-MLV retroviral vectors with hybrid LTRs containing the murine tyrosinase enhancer/promoter.
Melanoma
Tissue-specific, cell cycle-regulated chimeric transcription factors for the targeting of gene expression to tumor cells.
Melanoma
TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD).
Melanoma
Traditional herbal prescription LASAP-C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish.
Melanoma
Traditional urinary cytology and tyrosinase RT-PCR in metastatic melanoma patients: correlation with clinical status.
Melanoma
Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells.
Melanoma
Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor.
Melanoma
Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells.
Melanoma
Transforming growth factor-beta1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1.
Melanoma
Transient expression of high molecular weight, heat sensitive, trypsin-resistant form of tyrosinase in B-16 melanoma cells.
Melanoma
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
Melanoma
Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation.
Melanoma
Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.
Melanoma
Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation.
Melanoma
Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management.
Melanoma
Tumor escape from immune recognition: loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6.
Melanoma
Tumor markers in peripheral blood of patients with malignant melanoma: multimarker RT-PCR versus a luminoimmunometric assay for S-100.
Melanoma
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines.
Melanoma
Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.
Melanoma
Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes.
Melanoma
TXM13 human melanoma cells: a novel source for the inhibition kinetics of human tyrosinase and for screening whitening agents.
Melanoma
Tyrosinase activities of cell-free extracts and living cells of cultured melanoma cells.
Melanoma
Tyrosinase activity and isoenzyme distribution corresponding to growth and regression of melanoma in Sinclair miniature swine.
Melanoma
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Melanoma
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma.
Melanoma
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Melanoma
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Melanoma
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient.
Melanoma
Tyrosinase exhibits lag at pH 6.8 under steady state concentrations of tyrosine and 3,4-dihydroxy phenyl alanine in melanoma tissue.
Melanoma
Tyrosinase expression and melanogenesis in melanotic and amelanotic B16 mouse melanoma cells.
Melanoma
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients.
Melanoma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Melanoma
Tyrosinase expression in the peripheral blood of stage III melanoma patients is associated with a poor prognosis: a clinical follow-up study of 110 patients.
Melanoma
Tyrosinase immunoreactivity in fine-needle aspiration samples of metastatic malignant melanoma.
Melanoma
Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.
Melanoma
Tyrosinase inhibition and anti-melanin generation effect of cinnamamide analogues.
Melanoma
Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts.
Melanoma
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Melanoma
Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry.
Melanoma
Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma.
Melanoma
Tyrosinase isoenzymes in mammalian melanocytes. 2. Differential activation by alpha-melanocyte-stimulating hormone.
Melanoma
Tyrosinase isoenzymes: two melanosomal tyrosinases with different kinetic properties and susceptibility to inhibition by calcium.
Melanoma
Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy.
Melanoma
Tyrosinase mRNA in blood of patients with melanoma treated with adjuvant interferon.
Melanoma
Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression.
Melanoma
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: a preliminary report.
Melanoma
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
Melanoma
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells.
Melanoma
Tyrosinase of hamster melanoma: its purification and estimation by radioimmunoassay.
Melanoma
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Melanoma
Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.
Melanoma
Tyrosinase transfection produces melanin synthesis and growth retardation in glioma cells.
Melanoma
Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.
Melanoma
Tyrosinase-induced free radical formation from VP-16,213: relationship to cytotoxicity.
Melanoma
Tyrosinase-mediated inhibition of in vitro leucine incorporation into mouse melanoma by 4-isopropylcatechol.
Melanoma
Tyrosinase-mediated melanogenesis in melanoma cells: Array comparative genome hybridization integrating proteomics and bioinformatics studies.
Melanoma
Tyrosine release and tyrosinase activity in amelanotic and melanotic malignant melanoma.
Melanoma
TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content.
Melanoma
Ultrasensitive Tyrosinase-Activated Turn-On Near-Infrared Fluorescent Probe with a Rationally Designed Urea Bond for Selective Imaging and Photodamage to Melanoma Cells.
Melanoma
Up-regulation of specific tyrosinase mRNAs in mouse melanomas with the c2j gene substituted for the wild-type tyrosinase allele: utilization in design of syngeneic immunotherapy models.
Melanoma
Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential.
Melanoma
Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety.
Melanoma
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Melanoma
Utility of tests for circulating melanoma cells in identifying patients who develop recurrent melanoma.
Melanoma
Vaccination with human tyrosinase DNA induces antibody responses in dogs with advanced melanoma.
Melanoma
Vaccination with melanoma lysate-pulsed dendritic cells, of patients with advanced colorectal carcinoma: report from a phase I study.
Melanoma
Vaccine-induced CD8+ T-cell responses to MAGE-3 correlate with clinical outcome in patients with melanoma.
Melanoma
Vasoactive intestinal peptide stimulates melanogenesis in B16F10 mouse melanoma cells via CREB/MITF/tyrosinase signaling.
Melanoma
VEGF-165 serum levels and tyrosinase expression in melanoma patients: correlation with the clinical course.
Melanoma
Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe.
Melanoma
Vitiliginous achromia with malignant melanoma. Tyrosinase activity and ultrastructural study of achromic and normal skin.
Melanoma
Vitis amurensis Ruprecht root inhibited ?-melanocyte stimulating hormone-induced melanogenesis in B16F10 cells.
Melanoma
Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening.
Melanoma
Whole exome sequencing identifies a novel pathogenic variation [p.(Gly194valfs*7)] in SLC45A2 in the homozygous state in multiple members of a family with oculocutaneous albinism in southern India.
Melanoma
Widespread occurrence of inhibitors of melanoma tyrosinase in plant and mammalian tissues.
Melanoma
Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used.
Melanoma
Wnt/?-catenin signaling inhibitor ICG-001 enhances pigmentation of cultured melanoma cells.
Melanoma
Xenogeneic murine tyrosinase DNA vaccine for malignant melanoma of the digit of dogs.
Melanoma
[8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways.
Melanoma
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
Melanoma
[Detection of circulating neoplastic cells by reverse transcriptase and polymerase chain reaction in melanoma]
Melanoma
[Detection of tyrosinase in normal and diseased pigment cells of the skin by means of radioactive tyrosine; original slide method; its applications in diagnosis of malignant melanoma.]
Melanoma
[Detection of tyrosinase mRNA using reverse transcription/polymerase chain reaction with fine needle punctures of melanoma metastases]
Melanoma
[Development of targeted chemoradiotherapy for malignant melanoma by exploitation of metabolic pathway]
Melanoma
[Disseminated melanoma cells in blood and bone marrow. Significance and detection by potential tumor markers]
Melanoma
[Effects of Xiaoyao Powder Extract in co-culture model of melanoma cells and keratinocytes on expression of tyrosinase and its related protein].
Melanoma
[Estrogen and progesterone receptors in malignant melanoma, benign pigmented nevi and basocellular epithelioma]
Melanoma
[Heterogeneity of tyrosinases isolated from rat skin, normal human skin, and human melanoma tumors]
Melanoma
[Immunologic analysis of tyrosinase in malignant melanoma, nevi and clinically normal skin]
Melanoma
[Isoenzymes of melanosomal tyrosinase isolated from transplanted hamster melanomas]
Melanoma
[Melanocyte-stimulating hormone induces growth of human malignant melanoma amelanotic cells with a change in cAMP, phosphatidylinositols, and inositol phosphate concentration]
Melanoma
[Molecular diagnostic detection of circulating tumor cells and their prognostic implications]
Melanoma
[Molecular diagnostics of malignant melanoma: molecular staging, minimal residual disease]
Melanoma
[Nle4, D-Phe7]-alpha-MSH: a superpotent melanotropin that "irreversibly" activates melanoma tyrosinase.
Melanoma
[Preliminary evaluation of a method for detection of individual malignant melanoma cells in peripheral blood while monitoring the course of the malignancy and its treatment]
Melanoma
[Study of the effect of progesterone on the tyrosinase activity of melanoma S 91 in mice]
Melanoma
[STUDY OF TYROSINASE ACTIVITY CHANGES IN EXPERIMENTAL MOUSE MELANOMA S 91 UNDER THE INFLUENCE OF TESTOSTERONE.]
Melanoma
[Synthesis and melanoma inhibiting properties of 4-alkylpyrocatechol-2-O-beta-D-glucopyranosiduronic acids and their esters]
Melanoma
[The detection of melanoma metastases in sentinel nodes by polymerase chain reaction]
Melanoma
[The effect of dinitrophenylation on the tyrosinase activity of extracts from human melanomas]
Melanoma
[The effects of intense pulsed light and 5-aminolevulinic acid on the cultured B16 marine melanoma cells]
Melanoma
[The sentinel lymph node in melanoma: utilization of molecular biology (RT-PCR) to detect occult metastases]
Melanoma
[Utilization of melanin precursors for experimental chemotherapy of malignant melanoma]
Melanoma, Amelanotic
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.
Melanoma, Amelanotic
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Melanoma, Amelanotic
Albinism and amelanotic melanoma: occurrence in a child with positive test results for tyrosinase.
Melanoma, Amelanotic
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands.
Melanoma, Amelanotic
Amelanotic melanoma: a detailed morphologic analysis with clinicopathologic correlation of 75 cases.
Melanoma, Amelanotic
Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells.
Melanoma, Amelanotic
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Melanoma, Amelanotic
Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis.
Melanoma, Amelanotic
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs.
Melanoma, Amelanotic
Dermoscopy, reflectance confocal microscopy and histopathology of an amelanotic melanoma from an individual heterozygous for MC1R and tyrosinase variant alleles.
Melanoma, Amelanotic
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy.
Melanoma, Amelanotic
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.
Melanoma, Amelanotic
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma.
Melanoma, Amelanotic
Effects of actinomycin D and cycloheximide on the increase in tyrosinase activity of hamster amelanotic melanoma cells in vitro.
Melanoma, Amelanotic
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma.
Melanoma, Amelanotic
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity.
Melanoma, Amelanotic
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: Effects of altering intracellular pH and pink-eyed dilution gene expression.
Melanoma, Amelanotic
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
Melanoma, Amelanotic
Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
Melanoma, Amelanotic
Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcellular compartments in amelanotic and melanomas.
Melanoma, Amelanotic
L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism.
Melanoma, Amelanotic
L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells.
Melanoma, Amelanotic
Molecular and biological control of melanogenesis through tyrosinase genes and intrinsic and extrinsic regulatory factors.
Melanoma, Amelanotic
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells.
Melanoma, Amelanotic
Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells.
Melanoma, Amelanotic
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.
Melanoma, Amelanotic
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene.
Melanoma, Amelanotic
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Melanoma, Amelanotic
Transient expression of high molecular weight, heat sensitive, trypsin-resistant form of tyrosinase in B-16 melanoma cells.
Melanoma, Amelanotic
Translation rate of human tyrosinase determines its N-linked glycosylation level.
Melanoma, Amelanotic
Tyrosinase activity in primary cell culture of amelanotic melanoma cells.
Melanoma, Amelanotic
Tyrosinase and gamma-glutamyl transpeptidase in 5-s-cysteinyldopa genesis within melanotic and amelanotic melanomas.
Melanoma, Amelanotic
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport.
Melanoma, Amelanotic
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Melanoma, Amelanotic
Tyrosinase gene transcription and its control by melanogenic inhibitors.
Melanoma, Amelanotic
Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections.
Melanoma, Amelanotic
[Ultrastructural studies of the occurrence of tyrosinase in transplantable amelanotic melanoma in Syrian hamster]
Melanoma, Experimental
3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells.
Melanoma, Experimental
A chelating derivative of alpha-melanocyte stimulating hormone as a potential imaging agent for malignant melanoma.
Melanoma, Experimental
A dominant negative mutant of microphthalmia transcription factor (MITF) lacking two transactivation domains suppresses transcription mediated by wild type MITF and a hyperactive MITF derivative.
Melanoma, Experimental
A new 2-imino-1,3-thiazoline derivative, KHG22394, inhibits melanin synthesis in mouse B16 melanoma cells.
Melanoma, Experimental
A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells.
Melanoma, Experimental
A novel melanin inhibitor: hydroperoxy traxastane-type triterpene from flowers of Arnica montana.
Melanoma, Experimental
A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells.
Melanoma, Experimental
A safe, effective in vivo gene therapy for melanoma using tyrosinase promoter-driven cytosine deaminase gene.
Melanoma, Experimental
Acanthoic acid inhibits melanogenesis through tyrosinase downregulation and melanogenic gene expression in B16 melanoma cells.
Melanoma, Experimental
Acetoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase.
Melanoma, Experimental
Aglycone of Rh4 inhibits melanin synthesis in B16 melanoma cells: possible involvement of the protein kinase A pathway.
Melanoma, Experimental
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Melanoma, Experimental
Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis.
Melanoma, Experimental
Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules.
Melanoma, Experimental
Anti-tyrosinase antibodies participate in the immune response to vaccination with anti-idiotypic antibodies mimicking the high-molecular-weight melanoma-associated antigen.
Melanoma, Experimental
Antimelanogenic Activity of 3,4-Dihydroxyacetophenone: Inhibition of Tyrosinase and MITF.
Melanoma, Experimental
Antioxidant and antimelanogenic activities of polyamine conjugates from corn bran and related hydroxycinnamic acids.
Melanoma, Experimental
Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa.
Melanoma, Experimental
Antioxidative and skin-whitening effect of an aqueous extract of Salicornia herbacea.
Melanoma, Experimental
Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells.
Melanoma, Experimental
Biological activity, binding, and metabolic fate of Ac-[Nle4, D-Phe7]alpha-MSH4-11NH2 with the F1 variant of B16 melanoma cells.
Melanoma, Experimental
BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes.
Melanoma, Experimental
Calcium plays a complex role in the regulation of melanogenesis in murine B16 melanoma cells.
Melanoma, Experimental
Cell adhesion regulates melanoma specific differentiation and interactions with the 3' region of the tyrosinase gene.
Melanoma, Experimental
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Melanoma, Experimental
Chemical components of Hyssopus seravshanicus: antioxidant activity, activations of melanogenesis and tyrosinase, and quantitative determination by UPLC-DAD.
Melanoma, Experimental
Cinnamomum cassia Essential Oil Inhibits ?-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells.
Melanoma, Experimental
Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in cloudman S91 melanoma cells after ultraviolet-irradiation.
Melanoma, Experimental
Curcumin-like diarylpentanoid analogues as melanogenesis inhibitors.
Melanoma, Experimental
Cyclohexanediol Bis-Ethylhexanoate Inhibits Melanogenesis of Murine B16 Melanoma and UV-Induced Pigmentation in Human Skin.
Melanoma, Experimental
Cytotoxicity of 4-hydroxyanisole and tyrosinase activity in variant cell lines of B16 melanoma.
Melanoma, Experimental
Depigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalent.
Melanoma, Experimental
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.
Melanoma, Experimental
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Melanoma, Experimental
Different susceptibilities of melanoma cells to retinoic acid-induced changes in melanotic expression.
Melanoma, Experimental
Dihydro-1,4-benzothiazine-6,7-dione, the ultimate toxic metabolite of 4-S-cysteaminylphenol and 4-S-cysteaminylcatechol.
Melanoma, Experimental
Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.
Melanoma, Experimental
EFFECT OF FUCOIDAN ON B16 MURINE MELANOMA CELL MELANIN FORMATION AND APOPTOSIS.
Melanoma, Experimental
Effect of heterocyclic pyrimidine compounds on UVB-induced cell damage in human keratinocytes and on melanogenesis in mouse B16 cells.
Melanoma, Experimental
Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.
Melanoma, Experimental
Effect of Pinus radiate bark extracts with different molecular weight distributions on cell growth of NIH/3T3 fibroblasts and dendrite retraction of B16 melanoma cells
Melanoma, Experimental
Effect of simultaneous administration of vitamin C, L-cysteine and vitamin E on the melanogenesis.
Melanoma, Experimental
Effect of testosterone on imidazole-induced tyrosinase expression in B16 melanoma cell culture.
Melanoma, Experimental
Effects of Wnt-10b on proliferation and differentiation of murine melanoma cells.
Melanoma, Experimental
Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications.
Melanoma, Experimental
Evaluation of Antioxidant and Anti-Melanogenic Activity of Different Extracts of Aerial Parts of N. Sintenisii in Murine Melanoma B16F10 Cells.
Melanoma, Experimental
Evaluation of depigmenting activity by 8-hydroxydaidzein in mouse b16 melanoma cells and human volunteers.
Melanoma, Experimental
Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis.
Melanoma, Experimental
False dopa reaction in studies of mammalian tyrosinase: some characteristics and precautions.
Melanoma, Experimental
Folium nelumbinis (Lotus leaf) volatile-rich fraction and its mechanisms of action against melanogenesis in B16 cells.
Melanoma, Experimental
Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells.
Melanoma, Experimental
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Melanoma, Experimental
Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia.
Melanoma, Experimental
Glycosidic inhibitors of melanogenesis from leaves of Passiflora edulis.
Melanoma, Experimental
Hepatocyte growth factor/scatter factor and hepatocytes are potent downregulators of tyrosinase expression in B16 melanoma cells.
Melanoma, Experimental
High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex.
Melanoma, Experimental
Hot-water extracts from adzuki beans (Vigna angularis) stimulate not only melanogenesis in cultured mouse B16 melanoma cells but also pigmentation of hair color in C3H mice.
Melanoma, Experimental
Hydrolysates of citrus plants stimulate melanogenesis protecting against UV-induced dermal damage.
Melanoma, Experimental
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.
Melanoma, Experimental
In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition.
Melanoma, Experimental
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Melanoma, Experimental
Inhibition of melanogenesis by BMY-28565, a novel compound depressing tyrosinase activity in B16 melanoma cells.
Melanoma, Experimental
Inhibition of N-glycan processing in B16 melanoma cells results in inactivation of tyrosinase but does not prevent its transport to the melanosome.
Melanoma, Experimental
Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol.
Melanoma, Experimental
Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.
Melanoma, Experimental
Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis.
Melanoma, Experimental
Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells.
Melanoma, Experimental
Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.
Melanoma, Experimental
Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis.
Melanoma, Experimental
Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis.
Melanoma, Experimental
Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities.
Melanoma, Experimental
Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis.
Melanoma, Experimental
Inhibitory effects of Na7PMo11CuO40 on mushroom tyrosinase and melanin formation and its antimicrobial activities.
Melanoma, Experimental
Inulavosin, a melanogenesis inhibitor, leads to mistargeting of tyrosinase to lysosomes and accelerates its degradation.
Melanoma, Experimental
Investigation of the regulation of pigmentation in alpha-melanocyte-stimulating hormone responsive and unresponsive cultured B16 melanoma cells.
Melanoma, Experimental
Involvement of calpain in melanogenesis of mouse B16 melanoma cells.
Melanoma, Experimental
Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.
Melanoma, Experimental
Iodination of beta-melanotropin. Time course analysis of reaction mixtures by high pressure liquid chromatography and characterization of biologically active mono- and diiodo-beta-melanotropin.
Melanoma, Experimental
Isolation and characterization of variant cDNAs encoding mouse tyrosinase.
Melanoma, Experimental
Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.
Melanoma, Experimental
Limonoids from Azadirachta indica var. siamensis Extracts and Their Cytotoxic and Melanogenesis-Inhibitory Activities.
Melanoma, Experimental
Lucidone, a novel melanin inhibitor from the fruit of Lindera erythrocarpa Makino.
Melanoma, Experimental
Mechanism of pigmentation by minocycline in murine B16 melanoma cells.
Melanoma, Experimental
Mechanisms of melanogenesis inhibition by 2,5-dimethyl-4-hydroxy-3(2H)-furanone.
Melanoma, Experimental
Melaleuca quinquenervia essential oil inhibits ?-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells.
Melanoma, Experimental
Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells.
Melanoma, Experimental
Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan.
Melanoma, Experimental
Melanogenesis inhibitory activities of diarylheptanoids from Alnus hirsuta Turcz in B16 mouse melanoma cell.
Melanoma, Experimental
Melanogenesis inhibitory activity of components from Salam leaf (Syzygium polyanthum) extract.
Melanoma, Experimental
Melanogenesis Inhibitory Activity of Sesquiterpenes from Canarium ovatum Resin in Mouse B16 Melanoma Cells.
Melanoma, Experimental
Melanogenesis-inhibitory activities of limonoids and tricyclic diterpenoids from Azadirachta indica.
Melanoma, Experimental
Melanogenesis-inhibitory activity of aromatic glycosides from the stem bark of Acer buergerianum.
Melanoma, Experimental
Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.
Melanoma, Experimental
Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing.
Melanoma, Experimental
N-Alkylamides from Piper longum L. and their stimulative effects on the melanin content and tyrosinase activity in B16 melanoma cells.
Melanoma, Experimental
New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics.
Melanoma, Experimental
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Melanoma, Experimental
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
Melanoma, Experimental
Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.
Melanoma, Experimental
Over-expression of MSG1 transcriptional co-activator increases melanin in B16 melanoma cells: a possible role for MSG1 in melanogenesis.
Melanoma, Experimental
p21-Activated Kinase 4 Critically Regulates Melanogenesis via Activation of the CREB/MITF and ?-Catenin/MITF Pathways.
Melanoma, Experimental
Partial characterization of IR-alpha-MSH peptides found in melanoma tumors.
Melanoma, Experimental
Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities.
Melanoma, Experimental
Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway.
Melanoma, Experimental
Poly-?-glutamate from Bacillus subtilis inhibits tyrosinase activity and melanogenesis.
Melanoma, Experimental
Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.
Melanoma, Experimental
Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study.
Melanoma, Experimental
Pyrroloquinoline quinone (PQQ) inhibits the expression of tyrosinase mRNA by alpha-melanocyte stimulating hormone in murine B16 melanoma cells.
Melanoma, Experimental
Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells.
Melanoma, Experimental
Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
Melanoma, Experimental
Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.
Melanoma, Experimental
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Melanoma, Experimental
Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine.
Melanoma, Experimental
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells.
Melanoma, Experimental
Sesamin induces melanogenesis by microphthalmia-associated transcription factor and tyrosinase up-regulation via cAMP signaling pathway.
Melanoma, Experimental
Soluble Pearl Extract provides effective skin lightening by antagonizing endothelin.
Melanoma, Experimental
Stimulation of the receptor for melanocyte-stimulating hormone by retinoic acid.
Melanoma, Experimental
Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents.
Melanoma, Experimental
Structure-activity relationship of prenyl-substituted polyphenols from Artocarpus heterophyllus as inhibitors of melanin biosynthesis in cultured melanoma cells.
Melanoma, Experimental
Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates.
Melanoma, Experimental
Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues.
Melanoma, Experimental
Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences.
Melanoma, Experimental
The anti-melanogenic effect of pycnogenol by its anti-oxidative actions.
Melanoma, Experimental
The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells.
Melanoma, Experimental
The effects of Salacia reticulata on anti-cellular oxidants and melanogenesis inhibition in alpha-MSH-stimulated and UV irradiated B16 melanoma cells.
Melanoma, Experimental
The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.
Melanoma, Experimental
The tyrosinase activity of melanosomes from the Harding-Passey melanoma: the absence of a peroxidase component in vitro.
Melanoma, Experimental
Topical Application of gamma-Tocopherol Derivative Prevents UV-Induced Skin Pigmentation.
Melanoma, Experimental
Transforming growth factor beta1 mediates hypopigmentation of B16 mouse melanoma cells by inhibition of melanin formation and melanosome maturation.
Melanoma, Experimental
Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.
Melanoma, Experimental
Tyrosinase activity in the cellular fractions of Harding-Passey melanoma.
Melanoma, Experimental
Tyrosinase maturation and pigment expression in B16 melanoma: relation to theophylline treatment and intracellular cyclic AMP.
Melanoma, Experimental
Unequal nuclear Sp1/GC box DNA binding activity distinguishes proliferating from differentiated senescent or apoptotic cells.
Melanoma, Experimental
Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes.
Melanoma, Experimental
Whitening activity of luteolin related to the inhibition of cAMP pathway in alpha-MSH-stimulated B16 melanoma cells.
Melanoma, Experimental
Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes.
Melanoma, Experimental
[Inhibitory effect of arbutin on melanogenesis--biochemical study using cultured B16 melanoma cells]
Melanoma, Experimental
[Investigation of tyrosinase activity and phospholipid composition in Harding-Passey melanoma microsomal fraction]
Melanoma, Experimental
[Study on tyrosinase activity in experimental melanoma S 91 in mice and its variations on the effect of estradiol]
Melanoma, Experimental
[The effects of intense pulsed light and 5-aminolevulinic acid on the cultured B16 marine melanoma cells]
Melanosis
3-hydroxycoumarin loaded vesicles for recombinant human tyrosinase inhibition in topical applications.
Melanosis
A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women.
Melanosis
A split-face, double-blind, randomized and placebo-controlled pilot evaluation of a novel oligopeptide for the treatment of recalcitrant melasma.
Melanosis
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Melanosis
Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
Melanosis
Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders.
Melanosis
Combined use of two formulations containing diacetyl boldine, TGF-?1 biomimetic oligopeptide-68 with other hypopigmenting/exfoliating agents and sunscreen provides effective and convenient treatment for facial melasma. Either is equal to or is better than 4% hydroquinone on normal skin.
Melanosis
Effect of dicarboxylic acids on normal human melanocytes in dispersed tissue culture.
Melanosis
Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.
Melanosis
Efficacy and safety of liposome-encapsulated 4-n-butylresorcinol 0.1% cream for the treatment of melasma: a randomized controlled split-face trial.
Melanosis
Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.
Melanosis
Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways.
Melanosis
Generalized melanosis secondary to malignant melanoma. Report of a case with serum and tissue tyrosinase studies.
Melanosis
Histopathological study of the treatment of melasma lesions using a low-fluence Q-switched 1064-nm neodymium:yttrium-aluminium-garnet laser.
Melanosis
Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs.
Melanosis
Hypopigmenting Activity of Bisabolangelone Isolated from Angelica koreana Maxim. in alpha-Melanocyte Stimulating Hormone-Activated B16 or Melan-a Cells.
Melanosis
In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds.
Melanosis
Inhibition of Melanosis in Whiteleg Shrimp (Litopenaeus vannamei) during Refrigerated Storage Using Extracts of Different Avocado (Persea americana Mill.) By-Products.
Melanosis
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.
Melanosis
Kojic Acid vis-a-vis its Combinations with Hydroquinone and Betamethasone Valerate in Melasma: A Randomized, Single Blind, Comparative Study of Efficacy and Safety.
Melanosis
Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid.
Melanosis
Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors.
Melanosis
NF-?B/AP-1-targeted inhibition of macrophage-mediated inflammatory responses by depigmenting compound AP736 derived from natural 1,3-diphenylpropane skeleton.
Melanosis
Purification and determination of the chemical structure of the tyrosinase inhibitor produced by Trichoderma viride strain H1-7 from a marine environment.
Melanosis
Recovery of pigmentation following selective photothermolysis in adult zebrafish skin: clinical implications for laser toning treatment of melasma.
Melanosis
The Anti-melanogenesis Activities of Some Selected Red Macroalgae from Northern Coasts of the Persian Gulf.
Melanosis
Treatment of mild to moderate facial melasma with the Lumixyl topical brightening system.
Memory Disorders
Effects of probiotic fermentation on the enhancement of biological and pharmacological activities of Codonopsis lanceolata extracted by high pressure treatment.
Menkes Kinky Hair Syndrome
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Metrorrhagia
Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype is Cell-Autonomous.
Microphthalmos
A distinctive translocation carcinoma of the kidney; "rosette forming," t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases.
Microphthalmos
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells.
Microphthalmos
alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome.
Microphthalmos
Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
Microphthalmos
Antimelanogenic Activity of 3,4-Dihydroxyacetophenone: Inhibition of Tyrosinase and MITF.
Microphthalmos
Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF.
Microphthalmos
Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.
Microphthalmos
Celecoxib as a Valuable Adjuvant in Cutaneous Melanoma Treated with Trametinib.
Microphthalmos
Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep.
Microphthalmos
Coordinate extinction of melanocyte-specific gene expression in hybrid cells.
Microphthalmos
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.
Microphthalmos
Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon.
Microphthalmos
Expression of tyrosinase and the tyrosinase related proteins in the Mitfvit (vitiligo) mouse eye: implications for the function of the microphthalmia transcription factor.
Microphthalmos
Flavonoid Glycosides from Ziziphus jujuba var. inermis (Bunge) Rehder Seeds Inhibit ?-Melanocyte-Stimulating Hormone-Mediated Melanogenesis.
Microphthalmos
Growth regulatory proteins that repress differentiation markers in melanocytes also downregulate the transcription factor microphthalmia.
Microphthalmos
Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene.
Microphthalmos
Identification of a novel microRNA important for melanogenesis in alpaca (Vicugna pacos).
Microphthalmos
Immunohistochemical analysis of BRAF(V600E) expression of primary and metastatic melanoma and comparison with mutation status and melanocyte differentiation antigens of metastatic lesions.
Microphthalmos
Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas.
Microphthalmos
Immunohistochemical diagnosis of canine oral amelanotic melanocytic neoplasms.
Microphthalmos
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Microphthalmos
Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas.
Microphthalmos
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
Microphthalmos
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.
Microphthalmos
Induction of "antigen silencing" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression.
Microphthalmos
Inhibition of melanin production by a combination of Siberian larch and pomegranate fruit extracts.
Microphthalmos
Inhibition of melanogenic activity by 4,4'-dihydroxybiphenyl in melanoma cells.
Microphthalmos
Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation.
Microphthalmos
Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator.
Microphthalmos
Melanoma genomics reveals signatures of sensitivity to bio- and targeted therapies.
Microphthalmos
Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.
Microphthalmos
Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes.
Microphthalmos
MicroRNA-21a-5p Functions on the Regulation of Melanogenesis by Targeting Sox5 in Mouse Skin Melanocytes.
Microphthalmos
Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes.
Microphthalmos
MUM-1 Expression Differentiates Tumors in the PEComa Family From Clear Cell Sarcoma and Melanoma.
Microphthalmos
Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins.
Microphthalmos
Proanthocyanidins isolated from the leaves of Photinia × fraseri block the cell cycle and induce apoptosis by inhibiting tyrosinase activity in melanoma cells.
Microphthalmos
Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors.
Microphthalmos
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Microphthalmos
Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.
Microphthalmos
Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system.
Microphthalmos
TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes.
Microphthalmos
The mouse tyrosinase gene. Promoter modulation by positive and negative regulatory elements.
Microphthalmos
The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
Microphthalmos
The role of sex-determining region Y-box 6 in melanogenesis in alpaca melanocytes.
Microphthalmos
trans-Caffeic acid stearyl ester from Paeonia suffruticosa inhibits melanin synthesis by cAMP-mediating down-regulation of ?-melanocyte-stimulating hormone-stimulated melanogenesis signaling pathway in B16 cells.
Microphthalmos
Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor.
Microphthalmos
Tyrosine levels regulate the melanogenic response to alpha-melanocyte-stimulating hormone in human melanocytes: implications for pigmentation and proliferation.
Microphthalmos
Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases.
Microphthalmos
Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells.
Multiple Endocrine Neoplasia
[Clinical manifestations, therapeutic response to tyrosinase inhibitor and RET gene activating mutation in a patient with multiple endocrine neoplasia 2B].
Myasthenia Gravis
New Insights into the Exploitation of Vitis vinifera L. cv. Aglianico Leaf Extracts for Nutraceutical Purposes.
Mycoses
The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function.
Mycosis Fungoides
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Myocardial Infarction
Using tyrosinase as a tri-modality reporter gene to monitor transplanted stem cells in acute myocardial infarction.
Myopia
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Myopia
Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs.
Neoplasm Metastasis
A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation.
Neoplasm Metastasis
A Fluorescent Probe for Early Detection of Melanoma and Its Metastasis by Specifically Imaging Tyrosinase Activity in a Mouse Model.
Neoplasm Metastasis
A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.
Neoplasm Metastasis
Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy.
Neoplasm Metastasis
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Neoplasm Metastasis
Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.
Neoplasm Metastasis
Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.
Neoplasm Metastasis
Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.
Neoplasm Metastasis
Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma.
Neoplasm Metastasis
Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens.
Neoplasm Metastasis
Detection of disseminated melanoma cells by reverse-transcription - polymerase chain reaction.
Neoplasm Metastasis
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Neoplasm Metastasis
Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.
Neoplasm Metastasis
Detection of regional melanoma metastases by ultrasound B-scan, cytology or tyrosinase RT-PCR of fine-needle aspirates.
Neoplasm Metastasis
Detection of tyrosinase mRNA by reverse transcription-polymerase chain reaction in melanoma sentinel nodes.
Neoplasm Metastasis
Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma.
Neoplasm Metastasis
Ex vivo derived primary melanoma cells: implications for immunotherapeutic vaccines.
Neoplasm Metastasis
Examination of regional lymph nodes by sentinel node biopsy and molecular analysis provides new staging facilities in primary cutaneous melanoma.
Neoplasm Metastasis
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Neoplasm Metastasis
Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients.
Neoplasm Metastasis
Expression of melanocyte differentiation antigens and ki-67 in nodal nevi and comparison of ki-67 expression with metastatic melanoma.
Neoplasm Metastasis
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Neoplasm Metastasis
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Neoplasm Metastasis
Hematogenous spread of malignant melanoma cells in different stages of disease.
Neoplasm Metastasis
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Neoplasm Metastasis
Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies?
Neoplasm Metastasis
High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.
Neoplasm Metastasis
High homogeneity of MAGE, BAGE, GAGE, tyrosinase and Melan-A/MART-1 gene expression in clusters of multiple simultaneous metastases of human melanoma: implications for protocol design of therapeutic antigen-specific vaccination strategies.
Neoplasm Metastasis
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo.
Neoplasm Metastasis
Lack of prognostic importance of reverse-transcriptase polymerase chain reaction detection of circulating messenger RNA in patients with melanoma.
Neoplasm Metastasis
MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases.
Neoplasm Metastasis
Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab.
Neoplasm Metastasis
Molecular detection of MART-1, tyrosinase and MIA in peripheral blood, lymph nodes and metastatic sites of stage III/IV melanoma patients.
Neoplasm Metastasis
Molecular staging of malignant melanoma: correlation with clinical outcome.
Neoplasm Metastasis
Multimarker Reverse Transcriptase-Polymerase Chain Reaction Assay in Lymphatic Drainage and Sentinel Node Tumor Burden.
Neoplasm Metastasis
No correlation of tyrosinase mRNA in bone marrow with prognosis of metastatic melanoma.
Neoplasm Metastasis
Partial characterization of IR-alpha-MSH peptides found in melanoma tumors.
Neoplasm Metastasis
Pathologic assessment of melanoma sentinel nodes: a role for molecular analysis using quantitative real-time reverse transcription-PCR for MART-1 and tyrosinase messenger RNA.
Neoplasm Metastasis
Polymerase chain reaction detection of melanoma cells in the circulation: relation to clinical stage, surgical treatment, and recurrence from melanoma.
Neoplasm Metastasis
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Neoplasm Metastasis
Prevention of an additional surgery for regional lymphadenectomy in melanoma: Rapid intraoperative immunostaining of sentinel lymph node imprint smears.
Neoplasm Metastasis
Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time.
Neoplasm Metastasis
Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients.
Neoplasm Metastasis
Prognostic significance of tyrosinase mRNA detected by nested RT-PCR in patients with malignant melanoma.
Neoplasm Metastasis
Reactivity to tyrosinase: expression in cancer (melanoma) and autoimmunity (vitiligo).
Neoplasm Metastasis
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
Neoplasm Metastasis
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Neoplasm Metastasis
Serial follow-up and the prognostic significance of reverse transcriptase-polymerase chain reaction--staged sentinel lymph nodes from melanoma patients.
Neoplasm Metastasis
Simultaneous analysis of tyrosinase mRNA and markers of tyrosinase activity in the blood of patients with metastatic melanoma.
Neoplasm Metastasis
Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies.
Neoplasm Metastasis
Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols.
Neoplasm Metastasis
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
Neoplasm Metastasis
The detection of tyrosinase mRNA in the peripheral blood of stage I melanoma patients is not of clinical relevance in predicting metastasis risk and survival.
Neoplasm Metastasis
The detection of tyrosinase-specific mRNA in bone marrow is not more sensitive than in blood for the demonstration of micrometastatic melanoma.
Neoplasm Metastasis
The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes.
Neoplasm Metastasis
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
Neoplasm Metastasis
[Detection of tyrosinase mRNA using reverse transcription/polymerase chain reaction with fine needle punctures of melanoma metastases]
Neoplasm Micrometastasis
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
Neoplasm Micrometastasis
Assessment of melanoma-initiating cell markers and conventional parameters in sentinel lymph nodes of malignant melanoma.
Neoplasm Micrometastasis
Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.
Neoplasm Micrometastasis
Detection of melanoma micrometastasis in sentinel nodes by reverse transcription-polymerase chain reaction correlates with tumor thickness and is predictive of micrometastatic disease in the lymph node basin.
Neoplasm Micrometastasis
Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods.
Neoplasm Micrometastasis
Detection of submicroscopic lymph node metastases with polymerase chain reaction in patients with malignant melanoma.
Neoplasm Micrometastasis
Expression of tyrosinase, MIA and MART-1 in sentinel lymph nodes of patients with malignant melanoma.
Neoplasm Micrometastasis
Highly sensitive multivariable assay detection of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes with melanoma micrometastases.
Neoplasm Micrometastasis
Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase.
Neoplasm Micrometastasis
Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction.
Neoplasm Micrometastasis
Limitations of the nested reverse transcriptase polymerase chain reaction on tyrosinase for the detection of malignant melanoma micrometastases in lymph nodes.
Neoplasm Micrometastasis
Lymph node micrometastases of cutaneous melanoma: increased sensitivity of molecular diagnosis in comparison to immunohistochemistry.
Neoplasm Micrometastasis
Mapping of occult melanoma micrometastases in the inguinal lymph node basin by immunohistochemistry and RT-PCR.
Neoplasm Micrometastasis
Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients.
Neoplasm Micrometastasis
Polymerase chain reaction and immunohistochemistry frequently detect occult melanoma cells in regional lymph nodes of melanoma patients.
Neoplasm Micrometastasis
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Neoplasm Micrometastasis
Prognostic significance of detecting micrometastases by tyrosinase RT/PCR in sentinel lymph node biopsies: lessons from 322 consecutive melanoma patients.
Neoplasm Micrometastasis
Sentinel lymph node: detection of micrometastases of melanoma in a molecular study.
Neoplasm, Residual
Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease.
Neoplasms
A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation.
Neoplasms
A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity.
Neoplasms
A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.
Neoplasms
A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.
Neoplasms
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
Neoplasms
A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells.
Neoplasms
A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.
Neoplasms
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
Neoplasms
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
Neoplasms
A survey of the humoral immune response of cancer patients to a panel of human tumor antigens.
Neoplasms
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes.
Neoplasms
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.
Neoplasms
Acute effects of two melanocytolytic agents, hydroquinone and beta-mercaptoethanolamine, upon tyrosinase activity and cyclic nucleotide levels in murine melanomas.
Neoplasms
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Neoplasms
Altered Morphology and Immunohistochemical Characteristics in Metastatic Malignant Melanoma After Therapy With Vemurafenib.
Neoplasms
Amelanotic melanoma: a detailed morphologic analysis with clinicopathologic correlation of 75 cases.
Neoplasms
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Neoplasms
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
Neoplasms
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Neoplasms
Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy.
Neoplasms
Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
Neoplasms
Analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates.
Neoplasms
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Neoplasms
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, ?-lactamase enzyme inhibition studies.
Neoplasms
Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis.
Neoplasms
Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma.
Neoplasms
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.
Neoplasms
Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines.
Neoplasms
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Neoplasms
Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanoma.
Neoplasms
Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase.
Neoplasms
Brightly colored pigmentation in lower vertebrates: wonder searching its mechanisms and significance in the context of phylogeny.
Neoplasms
CD4+ T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase.
Neoplasms
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.
Neoplasms
CD45/CD8 Myeloid Histioid Antigen and Plasma Cell Antibody Immune Response in a Case of Malignant Melanoma.
Neoplasms
Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method.
Neoplasms
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Neoplasms
Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase.
Neoplasms
Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.
Neoplasms
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Neoplasms
Circulating tyrosinase and MART-1 mRNA does not independently predict relapse or survival in patients with AJCC stage I-II melanoma.
Neoplasms
Clinical value of combined determination of plasma L-DOPA/tyrosine ratio, S100B, MIA and LDH in melanoma.
Neoplasms
Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.
Neoplasms
Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.
Neoplasms
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations.
Neoplasms
Comparison of the Sec and Tat secretion pathways for heterologous protein production by Streptomyces lividans.
Neoplasms
Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles.
Neoplasms
Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201.
Neoplasms
Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1.
Neoplasms
Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes.
Neoplasms
Correlation of positive RT-PCR for tyrosinase in peripheral blood of malignant melanoma patients with clinical stage, survival and other risk factors.
Neoplasms
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.
Neoplasms
CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases.
Neoplasms
Demonstration of cytoplasmic tyrosinase mRNA in tissue-cultured cells by reverse transcription (RT) in situ polymerase chain reaction (PCR) and RT PCR in situ hybridization.
Neoplasms
Dendritic cells containing apoptotic melanoma cells prime human CD8+ T cells for efficient tumor cell lysis.
Neoplasms
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.
Neoplasms
Desmoplastic melanoma of the head and neck: histopathologic and immunohistochemical study of 28 cases.
Neoplasms
Detection of circulating melanoma cells by specific amplification of tyrosinase complementary DNA is not a reliable tumor marker in melanoma patients: a clinical two-center study.
Neoplasms
Detection of early micrometastases in subcutaneous fat of primary malignant melanoma patients by identification of tyrosinase-mRNA.
Neoplasms
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Neoplasms
Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction.
Neoplasms
Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription-polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness.
Neoplasms
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Neoplasms
Detection of naturally processed and HLA-A1-presented melanoma T-cell epitopes defined by CD8(+) T-cells' release of granulocyte-macrophage colony-stimulating factor but not by cytolysis.
Neoplasms
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy.
Neoplasms
Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma.
Neoplasms
Detection of tyrosinase in living cells using an Enteromorpha Prolifera based fluorescent probe.
Neoplasms
Detection of tyrosinase mRNA in tumor tissue microdissections from classic Kaposi's sarcoma.
Neoplasms
Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs.
Neoplasms
Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center.
Neoplasms
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.
Neoplasms
Development of Immunologic Assays to Measure Response in Horses Vaccinated with Xenogeneic Plasmid DNA Encoding Human Tyrosinase
Neoplasms
Differentiation of new metastatic variants of B16 melanoma under different culture conditions.
Neoplasms
Differentiation-inducing and anti-proliferative activities of lupeol on canine melanoma cells.
Neoplasms
Does intensive histopathological workup by serial sectioning increase the detection of lymph node micrometastasis in patients with primary cutaneous melanoma?
Neoplasms
Down-regulation of tyrosinase mRNA levels in melanoma cells by tumor promoters and by insulin.
Neoplasms
Dual control of melanogenesis and melanoma growth: overview molecular to clinical level and the reverse.
Neoplasms
Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.
Neoplasms
Effect of theophyllin and isoproterenol on cAMP level in melanotic and amelanotic hamster melanomas.
Neoplasms
Effective Inhibition of Skin Cancer, Tyrosinase and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from Green Alga Haematococcus pluvialis.
Neoplasms
Effectiveness of 1alpha-hydroxyvitamin D2 in inhibiting tumor growth in a murine transgenic pigmented ocular tumor model.
Neoplasms
Effects of gamma irradiation on the biological activity of green tea byproduct extracts and a comparison with green tea leaf extracts
Neoplasms
Effects of various synthetic retinoids on proliferation and immunophenotype of human melanoma cells in vitro.
Neoplasms
Efficient transduction and long-term retroviral expression of the melanoma-associated tumor antigen tyrosinase in CD34(+) cord blood-derived dendritic cells.
Neoplasms
Electrochemical, photoelectrochemical, and piezoelectric analysis of tyrosinase activity by functionalized nanoparticles.
Neoplasms
Enhanced Drug Photosafety by Interchromophoric Interaction Due to Intramolecular Charge Separation.
Neoplasms
Evaluation of eight melanocytic and neural crest-associated markers in a well-characterised series of 124 malignant peripheral nerve sheath tumours (MPNST): useful to distinguish MPNST from melanoma?
Neoplasms
Evaluation of tyrosinase mRNA as a tumor marker in the blood of melanoma patients.
Neoplasms
Evaluation of variants of melanoma-associated antigen genes and mRNA transcripts in melanomas of dogs.
Neoplasms
Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors: Quercetin and the Central Role of p53.
Neoplasms
Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma.
Neoplasms
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Neoplasms
Expression of immunohistochemical markers in primary and metastatic malignant melanoma: a comparative study in 70 patients using a tissue microarray technique.
Neoplasms
Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Ralpha2, gp100 and TRP-2 for immunotherapy.
Neoplasms
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Neoplasms
Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery.
Neoplasms
Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells.
Neoplasms
Flow cytometry assessment of residual melanoma cells in tumor-infiltrating lymphocyte cultures.
Neoplasms
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Neoplasms
Giant congenital nodular melanoma in a newborn: a case report and literature review.
Neoplasms
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Neoplasms
Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.
Neoplasms
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Neoplasms
High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.
Neoplasms
High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma.
Neoplasms
HLA-A(*)0201(+) Plasmacytoid Dendritic Cells Provide a Cell-Based Immunotherapy for Melanoma Patients.
Neoplasms
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
Neoplasms
Human Heat Shock Protein 70 Enhances Tumor Antigen Presentation through Complex Formation and Intracellular Antigen Delivery without Innate Immune Signaling.
Neoplasms
Human melanogenesis; the tyrosinase reaction in pigment cell neoplasms, with particular reference to the malignant melanoma; preliminary report.
Neoplasms
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Neoplasms
Humoral immune responses of cancer patients against "Cancer-Testis" antigen NY-ESO-1: correlation with clinical events.
Neoplasms
Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.
Neoplasms
Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment.
Neoplasms
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression.
Neoplasms
Imaging of Gastrointestinal Stromal Tumors: From Diagnosis to Evaluation of Therapeutic Response.
Neoplasms
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model.
Neoplasms
Immune responses to the HLA-A*0201-restricted epitopes of tyrosinase and glycoprotein 100 enable control of melanoma outgrowth in HLA-A*0201-transgenic mice.
Neoplasms
Immunohistochemical analysis of BRAF(V600E) expression of primary and metastatic melanoma and comparison with mutation status and melanocyte differentiation antigens of metastatic lesions.
Neoplasms
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
Neoplasms
Immunohistochemical Identification of Canine Melanocytic Neoplasms With Antibodies to Melanocytic Antigen PNL2 and Tyrosinase: Comparison With Melan A.
Neoplasms
Immunologic hierarchy, class II MHC promiscuity, and epitope spreading of a melanoma helper peptide vaccine.
Neoplasms
Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.
Neoplasms
Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma.
Neoplasms
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
Neoplasms
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Neoplasms
Individualized synthetic peptide vaccines with GM-CSF in locally advanced melanoma patients.
Neoplasms
Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.
Neoplasms
Interlaboratory evaluation of a new reverse transcriptase polymerase chain reaction-based enzyme-linked immunosorbent assay for the detection of circulating melanoma cells: a multicenter study of the Dermatologic Cooperative Oncology Group.
Neoplasms
Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma.
Neoplasms
Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses.
Neoplasms
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.
Neoplasms
Malignant melanoma with a rhabdoid phenotype: histologic, immunohistochemical, and ultrastructural study of a case and review of the literature.
Neoplasms
Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid.
Neoplasms
Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma".
Neoplasms
Malignant rhabdoid tumors originating within and outside the central nervous system are clinically and molecularly heterogeneous.
Neoplasms
MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases.
Neoplasms
Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.
Neoplasms
Melanogenesis in genetically determined pigment cell tumors of platyfish and platyfish-swordtail hybrids: correlation between tyrosine activity and degree of malignancy.
Neoplasms
Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells.
Neoplasms
Melanotic Xp11 Translocation Renal Cancer: A Case With PSF-TFE3 Gene Fusion and Up-regulation of Melanogenetic Transcripts.
Neoplasms
Melanotrichoblastoma: immunohistochemical study of a variant of pigmented trichoblastoma.
Neoplasms
Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab.
Neoplasms
Micropthalmia transcription factor (MITF) as a diagnostic marker for metastatic melanomas negative for other melanoma markers.
Neoplasms
Molecular and prognostic classification of advanced melanoma: a multi-marker microcontamination assay of peripheral blood stem cells.
Neoplasms
Molecular detection of circulating tyrosinase mRNA: optimization in a preclinical xenograft mouse melanoma model and further evaluation in samples from advanced melanoma patients.
Neoplasms
Molecular staging in stage II and III melanoma patients and its effect on long-term survival.
Neoplasms
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells.
Neoplasms
Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.
Neoplasms
Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results.
Neoplasms
Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results.
Neoplasms
MR molecular imaging of tumors based on an optimal hTERT promoter tyrosinase expression system.
Neoplasms
Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors.
Neoplasms
MUM-1 Expression Differentiates Tumors in the PEComa Family From Clear Cell Sarcoma and Melanoma.
Neoplasms
Murine tyrosinase expressed by a T7 vector in bone marrow-derived dendritic progenitors effectively prevents and eradicates melanoma tumors in mice.
Neoplasms
Near-Infrared Fluorescent Probe with New Recognition Moiety for Specific Detection of Tyrosinase Activity: Design, Synthesis, and Application in Living Cells and Zebrafish.
Neoplasms
New Methodological Approach for the Rapid and Sensitive Detection of Melanocytes and Melanocytic Tumours. The DOPA-GA Method.
Neoplasms
New nitrosoureas and their spin-labeled derivatives influence dopa-oxidase activity of tyrosinase.
Neoplasms
No correlation of tyrosinase mRNA in bone marrow with prognosis of metastatic melanoma.
Neoplasms
Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.
Neoplasms
Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis.
Neoplasms
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
Neoplasms
Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients.
Neoplasms
Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.
Neoplasms
Oxidative conjugation of chlorogenic acid with glutathione. Structural characterization of addition products and a new nitrite-Promoted pathway.
Neoplasms
Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.
Neoplasms
Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma.
Neoplasms
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Neoplasms
Phase I evaluation of interleukin-2-transfected irradiated allogeneic melanoma for the treatment of metastatic melanoma: appendix 1: protocol.
Neoplasms
Phase I trial of intravenous peptide-pulsed dendritic cells in patients with metastatic melanoma.
Neoplasms
Phenoloxidase activity of intact and chemically modified functional unit RvH1: a from molluscan Rapana venosa hemocyanin.
Neoplasms
Phosphonic and phosphinic acid analogues of tyrosine and 3,4-dihydroxyphenylalanine (dopa) as potential antimelanotic agents.
Neoplasms
Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients.
Neoplasms
Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.
Neoplasms
Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.
Neoplasms
Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy.
Neoplasms
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Neoplasms
Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of in vitro amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma.
Neoplasms
Primary Cutaneous Nevoid Melanoma With Homer-Wright Rosettes: A Hitherto Unrecognized Variant with Immunohistochemical and Ultrastructural Study.
Neoplasms
Primary malignant melanoma of the oesophagus: a clinical and pathological study with emphasis on the immunophenotype of the tumours for melanocyte differentiation markers and cancer/testis antigens.
Neoplasms
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Neoplasms
Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time.
Neoplasms
Prognostic value of microphthalmia-associated transcription factor and tyrosinase as markers for circulating tumor cells detection in patients with melanoma.
Neoplasms
Prognostic value of RT-PCR tyrosinase detection in peripheral blood of melanoma patients.
Neoplasms
Prognostic value of tyrosinase reverse-transcriptase polymerase chain reaction in metastatic melanoma.
Neoplasms
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.
Neoplasms
Purification of tyrosinase to homogeneity based on its resistance to sodium dodecyl sulfate-proteinase K digestion.
Neoplasms
Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease.
Neoplasms
Reactivity to tyrosinase: expression in cancer (melanoma) and autoimmunity (vitiligo).
Neoplasms
Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.
Neoplasms
Relationship between sentinel lymph node status and regression of primary malignant melanoma.
Neoplasms
Responsive Mn(II) complexes for potential applications in diagnostic Magnetic Resonance Imaging.
Neoplasms
Reverse transcriptase-polymerase chain reaction detection of circulating tumor cells in patients with melanoma: correlation with clinical stage, tumor thickness and histological type.
Neoplasms
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
Neoplasms
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor.
Neoplasms
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Neoplasms
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
Neoplasms
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.
Neoplasms
Serum protein s-100 predicts clinical outcome in patients with melanoma treated with adjuvant interferon--comparison with tyrosinase rt-PCR.
Neoplasms
Simultaneous analysis of tyrosinase mRNA and markers of tyrosinase activity in the blood of patients with metastatic melanoma.
Neoplasms
Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes.
Neoplasms
STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
Neoplasms
Stem cell marker nestin expression in peripheral blood of patients with melanoma.
Neoplasms
Suppression of C8161 melanoma metastatic ability by chromosome 6 induces differentiation-associated tyrosinase and decreases proliferation on adhesion-restrictive substrates mediated by overexpression of p21WAF1 and down-regulation of bcl-2 and cyclin D3.
Neoplasms
Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis.
Neoplasms
Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.
Neoplasms
T cell immune function in tumor, skin and peripheral blood of advanced stage melanoma patients: implications for immunotherapy.
Neoplasms
T cell responses in early-stage melanoma patients occur frequently and are not associated with humoral response.
Neoplasms
T-Cell Mediated Immune Responses Induced in ret Transgenic Mouse Model of Malignant Melanoma.
Neoplasms
T-cell responses against tyrosinase 368-376(370D) peptide in HLA*A0201+ melanoma patients: randomized trial comparing incomplete Freund's adjuvant, granulocyte macrophage colony-stimulating factor, and QS-21 as immunological adjuvants.
Neoplasms
Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences.
Neoplasms
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
Neoplasms
The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction.
Neoplasms
The effects of pro-opiomelanocortin peptides on cyclic AMP and tyrosinase in melanoma cells.
Neoplasms
The majority of autologous cytolytic T-lymphocyte clones derived from peripheral blood lymphocytes of a melanoma patient recognize an antigenic peptide derived from gene Pmel17/gp100.
Neoplasms
The regulation of cyclic AMP production and the role of cyclic AMP in B16 melanoma cells of differing metastatic potential.
Neoplasms
The role of the immune system in anti-tumour responses. Potential for drug therapy.
Neoplasms
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Neoplasms
Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes.
Neoplasms
Transgenic mice with pigmented intraocular tumors: tissue of origin and treatment.
Neoplasms
Transglutaminase-dependent antiproliferative and differentiative properties of nimesulide on B16-F10 mouse melanoma cells.
Neoplasms
Transient expression of high molecular weight, heat sensitive, trypsin-resistant form of tyrosinase in B-16 melanoma cells.
Neoplasms
Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management.
Neoplasms
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines.
Neoplasms
Tyrosinase activity and isoenzyme distribution corresponding to growth and regression of melanoma in Sinclair miniature swine.
Neoplasms
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Neoplasms
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Neoplasms
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients.
Neoplasms
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Neoplasms
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Neoplasms
Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT-TYR).
Neoplasms
Tyrosinase immunoreactivity in fine-needle aspiration samples of metastatic malignant melanoma.
Neoplasms
Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.
Neoplasms
Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy.
Neoplasms
Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression.
Neoplasms
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: a preliminary report.
Neoplasms
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
Neoplasms
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Neoplasms
Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.
Neoplasms
Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.
Neoplasms
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Neoplasms
Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening.
Neoplasms
Xanthogranulomas with inconspicuous foam cells and giant cells mimicking malignant melanoma: a clinical, histologic, and immunohistochemical study of three cases.
Neoplasms
Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes.
Neoplasms
[A case of amelanotic anorectal malignant melanoma mimicking gastrointestinal stromal tumor].
Neoplasms
[Clinical manifestations, therapeutic response to tyrosinase inhibitor and RET gene activating mutation in a patient with multiple endocrine neoplasia 2B].
Neoplasms
[Immunohistochemical demonstration of tyrosinase 4 in normal skin and melanocytic tumors]
Neoplasms
[Investigation of tyrosinase activity and phospholipid composition in Harding-Passey melanoma microsomal fraction]
Neoplasms
[Melanoma and cancer emergence in persons of 20-60 years against normal quantity of cambial cells in morphofunctional zones].
Neoplasms
[Tumor antigens presented to T helper lymphocytes--critical components of the cancer vaccine]
Neoplastic Cells, Circulating
A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.
Neoplastic Cells, Circulating
A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.
Neoplastic Cells, Circulating
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
Neoplastic Cells, Circulating
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Neoplastic Cells, Circulating
Detection of circulating melanoma cells by specific amplification of tyrosinase complementary DNA is not a reliable tumor marker in melanoma patients: a clinical two-center study.
Neoplastic Cells, Circulating
Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma.
Neoplastic Cells, Circulating
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Neoplastic Cells, Circulating
Interlaboratory evaluation of a new reverse transcriptase polymerase chain reaction-based enzyme-linked immunosorbent assay for the detection of circulating melanoma cells: a multicenter study of the Dermatologic Cooperative Oncology Group.
Neoplastic Cells, Circulating
Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.
Neoplastic Cells, Circulating
Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma.
Neoplastic Cells, Circulating
Prognostic value of microphthalmia-associated transcription factor and tyrosinase as markers for circulating tumor cells detection in patients with melanoma.
Neoplastic Cells, Circulating
Prognostic value of multiple reverse transcription-PCR tyrosinase testing for circulating neoplastic cells in malignant melanoma.
Neoplastic Cells, Circulating
Prognostic value of tyrosinase reverse-transcriptase polymerase chain reaction in metastatic melanoma.
Neoplastic Cells, Circulating
Relationship between sentinel lymph node status and regression of primary malignant melanoma.
Neoplastic Cells, Circulating
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
Neoplastic Cells, Circulating
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients.
Neoplastic Cells, Circulating
Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression.
Neoplastic Cells, Circulating
[Detection of tumor circulating cells in patients with ocular melanoma]
Nerve Sheath Neoplasms
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Nervous System Diseases
Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems.
Neurilemmoma
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
Neurilemmoma
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Neurilemmoma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Neuroblastoma
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
Neuroblastoma
Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach.
Neuroblastoma
Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.
Neuroblastoma
Comparison of in vitro cytotoxicity of N-acetyl and N-propionyl derivatives of phenolic thioether amines in melanoma and neuroblastoma cells and the relationship to tyrosinase and tyrosine hydroxylase enzyme activity.
Neuroblastoma
Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.
Neuroblastoma
Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase.
Neuroblastoma
Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity.
Neuroblastoma
Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.
Neuroblastoma
Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.
Neuroblastoma
Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.
Neurodegenerative Diseases
Chemical Characterisation-Biological Evaluation of Greek Cultivar Cardoon Seeds (Cynara cardunculus). A By-product with Potential High Added Value.
Neurodegenerative Diseases
Cholinesterase and Tyrosinase Inhibitory Potential and Antioxidant Capacity of Lysimachia verticillaris L. and Isolation of the Major Compounds.
Neurodegenerative Diseases
Development of an Efficient Protocol for Cimifugin Isolation from Peucedanum schottii and Evaluation of Enzyme Inhibitory Activity.
Neurodegenerative Diseases
Evaluation of crocin and curcumin affinity on mushroom tyrosinase using surface plasmon resonance.
Neurodegenerative Diseases
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors.
Neurodegenerative Diseases
Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions.
Neurodegenerative Diseases
New evidence for presence of tyrosinase in substantia nigra, forebrain and midbrain.
Neurodegenerative Diseases
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Neurodegenerative Diseases
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.
Neurodegenerative Diseases
Synthesis of new 1,2,4-triazole-(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis.
Neurofibroma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Neurofibromatoses
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Neurofibrosarcoma
Evaluation of eight melanocytic and neural crest-associated markers in a well-characterised series of 124 malignant peripheral nerve sheath tumours (MPNST): useful to distinguish MPNST from melanoma?
Neurofibrosarcoma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Neuroinflammatory Diseases
Trichilia catigua and Turnera diffusa extracts: In vitro inhibition of tyrosinase, antiglycation activity and effects on enzymes and pathways engaged in the neuroinflammatory process.
Nevus
A histochemical autoradiographic method for demonstration of tyrosinase in human melanocytes, nevi and malignant melanoma.
Nevus
BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM.
Nevus
Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis.
Nevus
Expression of melanocyte differentiation antigens and ki-67 in nodal nevi and comparison of ki-67 expression with metastatic melanoma.
Nevus
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Nevus
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Nevus
The effects of gp100 and tyrosinase peptide vaccinations on nevi in melanoma patients.
Nevus
The Presence of Alpha-Synuclein in Skin from Melanoma and Patients with Parkinson's Disease.
Nevus
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Nevus
Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.
Nevus
[Immunologic analysis of tyrosinase in malignant melanoma, nevi and clinically normal skin]
Nevus
[The sentinel lymph node in melanoma: utilization of molecular biology (RT-PCR) to detect occult metastases]
Nevus, Intradermal
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Nevus, Pigmented
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
Nevus, Pigmented
Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.
Nevus, Pigmented
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Nystagmus, Congenital
Incremental light detection thresholds across the central visual field of human albinos.
Obesity
Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
Obesity
Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's.
Osteoporosis
'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions.
Ovarian Neoplasms
Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma.
Ovarian Neoplasms
Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil.
Ovarian Neoplasms
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells.
Pain Insensitivity, Congenital
[Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications: case report].
Papilloma
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity.
Paralysis
Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems.
Parkinson Disease
3D QSAR pharmacophore-based virtual screening for the identification of potential inhibitors of tyrosinase.
Parkinson Disease
Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)
Parkinson Disease
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Parkinson Disease
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Parkinson Disease
Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.
Parkinson Disease
Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity.
Parkinson Disease
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Parkinson Disease
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.
Parkinson Disease
In silico approach to inhibition of tyrosinase by ascorbic acid using molecular docking simulations.
Parkinson Disease
Kinetic and sensitive analysis of tyrosinase activity using electron transfer complexes: in vitro and intracellular study.
Parkinson Disease
Laccase- and peroxidase-free tyrosinase production by isolated microbial strain.
Parkinson Disease
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
Parkinson Disease
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts.
Parkinson Disease
New evidence for presence of tyrosinase in substantia nigra, forebrain and midbrain.
Parkinson Disease
Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease.
Parkinson Disease
Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system.
Parkinson Disease
Synthesis and bioassay of a new class of furanyl-1,3,4-oxadiazole derivatives.
Parkinson Disease
Synthesis and crystal structures of the potential tyrosinase inhibitors N-(4-acetylphenyl)-2-chloroacetamide and 2-(4-acetylanilino)-2-oxoethyl cinnamate.
Parkinson Disease
Synthesis of new 1,2,4-triazole-(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis.
Parkinson Disease
The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.
Parkinson Disease
Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.
Parkinson Disease
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.
Periodontitis
[A method for demonstrating leukocyte enzyme activity in the oral cavity in relation to the periodontal findings. A preliminary report]
Peripheral Nervous System Neoplasms
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Phenylketonurias
Competitive inhibition of mammalian tyrosinase by phenylalanine and its relationship to hair pigmentation in phenylketonuria.
Photosensitivity Disorders
Photoinactivation of tyrosinase sensitized by folic acid photoproducts.
Piebaldism
Functional regulation of tyrosinase and LAMP gene family of melanogenesis and cell death in immortal murine melanocytes after repeated exposure to ultraviolet B.
Pigmentation Disorders
(Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene)thiazol-4(5H)-one Derivatives as Novel Tyrosinase Inhibitors.
Pigmentation Disorders
A Series of Benzylidenes Linked to Hydrazine-1-carbothioamide as Tyrosinase Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationship.
Pigmentation Disorders
Antioxidant, Antimicrobial, and Bioactive Potential of Two New Haloarchaeal Strains Isolated from Odiel Salterns (Southwest Spain).
Pigmentation Disorders
Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.
Pigmentation Disorders
Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908).
Pigmentation Disorders
Inhibitory activity and mechanism of trilobatin on tyrosinase: kinetics, interaction mechanism and molecular docking.
Pigmentation Disorders
Mushroom Tyrosinase-Based Enzyme Inhibition Assays Are Not Suitable for Bioactivity-Guided Fractionation of Extracts.
Pigmentation Disorders
Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control.
Pigmentation Disorders
Nanoliposomes encapsulation of enriched phenolic fraction from pistachio hulls and its antioxidant, anti-inflammatory, and anti-melanogenic activities.
Pigmentation Disorders
Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism.
Pigmentation Disorders
Recombinant Tyrosinase from Polyporus arcularius: Overproduction in Escherichia coli, Characterization, and Use in a Study of Aurones as Tyrosinase Effectors.
Pigmentation Disorders
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Pigmentation Disorders
SAR and QSAR research on tyrosinase inhibitors using machine learning methods.
Pigmentation Disorders
Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile.
Pigmentation Disorders
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action.
Pigmentation Disorders
Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in ?-MSH-stimulated B16F10 melanoma cells.
Pigmentation Disorders
Vasoactive intestinal peptide stimulates melanogenesis in B16F10 mouse melanoma cells via CREB/MITF/tyrosinase signaling.
Pigmentation Disorders
[Inhibitory effects of Rhodiola plants and their oligomeric proanthocyanidins on tyrosinase and Abeta42 aggregation].
Pleural Effusion
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: a preliminary report.
Pleural Effusion
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
Polydactyly
A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment.
Prader-Willi Syndrome
Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism.
Prader-Willi Syndrome
Oculocutaneous albinoidism as a manifestation of reduced neural crest derivatives in the Prader-Willi syndrome.
Prostatic Neoplasms
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Prostatic Neoplasms
Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes.
Prostatic Neoplasms
Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers.
Protoporphyria, Erythropoietic
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Psoriasis
Gene Expression Analysis of the Corticotrophin-releasing Hormone-proopiomelanocortin System in Psoriasis Skin Biopsies.
Pulmonary Fibrosis
[Preliminary study of exon sequence in pneumoconiosis using high-throughput and intervention of EGFR-TKIs on silicosis rats].
Renal Insufficiency, Chronic
Novel Bacillus subtilis Spore-Displayed Tyrosinase Kit for Rapid Detection of Tyrosine in Urine: Pharmaceutical Applications for the Early Diagnosis of Kidney-Related Diseases.
Retinal Degeneration
FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis.
Retinoblastoma
Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma.
Sarcoma
Expression and network analysis of genes related to melanocyte development in the Silky Fowl and White Leghorn embryos.
Sarcoma
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Sarcoma
MicroRNA-5110 regulates pigmentation by cotargeting melanophilin and WNT family member 1.
Sarcoma
Technical note: Advantages and limitations of authenticating Palmera goat dairy products by pyrosequencing the melanocortin 1 receptor (MC1R) gene.
Sarcoma
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Sarcoma
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Sarcoma, Avian
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines.
Sarcoma, Clear Cell
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Sarcoma, Kaposi
Detection of tyrosinase mRNA in tumor tissue microdissections from classic Kaposi's sarcoma.
Scabies
TYROSINASE INHERITANCE IN STREPTOMYCES SCABIES. II. INDUCTION OF TYROSINASE DEFICIENCY BY ACRIDINE DYES.
Skin Diseases
Activities of different types of Thai honey on pathogenic bacteria causing skin diseases, tyrosinase enzyme and generating free radicals.
Skin Diseases
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Skin Diseases
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Skin Diseases
In Situ Fluorogenic and Chromogenic Reactions for the Sensitive Dual-Readout Assay of Tyrosinase Activity.
Skin Diseases
Inhibitory mechanism of epicatechin gallate on tyrosinase: inhibitory interaction, conformational change and computational simulation.
Skin Diseases
Polymethyldopa Nanoparticles-Based Fluorescent Sensor for Detection of Tyrosinase Activity.
Skin Diseases
Specific Imaging of Tyrosinase in Vivo with 3-Hydroxybenzyl Caged D-Luciferins.
Skin Diseases
The inhibition effect of starch nanoparticles on tyrosinase activity and its mechanism.
Skin Diseases
Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.
Skin Diseases
Tyrosinase Inhibitory and Anti-oxidative Effects of Lactic Acid Bacteria Isolated from Dairy Cow Feces.
Skin Neoplasms
A Series of Benzylidenes Linked to Hydrazine-1-carbothioamide as Tyrosinase Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationship.
Skin Neoplasms
Analysis of Kojic Acid Derivatives as Competitive Inhibitors of Tyrosinase: A Molecular Modeling Approach.
Skin Neoplasms
Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects.
Skin Neoplasms
Effective Inhibition of Skin Cancer, Tyrosinase and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from Green Alga Haematococcus pluvialis.
Skin Neoplasms
Protective effect of Daucus carota against UV-DMBA induced skin cancer in mice.
Skin Neoplasms
Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cells.
Starvation
Mitogen-activated protein kinase cascade required for regulation of development and secondary metabolism in Neurospora crassa.
Starvation
Role of sulfhydryl compounds in the control of tyrosinase activity in Neurospora crassa.
Sunburn
Protective effects of an extract of the freshwater microalga Scenedesmus rubescens on UV-irradiated skin cells.
Tetanus
Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells.
Tetanus
Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma.
Thrombophlebitis
Supravenous hyperpigmentation, transverse leuconychia and transverse melanonychia after chemotherapy for Hodgkin's disease.
Tics
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Tourette Syndrome
The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase.
Tuberculosis, Multidrug-Resistant
Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase.
tyrosinase deficiency
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
tyrosinase deficiency
Genetic and experimental studies on a new pigment mutant in Xenopus laevis.
tyrosinase deficiency
Novel human pathological mutations. Gene symbol: TYR. Disease: tyrosinase deficiency.
tyrosinase deficiency
Tyrosinase deficiency increases protein carbonyl content in substantia nigra of mice administered retinol palmitate.
tyrosinase deficiency
TYROSINASE INHERITANCE IN STREPTOMYCES SCABIES. II. INDUCTION OF TYROSINASE DEFICIENCY BY ACRIDINE DYES.
Tyrosinemias
The Inhibitory Activity of Plants from Central Argentina on p-Hydroxyphenylpyruvate Dioxygenase. Isolation and Mechanism of Inhibition of a Flavanone from Flourensia oolepis.
Urticaria
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Usher Syndromes
Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I.
Uveomeningoencephalitic Syndrome
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease.
Uveomeningoencephalitic Syndrome
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient.
Uveomeningoencephalitic Syndrome
Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease.
Uveomeningoencephalitic Syndrome
Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.
Vaccinia
A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).
Vaccinia
Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanoma.
Vaccinia
Clinical protocol. Immunization of patients with malignant melanoma with autologous CD34(+) cell-derived dendritic cells transduced ex vivo with a recombinant replication-deficient vaccinia vector encoding the human tyrosinase gene: a phase I trial.
Vaccinia
Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma.
Vaccinia
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Vaccinia
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.
Vaccinia
Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma-associated antigen: induction of tyrosinase- and melanoma-specific human leukocyte antigen A*0201-restricted cytotoxic T cells in vitro and in vivo.
Vaccinia
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
Vaccinia
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
Vaccinia
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.
Vesicular Stomatitis
Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma.
Virus Diseases
Tissue-specific expression of mouse tyrosinase gene in cultured chicken cells.
Virus Diseases
Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK-1) is influenced by temperature, but not by virus infection or bacterin stimulation.
Vision, Low
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Vision, Low
Prenatal diagnosis of oculocutaneous albinism type I: review and personal experience.
Vitiligo
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Vitiligo
Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice.
Vitiligo
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Vitiligo
Comparison of tyrosinase antibody, tyrosinase-related protein-1 and -2 antibodies, melanin-concentrating hormone receptor antibody levels with autologous serum skin test and autologous plasma skin test results in patients with vitiligo.
Vitiligo
Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients.
Vitiligo
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Vitiligo
Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo.
Vitiligo
Definition of anti-tyrosinase MAb T311 linear determinant by proteome-based similarity analysis.
Vitiligo
Demonstration of tyrosinase in the vitiligo skin of human beings by a sensitive fluorometric method as well as by 14C(U)-L-tyrosine incorporation into melanin.
Vitiligo
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Vitiligo
Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay.
Vitiligo
Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo.
Vitiligo
Effects of 4-tertiary butylphenol on the tyrosinase activity in human melanocytes.
Vitiligo
Enhancement of gene expression and melanin production of human tyrosinase gene loaded in elastic cationic niosomes.
Vitiligo
Enhancement of transdermal absorption, gene expression and stability of tyrosinase plasmid (pMEL34)-loaded elastic cationic niosomes: Potential application in vitiligo treatment.
Vitiligo
Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study.
Vitiligo
Factors affecting vitiligo response to treatment: do MiRNA 196a2C/T gene polymorphism and serum tyrosinase levels have any role?
Vitiligo
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi.
Vitiligo
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Vitiligo
Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis.
Vitiligo
Identification of epitopes on tyrosinase which are recognized by autoantibodies from patients with vitiligo.
Vitiligo
Identification of Novel HLA-A*0201-Restricted CTL Epitopes in Chinese Vitiligo Patients.
Vitiligo
Identification of the Role of Wnt/?-Catenin Pathway Through Integrated Analyses and in vivo Experiments in Vitiligo.
Vitiligo
Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
Vitiligo
Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo.
Vitiligo
Immunoprecipitation of melanogenic enzyme autoantigens with vitiligo sera: evidence for cross-reactive autoantibodies to tyrosinase and tyrosinase-related protein-2 (TRP-2).
Vitiligo
Increased expression of Toll-like receptor 7 and 9 in vitiligo melanocytes: a pilot study.
Vitiligo
Interferon-gamma (IFN-?)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouse.
Vitiligo
Involvement of Different Genes Expressions during Immunological and Inflammatory Responses in Vitiligo.
Vitiligo
Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients.
Vitiligo
Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and the downstream effector, MITF-M.
Vitiligo
Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo.
Vitiligo
Melanogenic effect of purified mushroom tyrosinase on B16F10 Melanocytes: A Phase Contrast and Immunofluorescence Microscopic Study.
Vitiligo
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
Vitiligo
miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1.
Vitiligo
Oxidized tyrosinase: A possible antigenic stimulus for non-segmental vitiligo autoantibodies.
Vitiligo
Potent melanin production enhancement of human tyrosinase gene by Tat and an entrapment in elastic cationic niosomes: Potential application in vitiligo gene therapy.
Vitiligo
Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity.
Vitiligo
Ratiometric target-triggered fluorescent silicon nanoparticles probe for quantitative visualization of tyrosinase activity.
Vitiligo
Screening the Marker Components in Psoralea corylifolia L. with the Aids of Spectrum-Effect Relationship and Component Knock-Out by UPLC-MS².
Vitiligo
Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo.
Vitiligo
Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo.
Vitiligo
Targeted gene disruption in the Xenopus tropicalis genome using designed TALE nucleases.
Vitiligo
The antibody response against MART-1 differs in patients with melanoma-associated leucoderma and vitiligo.
Vitiligo
The clinical significance of antityrosinase antibodies in melanoma and related hypopigmentary lesions.
Vitiligo
The role of VIT1/FBXO11 in the regulation of apoptosis and tyrosinase export from endoplasmic reticulum in cultured melanocytes.
Vitiligo
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo.
Vitiligo
Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.
Vitiligo
Vitiliginous achromia with malignant melanoma. Tyrosinase activity and ultrastructural study of achromic and normal skin.
Vitiligo
Vitiligo: analysis of grafting versus curettage alone, using melanocyte morphology and reverse transcriptase polymerase chain reaction for tyrosinase mRNA.
Vitiligo
[Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells].
Vitiligo
[Expression and purification of epitope peptide of human tyrosinase and its antigenicity in vitiligo patients]
Vitiligo
[Expression of InnVit/FBXO11 in vitiligo and its role in tyrosinase export from endoplasmic reticulum]
Vitreoretinopathy, Proliferative
Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy.
Waardenburg Syndrome
alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome.
Wilms Tumor
Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma.
Xanthogranuloma, Juvenile
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetics
-
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.03
3-hydroxyphlorizin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.045
chrysin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.0008
phloretin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity. Phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.087
phloridzin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.0025
pinosylvin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.042
protocatechuic acid
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.08
rutin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity
0.0006
3-hydroxyphloretin
Homo sapiens
-
potent hydroxyl radical-scavenging, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.032
3-hydroxyphloretin
Homo sapiens
-
cellular tyrosinase-reducing activities, reduction of tyrosinase in HEMn cells
0.0011
catechol
Homo sapiens
-
potent hydroxyl radical-scavenging, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
0.022
catechol
Homo sapiens
-
cellular tyrosinase-reducing activities, reduction of tyrosinase in HEMn cells
0.0012
quercetin
Homo sapiens
-
the effect of the formosan apple constituents on hydroxyl radical-scavenging activity, phloretin, quercetin, 3-hydroxyphloretin, catechol, and pinosylvin have the strongest hydroxyl radical-scavenging properties
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
350.02
purified recombinant wild-type intra-melanosomal domain, pH 7.4, 37°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.4
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 8.5
-
less than 50% activity below pH 6.5 and above pH 8.5, L-dopa oxidation, recombinant enzyme
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
37
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
prepared from the TXM13 melanotic cells as well as from cells that had undergone gene transfection
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
The immunocytochemistry shows that the ectopic tyrosinase is located in the cytoplasm, it is propably the membrane-bounded form since no detection of enzyme activity with the soluble solution without Triton X-100 is possible, nor is it found in Western blotting
brenda
additional information
membrane associated enzyme, deletion of the anchoring helix does not affect the tyrosinase activity
brenda
additional information
the enzyme sequence contains a melanosome-directing signal sequence
-
brenda
additional information
-
the enzyme sequence contains a melanosome-directing signal sequence
-
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
malfunction
physiological function
additional information
malfunction
mutations in the tyrosinase gene cause oculocutaneous albinism type 1 (OCA1), an autosomal recessive disease associated with reduced melanin pigment in the hair, skin, and eyes and decreased quality of vision
malfunction
oculocutaneous albinism Type 1 (OCA1) is an autosomal recessive disorder caused by mutations in the tyrosinase gene. Two subtypes of OCA1 exxist, severe OCA1A with complete absence of tyrosinase activity and less severe OCA1B with residual tyrosinase activity. The recombinant OCA1A mutants expressed in insect cells show very low protein expression, protein yield, and are enzymatically inactive, while mutants mimicking OCA1B are biochemically similar to the wild-type, but exhibit lower specific activities and protein stabilities than the wild-type enzyme. OCA1A mutations inactivate tyrosinase and result in severe phenotype, while OCA1B mutations partially inactive tyrosinase and results in OCA1B albinism
metabolism
tyrosinase catalyzes the first two steps of the melanin synthesis pathway: hydroxylation of L-tyrosine to L-3,4-dihydroxyphenylalanine, L-DOPA, monophenolase or cresolase activity, EC1.14.18.1, and the subsequent oxidation of L-DOPA to dopaquinone, diphenol oxidase or catecholase activity, EC 1.10.3.1
metabolism
tyrosinase is a key enzyme in melanogenesis. The catalysis of L-tyrosine to L-dopa is the rate-limiting step of the enzymatic pathway in melanin formation
physiological function
human tyrosinase is the first enzyme of the multistep process of melanogenesis. It catalyzes the hydroxylation of L-tyrosine to L-dihydroxyphenylalanine and the following oxidation of o-diphenol to the corresponding quinone, L-dopaquinone
physiological function
the enzyme catalyzes the oxidation of L-tyrosine (monophenol substrate) and L-3,4-dihydroxyphenylalanine (L-DOPA, diphenol substrate) to form dopaquinone. The monophenolase and diphenol oxidase activities are linked to the tyrosinase active site, which is composed of six histidine residues that coordinate two copper ions (CuA and CuB) essential for activity
physiological function
tyrosinase is a key enzyme in melanogenesis, which is essential for pigmentation. The catalysis of L-tyrosine to L-dopa is the rate-limiting step of the enzymatic pathway in melanin formation. Tyrosinase is also an important factor in wound healing and cuticle formation in arthropods and browning in plants
malfunction
-
the reduction of tyrosinase activity associated with the knockdown of membrane-associated transporter protein, MATP, using siRNA is readily recovered by copper treatment in the in vitro L-DOPA oxidase activity assay of tyrosinase. N-glycosylation is an important factor for tyrosinase activity, which was reduced in the MATP-knockdown cells
physiological function
-
tyrosinases are essential enzymes in melanin biosynthesis and therefore responsible for pigmentation of skin and hair
physiological function
-
membrane-associated transporter protein, MATP, may play an important role in regulating tyrosinase activity via controlling melanosomal pH
additional information
homology model of human tyrosinase incorporated into the phospholipid membrane, overview
additional information
-
homology model of human tyrosinase incorporated into the phospholipid membrane, overview
additional information
homology modeling of the enzyme sructure using the crystal structure of bacterial tyrosinase from Bacillus megaterium as template, PDB ID 3NQ1
additional information
-
homology modeling of the enzyme sructure using the crystal structure of bacterial tyrosinase from Bacillus megaterium as template, PDB ID 3NQ1
additional information
structure homology modeling of wild-type an dmutant enzymes
additional information
-
structure homology modeling of wild-type an dmutant enzymes
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). TYRO_HUMAN
529
1
60393
Swiss-Prot
Secretory Pathway (Reliability: 1)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
66700
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
glycoprotein
glycoprotein
glycosylation sites N86, N111, N337 and N371 are required for recognition by individual T cell clones
glycoprotein
tyrosinase is a membrane-associated glycoprotein. The purified recombinant human tyrosinase is a soluble monomeric glycoprotein. N-Glycosylation of tyrosinase appears critical for enzyme stability and enzymatic function
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
N111Q
glycosylation site is required for recognition by individual T cell clones
N337Q
glycosylation site is required for recognition by individual T cell clones
N371Q
glycosylation site is required for recognition by individual T cell clones
N86Q
glycosylation site is required for recognition by individual T cell clones
N111Q
-
mutation in potential N-glycosylation site, 95% of wild-type L-dopa oxidase activity
N111Q/N337Q
-
mutations in potential N-glycosylation site, 95% of wild-type L-dopa oxidase activity
N111Q/N337Q/N371Q
-
mutations in potential N-glycosylation site, no L-dopa oxidase activity
N111Q/N371Q
-
mutations in potential N-glycosylation site, 59% of wild-type L-dopa oxidase activity
N337Q
-
mutation in potential N-glycosylation site, 93% of wild-type L-dopa oxidase activity
N337Q/N3711Q
-
mutations in potential N-glycosylation site, 37% of wild-type L-dopa oxidase activity
N371Q
-
mutation in potential N-glycosylation site, 64% of wild-type L-dopa oxidase activity
N86Q
-
mutation in potential N-glycosylation site, 70% of wild-type L-dopa oxidase activity
N86Q/N111Q
-
mutations in potential N-glycosylation site, 68% of wild-type L-dopa oxidase activity
N86Q/N111Q/N337Q
-
mutations in potential N-glycosylation site, no L-dopa oxidase activity
N86Q/N111Q/N337Q/N371Q
-
mutations in potential N-glycosylation site, no L-dopa oxidase activity
N86Q/N111Q/N371Q
-
mutations in potential N-glycosylation site, no L-dopa oxidase activity
N86Q/N337Q
-
mutations in potential N-glycosylation site, 35% of wild-type L-dopa oxidase activity
N86Q/N337Q/N371Q
-
mutations in potential N-glycosylation site, no L-dopa oxidase activity
N86Q/N371Q
-
mutations in potential N-glycosylation site, 30% of wild-type L-dopa oxidase activity, contains at least 3 times less copper than wild-type
additional information
additional information
generation of the recombinant human tyrosinase intra-melanosomal domain and mutant variants, which mimic genetic changes in both subtypes of OCA1 patients, by site-directed mutagenesis and recombinant expression in insect cells. The recombinant OCA1A show very low protein expression, protein yield, and are enzymatically inactive, while mutants mimicking OCA1B are biochemically similar to the wild-type, but exhibit lower specific activities and protein stabilities than the wild-type enzyme
additional information
-
generation of the recombinant human tyrosinase intra-melanosomal domain and mutant variants, which mimic genetic changes in both subtypes of OCA1 patients, by site-directed mutagenesis and recombinant expression in insect cells. The recombinant OCA1A show very low protein expression, protein yield, and are enzymatically inactive, while mutants mimicking OCA1B are biochemically similar to the wild-type, but exhibit lower specific activities and protein stabilities than the wild-type enzyme
additional information
the strategy of deleting the membrane-anchoring helix is standard to simplify handling of protein. Deletion of the anchoring helix of the human tyrosinase does not affect the tyrosinase activity
additional information
-
the strategy of deleting the membrane-anchoring helix is standard to simplify handling of protein. Deletion of the anchoring helix of the human tyrosinase does not affect the tyrosinase activity
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant His-tagged enzyme from Spdoptera frugiperda Sf9 cells by nickel affinity chromatography and gel filtration
recombinant His-tagged intra-melanosomal domain of wild-type tyrosinase and temperature-sensitive OCA1-related mutant R422Q from whole-insect Trichoplusia ni by nickel affinity chromatography, tag cleavage by TEV protease, dialysis, and two steps of gel filtration, 98.73% purity. The purified recombinant human tyrosinase is a soluble monomeric glycoprotein with an activity that mirrors the tyrosinase in vivo function
recombinant His-tagged intra-melanosomal domain wild-type and mutant variants OCA1A and OCA1B in Trichoplusia ni insect cells by nickel affinity chromatography, ultrafiltration, and gel filtration
ammonium sulfate, DEAE-cellulose, Sephadex G150, trypsin digestion, Sephadex G-150, DEAE-cellulose, partial purification
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene TYR, DNA and amino acid sequence determinatin and analysis, sequence comparisons, recombinant expression of His-tagged intra-melanosomal domain wild-type and mutant variants OCA1A and OCA1B in Trichoplusia ni insect cells using the baculovirus transfection method
recombinant expression of His-tagged intra-melanosomal domain of wild-type tyrosinase and temperature-sensitive OCA1-related mutant R422Q and in whole-insect Trichoplusia ni via transfection with baculovius
the wild-type sequence coding for the enzyme is obtained by restriction digestion of the entire cDNA sequence, subcloning in Escherichia coli H10Bac, and recombinant expression of His-tagged enzyme in Spdoptera frugiperda Sf9 cells via the baculovirus transfection method
expression of wild-type, N86Q, N111Q, N337Q, N371Q and several double and triple mutant enzymes derived from this single mutants in CHO cells
-
tyrosinase gene transfection, by calcium-phosphate precipitation method, into HEK293 cell significantly down-regulates the expression levels of solute carrier family 12, member 4 and 7, which are known to be Cl- transporters. Observation of significant pigmentation of the HEK293 cells
-
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RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
all proteins including hTyrCtr and OCA1B-related mutant variants are a subjected to equilibrium unfolding/refolding using 0.001 mM protein in 10 mM phosphate buffer, pH 7.4, 5 h at 8 M urea, followed by dilution with 10 mM phosphate buffer, pH 7.4 to 0-8 M urea and incubated for 24 h at room temperature
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
pharmacology
-
results indicate that the polyvinylpyrrolidone (PVP)-wrapped fullerene derivative (Radical Sponge) could be expected for its wide-ranged application as a whitening cosmetic material
drug development
-
3-hydroxyphloretin and catechol isolated from the formosan apple, may be useful as cosmetic agents to stimulate skin whitening
drug development
-
acetazolamide is a good candidate for the inhibition of melanin biosynthesis. and might be used as a lead for developing the drugs for treatment of hyperpigmentary disorders and skin whitening
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vijayan, E.; Husain, I.; Ramaiah, A.; Madan, N.C.
Purification of human skin tyrosinase and its protein inhibitor: properties of the enzyme and the mechanism of inhibition by protein
Arch. Biochem. Biophys.
217
738-747
1982
Homo sapiens
brenda
Nishioka, K.
Particulate tyrosinase of human malignant melanoma. Solubilization, purification following trypsin treatment, and characterization
Eur. J. Biochem.
85
137-146
1978
Homo sapiens
brenda
Kwon, B.S.; Haq, A.K.; Pomerantz, S.H.; Halaban, R.
Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus [published erratum appears in Proc Natl Acad Sci U S A 1988 Sep;85(17):6352]
Proc. Natl. Acad. Sci. USA
84
7473-7477
1987
Homo sapiens
brenda
Kong, K.H.; Park, S.Y.; Hong, M.P.; Cho, S.H.
Expression and characterization of human tyrosinase from a bacterial expression system
Comp. Biochem. Physiol. B
125
563-569
2000
Homo sapiens
brenda
Branza-Nichita, N.; Negroiu, G.; Petrescu, A.J.; Garman, E.F.; Platt, F.M.; Wormald, M.R.; Dwek, R.A.; Petrescu, S.M.
Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control
J. Biol. Chem.
275
8169-8175
2000
Homo sapiens
brenda
Housseau, F.; Moorthy, A.; Langer, D.A.; Robbins, P.F.; Gonzales, M.I.; Topalian, S.L.
N-linked carbohydrates in tyrosinase are required for its recognition by human MHC class II-restricted CD4+ T cells
Eur. J. Immunol.
31
2690-2701
2001
Homo sapiens (P14679), Homo sapiens
brenda
Okombi, S.; Rival, D.; Bonnet, S.; Mariotte, A.M.; Perrier, E.; Boumendjel, A.
Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase
Bioorg. Med. Chem. Lett.
16
2252-2255
2006
Homo sapiens
brenda
Kim, Y.J.; Uyama, H.
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
Cell. Mol. Life Sci.
62
1707-1723
2005
Agaricus bisporus, Beta vulgaris, Homo sapiens, Neurospora crassa, Streptomyces glaucescens
brenda
Okombi, S.; Rival, D.; Bonnet,S.; Mariotte,A.M.; Perrier,E.; Boumendjel, A.
Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes
J. Med. Chem.
49
329-333
2006
Homo sapiens
brenda
Xiao, L.; Matsubayashi, K.; Miwa, N.
Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues
Arch. Dermatol. Res.
299
245-257
2007
Homo sapiens
brenda
Han, H.Y.; Lee, J.R.; Xu, W.A.; Hahn, M.J.; Yang, J.M.; Park, Y.D.
Effect of Cl- on tyrosinase: complex inhibition kinetics and biochemical implication
J. Biomol. Struct. Dyn.
25
165-171
2007
Homo sapiens
brenda
Takara, K.; Iwasaki, H.; Ujihara, K.; Wada, K.
Human tyrosinase inhibitor in rum distillate wastewater
J. Oleo Sci.
57
191-196
2008
Homo sapiens
brenda
Lin, Y.P.; Hsu, F.L.; Chen, C.S.; Chern, J.W.; Lee, M.H.
Constituents from the Formosan apple reduce tyrosinase activity in human epidermal melanocytes
Phytochemistry
68
1189-1199
2007
Agaricus bisporus, Homo sapiens
brenda
Yamazaki, Y.; Kawano, Y.; Yamanaka, A.; Maruyama, S.
N-[(dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells
Bioorg. Med. Chem. Lett.
19
4178-4182
2009
Homo sapiens, Mus musculus
brenda
Abu Ubeid, A.; Zhao, L.; Wang, Y.; Hantash, B.M.
Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase
J. Invest. Dermatol.
129
2242-2249
2009
Agaricus bisporus, Homo sapiens
brenda
Olivares, C.; Solano, F.
New insights into the active site structure and catalytic mechanism of tyrosinase and its related proteins
Pigment Cell Melanoma Res.
22
750-760
2009
Gallus gallus, Homo sapiens, Mus musculus, Streptomyces castaneoglobisporus
brenda
Abbas, Q.; Raza, H.; Hassan, M.; Phull, A.R.; Kim, S.J.; Seo, S.Y.
Acetazolamide inhibits the level of tyrosinase and melanin an enzyme kinetic, in vitro, in vivo, and in silico studies
Chem. Biodivers.
14
e1700117
2017
Agaricus bisporus, Danio rerio, Homo sapiens
brenda
Dolinska, M.B.; Wingfield, P.T.; Sergeev, Y.V.
Purification of recombinant human tyrosinase from insect larvae infected with the baculovirus vector
Curr. Protoc. Protein Sci.
89
15.1-6.15.12
2017
Homo sapiens (P14679), Homo sapiens
brenda
Nokinsee, D.; Shank, L.; Lee, V.S.; Nimmanpipug, P.
Estimation of inhibitory effect against tyrosinase activity through homology modeling and molecular docking
Enzyme Res.
2015
262364
2015
Agaricus bisporus, Homo sapiens (P14679), Homo sapiens
brenda
Fogal, S.; Carotti, M.; Giaretta, L.; Lanciai, F.; Nogara, L.; Bubacco, L.; Bergantino, E.
Human tyrosinase produced in insect cells a landmark for the screening of new drugs addressing its activity
Mol. Biotechnol.
57
45-57
2015
Streptomyces antibioticus (P07524), Homo sapiens (P14679), Homo sapiens
brenda
Bin, B.H.; Bhin, J.; Yang, S.H.; Shin, M.; Nam, Y.J.; Choi, D.H.; Shin, D.W.; Lee, A.Y.; Hwang, D.; Cho, E.G.; Lee, T.R.
Membrane-associated transporter protein (MATP) regulates melanosomal pH and influences tyrosinase activity
PLoS ONE
10
e0129273
2015
Homo sapiens
brenda
Zheng, J.; Zhang, R.; Chen, Y.; Ye, X.; Chen, Q.; Shen, D.; Wang, Q.
Synthesis of caffeic acid ester morpholines and their activation effects on tyrosinase
Process Biochem.
62
91-98
2017
Agaricus bisporus, Homo sapiens (P14679)
-
brenda
EXTERNAL LINKS (specific for EC-Number 1.14.18.1)
Transporter Classification Database (TCDB): 9.B.423.1.1
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Release 2023.1 (January 2023)
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