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Disease on EC 1.14.15.4 - steroid 11beta-monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
11beta-hydroxysteroid dehydrogenase (nad+) deficiency
Endocrine causes of hypertension.
11beta-hydroxysteroid dehydrogenase deficiency
Epidemiologic study of adrenal gland disorders in Japan.
Steroid metabolism in metabolic syndrome X.
17alpha-hydroxyprogesterone deacetylase deficiency
Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency.
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.
3(or 17)beta-hydroxysteroid dehydrogenase deficiency
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
Congenital adrenal hyperplasia in pregnancy.
Congenital adrenal hyperplasia in Turkey: a review of 273 patients.
Congenital adrenal hyperplasia.
Defects in steroidogenic enzymes. Discrepancies between clinical steroid research and molecular biology results.
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
Hyperandrogenism in female adolescents.
3beta-hydroxy-delta5-steroid dehydrogenase deficiency
Comprehensive genotyping of Turkish women with hirsutism.
46, XX Disorders of Sex Development
[A case of female pseudohermaphroditism caused by adrenal deficiency in 21-hydroxylase and 11-hydroxylase.]
Acidosis
[The human genome--chromosome 8]
Acidosis, Renal Tubular
[The human genome--chromosome 8]
Acne Vulgaris
Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency.
Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
[Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
Acromegaly
CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.
Addison Disease
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Epidemiologic study of adrenal gland disorders in Japan.
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
[Should etomidate still be used?]
Adenocarcinoma
Down-regulation of D2 dopamine receptor and increased protein kinase Cmu phosphorylation in aldosterone-producing adenoma play roles in aldosterone overproduction.
Adenoma
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
A patient with preclinical Cushing's syndrome and excessive DHEA-S secretion having unilateral adrenal carcinoma and contralateral adenoma.
A role for the NGFI-B family in adrenal zonation and adrenocortical disease.
Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA).
ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma.
ACTH-independent macronodular adrenocortical hyperplasia: immunohistochemical and in situ hybridization studies of steroidogenic enzymes.
Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism.
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Adrenocortical zonation in humans under normal and pathological conditions.
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.
Aldosterone-producing adrenal cortical cancer: a case report and analysis of steroidogenic enzymes in the tumor.
Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.
Association of Lys173Arg polymorphism with CYP11B2 expression in normal adrenal glands and aldosterone-producing adenomas.
Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms.
Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.
Characterization of a mutated KCNJ5 gene, G387R, in unilateral primary aldosteronism.
Characterization of adrenal autonomy in Cushing's syndrome: a comparison between in vivo and in vitro responsiveness of the adrenal gland.
Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma.
Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome.
Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.
Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism.
Different expression of 11?-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases.
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Editorial Comment from Dr Fang to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Editorial Comment from Dr Ishidoya to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas.
Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II.
Evaluation of Cortisol Production in Aldosterone-Producing Adenoma.
Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.
Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.
Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism.
Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia.
Genetic and Histopathologic Inter-Tumor Heterogeneity in Primary Aldosteronism.
Genetic, Cellular, and Molecular Heterogeneity in Adrenals With Aldosterone-Producing Adenoma.
Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis.
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Hyperaldosteronism in pregnancy.
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.
Identification of Somatic Mutations in CLCN2 in Aldosterone-Producing Adenomas.
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism.
Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism.
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome.
Mast Cell Hyperplasia is Associated with Aldosterone Hypersecretion in a subset of Aldosterone-Producing Adenomas.
miRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma.
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Mutations in CYP11B1 gene converting 11beta-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas.
New aspects on primary aldosteronism.
Normoaldosteronemic aldosterone-producing adenoma: immunochemical characterization and diagnostic implications.
Nuclear imaging in the diagnosis of primary aldosteronism.
Partial Adrenalectomy Carries a Considerable Risk of Incomplete Cure in Primary Aldosteronism.
Pathology of Aldosterone Biosynthesis and its Action.
Pathophysiological roles of the adrenal renin-angiotensin system in patients with primary aldosteronism.
Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Predictors of successful outcome after adrenalectomy for primary aldosteronism.
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Presence of Subclinical Hypercortisolism in Clinical Aldosterone-Producing Adenomas Predicts Lower Clinical Success.
Primary aldosteronism due to bilateral micronodular hyperplasia and concomitant subclinical Cushing's syndrome: A case report.
Primary Aldosteronism: KCNJ5 Mutations and Adrenocortical Cell Growth.
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma.
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism.
Steroid Profiling as an Additional Tool to Confirm One-Sided Hormone Overproduction in Primary Aldosteronism: A Case Report.
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.
The expression of messenger RNA for ADP-ribosyl cyclase in aldosterone-producing adenomas.
The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.
Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma.
Zone-specific localization of cytochrome P45011B1 in human adrenal tissue by PCR-derived riboprobes.
[Mineralocorticoid syndromes and hypertension]
Adrenal Cortex Neoplasms
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma.
Adrenal Hyperplasia, Congenital
11 Beta-hydroxylase deficiency congenital adrenal hyperplasia: update of prenatal diagnosis.
11 beta-hydroxylase deficiency: management of a difficult case by laparoscopic bilateral adrenalectomy.
11-deoxycortisol in amniotic fluid: prenatal diagnosis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion.
46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical Features.
A 5-year-old boy with cryptorchidism and pubic hair: investigation and management of apparent male disorders of sex development in mid-childhood.
A case of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency presenting as hemorrhagic stroke.
A case of congenital adrenal hyperplasia with concomitant abnormalities of steroid 21- and 11 beta-hydroxylase activities.
A Chinese patient with 11?-hydroxylase deficiency due to novel compound heterozygous mutation in CYP11B1 gene: a case report.
A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency.
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin.
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report.
A novel missense mutation, GGC(Arg454) --> TGC(Cys), of CYP11B1 gene identified in a Chinese family with steroid 11beta-hydroxylase deficiency.
A Novel Mutation in the CYP11B1 Gene Causes Steroid 11?-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy.
A novel nonsense mutation in the Cyp11B1 gene from a subject with the steroid 11beta-hydroxylase form of congenital adrenal hyperplasia.
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
A pilot study for neonatal screening of congenital adrenal hyperplasia due to 21-hydroxylase and 11-beta-hydroxylase deficiency in Campania region.
Abnormalities of aldosterone synthesis and action in children.
Absence of steroid biosynthetic defects in heterozygote individuals for classic 11 beta-hydroxylase deficiency due to a R448H mutation in the CYP11B1 gene.
ACTH receptor blockade: a novel approach to treat congenital adrenal hyperplasia, or Cushing's disease.
Acute adrenal crisis complicating hypertensive congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
Aldosterone synthase deficiency and related disorders.
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency.
Androgen metabolism in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Bilateral adrenalectomy for severe hypertension in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency: Long term follow-up.
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1.
Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Clinical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11).
Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia.
Combined 21-hydroxylase and 11beta-hydroxylase deficiency: patient report and molecular basis.
Compound heterozygosity of a novel Q73X mutation and a known R141X mutation in CYP11B1 resulting in 11?-hydroxylase deficiency in a Chinese boy with congenital adrenal hyperplasia.
Congenital adrenal hyperplasia 11beta-hydroxylase deficiency: two cases managed with bilateral adrenalectomy.
Congenital adrenal hyperplasia caused by 11 beta-hydroxylase deficiency with onset of symptoms after one spontaneous pregnancy.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency in Saudi Arabia: clinical and biochemical characteristics.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency: final diagnosis in adult age in three patients.
Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency in a Tunisian family.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: description of a new mutation, R384X.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency--insights from two novel CYP11B1 mutations (p.M92X, p.R453Q).
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency-Compound heterozygous mutations of a prevalent and two novel CYP11B1 mutations.
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene.
Congenital adrenal hyperplasia due to 11-hydroxylase enzyme deficiency in three siblings. A brief report.
Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency.
Congenital adrenal hyperplasia family studies using the short ACTH test.
Congenital adrenal hyperplasia in a Nigerian child with a novel compound heterozygote mutation in CYP11B1.
Congenital adrenal hyperplasia in Turkey: a review of 273 patients.
Congenital adrenal hyperplasia secondary to 11beta-hydroxylase deficiency in a domestic cat.
Congenital adrenal hyperplasia with 11 beta-hydroxylase deficiency.
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Congenital adrenal hyperplasia with 11-hydroxylase deficiency. A case report and contribution to diagnosis.
Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.
Correction: Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Cortisol production rate in children by gas chromatography/mass spectrometry using [1,2,3,4-13C]cortisol.
Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family.
CYP11B1 mutations causing congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.
Deoxycorticosterone, 11 beta-hydroxylase and the adrenal cortex.
Diabetes mellitus associated with late onset congenital adrenal hyperplasia: coincidence or causality?
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Diagnosis of congenital adrenal hyperplasia with 11-hydroxylase deficiency by determination of tetrahydro-11-desoxycortisol in urine.
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
Difficulties in the diagnosis of congenital adrenal hyperplasia in early infancy: the 11 beta-hydroxylase defect.
Disorders of steroid 11 beta-hydroxylase isozymes.
Disorders of steroid 17 alpha-hydroxylase deficiency.
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia.
Divergent gender identity in three siblings with 46XX karyotype and severely virilizing congenital adrenal hyperplasia caused by a novel CYP11B1 mutation.
Effect of hydrocortisone dose schedule on adrenal steroid secretion in congenital adrenal hyperplasia.
Evidence for a new biologic pathway of androstenedione synthesis from 11-deoxycortisol.
Evidence for endocrinological abnormalities in heterozygotes for adrenal 11 beta-hydroxylase deficiency of a family with the R448H mutation in the CYP11B1 gene.
Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome.
Familial pericentric inversion chromosome 3 and R448C mutation of CYP11B1 gene in Turkish kindred with 11beta-hydroxylase deficiency.
Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassic and three mutations causing classic 11{beta}-hydroxylase deficiency.
Gender identity in congenital adrenal hyperplasia secondary to 11-hydroxylase deficiency.
Glucocorticoid receptors in patients with congenital adrenal hyperplasia.
Glucocorticoid treatment of girls with congenital adrenal hyperplasia: effects on height, sexual maturation, and fertility.
Growth and pubertal development in patients with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia.
Gynaecomastia in two prepubertal boys with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
High frequency of congenital adrenal hyperplasia (classic 11 beta-hydroxylase deficiency) among Jews from Morocco.
HLA and congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
Hormonal studies in obligate heterozygotes and siblings of patients with 11 beta-hydroxylase deficiency congenital adrenal hyperplasia.
Hyperplasia of adrenal rest tissue causing a retroperitoneal mass in a child with 11 beta-hydroxylase deficiency.
Inherited forms of mineralocorticoid hypertension.
Isosexual precocity: the clinical and etiologic profile.
Kinetics and metabolism of 11-deoxycortisol in a patient with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Male Gender Identity and Reversible Hypokalemic Hypertension in a 46,XX Child with 11-Beta-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Missense mutation in CYP11B1 (CGA[Arg-384]-->GGA[Gly]) causes steroid 11 beta-hydroxylase deficiency.
Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.
Molecular genetics of congenital adrenal hyperplasia.
Mutations in CYP11B1 and congenital adrenal hyperplasia in Moroccan Jews.
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
Neonatal salt loss in the hypertensive form of congenital adrenal hyperplasia.
Neonatal salt-wasting and 11 beta-hydroxylase deficiency in a child carrying a homozygous deletion hybrid CYP11B2 (aldosterone synthase)-CYP11B1 (11 beta-hydroxylase).
New aspects of mineralocorticoid hypertension.
New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia.
No linkage between HLA and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Nonclassic 11 beta-hydroxylase deficiency: report of two patients and review.
Novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Novel homozygous p.Y395X mutation in the CYP11B1 gene found in a Vietnamese patient with 11?-hydroxylase deficiency.
Novel missense mutations, GCC [Ala306]- > GTC [Val] and ACG [Thr318]- > CCG [Pro], in the CYP11B1 gene cause steroid 11beta-hydroxylase deficiency in the Chinese.
Novel mutations in CYP11B1 gene leading to 11 beta-hydroxylase deficiency in Brazilian patients.
Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V.
Over 50 Years of Progress in the Treatment of the Hypertensive Form of Congenital Adrenal Hyperplasia due to Steroid 11-Beta-Hydroxylase Deficiency. Commentary on Simm PJ and Zacharin MR: Successful Pregnancy in a Patient with severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene (Horm Res 2007;68:294-297).
Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man.
Phenotypic, metabolic, and molecular genetic characterization of six patients with congenital adrenal hyperplasia caused by novel mutations in the CYP11B1 gene.
Precocious pseudopuberty due to a rare form of congenital adrenal hyperplasia. Biochemical investigation and pitfalls in interpretation of hormone assays.
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.
Prenatal diagnosis of 11beta-hydroxylase deficiency congenital adrenal hyperplasia.
Progress in molecular-genetic studies on congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Rapid diagnosis of congenital adrenal hyperplasia by high performance liquid chromatography.
Requirement of mineralocorticoid in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Reversed-phase high-performance liquid chromatography separation of adrenal steroids prior to radioimmunoassay: application in congenital adrenal hyperplasia.
Reversible cardiomyopathy caused by an uncommon form of congenital adrenal hyperplasia.
Roux-en-Y gastric bypass in the treatment of non-classic congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).
Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia.
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency.
Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene.
Steroid 11 beta-hydroxylase deficiency and related disorders.
Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other.
Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Steroids and hypertension.
Successful Pregnancy in a Patient with Severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene.
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia.
Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene.
The combination of a novel 2 bp deletion mutation and p.D63H in CYP11B1 cause congenital adrenal hyperplasia due to steroid 11?-hydroxylase deficiency.
Three novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11Beta-hydroxylase deficiency in a moroccan population.
Two intronic variants of CYP11B1 and CYP17A1 disrupt mRNA splicing and cause congenital adrenal hyperplasia (CAH).
Two novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11? hydroxylase deficiency in a Tunisian family.
Two novel mutations in CYP11B1 and modeling the consequent alterations of the translated protein in classic congenital adrenal hyperplasia patients.
Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia.
Uniparental disomy of chromosome 8 leading to homozygosity of a CYP11B1 mutation in a patient with congenital adrenal hyperplasia: Implication for a rare etiology of an autosomal recessive disorder.
Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
[11beta-hydroxylase deficiency: improvement of final height with growth hormone and gonadotropin-releasing hormone analog]
[11beta-hydroxylase deficiency]
[Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
[Congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency. A case report]
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency - different HLA genotypes in 2 brothers]
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
[Congenital adrenal hyperplasia. Presentation of a case and review of the literature]
[Familial congenital adrenal hyperplasia caused by 11 beta-hydroxylase. Failure of prevention of sexual ambiguity and prenatal diagnosis]
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
[Rare forms of female pseudohermaphroditism: when to investigate?]
[Severe form of congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency in a 3-year old boy]
[Variations of production rate of cortisol, corticosterone, aldosterone and desoxycorticosterone in 4 cases of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency]
Adrenal Insufficiency
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
Adrenal Rest Tumor
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours.
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia.
Adrenocortical Adenoma
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Disordered expression of adrenal steroidogenic P450 mRNAs in incidentally discovered nonfunctioning adrenal adenoma.
Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
Expression of CYP11B2 in Aldosterone-Producing Adrenocortical Adenoma: Regulatory Mechanisms and Clinical Significance.
Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.
Extraordinarily high aldosterone, 901.0 ng/dL, in a patient with primary aldosteronism: an insight into the underlying mechanism.
Hypomethylation of CYP11B2 in Aldosterone-Producing Adenoma.
Imaging of adrenal masses with emphasis on adrenocortical tumors.
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome.
MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2.
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma.
Adrenocortical Carcinoma
AT1AA (Angiotensin II Type-1 Receptor Autoantibodies): Cause or Consequence of Human Primary Aldosteronism?
Autocrine-paracrine role of endothelin-1 in the regulation of aldosterone synthase expression and intracellular Ca2+ in human adrenocortical carcinoma NCI-H295 cells.
Autocrine-Paracrine Role of Endothelin-1 in the Regulation of Aldosterone Synthase Expression and Intracellular Ca2+ in Human Adrenocortical Carcinoma NCI-H295 Cells.
Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.
CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells.
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Effects of Adipocyte-derived Factors on the Adrenal Cortex.
PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.
Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways.
Visinin-Like 1 Is Upregulated in Aldosterone-Producing Adenomas With KCNJ5 Mutations and Protects From Calcium-Induced Apoptosis.
Adrenocortical Hyperfunction
Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-? hydroxysteroid dehydrogenase type 1.
[Study of a case of cogenital hypercorticism due to disorder of 11 beta-hydroxylase. Identification of compound "S", desoxycorticosterone and compound "B".]
Adrenogenital Syndrome
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
Adrenogenital syndrome due to 11-beta-hydroxylase deficiency with skeletal abnormalities and pulmonary stenosis.
Congenital adrenal hyperplasia caused by 11 beta-hydroxylase deficiency with onset of symptoms after one spontaneous pregnancy.
Pseudotumor cerebri in a boy with 11-beta-hydroxylase deficiency--a possible relation to rapid steroid withdrawal.
[Diagnosis of the adrenogenital syndrome caused by 11beta-hydroxylase deficiency using gas chromatographic-mass spectrometric analysis of the urinary steroid profile]
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
[PSEUDOHERMAPHRODITISM WITH ADRENOGENITAL SYNDROME AND PARTIAL 11-BETA-HYDROXYLASE DEFICIENCY.]
Albuminuria
[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension]
Alkalosis
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
Alopecia
Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
Urinary steroids in women with androgenic alopecia.
Antley-Bixler Syndrome Phenotype
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.
aromatase deficiency
46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical Features.
Atherosclerosis
FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient mice.
Preliminary studies on human aldosterone synthase (CYP11B2) gene polymorphism, matrix metalloprotease-9, apoptosis, and carotid atherosclerosis plaque size by proton magnetic resonance imaging.
Atrial Fibrillation
A comprehensive meta-analysis on relationship between CYP11B2 rs1799998 polymorphism and atrial fibrillation.
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Association between aldosterone synthase (CYP11B2) -344C/T polymorphism and atrial fibrillation among Han and Kazak residents of the Xinjiang region.
Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.
Association of angiotensin-converting enzyme gene I/D and CYP11B2 gene -344T/C polymorphisms with lone atrial fibrillation and its recurrence after catheter ablation.
Contribution of the ACE (rs1799752) and CYP11B2 (rs1799998) Gene Polymorphisms to Atrial Fibrillation in the Tunisian Population.
CYP11B2 T-344C gene polymorphism and atrial fibrillation: a meta-analysis of 2,758 subjects.
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease.
Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.
Mineralocorticoid receptor, CYP11B2 mRNA expression, and atrial matrix remodelling in patients with atrial fibrillation.
MiR-138-5p is downregulated in patients with atrial fibrillation and reverses cardiac fibrotic remodeling via repressing CYP11B2.
Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
Relationship between CYP11B2-344T>C polymorphsim and atrial fibrillation: A meta-analysis.
[Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation]
[The relation between angiotensin II receptors 1 and 2, and CYP11B2 and atrial structural remodeling in patients with atrial fibrillation]
Brain Ischemia
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia.
[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia].
Breast Neoplasms
A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.
Role of the renin-angiotensin-aldosterone system and the glutathione S-transferase Mu, Pi and Theta gene polymorphisms in cardiotoxicity after anthracycline chemotherapy for breast carcinoma.
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
Bronchial Hyperreactivity
Pharmacological study of bacterial lipopolysaccharide-induced airway hyperresponsiveness in guinea-pigs.
Carcinogenesis
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
Carcinoma
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
Development of a high-throughput assay for aldosterone synthase inhibitors using high-performance liquid chromatography-tandem mass spectrometry.
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Role of the Mevalonate Pathway in Adrenocortical Tumorigenesis.
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Carcinoma, Hepatocellular
Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.
Cardiomegaly
Aldosterone synthase alleles and cardiovascular phenotype in young adults.
Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2.
Human aldosterone synthase gene polymorphism promotes miRNA binding and regulates gene expression.
Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes.
Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.
Cardiomyopathies
A Novel Mutation in the CYP11B1 Gene Causes Steroid 11?-Hydroxylase Deficient Congenital Adrenal Hyperplasia with Reversible Cardiomyopathy.
Cardiomyopathy, Dilated
An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy.
Association between aldosterone synthase (CYP11B2) gene polymorphism and left ventricular volume in patients with dilated cardiomyopathy.
Impact of repeated intravenous bone marrow mesenchymal stem cells infusion on myocardial collagen network remodeling in a rat model of doxorubicin-induced dilated cardiomyopathy.
Reversible cardiomyopathy caused by an uncommon form of congenital adrenal hyperplasia.
[Study on association between aldosterone synthase gene polymorphism and the left ventricular structure and function of patients with dilated cardiomyopathy in China]
Cardiomyopathy, Hypertrophic
DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases.
[Association between aldosterone synthase gene polymorphism and hypertrophic cardiomyopathy]
Cardiotoxicity
Role of the renin-angiotensin-aldosterone system and the glutathione S-transferase Mu, Pi and Theta gene polymorphisms in cardiotoxicity after anthracycline chemotherapy for breast carcinoma.
Cardiovascular Diseases
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.
3-Pyridyl substituted aliphatic cycles as CYP11B2 inhibitors: aromaticity abolishment of the core significantly increased selectivity over CYP1A2.
Aldosterone synthase inhibitors for cardiovascular diseases: A comprehensive review of preclinical, clinical and in silico data.
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
CYP11B2 gene polymorphism among coronary heart disease patients and blood donors in Malaysia.
Development and application of low-cost T-ARMS-PCR assay for AGT and CYP11B1 gene polymorphisms.
DNA Methylation of the Angiotensinogen Gene, AGT, and the Aldosterone Synthase Gene, CYP11B2 in Cardiovascular Diseases.
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer.
[The role of the -344C/T polymorphism of the aldosterone synthase gene (CYP11B2) in cardiovascular diseases]
Carotid Artery Diseases
Preliminary studies on human aldosterone synthase (CYP11B2) gene polymorphism, matrix metalloprotease-9, apoptosis, and carotid atherosclerosis plaque size by proton magnetic resonance imaging.
Catalepsy
Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice.
Cholera
Expression of 11 beta-hydroxylase and 21-hydroxylase in long-term cultures of bovine adrenocortical cells requires extracellular matrix factors.
Interaction of phorbol ester and adrenocorticotropin in the regulation of steroidogenic P450 genes in human fetal and adult adrenal cell cultures.
Regulation of 11 beta- and 17 alpha-hydroxylases in cultured bovine adrenocortical cells: 3', 5'-cyclic adenosine monophosphate, insulin-like growth factor-I, and activators of protein kinase C.
Coinfection
[A case of acute respiratory distress syndrome caused by cryptococcus and cytomegalovirus co-infection after Cushing's syndrome treatment].
Colitis
Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis.
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
Coronary Artery Disease
Angiotensin converting enzyme gene polymorphism is associated with severity of coronary artery disease in men with high total cholesterol levels.
Association between the CYP11B2 gene -344T>C polymorphism and coronary artery disease: a meta-analysis.
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.
Coronary Disease
Analysis of promoter region polymorphism in the aldosterone synthase gene (CYP11B2) as a risk factor for myocardial infarction.
CYP11B2 gene polymorphism among coronary heart disease patients and blood donors in Malaysia.
Genetic variation in the renin-angiotensin-aldosterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease.
corticosterone 18-monooxygenase deficiency
Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.
Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II.
Cryptorchidism
Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization.
[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
Cushing Syndrome
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
Adrenocortical zonation in humans under normal and pathological conditions.
An unusual case of Cushing's syndrome due to ACTH-independent macronodular adrenal hyperplasia.
Assessment of in vitro effects of metyrapone on Leydig cell steroidogenesis.
Benzophenones as xanthone-open model CYP11B1 inhibitors potentially useful for promoting wound healing.
Characterization of adrenal autonomy in Cushing's syndrome: a comparison between in vivo and in vitro responsiveness of the adrenal gland.
Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome.
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (Pyridylmethyl)pyridine type.
Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11?-hydroxylase.
Editorial comment from Dr Fang to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Editorial comment from Dr Ishidoya to increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Endocrine causes of hypertension.
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas.
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Markedly increased expression of cytochrome P-450 17 alpha-hydroxylase (P-450c17) mRNA in adrenocortical adenomas from patients with Cushing's syndrome.
New aspects on primary aldosteronism.
Novel Imidazol-1-ylmethyl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as Potent and Selective CYP11B1 Inhibitors for the Treatment of Cushing's Syndrome.
Optimization of the First Selective Steroid-11?-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Positron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11beta-hydroxylase tracer (11)C-metomidate.
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016).
Therapy of Cushing's syndrome with steroid biosynthesis inhibitors.
[A case of acute respiratory distress syndrome caused by cryptococcus and cytomegalovirus co-infection after Cushing's syndrome treatment].
[Endocrine and neurogenic hypertension in childhood]
[Medical treatment for Cushing's syndrome]
Cysts
Renal Cysts and Nephrocalcinosis in 11 Beta-hydroxylase Deficiency.
Renal Cysts and Nephrocalcinosis in a Patient Deficient in 11 beta-Hydroxylase Enzyme.
Thyroid cysts: a new extra-adrenal site of aldosterone synthase expression and increased aldosterone content.
Dehydration
Aldosterone synthase deficiency type II with hypospadias.
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review.
Dementia
Factors Determining Cognitive Dysfunction in Cerebral Small Vessel Disease.
Diabetes Mellitus
Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
Association between cytochrome P450 promoter polymorphisms and ischemic stroke.
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Diabetes mellitus associated with late onset congenital adrenal hyperplasia: coincidence or causality?
Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus: a modest but significant effect of aldosterone synthase.
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Retraction notice.
Diabetes Mellitus, Type 2
Aldosterone Synthase Inhibition Improves Glucose Tolerance in Zucker Diabetic Fatty (ZDF) Rats.
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus: a modest but significant effect of aldosterone synthase.
Diabetic Nephropathies
Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients.
Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy.
Aldosterone synthase inhibitors: targeting chronic kidney disease and diabetic nephropathy.
Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis.
Mitigating risk of aldosterone in diabetic kidney disease.
Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients.
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Retraction notice.
Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats.
Disorders of Sex Development
A Greek girl with 11?-hydroxylase deficiency due to compound heterozygosity for two novel mutations in CYP11B1 gene.
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Combined 21-hydroxylase and 11beta-hydroxylase deficiency: patient report and molecular basis.
Inborn errors of adrenal steroidogenesis.
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.
[PSEUDOHERMAPHRODITISM WITH ADRENOGENITAL SYNDROME AND PARTIAL 11-BETA-HYDROXYLASE DEFICIENCY.]
Drug-Related Side Effects and Adverse Reactions
Human adrenal CYP11B1: localization by in situ-hybridization and functional expression in cell cultures.
Dwarfism
The use of an adrenocortical 11-beta-hydroxylase inhibitor, (methopyrone) in the differential diagnosis of dwarfism.
[Studies on the pituitary ACTH secretory capacity in children using 11-beta-hydroxylase inhibitor (Metopirone). 2. Diagnostic value in pituitary dwarfism in children]
[The use of an adrenal 11-beta-hydroxylase inhibitor (Metopirone) in the diagnosis of nanism.]
Dwarfism, Pituitary
[Studies on the pituitary ACTH secretory capacity in children using 11-beta-hydroxylase inhibitor (Metopirone). 2. Diagnostic value in pituitary dwarfism in children]
Dyslipidemias
Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
Eclampsia
Correlations of CYP11B2 gene polymorphisms with eclampsia.
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Endocrine System Diseases
Endocrine causes of hypertension.
[Endocrine and neurogenic hypertension in childhood]
Essential Hypertension
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension.
A biallelic gene polymorphism of CYP11B2 predicts increased aldosterone to renin ratio in selected hypertensive patients.
A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension.
A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.
A systemic review of the relationship between aldosterone synthase - 344 C/T polymorphism and hypertension in Han.
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.
Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2.
Aldosterone synthase (CYP11B2)-344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy.
Aldosterone synthase C-344T, angiotensin II type 1 receptor A1166C and 11-? hydroxysteroid dehydrogenase G534A gene polymorphisms and essential hypertension in the population of Odisha, India.
An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects.
Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension.
Association between Aldosterone Synthase CYP11B2 Polymorphism and Essential Hypertension in Chinese: A Meta-Analysis.
Association between single-nucleotide polymorphisms in six hypertensive candidate genes and hypertension among northern Han Chinese individuals.
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Association of aldosterone synthase (CYP11B2 C-344T) gene polymorphism & susceptibility to essential hypertension in a south Indian Tamil population.
Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
Association of echocardiographic left ventricular structure and -344C/T aldosterone synthase gene variant: A meta-analysis.
Association of the -344T/C aldosterone synthase gene variant with essential hypertension.
Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: A case-control study in a Han Chinese population.
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China.
Association of the Human CYP11B2 Gene and Essential Hypertension in Southwest Han Chinese Population: A Haplotype-Based Case-Control Study.
Associations between CYP11B2 gene -344T/C polymorphism and essential hypertension in the Han nationality in Shandong province.
Associations between human aldosterone synthase CYP11B2 (-344T/C) gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension.
Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: a case-control study.
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
CYP11B2 gene polymorphism and essential hypertension among Tibetan, Dongxiang and Han populations from northwest of China.
CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.
Dissecting hypertension: the role of the 'new genetics'.
Effects of the C-344T aldosterone synthase gene variant on preclinical vascular alterations in essential hypertension.
Genetic and functional analyses of aldosterone synthase gene C-344T polymorphism with essential hypertension.
Genetic determinants of human hypertension.
Genetic determination of plasma aldosterone levels in essential hypertension.
Genetically determined enlargement of carotid body evaluated using computed angiotomography.
Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers.
Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension.
Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.
Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China.
Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population.
Interaction of ACE and CYP11B2 Genes on Blood Pressure Response to Hydrochlorothiazide in Han Chinese Hypertensive Patients.
Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension.
Intron-2 conversion polymorphism of the aldosterone synthase gene and the antihypertensive response to angiotensin-converting enzyme inhibitors.
Investigation of major genetic polymorphisms in the Renin-Angiotensin-aldosterone system in subjects with young-onset hypertension selected by a targeted-screening system at university.
Lack of association of CYP11B2-344C/T polymorphism with essential hypertension: a meta-analysis.
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.
Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension.
Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol.
Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
Steroid metabolism in metabolic syndrome X.
Structural analysis and evaluation of the aldosterone synthase gene in hypertension.
Structure-function relationships of aldosterone synthase and 11 beta-hydroxylase enzymes: implications for human hypertension.
The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese.
The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.
[Association analysis of the essential hypertension susceptibility genes in adolescents: Kangwha study]
[Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with essential hypertension in Mongolian nationality].
[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension]
[Association of aldosterone synthase gene -344T/C polymorphism with plasma aldosterone and angiotensin II concentration in hypertensive patients]
[Association of polymorphisms in ACE and CYP11B2 genes with antihypertensive effects of hydrochlorothiazide]
[Association of the -344T/C polymorphism of the aldosterone synthase gene with essential hypertension]
[Association of the T(-344)C polymorphism of aldosterone synthase gene CYP11B2 with essential hypertension in Xinjiang Kazakh isolated group.]
[Correlativity between the polymorphisms of aldosterone synthase gene, Hind III restriction site on Y chromosome and essential hypertension]
[Effect of CYP11B2 gene -344T/C polymorphism on renin-angiotensin-aldosterone system activity and blood pressure response to hydrochlorothiazide].
[Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension]
[Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population]
[Meta analysis on the association of CYP11B2 gene polymorphism and essential hypertension in Chinese Han population].
[Relationship between aldosterone synthase gene (CYPJLB2) polymorphisms and essential hypertension in a northern Chinese Han population]
[Single nucleotide polymorphisms of three candidate genes in essential hypertension]
[Specifics of distribution of polymorphic markers of the renin-angiotensin-system genes, relation to ventricular hypertrophy in patients with essential hypertension of Uzbek nationality]
[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy]
Gastroenteritis
Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Genetic Diseases, Inborn
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
Aldosterone synthase (CYP11B2) deficiency among Palestinian infants: Three novel variants and genetic heterogeneity.
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other.
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Glioma
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.
Glomerulonephritis
Association of aldosterone synthase (CYP11B2) gene -344T/C polymorphism with the risk of primary chronic glomerulonephritis in the Polish population.
Glomerulonephritis, IGA
Expression of aldosterone synthase gene in IgA nephropathy (IgAN).
Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy.
Genetic polymorphisms of the renin-angiotensin-aldosterone system in Chinese patients with end-stage renal disease secondary to IgA nephropathy.
Impact of Aldosterone Synthase Gene C-344T Polymorphism on IgA Nephropathy.
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
Retracted: Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy.
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
RETRACTED: Role of renin-angiotensin-aldosterone system inhibitors in radiation nephropathy.
Retraction notice.
Glomerulosclerosis, Focal Segmental
Influence of aldosterone synthase gene C-344T polymorphism on focal segmental glomerulosclerosis.
Gynecomastia
11-Hydroxylase deficiency as a cause of pre-pubertal gynecomastia.
Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies.
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency.
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Hearing Loss, Bilateral
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
Hearing Loss, Sensorineural
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
Heart Diseases
Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function.
Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease.
Heart Failure
1-Phenylsulfinyl-3-(pyridin-3-yl)naphthalen-2-ols: a new class of potent and selective aldosterone synthase inhibitors.
A novel aldosterone synthase inhibitor ameliorates mortality in pressure-overload mice with heart failure.
A patent review of aldosterone synthase inhibitors (2014-present).
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
Aldosterone synthase inhibition in humans.
Aldosterone synthase promoter polymorphism predicts outcome in African Americans with heart failure: results from the A-HeFT Trial.
An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy.
Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).
Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.
Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosis.
Emerging role of pharmacogenomics in heart failure.
Expression of aldosterone synthase gene in failing human heart: quantitative analysis using modified real-time polymerase chain reaction.
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level.
Imidazopyridyl compounds as aldosterone synthase inhibitors.
Novel therapies in acute and chronic heart failure.
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Pharmacophore Modeling and
Prognostic Value of Different Allelic Polymorphism of Aldosterone Synthase Receptor in a Congestive Heart Failure European Continental Ancestry Population.
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
TaqMan real-time PCR quantification: conventional and modified methods.
TaqMan Real-Time PCR Quantification: Conventional and Modified Methods.
The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Toward a broader understanding of aldosterone in congestive heart failure.
Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure.
Heart Failure, Systolic
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure.
HELLP Syndrome
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Hemorrhagic Stroke
A case of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency presenting as hemorrhagic stroke.
Herpes Simplex
Construction of gene therapy vectors targeting adrenocortical cells: enhancement of activity and specificity with agents modulating the cyclic adenosine 3',5'-monophosphate pathway.
Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.
Herpes Zoster
'Treasure your exceptions': what we can learn from autosomal-dominant inherited forms of hypertension.
11 beta-Hydroxylase activity in glucocorticoid suppressible hyperaldosteronism: lessons for essential hypertension?
11 beta-Hydroxylase gene expression in the rat adrenal cortex.
11?-Hydoxylase Inhibitors Protect Against Seizures in Mice by Increasing Endogenous Neurosteroid Synthesis.
18-Ethynyl-deoxycorticosterone inhibition of steroid production is different in freshly isolated compared to cultured calf zona glomerulosa cells.
19-Acetylenic-deoxycorticosterone inhibits 19-hydroxylase and 11 beta-hydroxylase activities in dispersed bovine zona fasciculata cells.
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role.
A role for steroid hormones in the variability of blood pressure determination.
Abnormality of aldosterone and cortisol late pathways in glucocorticoid-remediable aldosteronism.
ACTH and PRL sensitivity of highly differentiated cell lines obtained by adrenocortical targeted oncogenesis.
Acute and chronic regulation of aldosterone production.
Adrenal cortex tissue homeostasis and zonation: A WNT perspective.
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice.
Adrenocortical zonation in humans under normal and pathological conditions.
Adrenocortical-specific transgene expression directed by steroid hydroxylase gene promoters.
Adrenocorticotropic hormone stimulates CYP11B1 gene transcription through a mechanism involving AP-1 factors.
Age-Related Autonomous Aldosteronism.
Aldosterone biosynthesis in mitochondria of isolated zones of adrenal cortex.
Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications.
Aldosterone: the minority hormone of the adrenal cortex.
Altered 11 beta-hydroxylase activity in glucocorticoid-suppressible hyperaldosteronism.
Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements.
Angiotensin stimulates the expression of interferon-inducible genes in H295R cells.
Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.
Baboon CYP11B1: the localization and catalytic activity in baboon adrenal tissue.
Biphasic Time Course of the Changes in Aldosterone Biosynthesis Under High Salt Conditions in Dahl Salt-Sensitive Rats.
Blood pressure response to angiotensin II is enhanced in obese Zucker rats and is attributed to an aldosterone-dependent mechanism.
Ca(2+)-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases.
Calcineurin Mediates The Angiotensin II-induced Aldosterone Synthesis in the Adrenal Glands by Upregulation of Transcription of The CYP11B2 Gene.
Calcium regulates human CYP11B2 transcription.
Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model.
Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism.
Changes in the glomerulosa cell phenotype during adrenal regeneration in rats.
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation.
Chimeric CYP11B2/CYP11B1 causing 11?-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.
Chronic angiotensin treatment stimulates the growth and the 11 beta-hydroxylase activity of rat zona fasciculata cells.
Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC.
Comparative CYP-dependent binding of the adrenocortical toxicants 3-methylsulfonyl-DDE and o,p'-DDD in Y-1 adrenal cells.
Conditionally immortalized adrenocortical cell lines at undifferentiated states exhibit inducible expression of glucocorticoid-synthesizing genes.
Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.
Corticosteroid synthesis in the central nervous system.
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
Csk Regulates Blood Pressure by Controlling the Synthetic Pathways of Aldosterone.
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.
Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.
Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11beta-hydroxylase.
Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.
Development of monoclonal antibodies against the human 3?-hydroxysteroid dehydrogenase/isomerase isozymes.
Dietary potassium supplementation and sodium restriction stimulate aldosterone synthase but not 11 beta-hydroxylase P-450 messenger ribonucleic acid accumulation in rat adrenals and require angiotensin II production.
Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.
Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion.
Disordered CYP11B2 Expression in Primary Aldosteronism.
Disorders of steroid 11beta-hydroxylase isozymes.
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.
Does aldosterone play a significant role for regulation of vascular tone?
Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase.
Effects of chloramphenicol on the long term trophic action of ACTH on rat adrenocortical cells: a combined stereological and enzymological study.
Effects of long term stimulation of ACTH and angiotensin II-secretions on the rat adrenal cortex.
Expression of aldosterone synthase CYP11B2 was inversely correlated with longevity.
Gene conversion in the CYP11B2 gene encoding P450c11AS is associated with, but does not cause, the syndrome of corticosterone methyloxidase II deficiency.
Genetic and Histopathologic Inter-Tumor Heterogeneity in Primary Aldosteronism.
Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.
Glucocorticoid remediable aldosteronism: a case report.
Glucocorticoid-remediable aldosteronism.
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
Immunohistochemistry of the adrenal in primary aldosteronism.
In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion.
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal.
Induction of steroidogenic enzymes by potassium in cultured rat zona glomerulosa cells depends on calcium influx and intact protein synthesis.
Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells.
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.
Investigations on the effects of long-term administration of a methionine-enkephalin analogue on the adrenal zona fasciculata of rats treated with dexamethasone or dexamethasone and ACTH.
Involvement of an AP-1 complex in zone-specific expression of the CYP11B1 gene in the rat adrenal cortex.
Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex.
Late steps of aldosterone biosynthesis: sheep are not rats.
Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes.
Localization of the gene transcripts of 11 beta-hydroxylase and aldosterone synthase in the rat adrenal cortex by in situ hybridization.
Mass Spectrometry Imaging Establishes 2 Distinct Metabolic Phenotypes of Aldosterone-Producing Cell Clusters in Primary Aldosteronism.
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
New aspects on primary aldosteronism.
New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia.
OS067. VEGF, a novel stimulator of aldosterone production.
P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities.
Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man.
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Pathogenesis and treatment of primary aldosteronism.
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Potassium induces multiple steroidogenic enzymes in cultured rat zona glomerulosa cells.
Pref-1, SF-1 and adrenocortical zonation.
Primary Aldosteronism in the Elderly.
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Rat glomerulosa cells in primary culture and E. coli lipopolysaccharide action.
Regulation of adrenal steroidogenesis during chronic stress.
Regulation of aldosterone biosynthesis: the end of the road?
Regulation of aldosterone in the 7-day-old rat.
Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members.
Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium.
Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists.
Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
Role of rat adrenal antioxidant defense systems in the aldosterone turn-off phenomenon.
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).
Separate induction of the two isozymes of cytochrome P-450(11) beta in rat adrenal zona glomerulosa cells.
Sodium restriction increases aldosterone biosynthesis by increasing late pathway, but not early pathway, messenger ribonucleic acid levels and enzyme activity in normotensive rats.
Stable expression of rat cytochrome P450 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) in MA-10 cells.
Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Structure of an ovine CYP11B1 gene.
Studies of adrenal steroidogenic enzymes in guinea pigs.
Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects.
TASK1 and TASK3 Potassium Channels: Determinants of Aldosterone Secretion and Adrenocortical Zonation.
The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity.
The Herbicide Atrazine Potentiates Angiotensin II-Induced Aldosterone Synthesis and Release From Adrenal Cells.
The hybrid rat cytochrome P450 containing the first 5 exons of the CYP11B1 and last 4 exons from the CYP11B2 enzyme retains 11 beta-hydroxylase activity, but the alternative hybrid is inactive.
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.
The regulation of aldosterone synthase expression.
The use of high-pressure liquid chromatography in the simultaneous assay of 11beta-hydroxylase and 18-hydroxylase in zona fasciculata-reticularis tissue of the rat adrenal cortex.
Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.
Two types of cytochrome P-450(11 beta) in rat adrenals: separate regulation of gene expression.
Two-pore domain potassium channels in the adrenal cortex.
Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription.
Unique cases of unilateral hyperaldosteronemia due to multiple adrenocortical micronodules, which can only be detected by selective adrenal venous sampling.
Urotensin II Exerts Pressor Effects By Stimulating Renin And Aldosterone Synthase Gene Expression.
Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production.
Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma.
Zona glomerulosa-specific factor: cloning and function.
Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex.
Zone-specific expression of aldosterone synthase cytochrome P-450 and cytochrome P-45011 beta in rat adrenal cortex: histochemical basis for the functional zonation.
Zone-specific regulation of two messenger RNAs for P450c11 in the adrenals of pregnant and nonpregnant rats.
[Construction of transgenic mice with specific Cre recombinase expression in the zona fasciculata in adrenal cortex].
[The mechanisms of corticoids biosynthesis revealed by immunohistochemistry and in situ hybridization]
Hirsutism
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
Comprehensive genotyping of Turkish women with hirsutism.
Congenital adrenal hyperplasia.
Late-onset congenital adrenal hyperplasia in women with hirsutism.
Serum cortisol and 11-desoxycortisol levels in hirsute premenopausal women.
The prevalence of non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency among hirsute women in a Turkish population.
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
Hyperaldosteronism
'Treasure your exceptions': what we can learn from autosomal-dominant inherited forms of hypertension.
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension.
11 beta-Hydroxylase activity in glucocorticoid suppressible hyperaldosteronism: lessons for essential hypertension?
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
A chimeric CYP11B1/CYP11B2 gene in glucocorticoid-insuppressible familial hyperaldosteronism.
A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes Familial Hyperaldosteronism type I.
A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension.
A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.
A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism.
A novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism.
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22).
Abnormality of aldosterone and cortisol late pathways in glucocorticoid-remediable aldosteronism.
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Adrenalectomy completely cured hypertension in familial hyperaldosteronism type I patients with somatic KCNJ5 mutation.
Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions.
Aldosterone secretion a molecular perspective.
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.
Aldosterone synthase gene in patients suffering from hyperaldosteronism.
Aldosterone synthase inhibition in humans.
Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism.
Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications.
Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation.
Altered 11 beta-hydroxylase activity in glucocorticoid-suppressible hyperaldosteronism.
Association of CYP11B2 polymorphisms with susceptibility to primary aldosteronism: a meta-analysis.
Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms.
Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.
Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2.
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.
Computational analysis of functional single nucleotide polymorphisms associated with the CYP11B2 gene.
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation.
CYP11B2 gene polymorphisms in idiopathic hyperaldosteronism.
Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.
Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism.
Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
Different expression of 11?-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.
Disordered CYP11B2 Expression in Primary Aldosteronism.
Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3.
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
DNA Methylation of Steroidogenic Enzymes in Benign Adrenocortical Tumors: New Insights in Aldosterone-Producing Adenomas.
Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase.
Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.
Endocrine causes of hypertension.
Evidence for persistent dysfunction of wild-type aldosterone synthase gene in glucocorticoid-treated familial hyperaldosteronism type I.
Expression of aldosterone synthase and adrenocorticotropic hormone receptor in adrenal incidentalomas from normotensive and hypertensive patients: Distinguishing subclinical or atypical primary aldosteronism from adrenal incidentaloma.
Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism.
Familial hyperaldosteronism type II: description of a large kindred and exclusion of the aldosterone synthase (CYP11B2) gene.
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension.
Genetic alterations in patients with primary aldosteronism.
Genetic analysis of aldosterone synthase in patients with idiopathic hyperaldosteronism.
Genetic aspects of primary hyperaldosteronism.
Genetic causes of primary aldosteronism.
Genetic determinants of human hypertension.
Genetic determination of human essential hypertension.
Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.
Genetic study of patients with dexamethasone-suppressible aldosteronism without the chimeric CYP11B1/CYP11B2 gene.
Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigree.
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
Glucocorticoid-suppressible hyperaldosteronism: effects of crossover site and parental origin of chimaeric gene on phenotypic expression.
Haplotype analysis of CYP11B2.
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Hyper- and hypoaldosteronism.
Hyperaldosteronism in pregnancy.
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Immunohistochemistry for aldosterone synthase CYP11B2 and matrix-assisted laser desorption ionization imaging mass spectrometry for in-situ aldosterone detection.
Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.
Immunohistochemistry of the Human Adrenal CYP11B2 in Normal Individuals and in Patients with Primary Aldosteronism.
Impact of immunohistochemistry on the diagnosis and management of primary aldosteronism: An important tool for improved patient follow-up.
In familial hyperaldosteronism type I, hybrid gene-induced aldosterone production dominates that induced by wild-type genes.
Low-renin hypertension: more common than we think?
Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy?
Monogenic low renin hypertension.
Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.
Mutations in CYP11B1 gene converting 11beta-hydroxylase into an aldosterone-producing enzyme are not present in aldosterone-producing adenomas.
Neonatal salt-wasting and 11 beta-hydroxylase deficiency in a child carrying a homozygous deletion hybrid CYP11B2 (aldosterone synthase)-CYP11B1 (11 beta-hydroxylase).
New aspects on primary aldosteronism.
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism: comparison with the 11{beta}-hydroxylase inhibitor metyrapone.
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome).
Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.
Positron emission tomography imaging of adrenal masses: (18)F-fluorodeoxyglucose and the 11beta-hydroxylase tracer (11)C-metomidate.
Postoperative differentiation between unilateral adrenal adenoma and bilateral adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene CYP11B2.
Predictors of successful outcome after adrenalectomy for primary aldosteronism.
Primary Aldosteronism: Where Are We Now? Where to from Here?
Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology.
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation.
Rapid diagnosis and identification of cross-over sites in patients with glucocorticoid remediable aldosteronism.
Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism.
Sequential comparison of aldosterone synthase inhibition and mineralocorticoid blockade in patients with primary aldosteronism.
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas.
Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma.
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
The angiotensin type 2 receptor in the human adrenocortical zona glomerulosa and in aldosterone-producing adenoma: low expression and no functional role.
The chimeric gene linked to glucocorticoid-suppressible hyperaldosteronism encodes a fused P-450 protein possessing aldosterone synthase activity.
The establishment of a novel high-throughput screening system using RNA-guided genome editing to identify chemicals that suppress aldosterone synthase expression.
The genetic basis of hypertension.
The neurohormonal natural history of essential hypertension: towards primary or tertiary aldosteronism?
The Role of the CYP11B2 Promoter Polymorphism in the Diagnosis of Primary Aldosteronism.
[11-beta-hydroxylase deficiency and glucocorticoid-sensitive hyperaldosteronism]
[Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]
[Endocrine and neurogenic hypertension in childhood]
[Mineralocorticoid syndromes and hypertension]
[Primary aldosteronism: new insights into familial forms].
[Progress on genetic basis of primary aldosteronism].
Hyperalgesia
Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain.
Hyperandrogenism
11 beta-hydroxylase deficiency in hyperandrogenism.
A prevalent and three novel mutations in CYP11B1 gene identified in Chinese patients with 11-beta hydroxylase deficiency.
Hyperandrogenism: new insights into etiology, diagnosis, and therapy.
Late onset adrenocortical hydroxylase deficiencies associated with menstrual dysfunction.
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Hyperglycemia
Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor.
Hyperhomocysteinemia
Factors Determining Cognitive Dysfunction in Cerebral Small Vessel Disease.
Hyperkalemia
Abnormalities of aldosterone synthesis and action in children.
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene.
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review.
Disorders of steroid 11 beta-hydroxylase isozymes.
Mitigating risk of aldosterone in diabetic kidney disease.
Hyperphosphatemia
Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells.
Hyperpituitarism
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
Hyperprolactinemia
Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats.
Hypersensitivity
Aldosterone Synthase in Peripheral Sensory Neurons Contributes to Mechanical Hypersensitivity during Local Inflammation in Rats.
Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.
Hypertension
-344C/T polymorphism of CYP11B2 gene in Italian patients with idiopathic low renin hypertension.
-344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency.
A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function.
A new genetic test for familial hyperaldosteronism type I aids in the detection of curable hypertension.
A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report.
A patent review of aldosterone synthase inhibitors (2014-present).
A prevalent and three novel mutations in CYP11B1 gene identified in Chinese patients with 11-beta hydroxylase deficiency.
A role for steroid hormones in the variability of blood pressure determination.
A role for the NGFI-B family in adrenal zonation and adrenocortical disease.
A systemic review of the relationship between aldosterone synthase - 344 C/T polymorphism and hypertension in Han.
A ubiquitin-proteasome inhibitor bortezomib suppresses the expression of CYP11B2, a key enzyme of aldosterone synthesis.
A/C1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study.
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.
ACTH and Polymorphisms at Steroidogenic Loci as Determinants of Aldosterone Secretion and Blood Pressure.
Acute adrenal crisis complicating hypertensive congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension.
Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients.
Aldosterone synthase alleles and cardiovascular phenotype in young adults.
Aldosterone synthase gene (CYP11B2) C-334T polymorphism, ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama Study.
Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population.
Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs.
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension.
Aldosterone synthase inhibition for the treatment of hypertension and the derived mechanistic requirements for a new therapeutic strategy.
Aldosterone synthase inhibition in humans.
Aldosterone synthase inhibition in hypertension.
Aldosterone synthase inhibitors in hypertension: current status and future possibilities.
Aldosterone synthase promoter polymorphism predicts outcome in African Americans with heart failure: results from the A-HeFT Trial.
Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals.
Allele, Genotype and Haplotype Structures of Functional Polymorphic Variants in Endothelial Nitric Oxide Synthase (eNOS), Angiotensinogen (ACE) and Aldosterone Synthase (CYP11B2) Genes in Healthy Pregnant Women of Indian Ethnicity.
Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency.
Analysis of the Aldosterone Synthase (CYP11B2) and 11?-Hydroxylase (CYP11B1) Genes.
Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia.
Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.
Association between renin-angiotensin-aldosterone system-related genes and blood pressure in a Korean population.
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals.
Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion.
Association of polymorphisms of CYP11B2 gene -344C/T and ACE gene I/D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension.
Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke.
Association of the -344T/C aldosterone synthase gene variant with essential hypertension.
Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis.
Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China.
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Atrial natriuretic peptide and aldosterone synthase gene in essential hypertension: a case-control study.
Bilateral adrenalectomy for severe hypertension in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency: Long term follow-up.
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1.
Blood pressure in relation to three candidate genes in a Chinese population.
Carotid and femoral intima-media thickness in relation to three candidate genes in a Caucasian population.
Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats.
Central neuromodulatory pathways regulating sympathetic activity in hypertension.
Characterization of the enzyme involved in the production of 19-Nor-deoxycorticosterone in hamster.
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.
Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Congenital adrenal hyperplasia causing hypertension: an illustrative review.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Congenital adrenal hyperplasia due to 11-hydroxylase enzyme deficiency in three siblings. A brief report.
Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.
Contribution of Four Polymorphisms in Renin-Angiotensin-Aldosterone-Related Genes to Hypertension in a Thai Population.
Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2.
CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly.
CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension.
CYP11B2 gene polymorphisms and hypertension in highlanders accustomed to high salt intake.
CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study.
Defects in cortisol metabolism causing low-renin hypertension.
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
Development and application of low-cost T-ARMS-PCR assay for AGT and CYP11B1 gene polymorphisms.
Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Discovery of Potential Inhibitors of Aldosterone Synthase from Chinese Herbs Using Pharmacophore Modeling, Molecular Docking, and Molecular Dynamics Simulation Studies.
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.
Disorders of steroid 11 beta-hydroxylase isozymes.
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
Distribution and phenotypic expression of mineralocorticoid receptor and CYP11B2 T-344C polymorphisms in a Taiwanese hypertensive population.
Dopamine and the kidney: a role in hypertension?
Dysregulation of adrenal 11 beta-hydroxylase activity in hypertensive subjects: usefulness of the ACTH 1-17 stimulation test.
Editorial Comment from Dr Fang to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Editorial Comment from Dr Ishidoya to Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.
Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial.
Effects of alcohol on blood pressure and production of vascular aldosterone and corticosterone.
Effects of cholic acid on blood pressure and production of vascular aldosterone and corticosterone.
Effects of glycyrrhizin on production of vascular aldosterone and corticosterone.
Efficacy and safety of LCI699 for hypertension: a meta-analysis of randomized controlled trials and systematic review.
Endocrine causes of hypertension.
Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction.
Factors Determining Cognitive Dysfunction in Cerebral Small Vessel Disease.
Familial hyperaldosteronism.
Functional effects of genetic variants in the 11beta-hydroxylase (CYP11B1) gene.
Gene variants of aldosterone synthase and hypertension.
Genetic approach to diagnostic and therapeutic decisions in human hypertension.
Genetic aspects of congenital adrenal hyperplasia.
Genetic determinants of human hypertension.
Genetic determination of human essential hypertension.
Genetic Influence on Baroreflex Sensitivity in Normotensive Young Men.
Genetic polymorphism of CYP11B2 gene and hypertension in Japanese.
Genetic predisposition to salt-sensitivity: a systematic review.
Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.
Genetic susceptibility to salt-sensitive hypertension in a Han Chinese population: a validation study of candidate genes.
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.
Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion.
Genetic variation in P450c11AS in Chilean patients with low renin hypertension.
Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigree.
Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia.
Haplotype analysis of CYP11B2.
Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.
Haplotype-based case-control study of the human CYP11B2 gene and essential hypertension in Yi and Hani minorities of China.
Haplotypes of aldosterone synthase (CYP11B2) gene in the general population of Japan: the Ohasama study.
Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated with stage-2 hypertension in northern Han Chinese.
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis.
High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells.
High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.
HindIII(+/-) Polymorphism of the Y Chromosome, Blood Pressure, and Serum Lipids: No Evidence of Association in Three White Populations.
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Hormonal hypertension in children: 11beta-hydroxylase deficiency and apparent mineralocorticoid excess.
Human aldosterone synthase gene polymorphism promotes miRNA binding and regulates gene expression.
Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level.
Human CYP11B2 (aldosterone synthase) maps to chromosome 8q24.3.
Hyperaldosteronism in pregnancy.
Hypertension and oedema caused by cortexone hyperproduction and cured by monolateral adrenalectomy. Case report.
Hypertension in a neonate with 11 beta-hydroxylase deficiency.
Hypertension in a patient with aldosterone deficiency.
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Imidazopyridyl compounds as aldosterone synthase inhibitors.
Impact of Aldosterone Synthase Gene C-344T Polymorphism on IgA Nephropathy.
Impact of renin-angiotensin-aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension.
Inborn errors of adrenal steroidogenesis.
Influence of aldosterone synthase gene C-344T polymorphism on focal segmental glomerulosclerosis.
Influence of CYP11B2 gene polymorphism on the prevalence of hypertension and the blood pressure in Japanese men: interaction with dietary salt intake.
Insights on the phenotypic heterogenity of 11?-hydroxylase deficiency: clinical and genetic studies in two novel families.
Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population.
Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension?
Juvenile hypertension, the role of genetically altered steroid metabolism.
Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study.
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
Letter by Keidar and Gamliel-Lazarovich regarding article, "Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial".
Lys(173)Arg and -344T/C variants of CYP11B2 in Japanese patients with low-renin hypertension.
Male Gender Identity and Reversible Hypokalemic Hypertension in a 46,XX Child with 11-Beta-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
Mechanisms of hypertension: the expanding role of aldosterone.
Mineralocorticoid Actions in the Brain and Hypertension.
Modulation of aldosterone levels by -344 C/T CYP11B2 polymorphism and spironolactone use in resistant hypertension.
Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension.
Monogenic low renin hypertension.
Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort.
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Mutations in human 11 beta-hydroxylase genes: 11 beta-hydroxylase deficiency in Jews of Morocco and corticosterone methyl-oxidase II deficiency in Jews of Iran.
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
Neonatal salt loss in the hypertensive form of congenital adrenal hyperplasia.
New drugs, procedures, and devices for hypertension.
Novel homozygous p.Y395X mutation in the CYP11B1 gene found in a Vietnamese patient with 11?-hydroxylase deficiency.
Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V.
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Pharmacophore Modeling and
Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas.
Polymorphism of CYP11B2 determines salt sensitivity in Japanese.
Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients.
Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension.
Predictors of successful outcome after adrenalectomy for primary aldosteronism.
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
Prolongation of growth by treatment of 11-hydroxylase deficiency with depot-leuprolide, growth hormone, and hydrocortisone.
RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension.
Reevaluation of the association of seven candidate genes with blood pressure and hypertension: a replication study and meta-analysis with a larger sample size.
Relationship between -344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension.
Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake.
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.
Renal function in relation to three candidate genes.
Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats.
Salt sensitivity of Japanese from the viewpoint of gene polymorphism.
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
Steroid responsive hypertension secondary to 11-beta hydroxylase deficiency--a case report.
Structural analysis and evaluation of the aldosterone synthase gene in hypertension.
Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Structure-function relationships of aldosterone synthase and 11 beta-hydroxylase enzymes: implications for human hypertension.
Study of aldosterone synthase inhibition as an add-on therapy in resistant hypertension.
Successful Pregnancy in a Patient with Severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene.
T allele of -344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension.
The -344C/T polymorphism in the CYP11B2 gene is associated with essential hypertension in the Chinese.
The central role of the brain aldosterone-"ouabain" pathway in salt-sensitive hypertension.
The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients.
The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
The Development of Hypertension and Hyperaldosteronism in a Rodent Model of Life-Long Obesity.
The Effects of Aldosterone Synthase Inhibition on Aldosterone and Cortisol in Patients With Hypertension: A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study.
The genetic basis of essential hypertension.
The genetic basis of hypertension.
The human genome contains only two CYP11B (P450c11) genes.
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
The inhibition of rat adrenal cytochrome P-45011 beta gene expression by androgens.
The relation between ACE D/I and CYP11B2 C-344T polymorphisms and parameters of arterial stiffness in the context of renal sodium handling.
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
Trilostane, FAD286, and the role of aldosterone in the central regulation of blood pressure: focus on "Role of central nervous system aldosterone synthase and mineralocorticoid receptors in salt-induced hypertension in Dahl salt-sensitive rats".
Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.
Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.
[11beta-hydroxylase deficiency: improvement of final height with growth hormone and gonadotropin-releasing hormone analog]
[Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension]
[Association of the complex of polymorphic markers of ACE genes, aldosteron synthetase and endothelial synthetase of nitric oxide with progression of chronic glomerulonephritis]
[Association of the T(-344)C polymorphism of aldosterone synthase gene CYP11B2 with essential hypertension in Xinjiang Kazakh isolated group.]
[Contribution of CYP11B2, REN and AGT genes in genetic predisposition to arterial hypertension associated with hyperaldosteronism]
[Correlativity between the polymorphisms of aldosterone synthase gene, Hind III restriction site on Y chromosome and essential hypertension]
[Deficiency of 11-hydroxylase in a case of congenital hyperplasia of the adrenal glands without arterial hypertension; clinical and biological study.]
[Female pseudo-hermaphroditism with complete virilism and arterial hypertension due to an 11-beta-hydroxylase defect diagnosed in an adult]
[Hypertension and gene polymorphisms]
[Hypertension-induced fibrosis: A balance story].
[Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population]
[Increase in plasma and urinary 17-hydroxycorticoids in a case of congenital hyperplasia of the adrenals without arterial hypertension. Identification of abnormal steroids related to a deficiency of 11beta-hydroxylase.]
[Mineralocorticoid syndromes and hypertension]
[New techniques and laboratory examinations in the detection and evaluation of hypertension]
[Promoter variants of aldosterone synthase gene (CYP11B2) and salt-sensitivity of blood pressure]
[Single nucleotide polymorphisms of the CYP11B2, GNB3 and NOS3 genes in various ethnic groups of arctic zone of yakutia suffering from arterial hypertension].
[Single nucleotide polymorphisms of three candidate genes in essential hypertension]
[Strategy for studying mineralocorticoids other than aldosterone in arterial hypertension of hormonal origin]
[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy]
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Hypertension, Malignant
Deoxycorticosterone, 11 beta-hydroxylase and the adrenal cortex.
Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Hypertension, Pregnancy-Induced
Aldosterone synthase gene polymorphism is not associated with gestational hypertension or preeclampsia.
Relationship of aldosterone synthase gene (C-344T) and mineralocorticoid receptor (S810L) polymorphisms with gestational hypertension.
Hypertension, Renovascular
A role for steroid hormones in the variability of blood pressure determination.
Hypertrophy, Left Ventricular
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension.
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response: result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial.
Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population.
Association of echocardiographic left ventricular structure and -344C/T aldosterone synthase gene variant: A meta-analysis.
Association of the -344T/C polymorphism in aldosterone synthase gene promoter with left ventricular structure in Chinese Han: A meta-analysis.
Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.
[Hereditary factors and left ventricular hypertrophy]
[Specifics of distribution of polymorphic markers of the renin-angiotensin-system genes, relation to ventricular hypertrophy in patients with essential hypertension of Uzbek nationality]
[The relationship of aldosterone synthase gene polymorphism with hypertension and left ventricular hypertrophy]
Hypoadrenocorticism, Familial
Aldosterone signaling defect in young infants: single-center report and review.
Effects of fetal androgen on childhood behavior.
Hypoaldosteronism
A case of primary selective hypoaldosteronism carrying three mutations in the aldosterone synthase (Cyp11b2) gene.
A missense mutation (GGC[435Gly]-->AGC[Ser]) in exon 8 of the CYP11B2 gene inherited in Japanese patients with congenital hypoaldosteronism.
Aldosterone synthase deficiency and related disorders.
Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency.
Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2.
Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature.
Congenital hyperreninemic hypoaldosteronism in Israel: sequence analysis of CYP11B2 gene.
Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene.
Defects in steroidogenic enzymes. Discrepancies between clinical steroid research and molecular biology results.
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations.
Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency.
Homozygous deletion of arginine-173 in the CYP11B2 gene in a girl with congenital hypoaldosteronism. Corticosterone methyloxidase deficiency type II.
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency.
Novel CYP11B2 mutation causing aldosterone synthase (P450c11AS) deficiency.
The Aldosterone/Renin Ratio as a Diagnostic Tool for the Diagnosis of Primary Hypoaldosteronism in Newborns and Infants.
Type 1 aldosterone synthase deficiency presenting in a middle-aged man.
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
Hypokalemia
A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report.
A novel CYP11B1 mutation in a Turkish patient with 11?-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
New aspects of mineralocorticoid hypertension.
Steroids and hypertension.
Hyponatremia
A compound heterozygote case of type II aldosterone synthase deficiency.
Abnormalities of aldosterone synthesis and action in children.
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene.
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Disorders of steroid 11 beta-hydroxylase isozymes.
Hypertension in a patient with aldosterone deficiency.
Hypospadias
Aldosterone synthase deficiency type II with hypospadias.
Comparative follow-up study of 130 children born after intracytoplasmic sperm injection and 130 children born after in-vitro fertilization.
Hypotension
Association of renin-angiotensin-aldosterone system genetic polymorphisms with maternal hypotension during spinal anaesthesia for caesarean delivery - a retrospective cohort study.
Hypotension, Orthostatic
The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene.
Infertility
Congenital adrenal hyperplasia.
Insulin Resistance
Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: A case-control study in a Han Chinese population.
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
The effects of the renin-angiotensin-aldosterone system gene polymorphisms on insulin resistance in hypertensive families.
Ischemic Attack, Transient
Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population.
Ischemic Stroke
Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs.
Association of CYP11B2 gene polymorphism with ischemic stroke in the north Chinese Han population.
Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke.
Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis.
Lack of an Association between CYP11B2 C-344T Gene Polymorphism and Ischemic Stroke: A Meta-Analysis of 7,710 Subjects.
The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis.
[A clinical and genetic analysis of risk factors for the development of acute and chronic cerebral ischemia].
[Association study of polymorphic markers of F12, PON1, PON2, NOS2, PDE4D, HIF1a, GPIba, CYP11B2 genes with ischemic stroke in Russian patients].
Kidney Failure, Chronic
Aldosterone Synthase Gene (CYP11B2) Polymorphism in Korean End-Stage Renal Disease Patients on Hemodialysis.
Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats.
Kidney Neoplasms
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Leiomyoma
Suicide inactivation of aromatase in human placenta and uterine leiomyoma by 5 alpha-dihydronorethindrone, a metabolite of norethindrone, and its effect on steroid-producing enzymes.
Leukemia
Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.
Leydig Cell Tumor
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor.
Liddle Syndrome
Genetic determinants of human hypertension.
Liver Cirrhosis
[CYP11B2 expression in rat liver and the efficacy of antisterone on liver fibrosis]
Malnutrition
Maternal Undernutrition Programs Offspring Adrenal Expression of Steroidogenic Enzymes.
Melanoma
Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.
Metabolic Diseases
An inherited defect in aldosterone biosynthesis caused by a mutation in or near the gene for steroid 11-hydroxylase.
Optimization of the First Selective Steroid-11?-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases.
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
Metabolic Syndrome
-344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men.
Association of CYP11B2 polymorphisms with metabolic syndrome patients.
Associations of the -344 T>C and the 3097 G>A Polymorphisms of CYP11B2 Gene With Hypertension, Type 2 Diabetes, and Metabolic Syndrome in a French Population.
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11?-hydroxylase.
Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure-Activity and Structure-Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives.
Mitral Valve Insufficiency
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure.
Muscle Weakness
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Muscular Diseases
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Myocardial Infarction
Analysis of promoter region polymorphism in the aldosterone synthase gene (CYP11B2) as a risk factor for myocardial infarction.
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.
Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction.
Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
[Genetic factors in myocardial infarction--Results from a candidate gene and a genome-wide approach between beta blockers]
Myocarditis
Evidence of aldosterone synthesis in human myocardium in acute myocarditis.
nadph-hemoprotein reductase deficiency
Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol.
Nasal Polyps
The expression of 11?-hydroxysteroid dehydrogenase type 1 and 2 in nasal polyp-derived epithelial cells and its possible contribution to glucocorticoid activation in nasal polyp.
Neoplasms
11 beta-Hydroxylase in mitochondrial fractions of functioning and non-functioning adrenocortical tumors.
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
A cAMP-responsive element regulates expression of the mouse steroid 11 beta-hydroxylase gene.
A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
A Novel Somatic Deletion Mutation of ATP2B3 in Aldosterone-Producing Adenoma.
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
Abundance of DLK1, differential expression of CYP11B1, CYP21A2 and MC2R, and lack of INSL3 distinguish testicular adrenal rest tumours from Leydig cell tumours.
Activating mutations in CTNNB1 in aldosterone producing adenomas.
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.
Adrenocortical carcinoma manifesting pure primary aldosteronism: a case report and analysis of steroidogenic enzymes.
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.
Aldosterone-producing adrenal cortical cancer: a case report and analysis of steroidogenic enzymes in the tumor.
Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs.
Characterization of the hamster CYP11B2 gene regulatory regions.
Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases.
Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome.
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.
Cloning of cDNA and genomic DNA for human cytochrome P-45011 beta.
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Cortisol production by testicular tumors in a patient with congenital adrenal hyperplasia (21-hydroxylase deficiency).
Different expression of 11?-hydroxylase and aldosterone synthase between aldosterone-producing microadenomas and macroadenomas.
Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study.
Double adenomas with different pathological and hormonal features in the left adrenal gland of a patient with Cushing's syndrome.
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Evaluation of Cortisol Production in Aldosterone-Producing Adenoma.
Evidence of 11 beta-hydroxylase deficiency in childhood adrenocortical tumors. The plasma corticosterone/11-deoxycorticosterone ratio as a possible marker for malignancy.
Expression of steroidogenic enzymes and their transcription factors in cortisol-producing adrenocortical adenomas: immunohistochemical analysis and quantitative real-time polymerase chain reaction studies.
Extraadrenal expression of steroid 21-hydroxylase and 11 beta-hydroxylase by a benign testicular Leydig cell tumor.
Extraordinarily high aldosterone, 901.0 ng/dL, in a patient with primary aldosteronism: an insight into the underlying mechanism.
Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism.
Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.
Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.
GENETICS IN ENDOCRINOLOGY: Impact of race and sex on genetic causes of aldosterone-producing adenomas.
H-score of 11?-hydroxylase and aldosterone synthase in the histopathological diagnosis of adrenocortical tumors.
Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations.
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Histopathological Diagnosis of Primary Aldosteronism Using CYP11B2 Immunohistochemistry.
Imaging of adrenal masses with emphasis on adrenocortical tumors.
Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas.
Impairment of 11 beta-hydroxylase but not 21-hydroxylase in adrenal 'incidentalomas'.
In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
Increased expression of CYP17 and CYP11B1 in subclinical Cushing's syndrome due to adrenal adenomas.
Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumours.
Integrated Analysis of Genome-wide Methylation and Gene Expression Shows Epigenetic Regulation of CYP11B2 in Aldosteronomas.
Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study.
Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats.
Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells.
MiR-193a-3p functions as a tumour suppressor in human aldosterone-producing adrenocortical adenoma by down-regulating CYP11B2.
Molecular Heterogeneity in Aldosterone-Producing Adenomas.
New aspects of mineralocorticoid hypertension.
Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice.
Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas.
Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders.
Origin of an ovarian steroid cell tumor causing isosexual pseudoprecocious puberty demonstrated by the expression of adrenal steroidogenic enzymes and adrenocorticotropin receptor.
PET imaging of adrenal cortical tumors with the 11beta-hydroxylase tracer 11C-metomidate.
Polymorphic differences from normal in the aldosterone synthase gene (CYP11B2) in patients with primary hyperaldosteronism and adrenal tumour (Conn's syndrome).
Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population.
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.
Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin.
Significance of steroidogenic enzymes in the pathogenesis of adrenal tumour.
Stable expression of rat cytochrome P450 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) in MA-10 cells.
Steroid contents and cortical steroidogenic enzymes in non-hyperfunctioning adrenal adenoma.
Steroid profile in urine: a useful tool in the diagnosis and follow up of adrenocortical carcinoma.
Steroidogenesis in isolated cells and mitochondria of rat Snell adrenocortical carcinoma 494.
Steroids and hypertension.
SY 03-3 OVERVIEW OF SOMATIC MUTATIONS AND EPIGENETIC REGULATION OF ALDOSTERONE PRODUCING ADENOMA (APA).
Targeted RNAseq of Formalin-Fixed Paraffin-Embedded Tissue to Differentiate Among Benign and Malignant Adrenal Cortical Tumors.
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Testicular adrenal rest tumor in a patient with 11beta-hydroxylase deficient congenital adrenal hyperplasia.
Testicular tumors in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency show functional features of adrenocortical tissue.
The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.
The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant "neoplastic" steroidogenesis in adrenals.
The impact of gene polymorphisms in angiotensin receptor 1 and aldosterone synthase in peritoneal dialysis patients.
The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.
The steroid metabolite 16(?)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1.
Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression.
Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma.
Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.
Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma.
Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
Wnt/?-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice.
[Endocrine and neurogenic hypertension in childhood]
[Medical treatment for Cushing's syndrome]
[Primary hyperaldosteronism and adenoma of the adrenal cortex. Suppression of aldosterone with dexamethasone]
[Treatment of male adrenogenital syndrome (report of 17 cases)]
Nephrocalcinosis
Renal Cysts and Nephrocalcinosis in 11 Beta-hydroxylase Deficiency.
Renal Cysts and Nephrocalcinosis in a Patient Deficient in 11 beta-Hydroxylase Enzyme.
Nephrotic Syndrome
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Neuroblastoma
[Endocrine and neurogenic hypertension in childhood]
Obesity
Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis.
Blood pressure response to angiotensin II is enhanced in obese Zucker rats and is attributed to an aldosterone-dependent mechanism.
Impact of Adrenal Steroids on Regulation of Adipose Tissue.
Leptin Induces Hypertension and Endothelial Dysfunction via Aldosterone-Dependent Mechanisms in Obese Female Mice.
Ovarian Diseases
Polycystic ovarian disease and congenital and late-onset adrenal hyperplasia.
Peritoneal Fibrosis
The impact of gene polymorphisms in angiotensin receptor 1 and aldosterone synthase in peritoneal dialysis patients.
Pheochromocytoma
Endocrine causes of hypertension.
Steroid enzyme activities in extraadrenal pheochromocytomas.
[Endocrine and neurogenic hypertension in childhood]
Pituitary ACTH Hypersecretion
Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design.
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase.
Investigating mineralocorticoid hypertension.
Ketoconazole and plasma and urine steroid levels in Cushing's disease.
Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease.
Osilodrostat: A Novel Steroidogenesis Inhibitor to Treat Cushing's Disease.
Partial 11 beta-hydroxylase activity suppression after dexamethasone in patients with major depression.
Preclinical Cushing's disease characterized by massive adrenal hyperplasia and hormonal changes after three years of metyrapone therapy.
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.
Use of ketoconazole in the treatment of Cushing's syndrome.
Polycystic Kidney Diseases
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Polycystic Ovary Syndrome
11 beta-Hydroxylase with affinity to C-21-Deoxysteroids from ovaries of patients with polycystic ovary syndrome.
Evidence for adrenal and/or ovarian dysfunction as a possible etiology of idiopathic hirsutism.
Radioimmunoassay of three deoxycorticoids in human plasma following HPLC separation.
The frequency of late-onset 21-hydroxylase and 11 beta-hydroxylase deficiency in women with polycystic ovary syndrome.
Post-Exercise Hypotension
Deep-targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans.
Pre-Eclampsia
Aldosterone synthase gene polymorphism is not associated with gestational hypertension or preeclampsia.
Allele, Genotype and Haplotype Structures of Functional Polymorphic Variants in Endothelial Nitric Oxide Synthase (eNOS), Angiotensinogen (ACE) and Aldosterone Synthase (CYP11B2) Genes in Healthy Pregnant Women of Indian Ethnicity.
Analysis of the gene polymorphism of aldosterone synthase (CYP11B2) and atrial natriuretic peptide (ANP) in women with preeclampsia.
Association of CYP11B2 gene polymorphism with preeclampsia in north east of Iran (Khorasan province).
Correlation between CYP11B2 polymorphism and the risk of preeclampsia.
Evidence for compromised aldosterone synthase enzyme activity in preeclampsia.
High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women.
MiR-4421 regulates the progression of preeclampsia by regulating CYP11B2.
OS058. Aldosterone deficiency adversely affects pregnancy outcome in mice.
Relationship of aldosterone synthase gene (C-344T) and mineralocorticoid receptor (S810L) polymorphisms with gestational hypertension.
Renin-angiotensin system gene variants and risk of early- and late-onset preeclampsia: A single center case-control study.
Prostatic Neoplasms
Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk.
Proteinuria
[The role of polymorphic markers of vasoactive hormones genes in clinical characteristics of chronic glomerulonephritis]
Pseudohypoaldosteronism
Epidemiologic study of adrenal gland disorders in Japan.
Hook Effect: A Pitfall Leading to Misdiagnosis of Hypoaldosteronism in an Infant with Pseudohypoaldosteronism.
Pseudotumor Cerebri
Pseudotumor cerebri in a boy with 11-beta-hydroxylase deficiency--a possible relation to rapid steroid withdrawal.
Puberty, Precocious
Benign testicular tumors in children with congenital adrenal hyperplasia.
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Combination growth hormone and gonadotropin releasing hormone analog therapy in 11beta-hydroxylase deficiency.
Genetic aspects of congenital adrenal hyperplasia.
Growth Hormone With Aromatase Inhibitor May Improve Height in CYP11B1 Congenital Adrenal Hyperplasia.
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Precocious pseudopuberty due to a rare form of congenital adrenal hyperplasia. Biochemical investigation and pitfalls in interpretation of hormone assays.
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
Pulmonary Edema
Association of polymorphisms in angiotensin and aldosterone synthase genes of the renin-angiotensin-aldosterone system with high-altitude pulmonary edema.
Pulmonary Valve Stenosis
Adrenogenital syndrome due to 11-beta-hydroxylase deficiency with skeletal abnormalities and pulmonary stenosis.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Renal Insufficiency
Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.
Renal Insufficiency, Chronic
Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
Aldosterone synthase gene is not a major susceptibility gene for progression of chronic kidney disease in patients with autosomal dominant polycystic kidney disease.
Aldosterone synthase inhibitors: targeting chronic kidney disease and diabetic nephropathy.
Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms.
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Modulation of aldosterone levels by aldosterone synthase promoter polymorphism and association with eGFR decline in patients with chronic kidney disease.
Respiratory Distress Syndrome
[A case of acute respiratory distress syndrome caused by cryptococcus and cytomegalovirus co-infection after Cushing's syndrome treatment].
Rhabdomyolysis
A novel CYP11B1 mutation in a Turkish patient with 11?-hydroxylase deficiency: An association with the severe hypokalemia leading to rhabdomyolysis.
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Seizures
11?-Hydoxylase Inhibitors Protect Against Seizures in Mice by Increasing Endogenous Neurosteroid Synthesis.
Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures.
Sepsis
RETRACTED: Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population.
RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression.
RETRACTED: Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy.
RETRACTED: Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population.
RETRACTED: Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy.
Retraction notice.
Starvation
Acute starvation affects rat adrenal steroidogenesis.
steroid 11beta-monooxygenase deficiency
"Masked" 21-hydroxylase deficiency of the adrenal presenting with gynecomastia and bilateral testicular masses.
11 Beta-hydroxylase deficiency congenital adrenal hyperplasia: update of prenatal diagnosis.
11 beta-hydroxylase deficiency in hyperandrogenism.
11 Beta-hydroxylase deficiency.
11 beta-hydroxylase deficiency: management of a difficult case by laparoscopic bilateral adrenalectomy.
11-deoxycortisol in amniotic fluid: prenatal diagnosis of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
11-Hydroxylase deficiency as a cause of pre-pubertal gynecomastia.
11Beta-Hydroxylase Deficiency and Other Syndromes of Mineralocorticoid Excess as a Rare Cause of Endocrine Hypertension.
11beta-hydroxylase deficiency masked by alternative medicines.
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
21-hydroxylase deficiency transiently mimicking combined 21- and 11beta-hydroxylase deficiency.
3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion.
9alpha-Fluorohydrocortisone therapy in aldosterone synthase deficiency.
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
A 5-year-old boy with cryptorchidism and pubic hair: investigation and management of apparent male disorders of sex development in mid-childhood.
A Case of 11beta-Hydroxylase Deficiency Detected in a Newborn Screening Program by Second-Tier LC-MS/MS.
A case of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency presenting as hemorrhagic stroke.
A compound heterozygote case of type II aldosterone synthase deficiency.
A homozygous L299P mutation in the CYP11B1 gene leads to complete virilization in 46,XX individuals with 11-beta-hydroxylase deficiency.
A mutation in CYP11B1 (Arg-448----His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin.
A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency.
A novel CYP11B2 gene mutation in an Asian family with aldosterone synthase deficiency.
A novel missense mutation, GGC(Arg454) --> TGC(Cys), of CYP11B1 gene identified in a Chinese family with steroid 11beta-hydroxylase deficiency.
A novel nonsense mutation in the Cyp11B1 gene from a subject with the steroid 11beta-hydroxylase form of congenital adrenal hyperplasia.
A particular phenotype in a girl with aldosterone synthase deficiency.
A patient with refractory testicular adrenal rest tumour in the setting of cyp11b1 deficiency congenital adrenal hyperplasia.
A pilot study for neonatal screening of congenital adrenal hyperplasia due to 21-hydroxylase and 11-beta-hydroxylase deficiency in Campania region.
A prevalent and three novel mutations in CYP11B1 gene identified in Chinese patients with 11-beta hydroxylase deficiency.
A prospective study of the prevalence of nonclassical congenital adrenal hyperplasia among women presenting with hyperandrogenic symptoms and signs.
Abnormalities of aldosterone synthesis and action in children.
Absence of nonclassical congenital adrenal hyperplasia in patients with precocious adrenarche.
Absence of steroid biosynthetic defects in heterozygote individuals for classic 11 beta-hydroxylase deficiency due to a R448H mutation in the CYP11B1 gene.
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
Acute adrenal crisis complicating hypertensive congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
Adrenal cortex, tumor, and peripheral production of deoxycorticosterone.
Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche.
ADRENOCORTICAL 11-BETA-HYDROXYLASE DEFICIENCY AND VIRILISM FIRST MANIFEST IN THE ADULT WOMEN.
Adrenogenital syndrome due to 11-beta-hydroxylase deficiency with skeletal abnormalities and pulmonary stenosis.
Aldosterone secretion a molecular perspective.
Aldosterone signaling defect in young infants: single-center report and review.
Aldosterone synthase (CYP11B2) deficiency among Palestinian infants: Three novel variants and genetic heterogeneity.
Aldosterone synthase deficiency and related disorders.
Aldosterone synthase deficiency caused by a homozygous L451F mutation in the CYP11B2 gene.
Aldosterone synthase deficiency type I with no documented homozygous mutations in the CYP11B2 gene.
Aldosterone synthase deficiency type I: hormonal and genetic analyses of two cases.
Aldosterone synthase deficiency type II with hypospadias.
Aldosterone synthase deficiency type II: an unusual presentation of the first Greek case reported with confirmed genetic analysis.
Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency.
An alternate pathway to androstenedione synthesis by human adrenals: evidence of a balance in 11 beta-hydroxylase and 17,20-lyase activities leading to androstenedione.
An inherited defect in aldosterone biosynthesis caused by a mutation in or near the gene for steroid 11-hydroxylase.
Anaesthesia for a girl with severe hypertension due to 11 beta-hydroxylase deficiency.
Analysis of novel heterozygous mutations in the CYP11B2 gene causing congenital aldosterone synthase deficiency and literature review.
Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency.
Androgen metabolism in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Apparent double defect in C11 beta and C21-steroid hydroxylation in congenital adrenal hyperplasia.
Ashwagandha root in the treatment of non-classical adrenal hyperplasia.
Benign testicular tumors in children with congenital adrenal hyperplasia.
Bilateral adrenalectomy for severe hypertension in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency: Long term follow-up.
Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1.
Bilateral ovarian steroid cell tumor in congenital adrenal hyperplasia due to classic 11beta-hydroxylase deficiency.
Bilateral testicular adrenal rests in a patient with 11-hydroxylase deficient congenital adrenal hyperplasia.
Bone turnover and bone mineral density in patients with congenital adrenal hyperplasia.
Catch-up growth and discontinuation of fludrocortisone treatment in aldosterone synthase deficiency.
Characterization of zona glomerulosa function in patients with classic and non-classic forms of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Chromatographic system for the simultaneous measurement of plasma 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone by radioimmunoassay: reference data for neonates and infants and its application in aldosterone-synthase deficiency.
Classic steroid 11 beta-hydroxylase deficiency caused by a C-->G transversion in exon 7 of CYP11B1.
Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency. A study of 25 patients.
Clinical perspectives in congenital adrenal hyperplasia due to 11?-hydroxylase deficiency.
Clinical variability of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11).
Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome.
Combination growth hormone and gonadotropin releasing hormone analog therapy in 11beta-hydroxylase deficiency.
Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia.
Combined 21-hydroxylase and 11beta-hydroxylase deficiency: patient report and molecular basis.
Congenital adrenal hyperplasia - how to improve the transition from adolescence to adult life.
Congenital adrenal hyperplasia 11beta-hydroxylase deficiency: two cases managed with bilateral adrenalectomy.
Congenital adrenal hyperplasia and P450 oxidoreductase deficiency.
Congenital adrenal hyperplasia caused by 11 beta-hydroxylase deficiency with onset of symptoms after one spontaneous pregnancy.
Congenital adrenal hyperplasia causing hypertension: an illustrative review.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency in Saudi Arabia: clinical and biochemical characteristics.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency: final diagnosis in adult age in three patients.
Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency in a Tunisian family.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency with skeletal abnormalities.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: description of a new mutation, R384X.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene.
Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency.
Congenital adrenal hyperplasia in pregnancy.
Congenital adrenal hyperplasia in Sweden 1969-1986. Prevalence, symptoms and age at diagnosis.
Congenital adrenal hyperplasia in Turkey: a review of 273 patients.
Congenital adrenal hyperplasia masquerading as periodic paralysis in an adolescent girl.
Congenital adrenal hyperplasia secondary to 11beta-hydroxylase deficiency in a domestic cat.
Congenital adrenal hyperplasia with 11 beta-hydroxylase deficiency.
Congenital Adrenal Hyperplasia with 11-Beta Hydroxylase Deficiency with Testicular Adrenal Rest Tumour.
Congenital adrenal hyperplasia with 11-hydroxylase deficiency. A case report and contribution to diagnosis.
Congenital adrenal hyperplasia.
Congenital adrenal hyperplasia: 11beta-hydroxylase deficiency.
Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol.
Congenital hyperreninemic hypoaldosteronism due to aldosterone synthase deficiency type I in a Portuguese patient - Case report and review of literature.
Congenital hyperreninemic hypoaldosteronism in Israel: sequence analysis of CYP11B2 gene.
Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene.
Congenital primary adrenal insufficiency and selective aldosterone defects presenting as salt-wasting in infancy: a single center 10-year experience.
Correction: Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Corticosterone Methyl Oxidase Deficiency Type 1 with Normokalemia in an Infant.
Cortisol production rate in children by gas chromatography/mass spectrometry using [1,2,3,4-13C]cortisol.
Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family.
CYP11B1 mutations causing congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Defects in steroidogenic enzymes. Discrepancies between clinical steroid research and molecular biology results.
Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.
Deoxycorticosterone and 17-ketosteroids. Elevated levels in adult hypertensive patients.
Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues.
Determination of 11-deoxycortisol (Reichstein's compound S) in human plasma by clinical isotope dilution mass spectrometry using benchtop gas chromatography-mass selective detection.
Diabetes mellitus associated with late onset congenital adrenal hyperplasia: coincidence or causality?
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Diagnosis of congenital adrenal hyperplasia with 11-hydroxylase deficiency by determination of tetrahydro-11-desoxycortisol in urine.
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
Difficulties in the diagnosis of congenital adrenal hyperplasia in early infancy: the 11 beta-hydroxylase defect.
Disorders of steroid 11 beta-hydroxylase isozymes.
Disorders of steroid 17 alpha-hydroxylase deficiency.
Disorders of the adrenal cortex: their effects on electrolyte metabolism.
Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia.
Does primary salt wasting occur in 11-beta-hydroxylase deficiency?
Donor splice mutation in the 11beta-hydroxylase (CypllB1) gene resulting in sex reversal: a case report and review of the literature.
Early diagnosis of 11 beta-hydroxylase deficiency in two siblings confirmed by analysis of a novel steroid metabolite in newborn urine.
Effects of fetal androgen on childhood behavior.
Endocrine causes of hypertension.
Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia.
Evidence for a new biologic pathway of androstenedione synthesis from 11-deoxycortisol.
Evidence for endocrinological abnormalities in heterozygotes for adrenal 11 beta-hydroxylase deficiency of a family with the R448H mutation in the CYP11B1 gene.
Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome.
Evidence of 11 beta-hydroxylase deficiency in a patient with cortical adrenal adenoma.
Evidence of 11 beta-hydroxylase deficiency in childhood adrenocortical tumors. The plasma corticosterone/11-deoxycorticosterone ratio as a possible marker for malignancy.
Familial pericentric inversion chromosome 3 and R448C mutation of CYP11B1 gene in Turkish kindred with 11beta-hydroxylase deficiency.
Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations.
Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses.
Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Gender identity in congenital adrenal hyperplasia secondary to 11-hydroxylase deficiency.
Gender Identity in Patients with Congenital Adrenal Hyperplasia.
Genetic aspects of congenital adrenal hyperplasia.
Genetic diseases of steroid metabolism.
Glucocorticoid receptors in patients with congenital adrenal hyperplasia.
Growth and pubertal development in patients with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Gynaecomastia in two prepubertal boys with congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Hereditary defect in biosynthesis of aldosterone: aldosterone synthase deficiency 1964-1997.
High frequency of congenital adrenal hyperplasia (classic 11 beta-hydroxylase deficiency) among Jews from Morocco.
HLA and congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
HLA and hormonal data for identification of heterozygotes in 11 beta- and 17 alpha-hydroxylase deficiency syndromes.
Homozygosity for a mutation in the CYP11B2 gene in an infant with congenital corticosterone methyl oxidase deficiency type II.
Hook Effect: A Pitfall Leading to Misdiagnosis of Hypoaldosteronism in an Infant with Pseudohypoaldosteronism.
Hormonal hypertension in children: 11beta-hydroxylase deficiency and apparent mineralocorticoid excess.
Hormonal studies in obligate heterozygotes and siblings of patients with 11 beta-hydroxylase deficiency congenital adrenal hyperplasia.
Hyperplasia of adrenal rest tissue causing a retroperitoneal mass in a child with 11 beta-hydroxylase deficiency.
Hypertension in a neonate with 11 beta-hydroxylase deficiency.
Hypertension in a patient with aldosterone deficiency.
Hypertensive congenital adrenal enzymatic defects detected by high-performance liquid chromatography of corticosteroids.
Hypokalemic rhabdomyolysis in a child with 11-hydroxylase deficiency.
Impairment of 11 beta-hydroxylase but not 21-hydroxylase in adrenal 'incidentalomas'.
Inborn errors of adrenal steroidogenesis.
Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene.
Kinetics and metabolism of 11-deoxycortisol in a patient with congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Late-onset congenital adrenal hyperplasia in women with hirsutism.
Male Gender Identity and Reversible Hypokalemic Hypertension in a 46,XX Child with 11-Beta-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
Malignant hypertension in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
MECHANISMS IN ENDOCRINOLOGY: Rare defects in adrenal steroidogenesis.
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency.
Missense mutation in CYP11B1 (CGA[Arg-384]-->GGA[Gly]) causes steroid 11 beta-hydroxylase deficiency.
Molecular Analysis of the CYP11B2 Gene in 62 Patients with Hypoaldosteronism Due to Aldosterone Synthase Deficiency.
Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.
Molecular genetics of congenital adrenal hyperplasia.
Molecular genetics of disorders of sex development in a highly consanguineous population.
Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients.
Mutations in CYP11B1 and congenital adrenal hyperplasia in Moroccan Jews.
Mutations in CYP11B1 gene: phenotype-genotype correlations.
Mutations in human 11 beta-hydroxylase genes: 11 beta-hydroxylase deficiency in Jews of Morocco and corticosterone methyl-oxidase II deficiency in Jews of Iran.
Mutations in the CYP11B1 gene causing congenital adrenal hyperplasia and hypertension cluster in exons 6, 7, and 8.
Neonatal salt loss in the hypertensive form of congenital adrenal hyperplasia.
Neonatal salt-wasting and 11 beta-hydroxylase deficiency in a child carrying a homozygous deletion hybrid CYP11B2 (aldosterone synthase)-CYP11B1 (11 beta-hydroxylase).
New aspects of mineralocorticoid hypertension.
New molecular genetic defects causing 11beta-hydroxylase deficiency (CAH).
New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia.
No linkage between HLA and congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency.
Nonclassic 11 beta-hydroxylase deficiency: report of two patients and review.
Novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Novel CYP11B2 mutation causing aldosterone synthase (P450c11AS) deficiency.
Novel missense mutations, GCC [Ala306]- > GTC [Val] and ACG [Thr318]- > CCG [Pro], in the CYP11B1 gene cause steroid 11beta-hydroxylase deficiency in the Chinese.
Novel mutations in CYP11B1 gene leading to 11 beta-hydroxylase deficiency in Brazilian patients.
Novel mutations in the CYP11B2 gene causing aldosterone synthase deficiency.
Only two mutations detected in 15 Tunisian patients with 11beta-hydroxylase deficiency: the p.Q356X and the novel p.G379V.
Over 50 Years of Progress in the Treatment of the Hypertensive Form of Congenital Adrenal Hyperplasia due to Steroid 11-Beta-Hydroxylase Deficiency. Commentary on Simm PJ and Zacharin MR: Successful Pregnancy in a Patient with severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene (Horm Res 2007;68:294-297).
Parallelism of 11 beta- and 18-hydroxylation demonstrated by urinary free hormones in man.
Partial deficiency of adrenal 11-hydroxylase. A possible cause of primary hypertension.
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Precocious pseudopuberty due to a rare form of congenital adrenal hyperplasia. Biochemical investigation and pitfalls in interpretation of hormone assays.
Prenatal diagnosis and treatment of 11beta-hydroxylase deficiency congenital adrenal hyperplasia resulting in normal female genitalia.
Prenatal diagnosis of 11beta-hydroxylase deficiency congenital adrenal hyperplasia.
Prenatal treatment of congenital adrenal hyperplasia. The United States experience.
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Prevalence of late-onset 11 beta-hydroxylase deficiency in hirsute patients.
Primary adrenal insufficiency with hypertension. A case report on partial primary adrenal insufficiency and partial 11-beta-hydroxylase deficiency.
Progress in molecular-genetic studies on congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Prolongation of growth by treatment of 11-hydroxylase deficiency with depot-leuprolide, growth hormone, and hydrocortisone.
Prostatic ejaculate in assigned males with 46,XX congenital adrenal hyperplasia.
Pseudotumor cerebri in a boy with 11-beta-hydroxylase deficiency--a possible relation to rapid steroid withdrawal.
Quantitation of 17-OH-progesterone (OHPG) for diagnosis of congenital adrenal hyperplasia (CAH).
Regulation of the mineralocorticoid hormones in adrenocortical disorders with adrenocorticotropin excess.
Renal Cysts and Nephrocalcinosis in 11 Beta-hydroxylase Deficiency.
Requirement of mineralocorticoid in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Restriction fragment length polymorphisms of the CYP11B1 gene in the Japanese population.
Reversed-phase high-performance liquid chromatography separation of adrenal steroids prior to radioimmunoassay: application in congenital adrenal hyperplasia.
Reversible cardiomyopathy caused by an uncommon form of congenital adrenal hyperplasia.
Roux-en-Y gastric bypass in the treatment of non-classic congenital adrenal hyperplasia due to 11-hydroxylase deficiency.
Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
Salt loss in congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency.
Salt loss in hypertensive form of congenital adrenal hyperplasia (11-beta-hydroxylase deficiency).
Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia.
Serum 11 beta-hydroxyandrostenedione as an indicator of the source of excess androgen production in women with polycystic ovaries.
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency.
Serum cortisol and 11-desoxycortisol levels in hirsute premenopausal women.
Sex reassignment in a girl with 11 beta-hydroxylase deficiency.
Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene.
Sonographic findings in infants with congenital adrenal hyperplasia.
Steroid 11 beta-hydroxylase deficiency and related disorders.
Steroid 11 beta-hydroxylase deficiency caused by a five base pair duplication in the CYP11B1 gene.
Steroid 11-beta hydroxylase deficiency caused by compound heterozygosity for a novel mutation in intron 7 (IVS 7 DS+4A to G) in one CYP11B1 allele and R448H in exon 8 in the other.
Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
Steroid 11beta- hydroxylase deficiency congenital adrenal hyperplasia.
Successful Pregnancy in a Patient with Severe 11-Beta-Hydroxylase Deficiency and Novel Mutations in CYP11B1 Gene.
Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia.
Testicular adrenal rest tumor in 11-Beta-hydroxylase deficiency driven congenital adrenal hyperplasia.
Testicular adrenal rest tumors in congenital adrenal hyperplasia-cross-sectional study of 51 Croatian male patients.
Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function.
Testicular adrenal-like tissue (TALT) in congenital adrenal hyperplasia: detection by ultrasonography.
Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
Testicular enlargement in patients with 11-hydroxylase deficiency.
The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene.
The frequency of late-onset 21-hydroxylase and 11 beta-hydroxylase deficiency in women with polycystic ovary syndrome.
The natural history of salt-wasting disorders of adrenal and renal origin.
The prevalence of late onset congenital adrenal hyperplasia in hirsute women from Central Anatolia.
The prevalence of non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency among hirsute women in a Turkish population.
The renin-angiotensin-aldosterone system in primary and secondary hypertension.
The steroid metabolite 16(?)-OH-androstenedione generated by CYP21A2 serves as a substrate for CYP19A1.
The steroid response to controlled adrenal stimulation in congenital adrenal hyperplasia.
The value of low dose (1 microg) ACTH stimulation test in the investigation of non-classic adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Three novel CYP11B1 mutations in congenital adrenal hyperplasia due to steroid 11Beta-hydroxylase deficiency in a moroccan population.
Treatment of Nonclassic 11-Hydroxylase Deficiency with Ashwagandha Root.
Triple-x syndrome accompanied by congenital adrenal hyperplasia: case report.
Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Two novel mutations of the CYP11B2 gene in a Japanese patient with aldosterone deficiency type 1.
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
Type 1 aldosterone synthase deficiency presenting in a middle-aged man.
Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia.
Update on the prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency.
Virilizing adrenal tumour mimicking congenital adrenal hyperplasia with P450c11 (11 beta-hydroxylase) deficiency.
X-linked adrenal hypoplasia congenita caused by a novel intronic mutation of the DAX-1 gene.
[11 beta hydroxylase deficiency: a clinical study of seven cases]
[11 beta-hydroxylase deficiency]
[11-beta-hydroxylase deficiency and glucocorticoid-sensitive hyperaldosteronism]
[11beta-hydroxylase deficiency: improvement of final height with growth hormone and gonadotropin-releasing hormone analog]
[11beta-hydroxylase deficiency]
[11Beta-hydroxylase deficiency]
[Acne infantum as presenting symptom of congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
[Adrenal enzymatic block with late-onset caused by 11-hydroxylase deficiency. Apropos of 29 cases]
[Aldosterone synthase deficiency]
[Bilateral testicular hypertrophy and congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
[Clinical and genetic analysis of an infant with aldosterone synthase deficiency].
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
[Congenital adrenal hyperplasia caused by 11beta-hydroxylase deficiency. A case report]
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency - different HLA genotypes in 2 brothers]
[Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency]
[Congenital adrenal hyperplasia. Presentation of a case and review of the literature]
[Congenital adrenal hyperplasia]
[Congenital virilizing adrenal hyperplasia due to 11 beta-hydroxylase deficiency. Study of eleven cases (author's transl)]
[Defects of adrenal steroidogenesis in patients with hirsutism]
[Diagnosis of the adrenogenital syndrome caused by 11beta-hydroxylase deficiency using gas chromatographic-mass spectrometric analysis of the urinary steroid profile]
[Endocrine and neurogenic hypertension in childhood]
[Familial congenital adrenal hyperplasia caused by 11 beta-hydroxylase. Failure of prevention of sexual ambiguity and prenatal diagnosis]
[Four cases of aldosterone synthase deficiency in childhood].
[Hirsutism and light forms of congenital adrenogenital syndrome with 21- and 11-beta hydroxylase defect]
[Late diagnosis hyperandrogenism due to adrenal enzyme deficiency (author's transl)]
[Molecular genetic verification of isolated mineralocorticoid deficiency due to aldosterone synthase deficiency].
[Partial 3-beta-hydroxysteroid dehydrogenase deficiencies]
[Primary hypoaldosteronism and moderate bilateral deafness in a child with a homozygous missense mutation (Thr318Met) in the CYP11B2 gene].
[PSEUDOHERMAPHRODITISM WITH ADRENOGENITAL SYNDROME AND PARTIAL 11-BETA-HYDROXYLASE DEFICIENCY.]
[Rare forms of female pseudohermaphroditism: when to investigate?]
[Severe form of congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency in a 3-year old boy]
[Treatment of male adrenogenital syndrome (report of 17 cases)]
[Variations of production rate of cortisol, corticosterone, aldosterone and desoxycorticosterone in 4 cases of congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency]
steroid 17alpha-monooxygenase deficiency
Two rare forms of congenital adrenal hyperplasia, 11? hydroxylase deficiency and 17-hydroxylase/17,20-lyase deficiency, presenting with novel mutations.
steroid 21-monooxygenase deficiency
11 beta-hydroxylase deficiency: management of a difficult case by laparoscopic bilateral adrenalectomy.
15 beta-hydroxylated steroids may be diagnostically misleading in confirming congenital adrenal hyperplasia suspected by a newborn screening programme.
21-Hydroxylase and 11beta-hydroxylase mutations in Romanian patients with classic congenital adrenal hyperplasia.
21-hydroxylase deficiency transiently mimicking combined 21- and 11beta-hydroxylase deficiency.
3 alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: a useful serum metabolic marker of integrated adrenal androgen secretion.
A detailed investigation of hirsutism in a Turkish population: idiopathic hyperandrogenemia as a perplexing issue.
A pilot study for neonatal screening of congenital adrenal hyperplasia due to 21-hydroxylase and 11-beta-hydroxylase deficiency in Campania region.
ACTH stimulation tests and plasma dehydroepiandrosterone sulfate levels in women with hirsutism.
Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche.
Adrenal steroidogenic function in a black and Hispanic population with precocious pubarche.
Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies.
Benign testicular tumors in children with congenital adrenal hyperplasia.
Bone turnover and bone mineral density in patients with congenital adrenal hyperplasia.
Combined 21- and 11 beta-hydroxylase deficiency in familial congenital adrenal hyperplasia.
Congenital adrenal hyperplasia due to 11 beta-hydroxylase deficiency: final diagnosis in adult age in three patients.
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency: functional consequences of four CYP11B1 mutations.
Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency.
Congenital adrenal hyperplasia family studies using the short ACTH test.
Congenital adrenal hyperplasia in pregnancy.
Congenital adrenal hyperplasia in Sweden 1969-1986. Prevalence, symptoms and age at diagnosis.
Congenital adrenal hyperplasia with 11 beta-hydroxylase deficiency.
Congenital adrenal hyperplasia.
Diagnosis of adrenal cortical dysfunction by liquid chromatography-tandem mass spectrometry.
Diagnosis of homozygosity and heterozygosity in congenital adrenal hyperplasia (CAH) and control of treatment.
Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia.
Effect of hydrocortisone dose schedule on adrenal steroid secretion in congenital adrenal hyperplasia.
Effects of fetal androgen on childhood behavior.
Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia.
Glucocorticoid receptors in patients with congenital adrenal hyperplasia.
Late-onset congenital adrenal hyperplasia in women with hirsutism.
Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas.
Molecular genetics of congenital adrenal hyperplasia.
Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.
Prenatal treatment of congenital adrenal hyperplasia. The United States experience.
Reversed-phase high-performance liquid chromatography separation of adrenal steroids prior to radioimmunoassay: application in congenital adrenal hyperplasia.
Salivary and plasma androstenedione and 17-hydroxyprogesterone levels in congenital adrenal hyperplasia.
Secondary biosynthetic defects in women with late-onset congenital adrenal hyperplasia.
Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency.
Testicular adrenal rest tumors in congenital adrenal hyperplasia-cross-sectional study of 51 Croatian male patients.
Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function.
Testicular adrenal-like tissue (TALT) in congenital adrenal hyperplasia: detection by ultrasonography.
Testicular adrenal-like tissue in a patient with 17 alpha-hydroxylase deficiency.
The steroid response to controlled adrenal stimulation in congenital adrenal hyperplasia.
[Congenital adrenal hyperplasia caused by 11-beta-hydroxylase deficiency]
[Results of genitoplasty for virilized genitalia of 41 females with congenital adrenal hyperplasia]
[Treatment of male adrenogenital syndrome (report of 17 cases)]
Stroke
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia.
Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs.
Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension.
Association of -344C/T polymorphism in the aldosterone synthase (CYP11B2) gene with cardiac and cerebrovascular events in Chinese patients with hypertension.
Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke.
Genetic polymorphism of CYP11B2 gene and stroke in the Han Chinese population and a meta-analysis.
The CYP11B2 -344C/T variant is associated with ischemic stroke risk: An updated meta-analysis.
Testicular Neoplasms
A 2-year-old boy with a testicular mass. Diagnosis: testicular tumor of adrenogenital syndrome due to 11-beta-hydroxylase deficiency.
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Tuberous Sclerosis
Prepubertal gynecomastia with lobules and acini: a case report and review of the literature.
Ventricular Dysfunction, Left
Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart.
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction.